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<!--
|
||
UID=44124
|
||
ConceptID=C0023462
|
||
-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Acute megakaryoblastic leukemia</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>44124</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0023462</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Acute megakaryocytic leukemia</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Acute megakaryoblastic leukemia, FAB M7 (277602003); Acute megakaryoblastic leukemia, morphology (52220008); Thrombocytic leukemia (188754005); Megakaryocytic leukemia (188754005); Acute megakaryoblastic leukemia (277602003); M7 - Acute megakaryoblastic leukemia (277602003); Acute megakaryoblastic leukemia (52220008); Megakaryocytic leukemia (52220008); Megakaryocytic myelosis (52220008); Malignant megakaryocytosis (52220008); Megakaryoblastic leukemia (52220008); FAB M7 (52220008)</td></tr>
|
||
<tr><td>Modes of inheritance:</td>
|
||
<td>
|
||
<div class="divPopper rprt" id="moi_988794"><div><strong>Not genetically inherited</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>988794</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms that cannot be identified in NLM's Unified Medical Language system (UMLS) Click for more information.">CN307044</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Source: Orphanet</div>
|
||
<div class="spaceAbove">clinical entity without genetic inheritance.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/988794">This record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_988794" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Not genetically inherited</a><span> (Orphanet)</span></div></td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0006733">HP:0006733</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0018872" target="_blank">MONDO:0018872</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=518">ORPHA518</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">A rare subtype of acute myeloid leukemia evolving from primitive megakaryoblasts. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
||
</div>
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||
|
||
<div class="portlet mgSection" id="ID_118">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0023462[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=44124">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=44124" ref="ncbi_uid=44124">V</a></span></span><span class="TLline">Acute megakaryoblastic leukemia</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/208860" ref="tree=MeSH" title="MedGen record for Hematopoietic and Lymphatic System Disorder">Hematopoietic and Lymphatic System Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/5483" ref="tree=MeSH" title="MedGen record for Hematologic disorder">Hematologic disorder</a></span><ul><li><span class="TLline"><a href="/medgen/138213" ref="tree=MeSH" title="MedGen record for Hematologic neoplasm">Hematologic neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/9725" ref="tree=MeSH" title="MedGen record for Leukemia">Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/43225" ref="tree=MeSH" title="MedGen record for Acute leukemia">Acute leukemia</a></span><ul><li><span class="matched_ds">Acute megakaryoblastic leukemia</span><ul><li><span class="TLline"><a href="/medgen/79016" ref="tree=MeSH" title="MedGen record for Acute megakaryoblastic leukemia in adult">Acute megakaryoblastic leukemia in adult</a></span></li><li><span class="TLline"><a href="/medgen/1863778" ref="tree=MeSH" title="MedGen record for Acute megakaryoblastic leukemia in down syndrome">Acute megakaryoblastic leukemia in down syndrome</a></span></li><li><span class="TLline"><a href="/medgen/1843134" ref="tree=MeSH" title="MedGen record for Acute megakaryoblastic leukemia without down syndrome">Acute megakaryoblastic leukemia without down syndrome</a></span></li><li><span class="TLline"><a href="/medgen/79023" ref="tree=MeSH" title="MedGen record for Childhood acute megakaryoblastic leukemia">Childhood acute megakaryoblastic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1718677" ref="tree=MeSH" title="MedGen record for Recurrent Acute Megakaryoblastic Leukemia">Recurrent Acute Megakaryoblastic Leukemia</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_4385"><div><strong>Down syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>4385</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0013080</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Down syndrome is a chromosomal condition that is associated with intellectual disability, a characteristic facial appearance, and weak muscle tone (hypotonia) in infancy. All affected individuals experience cognitive delays, but the intellectual disability is usually mild to moderate.