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<!--
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UID=383834
|
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ConceptID=C1856087
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Biconcave vertebral bodies</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>383834</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1856087</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Biconcave 'codfish' vertebrae; Biconcave vertebrae; Codfish vertebrae; Scalloping of vertebral bodies; Vertebral body scalloping</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0004586">HP:0004586</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">Exaggerated concavity of the anterior or posterior surface of the vertebral body, i.e., the upper and lower vertebral endplates are hollowed inward. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Biconcave vertebral bodies</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867418" ref="tree=MeSH" title="MedGen record for Abnormality of the skeletal system">Abnormality of the skeletal system</a></span><ul><li><span class="TLline"><a href="/medgen/868760" ref="tree=MeSH" title="MedGen record for Abnormal skeletal morphology">Abnormal skeletal morphology</a></span><ul><li><span class="TLline"><a href="/medgen/892434" ref="tree=MeSH" title="MedGen record for Abnormal axial skeleton morphology">Abnormal axial skeleton morphology</a></span><ul><li><span class="TLline"><a href="/medgen/892426" ref="tree=MeSH" title="MedGen record for Abnormality of the vertebral column">Abnormality of the vertebral column</a></span><ul><li><span class="TLline"><a href="/medgen/371742" ref="tree=MeSH" title="MedGen record for Abnormal vertebral morphology">Abnormal vertebral morphology</a></span><ul><li><span class="TLline"><a href="/medgen/374194" ref="tree=MeSH" title="MedGen record for Abnormal form of the vertebral bodies">Abnormal form of the vertebral bodies</a></span><ul><li><span class="matched_ds">Biconcave vertebral bodies</span><ul><li><span class="TLline"><a href="/medgen/435977" ref="tree=MeSH" title="MedGen record for Anterior scalloping of vertebral bodies">Anterior scalloping of vertebral bodies</a></span></li><li><span class="TLline"><a href="/medgen/318956" ref="tree=MeSH" title="MedGen record for Biconcave flattened vertebrae">Biconcave flattened vertebrae</a></span></li><li><span class="TLline"><a href="/medgen/337993" ref="tree=MeSH" title="MedGen record for Posterior scalloping of vertebral bodies">Posterior scalloping of vertebral bodies</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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||
<div class="divPopper rprt" id="rdis_39698"><div><strong>Hurler syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>39698</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0086795</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Mucopolysaccharidosis type I (MPS I) is a progressive multisystem disorder with features ranging over a continuum of severity. While affected individuals have traditionally been classified as having one of three MPS I syndromes (Hurler syndrome, Hurler-Scheie syndrome, or Scheie syndrome), no easily measurable biochemical differences have been identified and the clinical findings overlap. Affected individuals are best described as having either a phenotype consistent with either severe (Hurler syndrome) or attenuated MPS I, a distinction that influences therapeutic options. Severe MPS I: Infants appear normal at birth. Typical early manifestations are nonspecific (e.g., umbilical or inguinal hernia, frequent upper respiratory tract infections before age 1 year). Coarsening of the facial features may not become apparent until after age one year. Gibbus deformity of the lower spine is common and often noted within the first year. Progressive skeletal dysplasia (dysostosis multiplex) involving all bones is universal, as is progressive arthropathy involving most joints. By age three years, linear growth decreases. Intellectual disability is progressive and profound but may not be readily apparent in the first year of life. Progressive cardiorespiratory involvement, hearing loss, and corneal clouding are common. Without treatment, death (typically from cardiorespiratory failure) usually occurs within the first ten years of life. Attenuated MPS I: Clinical onset is usually between ages three and ten years. The severity and rate of disease progression range from serious life-threatening complications leading to death in the second to third decade, to a normal life span complicated by significant disability from progressive joint manifestations and cardiorespiratory disease. While some individuals have no neurologic involvement and psychomotor development may be normal in early childhood, learning disabilities and psychiatric manifestations can be present later in life. Hearing loss, cardiac valvular disease, respiratory involvement, and corneal clouding are common.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/39698">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_66381"><div><strong>Pituitary dependent hypercortisolism</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>66381</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0221406</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Adrenocorticotropic hormone (ACTH) hypersecretion by corticotroph adenomas of the pituitary result in excess cortisol secretion, or Cushing disease. The clinical features of Cushing disease include central obesity, moon facies, 'buffalo hump,' diabetes, hypertension, fatigue, easy bruising, depression, and reproductive disorders. Cushing disease is associated with increased morbidity and mortality, mainly due to cardiovascular or cerebrovascular disease and infections (summary by Perez-Rivas et al., 2015). Mutations in the USP8 gene, leading to an upregulated epidermal growth factor receptor (EGFR; 131550) pathway, have been identified in about 36 to 62% of corticotroph adenomas (summary by Mete and Lopes, 2017).