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<meta name="keywords" content="C1857045, abnormal philtrum, abnormality of the infranasal depression, abnormality of the paralabial region, abnormality of the philtrum, finding, philtrum abnormalities, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="An abnormality of the philtrum." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=384043
|
||
ConceptID=C1857045
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Abnormality of the philtrum</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>384043</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1857045</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Abnormal philtrum; Philtrum abnormalities</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0000288">HP:0000288</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">An abnormality of the philtrum. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1857045[DISCUI]&test_type=Clinical" ref="ncbi_uid=384043">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Abnormality of the philtrum</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/871375" ref="tree=MeSH" title="MedGen record for Abnormality of the face">Abnormality of the face</a></span><ul><li><span class="TLline"><a href="/medgen/6447" ref="tree=MeSH" title="MedGen record for Abnormality of the mouth">Abnormality of the mouth</a></span><ul><li><span class="TLline"><a href="/medgen/1645271" ref="tree=MeSH" title="MedGen record for Abnormal oral morphology">Abnormal oral morphology</a></span><ul><li><span class="TLline"><a href="/medgen/871391" ref="tree=MeSH" title="MedGen record for Abnormal oral cavity morphology">Abnormal oral cavity morphology</a></span><ul><li><span class="TLline"><a href="/medgen/389175" ref="tree=MeSH" title="MedGen record for Abnormal lip morphology">Abnormal lip morphology</a></span><ul><li><span class="TLline"><a href="/medgen/871388" ref="tree=MeSH" title="MedGen record for Abnormal upper lip morphology">Abnormal upper lip morphology</a></span><ul><li><span class="matched_ds">Abnormality of the philtrum</span><ul><li><span class="TLline"><a href="/medgen/344210" ref="tree=MeSH" title="MedGen record for Broad philtrum">Broad philtrum</a></span></li><li><span class="TLline"><a href="/medgen/374311" ref="tree=MeSH" title="MedGen record for Deep philtrum">Deep philtrum</a></span></li><li><span class="TLline"><a href="/medgen/341641" ref="tree=MeSH" title="MedGen record for Hypoplastic philtrum">Hypoplastic philtrum</a></span></li><li><span class="TLline"><a href="/medgen/351278" ref="tree=MeSH" title="MedGen record for Long philtrum">Long philtrum</a></span></li><li><span class="TLline"><a href="/medgen/866766" ref="tree=MeSH" title="MedGen record for Malaligned philtral ridges">Malaligned philtral ridges</a></span></li><li><span class="TLline"><a href="/medgen/866765" ref="tree=MeSH" title="MedGen record for Midline sinus of philtrum">Midline sinus of philtrum</a></span></li><li><span class="TLline"><a href="/medgen/866764" ref="tree=MeSH" title="MedGen record for Narrow philtrum">Narrow philtrum</a></span></li><li><span class="TLline"><a href="/medgen/866767" ref="tree=MeSH" title="MedGen record for Philtrum with midline raphe">Philtrum with midline raphe</a></span></li><li><span class="TLline"><a href="/medgen/350006" ref="tree=MeSH" title="MedGen record for Short philtrum">Short philtrum</a></span></li><li><span class="TLline"><a href="/medgen/222980" ref="tree=MeSH" title="MedGen record for Smooth philtrum">Smooth philtrum</a></span></li><li><span class="TLline"><a href="/medgen/866768" ref="tree=MeSH" title="MedGen record for Tented philtrum">Tented philtrum</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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</div>
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<div class="portlet mgSection" id="ID_112">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_444067"><div><strong>Cleft lip/palate-ectodermal dysplasia syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>444067</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2931488</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Zlotogora-Ogur syndrome is an ectodermal dysplasia syndrome with characteristics of hair, skin and teeth anomalies, facial dysmorphism with cleft lip and palate, cutaneous syndactyly and, in some cases, intellectual disability.The prevalence is unknown but to date, less than 50 cases have been described in the literature. Caused by mutations in the gene PVRL1 (11q23-q24) which encodes nectin-1, the principal receptor used by alpha-herpesviruses to mediate entry into human cells. Transmission is autosomal recessive.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/444067">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_477139"><div><strong>Multiple congenital anomalies-hypotonia-seizures syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>477139</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3275508</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Multiple congenital anomalies-hypotonia-seizures syndrome-2 (MCAHS2) is an X-linked recessive neurodevelopmental disorder characterized by dysmorphic features, neonatal hypotonia, early-onset myoclonic seizures, and variable congenital anomalies involving the central nervous, cardiac, and urinary systems. Some affected individuals die in infancy (summary by Johnston et al., 2012). The phenotype shows clinical variability with regard to severity and extraneurologic features. However, most patients present in infancy with early-onset epileptic encephalopathy associated with developmental arrest and subsequent severe neurologic disability; these features are consistent with a form of developmental and epileptic encephalopathy (DEE) (summary by Belet et al., 2014, Kato et al., 2014). The disorder is caused by a defect in glycosylphosphatidylinositol (GPI) biosynthesis. For a discussion of genetic heterogeneity of MCAHS, see MCAHS1 (614080). For a discussion of nomenclature and genetic heterogeneity of DEE, see 308350. For a discussion of genetic heterogeneity of GPI biosynthesis defects, see GPIBD1 (610293).