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<meta name="keywords" content="C0008487, chdm, chordoma, chordoma (disease), chordoma, malignant, chordoma, susceptibility to, chordomas, neoplastic process, notochordal sarcoma, notochordoma, susceptibility to chordoma, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Chordomas are rare, clinically malignant tumors derived from notochordal remnants. They occur along the length of the spinal axis, predominantly in the sphenooccipital, vertebral, and sacrococcygeal regions. They are characterized by slow growth, local destruction of bone, extension into adjacent soft tissues, and, rarely, distant metastatic spread (Stepanek et al., 1998). The incidence of chordoma is age-dependent, with fewer than 5% occurring in children and adolescents (summary by McMaster et al., 2011)." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=40277
|
||
ConceptID=C0008487
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Chordoma</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>40277</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0008487</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Chordomas</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Chordoma (1156453008); Chordoma (50007008)</td></tr>
|
||
<tr><td>Modes of inheritance:</td>
|
||
<td>
|
||
<div class="divPopper rprt" id="moi_141047"><div><strong>Autosomal dominant inheritance</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>141047</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0443147</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Intellectual Product</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Source: Orphanet</div>
|
||
<div class="spaceAbove">A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.</div></div>
|
||
<div class="divPopper rprt" id="moi_988794"><div><strong>Not genetically inherited</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>988794</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms that cannot be identified in NLM's Unified Medical Language system (UMLS) Click for more information.">CN307044</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Source: Orphanet</div>
|
||
<div class="spaceAbove">clinical entity without genetic inheritance.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/988794">This record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_141047" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal dominant inheritance</a><span> (Orphanet)</span></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_988794" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Not genetically inherited</a><span> (Orphanet)</span></div></td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0010762">HP:0010762</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0008978" target="_blank">MONDO:0008978</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=178">ORPHA178</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_100">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Chordomas are rare, clinically malignant tumors derived from notochordal remnants. They occur along the length of the spinal axis, predominantly in the sphenooccipital, vertebral, and sacrococcygeal regions. They are characterized by slow growth, local destruction of bone, extension into adjacent soft tissues, and, rarely, distant metastatic spread (Stepanek et al., 1998). The incidence of chordoma is age-dependent, with fewer than 5% occurring in children and adolescents (summary by McMaster et al., 2011). [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_117">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Additional_description">Additional description</h1><a sid="117" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="mgSection"><strong>From MedlinePlus Genetics</strong><br />A chordoma is a rare type of cancerous tumor that can occur anywhere along the spine, from the base of the skull to the tailbone. Chordomas grow slowly, gradually extending into the bone and soft tissue around them. They often recur after treatment, and in about 40 percent of cases the cancer spreads (metastasizes) to other areas of the body, such as the lungs.<br /><br />Approximately half of all chordomas occur at the base of the spine (sacrum), about one third occur in the base of the skull (occiput), and the rest occur in the cervical (neck), thoracic (upper back), or lumbar (lower back) vertebrae of the spine. As the chordoma grows, it puts pressure on the adjacent areas of the brain or spinal cord, leading to the signs and symptoms of the disorder. A chordoma anywhere along the spine may cause pain, weakness, or numbness in the back, arms, or legs. A chordoma at the base of the skull (occipital chordoma) may lead to double vision (diplopia) and headaches. A chordoma that occurs in the tailbone (coccygeal chordoma) may result in a lump large enough to be felt through the skin and may cause problems with bladder or bowel function.