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/66381">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_78664"><div><strong>Osteogenesis imperfecta type III</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>78664</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0268362</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">COL1A1/2 osteogenesis imperfecta (COL1A1/2-OI) is characterized by fractures with minimal or absent trauma, variable dentinogenesis imperfecta (DI), and, in adult years, hearing loss. The clinical features of COL1A1/2-OI represent a continuum ranging from perinatal lethality to individuals with severe skeletal deformities, mobility impairments, and very short stature to nearly asymptomatic individuals with a mild predisposition to fractures, normal dentition, normal stature, and normal life span. Fractures can occur in any bone but are most common in the extremities. DI is characterized by gray or brown teeth that may appear translucent, wear down, and break easily. COL1A1/2-OI has been classified into four types based on clinical presentation and radiographic findings. This classification system can be helpful in providing information about prognosis and management for a given individual. The four more common OI types are now referred to as follows: Classic non-deforming OI with blue sclerae (previously OI type I). Perinatally lethal OI (previously OI type II). Progressively deforming OI (previously OI type III). Common variable OI with normal sclerae (previously OI type IV).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/78664">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_98480"><div><strong>Osteoporosis with pseudoglioma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>98480</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0432252</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Osteoporosis-pseudoglioma syndrome (OPPG) is an autosomal recessive disorder characterized by severe osteoporosis and visual disturbance from childhood. Juvenile onset of osteoporosis manifests as long-bone fractures, vertebral compression fractures, kyphoscoliosis, deformity of extremities, and short stature. Congenital or early-onset visual disturbances arise from ophthalmologic problems including retinal detachment and microphthalmia (summary by Narumi et al., 2010).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/98480">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_98149"><div><strong>Geroderma osteodysplastica</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>98149</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0432255</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Geroderma osteodysplasticum (GO) is an autosomal recessive disorder characterized by skin wrinkling limited to the dorsa of hands and feet and to the abdomen, bowed long bones, and osteopenia with frequent fractures. There is a distinctive facial appearance with droopy skin at the cheeks, maxillary hypoplasia, and large ears. Adult patients appear prematurely aged (summary by Rajab et al., 2008).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/98149">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_199606"><div><strong>Classic homocystinuria</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>199606</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0751202</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Homocystinuria caused by cystathionine ß-synthase (CBS) deficiency is characterized by involvement of the eye (ectopia lentis and/or severe myopia), skeletal system (excessive height, long limbs, scolioisis, and pectus excavatum), vascular system (thromboembolism), and CNS (developmental delay/intellectual disability). All four ? or only one ? of the systems can be involved; expressivity is variable for all of the clinical signs. It is not unusual for a previously asymptomatic individual to present in adult years with only a thromboembolic event that is often cerebrovascular. Two phenotypic variants are recognized, B6-responsive homocystinuria and B6-non-responsive homocystinuria. B6-responsive homocystinuria is usually milder than the non-responsive variant. Thromboembolism is the major cause of early death and morbidity. IQ in individuals with untreated homocystinuria ranges widely, from 10 to 138. In B6-responsive individuals the mean IQ is 79 versus 57 for those who are B6-non-responsive. Other features that may occur include: seizures, psychiatric problems, extrapyramidal signs (e.g., dystonia), hypopigmentation of the skin and hair, malar flush, livedo reticularis, and pancreatitis.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/199606">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_182961"><div><strong>Hajdu-Cheney syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>182961</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0917715</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hajdu-Cheney syndrome (HJCYS) is a rare autosomal dominant skeletal disorder characterized by short stature, coarse and dysmorphic facies, bowing of the long bones, and vertebral anomalies. Facial features include hypertelorism, bushy eyebrows, micrognathia, small mouth with dental anomalies, low-set ears, and short neck. There is progressive focal bone destruction, including acroosteolysis and generalized osteoporosis. Additional and variable features include hearing loss, renal cysts, and cardiovascular anomalies (summary by Ramos et al., 1998; Simpson et al., 2011; Isidor et al., 2011).