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/477139">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1807366"><div><strong>Schaaf-Yang syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1807366</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5575066</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Schaaf-Yang syndrome (SYS) is a rare neurodevelopmental disorder that shares multiple clinical features with the genetically related Prader-Willi syndrome. It usually manifests at birth with muscular hypotonia in all and distal joint contractures in a majority of affected individuals. Gastrointestinal/feeding problems are particularly pronounced in infancy and childhood, but can transition to hyperphagia and obesity in adulthood. Respiratory distress is present in many individuals at birth, with approximately half requiring intubation and mechanical ventilation, and approximately 20% requiring tracheostomy. Skeletal manifestations such as joint contractures, scoliosis, and decreased bone mineral density are frequently observed. All affected individuals show developmental delay, resulting in intellectual disability of variable degree, from low-normal intelligence to severe intellectual disability. Other findings may include short stature, seizures, eye anomalies, and hypogonadism.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1807366">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_444067" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cleft lip/palate-ectodermal dysplasia syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_477139" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Multiple congenital anomalies-hypotonia-seizures syndrome 2</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1807366" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Schaaf-Yang syndrome</a></div></div>
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</div>
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<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37552068">Prenatal diagnosis of cleft lip and/or palate: What do we tell prospective parents?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wilkes C,
|
||
Graetz M,
|
||
Downie L,
|
||
Bethune M,
|
||
Chong D</span><br />
|
||
<span class="medgenPMjournal">Prenat Diagn</span>
|
||
2023 Sep;43(10):1310-1319.
|
||
Epub 2023 Aug 8
|
||
doi: 10.1002/pd.6418.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37552068" target="_blank">37552068</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19898712">Excessive gingival display--etiology, diagnosis, and treatment modalities.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Silberberg N,
|
||
Goldstein M,
|
||
Smidt A</span><br />
|
||
<span class="medgenPMjournal">Quintessence Int</span>
|
||
2009 Nov-Dec;40(10):809-18.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19898712" target="_blank">19898712</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12557035">Prenatal diagnosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Paek B,
|
||
Goldberg JD,
|
||
Albanese CT</span><br />
|
||
<span class="medgenPMjournal">World J Surg</span>
|
||
2003 Jan;27(1):27-37.
|
||
doi: 10.1007/s00268-002-6734-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12557035" target="_blank">12557035</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(abnormality%20of%20the%20philtrum)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (761)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/31408229">Diagnosis of fetal non-chromosomal abnormalities on routine ultrasound examination at 11-13 weeks' gestation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Syngelaki A,
|
||
Hammami A,
|
||
Bower S,
|
||
Zidere V,
|
||
Akolekar R,
|
||
Nicolaides KH</span><br />
|
||
<span class="medgenPMjournal">Ultrasound Obstet Gynecol</span>
|
||
2019 Oct;54(4):468-476.
|
||
doi: 10.1002/uog.20844.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31408229" target="_blank">31408229</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29652578">MR Imaging of the Fetal Face: Comprehensive Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nagarajan M,
|
||
Sharbidre KG,
|
||
Bhabad SH,
|
||
Byrd SE</span><br />
|
||
<span class="medgenPMjournal">Radiographics</span>
|
||
2018 May-Jun;38(3):962-980.
|
||
Epub 2018 Apr 13
|
||
doi: 10.1148/rg.2018170142.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29652578" target="_blank">29652578</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25426794">Congenital double upper lip: review of literature and report of a case.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ariyawardana A</span><br />
|
||
<span class="medgenPMjournal">J Investig Clin Dent</span>
|
||
2011 Aug;2(3):212-5.
|
||
Epub 2011 Jun 6
|
||
doi: 10.1111/j.2041-1626.2011.00065.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25426794" target="_blank">25426794</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9020720">Median lip fissure.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rosenquist BE</span><br />
