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1118 lines
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120 KiB
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<!--
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UID=39316
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ConceptID=C0085610
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Sinus bradycardia</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>39316</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0085610</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pathologic Function</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Sinus Bradycardia</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
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<td>Sinus bradycardia (49710005)</td></tr>
|
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<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0001688">HP:0001688</a></td></tr>
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||
<div class="portlet_content ln">Bradycardia related to a mean resting sinus rate of less than 50 beats per minute. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Sinus bradycardia</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/2848" ref="tree=MeSH" title="MedGen record for Disorder of cardiovascular system">Disorder of cardiovascular system</a></span><ul><li><span class="TLline"><a href="/medgen/116727" ref="tree=MeSH" title="MedGen record for Abnormality of the cardiovascular system">Abnormality of the cardiovascular system</a></span><ul><li><span class="TLline"><a href="/medgen/869166" ref="tree=MeSH" title="MedGen record for Abnormal cardiovascular system physiology">Abnormal cardiovascular system physiology</a></span><ul><li><span class="TLline"><a href="/medgen/1393551" ref="tree=MeSH" title="MedGen record for Abnormality of cardiovascular system electrophysiology">Abnormality of cardiovascular system electrophysiology</a></span><ul><li><span class="TLline"><a href="/medgen/2039" ref="tree=MeSH" title="MedGen record for Cardiac arrhythmia">Cardiac arrhythmia</a></span><ul><li><span class="TLline"><a href="/medgen/868812" ref="tree=MeSH" title="MedGen record for Abnormal electrophysiology of sinoatrial node origin">Abnormal electrophysiology of sinoatrial node origin</a></span><ul><li><span class="matched_ds">Sinus bradycardia</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_120524"><div><strong>Holt-Oram syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>120524</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0265264</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Holt-Oram syndrome (HOS) is characterized by upper-limb defects, congenital heart malformation, and cardiac conduction disease. Upper-limb malformations may be unilateral, bilateral/symmetric, or bilateral/asymmetric and can range from triphalangeal or absent thumb(s) to phocomelia. Other upper-limb malformations can include unequal arm length caused by aplasia or hypoplasia of the radius, fusion or anomalous development of the carpal and thenar bones, abnormal forearm pronation and supination, abnormal opposition of the thumb, sloping shoulders, and restriction of shoulder joint movement. An abnormal carpal bone is present in all affected individuals and may be the only evidence of disease. A congenital heart malformation is present in 75% of individuals with HOS and most commonly involves the septum. Atrial septal defect and ventricular septal defect can vary in number, size, and location. Complex congenital heart malformations can also occur in individuals with HOS. Individuals with HOS with or without a congenital heart malformation are at risk for cardiac conduction disease. While individuals may present at birth with sinus bradycardia and first-degree atrioventricular (AV) block, AV block can progress unpredictably to a higher grade including complete heart block with and without atrial fibrillation.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/120524">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_258500"><div><strong>Dilated cardiomyopathy 1A</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>258500</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1449563</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">LMNA-related dilated cardiomyopathy (DCM) is characterized by left ventricular enlargement and/or reduced systolic function preceded (sometimes by many years) by or accompanied by conduction system disease and/or arrhythmias. LMNA-related DCM usually presents in early to mid-adulthood with symptomatic conduction system disease or arrhythmias, or with symptomatic DCM including heart failure or embolus from a left ventricular mural thrombus. Sudden cardiac death can occur, and in some instances is the presenting manifestation; sudden cardiac death may occur with minimal or no systolic dysfunction.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/258500">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_316943"><div><strong>Dilated cardiomyopathy 1D</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>316943</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1832243</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Left ventricular noncompaction is a heart (cardiac) muscle disorder that occurs when the lower left chamber of the heart (left ventricle), which helps the heart pump blood, does not develop correctly. Instead of the muscle being smooth and firm, the cardiac muscle in the left ventricle is thick and appears spongy. The abnormal cardiac muscle is weak and has an impaired ability to pump blood because it either cannot completely contract or it cannot completely relax. For the heart to pump blood normally, cardiac muscle must contract and relax fully.\n\nSome individuals with left ventricular noncompaction experience no symptoms at all; others have heart problems that can include sudden cardiac death. Additional signs and symptoms include abnormal blood clots, irregular heart rhythm (arrhythmia), a sensation of fluttering or pounding in the chest (palpitations), extreme fatigue during exercise (exercise intolerance), shortness of breath (dyspnea), fainting (syncope), swelling of the legs (lymphedema), and trouble laying down flat. Some affected individuals have features of other heart defects. Left ventricular noncompaction can be diagnosed at any age, from birth to late adulthood. Approximately two-thirds of individuals with left ventricular noncompaction develop heart failure.