<br /><br />Chordomas typically occur in adults between ages 40 and 70. About 5 percent of chordomas are diagnosed in children. For reasons that are unclear, males are affected about twice as often as females. <a target="_blank" href="https://medlineplus.gov/genetics/condition/chordoma">https://medlineplus.gov/genetics/condition/chordoma</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li><li><a href="#tabORDO">Orphanet</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Chordoma</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/272508" ref="tree=MeSH" title="MedGen record for Connective and Soft Tissue Disorder">Connective and Soft Tissue Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/1098" ref="tree=MeSH" title="MedGen record for Connective tissue disorder">Connective tissue disorder</a></span><ul><li><span class="TLline"><a href="/medgen/2701" ref="tree=MeSH" title="MedGen record for Bone Neoplasm">Bone Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/79002" ref="tree=MeSH" title="MedGen record for Bone cancer">Bone cancer</a></span><ul><li><span class="matched_ds">Chordoma</span><ul><li><span class="TLline"><a href="/medgen/1791577" ref="tree=MeSH" title="MedGen record for Conventional Chordoma">Conventional Chordoma</a></span><ul><li><span class="TLline"><a href="/medgen/224768" ref="tree=MeSH" title="MedGen record for Chondroid chordoma">Chondroid chordoma</a></span><ul><li><span class="TLline"><a href="/medgen/232373" ref="tree=MeSH" title="MedGen record for Clivus chondroid chordoma">Clivus chondroid chordoma</a></span></li><li><span class="TLline"><a href="/medgen/1669528" ref="tree=MeSH" title="MedGen record for Sellar Chondroid Chordoma">Sellar Chondroid Chordoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/220430" ref="tree=MeSH" title="MedGen record for Dedifferentiated Chordoma">Dedifferentiated Chordoma</a></span><ul><li><span class="TLline"><a href="/medgen/1695315" ref="tree=MeSH" title="MedGen record for Recurrent Dedifferentiated Chordoma">Recurrent Dedifferentiated Chordoma</a></span></li><li><span class="TLline"><a href="/medgen/1688814" ref="tree=MeSH" title="MedGen record for Refractory Dedifferentiated Chordoma">Refractory Dedifferentiated Chordoma</a></span></li><li><span class="TLline"><a href="/medgen/1661091" ref="tree=MeSH" title="MedGen record for Sellar Dedifferentiated Chordoma">Sellar Dedifferentiated Chordoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1653172" ref="tree=MeSH" title="MedGen record for Metastatic Chordoma">Metastatic Chordoma</a></span><ul><li><span class="TLline"><a href="/medgen/1766774" ref="tree=MeSH" title="MedGen record for Advanced Chordoma">Advanced Chordoma</a></span></li><li><span class="TLline"><a href="/medgen/1654752" ref="tree=MeSH" title="MedGen record for Locally Advanced Chordoma">Locally Advanced Chordoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1791171" ref="tree=MeSH" title="MedGen record for Poorly differentiated chordoma">Poorly differentiated chordoma</a></span></li><li><span class="TLline"><a href="/medgen/1670910" ref="tree=MeSH" title="MedGen record for Recurrent Chordoma">Recurrent Chordoma</a></span></li><li><span class="TLline"><a href="/medgen/1689454" ref="tree=MeSH" title="MedGen record for Refractory Chordoma">Refractory Chordoma</a></span></li><li><span class="TLline"><a href="/medgen/233448" ref="tree=MeSH" title="MedGen record for Skull base chordoma">Skull base chordoma</a></span><ul><li><span class="TLline"><a href="/medgen/232372" ref="tree=MeSH" title="MedGen record for Clivus chordoma">Clivus chordoma</a></span></li><li><span class="TLline"><a href="/medgen/1649471" ref="tree=MeSH" title="MedGen record for Sellar Chordoma">Sellar Chordoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/347800" ref="tree=MeSH" title="MedGen record for Spinal chordoma">Spinal chordoma</a></span><ul><li><span class="TLline"><a href="/medgen/1378104" ref="tree=MeSH" title="MedGen record for Sacral Chordoma">Sacral Chordoma</a></span></li><li><span class="TLline"><a href="/medgen/1791053" ref="tree=MeSH" title="MedGen record for Thoracic Chordoma">Thoracic Chordoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1664696" ref="tree=MeSH" title="MedGen record for Unresectable Chordoma">Unresectable Chordoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div><div id="tabORDO">Follow <a target="_blank" href="http://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&data_id=156&PatId=6023&search=Disease_Classif_Simple&new=1" class="ital bold">this link</a> to review classifications for <span class="ital">Chordoma</span> in Orphanet.</div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_344288"><div><strong>Tuberous sclerosis 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>344288</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1854465</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Tuberous sclerosis complex (TSC) involves abnormalities of the skin (hypomelanotic macules, confetti skin lesions, facial angiofibromas, shagreen patches, fibrous cephalic plaques, ungual fibromas); brain (subependymal nodules, cortical tubers, and subependymal giant cell astrocytomas [SEGAs], seizures, TSC-associated neuropsychiatric disorder [TAND]); kidneys (benign renal angiomyolipomas, epithelial cysts, oncocytoma, renal cell carcinoma); heart (rhabdomyomas, arrhythmias); and lungs (lymphangioleiomyomatosis [LAM], multifocal micronodular pneumonocyte hyperplasia). Central nervous system-related problems (including TAND) are the leading cause of morbidity, whereas kidney disease is the leading cause of mortality.