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<!--
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||
UID=4390
|
||
ConceptID=C0013144
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Drowsiness</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>4390</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0013144</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Abnormal drowsiness; Drowsiness, function; Drowsy; Mental status, drowsy; Sleepiness; Sleepy; Somnolence; Somnolence (sleepiness)</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Drowsiness (79519003); Sleepiness (79519003); Drowsiness, function (79519003); Mental status, drowsy (271782001); Somnolence (sleepiness) (271782001); Sleepy (271782001); Drowsiness (271782001); Sleepiness (271782001); Drowsy (271782001)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0002329">HP:0002329</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">Abnormal feeling of sleepiness or difficulty staying awake. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Drowsiness</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/1254" ref="tree=MeSH" title="MedGen record for Fetal anomaly">Fetal anomaly</a></span><ul><li><span class="TLline"><a href="/medgen/474891" ref="tree=MeSH" title="MedGen record for Congenital Systemic Disorder">Congenital Systemic Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/105425" ref="tree=MeSH" title="MedGen record for Abnormality of the nervous system">Abnormality of the nervous system</a></span><ul><li><span class="TLline"><a href="/medgen/868417" ref="tree=MeSH" title="MedGen record for Abnormal nervous system physiology">Abnormal nervous system physiology</a></span><ul><li><span class="TLline"><a href="/medgen/868938" ref="tree=MeSH" title="MedGen record for Abnormality of mental function">Abnormality of mental function</a></span><ul><li><span class="TLline"><a href="/medgen/482519" ref="tree=MeSH" title="MedGen record for Reduced consciousness">Reduced consciousness</a></span><ul><li><span class="matched_ds">Drowsiness</span><ul><li><span class="TLline"><a href="/medgen/871232" ref="tree=MeSH" title="MedGen record for Paroxysmal drowsiness">Paroxysmal drowsiness</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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</div>
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<div class="portlet mgSection" id="ID_112">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln clinfeat">
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||
<div class="divPopper rprt" id="rdis_120652"><div><strong>Hypervalinemia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>120652</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0268573</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Valinemia is an inborn error of metabolism characterized clinically by vomiting, feeding difficulties, hypotonia, and developmental delay, and biochemically by high concentrations of valine in serum and urine (Wada, 1965).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/120652">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_78692"><div><strong>Deficiency of hydroxymethylglutaryl-CoA lyase</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>78692</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0268601</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">3-Hydroxy-3-methylglutaryl-CoA lyase deficiency (HMGCLD) is a rare autosomal recessive disorder with the cardinal manifestations of metabolic acidosis without ketonuria, hypoglycemia, and a characteristic pattern of elevated urinary organic acid metabolites, including 3-hydroxy-3-methylglutaric, 3-methylglutaric, and 3-hydroxyisovaleric acids. Urinary levels of 3-methylcrotonylglycine may be increased. Dicarboxylic aciduria, hepatomegaly, and hyperammonemia may also be observed. Presenting clinical signs include irritability, lethargy, coma, and vomiting (summary by Gibson et al., 1988).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/78692">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_78724"><div><strong>Alexander disease</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>78724</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0270726</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Alexander disease, a progressive disorder of cerebral white matter caused by a heterozygous GFAP pathogenic variant, comprises a continuous clinical spectrum most recognizable in infants and children and a range of nonspecific neurologic manifestations in adults. This chapter discusses the spectrum of Alexander disease as four forms: neonatal, infantile, juvenile, and adult. The neonatal form begins in the first 30 days after birth with neurologic findings (e.g., hypotonia, hyperexcitability, myoclonus) and/or gastrointestinal manifestations (e.g., gastroesophageal reflux, vomiting, failure to thrive), followed by severe developmental delay and regression, seizures, megalencephaly, and typically death within two years. The infantile form is characterized by variable developmental issues: initially some have delayed or plateauing of acquisition of new skills, followed in some by a loss of gross and fine motor skills and language during in the first decade or in others a slow disease course that spans decades. Seizures, often triggered by illness, may be less frequent/severe than in the neonatal form. The juvenile form typically presents in childhood or adolescence with clinical and imaging features that overlap with the other forms. Manifestations in early childhood are milder than those in the infantile form (e.g., mild language delay may be the only developmental abnormality or, with language acquisition, hypophonia or nasal speech may alter the voice, often prior to appearance of other neurologic features). Vomiting and failure to thrive as well as scoliosis and autonomic dysfunction are common. The adult form is typically characterized by bulbar or pseudobulbar findings (palatal myoclonus, dysphagia, dysphonia, dysarthria or slurred speech), motor/gait abnormalities with pyramidal tract signs (spasticity, hyperreflexia, positive Babinski sign), or cerebellar abnormalities (ataxia, nystagmus, or dysmetria). Others may have hemiparesis or hemiplegia with a relapsing/remitting course or slowly progressive quadriparesis or quadriplegia. Other neurologic features can include sleep apnea, diplopia or disorders of extraocular motility, and autonomic dysfunction.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/78724">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_82888"><div><strong>Leucine-induced hypoglycemia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>82888</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0271714</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Leucine-sensitive hypoglycemia (LIH) is a condition in which symptomatic hypoglycemia is provoked by protein meals or the amino acid leucine (summary by Magge et al., 2004).