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/316943">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_331395"><div><strong>Timothy syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>331395</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1832916</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The clinical manifestations of CACNA1C-related disorders include a spectrum of nonsyndromic and syndromic phenotypes, which generally correlate with the impact of the pathogenic variant on calcium current. Phenotypes can include nonsyndromic long QT syndrome (rate-corrected QT [QTc] interval >480 ms); nonsyndromic short QT syndrome (QTc <350 ms), with risk of sudden death; Brugada syndrome (ST segment elevation in right precordial leads [V1-V2]) with short QT interval; classic Timothy syndrome (prolonged QT interval, autism, and congenital heart defect) with or without unilateral or bilateral cutaneous syndactyly variably involving fingers two (index), three (middle), four (ring), and five (little) and bilateral cutaneous syndactyly of toes two and three; and CACNA1C-related neurodevelopmental disorder, in which the features tend to favor one or more of the following: developmental delay / intellectual disability, hypotonia, epilepsy, and/or ataxia.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/331395">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_331466"><div><strong>Hypertrophic cardiomyopathy 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>331466</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1833236</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Mutations in the PRKAG2 gene (602743) give rise to a moderate, essentially heart-specific, nonlysosomal glycogenosis with clinical onset typically in late adolescence or in the third decade of life, ventricular pre-excitation predisposing to supraventricular arrhythmias, mild to severe cardiac hypertrophy, enhanced risk of sudden cardiac death in midlife, and autosomal dominant inheritance with full penetrance (summary by Burwinkel et al., 2005).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/331466">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_320273"><div><strong>Sick sinus syndrome 2, autosomal dominant</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>320273</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1834144</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">Sick sinus syndrome (also known as sinus node dysfunction) is a group of related heart conditions that can affect how the heart beats. "Sick sinus" refers to the sino-atrial (SA) node, which is an area of specialized cells in the heart that functions as a natural pacemaker. The SA node generates electrical impulses that start each heartbeat. These signals travel from the SA node to the rest of the heart, signaling the heart (cardiac) muscle to contract and pump blood. In people with sick sinus syndrome, the SA node does not function normally. In some cases, it does not produce the right signals to trigger a regular heartbeat. In others, abnormalities disrupt the electrical impulses and prevent them from reaching the rest of the heart.\n\nSick sinus syndrome tends to cause the heartbeat to be too slow (bradycardia), although occasionally the heartbeat is too fast (tachycardia). In some cases, the heartbeat rapidly switches from being too fast to being too slow, a condition known as tachycardia-bradycardia syndrome. Symptoms related to abnormal heartbeats can include dizziness, light-headedness, fainting (syncope), a sensation of fluttering or pounding in the chest (palpitations), and confusion or memory problems. During exercise, many affected individuals experience chest pain, difficulty breathing, or excessive tiredness (fatigue). Once symptoms of sick sinus syndrome appear, they usually worsen with time. However, some people with the condition never experience any related health problems.\n\nSick sinus syndrome occurs most commonly in older adults, although it can be diagnosed in people of any age. The condition increases the risk of several life-threatening problems involving the heart and blood vessels. These include a heart rhythm abnormality called atrial fibrillation, heart failure, cardiac arrest, and stroke.</div>
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||
<div class="spaceAbove nowrap">See: <a href="/medgen/320273">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_325270"><div><strong>Sick sinus syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>325270</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1837845</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">The term 'sick sinus syndrome' encompasses a variety of conditions caused by sinus node dysfunction. The most common clinical manifestations are syncope, presyncope, dizziness, and fatigue. Electrocardiogram typically shows sinus bradycardia, sinus arrest, and/or sinoatrial block. Episodes of atrial tachycardias coexisting with sinus bradycardia ('tachycardia-bradycardia syndrome') are also common in this disorder. SSS occurs most often in the elderly associated with underlying heart disease or previous cardiac surgery, but can also occur in the fetus, infant, or child without heart disease or other contributing factors, in which case it is considered to be a congenital disorder (Benson et al., 2003). Genetic Heterogeneity of Sick Sinus Syndrome Sick sinus syndrome-2 (SSS2; 163800) is caused by mutation in the HCN4 gene (605206). Susceptibility to sick sinus syndrome-3 (SSS3; 614090) is influenced by variation in the MYH6 gene (160710). Sick sinus syndrome-4 (SSS4; 619464) is caused by mutation in the GNB2 gene (139390).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/325270">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_333884"><div><strong>Progressive familial heart block type II</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>333884</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1841658</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Progressive familial heart block type II (PFHB2) is an autosomal dominant disorder, similar to type I progressive familial heart block (PFHB1; see 113900). The pattern of PFHB2, however, tends to develop along the lines of a sinus bradycardia with a left posterior hemiblock, presenting clinically as syncopal episodes, Stokes-Adams seizures, or sudden death when complete heart block supervenes (Brink and Torrington, 1977).