\n\nPeople with Down syndrome often have a characteristic facial appearance that includes a flattened appearance to the face, outside corners of the eyes that point upward (upslanting palpebral fissures), small ears, a short neck, and a tongue that tends to stick out of the mouth. Affected individuals may have a variety of birth defects. Many people with Down syndrome have small hands and feet and a single crease across the palms of the hands. About half of all affected children are born with a heart defect. Digestive abnormalities, such as a blockage of the intestine, are less common.\n\nIndividuals with Down syndrome have an increased risk of developing several medical conditions. These include gastroesophageal reflux, which is a backflow of acidic stomach contents into the esophagus, and celiac disease, which is an intolerance of a wheat protein called gluten. About 15 percent of people with Down syndrome have an underactive thyroid gland (hypothyroidism). The thyroid gland is a butterfly-shaped organ in the lower neck that produces hormones. Individuals with Down syndrome also have an increased risk of hearing and vision problems. Additionally, a small percentage of children with Down syndrome develop cancer of blood-forming cells (leukemia).\n\nDelayed development and behavioral problems are often reported in children with Down syndrome. Affected individuals can have growth problems and their speech and language develop later and more slowly than in children without Down syndrome. Additionally, speech may be difficult to understand in individuals with Down syndrome. Behavioral issues can include attention problems, obsessive/compulsive behavior, and stubbornness or tantrums. A small percentage of people with Down syndrome are also diagnosed with developmental conditions called autism spectrum disorders, which affect communication and social interaction.\n\nPeople with Down syndrome often experience a gradual decline in thinking ability (cognition) as they age, usually starting around age 50. Down syndrome is also associated with an increased risk of developing Alzheimer's disease, a brain disorder that results in a gradual loss of memory, judgment, and ability to function. Approximately half of adults with Down syndrome develop Alzheimer's disease. Although Alzheimer's disease is usually a disorder that occurs in older adults, people with Down syndrome commonly develop this condition earlier, in their fifties or sixties.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/4385">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_4385" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Down syndrome</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38299674">A retrospective analysis of gene fusions and treatment outcomes in pediatric acute megakaryoblastic leukemia without Down syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Suzuki K,
|
||
Hama A,
|
||
Okuno Y,
|
||
Xu Y,
|
||
Narita A,
|
||
Yoshida N,
|
||
Muramatsu H,
|
||
Nishio N,
|
||
Kato K,
|
||
Kojima S,
|
||
Yoo KH,
|
||
Takahashi Y</span><br />
|
||
<span class="medgenPMjournal">Haematologica</span>
|
||
2024 Jun 1;109(6):1936-1940.
|
||
doi: 10.3324/haematol.2023.283760.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38299674" target="_blank">38299674</a><a href="/pmc/articles/PMC11141654" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30991862">Molecular features, prognosis, and novel treatment options for pediatric acute megakaryoblastic leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">De Marchi F,
|
||
Araki M,
|
||
Komatsu N</span><br />
|
||
<span class="medgenPMjournal">Expert Rev Hematol</span>
|
||
2019 May;12(5):285-293.
|
||
Epub 2019 Apr 27
|
||
doi: 10.1080/17474086.2019.1609351.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30991862" target="_blank">30991862</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15920489">Acute megakaryoblastic leukemia in children and adolescents, excluding Down's syndrome: improved outcome with intensified induction treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Reinhardt D,
|
||
Diekamp S,
|
||
Langebrake C,
|
||
Ritter J,
|
||
Stary J,
|
||
Dworzak M,
|
||
Schrauder A,
|
||
Zimmermann M,
|
||
Fleischhack G,
|
||
Ludwig WD,
|
||
Harbott J,
|
||
Creutzig U</span><br />
|
||
<span class="medgenPMjournal">Leukemia</span>
|
||
2005 Aug;19(8):1495-6.
|
||
doi: 10.1038/sj.leu.2403815.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15920489" target="_blank">15920489</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22acute%20megakaryoblastic%20leukemia%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (8)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38513239">Landscape of driver mutations and their clinical effects on Down syndrome-related myeloid neoplasms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sato T,