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/82888">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_331388"><div><strong>Migraine, familial hemiplegic, 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>331388</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1832884</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial hemiplegic migraine (FHM) falls within the category of migraine with aura. In migraine with aura (including FHM) the neurologic symptoms of aura are unequivocally localizable to the cerebral cortex or brain stem and include visual disturbance (most common), sensory loss (e.g., numbness or paresthesias of the face or an extremity), and dysphasia (difficulty with speech). FHM must include motor involvement, such as hemiparesis (weakness of an extremity). Hemiparesis occurs with at least one other symptom during FHM aura. Neurologic deficits with FHM attacks can be prolonged for hours to days and may outlast the associated migrainous headache. FHM is often earlier in onset than typical migraine, frequently beginning in the first or second decade; the frequency of attacks tends to decrease with age. Approximately 40%-50% of families with CACNA1A-FHM have cerebellar signs ranging from nystagmus to progressive, usually late-onset mild ataxia.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/331388">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_355962"><div><strong>Migraine, familial hemiplegic, 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>355962</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1865322</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial hemiplegic migraine (FHM) falls within the category of migraine with aura. In migraine with aura (including FHM) the neurologic symptoms of aura are unequivocally localizable to the cerebral cortex or brain stem and include visual disturbance (most common), sensory loss (e.g., numbness or paresthesias of the face or an extremity), and dysphasia (difficulty with speech). FHM must include motor involvement, such as hemiparesis (weakness of an extremity). Hemiparesis occurs with at least one other symptom during FHM aura. Neurologic deficits with FHM attacks can be prolonged for hours to days and may outlast the associated migrainous headache. FHM is often earlier in onset than typical migraine, frequently beginning in the first or second decade; the frequency of attacks tends to decrease with age. Approximately 40%-50% of families with CACNA1A-FHM have cerebellar signs ranging from nystagmus to progressive, usually late-onset mild ataxia.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/355962">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_482447"><div><strong>Congenital nongoitrous hypothyroidism 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>482447</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3280817</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Any hypothyroidism, congenital, nongoitrous in which the cause of the disease is a mutation in the THRA gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/482447">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1636069"><div><strong>Epilepsy, hot water, 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1636069</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4551550</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1636069">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1648466"><div><strong>Mitochondrial complex 1 deficiency, nuclear type 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1648466</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4748737</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1648466">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1677730"><div><strong>Leukoencephalopathy, acute reversible, with increased urinary alpha-ketoglutarate</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1677730</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5193068</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Acute reversible leukoencephalopathy with increased urinary alpha-ketoglutarate (ARLIAK) is an autosomal recessive disorder characterized by acute reversible neurologic deterioration in the context of a febrile illness. The disorder is associated with transient leukoencephalopathy on brain imaging concurrent with the acute episode, as well as persistently increased excretion of dicarboxylic acids, particularly alpha-ketoglutarate (summary by Dewulf et al., 2019).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1677730">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1847194"><div><strong>Neurodevelopmental disorder with impaired language, behavioral abnormalities, and dysmorphic facies</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1847194</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5882686</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Neurodevelopmental disorder with impaired language, behavioral abnormalities, and dysmorphic facies (NEDLBF) is characterized by global developmental delay, speech delay, variably impaired intellectual development, behavioral abnormalities, and dysmorphic facial features. The phenotype and severity of the disorder is heterogeneous, ranging from borderline to severe. Brain imaging is usually normal. More variable additional features include early feeding difficulties, failure to thrive, short stature, mild visual impairment, hypotonia, seizures (particularly febrile), and distal skeletal defects of the hands and feet (Jia et al., 2022).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1847194">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_78724" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Alexander disease</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_482447" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Congenital nongoitrous hypothyroidism 6</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_78692" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Deficiency of hydroxymethylglutaryl-CoA lyase</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1636069" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Epilepsy, hot water, 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_120652" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypervalinemia</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (11)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_82888" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Leucine-induced hypoglycemia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1677730" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Leukoencephalopathy, acute reversible, with increased urinary alpha-ketoglutarate</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_331388" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Migraine, familial hemiplegic, 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_355962" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Migraine, familial hemiplegic, 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1648466" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Mitochondrial complex 1 deficiency, nuclear type 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1847194" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neurodevelopmental disorder with impaired language, behavioral abnormalities, and dysmorphic facies</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38420865">Treatment of acute urticaria: A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Badloe FMS,