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/333884">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_342358"><div><strong>Pili torti-developmental delay-neurological abnormalities syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>342358</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1849811</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">Abnormal hair, joint laxity, and developmental delay (HJDD) is characterized by normal hair at birth that gradually becomes sparse, twisted, brittle, and easily broken, with pili torti and trichorrhexis nodosa observed on light microscopy. Other features include increased joint mobility and cognitive delay (summary by Sharma et al., 2019).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/342358">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_338862"><div><strong>Distichiasis with congenital anomalies of the heart and peripheral vasculature</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>338862</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1852062</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/338862">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_358092"><div><strong>Long QT syndrome 5</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>358092</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1867904</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">Congenital long QT syndrome is electrocardiographically characterized by a prolonged QT interval and polymorphic ventricular arrhythmias (torsade de pointes). These cardiac arrhythmias may result in recurrent syncope, seizure, or sudden death (Jongbloed et al., 1999). For a discussion of genetic heterogeneity of long QT syndrome, see LQT1 (192500).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/358092">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_370181"><div><strong>Cardiac arrhythmia, ankyrin-B-related</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>370181</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1970119</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">Loss-of-function mutations in ANK2 can result in a broad spectrum of clinical cardiac phenotypes. Carriers of some mutations (e.g., E1425G, 106410.0001) display QT interval prolongation, stress- and/or exercise-induced polymorphic ventricular arrhythmia, syncope, and sudden cardiac death. Patients with other variants show clinical phenotypes, sometimes mild, extending beyond LQTS, leading to the label 'ankyrin-B syndrome.' These phenotypes include bradycardia, sinus arrhythmia, delayed conduction/conduction block, idiopathic ventricular fibrillation, and catecholaminergic polymorphic ventricular tachycardia (Mohler et al., 2007).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/370181">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_393658"><div><strong>Atrial fibrillation, familial, 7</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>393658</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2677106</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">Atrial fibrillation (AF) is the most common sustained cardiac rhythm disturbance, affecting more than 2 million Americans, with an overall prevalence of 0.89%. The prevalence increases rapidly with age, to 2.3% between the ages of 40 and 60 years, and to 5.9% over the age of 65. The most dreaded complication is thromboembolic stroke (Brugada et al., 1997). For a discussion of genetic heterogeneity of atrial fibrillation, see 608583.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/393658">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_395635"><div><strong>Long QT syndrome 9</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>395635</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2678485</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Congenital long QT syndrome is electrocardiographically characterized by a prolonged QT interval and polymorphic ventricular arrhythmias (torsade de pointes). These cardiac arrhythmias may result in recurrent syncope, seizure, or sudden death (Jongbloed et al., 1999). For a discussion of genetic heterogeneity of long QT syndrome, see LQT1 (192500).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/395635">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_863722"><div><strong>Atrial conduction disease</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>863722</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4015285</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A rare genetic cardiac disease characterized by variably expressed atrial tachyarrhythmia (such as atrial flutter, paroxysmal or chronic atrial fibrillation, ectopic atrial tachycardia, or multifocal atrial tachycardia), infra-Hisian conduction system disease, and vulnerability to dilated cardiomyopathy. Age of onset ranges between childhood and adulthood.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/863722">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_864132"><div><strong>Long QT syndrome 15</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>864132</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4015695</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">LQT15 is a cardiac arrhythmia disorder characterized by ventricular arrhythmias, often life-threatening, occurring very early in life, frequent episodes of T-wave alternans, markedly prolonged QTc intervals, and intermittent 2:1 atrioventricular block (Crotti et al., 2013). Patients with LQT14 (616247), LQT15, or LQT16 (618782), resulting from mutation in calmodulin genes CALM1 (114180), CALM2, or CALM3 (114183), respectively, typically have a more severe phenotype, with earlier onset, profound QT prolongation, and a high predilection for cardiac arrest and sudden death, than patients with mutations in other genes (Boczek et al., 2016).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/864132">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1683958"><div><strong>Combined oxidative phosphorylation deficiency 39</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1683958</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5193075</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Combined oxidative phosphorylation deficiency-39 (COXPD39) is an autosomal recessive multisystem disorder resulting from a defect in mitochondrial energy metabolism. Affected individuals show global developmental delay, sometimes with regression after normal early development, axial hypotonia with limb spasticity or abnormal involuntary movements, and impaired intellectual development with poor speech. More variable features may include hypotonia, seizures, and features of Leigh syndrome (256000) on brain imaging. There are variable deficiencies of the mitochondrial respiratory chain enzyme complexes in patient tissues (summary by Glasgow et al., 2017). For a discussion of genetic heterogeneity of combined oxidative phosphorylation deficiency, see COXPD1 (609060).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1683958">Condition Record</a></div></div>