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/182961">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_266247"><div><strong>Sponastrime dysplasia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>266247</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1300260</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Sponastrime dysplasia is an autosomal recessive spondyloepimetaphyseal dysplasia (SEMD) named for characteristic clinical and radiographic findings, including spine (spondylar) abnormalities, midface hypoplasia with a depressed nasal bridge, and striation of the metaphyses. Additional features include disproportionate short stature with exaggerated lumbar lordosis, scoliosis, coxa vara, limited elbow extension, small dysplastic epiphyses, childhood cataracts, short dental roots, and hypogammaglobulinemia. Radiographically, the abnormalities of the lumbar vertebral bodies are suggested to be the most specific finding because the characteristic metaphyseal striations may not be apparent at young ages. Striking clinical variability in presentation, severity, and associated features has been observed (summary by Burrage et al., 2019).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/266247">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_342070"><div><strong>Lateral meningocele syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>342070</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1851710</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">NOTCH3-related lateral meningocele syndrome (LMS) is characterized by multiple lateral spinal meningoceles (protrusions of the arachnoid and dura through spinal foramina), distinctive facial features, joint hyperextensibility, hypotonia, and skeletal, cardiac, and urogenital anomalies. Neurologic sequelæ of the meningoceles depend on size and location and can include neurogenic bladder, paresthesia, back pain, and/or paraparesis. Other neurologic findings can include Chiari I malformation, syringomyelia, and rarely, hydrocephalus. Additional findings of LMS include developmental delay, mixed or conductive hearing loss, and cleft palate. Skeletal abnormalities may include scoliosis, vertebral fusion, scalloping of vertebrae, and wormian bones. Infants may demonstrate feeding difficulties with poor weight gain.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/342070">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_419332"><div><strong>Osteogenesis imperfecta type 5</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>419332</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2931093</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Osteogenesis imperfecta (OI) is a connective tissue disorder characterized by bone fragility and low bone mass. Due to considerable phenotypic variability, Sillence et al. (1979) developed a classification of OI subtypes based on clinical features and disease severity: OI type I, with blue sclerae (166200); perinatal lethal OI type II, also known as congenital OI (166210); OI type III, a progressively deforming form with normal sclerae (259420); and OI type IV, with normal sclerae (166220). Most forms of OI are autosomal dominant with mutations in one of the 2 genes that code for type I collagen alpha chains, COL1A1 (120150) and COL1A2 (120160). Glorieux et al. (2000) described a novel autosomal dominant form of OI, which they designated OI type V (OI5), in 7 patients. The disorder was similar to OI type IV but had distinctive clinical, histologic, and molecular characteristics. OI type V is characterized by calcification of the forearm interosseous membrane, radial head dislocation, a subphyseal metaphyseal radiodense line, and hyperplastic callus formation (summary by Cho et al., 2012). OI type V has a variable phenotype. For example, in patients with the more common c.-14C-T variant (614757.0001), distinctive radiographic findings (calcification of the forearm interosseous membrane, radial head dislocation, a subphyseal metaphyseal radiodense line, and hyperplastic callus formation) are often seen, whereas these findings are not seen in patients with the less common S40L variant (614757.0002).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/419332">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_462568"><div><strong>Osteogenesis imperfecta type 11</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462568</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3151218</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Osteogenesis imperfecta (OI) comprises a group of connective tissue disorders characterized by bone fragility and low bone mass. The disorder is clinically and genetically heterogeneous. OI type XI is an autosomal recessive form of OI (summary by Alanay et al., 2010).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462568">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_481194"><div><strong>Osteogenesis imperfecta type 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>481194</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3279564</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Osteogenesis imperfecta (OI) comprises a group of connective tissue disorders characterized by bone fragility and low bone mass. The disorder is clinically and genetically heterogeneous. Osteogenesis imperfecta type VI is a severe autosomal recessive form of the disorder (Glorieux et al., 2002; Becker et al., 2011).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/481194">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1635201"><div><strong>Osteogenesis imperfecta, type 18</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1635201</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4693736</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Osteogenesis imperfecta type XVIII (OI18) is characterized by congenital bowing of the long bones, wormian bones, blue sclerae, vertebral collapse, and multiple fractures in the first years of life (Doyard et al., 2018).