|
||
Grosber M,
|
||
Ring J,
|
||
Kortekaas Krohn I,
|
||
Gutermuth J</span><br />
|
||
<span class="medgenPMjournal">J Eur Acad Dermatol Venereol</span>
|
||
2024 Nov;38(11):2082-2092.
|
||
Epub 2024 Feb 29
|
||
doi: 10.1111/jdv.19904.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38420865" target="_blank">38420865</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30626077">Antihistamines for Allergic Rhinitis Treatment from the Viewpoint of Nonsedative Properties.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kawauchi H,
|
||
Yanai K,
|
||
Wang DY,
|
||
Itahashi K,
|
||
Okubo K</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2019 Jan 8;20(1)
|
||
doi: 10.3390/ijms20010213.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30626077" target="_blank">30626077</a><a href="/pmc/articles/PMC6337346" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29781504">Epidural versus non-epidural or no analgesia for pain management in labour.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Anim-Somuah M,
|
||
Smyth RM,
|
||
Cyna AM,
|
||
Cuthbert A</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2018 May 21;5(5):CD000331.
|
||
doi: 10.1002/14651858.CD000331.pub4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29781504" target="_blank">29781504</a><a href="/pmc/articles/PMC6494646" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22drowsiness%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (301)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34067981">Pseudoephedrine-Benefits and Risks.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Głowacka K,
|
||
Wiela-Hojeńska A</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2021 May 13;22(10)
|
||
doi: 10.3390/ijms22105146.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34067981" target="_blank">34067981</a><a href="/pmc/articles/PMC8152226" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28778244">Hypersomnolence and Traffic Safety.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gupta R,
|
||
Pandi-Perumal SR,
|
||
Almeneessier AS,
|
||
BaHammam AS</span><br />
|
||
<span class="medgenPMjournal">Sleep Med Clin</span>
|
||
2017 Sep;12(3):489-499.
|
||
Epub 2017 Jun 8
|
||
doi: 10.1016/j.jsmc.2017.03.018.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28778244" target="_blank">28778244</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28341079">Monitoring of nociception, reality or fiction?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Abad-Gurumeta A,
|
||
Ripollés-Melchor J,
|
||
Casans-Francés R,
|
||
Calvo-Vecino JM</span><br />
|
||
<span class="medgenPMjournal">Rev Esp Anestesiol Reanim</span>
|
||
2017 Aug-Sep;64(7):406-414.
|
||
Epub 2017 Mar 22
|
||
doi: 10.1016/j.redar.2017.01.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28341079" target="_blank">28341079</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25759004">In Search of a Safe Natural Sleep Aid.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rao TP,
|
||
Ozeki M,
|
||
Juneja LR</span><br />
|
||
<span class="medgenPMjournal">J Am Coll Nutr</span>
|
||
2015;34(5):436-47.
|
||
Epub 2015 Mar 11
|
||
doi: 10.1080/07315724.2014.926153.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25759004" target="_blank">25759004</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17313339">Vigilance monitoring--review and practical aspects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Canisius S,
|
||
Penzel T</span><br />
|
||
<span class="medgenPMjournal">Biomed Tech (Berl)</span>
|
||
2007 Feb;52(1):77-82.
|
||
doi: 10.1515/BMT.2007.015.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17313339" target="_blank">17313339</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Drowsiness%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2415)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38393799">Treatment of Chronic Insomnia in Adults.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Matheson EM,
|
||
Brown BD,
|
||
DeCastro AO</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2024 Feb;109(2):154-160.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38393799" target="_blank">38393799</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33487328">Woman With Fever and Drowsiness.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tu SY,
|
||
Chen HC,
|
||
Tsai JP,
|
||
Tsai TY</span><br />
|
||
<span class="medgenPMjournal">Ann Emerg Med</span>
|
||
2021 Feb;77(2):e71-e72.
|
||
doi: 10.1016/j.annemergmed.2020.07.013.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33487328" target="_blank">33487328</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31375202">Precision Medicine for Idiopathic Hypersomnia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Arnulf I,
|
||
Leu-Semenescu S,
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<div class="nl"><a target="_blank" href="/pubmed/35717988">Opioid versus opioid-free analgesia after surgical discharge: a systematic review and meta-analysis of randomised trials.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Fiore JF Jr,
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El-Kefraoui C,
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Chay MA,
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Nguyen-Powanda P,
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Do U,
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Olleik G,
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Rajabiyazdi F,
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Kouyoumdjian A,
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Derksen A,
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Landry T,
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Amar-Zifkin A,
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Bergeron A,
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Ramanakumar AV,
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Martel M,
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Lee L,
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Baldini G,
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2022 Jun 18;399(10343):2280-2293.
