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<!--
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UID=357076
|
||
ConceptID=C1866552
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-->
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||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Paragangliomas 2<span class="h1sub">(PPGL2)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>357076</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1866552</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>GLOMUS TUMORS, FAMILIAL, 2; PHEOCHROMOCYTOMA/PARAGANGLIOMA SYNDROME 2; PPGL2; SDHAF2-Related Hereditary Paraganglioma-Pheochromocytoma Syndrome; SDHAF2-Related Hereditary Paraganglioma-Pheochromocytoma Syndrome (Paragangliomas 2)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="SDHAF2 - ID: 54949 - NCBI Gene" href="/gene/54949" class="medgenPMinfo">SDHAF2</a> (11q12.2)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0011121" target="_blank">MONDO:0011121</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/601650" target="_blank">601650</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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||
<div class="portlet mgSection" id="ID_101">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Disease_characteristics">Disease characteristics</h1><a sid="101" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="excerpt">Excerpted from the <i>GeneReview: </i><a href="/books/NBK1548" target="_blank">Hereditary Paraganglioma-Pheochromocytoma Syndromes</a></div><div>Hereditary paraganglioma-pheochromocytoma (PGL/PCC) syndromes are characterized by paragangliomas (tumors that arise from neuroendocrine tissues distributed along the paravertebral axis from the base of the skull to the pelvis) and pheochromocytomas (paragangliomas that are confined to the adrenal medulla). Sympathetic paragangliomas cause catecholamine excess; parasympathetic paragangliomas are most often nonsecretory. Extra-adrenal parasympathetic paragangliomas are located predominantly in the skull base and neck (referred to as head and neck paragangliomas [HNPGLs]) and sometimes in the upper mediastinum; approximately 95% of such tumors are nonsecretory. In contrast, extra-adrenal sympathetic paragangliomas are generally confined to the lower mediastinum, abdomen, and pelvis, and are typically secretory. Pheochromocytomas, which arise from the adrenal medulla, typically lead to catecholamine excess. Symptoms of PGL/PCCs result from either mass effects or catecholamine hypersecretion (e.g., sustained or paroxysmal elevations in blood pressure, headache, episodic profuse sweating, forceful palpitations, pallor, and apprehension or anxiety). The risk for developing metastatic disease is greater for extra-adrenal sympathetic paragangliomas than for pheochromocytomas. Additional tumors reported in individuals with hereditary PGL/PCC syndromes include gastrointestinal stromal tumors (GISTs), pulmonary chondromas, and clear cell renal cell carcinoma. [from <a title="GeneReviews" href="https://www.ncbi.nlm.nih.gov/books/NBK1116" class="defSource" target="_blank">GeneReviews</a>]</div><div class="spaceAbove"><strong>Full text of <i>GeneReview</i> (by section):</strong><br /><a class="medgenPMinfo" href="/books/NBK1548#paragangliomas.Summary" target="NBK1548">Summary</a> | <a class="medgenPMinfo" href="/books/NBK1548#paragangliomas.Diagnosis" target="NBK1548">Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK1548#paragangliomas.Clinical_Characteristics" target="NBK1548">Clinical Characteristics</a> | <a class="medgenPMinfo" href="/books/NBK1548#paragangliomas.Genetically_Related_Allel" target="NBK1548">Genetically Related (Allelic) Disorders</a> | <a class="medgenPMinfo" href="/books/NBK1548#paragangliomas.Differential_Diagnosis" target="NBK1548">Differential Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK1548#paragangliomas.Management" target="NBK1548">Management</a> | <a class="medgenPMinfo" href="/books/NBK1548#paragangliomas.Genetic_Counseling" target="NBK1548">Genetic Counseling</a> | <a class="medgenPMinfo" href="/books/NBK1548#paragangliomas.Resources" target="NBK1548">Resources</a> | <a class="medgenPMinfo" href="/books/NBK1548#paragangliomas.Molecular_Genetics" target="NBK1548">Molecular Genetics</a> | <a class="medgenPMinfo" href="/books/NBK1548#paragangliomas.Chapter_Notes" target="NBK1548">Chapter Notes</a> | <a class="medgenPMinfo" href="/books/NBK1548#paragangliomas.References" target="NBK1548">References</a></div><div class="spaceAbove"><strong>Authors:</strong><br />
|
||
Tobias Else | Samantha Greenberg | Lauren Fishbein <a href="/books/NBK1548" target="NBK1548" title="NCBI Bookshelf: Hereditary Paraganglioma-Pheochromocytoma Syndromes">view full author information</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_117">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Additional_descriptions">Additional descriptions</h1><a sid="117" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="mgSection"><strong>From OMIM</strong><br />Pheochromocytoma/paraganglioma syndrome-2 (PPGL2) is an autosomal dominant disorder characterized by the development of neuroendocrine tumors, usually in adulthood. Paragangliomas are tumors derived from paraganglia located throughout the body. Nonchromaffin types primarily serve as chemoreceptors and are located in the head and neck region (i.e., carotid body, jugular, vagal, and tympanic regions), whereas chromaffin types have endocrine activity, conventionally referred to as 'pheochromocytomas,' and are usually located below the head and neck (i.e., adrenal medulla and pre- and paravertebral thoracoabdominal regions). PPGL can manifest as nonchromaffin head and neck tumors only, adrenal and/or extraadrenal pheochromocytomas only, or a combination of the 2 types of tumors (Baysal, 2002; Neumann et al., 2004).
