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<!--
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||
UID=43803
|
||
ConceptID=C0020651
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Orthostatic hypotension</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>43803</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0020651</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Orthostatic hypotension (disease)</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Orthostatic hypotension (28651003); Postural hypotension (28651003)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0001278">HP:0001278</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0005469" target="_blank">MONDO:0005469</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/146500" target="_blank">146500</a></td></tr>
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||
<div class="portlet_content ln">A form of hypotension characterized by a sudden fall in blood pressure that occurs when a person assumes a standing position. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=43803" target="_blank" href="/omim/146500">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Orthostatic hypotension</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/1254" ref="tree=MeSH" title="MedGen record for Fetal anomaly">Fetal anomaly</a></span><ul><li><span class="TLline"><a href="/medgen/474891" ref="tree=MeSH" title="MedGen record for Congenital Systemic Disorder">Congenital Systemic Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/105425" ref="tree=MeSH" title="MedGen record for Abnormality of the nervous system">Abnormality of the nervous system</a></span><ul><li><span class="TLline"><a href="/medgen/892810" ref="tree=MeSH" title="MedGen record for Abnormality of the peripheral nervous system">Abnormality of the peripheral nervous system</a></span><ul><li><span class="TLline"><a href="/medgen/871233" ref="tree=MeSH" title="MedGen record for Abnormality of the autonomic nervous system">Abnormality of the autonomic nervous system</a></span><ul><li><span class="TLline"><a href="/medgen/8511" ref="tree=MeSH" title="MedGen record for Abnormal autonomic nervous system physiology">Abnormal autonomic nervous system physiology</a></span><ul><li><span class="matched_ds">Orthostatic hypotension</span><ul><li><span class="TLline"><a href="/medgen/1729466" ref="tree=MeSH" title="MedGen record for Neurogenic Orthostatic Hypotension">Neurogenic Orthostatic Hypotension</a></span></li><li><span class="TLline"><a href="/medgen/358344" ref="tree=MeSH" title="MedGen record for Orthostatic hypotension due to autonomic dysfunction">Orthostatic hypotension due to autonomic dysfunction</a></span></li><li><span class="TLline"><a href="/medgen/376790" ref="tree=MeSH" title="MedGen record for Postural hypotension with compensatory tachycardia">Postural hypotension with compensatory tachycardia</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln clinfeat">
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||
<div class="divPopper rprt" id="rdis_41678"><div><strong>Familial dysautonomia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>41678</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0013364</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial dysautonomia, which affects the development and survival of sensory, sympathetic, and parasympathetic neurons, is a debilitating disorder present from birth. Neuronal degeneration progresses throughout life. Affected individuals have gastrointestinal dysfunction, autonomic crises (i.e., hypertensive vomiting attacks), recurrent pneumonia, altered pain sensitivity, altered temperature perception, and blood pressure instability. Hypotonia contributes to delay in acquisition of motor milestones. Optic neuropathy results in progressive vision loss. Older individuals often have a broad-based and ataxic gait that deteriorates over time. Developmental delay / intellectual disability occur in about 21% of individuals. Life expectancy is decreased.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/41678">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_11313"><div><strong>Sandhoff disease</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>11313</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0036161</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Sandhoff disease comprises a phenotypic continuum encompassing acute infantile, subacute juvenile, and late-onset disease. Although classification into these phenotypes is somewhat arbitrary, it is helpful in understanding the variation observed in the timing of disease onset, presenting manifestations, rate of progression, and life span. Acute infantile Sandhoff disease (onset age <6 months). Infants are generally normal at birth followed by progressive weakness and slowing of developmental progress, then developmental regression and severe neurologic impairment. Seizures are common. Death usually occurs between ages two and three years. Subacute juvenile Sandhoff disease (onset age 2-5 years). After attaining normal developmental milestones, developmental progress slows, followed by developmental regression and neurologic impairment (abnormal gait, dysarthria, and cognitive decline). Death (usually from aspiration) typically occurs in the early to late teens. Late-onset Sandhoff disease (onset older teen years or young adulthood). Nearly normal psychomotor development is followed by a range of neurologic findings (e.g., weakness, spasticity, dysarthria, and deficits in cerebellar function) and psychiatric findings (e.g., deficits in executive function and memory). Life expectancy is not necessarily decreased.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/11313">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_82793"><div><strong>Cutis laxa, X-linked</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>82793</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0268353</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Occipital horn syndrome (OHS) is a rare connective tissue disorder characterized by hyperelastic and bruisable skin, hernias, bladder diverticula, hyperextensible joints, varicosities, and multiple skeletal abnormalities. The disorder is sometimes accompanied by mild neurologic impairment, and bony abnormalities of the occiput are a common feature, giving rise to the name (summary by Das et al., 1995).