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<meta name="keywords" content="C1768507, finding, sign or symptom, yellow nails, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Yellowish discoloration of the nails." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Yellow nails (Concept Id: C1768507)
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<!--
UID=369197
ConceptID=C1768507
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Yellow nails</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>369197</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1768507</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding; Sign or Symptom</dd></dl></div></div><table class="medgenTable"><tbody><tr><td><span class="bold">SNOMED CT: </span></td>
<td>Yellow nails (45342007)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0011367">HP:0011367</a></td></tr>
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">Yellowish discoloration of the nails. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Yellow nails</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/871273" ref="tree=MeSH" title="MedGen record for Abnormality of the integument">Abnormality of the integument</a></span><ul><li><span class="TLline"><a href="/medgen/869100" ref="tree=MeSH" title="MedGen record for Abnormal skin adnexa morphology">Abnormal skin adnexa morphology</a></span><ul><li><span class="TLline"><a href="/medgen/163115" ref="tree=MeSH" title="MedGen record for Abnormal nail morphology">Abnormal nail morphology</a></span><ul><li><span class="TLline"><a href="/medgen/866614" ref="tree=MeSH" title="MedGen record for Abnormality of nail color">Abnormality of nail color</a></span><ul><li><span class="matched_ds">Yellow nails</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_113164"><div><strong>Yellow nail syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>113164</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0221348</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Yellow nail syndrome (YNS) is classically considered to comprise a clinical triad of yellow nails, lymphedema, and respiratory tract involvement. Two of these symptoms are required for the diagnosis, since the complete triad is only observed in about one-third of patients. Onset is usually after puberty (Hoque et al., 2007).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/113164">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_75566"><div><strong>Distichiasis-lymphedema syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>75566</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C0265345</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Lymphedema-distichiasis syndrome (referred to as LDS in this GeneReview) is characterized by lower-limb lymphedema, and distichiasis (aberrant eyelashes ranging from a full set of extra eyelashes to a single hair). Lymphedema typically appears in late childhood or puberty, is confined to the lower limbs with or without involvement of the external genitalia, and is often asymmetric; severity varies within families. Males develop edema at an earlier age and have more problems with cellulitis than females. Distichiasis, which may be present at birth, is observed in 94% of affected individuals. About 75% of affected individuals have ocular findings including corneal irritation, recurrent conjunctivitis, and photophobia; other common findings include varicose veins and ptosis.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/75566">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_419717"><div><strong>Palmoplantar keratoderma i, striate, focal, or diffuse</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>419717</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C2931122</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Striate palmoplantar keratoderma belongs to a group of skin diseases in which there is thickening of the skin on the palms and soles. The striate form is characterized by longitudinal hyperkeratotic lesions extending the length of each finger to the palm, and hyperkeratotic lesions are restricted to regions of the body where pressure and abrasion are greatest (summary by Hunt et al., 2001). Patients with diffuse or focal forms of keratoderma associated with mutation in the DSG1 gene have also been reported (Keren et al., 2005; Milingou et al., 2006).&#13; Genetic Heterogeneity of Keratosis Palmoplantaris Striata&#13; Type II PPKS (PPKS2; 612908) is caused by mutation in the DSP gene (125647) on chromosome 6.&#13; Type III PPKS (PPKS3; 607654) is caused by mutation in the keratin-1 gene (KRT1; 139350) on chromosome 12q.&#13; For a general phenotypic description and a discussion of genetic heterogeneity of palmoplantar keratoderma (PPK), see epidermolytic PPK (144200).&#13; Nitoiu et al. (2014) reviewed desmosome biology in cardiocutaneous syndromes and inherited skin disease, including discussion of the involvement of the DSG1 and DSP genes.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/419717">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_482833"><div><strong>Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>482833</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3281203</a></dd><dt><span class="dotprefix"></span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
<div class="spaceAbove">Patients with familial cutaneous telangiectasia and cancer syndrome (FCTCS) develop cutaneous telangiectases in infancy with patchy alopecia over areas of affected skin, thinning of the lateral eyebrows, and mild dental and nail anomalies. Affected individuals are at increased risk of developing oropharyngeal cancer, and other malignancies have been reported as well (Tanaka et al., 2012).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/482833">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1648463"><div><strong>Lymphedema praecox</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1648463</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4746631</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Primary lymphedema is caused by anatomic or functional defects in the lymphatic system, resulting in chronic swelling of body parts. There may be accompanying nail and skin changes, such as nail dysplasia or papillomatosis. Onset is usually at birth or in early childhood but can occur later, and the severity is variable (summary by Gordon et al., 2013 and Balboa-Beltran et al., 2014).&#13; For a discussion of the genetic heterogeneity of lymphocytic malformation, see 153100.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1648463">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_75566" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Distichiasis-lymphedema syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_482833" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1648463" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Lymphedema praecox</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_419717" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Palmoplantar keratoderma i, striate, focal, or diffuse</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_113164" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Yellow nail syndrome</a></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/38071959">Yellow Nail Syndrome: Analysis of 23 Consecutive Patients and Effect of Combined Fluconazole-Vitamin-E Treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Benassaia E,
Abba S,
Fourgeaud C,
Mihoubi A,
Vignes S</span><br />
<span class="medgenPMjournal">Dermatology</span>
2024;240(2):343-351.