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1635201">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1648353"><div><strong>Osteogenesis imperfecta, type 19</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1648353</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4746956</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Osteogenesis imperfecta type XIX (OI19) is characterized by prenatal fractures and generalized osteopenia, with severe short stature in adulthood, as well as variable scoliosis and pectal deformity, and marked anterior angulation of the tibia (Lindert et al., 2016).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1648353">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1780157"><div><strong>Spondyloepiphyseal dysplasia, sensorineural hearing loss, impaired intellectual development, and leber congenital amaurosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1780157</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5543257</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">SHILCA is characterized by early-onset retinal degeneration in association with sensorineural hearing loss, short stature, vertebral anomalies, and epiphyseal dysplasia, as well as motor and intellectual delay. Delayed myelination, leukoencephalopathy, and hypoplasia of the corpus callosum and cerebellum have been observed on brain MRI (Bedoni et al., 2020).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1780157">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_199606" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Classic homocystinuria</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_98149" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Geroderma osteodysplastica</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_182961" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hajdu-Cheney syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_39698" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hurler syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_342070" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Lateral meningocele syndrome</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (15)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462568" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Osteogenesis imperfecta type 11</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_419332" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Osteogenesis imperfecta type 5</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_481194" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Osteogenesis imperfecta type 6</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_78664" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Osteogenesis imperfecta type III</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1635201" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Osteogenesis imperfecta, type 18</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1648353" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Osteogenesis imperfecta, type 19</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_98480" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Osteoporosis with pseudoglioma</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_66381" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pituitary dependent hypercortisolism</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_266247" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Sponastrime dysplasia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1780157" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Spondyloepiphyseal dysplasia, sensorineural hearing loss, impaired intellectual development, and leber congenital amaurosis</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
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||
<div class="nl"><a target="_blank" href="/pubmed/21705031">Lateral spine radiographs before androgen deprivation treatment detect a high incidence of undiagnosed vertebral fragility fractures in men with advanced prostate cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mistry R,
|
||
Hughes D,
|
||
Wadhwa V,
|
||
Parr N</span><br />
|
||
<span class="medgenPMjournal">J Urol</span>
|
||
2011 Aug;186(2):474-80.
|
||
Epub 2011 Jun 25
|
||
doi: 10.1016/j.juro.2011.03.149.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21705031" target="_blank">21705031</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1583055">Osteogenesis imperfecta. Radiographic classification, natural history, and treatment of spinal deformities.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hanscom DA,
|
||
Winter RB,
|
||
Lutter L,
|
||
Lonstein JE,
|
||
Bloom BA,
|
||
Bradford DS</span><br />
|
||
<span class="medgenPMjournal">J Bone Joint Surg Am</span>
|
||
1992 Apr;74(4):598-616.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1583055" target="_blank">1583055</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(biconcave%20vertebral%20bodies)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (2)</a></div></div>
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</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/28508265">Incidence of Vertebral Fractures in Women with Systemic Lupus Erythematosus After 8 Years of Follow-Up.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">García-Carrasco M,
|
||
Mendoza-Pinto C,
|
||
León-Vázquez ML,
|
||
Méndez-Martínez S,
|
||
Etchegaray-Morales I,
|
||
Montiel-Jarquín Á,
|
||
Enriquez-Guerra MA,
|
||
Muñóz-Guarneros M,
|
||
Gálvez-Romero JL,
|
||
Soto-Santillán P,
|
||
Cervera R</span><br />
|
||
<span class="medgenPMjournal">Calcif Tissue Int</span>
|
||
2017 Sep;101(3):291-299.
|
||
Epub 2017 May 15
|
||
doi: 10.1007/s00223-017-0286-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28508265" target="_blank">28508265</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26935460">Characteristics of Prevalent Vertebral Fractures Predict New Fractures in Elderly Men.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Karlsson MK,