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/82793">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_82889"><div><strong>Glucocorticoid deficiency with achalasia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>82889</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0271742</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Triple A syndrome is an inherited condition characterized by three specific features: achalasia, Addison disease, and alacrima. Achalasia is a disorder that affects the ability to move food through the esophagus, the tube that carries food from the throat to the stomach. It can lead to severe feeding difficulties and low blood glucose (hypoglycemia). Addison disease, also known as primary adrenal insufficiency, is caused by abnormal function of the small hormone-producing glands on top of each kidney (adrenal glands). The main features of Addison disease include fatigue, loss of appetite, weight loss, low blood pressure, and darkening of the skin. The third major feature of triple A syndrome is a reduced or absent ability to secrete tears (alacrima). Most people with triple A syndrome have all three of these features, although some have only two.\n\nMany of the features of triple A syndrome are caused by dysfunction of the autonomic nervous system. This part of the nervous system controls involuntary body processes such as digestion, blood pressure, and body temperature. People with triple A syndrome often experience abnormal sweating, difficulty regulating blood pressure, unequal pupil size (anisocoria), and other signs and symptoms of autonomic nervous system dysfunction (dysautonomia).\n\nPeople with this condition may have other neurological abnormalities, such as developmental delay, intellectual disability, speech problems (dysarthria), and a small head size (microcephaly). In addition, affected individuals commonly experience muscle weakness, movement problems, and nerve abnormalities in their extremities (peripheral neuropathy). Some develop optic atrophy, which is the degeneration (atrophy) of the nerves that carry information from the eyes to the brain. Many of the neurological symptoms of triple A syndrome worsen over time.\n\nPeople with triple A syndrome frequently develop a thickening of the outer layer of skin (hyperkeratosis) on the palms of their hands and the soles of their feet. Other skin abnormalities may also be present in people with this condition.\n\nAlacrima is usually the first noticeable sign of triple A syndrome, as it becomes apparent early in life that affected children produce little or no tears while crying. They develop Addison disease and achalasia during childhood or adolescence, and most of the neurologic features of triple A syndrome begin during adulthood. The signs and symptoms of this condition vary among affected individuals, even among members of the same family.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/82889">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_301243"><div><strong>Finnish type amyloidosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>301243</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1622345</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">The Finnish type of systemic amyloidosis is characterized clinically by a unique constellation of features including lattice corneal dystrophy, and cranial neuropathy, bulbar signs, and skin changes. Some patients may develop peripheral neuropathy and renal failure. The disorder is usually inherited in an autosomal dominant pattern; however, homozygotes with a more severe phenotype have also been reported (Meretoja, 1973). Finnish hereditary amyloidosis, also known as Meretoja syndrome or AGel amyloidosis, is one of the most common diseases in the Finnish disease heritage. Symptoms commonly appear by age 40, with the first finding usually corneal lattice dystrophy (CLD), diagnosed by an ophthalmologist. Impaired vision, polyneuropathy, facial nerve paresis, and cutis laxa follow. These symptoms may develop slowly and simultaneously, since amyloid accumulates systemically at a constant rate (summary by Nikoskinen et al., 2015). For a discussion of genetic heterogeneity of hereditary systemic amyloidosis, see AMYLD1 (105210).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/301243">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_327101"><div><strong>Orthostatic hypotensive disorder, Streeten type</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>327101</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1840438</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/327101">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_342338"><div><strong>Adult polyglucosan body disease</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>342338</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1849722</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Most individuals with classic GBE1 adult polyglucosan body disease (GBE1-APBD) present after age 40 years with unexplained progressive neurogenic bladder, gait difficulties (i.e., spasticity and weakness) from mixed upper and lower motor neuron involvement, sensory loss predominantly in the distal lower extremities, autonomic dysfunction (associated with orthostatic hypotension and constipation), and mild cognitive difficulties (often executive dysfunction). Some affected individuals without classic GBE1-APBD have atypical phenotypes including Alzheimer disease-like dementia and axonal neuropathy, stroke-like episodes, and diaphragmatic failure; others may have a history of infantile liver disease.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/342338">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_381361"><div><strong>Autosomal dominant Parkinson disease 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>381361</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1854182</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Parkinson's disease is a progressive disorder of the nervous system. The disorder affects several regions of the brain, especially an area called the substantia nigra that controls balance and movement.\n\nGenerally, Parkinson's disease that begins after age 50 is called late-onset disease. The condition is described as early-onset disease if signs and symptoms begin before age 50. Early-onset cases that begin before age 20 are sometimes referred to as juvenile-onset Parkinson's disease.\n\nOften the first symptom of Parkinson's disease is trembling or shaking (tremor) of a limb, especially when the body is at rest. Typically, the tremor begins on one side of the body, usually in one hand. Tremors can also affect the arms, legs, feet, and face. Other characteristic symptoms of Parkinson's disease include rigidity or stiffness of the limbs and torso, slow movement (bradykinesia) or an inability to move (akinesia), and impaired balance and coordination (postural instability). These symptoms worsen slowly over time.\n\nParkinson's disease can also affect emotions and thinking ability (cognition). Some affected individuals develop psychiatric conditions such as depression and visual hallucinations. People with Parkinson's disease also have an increased risk of developing dementia, which is a decline in intellectual functions including judgment and memory.