|
||
For a discussion of genetic heterogeneity of pheochromocytoma/paraganglioma syndrome, see PPGL1 (168000). <a target="_blank" href="http://www.omim.org/entry/601650">http://www.omim.org/entry/601650</a></div><div class="mgSection"><strong>From MedlinePlus Genetics</strong><br />Hereditary paraganglioma-pheochromocytoma is an inherited condition characterized by the growth of tumors in structures called paraganglia. Paraganglia are groups of cells that are found near nerve cell bunches called ganglia. A tumor involving the paraganglia is known as a paraganglioma. A type of paraganglioma known as a pheochromocytoma develops in the adrenal glands, which are located on top of each kidney and produce hormones in response to stress. Other types of paraganglioma are usually found in the head, neck, or trunk. People with hereditary paraganglioma-pheochromocytoma develop one or more paragangliomas, which may include pheochromocytomas.<br /><br />Pheochromocytomas and some other paragangliomas are associated with ganglia of the sympathetic nervous system. The sympathetic nervous system controls the "fight-or-flight" response, a series of changes in the body due to hormones released in response to stress. Sympathetic paragangliomas found outside the adrenal glands, usually in the abdomen, are called extra-adrenal paragangliomas. Most sympathetic paragangliomas, including pheochromocytomas, produce hormones called catecholamines, such as epinephrine (adrenaline) or norepinephrine. These excess catecholamines can cause signs and symptoms such as high blood pressure (hypertension), episodes of rapid heartbeat (palpitations), headaches, or sweating.<br /><br />Most paragangliomas are associated with ganglia of the parasympathetic nervous system, which controls involuntary body functions such as digestion and saliva formation. Parasympathetic paragangliomas, typically found in the head and neck, usually do not produce hormones. However, large tumors may cause signs and symptoms such as coughing, hearing loss in one ear, or difficulty swallowing.<br /><br />Paragangliomas and pheochromocytomas are typically considered an undetermined tumor type, meaning they can be noncancerous (benign) or become cancerous (malignant) and spread to other parts of the body (metastasize). Extra-adrenal paragangliomas become malignant more often than other types of paraganglioma or pheochromocytoma.<br /><br />Paragangliomas and pheochromocytomas can occur in individuals with other inherited disorders, such as von Hippel-Lindau syndrome, Carney-Stratakis syndrome, and certain types of multiple endocrine neoplasia. These other disorders feature additional tumor types and have different genetic causes. Some paragangliomas and pheochromocytomas occur in people with no history of the tumors in their families and appear not to be inherited. These cases are designated as sporadic.<br /><br />Researchers have identified several types of hereditary paraganglioma-pheochromocytoma. Each type is distinguished by its genetic cause. People with types 1, 2, and 3 typically develop paragangliomas in the head or neck region. People with type 4 usually develop extra-adrenal paragangliomas in the abdomen and are at higher risk for malignant tumors that metastasize. The other types are very rare. Hereditary paraganglioma-pheochromocytoma is typically diagnosed in a person's 30s. <a target="_blank" href="https://medlineplus.gov/genetics/condition/hereditary-paraganglioma-pheochromocytoma">https://medlineplus.gov/genetics/condition/hereditary-paraganglioma-pheochromocytoma</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_2853"><div><strong>Carotid body paraganglioma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>2853</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0007279</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
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<div class="spaceAbove">Pheochromocytoma/paraganglioma syndrome-1 (PPGL1) is an autosomal dominant disorder characterized by the development of neuroendocrine tumors, usually in adulthood. Pheochromocytomas arise from chromaffin cells in the adrenal medulla, whereas paragangliomas arise in extra-adrenal sympathetic ganglia in the thorax, abdomen, and pelvis or from parasympathetic paraganglia in the head and neck area (summary by Cascon et al., 2023). Paragangliomas, also referred to as 'glomus body tumors,' are tumors derived from paraganglia located throughout the body. Nonchromaffin types primarily serve as chemoreceptors (hence, the tumor name 'chemodectomas') and are located in the head and neck region (i.e., carotid body, jugular, vagal, and tympanic regions), whereas chromaffin types have endocrine activity, conventionally referred to as 'pheochromocytomas,' and are usually located below the head and neck (i.e., adrenal medulla and pre- and paravertebral thoracoabdominal regions). PPGL can manifest as nonchromaffin head and neck tumors only, adrenal and/or extraadrenal pheochromocytomas only, or a combination of the 2 types of tumors (Baysal, 2002; Neumann et al., 2004). The triad of gastric leiomyosarcoma, pulmonary chondroma, and extraadrenal paraganglioma constitutes a syndrome that occurs mainly in young women and is known as the Carney triad (604287). This triad is not to be confused with the other Carney syndrome of myxoma, spotty pigmentation, and endocrinopathy (160980). Baysal (2008) provided a review of the molecular pathogenesis of hereditary paraganglioma. Genetic Heterogeneity of Pheochromocytoma/Paraganglioma Syndrome See also PPGL2 (601650), caused by mutation in the SDHAF2 gene (613019) on chromosome 11q13; PPGL3 (605373), caused by mutation in the SDHC gene (602413) on chromosome 1q21; PPGL4 (115310), caused by mutation in the SDHB gene (185470) on chromosome 1p36; PPGL5 (614165), caused by mutation in the SDHA gene (600857) on chromosome 5p15; PPGL6 (618464), caused by mutation in the SLC25A11 gene (604165) on chromosome 17p13; and PPGL7 (618475), caused by mutation in the DLST gene (126063) on chromosome 14q24.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/2853">Feature record</a> | <a href="/medgen?term=%22Carotid%20body%20paraganglioma%22%5BClinical%20Features%5D%20OR%202853%5Buid%5D">Search on this feature</a></div></div>