Epub 2023 Dec 9
doi: 10.1159/000535577.
<span class="bold">PMID: </span><a href="/pubmed/38071959" target="_blank">38071959</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35947390">Botulinum Toxin A for the Treatment of Yellow Nail Syndrome and Palmar Primary Hyperhidrosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Li A,
Sun Q</span><br />
<span class="medgenPMjournal">JAMA Dermatol</span>
2022 Oct 1;158(10):1218-1219.
doi: 10.1001/jamadermatol.2022.2533.
<span class="bold">PMID: </span><a href="/pubmed/35947390" target="_blank">35947390</a></div>
<div class="nl"><a target="_blank" href="/pubmed/7923847">Rhinitis, sinusitis and the yellow nail syndrome: a review of symptoms and response to treatment in 17 patients.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Varney VA,
Cumberworth V,
Sudderick R,
Durham SR,
Mackay IS</span><br />
<span class="medgenPMjournal">Clin Otolaryngol Allied Sci</span>
1994 Jun;19(3):237-40.
doi: 10.1111/j.1365-2273.1994.tb01222.x.
<span class="bold">PMID: </span><a href="/pubmed/7923847" target="_blank">7923847</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22yellow%20nails%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (3)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/38071959">Yellow Nail Syndrome: Analysis of 23 Consecutive Patients and Effect of Combined Fluconazole-Vitamin-E Treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Benassaia E,
Abba S,
Fourgeaud C,
Mihoubi A,
Vignes S</span><br />
<span class="medgenPMjournal">Dermatology</span>
2024;240(2):343-351.
Epub 2023 Dec 9
doi: 10.1159/000535577.
<span class="bold">PMID: </span><a href="/pubmed/38071959" target="_blank">38071959</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31603343">Characterization of Sinus Disease in Patients with Yellow Nail Syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gutierrez CN,
Low CM,
Stokken JK,
Choby G,
O'Brien EK</span><br />
<span class="medgenPMjournal">Am J Rhinol Allergy</span>
2020 Mar;34(2):156-161.
Epub 2019 Oct 11
doi: 10.1177/1945892419881253.
<span class="bold">PMID: </span><a href="/pubmed/31603343" target="_blank">31603343</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31589812">Sinonasal mucosal vasculature in yellow nail syndrome and chronic rhinosinusitis with or without polyps.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chatzopoulos K,
Gutierrez CN,
Garcia JJ,
Stokken JK,
Choby G,
O'Brien EK</span><br />
<span class="medgenPMjournal">Int Forum Allergy Rhinol</span>
2020 Jan;10(1):128-132.
Epub 2019 Oct 7
doi: 10.1002/alr.22446.
<span class="bold">PMID: </span><a href="/pubmed/31589812" target="_blank">31589812</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30111321">Effectiveness of clarithromycin in patients with yellow nail syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Matsubayashi S,
Suzuki M,
Suzuki T,
Shiozawa A,
Kobayashi K,
Ishii S,
Iikura M,
Izumi S,
Kudo K,
Sugiyama H</span><br />
<span class="medgenPMjournal">BMC Pulm Med</span>
2018 Aug 15;18(1):138.
doi: 10.1186/s12890-018-0707-4.
<span class="bold">PMID: </span><a href="/pubmed/30111321" target="_blank">30111321</a><a href="/pmc/articles/PMC6094584" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/10807848">Yellow nail syndrome: resolution of yellow nails after successful treatment of breast cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Iqbal M,
Rossoff LJ,
Marzouk KA,
Steinberg HN</span><br />
<span class="medgenPMjournal">Chest</span>
2000 May;117(5):1516-8.
doi: 10.1378/chest.117.5.1516.
<span class="bold">PMID: </span><a href="/pubmed/10807848" target="_blank">10807848</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Yellow%20nails%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/34147420">Yellow nails syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Robles Marhuenda Á,
Molina Collada J,
Arnalich Fernández F</span><br />
<span class="medgenPMjournal">Rev Clin Esp (Barc)</span>
2021 Oct;221(8):491-492.
Epub 2021 Jun 17
doi: 10.1016/j.rceng.2019.07.020.