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/381361">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_483046"><div><strong>Corticosterone methyloxidase type 2 deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>483046</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3463917</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">CMO type II deficiency is an autosomal recessive disorder caused by a defect in the final biochemical step of aldosterone biosynthesis, the 18-hydroxylation of 18-hydroxycorticosterone (18-OHB) to aldosterone. This enzymatic defect results in decreased aldosterone and salt-wasting associated with an increased serum ratio of 18-OHB to aldosterone. In CMO II deficiency, aldosterone can be low or normal, but at the expense of increased secretion of 18-OHB. These patients have a low ratio of corticosterone to 18-OHB (Portrat-Doyen et al., 1998). The CYP11B2 gene product also catalyzes an earlier step in aldosterone biosynthesis: the 18-hydroxylation of corticosterone to 18-OHB. A defect in that enzymatic step results in CMO type I deficiency (204300), an allelic disorder with an overlapping phenotype but distinct biochemical features. In CMO I deficiency, aldosterone is undetectable, whereas its immediate precursor, 18-OHB, is low or normal (Portrat-Doyen et al., 1998).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/483046">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_811503"><div><strong>Multiple system atrophy 1, susceptibility to</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>811503</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3714927</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">Multiple system atrophy (MSA) is a distinct clinicopathologic entity that manifests as a progressive adult-onset neurodegenerative disorder causing parkinsonism, cerebellar ataxia, and autonomic, urogenital, and pyramidal dysfunction in various combinations. Two main subtypes are recognized: 'subtype C,' characterized predominantly by cerebellar ataxia, and 'subtype P,' characterized predominantly by parkinsonism. MSA is characterized pathologically by the degeneration of striatonigral and olivopontocerebellar structures and glial cytoplasmic inclusions (GCIs) that consist of abnormally phosphorylated alpha-synuclein (SNCA; 163890) or tau (MAPT; 157140) (Gilman et al., 1998; Gilman et al., 2008; Scholz et al., 2009). 'Subtype C' of MSA has been reported to be more prevalent than 'subtype P' in the Japanese population (65-67% vs 33-35%), whereas 'subtype P' has been reported to be more prevalent than 'subtype C' in Europe (63% vs 34%) and North America (60% vs 13%, with 27% of cases unclassified) (summary by The Multiple-System Atrophy Research Collaboration, 2013). MSA is similar clinically and pathologically to Parkinson disease (PD; 168600) and Lewy body dementia (127750). See also PARK1 (168601), which is specifically caused by mutation in the SNCA gene. Pure autonomic failure manifests as orthostatic hypotension and other autonomic abnormalities without other neurologic involvement. Although there is some phenotypic overlap, the relationship of pure autonomic failure to MSA is unclear (Vanderhaeghen et al., 1970; Schatz, 1996).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/811503">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_813897"><div><strong>Partial lipodystrophy, congenital cataracts, and neurodegeneration syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>813897</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3807567</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Lipodystrophies are rare disorders characterized by loss of body fat from various regions and predisposition to metabolic complications of insulin resistance and lipid abnormalities. FPLD7 is an autosomal dominant disorder with a highly variable phenotype. Additional features, including early-onset cataracts and later onset of spasticity of the lower limbs, have been noted in some patients (summary by Garg et al., 2015). For a general phenotypic description and a discussion of genetic heterogeneity of familial partial lipodystrophy (FPLD), see 151660.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/813897">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_907886"><div><strong>Parkinson disease 22, autosomal dominant</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>907886</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4225238</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Any Parkinson disease in which the cause of the disease is a mutation in the CHCHD2 gene.</div>
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||
<div class="spaceAbove nowrap">See: <a href="/medgen/907886">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_1640947"><div><strong>Alacrima, achalasia, and intellectual disability syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1640947</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4706563</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Alacrima, achalasia, and impaired intellectual development syndrome (AAMR) is an autosomal recessive disorder characterized by onset of these 3 main features at birth or in early infancy. More variable features include hypotonia, gait abnormalities, anisocoria, and visual or hearing deficits. The disorder shows similarity to the triple A syndrome (231550), but patients with AAMR do not have adrenal insufficiency (summary by Koehler et al., 2013). See also 300858 for a phenotypically similar disorder that shows X-linked inheritance.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/1640947">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_1648402"><div><strong>Orthostatic hypotension 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1648402</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4746777</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Dopamine beta-hydroxylase (DBH) deficiency is characterized by lack of sympathetic noradrenergic function resulting in profound deficits in autonomic regulation of cardiovascular function (orthostatic hypotension) and other autonomic dysfunction (ptosis, nasal stuffiness, sleep difficulties, and impaired ejaculation in males). Although DBH deficiency is present from birth, the diagnosis is often not generally recognized until late childhood. In the perinatal period, DBH deficiency has been complicated by vomiting, dehydration, hypotension, hypothermia, and hypoglycemia requiring repeated hospitalization, and the diagnosis may be identified fortuitously in the neonatal period with investigation of hypoglycemia. Children may report reduced exercise capacity. By early adulthood, individuals have profound orthostatic hypotension, greatly reduced exercise tolerance, ptosis, and nasal stuffiness. Presyncopal symptoms include dizziness, blurred vision, dyspnea, nuchal discomfort, and chest pain; symptoms may worsen in hot environments or after heavy meals or alcohol ingestion. Some individuals have abnormal kidney function, joint laxity, hypotonia, high-arched palate, anemia, and/or hypoglycemia.