|
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<div class="divPopper rprt" id="rdis_1794159"><div><strong>Sick sinus syndrome 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1794159</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5561949</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">Sick sinus syndrome-4 (SSS4) is characterized by early and progressive sinus node and atrioventricular conduction dysfunction. Patients show bradycardia and chronotropic incompetence, and may experience syncope. Atrioventricular conduction block ranges from mild to severe, and some patients also have intermittent atrial fibrillation. Many require implantation of a pacemaker, but sudden cardiac death has not been reported (Stallmeyer et al., 2017). For a general phenotypic description and discussion of genetic heterogeneity of sick sinus syndrome, see SSS1 (608567).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1794159">Condition Record</a></div></div>
|
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<div class="divPopper rprt" id="rdis_1794173"><div><strong>Central hypoventilation syndrome, congenital, 2, and autonomic dysfunction</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1794173</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5561963</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Congenital central hypoventilation syndrome-2 and autonomic dysfunction (CCHS2) is an autosomal recessive disorder characterized by shallow breathing and apneic spells apparent in the neonatal period. Affected infants require mechanical ventilation due to impaired ventilatory response to hypercapnia, as well as tube feeding due to poor swallowing, aspiration, and gastrointestinal dysmotility. Some patients have other features of autonomic dysfunction, including bladder dysfunction, sinus bradycardia, and temperature dysregulation. Although mild global developmental delay with learning difficulties and seizures were present in the single family reported, it was unclear if these features were related to the hypoventilation phenotype (Spielmann et al., 2017). For a discussion of genetic heterogeneity of CCHS, see CCHS1 (209880).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/1794173">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_1799561"><div><strong>Autosomal recessive limb-girdle muscular dystrophy type 2X</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1799561</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5568138</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Autosomal recessive limb-girdle muscular dystrophy-25 (LGMDR25) is characterized by slowly progressive onset of proximal lower limb weakness in adulthood. Affected individuals also develop cardiac arrhythmias resulting in syncopal episodes as young adults or later in life (summary by Schindler et al., 2016). For a discussion of genetic heterogeneity of autosomal recessive limb-girdle muscular dystrophy (LGMD), see LGMDR1 (253600).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/1799561">Condition Record</a></div></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_863722" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Atrial conduction disease</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_393658" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Atrial fibrillation, familial, 7</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1799561" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal recessive limb-girdle muscular dystrophy type 2X</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_370181" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cardiac arrhythmia, ankyrin-B-related</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1794173" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Central hypoventilation syndrome, congenital, 2, and autonomic dysfunction</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (20)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1683958" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Combined oxidative phosphorylation deficiency 39</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_258500" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dilated cardiomyopathy 1A</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_316943" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dilated cardiomyopathy 1D</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_338862" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Distichiasis with congenital anomalies of the heart and peripheral vasculature</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_120524" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Holt-Oram syndrome</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_331466" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypertrophic cardiomyopathy 6</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_864132" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Long QT syndrome 15</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_358092" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Long QT syndrome 5</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_395635" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Long QT syndrome 9</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_342358" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pili torti-developmental delay-neurological abnormalities syndrome</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_333884" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Progressive familial heart block type II</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_325270" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Sick sinus syndrome 1</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_320273" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Sick sinus syndrome 2, autosomal dominant</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1794159" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Sick sinus syndrome 4</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_331395" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Timothy syndrome</a></div></span></div></div>
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</div>
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<div class="portlet mgSection" id="ID_105">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
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<div class="nl"><a target="_blank" href="/pubmed/30586772">2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Kusumoto FM,