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<div class="divPopper rprt" id="clin_4905"><div><strong>Glomus jugular tumor</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>4905</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0017671</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">An extra-adrenal parasympathetic paraganglioma arising from paraganglia in the base of the skull and middle ear.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/4905">Feature record</a> | <a href="/medgen?term=%22Glomus%20jugular%20tumor%22%5BClinical%20Features%5D%20OR%204905%5Buid%5D">Search on this feature</a></div></div>
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||
<div class="divPopper rprt" id="clin_10294"><div><strong>Neoplasm</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>10294</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0027651</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/10294">Feature record</a> | <a href="/medgen?term=%22Neoplasm%22%5BClinical%20Features%5D%20OR%2010294%5Buid%5D">Search on this feature</a></div></div>
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<div class="divPopper rprt" id="clin_141635"><div><strong>Vagus nerve paraganglioma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>141635</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0474819</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">A tumor that develops in the retrostyloid compartment of the parapharyngeal space, arising from an island of paraganglion tissue derived from the neural crest that is located on the vagus nerve.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/141635">Feature record</a> | <a href="/medgen?term=%22Vagus%20nerve%20paraganglioma%22%5BClinical%20Features%5D%20OR%20141635%5Buid%5D">Search on this feature</a></div></div>
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||
<div class="divPopper rprt" id="clin_105375"><div><strong>Tympanic paraganglioma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>105375</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0474820</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">A middle ear paraganglioma arising from paraganglia around the tympanum. Signs and symptoms include a mass behind the tympanum, tinnitus, and conductive hearing loss.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/105375">Feature record</a> | <a href="/medgen?term=%22Tympanic%20paraganglioma%22%5BClinical%20Features%5D%20OR%20105375%5Buid%5D">Search on this feature</a></div></div>
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||
<div class="divPopper rprt" id="clin_148340"><div><strong>Pulsatile tinnitus</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>148340</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0751559</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Sign or Symptom</dd></dl></div></div></div>
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<div class="spaceAbove">Pulsatile tinnitus is generally classified a kind of objective tinnitus, meaning that it is not only audible to the patient but also to the examiner on auscultation of the auditory canal and/or of surrounding structures with use of an auscultation tube or stethoscope. Usually, pulsatile tinnitus is heard as a lower pitched thumping or booming, a rougher blowing sound which is coincidental with respiration, or as a clicking, higher pitched rhythmic sensation.</div>
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||
<div class="spaceAbove nowrap">See: <a href="/medgen/148340">Feature record</a> | <a href="/medgen?term=%22Pulsatile%20tinnitus%22%5BClinical%20Features%5D%20OR%20148340%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_57717"><div><strong>Cranial nerve paralysis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>57717</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0151311</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Injury to any of the cranial nerves or their nuclei in the brain resulting in muscle weakness.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/57717">Feature record</a> | <a href="/medgen?term=%22Cranial%20nerve%20paralysis%22%5BClinical%20Features%5D%20OR%2057717%5Buid%5D">Search on this feature</a></div></div>
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||
<div class="divPopper rprt" id="clin_2006"><div><strong>Loss of voice</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>2006</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0003564</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Sign or Symptom</dd></dl></div></div></div>
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<div class="spaceAbove">A term referring to the inability to speak. It may result from injuries to the vocal cords or may be functional (psychogenic).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/2006">Feature record</a> | <a href="/medgen?term=%22Loss%20of%20voice%22%5BClinical%20Features%5D%20OR%202006%5Buid%5D">Search on this feature</a></div></div>
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||
<div class="divPopper rprt" id="clin_5602"><div><strong>Hoarse voice</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>5602</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0019825</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Sign or Symptom</dd></dl></div></div></div>