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/344288">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_348170"><div><strong>Tuberous sclerosis 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>348170</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1860707</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Tuberous sclerosis complex (TSC) involves abnormalities of the skin (hypomelanotic macules, confetti skin lesions, facial angiofibromas, shagreen patches, fibrous cephalic plaques, ungual fibromas); brain (subependymal nodules, cortical tubers, and subependymal giant cell astrocytomas [SEGAs], seizures, TSC-associated neuropsychiatric disorder [TAND]); kidneys (benign renal angiomyolipomas, epithelial cysts, oncocytoma, renal cell carcinoma); heart (rhabdomyomas, arrhythmias); and lungs (lymphangioleiomyomatosis [LAM], multifocal micronodular pneumonocyte hyperplasia). Central nervous system-related problems (including TAND) are the leading cause of morbidity, whereas kidney disease is the leading cause of mortality.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/348170">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1787559"><div><strong>Chordoma, susceptibility to</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1787559</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5441694</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1787559">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1787559" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Chordoma, susceptibility to</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_344288" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Tuberous sclerosis 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_348170" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Tuberous sclerosis 2</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39368483">Clinical-proteomic classification and precision treatment strategy of chordoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yin H,
|
||
Hu J,
|
||
Gao J,
|
||
Su T,
|
||
Jin J,
|
||
Jiang C,
|
||
Yin W,
|
||
Xu X,
|
||
Chang Z,
|
||
Sun W,
|
||
Cai Z,
|
||
Zhou W,
|
||
Wang P,
|
||
Lin J,
|
||
Song D,
|
||
Meng T</span><br />
|
||
<span class="medgenPMjournal">Cell Rep Med</span>
|
||
2024 Oct 15;5(10):101757.
|
||
Epub 2024 Oct 4
|
||
doi: 10.1016/j.xcrm.2024.101757.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39368483" target="_blank">39368483</a><a href="/pmc/articles/PMC11513834" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26496212">Multidisciplinary approach of lumbo-sacral chordoma: From oncological treatment to reconstructive surgery.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Garofalo F,
|
||
di Summa PG,
|
||
Christoforidis D,
|
||
Pracht M,
|
||
Laudato P,
|
||
Cherix S,
|
||
Bouchaab H,
|
||
Raffoul W,
|
||
Demartines N,
|
||
Matter M</span><br />
|
||
<span class="medgenPMjournal">J Surg Oncol</span>
|
||
2015 Oct;112(5):544-54.
|
||
doi: 10.1002/jso.24026.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26496212" target="_blank">26496212</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15633956">Chordoma of the spine: clinicopathological features, diagnosis, and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Papagelopoulos PJ,
|
||
Mavrogenis AF,
|
||
Galanis EC,
|
||
Savvidou OD,
|
||
Boscainos PJ,
|
||
Katonis PG,
|
||
Sim FH</span><br />
|
||
<span class="medgenPMjournal">Orthopedics</span>
|
||
2004 Dec;27(12):1256-63; quiz 1264-5.
|
||
doi: 10.3928/0147-7447-20041201-14.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15633956" target="_blank">15633956</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22chordoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (180)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/bone.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bone Cancer, 2024</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33629710">INSM1 Expression in Chordomas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dridi M,
|
||
Boutonnat J,
|
||
Dumollard JM,
|
||
Peoc'h M,
|
||
Karpathiou G</span><br />
|
||
<span class="medgenPMjournal">Am J Clin Pathol</span>
|
||
2021 Aug 4;156(3):334-339.
|
||
doi: 10.1093/ajcp/aqaa250.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33629710" target="_blank">33629710</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33057707">Ependymoma and Chordoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Levine AB,
|
||
Wong D,
|
||
Fatehi M,
|
||
Yip S</span><br />
|
||
<span class="medgenPMjournal">Neurosurgery</span>
|
||
2020 Oct 15;87(5):860-870.
|
||
doi: 10.1093/neuros/nyaa329.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33057707" target="_blank">33057707</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32102007">Current opinion in otolaryngology and head and neck surgery: clival chordoma and its management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Snyderman CH,
|
||
Gardner PA</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Otolaryngol Head Neck Surg</span>
