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<!--
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UID=341396
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ConceptID=C1849172
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Hypoplasia of the frontal lobes</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>341396</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1849172</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Frontal lobe hypoplasia; Hypoplastic frontal lobes</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0007333">HP:0007333</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Underdevelopment of the frontal lobe of the cerebrum. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
||
</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Hypoplasia of the frontal lobes</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/105425" ref="tree=MeSH" title="MedGen record for Abnormality of the nervous system">Abnormality of the nervous system</a></span><ul><li><span class="TLline"><a href="/medgen/868416" ref="tree=MeSH" title="MedGen record for Abnormal nervous system morphology">Abnormal nervous system morphology</a></span><ul><li><span class="TLline"><a href="/medgen/892343" ref="tree=MeSH" title="MedGen record for Morphological central nervous system abnormality">Morphological central nervous system abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/871188" ref="tree=MeSH" title="MedGen record for Aplasia/Hypoplasia involving the central nervous system">Aplasia/Hypoplasia involving the central nervous system</a></span><ul><li><span class="TLline"><a href="/medgen/870456" ref="tree=MeSH" title="MedGen record for Aplasia/Hypoplasia of the cerebrum">Aplasia/Hypoplasia of the cerebrum</a></span><ul><li><span class="TLline"><a href="/medgen/343321" ref="tree=MeSH" title="MedGen record for Cerebral hypoplasia">Cerebral hypoplasia</a></span><ul><li><span class="matched_ds">Hypoplasia of the frontal lobes</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
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||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_61231"><div><strong>Smith-Lemli-Opitz syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>61231</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0175694</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Smith-Lemli-Opitz syndrome (SLOS) is a congenital multiple-anomaly / cognitive impairment syndrome caused by an abnormality in cholesterol metabolism resulting from deficiency of the enzyme 7-dehydrocholesterol (7-DHC) reductase. It is characterized by prenatal and postnatal growth restriction, microcephaly, moderate-to-severe intellectual disability, and multiple major and minor malformations. The malformations include distinctive facial features, cleft palate, cardiac defects, underdeveloped external genitalia in males, postaxial polydactyly, and 2-3 syndactyly of the toes. The clinical spectrum is wide; individuals with normal development and only minor malformations have been described.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/61231">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_266149"><div><strong>Cardio-facio-cutaneous syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>266149</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1275081</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Cardiofaciocutaneous (CFC) syndrome is characterized by cardiac abnormalities (pulmonic stenosis and other valve dysplasias, septal defects, hypertrophic cardiomyopathy, rhythm disturbances), distinctive craniofacial appearance, and cutaneous abnormalities (including xerosis, hyperkeratosis, ichthyosis, keratosis pilaris, ulerythema ophryogenes, eczema, pigmented moles, hemangiomas, and palmoplantar hyperkeratosis). The hair is typically sparse, curly, fine or thick, and woolly or brittle; eyelashes and eyebrows may be absent or sparse. Nails may be dystrophic or fast growing. Affected individuals typically have some form of neurologic and/or cognitive delay (ranging from mild to severe). Most individuals have severe feeding issues, which can contribute to poor growth, and many require nasogastric or gastrostomy tube feeding. Many affected individuals have eye findings, including strabismus, nystagmus, refractive errors, and optic nerve hypoplasia. Seizures may be present and can be refractory to therapy.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/266149">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_375581"><div><strong>Developmental and epileptic encephalopathy, 8</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>375581</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1845102</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Developmental and epileptic encephalopathy-8 (DEE8) is an X-linked disorder characterized by seizure onset before 2 years of age and severe developmental delay. Some patients have hyperekplexia (summary by Shimojima et al., 2011). For general phenotypic descriptions and discussions of genetic heterogeneity of developmental and epileptic encephalopathy and hyperekplexia, see DEE1 (308350) and HKPX1 (149400), respectively.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/375581">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_341818"><div><strong>Yunis-Varon syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>341818</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1857663</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Yunis-Varon syndrome (YVS) is a severe autosomal recessive disorder characterized by skeletal defects, including cleidocranial dysplasia and digital anomalies, and severe neurologic involvement with neuronal loss. Enlarged cytoplasmic vacuoles are found in neurons, muscle, and cartilage. The disorder is usually lethal in infancy (summary by Campeau et al., 2013).