|
||
Yoshida K,
|
||
Toki T,
|
||
Kanezaki R,
|
||
Terui K,
|
||
Saiki R,
|
||
Ojima M,
|
||
Ochi Y,
|
||
Mizuno S,
|
||
Yoshihara M,
|
||
Uechi T,
|
||
Kenmochi N,
|
||
Tanaka S,
|
||
Matsubayashi J,
|
||
Kisai K,
|
||
Kudo K,
|
||
Yuzawa K,
|
||
Takahashi Y,
|
||
Tanaka T,
|
||
Yamamoto Y,
|
||
Kobayashi A,
|
||
Kamio T,
|
||
Sasaki S,
|
||
Shiraishi Y,
|
||
Chiba K,
|
||
Tanaka H,
|
||
Muramatsu H,
|
||
Hama A,
|
||
Hasegawa D,
|
||
Sato A,
|
||
Koh K,
|
||
Karakawa S,
|
||
Kobayashi M,
|
||
Hara J,
|
||
Taneyama Y,
|
||
Imai C,
|
||
Hasegawa D,
|
||
Fujita N,
|
||
Yoshitomi M,
|
||
Iwamoto S,
|
||
Yamato G,
|
||
Saida S,
|
||
Kiyokawa N,
|
||
Deguchi T,
|
||
Ito M,
|
||
Matsuo H,
|
||
Adachi S,
|
||
Hayashi Y,
|
||
Taga T,
|
||
Saito AM,
|
||
Horibe K,
|
||
Watanabe K,
|
||
Tomizawa D,
|
||
Miyano S,
|
||
Takahashi S,
|
||
Ogawa S,
|
||
Ito E</span><br />
|
||
<span class="medgenPMjournal">Blood</span>
|
||
2024 Jun 20;143(25):2627-2643.
|
||
doi: 10.1182/blood.2023022247.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38513239" target="_blank">38513239</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34204358">Cytogenetics of Pediatric Acute Myeloid Leukemia: A Review of the Current Knowledge.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Quessada J,
|
||
Cuccuini W,
|
||
Saultier P,
|
||
Loosveld M,
|
||
Harrison CJ,
|
||
Lafage-Pochitaloff M</span><br />
|
||
<span class="medgenPMjournal">Genes (Basel)</span>
|
||
2021 Jun 17;12(6)
|
||
doi: 10.3390/genes12060924.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34204358" target="_blank">34204358</a><a href="/pmc/articles/PMC8233729" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31092368">The changing scenario of non-Down syndrome acute megakaryoblastic leukemia in children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Masetti R,
|
||
Guidi V,
|
||
Ronchini L,
|
||
Bertuccio NS,
|
||
Locatelli F,
|
||
Pession A</span><br />
|
||
<span class="medgenPMjournal">Crit Rev Oncol Hematol</span>
|
||
2019 Jun;138:132-138.
|
||
Epub 2019 Apr 15
|
||
doi: 10.1016/j.critrevonc.2019.04.011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31092368" target="_blank">31092368</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19698926">Gene expression profiling in acute myeloid leukaemia (AML).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bacher U,
|
||
Kohlmann A,
|
||
Haferlach C,
|
||
Haferlach T</span><br />
|
||
<span class="medgenPMjournal">Best Pract Res Clin Haematol</span>
|
||
2009 Jun;22(2):169-80.
|
||
doi: 10.1016/j.beha.2009.04.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19698926" target="_blank">19698926</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7496359">Acute megakaryoblastic leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gassmann W,
|
||
Löffler H</span><br />
|
||
<span class="medgenPMjournal">Leuk Lymphoma</span>
|
||
1995;18 Suppl 1:69-73.
|
||
doi: 10.3109/10428199509075307.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7496359" target="_blank">7496359</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acute%20megakaryoblastic%20leukemia%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (172)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36508699">Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kuusanmäki H,
|
||
Dufva O,
|
||
Vähä-Koskela M,
|
||
Leppä AM,
|
||
Huuhtanen J,
|
||
Vänttinen I,
|
||
Nygren P,
|
||
Klievink J,
|
||
Bouhlal J,
|
||
Pölönen P,
|
||
Zhang Q,
|
||
Adnan-Awad S,
|
||
Mancebo-Pérez C,
|
||
Saad J,
|
||
Miettinen J,
|
||
Javarappa KK,
|
||
Aakko S,
|
||
Ruokoranta T,
|
||
Eldfors S,
|
||
Heinäniemi M,
|
||
Theilgaard-Mönch K,
|
||
Wartiovaara-Kautto U,
|
||
Keränen M,
|
||
Porkka K,
|
||
Konopleva M,
|
||
Wennerberg K,
|
||
Kontro M,
|
||
Heckman CA,
|
||
Mustjoki S</span><br />
|
||
<span class="medgenPMjournal">Blood</span>
|
||
2023 Mar 30;141(13):1610-1625.
|
||
doi: 10.1182/blood.2021011094.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36508699" target="_blank">36508699</a><a href="/pmc/articles/PMC10651789" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35103363">Therapy-related acute megakaryoblastic leukemia with severe myelofibrosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yoshino H,
|
||
Gemma Y,
|
||
Miyazawa N,
|
||
Bessho F,
|
||
Yan K</span><br />
|
||
<span class="medgenPMjournal">Pediatr Int</span>
|
||
2022 Jan;64(1):e14842.
|
||
doi: 10.1111/ped.14842.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35103363" target="_blank">35103363</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34304781">Infant Acute Leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wertheim G</span><br />