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<div class="spaceAbove">Hoarseness refers to a change in the pitch or quality of the voice, with the voice sounding weak, very breathy, scratchy, or husky.</div>
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||
<div class="spaceAbove nowrap">See: <a href="/medgen/5602">Feature record</a> | <a href="/medgen?term=%22Hoarse%20voice%22%5BClinical%20Features%5D%20OR%205602%5Buid%5D">Search on this feature</a></div></div>
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||
<div class="divPopper rprt" id="clin_53047"><div><strong>Vocal cord paralysis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>53047</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0042928</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">A loss of the ability to move the vocal folds.</div>
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||
<div class="spaceAbove nowrap">See: <a href="/medgen/53047">Feature record</a> | <a href="/medgen?term=%22Vocal%20cord%20paralysis%22%5BClinical%20Features%5D%20OR%2053047%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of the nervous system</span><ul><li class="TLline">
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<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_57717" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cranial nerve paralysis</a></span></li></ul></li><li><span class="TLline">Abnormality of the voice</span><ul><li class="TLline">
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||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_5602" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hoarse voice</a></span></li><li class="TLline">
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||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_2006" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Loss of voice</a></span></li><li class="TLline">
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||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_53047" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Vocal cord paralysis</a></span></li></ul></li><li><span class="TLline">Ear malformation</span><ul><li class="TLline">
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||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_148340" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pulsatile tinnitus</a></span></li></ul></li><li><span class="TLline">Neoplasm</span><ul><li class="TLline">
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||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_2853" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Carotid body paraganglioma</a></span></li><li class="TLline">
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||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_4905" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Glomus jugular tumor</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_10294" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neoplasm</a></span></li><li class="TLline">
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||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_105375" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Tympanic paraganglioma</a></span></li><li class="TLline">
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||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_141635" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Vagus nerve paraganglioma</a></span></li></ul></li></ul></div></div>
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||
</div>
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|
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<div class="portlet mgSection" id="ID_118">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1708353[DISCUI]&test_type=Clinical" ref="ncbi_uid=313270">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1548/" ref="ncbi_uid=313270">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=313270" ref="ncbi_uid=313270">V</a></span></span><span class="TLline"><a href="/medgen/313270" ref="tree=GTR&ncbi_uid=313270&link_uid=313270" title="View MedGen record for 'Hereditary pheochromocytoma-paraganglioma'">Hereditary pheochromocytoma-paraganglioma</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3494181[DISCUI]&test_type=Clinical" ref="ncbi_uid=488134">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=488134" target="_blank" href="/omim/168000">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1548/" ref="ncbi_uid=488134">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=488134" ref="ncbi_uid=488134">V</a></span></span><span class="TLline"><a href="/medgen/488134" ref="tree=GTR&ncbi_uid=488134&link_uid=488134" title="View MedGen record for 'Paragangliomas 1'">Paragangliomas 1</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1868633[DISCUI]&test_type=Clinical" ref="ncbi_uid=358258">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=358258" ref="ncbi_uid=358258">V</a></span></span><span class="TLline"><a href="/medgen/358258" ref="tree=GTR&ncbi_uid=358258&link_uid=358258" title="View MedGen record for 'Paragangliomas with sensorineural hearing loss'">Paragangliomas with sensorineural hearing loss</a></span></li></ul></li><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1866552[DISCUI]&test_type=Clinical" ref="ncbi_uid=357076">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=357076" target="_blank" href="/omim/601650">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1548/" ref="ncbi_uid=357076">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=357076" ref="ncbi_uid=357076">V</a></span></span><span class="TLline">Paragangliomas 2</span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1854336[DISCUI]&test_type=Clinical" ref="ncbi_uid=340200">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=340200" target="_blank" href="/omim/602413">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1548/" ref="ncbi_uid=340200">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=340200" ref="ncbi_uid=340200">V</a></span></span><span