|
||
2020 Apr;28(2):118-121.
|
||
doi: 10.1097/MOO.0000000000000614.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32102007" target="_blank">32102007</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27475804">Immunotherapy as a Potential Treatment for Chordoma: a Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Patel SS,
|
||
Schwab JH</span><br />
|
||
<span class="medgenPMjournal">Curr Oncol Rep</span>
|
||
2016 Sep;18(9):55.
|
||
doi: 10.1007/s11912-016-0543-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27475804" target="_blank">27475804</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15641104">Skull base chordoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mendenhall WM,
|
||
Mendenhall CM,
|
||
Lewis SB,
|
||
Villaret DB,
|
||
Mendenhall NP</span><br />
|
||
<span class="medgenPMjournal">Head Neck</span>
|
||
2005 Feb;27(2):159-65.
|
||
doi: 10.1002/hed.20144.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15641104" target="_blank">15641104</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Chordoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1159)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34678279">Lung Chordoma: A Discussion.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kaufman D,
|
||
Farias V,
|
||
Lipton J,
|
||
Brichkov I</span><br />
|
||
<span class="medgenPMjournal">Ann Thorac Surg</span>
|
||
2022 Jul;114(1):e33-e34.
|
||
Epub 2021 Oct 19
|
||
doi: 10.1016/j.athoracsur.2021.09.018.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34678279" target="_blank">34678279</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34319396">Chordoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ulici V,
|
||
Hart J</span><br />
|
||
<span class="medgenPMjournal">Arch Pathol Lab Med</span>
|
||
2022 Mar 1;146(3):386-395.
|
||
doi: 10.5858/arpa.2020-0258-RA.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34319396" target="_blank">34319396</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34742484">Notochordal Tumors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tirabosco R,
|
||
O'Donnell P,
|
||
Flanagan AM</span><br />
|
||
<span class="medgenPMjournal">Surg Pathol Clin</span>
|
||
2021 Dec;14(4):619-643.
|
||
Epub 2021 Jul 28
|
||
doi: 10.1016/j.path.2021.06.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34742484" target="_blank">34742484</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16026431">Chordoma: radiological-pathological correlation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Maclean FM,
|
||
Soo MY,
|
||
Ng T</span><br />
|
||
<span class="medgenPMjournal">Australas Radiol</span>
|
||
2005 Aug;49(4):261-8.
|
||
doi: 10.1111/j.1440-1673.2005.01433.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16026431" target="_blank">16026431</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15641104">Skull base chordoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mendenhall WM,
|
||
Mendenhall CM,
|
||
Lewis SB,
|
||
Villaret DB,
|
||
Mendenhall NP</span><br />
|
||
<span class="medgenPMjournal">Head Neck</span>
|
||
2005 Feb;27(2):159-65.
|
||
doi: 10.1002/hed.20144.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15641104" target="_blank">15641104</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Chordoma%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1576)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/31067074">Proton therapy for brain tumours in the area of evidence-based medicine.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Weber DC,
|
||
Lim PS,
|
||
Tran S,
|
||
Walser M,
|
||
Bolsi A,
|
||
Kliebsch U,
|
||
Beer J,
|
||
Bachtiary B,
|
||
Lomax T,
|
||
Pica A</span><br />
|
||
<span class="medgenPMjournal">Br J Radiol</span>
|
||
2020 Mar;93(1107):20190237.
|
||
Epub 2019 May 20
|
||
doi: 10.1259/bjr.20190237.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31067074" target="_blank">31067074</a><a href="/pmc/articles/PMC7066950" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27760458">Chordomas and chondrosarcomas-The role of radiation therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">De Amorim Bernstein K,
|
||
DeLaney T</span><br />
|
||
<span class="medgenPMjournal">J Surg Oncol</span>
|
||
2016 Oct;114(5):564-569.
|
||
Epub 2016 Oct 19
|
||
doi: 10.1002/jso.24368.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27760458" target="_blank">27760458</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25415687">Proton therapy for sarcomas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Keole S,
|
||
Ashman JB,
|
||
Daniels TB</span><br />
|
||
<span class="medgenPMjournal">Cancer J</span>
|
||
2014 Nov-Dec;20(6):409-14.
|
||
doi: 10.1097/PPO.0000000000000084.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25415687" target="_blank">25415687</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21715048">Inadvertent insertion of nasogastric tube into the brain stem and spinal cord after endoscopic skull base surgery.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hanna AS,