|
||
Kherad M,
|
||
Hasserius R,
|
||
Nilsson JÅ,
|
||
Redlund-Johnell I,
|
||
Ohlsson C,
|
||
Lorentzon M,
|
||
Mellström D,
|
||
Rosengren BE</span><br />
|
||
<span class="medgenPMjournal">J Bone Joint Surg Am</span>
|
||
2016 Mar 2;98(5):379-85.
|
||
doi: 10.2106/JBJS.15.00328.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26935460" target="_blank">26935460</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24280137">Is balloon kyphoplasty better than percutaneous vertebroplasty for osteoporotic vertebral biconcave-shaped fractures?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gan M,
|
||
Zou J,
|
||
Song D,
|
||
Zhu X,
|
||
Wang G,
|
||
Yang H</span><br />
|
||
<span class="medgenPMjournal">Acta Radiol</span>
|
||
2014 Oct;55(8):985-91.
|
||
Epub 2013 Nov 26
|
||
doi: 10.1177/0284185113511603.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24280137" target="_blank">24280137</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22825483">Quantitative vertebral morphometry based on parametric modeling of vertebral bodies in 3D.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stern D,
|
||
Njagulj V,
|
||
Likar B,
|
||
Pernuš F,
|
||
Vrtovec T</span><br />
|
||
<span class="medgenPMjournal">Osteoporos Int</span>
|
||
2013 Apr;24(4):1357-68.
|
||
Epub 2012 Jul 24
|
||
doi: 10.1007/s00198-012-2089-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22825483" target="_blank">22825483</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22914705">Morphological changes of lumbar vertebral bodies and intervertebral discs associated with decrease in bone mineral density of the spine: a cross-sectional study in elderly subjects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kwok AW,
|
||
Wang YX,
|
||
Griffith JF,
|
||
Deng M,
|
||
Leung JC,
|
||
Ahuja AT,
|
||
Leung PC</span><br />
|
||
<span class="medgenPMjournal">Spine (Phila Pa 1976)</span>
|
||
2012 Nov 1;37(23):E1415-21.
|
||
doi: 10.1097/BRS.0b013e31826f561e.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22914705" target="_blank">22914705</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Biconcave%20vertebral%20bodies%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (27)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/29497872">Morphometric semi-quantitative assessment of vertebral fractures in postmenopausal black women in Central Africa.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kabenkama JMK,
|
||
Banza L,
|
||
Tshibola JM,
|
||
Muamba JM,
|
||
Tozin RR,
|
||
Tshikwela ML</span><br />
|
||
<span class="medgenPMjournal">Arch Osteoporos</span>
|
||
2018 Mar 1;13(1):13.
|
||
doi: 10.1007/s11657-018-0431-y.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29497872" target="_blank">29497872</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26008684">Radiologic and clinical characteristics of vertebral fractures in multiple myeloma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Miller JA,
|
||
Bowen A,
|
||
Morisada MV,
|
||
Margetis K,
|
||
Lubelski D,
|
||
Lieberman IH,
|
||
Benzel EC,
|
||
Mroz TE</span><br />
|
||
<span class="medgenPMjournal">Spine J</span>
|
||
2015 Oct 1;15(10):2149-56.
|
||
Epub 2015 May 22
|
||
doi: 10.1016/j.spinee.2015.05.026.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26008684" target="_blank">26008684</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22825483">Quantitative vertebral morphometry based on parametric modeling of vertebral bodies in 3D.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stern D,
|
||
Njagulj V,
|
||
Likar B,
|
||
Pernuš F,
|
||
Vrtovec T</span><br />
|
||
<span class="medgenPMjournal">Osteoporos Int</span>
|
||
2013 Apr;24(4):1357-68.
|
||
Epub 2012 Jul 24
|
||
doi: 10.1007/s00198-012-2089-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22825483" target="_blank">22825483</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7570153">Lumbar spine in Marfan syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tallroth K,
|
||
Malmivaara A,
|
||
Laitinen ML,
|
||
Savolainen A,
|
||
Harilainen A</span><br />
|
||
<span class="medgenPMjournal">Skeletal Radiol</span>
|
||
1995 Jul;24(5):337-40.
|
||
doi: 10.1007/BF00197061.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7570153" target="_blank">7570153</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1576014">Measurements of bone mineral density by DXA total body absorptiometry in different skeletal sites in postmenopausal osteoporosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nuti R,
|
||
Martini G</span><br />
|
||
<span class="medgenPMjournal">Bone</span>
|
||
1992;13(2):173-8.