class="TLline"><a href="/medgen/340200" ref="tree=GTR&ncbi_uid=340200&link_uid=340200" title="View MedGen record for 'Paragangliomas 3'">Paragangliomas 3</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1861848[DISCUI]&test_type=Clinical" ref="ncbi_uid=349380">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=349380" target="_blank" href="/omim/115310">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1548/" ref="ncbi_uid=349380">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=349380" ref="ncbi_uid=349380">V</a></span></span><span class="TLline"><a href="/medgen/349380" ref="tree=GTR&ncbi_uid=349380&link_uid=349380" title="View MedGen record for 'Paragangliomas 4'">Paragangliomas 4</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3279992[DISCUI]&test_type=Clinical" ref="ncbi_uid=481622">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=481622" target="_blank" href="/omim/600857">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1548/" ref="ncbi_uid=481622">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=481622" ref="ncbi_uid=481622">V</a></span></span><span class="TLline"><a href="/medgen/481622" ref="tree=GTR&ncbi_uid=481622&link_uid=481622" title="View MedGen record for 'Paragangliomas 5'">Paragangliomas 5</a></span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/4043" ref="tree=MeSH" title="MedGen record for Disorder of endocrine system">Disorder of endocrine system</a></span><ul><li><span class="TLline"><a href="/medgen/272569" ref="tree=MeSH" title="MedGen record for Endocrine Syndrome">Endocrine Syndrome</a></span><ul><li><span class="TLline"><a href="/medgen/313270" ref="tree=MeSH" title="MedGen record for Hereditary pheochromocytoma-paraganglioma">Hereditary pheochromocytoma-paraganglioma</a></span><ul><li><span class="matched_ds">Paragangliomas 2</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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</div>
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<div class="portlet mgSection" id="ID_105">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/27570419">Management of gastric and duodenal neuroendocrine tumors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sato Y,
|
||
Hashimoto S,
|
||
Mizuno K,
|
||
Takeuchi M,
|
||
Terai S</span><br />
|
||
<span class="medgenPMjournal">World J Gastroenterol</span>
|
||
2016 Aug 14;22(30):6817-28.
|
||
doi: 10.3748/wjg.v22.i30.6817.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27570419" target="_blank">27570419</a><a href="/pmc/articles/PMC4974581" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27179981">Management of Carotid Bifurcation Tumors: 30-Year Experience.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Torrealba JI,
|
||
Valdés F,
|
||
Krämer AH,
|
||
Mertens R,
|
||
Bergoeing M,
|
||
Mariné L</span><br />
|
||
<span class="medgenPMjournal">Ann Vasc Surg</span>
|
||
2016 Jul;34:200-5.
|
||
Epub 2016 May 12
|
||
doi: 10.1016/j.avsg.2015.12.029.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27179981" target="_blank">27179981</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15051000">Surgical management of hereditary pheochromocytoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yip L,
|
||
Lee JE,
|
||
Shapiro SE,
|
||
Waguespack SG,
|
||
Sherman SI,
|
||
Hoff AO,
|
||
Gagel RF,
|
||
Arens JF,
|
||
Evans DB</span><br />
|
||
<span class="medgenPMjournal">J Am Coll Surg</span>
|
||
2004 Apr;198(4):525-34; discussion 534-5.
|
||
doi: 10.1016/j.jamcollsurg.2003.12.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15051000" target="_blank">15051000</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22paragangliomas%202%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (3)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/neuroendocrine.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35290759">Paragangliomas da Cabeça e Pescoço: A Experiência de um Centro Oncológico do Sul da Europa.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Castelhano L,
|
||
Correia F,
|
||
Donato S,
|
||
Ferreira L,
|
||
Montalvão P,
|
||
Magalhães M</span><br />
|
||
<span class="medgenPMjournal">Acta Med Port</span>
|
||
2022 Nov 2;35(11):789-797.
|
||
Epub 2022 Mar 15
|
||
doi: 10.20344/amp.17185.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35290759" target="_blank">35290759</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27179981">Management of Carotid Bifurcation Tumors: 30-Year Experience.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Torrealba JI,
|
||
Valdés F,
|
||
Krämer AH,
|
||
Mertens R,
|
||
Bergoeing M,
|
||
Mariné L</span><br />
|
||
<span class="medgenPMjournal">Ann Vasc Surg</span>
|
||
2016 Jul;34:200-5.
|
||
Epub 2016 May 12
|
||
doi: 10.1016/j.avsg.2015.12.029.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27179981" target="_blank">27179981</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23913591">Genetics of hereditary head and neck paragangliomas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Boedeker CC,
|
||
Hensen EF,
|
||
Neumann HP,
|
||
Maier W,
|
||
van Nederveen FH,
|
||
Suárez C,
|
||
Kunst HP,
|
||
Rodrigo JP,
|
||
Takes RP,
|
||
Pellitteri PK,
|
||
Rinaldo A,
|
||
Ferlito A</span><br />
|
||
<span class="medgenPMjournal">Head Neck</span>
|
||
2014 Jun;36(6):907-16.
|
||
Epub 2013 Nov 30
|
||
doi: 10.1002/hed.23436.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23913591" target="_blank">23913591</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17409756">Paragangliomas of the head and neck.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Işik AC,
|
||
Imamoğlu M,
|
||
Erem C,
|
||
Sari A</span><br />
|
||
<span class="medgenPMjournal">Med Princ Pract</span>
|
||
2007;16(3):209-14.