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/1648402">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_1648282"><div><strong>Orthostatic hypotension 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1648282</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4748569</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Orthostatic hypotension-2 is an autosomal recessive disorder characterized by severe orthostatic hypotension, recurrent hypoglycemia, and low norepinephrine levels. The disorder has onset in infancy or early childhood. Some patients may also have renal dysfunction and reduced life expectancy. The disorder results from a defect in the biosynthesis of norepinephrine from dopamine due to a cofactor deficiency. For a discussion of genetic heterogeneity of ORTHYP, see ORTHYP1 (223360).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/1648282">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_1684829"><div><strong>Urinary bladder, atony of</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1684829</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5231389</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Autonomic bladder dysfunction with impaired pupillary reflex and secondary CAKUT (congenital anomalies of the kidney and urinary tract) is an autosomal recessive neurogenic disorder with onset in utero or early childhood. Affected individuals have impaired neuronal bladder and ureteral innervation causing coordination defects that result in secondary structural defects of the renal system, including hydronephrosis, vesicoureteral reflux (VUR), and small kidneys, that may result in chronic kidney disease as well as recurrent urinary tract infections (UTIs). Surgical treatment of VUR is not effective. Most individuals also have additional autonomic features, most commonly impaired pupillary reflex and sometimes orthostatic hypotension (summary by Mann et al., 2019).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/1684829">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_1860723"><div><strong>Amyloidosis, hereditary systemic 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1860723</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5935573</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Hereditary systemic amyloidosis-6 (AMYLD6) is an autosomal dominant systemic amyloidosis characterized by onset in middle age of gastrointestinal and cardiac symptoms resulting from progressive amyloid deposition. Neurologic involvement, sicca syndrome, and carpal tunnel syndrome may also be present (summary by Prokaeva et al., 2022 and Haslett et al., 2023). For a discussion of genetic heterogeneity of hereditary systemic amyloidosis, see AMYLD1 (105210).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/1860723">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_1861832"><div><strong>Neurodevelopmental disorder with progressive movement abnormalities</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1861832</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5935606</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Neurodevelopmental disorder with progressive movement abnormalities (NEDPM) is an autosomal recessive complex neurologic disorder characterized by global developmental delay apparent from infancy, moderately to severely impaired intellectual development, poor or absent speech, behavioral abnormalities, and various hyperkinetic movement disorders, including dystonia, spasticity, and cerebellar ataxia, that interfere with gait and cause a stooped posture. The disorder appears to be progressive with age-related deterioration of cognitive and motor function; parkinsonism may develop in older patients. Additional more variable features include seizures, dysmorphic facial features, oculomotor defects, and brain imaging abnormalities (Kaiyrzhanov et al., 2024).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/1861832">Condition Record</a></div></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_342338" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Adult polyglucosan body disease</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1640947" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Alacrima, achalasia, and intellectual disability syndrome</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1860723" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Amyloidosis, hereditary systemic 6</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_381361" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal dominant Parkinson disease 4</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_483046" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Corticosterone methyloxidase type 2 deficiency</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (18)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_82793" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cutis laxa, X-linked</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_41678" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial dysautonomia</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_301243" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Finnish type amyloidosis</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_82889" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Glucocorticoid deficiency with achalasia</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_811503" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Multiple system atrophy 1, susceptibility to</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1861832" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neurodevelopmental disorder with progressive movement abnormalities</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1648402" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Orthostatic hypotension 1</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1648282" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Orthostatic hypotension 2</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_327101" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Orthostatic hypotensive disorder, Streeten type</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_907886" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Parkinson disease 22, autosomal dominant</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_813897" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Partial lipodystrophy, congenital cataracts, and neurodegeneration syndrome</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_11313" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Sandhoff disease</a></div>
|
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1684829" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Urinary bladder, atony of</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36400555">Dysautonomia: Diagnosis and Management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hovaguimian A</span><br />