|
||
<span class="medgenPMjournal">J Craniofac Surg</span>
|
||
1995 Sep;6(5):390-1.
|
||
doi: 10.1097/00001665-199509000-00013.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9020720" target="_blank">9020720</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/5234003">A cephalometric investigation of the surgical correction of mandibular prognathism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Aaronson SA</span><br />
|
||
<span class="medgenPMjournal">Angle Orthod</span>
|
||
1967 Oct;37(4):251-60.
|
||
doi: 10.1043/0003-3219(1967)037<0251:ACIOTS>2.0.CO;2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/5234003" target="_blank">5234003</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormality%20of%20the%20philtrum%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (8232)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39381977">A Rorschach Test.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Caluseriu O</span><br />
|
||
<span class="medgenPMjournal">Am J Med Genet C Semin Med Genet</span>
|
||
2024 Nov;196(2-3):e32116.
|
||
Epub 2024 Oct 9
|
||
doi: 10.1002/ajmg.c.32116.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39381977" target="_blank">39381977</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37603894">Median Cleft Lip.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Menderes A,
|
||
Ateşşahin FB,
|
||
Babahan T,
|
||
Terzi M,
|
||
Atalmiş SE,
|
||
Çağli HB</span><br />
|
||
<span class="medgenPMjournal">J Craniofac Surg</span>
|
||
2023 Nov-Dec 01;34(8):e780-e781.
|
||
Epub 2023 Aug 21
|
||
doi: 10.1097/SCS.0000000000009647.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37603894" target="_blank">37603894</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31408229">Diagnosis of fetal non-chromosomal abnormalities on routine ultrasound examination at 11-13 weeks' gestation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Syngelaki A,
|
||
Hammami A,
|
||
Bower S,
|
||
Zidere V,
|
||
Akolekar R,
|
||
Nicolaides KH</span><br />
|
||
<span class="medgenPMjournal">Ultrasound Obstet Gynecol</span>
|
||
2019 Oct;54(4):468-476.
|
||
doi: 10.1002/uog.20844.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31408229" target="_blank">31408229</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20920258">Acro-cardio-facial syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Digilio MC,
|
||
Dallapiccola B</span><br />
|
||
<span class="medgenPMjournal">Orphanet J Rare Dis</span>
|
||
2010 Sep 29;5:25.
|
||
doi: 10.1186/1750-1172-5-25.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20920258" target="_blank">20920258</a><a href="/pmc/articles/PMC2955584" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12557035">Prenatal diagnosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Paek B,
|
||
Goldberg JD,
|
||
Albanese CT</span><br />
|
||
<span class="medgenPMjournal">World J Surg</span>
|
||
2003 Jan;27(1):27-37.
|
||
doi: 10.1007/s00268-002-6734-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12557035" target="_blank">12557035</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormality%20of%20the%20philtrum%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3809)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36198659">Combination technique of polidocanol sclerotherapy and radiofrequency ablation in venous malformations of lip.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Khunger N,
|
||
Dhattarwal N</span><br />
|
||
<span class="medgenPMjournal">Dermatol Ther</span>
|
||
2022 Dec;35(12):e15904.
|
||
Epub 2022 Oct 17
|
||
doi: 10.1111/dth.15904.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36198659" target="_blank">36198659</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34282604">Environmental and Genetic Risk Factors of Congenital Anomalies: an Umbrella Review of Systematic Reviews and Meta-Analyses.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee KS,
|
||
Choi YJ,
|
||
Cho J,
|
||
Lee H,
|
||
Lee H,
|
||
Park SJ,
|
||
Park JS,
|
||
Hong YC</span><br />
|
||
<span class="medgenPMjournal">J Korean Med Sci</span>
|
||
2021 Jul 19;36(28):e183.
|
||
doi: 10.3346/jkms.2021.36.e183.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34282604" target="_blank">34282604</a><a href="/pmc/articles/PMC8289720" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33369213">Evaluation of upper labial frenectomy: A randomized, controlled comparative study of conventional scalpel technique and Er:YAG laser technique.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sarmadi R,
|
||
Gabre P,
|
||
Thor A</span><br />
|
||
<span class="medgenPMjournal">Clin Exp Dent Res</span>
|
||
2021 Aug;7(4):522-530.
|
||
Epub 2020 Dec 25
|
||
doi: 10.1002/cre2.374.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33369213" target="_blank">33369213</a><a href="/pmc/articles/PMC8404491" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26662928">Effects and safety of periconceptional oral folate supplementation for preventing birth defects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">De-Regil LM,
|
||
Peña-Rosas JP,
|
||
Fernández-Gaxiola AC,
|
||
Rayco-Solon P</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2015 Dec 14;2015(12):CD007950.