|
||
Schoenfeld MH,
|
||
Barrett C,
|
||
Edgerton JR,
|
||
Ellenbogen KA,
|
||
Gold MR,
|
||
Goldschlager NF,
|
||
Hamilton RM,
|
||
Joglar JA,
|
||
Kim RJ,
|
||
Lee R,
|
||
Marine JE,
|
||
McLeod CJ,
|
||
Oken KR,
|
||
Patton KK,
|
||
Pellegrini CN,
|
||
Selzman KA,
|
||
Thompson A,
|
||
Varosy PD</span><br />
|
||
<span class="medgenPMjournal">Circulation</span>
|
||
2019 Aug 20;140(8):e382-e482.
|
||
Epub 2018 Nov 6
|
||
doi: 10.1161/CIR.0000000000000628.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30586772" target="_blank">30586772</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30412709">2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kusumoto FM,
|
||
Schoenfeld MH,
|
||
Barrett C,
|
||
Edgerton JR,
|
||
Ellenbogen KA,
|
||
Gold MR,
|
||
Goldschlager NF,
|
||
Hamilton RM,
|
||
Joglar JA,
|
||
Kim RJ,
|
||
Lee R,
|
||
Marine JE,
|
||
McLeod CJ,
|
||
Oken KR,
|
||
Patton KK,
|
||
Pellegrini CN,
|
||
Selzman KA,
|
||
Thompson A,
|
||
Varosy PD</span><br />
|
||
<span class="medgenPMjournal">J Am Coll Cardiol</span>
|
||
2019 Aug 20;74(7):e51-e156.
|
||
Epub 2018 Nov 6
|
||
doi: 10.1016/j.jacc.2018.10.044.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30412709" target="_blank">30412709</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26780751">Evaluation and management of bradycardia in neonates and children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Baruteau AE,
|
||
Perry JC,
|
||
Sanatani S,
|
||
Horie M,
|
||
Dubin AM</span><br />
|
||
<span class="medgenPMjournal">Eur J Pediatr</span>
|
||
2016 Feb;175(2):151-61.
|
||
Epub 2016 Jan 16
|
||
doi: 10.1007/s00431-015-2689-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26780751" target="_blank">26780751</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22sinus%20bradycardia%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (65)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/30738635">Fetal dysrhythmias.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Carvalho JS</span><br />
|
||
<span class="medgenPMjournal">Best Pract Res Clin Obstet Gynaecol</span>
|
||
2019 Jul;58:28-41.
|
||
Epub 2019 Jan 9
|
||
doi: 10.1016/j.bpobgyn.2019.01.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30738635" target="_blank">30738635</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27830772">Diagnosis, pathophysiology, and management of exercise-induced arrhythmias.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Guasch E,
|
||
Mont L</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Cardiol</span>
|
||
2017 Feb;14(2):88-101.
|
||
Epub 2016 Nov 10
|
||
doi: 10.1038/nrcardio.2016.173.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27830772" target="_blank">27830772</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26780751">Evaluation and management of bradycardia in neonates and children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Baruteau AE,
|
||
Perry JC,
|
||
Sanatani S,
|
||
Horie M,
|
||
Dubin AM</span><br />
|
||
<span class="medgenPMjournal">Eur J Pediatr</span>
|
||
2016 Feb;175(2):151-61.
|
||
Epub 2016 Jan 16
|
||
doi: 10.1007/s00431-015-2689-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26780751" target="_blank">26780751</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26710932">Cardiovascular complications of anorexia nervosa: A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sachs KV,
|
||
Harnke B,
|
||
Mehler PS,
|
||
Krantz MJ</span><br />
|
||
<span class="medgenPMjournal">Int J Eat Disord</span>
|
||
2016 Mar;49(3):238-48.
|
||
Epub 2015 Dec 29
|
||
doi: 10.1002/eat.22481.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26710932" target="_blank">26710932</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18376273">Glucocorticoid-associated Bradycardia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">van der Gugten A,
|
||
Bierings M,
|
||
Frenkel J</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Hematol Oncol</span>