|
||
doi: 10.1016/8756-3282(92)90008-k.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1576014" target="_blank">1576014</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Biconcave%20vertebral%20bodies%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (13)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37203859">Factors affecting cement leakage in percutaneous vertebroplasty: a retrospective cohort study of 309 patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hou JG,
|
||
Zhang N,
|
||
Chen GD</span><br />
|
||
<span class="medgenPMjournal">Eur Rev Med Pharmacol Sci</span>
|
||
2023 May;27(9):3877-3886.
|
||
doi: 10.26355/eurrev_202305_32293.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37203859" target="_blank">37203859</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28640112">Cement leakage in osteoporotic vertebral compression fractures with cortical defect using high-viscosity bone cement during unilateral percutaneous kyphoplasty surgery.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Liu T,
|
||
Li Z,
|
||
Su Q,
|
||
Hai Y</span><br />
|
||
<span class="medgenPMjournal">Medicine (Baltimore)</span>
|
||
2017 Jun;96(25):e7216.
|
||
doi: 10.1097/MD.0000000000007216.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28640112" target="_blank">28640112</a><a href="/pmc/articles/PMC5484220" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23927056">Radiographic and safety details of vertebral body stenting: results from a multicenter chart review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Diel P,
|
||
Röder C,
|
||
Perler G,
|
||
Vordemvenne T,
|
||
Scholz M,
|
||
Kandziora F,
|
||
Fürderer S,
|
||
Eiskjaer S,
|
||
Maestretti G,
|
||
Rotter R,
|
||
Benneker LM,
|
||
Heini PF</span><br />
|
||
<span class="medgenPMjournal">BMC Musculoskelet Disord</span>
|
||
2013 Aug 8;14:233.
|
||
doi: 10.1186/1471-2474-14-233.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23927056" target="_blank">23927056</a><a href="/pmc/articles/PMC3751159" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16168271">Comparison of vertebral morphometry in the lumbar vertebrae by T1-weighted sagittal MRI and radiograph.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tomomitsu T,
|
||
Murase K,
|
||
Sone T,
|
||
Fukunaga M</span><br />
|
||
<span class="medgenPMjournal">Eur J Radiol</span>
|
||
2005 Oct;56(1):102-6.
|
||
Epub 2005 Jan 19
|
||
doi: 10.1016/j.ejrad.2004.12.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16168271" target="_blank">16168271</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10450408">Number and type of vertebral deformities: epidemiological characteristics and relation to back pain and height loss. European Vertebral Osteoporosis Study Group.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ismail AA,
|
||
Cooper C,
|
||
Felsenberg D,
|
||
Varlow J,
|
||
Kanis JA,
|
||
Silman AJ,
|
||
O'Neill TW</span><br />
|
||
<span class="medgenPMjournal">Osteoporos Int</span>
|
||
1999;9(3):206-13.
|
||
doi: 10.1007/s001980050138.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10450408" target="_blank">10450408</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Biconcave%20vertebral%20bodies%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (11)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/28508265">Incidence of Vertebral Fractures in Women with Systemic Lupus Erythematosus After 8 Years of Follow-Up.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">García-Carrasco M,
|
||
Mendoza-Pinto C,
|
||
León-Vázquez ML,
|
||
Méndez-Martínez S,
|
||
Etchegaray-Morales I,
|
||
Montiel-Jarquín Á,
|
||
Enriquez-Guerra MA,
|
||
Muñóz-Guarneros M,
|
||
Gálvez-Romero JL,
|
||
Soto-Santillán P,
|
||
Cervera R</span><br />
|
||
<span class="medgenPMjournal">Calcif Tissue Int</span>
|
||
2017 Sep;101(3):291-299.
|
||
Epub 2017 May 15
|
||
doi: 10.1007/s00223-017-0286-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28508265" target="_blank">28508265</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26935460">Characteristics of Prevalent Vertebral Fractures Predict New Fractures in Elderly Men.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Karlsson MK,