|
||
<span class="medgenPMjournal">Clin Lab Med</span>
|
||
2021 Sep;41(3):541-550.
|
||
doi: 10.1016/j.cll.2021.04.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34304781" target="_blank">34304781</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34204358">Cytogenetics of Pediatric Acute Myeloid Leukemia: A Review of the Current Knowledge.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Quessada J,
|
||
Cuccuini W,
|
||
Saultier P,
|
||
Loosveld M,
|
||
Harrison CJ,
|
||
Lafage-Pochitaloff M</span><br />
|
||
<span class="medgenPMjournal">Genes (Basel)</span>
|
||
2021 Jun 17;12(6)
|
||
doi: 10.3390/genes12060924.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34204358" target="_blank">34204358</a><a href="/pmc/articles/PMC8233729" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26228843">Acute megakaryocytic leukemia: What have we learned.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hahn AW,
|
||
Li B,
|
||
Prouet P,
|
||
Giri S,
|
||
Pathak R,
|
||
Martin MG</span><br />
|
||
<span class="medgenPMjournal">Blood Rev</span>
|
||
2016 Jan;30(1):49-53.
|
||
Epub 2015 Jul 18
|
||
doi: 10.1016/j.blre.2015.07.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26228843" target="_blank">26228843</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acute%20megakaryoblastic%20leukemia%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (312)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36508699">Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kuusanmäki H,
|
||
Dufva O,
|
||
Vähä-Koskela M,
|
||
Leppä AM,
|
||
Huuhtanen J,
|
||
Vänttinen I,
|
||
Nygren P,
|
||
Klievink J,
|
||
Bouhlal J,
|
||
Pölönen P,
|
||
Zhang Q,
|
||
Adnan-Awad S,
|
||
Mancebo-Pérez C,
|
||
Saad J,
|
||
Miettinen J,
|
||
Javarappa KK,
|
||
Aakko S,
|
||
Ruokoranta T,
|
||
Eldfors S,
|
||
Heinäniemi M,
|
||
Theilgaard-Mönch K,
|
||
Wartiovaara-Kautto U,
|
||
Keränen M,
|
||
Porkka K,
|
||
Konopleva M,
|
||
Wennerberg K,
|
||
Kontro M,
|
||
Heckman CA,
|
||
Mustjoki S</span><br />
|
||
<span class="medgenPMjournal">Blood</span>
|
||
2023 Mar 30;141(13):1610-1625.
|
||
doi: 10.1182/blood.2021011094.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36508699" target="_blank">36508699</a><a href="/pmc/articles/PMC10651789" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36252553">JAK: Not Just Another Kinase.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Agashe RP,
|
||
Lippman SM,
|
||
Kurzrock R</span><br />
|
||
<span class="medgenPMjournal">Mol Cancer Ther</span>
|
||
2022 Dec 2;21(12):1757-1764.
|
||
doi: 10.1158/1535-7163.MCT-22-0323.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36252553" target="_blank">36252553</a><a href="/pmc/articles/PMC10441554" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26228843">Acute megakaryocytic leukemia: What have we learned.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hahn AW,
|
||
Li B,
|
||
Prouet P,
|
||
Giri S,
|
||
Pathak R,
|
||
Martin MG</span><br />
|
||
<span class="medgenPMjournal">Blood Rev</span>
|
||
2016 Jan;30(1):49-53.
|
||
Epub 2015 Jul 18
|
||
doi: 10.1016/j.blre.2015.07.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26228843" target="_blank">26228843</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25571789">MiR-125b and miR-99a encoded on chromosome 21 co-regulate vincristine resistance in childhood acute megakaryoblastic leukemia.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Kandi R,
|
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|
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|
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|
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<div class="nl"><a target="_blank" href="/pubmed/3321447">Uncommon subtypes of acute nonlymphocytic leukemia: clinical features and management of FAB M5, M6 and M7.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Peterson BA,
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<span class="medgenPMjournal">Semin Oncol</span>
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1987 Dec;14(4):425-34.
|
||
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acute%20megakaryoblastic%20leukemia%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (138)</a></div><h3 class="subhead">Prognosis</h3>
|
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<div class="nl"><a target="_blank" href="/pubmed/36508699">Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia.</a></div>
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Vähä-Koskela M,
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Aakko S,
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Heinäniemi M,
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Theilgaard-Mönch K,
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Keränen M,
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Porkka K,
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Konopleva M,
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||
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<span class="bold">PMID: </span><a href="/pubmed/36508699" target="_blank">36508699</a><a href="/pmc/articles/PMC10651789" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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||
<div class="nl"><a target="_blank" href="/pubmed/34204358">Cytogenetics of Pediatric Acute Myeloid Leukemia: A Review of the Current Knowledge.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Quessada J,
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Saultier P,
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Harrison CJ,
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<span class="medgenPMjournal">Genes (Basel)</span>
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2021 Jun 17;12(6)
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doi: 10.3390/genes12060924.