|
||
doi: 10.1002/14651858.CD007950.pub3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26662928" target="_blank">26662928</a><a href="/pmc/articles/PMC8783750" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/4354695">Phenocopies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lenz W</span><br />
|
||
<span class="medgenPMjournal">J Med Genet</span>
|
||
1973 Mar;10(1):34-49.
|
||
doi: 10.1136/jmg.10.1.34.
|
||
<span class="bold">PMID: </span><a href="/pubmed/4354695" target="_blank">4354695</a><a href="/pmc/articles/PMC1012974" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormality%20of%20the%20philtrum%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2137)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37603894">Median Cleft Lip.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Menderes A,
|
||
Ateşşahin FB,
|
||
Babahan T,
|
||
Terzi M,
|
||
Atalmiş SE,
|
||
Çağli HB</span><br />
|
||
<span class="medgenPMjournal">J Craniofac Surg</span>
|
||
2023 Nov-Dec 01;34(8):e780-e781.
|
||
Epub 2023 Aug 21
|
||
doi: 10.1097/SCS.0000000000009647.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37603894" target="_blank">37603894</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30396411">Cleft Lip and Palate.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Worley ML,
|
||
Patel KG,
|
||
Kilpatrick LA</span><br />
|
||
<span class="medgenPMjournal">Clin Perinatol</span>
|
||
2018 Dec;45(4):661-678.
|
||
Epub 2018 Sep 18
|
||
doi: 10.1016/j.clp.2018.07.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30396411" target="_blank">30396411</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11463968">Congenital cricopharyngeal achalasia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mathur NB,
|
||
Banerjee S,
|
||
Maria A,
|
||
Bhatnagar V</span><br />
|
||
<span class="medgenPMjournal">Indian Pediatr</span>
|
||
2001 Jul;38(7):783-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11463968" target="_blank">11463968</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/4116552">Maternal epilepsy and abnormalities of the fetus and newborn.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Speidel BD,
|
||
Meadow SR</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
1972 Oct 21;2(7782):839-43.
|
||
doi: 10.1016/s0140-6736(72)92209-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/4116552" target="_blank">4116552</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/14339244">RARE CLEFTS OF THE FACE.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">FOGH-ANDERSEN P</span><br />
|
||
<span class="medgenPMjournal">Acta Chir Scand</span>
|
||
1965 Mar;129:275-81.
|
||
<span class="bold">PMID: </span><a href="/pubmed/14339244" target="_blank">14339244</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormality%20of%20the%20philtrum%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2933)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36877617">Lip-Shortening Surgery.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gatti JE</span><br />
|
||
<span class="medgenPMjournal">Plast Reconstr Surg</span>
|
||
2023 Oct 1;152(4):765-772.
|
||
Epub 2023 Mar 7
|
||
doi: 10.1097/PRS.0000000000010361.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36877617" target="_blank">36877617</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35034947">Epidemiology of Birth Defects in Eastern China and the Associated Risk Factors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang QQ,
|
||
He CY,
|
||
Mei J,
|
||
Xu YL</span><br />
|
||
<span class="medgenPMjournal">Med Sci Monit</span>
|
||
2022 Jan 17;28:e933782.
|
||
doi: 10.12659/MSM.933782.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35034947" target="_blank">35034947</a><a href="/pmc/articles/PMC8779999" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3050099">The telecanthus-hypospadias syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stevens CA,
|
||
Wilroy RS Jr</span><br />
|
||
<span class="medgenPMjournal">J Med Genet</span>
|
||
1988 Aug;25(8):536-42.
|
||
doi: 10.1136/jmg.25.8.536.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3050099" target="_blank">3050099</a><a href="/pmc/articles/PMC1080030" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/14211086">THE FACE PREDICTS THE BRAIN: DIAGNOSTIC SIGNIFICANCE OF MEDIAN FACIAL ANOMALIES FOR HOLOPROSENCEPHALY (ARHINENCEPHALY).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">DEMYER W,
|
||
ZEMAN W,
|
||
PALMER CG</span><br />
|
||
<span class="medgenPMjournal">Pediatrics</span>
|
||
1964 Aug;34:256-63.
|
||
<span class="bold">PMID: </span><a href="/pubmed/14211086" target="_blank">14211086</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/13064045">Further observations on the use of the split vermilion bordered flap.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">CANNON B,