|
||
<span class="medgenPMjournal">Neurol Clin</span>
|
||
2023 Feb;41(1):193-213.
|
||
Epub 2022 Oct 31
|
||
doi: 10.1016/j.ncl.2022.08.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36400555" target="_blank">36400555</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35841911">Diagnosis and treatment of orthostatic hypotension.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wieling W,
|
||
Kaufmann H,
|
||
Claydon VE,
|
||
van Wijnen VK,
|
||
Harms MPM,
|
||
Juraschek SP,
|
||
Thijs RD</span><br />
|
||
<span class="medgenPMjournal">Lancet Neurol</span>
|
||
2022 Aug;21(8):735-746.
|
||
doi: 10.1016/S1474-4422(22)00169-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35841911" target="_blank">35841911</a><a href="/pmc/articles/PMC10024337" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31809788">Autonomic dysfunction in Parkinson's disease: Implications for pathophysiology, diagnosis, and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chen Z,
|
||
Li G,
|
||
Liu J</span><br />
|
||
<span class="medgenPMjournal">Neurobiol Dis</span>
|
||
2020 Feb;134:104700.
|
||
Epub 2019 Dec 3
|
||
doi: 10.1016/j.nbd.2019.104700.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31809788" target="_blank">31809788</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22orthostatic%20hypotension%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (466)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37847274">Orthostatic Hypotension, Hypertension Treatment, and Cardiovascular Disease: An Individual Participant Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Juraschek SP,
|
||
Hu JR,
|
||
Cluett JL,
|
||
Ishak AM,
|
||
Mita C,
|
||
Lipsitz LA,
|
||
Appel LJ,
|
||
Beckett NS,
|
||
Coleman RL,
|
||
Cushman WC,
|
||
Davis BR,
|
||
Grandits G,
|
||
Holman RR,
|
||
Miller ER 3rd,
|
||
Peters R,
|
||
Staessen JA,
|
||
Taylor AA,
|
||
Thijs L,
|
||
Wright JT Jr,
|
||
Mukamal KJ</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2023 Oct 17;330(15):1459-1471.
|
||
doi: 10.1001/jama.2023.18497.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37847274" target="_blank">37847274</a><a href="/pmc/articles/PMC10582789" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35841911">Diagnosis and treatment of orthostatic hypotension.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wieling W,
|
||
Kaufmann H,
|
||
Claydon VE,
|
||
van Wijnen VK,
|
||
Harms MPM,
|
||
Juraschek SP,
|
||
Thijs RD</span><br />
|
||
<span class="medgenPMjournal">Lancet Neurol</span>
|
||
2022 Aug;21(8):735-746.
|
||
doi: 10.1016/S1474-4422(22)00169-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35841911" target="_blank">35841911</a><a href="/pmc/articles/PMC10024337" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34001585">Orthostatic hypotension in older people: considerations, diagnosis and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dani M,
|
||
Dirksen A,
|
||
Taraborrelli P,
|
||
Panagopolous D,
|
||
Torocastro M,
|
||
Sutton R,
|
||
Lim PB</span><br />
|
||
<span class="medgenPMjournal">Clin Med (Lond)</span>
|
||
2021 May;21(3):e275-e282.
|
||
doi: 10.7861/clinmed.2020-1044.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34001585" target="_blank">34001585</a><a href="/pmc/articles/PMC8140709" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32716319">Management of Orthostatic Hypotension in Parkinson's Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fanciulli A,
|
||
Leys F,
|
||
Falup-Pecurariu C,
|
||
Thijs R,
|
||
Wenning GK</span><br />
|
||
<span class="medgenPMjournal">J Parkinsons Dis</span>
|
||
2020;10(s1):S57-S64.