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<div class="nl"><a target="_blank" href="/pubmed/29781504">Epidural versus non-epidural or no analgesia for pain management in labour.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Anim-Somuah M,
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Smyth RM,
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<div class="portlet_content ln"><span class="medgenPMauthor">Whiting PF,
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Wolff RF,
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Deshpande S,
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Di Nisio M,
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Duffy S,
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Hernandez AV,
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Keurentjes JC,
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Lang S,
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Misso K,
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Ryder S,
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Schmidlkofer S,
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Westwood M,
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Kleijnen J</span><br />
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<div class="nl"><a target="_blank" href="/pubmed/1919653">Otitis externa malignum.</a></div>
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Kao CL,
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Hsing CH,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Drowsiness%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1969)</a></div></div>
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</div>
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<div class="portlet mgSection" id="ID_104">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/35717988">Opioid versus opioid-free analgesia after surgical discharge: a systematic review and meta-analysis of randomised trials.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fiore JF Jr,
|
||
El-Kefraoui C,
|
||
Chay MA,
|
||
Nguyen-Powanda P,
|
||
Do U,
|
||
Olleik G,
|
||
Rajabiyazdi F,
|
||
Kouyoumdjian A,
|
||
Derksen A,
|
||
Landry T,
|
||
Amar-Zifkin A,
|
||
Bergeron A,
|
||
Ramanakumar AV,
|
||
Martel M,
|
||
Lee L,
|
||
Baldini G,
|
||
Feldman LS</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2022 Jun 18;399(10343):2280-2293.
|
||
doi: 10.1016/S0140-6736(22)00582-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35717988" target="_blank">35717988</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34497047">Medical cannabis or cannabinoids for chronic non-cancer and cancer related pain: a systematic review and meta-analysis of randomised clinical trials.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang L,
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Hong PJ,
|
||
May C,
|
||
Rehman Y,
|
||
Oparin Y,
|
||
Hong CJ,
|
||
Hong BY,
|
||
AminiLari M,
|
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Gallo L,
|
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Kaushal A,
|
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Craigie S,
|
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Couban RJ,
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Kum E,
|
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Shanthanna H,
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Price I,
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Upadhye S,
|
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Ware MA,
|
||
Campbell F,
|
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Buchbinder R,
|
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Agoritsas T,
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Busse JW</span><br />
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<span class="medgenPMjournal">BMJ</span>
|
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2021 Sep 8;374:n1034.
|
||
doi: 10.1136/bmj.n1034.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34497047" target="_blank">34497047</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29781504">Epidural versus non-epidural or no analgesia for pain management in labour.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Anim-Somuah M,
|
||
Smyth RM,
|
||
Cyna AM,
|
||
Cuthbert A</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2018 May 21;5(5):CD000331.
|
||
doi: 10.1002/14651858.CD000331.pub4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29781504" target="_blank">29781504</a><a href="/pmc/articles/PMC6494646" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27737513">Pharmacologic interventions for treating phantom limb pain.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Alviar MJ,
|
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Hale T,
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Dungca M</span><br />
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<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
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2016 Oct 14;10(10):CD006380.
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<span class="bold">PMID: </span><a href="/pubmed/27737513" target="_blank">27737513</a><a href="/pmc/articles/PMC6472447" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26103030">Cannabinoids for Medical Use: A Systematic Review and Meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Whiting PF,
|
||
Wolff RF,
|
||
Deshpande S,
|
||
Di Nisio M,
|
||
Duffy S,
|
||
Hernandez AV,
|
||
Keurentjes JC,
|
||
Lang S,
|
||
Misso K,
|
||
Ryder S,
|
||
Schmidlkofer S,
|
||
Westwood M,
|
||
Kleijnen J</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2015 Jun 23-30;313(24):2456-73.
|
||
doi: 10.1001/jama.2015.6358.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26103030" target="_blank">26103030</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Drowsiness%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (199)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
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|
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|
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|
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<div class="supplemental col three_col last">
|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
|
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Drowsiness" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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