|
||
MURRAY JE</span><br />
|
||
<span class="medgenPMjournal">Plast Reconstr Surg (1946)</span>
|
||
1953 Jun;11(6):497-501.
|
||
doi: 10.1097/00006534-195306000-00007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/13064045" target="_blank">13064045</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormality%20of%20the%20philtrum%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4121)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/35248905">Association between superior labial frenum and maxillary midline diastema - a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tadros S,
|
||
Ben-Dov T,
|
||
Catháin ÉÓ,
|
||
Anglin C,
|
||
April MM</span><br />
|
||
<span class="medgenPMjournal">Int J Pediatr Otorhinolaryngol</span>
|
||
2022 May;156:111063.
|
||
Epub 2022 Feb 26
|
||
doi: 10.1016/j.ijporl.2022.111063.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35248905" target="_blank">35248905</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34033944">Global prevalence of cleft palate, cleft lip and cleft palate and lip: A comprehensive systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Salari N,
|
||
Darvishi N,
|
||
Heydari M,
|
||
Bokaee S,
|
||
Darvishi F,
|
||
Mohammadi M</span><br />
|
||
<span class="medgenPMjournal">J Stomatol Oral Maxillofac Surg</span>
|
||
2022 Apr;123(2):110-120.
|
||
Epub 2021 May 24
|
||
doi: 10.1016/j.jormas.2021.05.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34033944" target="_blank">34033944</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34282604">Environmental and Genetic Risk Factors of Congenital Anomalies: an Umbrella Review of Systematic Reviews and Meta-Analyses.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee KS,
|
||
Choi YJ,
|
||
Cho J,
|
||
Lee H,
|
||
Lee H,
|
||
Park SJ,
|
||
Park JS,
|
||
Hong YC</span><br />
|
||
<span class="medgenPMjournal">J Korean Med Sci</span>
|
||
2021 Jul 19;36(28):e183.
|
||
doi: 10.3346/jkms.2021.36.e183.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34282604" target="_blank">34282604</a><a href="/pmc/articles/PMC8289720" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30721300">Will This Patient Be Difficult to Intubate?: The Rational Clinical Examination Systematic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Detsky ME,
|
||
Jivraj N,
|
||
Adhikari NK,
|
||
Friedrich JO,
|
||
Pinto R,
|
||
Simel DL,
|
||
Wijeysundera DN,
|
||
Scales DC</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2019 Feb 5;321(5):493-503.
|
||
doi: 10.1001/jama.2018.21413.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30721300" target="_blank">30721300</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26997574">Feeding methods for children with cleft lip and/or palate: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Duarte GA,
|
||
Ramos RB,
|
||
Cardoso MC</span><br />
|
||
<span class="medgenPMjournal">Braz J Otorhinolaryngol</span>
|
||
2016 Sep-Oct;82(5):602-9.
|
||
Epub 2016 Mar 2
|
||
doi: 10.1016/j.bjorl.2015.10.020.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26997574" target="_blank">26997574</a><a href="/pmc/articles/PMC9444722" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormality%20of%20the%20philtrum%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (308)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
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|
||
|
||
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|
||
<div class=" bottom">
|
||
|
||
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|
||
|
||
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|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
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||
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|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C1857045%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (2)</a></li>
|
||
<li><a href="/gtr/tests?term=C1857045%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (2)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C1857045%5bDISCUI%5d" target="_blank">See all (2)</a></total></li>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Abnormality%20of%20the%20philtrum" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(abnormality%20of%20the%20philtrum)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Abnormality%20of%20the%20philtrum%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<ul>
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<li>
|
||
<a href="/pubmed/clinical?term=Abnormality%20of%20the%20philtrum" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
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</li>
|
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<li>
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<a href="/pubmed?term=Abnormality%20of%20the%20philtrum%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
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|
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|
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<h3>Related information</h3>
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<div class="portlet_content DiscoveryDbLinks">
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<ul>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C1857045[DISCUI]" ref="log$=recordlinks">GTR</a>
|
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<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
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||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C1857045[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
|
||
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<a class="brieflinkpopperctrl" href="/pmc?LinkName=medgen_pmc&from_uid=384043" ref="log$=recordlinks">PMC Articles</a>
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<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed&from_uid=384043" ref="log$=recordlinks">PubMed</a>
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<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
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||
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<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory">
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Clear
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Turn On
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<ul id="activity">
|
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<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67d6381dcde49f3df7265c8b">Abnormality of the philtrum</a>
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<div class="ralinkpop offscreen_noflow">Abnormality of the philtrum<div class="brieflinkpopdesc"></div></div>
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||
<div class="tertiary">MedGen</div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67d6381a84f3725e597752a0">Long palpebral fissure</a>
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<div class="ralinkpop offscreen_noflow">Long palpebral fissure<div class="brieflinkpopdesc"></div></div>
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<div class="tertiary">MedGen</div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67d6381984f3725e59774ee9">Anodontia</a>
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