|
||
doi: 10.3233/JPD-202036.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32716319" target="_blank">32716319</a><a href="/pmc/articles/PMC7592655" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31996627">Management of Orthostatic Hypotension.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Palma JA,
|
||
Kaufmann H</span><br />
|
||
<span class="medgenPMjournal">Continuum (Minneap Minn)</span>
|
||
2020 Feb;26(1):154-177.
|
||
doi: 10.1212/CON.0000000000000816.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31996627" target="_blank">31996627</a><a href="/pmc/articles/PMC7339914" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Orthostatic%20hypotension%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2708)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35841911">Diagnosis and treatment of orthostatic hypotension.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wieling W,
|
||
Kaufmann H,
|
||
Claydon VE,
|
||
van Wijnen VK,
|
||
Harms MPM,
|
||
Juraschek SP,
|
||
Thijs RD</span><br />
|
||
<span class="medgenPMjournal">Lancet Neurol</span>
|
||
2022 Aug;21(8):735-746.
|
||
doi: 10.1016/S1474-4422(22)00169-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35841911" target="_blank">35841911</a><a href="/pmc/articles/PMC10024337" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35029960">Orthostatic Hypotension.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMjournal">Am Fam Physician</span>
|
||
2022 Jan 1;105(1):Online.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35029960" target="_blank">35029960</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34001585">Orthostatic hypotension in older people: considerations, diagnosis and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dani M,
|
||
Dirksen A,
|
||
Taraborrelli P,
|
||
Panagopolous D,
|
||
Torocastro M,
|
||
Sutton R,
|
||
Lim PB</span><br />
|
||
<span class="medgenPMjournal">Clin Med (Lond)</span>
|
||
2021 May;21(3):e275-e282.
|
||
doi: 10.7861/clinmed.2020-1044.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34001585" target="_blank">34001585</a><a href="/pmc/articles/PMC8140709" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31996627">Management of Orthostatic Hypotension.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Palma JA,
|
||
Kaufmann H</span><br />
|
||
<span class="medgenPMjournal">Continuum (Minneap Minn)</span>
|
||
2020 Feb;26(1):154-177.
|
||
doi: 10.1212/CON.0000000000000816.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31996627" target="_blank">31996627</a><a href="/pmc/articles/PMC7339914" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30190008">Orthostatic Hypotension: JACC State-of-the-Art Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Freeman R,
|
||
Abuzinadah AR,
|
||
Gibbons C,
|
||
Jones P,
|
||
Miglis MG,
|
||
Sinn DI</span><br />
|
||
<span class="medgenPMjournal">J Am Coll Cardiol</span>
|
||
2018 Sep 11;72(11):1294-1309.
|
||
doi: 10.1016/j.jacc.2018.05.079.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30190008" target="_blank">30190008</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Orthostatic%20hypotension%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2328)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38536167">Risk Assessment and Prevention of Falls in Older Community-Dwelling Adults: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Colón-Emeric CS,
|
||
McDermott CL,
|
||
Lee DS,
|
||
Berry SD</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2024 Apr 23;331(16):1397-1406.
|
||
doi: 10.1001/jama.2024.1416.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38536167" target="_blank">38536167</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34752479">Drug-induced orthostatic hypotension: A systematic review and meta-analysis of randomised controlled trials.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bhanu C,
|
||
Nimmons D,
|
||
Petersen I,
|
||
Orlu M,
|
||
Davis D,
|
||
Hussain H,
|
||
Magammanage S,
|
||
Walters K</span><br />
|
||
<span class="medgenPMjournal">PLoS Med</span>
|
||
2021 Nov;18(11):e1003821.
|
||
Epub 2021 Nov 9
|
||
doi: 10.1371/journal.pmed.1003821.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34752479" target="_blank">34752479</a><a href="/pmc/articles/PMC8577726" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32690803">Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yu JT,