|
||
Grindle CR,
|
||
Patel AA,
|
||
Rosen MR,
|
||
Evans JJ</span><br />
|
||
<span class="medgenPMjournal">Am J Otolaryngol</span>
|
||
2012 Jan-Feb;33(1):178-80.
|
||
Epub 2011 Jun 28
|
||
doi: 10.1016/j.amjoto.2011.04.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21715048" target="_blank">21715048</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21978899">Skull base chordomas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Koutourousiou M,
|
||
Snyderman CH,
|
||
Fernandez-Miranda J,
|
||
Gardner PA</span><br />
|
||
<span class="medgenPMjournal">Otolaryngol Clin North Am</span>
|
||
2011 Oct;44(5):1155-71.
|
||
Epub 2011 Jul 21
|
||
doi: 10.1016/j.otc.2011.06.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21978899" target="_blank">21978899</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Chordoma%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (509)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36089204">Chordoma: To know means to recognize.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Karele EN,
|
||
Paze AN</span><br />
|
||
<span class="medgenPMjournal">Biochim Biophys Acta Rev Cancer</span>
|
||
2022 Sep;1877(5):188796.
|
||
Epub 2022 Sep 9
|
||
doi: 10.1016/j.bbcan.2022.188796.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36089204" target="_blank">36089204</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29097372">Striking a chord.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gardner JA,
|
||
Devitt KA</span><br />
|
||
<span class="medgenPMjournal">Blood</span>
|
||
2017 Nov 2;130(18):2043.
|
||
doi: 10.1182/blood-2017-07-796904.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29097372" target="_blank">29097372</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21715048">Inadvertent insertion of nasogastric tube into the brain stem and spinal cord after endoscopic skull base surgery.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hanna AS,
|
||
Grindle CR,
|
||
Patel AA,
|
||
Rosen MR,
|
||
Evans JJ</span><br />
|
||
<span class="medgenPMjournal">Am J Otolaryngol</span>
|
||
2012 Jan-Feb;33(1):178-80.
|
||
Epub 2011 Jun 28
|
||
doi: 10.1016/j.amjoto.2011.04.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21715048" target="_blank">21715048</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15858504">Chordoma cutis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rubin AI,
|
||
Bagel J,
|
||
Niedt G</span><br />
|
||
<span class="medgenPMjournal">J Am Acad Dermatol</span>
|
||
2005 May;52(5 Suppl 1):S105-8.
|
||
doi: 10.1016/j.jaad.2004.07.055.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15858504" target="_blank">15858504</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15641104">Skull base chordoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mendenhall WM,
|
||
Mendenhall CM,
|
||
Lewis SB,
|
||
Villaret DB,
|
||
Mendenhall NP</span><br />
|
||
<span class="medgenPMjournal">Head Neck</span>
|
||
2005 Feb;27(2):159-65.
|
||
doi: 10.1002/hed.20144.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15641104" target="_blank">15641104</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Chordoma%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1104)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37772937">Integrating single-cell and spatial transcriptomics reveals endoplasmic reticulum stress-related CAF subpopulations associated with chordoma progression.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang TL,
|
||
Xia C,
|
||
Zheng BW,
|
||
Hu HH,
|
||
Jiang LX,
|
||
Escobar D,
|
||
Zheng BY,
|
||
Chen TD,
|
||
Li J,
|
||
Lv GH,
|
||
Huang W,
|
||
Yan YG,
|
||
Zou MX</span><br />
|
||
<span class="medgenPMjournal">Neuro Oncol</span>
|
||
2024 Feb 2;26(2):295-308.
|
||
doi: 10.1093/neuonc/noad173.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37772937" target="_blank">37772937</a><a href="/pmc/articles/PMC10836767" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37185233">Chordoma recruits and polarizes tumor-associated macrophages via secreting CCL5 to promote malignant progression.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Xu J,
|
||
Shi Q,
|
||
Lou J,
|
||
Wang B,
|
||
Wang W,
|
||
Niu J,
|
||
Guo L,
|
||
Chen C,
|
||
Yu Y,
|
||
Huang Y,
|
||
Guo W,
|
||
Lan J,
|
||
Zhu Y,
|
||
Ren T,
|
||
Tang X</span><br />
|
||
<span class="medgenPMjournal">J Immunother Cancer</span>
|
||
2023 Apr;11(4)
|
||
doi: 10.1136/jitc-2023-006808.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37185233" target="_blank">37185233</a><a href="/pmc/articles/PMC10151997" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25659512">Nonparaganglioma jugular foramen tumors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Thomas AJ,