|
||
doi: 10.1159/000100392.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17409756" target="_blank">17409756</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2820286">Apudomas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nakano PH,
|
||
Bloom RR,
|
||
Brown BC,
|
||
Gray SW,
|
||
Skandalakis JE,
|
||
Kibbe JM</span><br />
|
||
<span class="medgenPMjournal">Am Surg</span>
|
||
1987 Sep;53(9):505-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2820286" target="_blank">2820286</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Paragangliomas%202%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (10)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35290759">Paragangliomas da Cabeça e Pescoço: A Experiência de um Centro Oncológico do Sul da Europa.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Castelhano L,
|
||
Correia F,
|
||
Donato S,
|
||
Ferreira L,
|
||
Montalvão P,
|
||
Magalhães M</span><br />
|
||
<span class="medgenPMjournal">Acta Med Port</span>
|
||
2022 Nov 2;35(11):789-797.
|
||
Epub 2022 Mar 15
|
||
doi: 10.20344/amp.17185.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35290759" target="_blank">35290759</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27570419">Management of gastric and duodenal neuroendocrine tumors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sato Y,
|
||
Hashimoto S,
|
||
Mizuno K,
|
||
Takeuchi M,
|
||
Terai S</span><br />
|
||
<span class="medgenPMjournal">World J Gastroenterol</span>
|
||
2016 Aug 14;22(30):6817-28.
|
||
doi: 10.3748/wjg.v22.i30.6817.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27570419" target="_blank">27570419</a><a href="/pmc/articles/PMC4974581" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23913591">Genetics of hereditary head and neck paragangliomas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Boedeker CC,
|
||
Hensen EF,
|
||
Neumann HP,
|
||
Maier W,
|
||
van Nederveen FH,
|
||
Suárez C,
|
||
Kunst HP,
|
||
Rodrigo JP,
|
||
Takes RP,
|
||
Pellitteri PK,
|
||
Rinaldo A,
|
||
Ferlito A</span><br />
|
||
<span class="medgenPMjournal">Head Neck</span>
|
||
2014 Jun;36(6):907-16.
|
||
Epub 2013 Nov 30
|
||
doi: 10.1002/hed.23436.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23913591" target="_blank">23913591</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17409756">Paragangliomas of the head and neck.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Işik AC,
|
||
Imamoğlu M,
|
||
Erem C,
|
||
Sari A</span><br />
|
||
<span class="medgenPMjournal">Med Princ Pract</span>
|
||
2007;16(3):209-14.
|
||
doi: 10.1159/000100392.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17409756" target="_blank">17409756</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15290072">CT and MR imaging of unusual locations of extra-adrenal paragangliomas (pheochromocytomas).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sahdev A,
|
||
Sohaib A,
|
||
Monson JP,
|
||
Grossman AB,
|
||
Chew SL,
|
||
Reznek RH</span><br />
|
||
<span class="medgenPMjournal">Eur Radiol</span>
|
||
2005 Jan;15(1):85-92.
|
||
Epub 2004 Jul 28
|
||
doi: 10.1007/s00330-004-2412-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15290072" target="_blank">15290072</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Paragangliomas%202%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (10)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/27179981">Management of Carotid Bifurcation Tumors: 30-Year Experience.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Torrealba JI,
|
||
Valdés F,
|
||
Krämer AH,
|
||
Mertens R,
|
||
Bergoeing M,
|
||
Mariné L</span><br />
|
||
<span class="medgenPMjournal">Ann Vasc Surg</span>
|
||
2016 Jul;34:200-5.
|
||
Epub 2016 May 12
|
||
doi: 10.1016/j.avsg.2015.12.029.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27179981" target="_blank">27179981</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9002742">Meta-[131I]iodobenzylguanidine in the scintigraphic evaluation of neural crest tumors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zagar I,
|
||
Han R,
|
||
Mitrovic S</span><br />
|
||
<span class="medgenPMjournal">Q J Nucl Med</span>
|
||
1995 Dec;39(4 Suppl 1):13-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9002742" target="_blank">9002742</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Paragangliomas%202%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/17409756">Paragangliomas of the head and neck.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Işik AC,
|
||
Imamoğlu M,
|
||
Erem C,
|
||
Sari A</span><br />
|
||
<span class="medgenPMjournal">Med Princ Pract</span>
|
||
2007;16(3):209-14.