|
||
Xu W,
|
||
Tan CC,
|
||
Andrieu S,
|
||
Suckling J,
|
||
Evangelou E,
|
||
Pan A,
|
||
Zhang C,
|
||
Jia J,
|
||
Feng L,
|
||
Kua EH,
|
||
Wang YJ,
|
||
Wang HF,
|
||
Tan MS,
|
||
Li JQ,
|
||
Hou XH,
|
||
Wan Y,
|
||
Tan L,
|
||
Mok V,
|
||
Tan L,
|
||
Dong Q,
|
||
Touchon J,
|
||
Gauthier S,
|
||
Aisen PS,
|
||
Vellas B</span><br />
|
||
<span class="medgenPMjournal">J Neurol Neurosurg Psychiatry</span>
|
||
2020 Nov;91(11):1201-1209.
|
||
Epub 2020 Jul 20
|
||
doi: 10.1136/jnnp-2019-321913.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32690803" target="_blank">32690803</a><a href="/pmc/articles/PMC7569385" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30583909">Orthostatic Hypotension and Falls in Older Adults: A Systematic Review and Meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mol A,
|
||
Bui Hoang PTS,
|
||
Sharmin S,
|
||
Reijnierse EM,
|
||
van Wezel RJA,
|
||
Meskers CGM,
|
||
Maier AB</span><br />
|
||
<span class="medgenPMjournal">J Am Med Dir Assoc</span>
|
||
2019 May;20(5):589-597.e5.
|
||
Epub 2018 Dec 21
|
||
doi: 10.1016/j.jamda.2018.11.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30583909" target="_blank">30583909</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30788010">Cardiac Autonomic Neuropathy in Diabetes Mellitus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Agashe S,
|
||
Petak S</span><br />
|
||
<span class="medgenPMjournal">Methodist Debakey Cardiovasc J</span>
|
||
2018 Oct-Dec;14(4):251-256.
|
||
doi: 10.14797/mdcj-14-4-251.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30788010" target="_blank">30788010</a><a href="/pmc/articles/PMC6369622" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Orthostatic%20hypotension%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2821)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35841911">Diagnosis and treatment of orthostatic hypotension.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wieling W,
|
||
Kaufmann H,
|
||
Claydon VE,
|
||
van Wijnen VK,
|
||
Harms MPM,
|
||
Juraschek SP,
|
||
Thijs RD</span><br />
|
||
<span class="medgenPMjournal">Lancet Neurol</span>
|
||
2022 Aug;21(8):735-746.
|
||
doi: 10.1016/S1474-4422(22)00169-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35841911" target="_blank">35841911</a><a href="/pmc/articles/PMC10024337" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33886735">Dysautonomia: A Forgotten Condition - Part 1.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Rocha EA,
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Mehta N,
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<span class="bold">PMID: </span><a href="/pubmed/33886735" target="_blank">33886735</a><a href="/pmc/articles/PMC8121406" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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<div class="nl"><a target="_blank" href="/pubmed/33513879">Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Didangelos T,
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Karlafti E,
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Margariti E,
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<div class="nl"><a target="_blank" href="/pubmed/28290647">Syncope: Evaluation and Differential Diagnosis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Runser LA,
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Gauer RL,
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Houser A</span><br />
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2017 Mar 1;95(5):303-312.
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<span class="bold">PMID: </span><a href="/pubmed/28290647" target="_blank">28290647</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/26271068">Orthostatic Hypotension: Epidemiology, Prognosis, and Treatment.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Ricci F,
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De Caterina R,
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<span class="medgenPMjournal">J Am Coll Cardiol</span>
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2015 Aug 18;66(7):848-860.
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doi: 10.1016/j.jacc.2015.06.1084.
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<span class="bold">PMID: </span><a href="/pubmed/26271068" target="_blank">26271068</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Orthostatic%20hypotension%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1059)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/33419664">Electrodiagnostic assessment of the autonomic nervous system: A consensus statement endorsed by the American Autonomic Society, American Academy of Neurology, and the International Federation of Clinical Neurophysiology.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Cheshire WP,
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Freeman R,
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Gibbons CH,
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Cortelli P,
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Wenning GK,
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Hilz MJ,
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Spies JM,
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Lipp A,
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Sandroni P,
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Wada N,
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Mano A,
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Kimpinski K,
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Iodice V,
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Idiáquez J,
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Thaisetthawatkul P,
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<span class="medgenPMjournal">Clin Neurophysiol</span>
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2021 Feb;132(2):666-682.
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Epub 2020 Dec 22
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doi: 10.1016/j.clinph.2020.11.024.
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<span class="bold">PMID: </span><a href="/pubmed/33419664" target="_blank">33419664</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/30788010">Cardiac Autonomic Neuropathy in Diabetes Mellitus.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Agashe S,
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<span class="medgenPMjournal">Methodist Debakey Cardiovasc J</span>
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2018 Oct-Dec;14(4):251-256.
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<span class="bold">PMID: </span><a href="/pubmed/30788010" target="_blank">30788010</a><a href="/pmc/articles/PMC6369622" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/28280231">2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Shen WK,
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Sheldon RS,
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Benditt DG,
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Cohen MI,
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Forman DE,
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Goldberger ZD,
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Grubb BP,
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Hamdan MH,
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Krahn AD,
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Link MS,
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Olshansky B,
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<span class="medgenPMjournal">Circulation</span>
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2017 Aug 1;136(5):e60-e122.