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/341818">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_347149"><div><strong>Osteodysplastic primordial dwarfism, type 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>347149</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1859452</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">RNU4atac-opathy encompasses the phenotypic spectrum of biallelic RNU4ATAC pathogenic variants, including the three historically designated clinical phenotypes microcephalic osteodysplastic primordial dwarfism type I/III (MOPDI), Roifman syndrome, and Lowry-Wood syndrome, as well as varying combinations of the disease features / system involvement that do not match specific defined phenotypes. Findings present in all affected individuals include growth restriction, microcephaly, skeletal dysplasia, and cognitive impairment. Less common but variable findings include brain anomalies, seizures, strokes, immunodeficiency, and cardiac anomalies, as well as ophthalmologic, skin, renal, gastrointestinal, hearing, and endocrine involvement.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/347149">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_409857"><div><strong>Intellectual disability, autosomal dominant 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>409857</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1969562</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Mental or Behavioral Dysfunction</dd></dl></div></div></div>
|
||
<div class="spaceAbove">MBD5 haploinsufficiency is a neurodevelopmental disorder characterized by developmental delay, intellectual disability, severe speech impairment, seizures, sleep disturbances, and abnormal behaviors. Most children lack speech entirely or have single words, short phrases, or short sentences. Seizures are present in more than 80% of children; onset is usually around age two years. Sleep disturbances, present in about 90%, can result in excessive daytime drowsiness. Abnormal behaviors can include autistic-like behaviors (80%) and self-injury and aggression (>60%).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/409857">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_462055"><div><strong>Rett syndrome, congenital variant</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462055</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3150705</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">FOXG1 syndrome is characterized by moderate-to-profound developmental delay and intellectual disability, postnatal growth deficiency, congenital or postnatal microcephaly, hyperkinetic/dyskinetic movement disorder, hypotonia, neurobehavioral/psychiatric manifestations (motor stereotypies, impairment of social interaction, abnormal sleep patterns, unexplained episodes of crying, restlessness, and bruxism), feeding difficulties with poor weight gain, strabismus, seizures, spasticity, gastroesophageal reflux, and aspiration. Some individuals have cortical visual impairment, kyphosis, scoliosis, and/or abnormal breathing. Characteristic neuroimaging findings include corpus callosum anomalies (especially a marked, filiform thinning of the rostrum of the corpus callosum), a simplified gyral pattern, and hyperplasia of the fornices.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462055">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_266149" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cardio-facio-cutaneous syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_375581" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Developmental and epileptic encephalopathy, 8</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_409857" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Intellectual disability, autosomal dominant 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_347149" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Osteodysplastic primordial dwarfism, type 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462055" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Rett syndrome, congenital variant</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_61231" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Smith-Lemli-Opitz syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_341818" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Yunis-Varon syndrome</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35219263">TMS for the functional evaluation of cannabis effects and for treatment of cannabis addiction: A review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nardone R,
|
||
Sebastianelli L,
|
||
Versace V,
|
||
Ferrazzoli D,
|
||
Brigo F,
|
||
Schwenker K,
|
||
Saltuari L,
|
||
Trinka E</span><br />
|
||
<span class="medgenPMjournal">Psychiatry Res</span>
|
||
2022 Apr;310:114431.
|
||
Epub 2022 Feb 5
|
||
doi: 10.1016/j.psychres.2022.114431.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35219263" target="_blank">35219263</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31983023">Pharmacological Management of the Genetic Generalised Epilepsies in Adolescents and Adults.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stephen LJ,
|
||
Brodie MJ</span><br />
|
||
<span class="medgenPMjournal">CNS Drugs</span>
|
||
2020 Feb;34(2):147-161.
|
||
doi: 10.1007/s40263-020-00698-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31983023" target="_blank">31983023</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20230934">The value of neuronavigated rTMS for the treatment of depression.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schönfeldt-Lecuona C,
|
||
Lefaucheur JP,
|
||
Cardenas-Morales L,
|
||
Wolf RC,
|
||
Kammer T,
|
||
Herwig U</span><br />
|
||
<span class="medgenPMjournal">Neurophysiol Clin</span>
|
||
2010 Mar;40(1):37-43.
|
||
Epub 2009 Jul 16
|
||
doi: 10.1016/j.neucli.2009.06.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20230934" target="_blank">20230934</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(hypoplasia%20of%20the%20frontal%20lobes)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (83)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39039061">The mediating effect of the amygdala-frontal circuit on the association between depressive symptoms and cognitive function in Alzheimer's disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Du Y,