|
||
doi: 10.1159/000100392.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17409756" target="_blank">17409756</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9002742">Meta-[131I]iodobenzylguanidine in the scintigraphic evaluation of neural crest tumors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zagar I,
|
||
Han R,
|
||
Mitrovic S</span><br />
|
||
<span class="medgenPMjournal">Q J Nucl Med</span>
|
||
1995 Dec;39(4 Suppl 1):13-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9002742" target="_blank">9002742</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7511316">Ki-67 immunoreactivity in human central nervous system tumors: a study with MIB 1 monoclonal antibody on archival material.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Karamitopoulou E,
|
||
Perentes E,
|
||
Diamantis I,
|
||
Maraziotis T</span><br />
|
||
<span class="medgenPMjournal">Acta Neuropathol</span>
|
||
1994;87(1):47-54.
|
||
doi: 10.1007/BF00386253.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7511316" target="_blank">7511316</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7681617">Proliferating cell nuclear antigen immunoreactivity in human central nervous system neoplasms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Karamitopoulou E,
|
||
Perentes E,
|
||
Melachrinou M,
|
||
Maraziotis T</span><br />
|
||
<span class="medgenPMjournal">Acta Neuropathol</span>
|
||
1993;85(3):316-22.
|
||
doi: 10.1007/BF00227728.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7681617" target="_blank">7681617</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Paragangliomas%202%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/31843064">Targeted Radionuclide Therapy: A Historical and Personal Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Goldsmith SJ</span><br />
|
||
<span class="medgenPMjournal">Semin Nucl Med</span>
|
||
2020 Jan;50(1):87-97.
|
||
Epub 2019 Nov 6
|
||
doi: 10.1053/j.semnuclmed.2019.07.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31843064" target="_blank">31843064</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27929599">Surgical management of parapharyngeal space tumors: The role of cervical and lateral skull base approaches.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Poletti AM,
|
||
Dubey SP,
|
||
Colombo G,
|
||
Cugini G</span><br />
|
||
<span class="medgenPMjournal">Ear Nose Throat J</span>
|
||
2016 Dec;95(12):E1-E6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27929599" target="_blank">27929599</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27179981">Management of Carotid Bifurcation Tumors: 30-Year Experience.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Torrealba JI,
|
||
Valdés F,
|
||
Krämer AH,
|
||
Mertens R,
|
||
Bergoeing M,
|
||
Mariné L</span><br />
|
||
<span class="medgenPMjournal">Ann Vasc Surg</span>
|
||
2016 Jul;34:200-5.
|
||
Epub 2016 May 12
|
||
doi: 10.1016/j.avsg.2015.12.029.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27179981" target="_blank">27179981</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25563310">Clinical and genetic investigation of a multi-generational Chinese family afflicted with Von Hippel-Lindau disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang J,
|
||
Ma J,
|
||
Du X,
|
||
Wu D,
|
||
Ai H,
|
||
Bai J,
|
||
Dong S,
|
||
Yang Q,
|
||
Qu K,
|
||
Lyu Y,
|
||
Valenzuela RK,
|
||
Liu C</span><br />
|
||
<span class="medgenPMjournal">Chin Med J (Engl)</span>
|
||
2015 Jan 5;128(1):32-8.
|
||
doi: 10.4103/0366-6999.147802.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25563310" target="_blank">25563310</a><a href="/pmc/articles/PMC4837816" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3003308">Gastrin releasing peptide in human neuroendocrine tumours.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bostwick DG,