|
||
2008 Feb;30(2):172-5.
|
||
doi: 10.1097/MPH.0b013e31815dcfeb.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18376273" target="_blank">18376273</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Sinus%20bradycardia%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (596)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34383451">Sinus Node Dysfunction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hawks MK,
|
||
Paul MLB,
|
||
Malu OO</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2021 Aug 1;104(2):179-185.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34383451" target="_blank">34383451</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30586772">2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kusumoto FM,
|
||
Schoenfeld MH,
|
||
Barrett C,
|
||
Edgerton JR,
|
||
Ellenbogen KA,
|
||
Gold MR,
|
||
Goldschlager NF,
|
||
Hamilton RM,
|
||
Joglar JA,
|
||
Kim RJ,
|
||
Lee R,
|
||
Marine JE,
|
||
McLeod CJ,
|
||
Oken KR,
|
||
Patton KK,
|
||
Pellegrini CN,
|
||
Selzman KA,
|
||
Thompson A,
|
||
Varosy PD</span><br />
|
||
<span class="medgenPMjournal">Circulation</span>
|
||
2019 Aug 20;140(8):e382-e482.
|
||
Epub 2018 Nov 6
|
||
doi: 10.1161/CIR.0000000000000628.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30586772" target="_blank">30586772</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30412709">2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kusumoto FM,
|
||
Schoenfeld MH,
|
||
Barrett C,
|
||
Edgerton JR,
|
||
Ellenbogen KA,
|
||
Gold MR,
|
||
Goldschlager NF,
|
||
Hamilton RM,
|
||
Joglar JA,
|
||
Kim RJ,
|
||
Lee R,
|
||
Marine JE,
|
||
McLeod CJ,
|
||
Oken KR,
|
||
Patton KK,
|
||
Pellegrini CN,
|
||
Selzman KA,
|
||
Thompson A,
|
||
Varosy PD</span><br />
|
||
<span class="medgenPMjournal">J Am Coll Cardiol</span>
|
||
2019 Aug 20;74(7):e51-e156.
|
||
Epub 2018 Nov 6
|
||
doi: 10.1016/j.jacc.2018.10.044.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30412709" target="_blank">30412709</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26780751">Evaluation and management of bradycardia in neonates and children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Baruteau AE,
|
||
Perry JC,
|
||
Sanatani S,
|
||
Horie M,
|
||
Dubin AM</span><br />
|
||
<span class="medgenPMjournal">Eur J Pediatr</span>
|
||
2016 Feb;175(2):151-61.
|
||
Epub 2016 Jan 16
|
||
doi: 10.1007/s00431-015-2689-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26780751" target="_blank">26780751</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16487786">Pediatric dysrhythmias.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Doniger SJ,
|
||
Sharieff GQ</span><br />
|
||
<span class="medgenPMjournal">Pediatr Clin North Am</span>
|
||
2006 Feb;53(1):85-105, vi.
|
||
doi: 10.1016/j.pcl.2005.10.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16487786" target="_blank">16487786</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Sinus%20bradycardia%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (649)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/30412778">2018 ACC/AHA/HRS guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Writing Committee Members,
|
||
Kusumoto FM,
|
||
Schoenfeld MH,
|
||
Barrett C,
|
||
Edgerton JR,
|
||
Ellenbogen KA,
|
||
Gold MR,
|
||
Goldschlager NF,
|
||
Hamilton RM,
|
||
Joglar JA,
|
||
Kim RJ,
|
||
Lee R,
|
||
Marine JE,
|
||
McLeod CJ,
|
||
Oken KR,
|
||
Patton KK,
|
||
Pellegrini CN,
|
||
Selzman KA,
|
||
Thompson A,
|
||
Varosy PD</span><br />
|
||
<span class="medgenPMjournal">Heart Rhythm</span>
|
||
2019 Sep;16(9):e128-e226.
|
||
Epub 2018 Nov 6
|
||
doi: 10.1016/j.hrthm.2018.10.037.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30412778" target="_blank">30412778</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29289259">Cannabinoids and Symptomatic Bradycardia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Heckle MR,
|
||
Nayyar M,
|
||
Sinclair SE,
|
||
Weber KT</span><br />
|
||
<span class="medgenPMjournal">Am J Med Sci</span>
|
||
2018 Jan;355(1):3-5.
|
||
Epub 2017 Mar 22
|
||
doi: 10.1016/j.amjms.2017.03.027.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29289259" target="_blank">29289259</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23440789">Cooling for newborns with hypoxic ischaemic encephalopathy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jacobs SE,
|
||
Berg M,
|
||
Hunt R,
|
||
Tarnow-Mordi WO,
|
||
Inder TE,
|
||
Davis PG</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2013 Jan 31;2013(1):CD003311.