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<span class="bold">PMID: </span><a href="/pubmed/34204358" target="_blank">34204358</a><a href="/pmc/articles/PMC8233729" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/31548219">Acute Megakaryocytic Leukemia.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">McNulty M,
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<span class="medgenPMjournal">Cold Spring Harb Perspect Med</span>
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2020 Feb 3;10(2)
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<div class="nl"><a target="_blank" href="/pubmed/26228843">Acute megakaryocytic leukemia: What have we learned.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Hahn AW,
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Li B,
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Prouet P,
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<span class="medgenPMjournal">Blood Rev</span>
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2016 Jan;30(1):49-53.
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Epub 2015 Jul 18
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<span class="bold">PMID: </span><a href="/pubmed/26228843" target="_blank">26228843</a></div>
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||
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||
<div class="nl"><a target="_blank" href="/pubmed/23350067">Transient myeloproliferative disorder.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Moiz B,
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Shafiq M</span><br />
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<span class="medgenPMjournal">Blood</span>
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2012 Dec 6;120(24):4672.
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doi: 10.1182/blood-2012-07-440917.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23350067" target="_blank">23350067</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acute%20megakaryoblastic%20leukemia%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (216)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36789545">Pathologic, cytogenetic, and molecular features of acute myeloid leukemia with megakaryocytic differentiation: A report from the Children's Oncology Group.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chisholm KM,
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||
Smith J,
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||
Heerema-McKenney AE,
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||
Choi JK,
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||
Ries RE,
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||
Hirsch BA,
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||
Raimondi SC,
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||
Wang YC,
|
||
Dang A,
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||
Alonzo TA,
|
||
Sung L,
|
||
Aplenc R,
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||
Gamis AS,
|
||
Meshinchi S,
|
||
Kahwash SB</span><br />
|
||
<span class="medgenPMjournal">Pediatr Blood Cancer</span>
|
||
2023 May;70(5):e30251.
|
||
Epub 2023 Feb 15
|
||
doi: 10.1002/pbc.30251.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36789545" target="_blank">36789545</a><a href="/pmc/articles/PMC10038909" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36252553">JAK: Not Just Another Kinase.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Agashe RP,
|
||
Lippman SM,
|
||
Kurzrock R</span><br />
|
||
<span class="medgenPMjournal">Mol Cancer Ther</span>
|
||
2022 Dec 2;21(12):1757-1764.
|
||
doi: 10.1158/1535-7163.MCT-22-0323.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36252553" target="_blank">36252553</a><a href="/pmc/articles/PMC10441554" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20940419">A potential role for α-actinin in inside-out αIIbβ3 signaling.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tadokoro S,
|
||
Nakazawa T,
|
||
Kamae T,
|
||
Kiyomizu K,
|
||
Kashiwagi H,
|
||
Honda S,
|
||
Kanakura Y,
|
||
Tomiyama Y</span><br />
|
||
<span class="medgenPMjournal">Blood</span>
|
||
2011 Jan 6;117(1):250-8.
|
||
Epub 2010 Oct 12
|
||
doi: 10.1182/blood-2009-10-246751.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20940419" target="_blank">20940419</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19698926">Gene expression profiling in acute myeloid leukaemia (AML).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bacher U,
|
||
Kohlmann A,
|
||
Haferlach C,
|
||
Haferlach T</span><br />
|
||
<span class="medgenPMjournal">Best Pract Res Clin Haematol</span>
|
||
2009 Jun;22(2):169-80.
|
||
doi: 10.1016/j.beha.2009.04.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19698926" target="_blank">19698926</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16840187">Transcription factor GATA-1 and Down syndrome leukemogenesis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Muntean AG,
|
||
Ge Y,
|
||
Taub JW,
|
||
Crispino JD</span><br />
|
||
<span class="medgenPMjournal">Leuk Lymphoma</span>
|
||
2006 Jun;47(6):986-97.
|
||
doi: 10.1080/10428190500485810.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16840187" target="_blank">16840187</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acute%20megakaryoblastic%20leukemia%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (160)</a></div></div>
|
||
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|
||
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0023462%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (1)</a></li>
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<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0023462%5bDISCUI%5d" target="_blank">See all (1)</a></total></li>
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<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0023462[DISCUI]" ref="log$=recordlinks">GTR</a>
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<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
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<a href="https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office" class="text-white">FOIA</a><br />
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