|
||
Wiggins RH 3rd,
|
||
Gurgel RK</span><br />
|
||
<span class="medgenPMjournal">Otolaryngol Clin North Am</span>
|
||
2015 Apr;48(2):343-59.
|
||
Epub 2015 Feb 4
|
||
doi: 10.1016/j.otc.2014.12.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25659512" target="_blank">25659512</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25193090">Chordoma: the entity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yakkioui Y,
|
||
van Overbeeke JJ,
|
||
Santegoeds R,
|
||
van Engeland M,
|
||
Temel Y</span><br />
|
||
<span class="medgenPMjournal">Biochim Biophys Acta</span>
|
||
2014 Dec;1846(2):655-69.
|
||
Epub 2014 Sep 3
|
||
doi: 10.1016/j.bbcan.2014.07.012.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25193090" target="_blank">25193090</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8191635">Parachordoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Shin HJ,
|
||
Mackay B,
|
||
Ichinose H,
|
||
Ayala AG,
|
||
Romsdahl MM</span><br />
|
||
<span class="medgenPMjournal">Ultrastruct Pathol</span>
|
||
1994 Jan-Apr;18(1-2):249-56.
|
||
doi: 10.3109/01913129409016297.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8191635" target="_blank">8191635</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Chordoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (691)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/37705083">Efficacy and safety of carbon ion radiotherapy for chordomas: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dong M,
|
||
Liu R,
|
||
Zhang Q,
|
||
Wang D,
|
||
Luo H,
|
||
Wang Y,
|
||
Chen J,
|
||
Ou Y,
|
||
Wang X</span><br />
|
||
<span class="medgenPMjournal">Radiat Oncol</span>
|
||
2023 Sep 13;18(1):152.
|
||
doi: 10.1186/s13014-023-02337-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37705083" target="_blank">37705083</a><a href="/pmc/articles/PMC10500892" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34506978">Surgical Management of Spinal Chordoma: A Systematic Review and Single-Center Experience.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Baig Mirza A,
|
||
Bartram J,
|
||
Okasha M,
|
||
Al Banna Q,
|
||
Vastani A,
|
||
Maratos E,
|
||
Gullan R,
|
||
Thomas N</span><br />
|
||
<span class="medgenPMjournal">World Neurosurg</span>
|
||
2021 Dec;156:e111-e129.
|
||
Epub 2021 Sep 22
|
||
doi: 10.1016/j.wneu.2021.09.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34506978" target="_blank">34506978</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33932924">Systematic review of charged-particle therapy for chordomas and sarcomas of the mobile spine and sacrum.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pennington Z,
|
||
Ehresman J,
|
||
Elsamadicy AA,
|
||
Shin JH,
|
||
Goodwin CR,
|
||
Schwab JH,
|
||
Sciubba DM</span><br />
|
||
<span class="medgenPMjournal">Neurosurg Focus</span>
|
||
2021 May;50(5):E17.
|
||
doi: 10.3171/2021.2.FOCUS201059.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33932924" target="_blank">33932924</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30048230">Surgical management of chordoma: A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Denaro L,
|
||
Berton A,
|
||
Ciuffreda M,
|
||
Loppini M,
|
||
Candela V,
|
||
Brandi ML,
|
||
Longo UG</span><br />
|
||
<span class="medgenPMjournal">J Spinal Cord Med</span>
|
||
2020 Nov;43(6):797-812.
|
||
Epub 2018 Jul 26
|
||
doi: 10.1080/10790268.2018.1483593.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30048230" target="_blank">30048230</a><a href="/pmc/articles/PMC7808319" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29538244">Management of Sacrococcygeal Chordoma: A Systematic Review and Meta-analysis of Observational Studies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ahmed AT,
|
||
Abdel-Rahman O,
|
||
Morsy M,
|
||
Mustafa K,
|
||
Testini P,
|
||
Aleem IS,
|
||
Murad MH,
|
||
Nassr A</span><br />
|
||
<span class="medgenPMjournal">Spine (Phila Pa 1976)</span>
|
||
2018 Oct 1;43(19):E1157-E1169.
|
||
doi: 10.1097/BRS.0000000000002638.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29538244" target="_blank">29538244</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Chordoma%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (53)</a></div></div>
|
||
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|
||
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|
||
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|
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|
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<div class="supplemental col three_col last">
|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=178" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Chordoma" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22chordoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Chordoma%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nccn.org/professionals/physician_gls/pdf/bone.pdf">NCCN, 2024</a><div>NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bone Cancer, 2024</div></li></ul></div>
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