<span class="bold">PMID: </span><a href="/pubmed/34147420" target="_blank">34147420</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33030243">Yellow nails syndrome: complete triad.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">López Alba A,
Blanco Echevarría A</span><br />
<span class="medgenPMjournal">Med J Aust</span>
2020 Nov;213(9):407-407.e1.
Epub 2020 Oct 8
doi: 10.5694/mja2.50807.
<span class="bold">PMID: </span><a href="/pubmed/33030243" target="_blank">33030243</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32370857">Yellow Nails.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Shakshouk H,
Lehman JS</span><br />
<span class="medgenPMjournal">Mayo Clin Proc</span>
2020 May;95(5):966-967.
doi: 10.1016/j.mayocp.2020.01.037.
<span class="bold">PMID: </span><a href="/pubmed/32370857" target="_blank">32370857</a></div>
<div class="nl"><a target="_blank" href="/pubmed/20103019">Yellow nails, chronic cough, and edema.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Simon RW,
Bundi B</span><br />
<span class="medgenPMjournal">Am J Med</span>
2010 Feb;123(2):125-6.
doi: 10.1016/j.amjmed.2009.10.007.
<span class="bold">PMID: </span><a href="/pubmed/20103019" target="_blank">20103019</a></div>
<div class="nl"><a target="_blank" href="/pubmed/14149160">YELLOW NAILS AND LYMPHOEDEMA.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">HISCOCK C,
ISDALE IC</span><br />
<span class="medgenPMjournal">Lancet</span>
1964 Jun 13;1(7346):1313-4.
<span class="bold">PMID: </span><a href="/pubmed/14149160" target="_blank">14149160</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Yellow%20nails%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (35)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/35947390">Botulinum Toxin A for the Treatment of Yellow Nail Syndrome and Palmar Primary Hyperhidrosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Li A,
Sun Q</span><br />
<span class="medgenPMjournal">JAMA Dermatol</span>
2022 Oct 1;158(10):1218-1219.
doi: 10.1001/jamadermatol.2022.2533.
<span class="bold">PMID: </span><a href="/pubmed/35947390" target="_blank">35947390</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27551950">Bronchiectasis in yellow nail syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Woodfield G,
Nisbet M,
Jacob J,
Mok W,
Loebinger MR,
Hansell DM,
Wells AU,
Wilson R</span><br />
<span class="medgenPMjournal">Respirology</span>
2017 Jan;22(1):101-107.
Epub 2016 Aug 23
doi: 10.1111/resp.12866.
<span class="bold">PMID: </span><a href="/pubmed/27551950" target="_blank">27551950</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21510012">Yellow nail syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Al Hawsawi K,
Pope E</span><br />
<span class="medgenPMjournal">Pediatr Dermatol</span>
2010 Nov-Dec;27(6):675-6.
doi: 10.1111/j.1525-1470.2010.01338.x.
<span class="bold">PMID: </span><a href="/pubmed/21510012" target="_blank">21510012</a></div>
<div class="nl"><a target="_blank" href="/pubmed/10364711">Yellow nails and minimal change nephrotic syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yáñez S,
Val-Bernal JF,
Fernández-Llaca H</span><br />
<span class="medgenPMjournal">Nephron</span>
1999 Jun;82(2):180-2.
doi: 10.1159/000045395.
<span class="bold">PMID: </span><a href="/pubmed/10364711" target="_blank">10364711</a></div>
<div class="nl"><a target="_blank" href="/pubmed/4989238">Generalized lymphoedema with yellow nails, pleural effusions, and macroglobulinemia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">D'Souza MF,
Mahon WE</span><br />
<span class="medgenPMjournal">Proc R Soc Med</span>
1970 May;63(5):456.
<span class="bold">PMID: </span><a href="/pubmed/4989238" target="_blank">4989238</a><a href="/pmc/articles/PMC1811839" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Yellow%20nails%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (25)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/34461002">Yellow Nail Syndrome: A Case Presentation and a Review of Management Options.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Abdalla A,
Jamous F</span><br />
<span class="medgenPMjournal">S D Med</span>
2021 Aug;74(8):368-371.
<span class="bold">PMID: </span><a href="/pubmed/34461002" target="_blank">34461002</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22416910">Yellow nail syndrome: treatment of lymphedema using low pressure compression.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Polat AK,
Dang HT,
Soran A</span><br />
<span class="medgenPMjournal">Lymphat Res Biol</span>
2012 Mar;10(1):30-2.
Epub 2012 Mar 14
doi: 10.1089/lrb.2011.0012.