|
||
doi: 10.1002/14651858.CD003311.pub3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23440789" target="_blank">23440789</a><a href="/pmc/articles/PMC7003568" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16487786">Pediatric dysrhythmias.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Doniger SJ,
|
||
Sharieff GQ</span><br />
|
||
<span class="medgenPMjournal">Pediatr Clin North Am</span>
|
||
2006 Feb;53(1):85-105, vi.
|
||
doi: 10.1016/j.pcl.2005.10.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16487786" target="_blank">16487786</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15961013">Methadone-induced bradycardia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ashwath ML,
|
||
Ajjan M,
|
||
Culclasure T</span><br />
|
||
<span class="medgenPMjournal">J Emerg Med</span>
|
||
2005 Jul;29(1):73-5.
|
||
doi: 10.1016/j.jemermed.2004.10.022.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15961013" target="_blank">15961013</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Sinus%20bradycardia%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (662)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34992725">Arrhythmias in COVID-19.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pandat S,
|
||
Zhu Z,
|
||
Fuentes-Rojas S,
|
||
Schurmann P</span><br />
|
||
<span class="medgenPMjournal">Methodist Debakey Cardiovasc J</span>
|
||
2021;17(5):73-82.
|
||
Epub 2021 Dec 15
|
||
doi: 10.14797/mdcvj.1039.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34992725" target="_blank">34992725</a><a href="/pmc/articles/PMC8679991" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34383451">Sinus Node Dysfunction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hawks MK,
|
||
Paul MLB,
|
||
Malu OO</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2021 Aug 1;104(2):179-185.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34383451" target="_blank">34383451</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31151977">Junctional bradycardia caused by ciguatera intoxication.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Raman R,
|
||
Coppes S,
|
||
Hellingman T,
|
||
Laclé C</span><br />
|
||
<span class="medgenPMjournal">BMJ Case Rep</span>
|
||
2019 May 30;12(5)
|
||
doi: 10.1136/bcr-2019-229354.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31151977" target="_blank">31151977</a><a href="/pmc/articles/PMC6557356" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30738635">Fetal dysrhythmias.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Carvalho JS</span><br />
|
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<span class="medgenPMjournal">Best Pract Res Clin Obstet Gynaecol</span>
|
||
2019 Jul;58:28-41.
|
||
Epub 2019 Jan 9
|
||
doi: 10.1016/j.bpobgyn.2019.01.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30738635" target="_blank">30738635</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26780751">Evaluation and management of bradycardia in neonates and children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Baruteau AE,
|
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Perry JC,
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Sanatani S,
|
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Horie M,
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Dubin AM</span><br />
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<span class="medgenPMjournal">Eur J Pediatr</span>
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2016 Feb;175(2):151-61.
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Epub 2016 Jan 16
|
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doi: 10.1007/s00431-015-2689-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26780751" target="_blank">26780751</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Sinus%20bradycardia%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (381)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34992725">Arrhythmias in COVID-19.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pandat S,
|
||
Zhu Z,
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Fuentes-Rojas S,
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Schurmann P</span><br />
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<span class="medgenPMjournal">Methodist Debakey Cardiovasc J</span>
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2021;17(5):73-82.
|
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Epub 2021 Dec 15
|
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doi: 10.14797/mdcvj.1039.
|
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<span class="bold">PMID: </span><a href="/pubmed/34992725" target="_blank">34992725</a><a href="/pmc/articles/PMC8679991" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34383451">Sinus Node Dysfunction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hawks MK,
|
||
Paul MLB,
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||
Malu OO</span><br />
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||
<span class="medgenPMjournal">Am Fam Physician</span>
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2021 Aug 1;104(2):179-185.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34383451" target="_blank">34383451</a></div>
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||
<div class="nl"><a target="_blank" href="/pubmed/30640577">Asymptomatic bradycardia amongst endurance athletes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Doyen B,
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Matelot D,
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Carré F</span><br />
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<span class="medgenPMjournal">Phys Sportsmed</span>
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2019 Sep;47(3):249-252.