|
||
Kherad M,
|
||
Hasserius R,
|
||
Nilsson JÅ,
|
||
Redlund-Johnell I,
|
||
Ohlsson C,
|
||
Lorentzon M,
|
||
Mellström D,
|
||
Rosengren BE</span><br />
|
||
<span class="medgenPMjournal">J Bone Joint Surg Am</span>
|
||
2016 Mar 2;98(5):379-85.
|
||
doi: 10.2106/JBJS.15.00328.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26935460" target="_blank">26935460</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26008684">Radiologic and clinical characteristics of vertebral fractures in multiple myeloma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Miller JA,
|
||
Bowen A,
|
||
Morisada MV,
|
||
Margetis K,
|
||
Lubelski D,
|
||
Lieberman IH,
|
||
Benzel EC,
|
||
Mroz TE</span><br />
|
||
<span class="medgenPMjournal">Spine J</span>
|
||
2015 Oct 1;15(10):2149-56.
|
||
Epub 2015 May 22
|
||
doi: 10.1016/j.spinee.2015.05.026.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26008684" target="_blank">26008684</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24280137">Is balloon kyphoplasty better than percutaneous vertebroplasty for osteoporotic vertebral biconcave-shaped fractures?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gan M,
|
||
Zou J,
|
||
Song D,
|
||
Zhu X,
|
||
Wang G,
|
||
Yang H</span><br />
|
||
<span class="medgenPMjournal">Acta Radiol</span>
|
||
2014 Oct;55(8):985-91.
|
||
Epub 2013 Nov 26
|
||
doi: 10.1177/0284185113511603.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24280137" target="_blank">24280137</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22825483">Quantitative vertebral morphometry based on parametric modeling of vertebral bodies in 3D.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stern D,
|
||
Njagulj V,
|
||
Likar B,
|
||
Pernuš F,
|
||
Vrtovec T</span><br />
|
||
<span class="medgenPMjournal">Osteoporos Int</span>
|
||
2013 Apr;24(4):1357-68.
|
||
Epub 2012 Jul 24
|
||
doi: 10.1007/s00198-012-2089-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22825483" target="_blank">22825483</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Biconcave%20vertebral%20bodies%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (13)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37203859">Factors affecting cement leakage in percutaneous vertebroplasty: a retrospective cohort study of 309 patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hou JG,
|
||
Zhang N,
|
||
Chen GD</span><br />
|
||
<span class="medgenPMjournal">Eur Rev Med Pharmacol Sci</span>
|
||
2023 May;27(9):3877-3886.
|
||
doi: 10.26355/eurrev_202305_32293.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37203859" target="_blank">37203859</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26515398">Radiographic progression of vertebral fractures in patients with multiple myeloma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Xiao R,
|
||
Miller JA,
|
||
Margetis K,
|
||
Lubelski D,
|
||
Lieberman IH,
|
||
Benzel EC,
|
||
Mroz TE</span><br />
|
||
<span class="medgenPMjournal">Spine J</span>
|
||
2016 Jul;16(7):822-32.
|
||
Epub 2015 Oct 26
|
||
doi: 10.1016/j.spinee.2015.10.033.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26515398" target="_blank">26515398</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26008684">Radiologic and clinical characteristics of vertebral fractures in multiple myeloma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Miller JA,
|
||
Bowen A,
|
||
Morisada MV,
|
||
Margetis K,
|
||
Lubelski D,
|
||
Lieberman IH,
|
||
Benzel EC,
|
||
Mroz TE</span><br />
|
||
<span class="medgenPMjournal">Spine J</span>
|
||
2015 Oct 1;15(10):2149-56.
|
||
Epub 2015 May 22
|
||
doi: 10.1016/j.spinee.2015.05.026.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26008684" target="_blank">26008684</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22825483">Quantitative vertebral morphometry based on parametric modeling of vertebral bodies in 3D.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stern D,
|
||
Njagulj V,
|
||
Likar B,
|
||
Pernuš F,
|
||
Vrtovec T</span><br />
|
||
<span class="medgenPMjournal">Osteoporos Int</span>
|
||
2013 Apr;24(4):1357-68.
|
||
Epub 2012 Jul 24
|
||
doi: 10.1007/s00198-012-2089-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22825483" target="_blank">22825483</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18489984">Influence of age and sex on lumbar vertebral morphometry determined using sagittal magnetic resonance imaging.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sevinc O,
|
||
Barut C,
|
||
Is M,
|
||
Eryoruk N,
|
||
Safak AA</span><br />
|
||
<span class="medgenPMjournal">Ann Anat</span>
|
||
2008;190(3):277-83.
|
||
Epub 2007 Jun 6
|
||
doi: 10.1016/j.aanat.2007.04.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18489984" target="_blank">18489984</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Biconcave%20vertebral%20bodies%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (21)</a></div></div>
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