<span class="bold">PMID: </span><a href="/pubmed/22416910" target="_blank">22416910</a></div>
<div class="nl"><a target="_blank" href="/pubmed/18403655">Yellow nail syndrome: analysis of 41 consecutive patients.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Maldonado F,
Tazelaar HD,
Wang CW,
Ryu JH</span><br />
<span class="medgenPMjournal">Chest</span>
2008 Aug;134(2):375-381.
Epub 2008 Apr 10
doi: 10.1378/chest.08-0137.
<span class="bold">PMID: </span><a href="/pubmed/18403655" target="_blank">18403655</a></div>
<div class="nl"><a target="_blank" href="/pubmed/10807848">Yellow nail syndrome: resolution of yellow nails after successful treatment of breast cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Iqbal M,
Rossoff LJ,
Marzouk KA,
Steinberg HN</span><br />
<span class="medgenPMjournal">Chest</span>
2000 May;117(5):1516-8.
doi: 10.1378/chest.117.5.1516.
<span class="bold">PMID: </span><a href="/pubmed/10807848" target="_blank">10807848</a></div>
<div class="nl"><a target="_blank" href="/pubmed/3962735">Yellow nail syndrome--the triad of yellow nails, lymphedema and pleural effusions. A review of the literature and a case report.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Nordkild P,
Kromann-Andersen H,
Struve-Christensen E</span><br />
<span class="medgenPMjournal">Acta Med Scand</span>
1986;219(2):221-7.
doi: 10.1111/j.0954-6820.1986.tb03302.x.
<span class="bold">PMID: </span><a href="/pubmed/3962735" target="_blank">3962735</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Yellow%20nails%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/30111321">Effectiveness of clarithromycin in patients with yellow nail syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Matsubayashi S,
Suzuki M,
Suzuki T,
Shiozawa A,
Kobayashi K,
Ishii S,
Iikura M,
Izumi S,
Kudo K,
Sugiyama H</span><br />
<span class="medgenPMjournal">BMC Pulm Med</span>
2018 Aug 15;18(1):138.
doi: 10.1186/s12890-018-0707-4.
<span class="bold">PMID: </span><a href="/pubmed/30111321" target="_blank">30111321</a><a href="/pmc/articles/PMC6094584" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27940507">Titanium Dioxide in Toothpaste Causing Yellow Nail Syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hsu TY,
Lin CC,
Lee MD,
Chang BP,
Tsai JD</span><br />
<span class="medgenPMjournal">Pediatrics</span>
2017 Jan;139(1)
Epub 2016 Dec 7
doi: 10.1542/peds.2016-0546.
<span class="bold">PMID: </span><a href="/pubmed/27940507" target="_blank">27940507</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27551950">Bronchiectasis in yellow nail syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Woodfield G,
Nisbet M,
Jacob J,
Mok W,
Loebinger MR,
Hansell DM,
Wells AU,
Wilson R</span><br />
<span class="medgenPMjournal">Respirology</span>
2017 Jan;22(1):101-107.
Epub 2016 Aug 23
doi: 10.1111/resp.12866.
<span class="bold">PMID: </span><a href="/pubmed/27551950" target="_blank">27551950</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19363737">Yellow nails as an adverse reaction to the topical use of 5-fluorouracil for the treatment of nail psoriasis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Fiallo P</span><br />
<span class="medgenPMjournal">J Dermatolog Treat</span>
2009;20(5):299-301.
doi: 10.1080/09546630902773494.
<span class="bold">PMID: </span><a href="/pubmed/19363737" target="_blank">19363737</a></div>
<div class="nl"><a target="_blank" href="/pubmed/1258701">Purpura, pigmentation and yellow nails of the lower extremities in diabetics.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lithner F</span><br />
<span class="medgenPMjournal">Acta Med Scand</span>
1976;199(3):203-8.
doi: 10.1111/j.0954-6820.1976.tb06717.x.
<span class="bold">PMID: </span><a href="/pubmed/1258701" target="_blank">1258701</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Yellow%20nails%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (12)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_104">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/25123563">Characteristics of patients with yellow nail syndrome and pleural effusion.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Valdés L,
Huggins JT,
Gude F,
Ferreiro L,
Alvarez-Dobaño JM,
Golpe A,
Toubes ME,
González-Barcala FJ,
José ES,
Sahn SA</span><br />
<span class="medgenPMjournal">Respirology</span>
2014 Oct;19(7):985-92.
Epub 2014 Aug 14
doi: 10.1111/resp.12357.
<span class="bold">PMID: </span><a href="/pubmed/25123563" target="_blank">25123563</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Yellow%20nails%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div></div>
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet mgSection" id="ID_113">
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Yellow%20nails" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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