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Epub 2019 Jan 21
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doi: 10.1080/00913847.2019.1568769.
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||
<span class="bold">PMID: </span><a href="/pubmed/30640577" target="_blank">30640577</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26780751">Evaluation and management of bradycardia in neonates and children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Baruteau AE,
|
||
Perry JC,
|
||
Sanatani S,
|
||
Horie M,
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||
Dubin AM</span><br />
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||
<span class="medgenPMjournal">Eur J Pediatr</span>
|
||
2016 Feb;175(2):151-61.
|
||
Epub 2016 Jan 16
|
||
doi: 10.1007/s00431-015-2689-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26780751" target="_blank">26780751</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18376273">Glucocorticoid-associated Bradycardia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">van der Gugten A,
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Bierings M,
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Frenkel J</span><br />
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<span class="medgenPMjournal">J Pediatr Hematol Oncol</span>
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2008 Feb;30(2):172-5.
|
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doi: 10.1097/MPH.0b013e31815dcfeb.
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||
<span class="bold">PMID: </span><a href="/pubmed/18376273" target="_blank">18376273</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Sinus%20bradycardia%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (455)</a></div></div>
|
||
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|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln">
|
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<div class="nl"><a target="_blank" href="/pubmed/35612830">Cardiovascular sequelae of dengue fever: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rahim A,
|
||
Hameed A,
|
||
Ishaq U,
|
||
Malik J,
|
||
Zaidi SMJ,
|
||
Khurshid H,
|
||
Malik A,
|
||
Satti DI,
|
||
Naz H</span><br />
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||
<span class="medgenPMjournal">Expert Rev Cardiovasc Ther</span>
|
||
2022 Jun;20(6):465-479.
|
||
Epub 2022 Jun 2
|
||
doi: 10.1080/14779072.2022.2082945.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35612830" target="_blank">35612830</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34971926">Prevalence, types and treatment of bradycardia in obstructive sleep apnea - A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Teo YH,
|
||
Han R,
|
||
Leong S,
|
||
Teo YN,
|
||
Syn NL,
|
||
Wee CF,
|
||
Tan BKJ,
|
||
Wong RC,
|
||
Chai P,
|
||
Kojodjojo P,
|
||
Kong WK,
|
||
Lee CH,
|
||
Sia CH,
|
||
Yeo TC</span><br />
|
||
<span class="medgenPMjournal">Sleep Med</span>
|
||
2022 Jan;89:104-113.
|
||
Epub 2021 Dec 10
|
||
doi: 10.1016/j.sleep.2021.12.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34971926" target="_blank">34971926</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31660784">Sinus Bradycardia During Targeted Temperature Management: A Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kyriazopoulou E,
|
||
Karakike E,
|
||
Ekmektzoglou K,
|
||
Kyprianou M,
|
||
Gkolfakis P,
|
||
Chalkias A,
|
||
Kouskouni E,
|
||
Xanthos T</span><br />
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||
<span class="medgenPMjournal">Ther Hypothermia Temp Manag</span>
|
||
2020 Mar;10(1):17-26.
|
||
Epub 2019 Oct 29
|
||
doi: 10.1089/ther.2019.0027.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31660784" target="_blank">31660784</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26710932">Cardiovascular complications of anorexia nervosa: A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sachs KV,
|
||
Harnke B,
|
||
Mehler PS,
|
||
Krantz MJ</span><br />
|
||
<span class="medgenPMjournal">Int J Eat Disord</span>
|
||
2016 Mar;49(3):238-48.
|
||
Epub 2015 Dec 29
|
||
doi: 10.1002/eat.22481.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26710932" target="_blank">26710932</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23440789">Cooling for newborns with hypoxic ischaemic encephalopathy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jacobs SE,
|
||
Berg M,
|
||
Hunt R,
|
||
Tarnow-Mordi WO,
|
||
Inder TE,
|
||
Davis PG</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2013 Jan 31;2013(1):CD003311.
|
||
doi: 10.1002/14651858.CD003311.pub3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23440789" target="_blank">23440789</a><a href="/pmc/articles/PMC7003568" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Sinus%20bradycardia%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (16)</a></div></div>
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22sinus%20bradycardia%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Sinus%20bradycardia%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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