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<span class="bold">PMID: </span><a href="/pubmed/28280231" target="_blank">28280231</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/25686850">Syncope: diagnosis and management.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Walsh K,
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Hamdan MH</span><br />
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2015 Feb;40(2):51-86.
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Epub 2014 Nov 15
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<span class="bold">PMID: </span><a href="/pubmed/25686850" target="_blank">25686850</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/24262198">Autonomic disorders predicting Parkinson's disease.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Palma JA,
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2014 Jan;20 Suppl 1(0 1):S94-8.
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<span class="bold">PMID: </span><a href="/pubmed/24262198" target="_blank">24262198</a><a href="/pmc/articles/PMC4122262" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Orthostatic%20hypotension%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1654)</a></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">
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<div class="nl"><a target="_blank" href="/pubmed/37847274">Orthostatic Hypotension, Hypertension Treatment, and Cardiovascular Disease: An Individual Participant Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Juraschek SP,
|
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Hu JR,
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Cluett JL,
|
||
Ishak AM,
|
||
Mita C,
|
||
Lipsitz LA,
|
||
Appel LJ,
|
||
Beckett NS,
|
||
Coleman RL,
|
||
Cushman WC,
|
||
Davis BR,
|
||
Grandits G,
|
||
Holman RR,
|
||
Miller ER 3rd,
|
||
Peters R,
|
||
Staessen JA,
|
||
Taylor AA,
|
||
Thijs L,
|
||
Wright JT Jr,
|
||
Mukamal KJ</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2023 Oct 17;330(15):1459-1471.
|
||
doi: 10.1001/jama.2023.18497.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37847274" target="_blank">37847274</a><a href="/pmc/articles/PMC10582789" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34752479">Drug-induced orthostatic hypotension: A systematic review and meta-analysis of randomised controlled trials.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bhanu C,
|
||
Nimmons D,
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Petersen I,
|
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Orlu M,
|
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Davis D,
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Hussain H,
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||
Magammanage S,
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||
Walters K</span><br />
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<span class="medgenPMjournal">PLoS Med</span>
|
||
2021 Nov;18(11):e1003821.
|
||
Epub 2021 Nov 9
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||
doi: 10.1371/journal.pmed.1003821.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34752479" target="_blank">34752479</a><a href="/pmc/articles/PMC8577726" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32690803">Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yu JT,
|
||
Xu W,
|
||
Tan CC,
|
||
Andrieu S,
|
||
Suckling J,
|
||
Evangelou E,
|
||
Pan A,
|
||
Zhang C,
|
||
Jia J,
|
||
Feng L,
|
||
Kua EH,
|
||
Wang YJ,
|
||
Wang HF,
|
||
Tan MS,
|
||
Li JQ,
|
||
Hou XH,
|
||
Wan Y,
|
||
Tan L,
|
||
Mok V,
|
||
Tan L,
|
||
Dong Q,
|
||
Touchon J,
|
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Gauthier S,
|
||
Aisen PS,
|
||
Vellas B</span><br />
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||
<span class="medgenPMjournal">J Neurol Neurosurg Psychiatry</span>
|
||
2020 Nov;91(11):1201-1209.
|
||
Epub 2020 Jul 20
|
||
doi: 10.1136/jnnp-2019-321913.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32690803" target="_blank">32690803</a><a href="/pmc/articles/PMC7569385" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32450739">Blood Pressure and Risks of Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of 209 Prospective Studies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ou YN,
|
||
Tan CC,
|
||
Shen XN,
|
||
Xu W,
|
||
Hou XH,
|
||
Dong Q,
|
||
Tan L,
|
||
Yu JT</span><br />
|
||
<span class="medgenPMjournal">Hypertension</span>
|
||
2020 Jul;76(1):217-225.
|
||
Epub 2020 May 26
|
||
doi: 10.1161/HYPERTENSIONAHA.120.14993.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32450739" target="_blank">32450739</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30583909">Orthostatic Hypotension and Falls in Older Adults: A Systematic Review and Meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mol A,
|
||
Bui Hoang PTS,
|
||
Sharmin S,
|
||
Reijnierse EM,
|
||
van Wezel RJA,
|
||
Meskers CGM,
|
||
Maier AB</span><br />
|
||
<span class="medgenPMjournal">J Am Med Dir Assoc</span>
|
||
2019 May;20(5):589-597.e5.
|
||
Epub 2018 Dec 21
|
||
doi: 10.1016/j.jamda.2018.11.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30583909" target="_blank">30583909</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Orthostatic%20hypotension%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (104)</a></div></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22orthostatic%20hypotension%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Orthostatic%20hypotension%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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