|
||
Bensch KG</span><br />
|
||
<span class="medgenPMjournal">J Pathol</span>
|
||
1985 Dec;147(4):237-44.
|
||
doi: 10.1002/path.1711470402.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3003308" target="_blank">3003308</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Paragangliomas%202%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
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||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
|
||
<div class="rightCol mgCol">
|
||
<div class="portlet mgSection" id="ID_113">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul id="my-toc"></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_106">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C1866552%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (37)</a></li>
|
||
<li><a href="/gtr/tests?term=C1866552%5bDISCUI%5d&filter=method%3A2%5F30" target="_blank">RNA analysis (2)</a></li>
|
||
<li><a href="/gtr/tests?term=C1866552%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (4)</a></li>
|
||
<li><a href="/gtr/tests?term=C1866552%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (42)</a></li>
|
||
<li><a href="/gtr/tests?term=C1866552%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (4)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C1866552%5bDISCUI%5d" target="_blank">See all (48)</a></total></li>
|
||
</ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_119">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=601650" target="_blank">OMIM</a></li><li><a href="https://clinicaltrials.gov/search?cond=Paragangliomas%202" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_121">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22paragangliomas%202%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nccn.org/professionals/physician_gls/pdf/neuroendocrine.pdf">NCCN, 2023</a><div>NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023</div></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_115">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Molecular_resources">Molecular resources</h1><a sid="115" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=613019" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=54949[geneid]" target="_blank">View SDHAF2 variations in ClinVar</a></li><li><a href="/nuccore/300863138" target="_blank">RefSeqGene</a></li><li><a href="https://catalog.coriell.org/Search?q=601650" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_116">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Consumer_resources">Consumer resources</h1><a sid="116" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="http://www.diseaseinfosearch.org/Paragangliomas+2/5579" target="_blank">Genetic Alliance</a></li><li><a href="https://www.malacards.org/card/pheochromocytoma_paraganglioma_syndrome_2" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Paragangliomas%202" target="_blank">MedlinePlus</a></li><li><a href="https://medlineplus.gov/genetics/condition/hereditary-paraganglioma-pheochromocytoma" target="_blank">MedlinePlusGenetics (GHR)</a></li><li><a href="https://rarediseases.info.nih.gov/diseases/10544/disease" target="_blank">NCATS Office of Rare Diseases Research (GARD)</a></li></ul></div>
|
||
</div>
|
||
</div>
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Reviews</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Reviews" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="/pubmed/20301715" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=3" target="_blank"><span class="gene_reviews">GeneReviews</span></a>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/clinical?term=Paragangliomas%202" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=3" target="_blank">PubMed Clinical Queries</a>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed?term=Paragangliomas%202%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=3&linkpostotal=3" target="_blank">Reviews in PubMed</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<!-- MedGen supplemental column ends here -->
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content DiscoveryDbLinks">
|
||
<ul>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=357076" ref="log$=recordlinks">ClinVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gene?LinkName=medgen_gene_diseases&from_uid=357076" ref="log$=recordlinks">Gene</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in NCBI Gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C1866552[DISCUI]" ref="log$=recordlinks">GTR</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C1866552[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/mesh?LinkName=medgen_mesh&from_uid=357076" ref="log$=recordlinks">MeSH</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related Medical Subject Headings</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/books?LinkName=medgen_books&from_uid=357076" ref="log$=recordlinks">NCBI Bookshelf</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in NCBI Bookshelf</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim&from_uid=357076" ref="log$=recordlinks">OMIM</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related records in OMIM</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim_gene&from_uid=357076" ref="log$=recordlinks">OMIM(Genes)</a>
|
||
<div class="brieflinkpop offscreen_noflow">OMIM records containing genes associated with phenotypes registered in MedGen</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=medgen_pmc&from_uid=357076" ref="log$=recordlinks">PMC Articles</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in PubMed Central Links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed&from_uid=357076" ref="log$=recordlinks">PubMed</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed_bookshelf_cited&from_uid=357076" ref="log$=recordlinks">PubMed (Bookshelf cited)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Links to PubMed based on citations in GeneReviews and Medical Genetics Summaries</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed_genereviews&from_uid=357076" ref="log$=recordlinks">PubMed (GeneReviews)</a>
|
||
<div class="brieflinkpop offscreen_noflow">GeneReviews in PubMed</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed_omim&from_uid=357076" ref="log$=recordlinks">PubMed (OMIM)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="portlet">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Recent activity</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Shutter"></a>
|
||
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|
||
<div class="portlet_content">
|
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<div id="HTDisplay" class="">
|
||
<input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Cmd" sid="1" type="hidden" />
|
||
<div class="action">
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory">
|
||
Clear
|
||
</a>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOn" cmd="HTOff" href="?cmd=HTOff&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle">
|
||
Turn Off
|
||
</a>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" sid="2" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOff" cmd="HTOn" href="?cmd=HTOn&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle">
|
||
Turn On
|
||
</a>
|
||
</div>
|
||
<ul id="activity">
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67d443d72f30673f7b52a6ce">Paragangliomas 2</a>
|
||
<div class="ralinkpop offscreen_noflow">Paragangliomas 2<div class="brieflinkpopdesc"></div></div>
|
||
<div class="tertiary">MedGen</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67d4438684f3725e5992ea92">Hereditary Paraganglioma-Pheochromocytoma Syndromes - GeneReviews®</a>
|
||
<div class="ralinkpop offscreen_noflow">Hereditary Paraganglioma-Pheochromocytoma Syndromes - GeneReviews®<div class="brieflinkpopdesc"></div></div>
|
||
<div class="tertiary"></div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67d4438267c23b31e00af90d">SDHAF2 succinate dehydrogenase complex assembly factor 2 [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">SDHAF2 succinate dehydrogenase complex assembly factor 2 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:54949</div></div>
|
||
<div class="tertiary">Gene</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67d443802f30673f7b509900">Homo sapiens succinate dehydrogenase complex assembly factor 2 (SDHAF2), mRNA; n...</a>
|
||
<div class="ralinkpop offscreen_noflow">Homo sapiens succinate dehydrogenase complex assembly factor 2 (SDHAF2), mRNA; nuclear gene for mitochondrial product<div class="brieflinkpopdesc">gi|1779948864|ref|NM_017841.4|</div></div>
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