|
||
Zhang S,
|
||
Qiu Q,
|
||
Fang Y,
|
||
Zhao L,
|
||
Yue L,
|
||
Wang J,
|
||
Yan F,
|
||
Li X</span><br />
|
||
<span class="medgenPMjournal">Transl Psychiatry</span>
|
||
2024 Jul 23;14(1):301.
|
||
doi: 10.1038/s41398-024-03026-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39039061" target="_blank">39039061</a><a href="/pmc/articles/PMC11263372" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27137745">Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schmaal L,
|
||
Hibar DP,
|
||
Sämann PG,
|
||
Hall GB,
|
||
Baune BT,
|
||
Jahanshad N,
|
||
Cheung JW,
|
||
van Erp TGM,
|
||
Bos D,
|
||
Ikram MA,
|
||
Vernooij MW,
|
||
Niessen WJ,
|
||
Tiemeier H,
|
||
Hofman A,
|
||
Wittfeld K,
|
||
Grabe HJ,
|
||
Janowitz D,
|
||
Bülow R,
|
||
Selonke M,
|
||
Völzke H,
|
||
Grotegerd D,
|
||
Dannlowski U,
|
||
Arolt V,
|
||
Opel N,
|
||
Heindel W,
|
||
Kugel H,
|
||
Hoehn D,
|
||
Czisch M,
|
||
Couvy-Duchesne B,
|
||
Rentería ME,
|
||
Strike LT,
|
||
Wright MJ,
|
||
Mills NT,
|
||
de Zubicaray GI,
|
||
McMahon KL,
|
||
Medland SE,
|
||
Martin NG,
|
||
Gillespie NA,
|
||
Goya-Maldonado R,
|
||
Gruber O,
|
||
Krämer B,
|
||
Hatton SN,
|
||
Lagopoulos J,
|
||
Hickie IB,
|
||
Frodl T,
|
||
Carballedo A,
|
||
Frey EM,
|
||
van Velzen LS,
|
||
Penninx BWJH,
|
||
van Tol MJ,
|
||
van der Wee NJ,
|
||
Davey CG,
|
||
Harrison BJ,
|
||
Mwangi B,
|
||
Cao B,
|
||
Soares JC,
|
||
Veer IM,
|
||
Walter H,
|
||
Schoepf D,
|
||
Zurowski B,
|
||
Konrad C,
|
||
Schramm E,
|
||
Normann C,
|
||
Schnell K,
|
||
Sacchet MD,
|
||
Gotlib IH,
|
||
MacQueen GM,
|
||
Godlewska BR,
|
||
Nickson T,
|
||
McIntosh AM,
|
||
Papmeyer M,
|
||
Whalley HC,
|
||
Hall J,
|
||
Sussmann JE,
|
||
Li M,
|
||
Walter M,
|
||
Aftanas L,
|
||
Brack I,
|
||
Bokhan NA,
|
||
Thompson PM,
|
||
Veltman DJ</span><br />
|
||
<span class="medgenPMjournal">Mol Psychiatry</span>
|
||
2017 Jun;22(6):900-909.
|
||
Epub 2016 May 3
|
||
doi: 10.1038/mp.2016.60.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27137745" target="_blank">27137745</a><a href="/pmc/articles/PMC5444023" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26143154">Development of the uncinate fasciculus: Implications for theory and developmental disorders.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Olson IR,
|
||
Von Der Heide RJ,
|
||
Alm KH,
|
||
Vyas G</span><br />
|
||
<span class="medgenPMjournal">Dev Cogn Neurosci</span>
|
||
2015 Aug;14:50-61.
|
||
Epub 2015 Jun 23
|
||
doi: 10.1016/j.dcn.2015.06.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26143154" target="_blank">26143154</a><a href="/pmc/articles/PMC4795006" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23611351">Neuroimaging in frontotemporal dementia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rohrer JD,
|
||
Rosen HJ</span><br />
|
||
<span class="medgenPMjournal">Int Rev Psychiatry</span>
|
||
2013 Apr;25(2):221-9.
|
||
doi: 10.3109/09540261.2013.778822.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23611351" target="_blank">23611351</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21614001">Transcriptomic analysis of autistic brain reveals convergent molecular pathology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Voineagu I,
|
||
Wang X,
|
||
Johnston P,
|
||
Lowe JK,
|
||
Tian Y,
|
||
Horvath S,
|
||
Mill J,
|
||
Cantor RM,
|
||
Blencowe BJ,
|
||
Geschwind DH</span><br />
|
||
<span class="medgenPMjournal">Nature</span>
|
||
2011 May 25;474(7351):380-4.
|
||
doi: 10.1038/nature10110.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21614001" target="_blank">21614001</a><a href="/pmc/articles/PMC3607626" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypoplasia%20of%20the%20frontal%20lobes%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2600)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36174274">Evidence that the frontal pole has a significant role in the pathophysiology of schizophrenia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Snelleksz M,
|
||
Rossell SL,
|
||
Gibbons A,
|
||
Nithianantharajah J,
|
||
Dean B</span><br />
|
||
<span class="medgenPMjournal">Psychiatry Res</span>
|
||
2022 Nov;317:114850.
|
||
Epub 2022 Sep 13
|
||
doi: 10.1016/j.psychres.2022.114850.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36174274" target="_blank">36174274</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23932763">The olfactory system.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Leboucq N,
|
||
Menjot de Champfleur N,
|
||
Menjot de Champfleur S,
|
||
Bonafé A</span><br />
|
||
<span class="medgenPMjournal">Diagn Interv Imaging</span>
|
||
2013 Oct;94(10):985-91.
|
||
Epub 2013 Aug 7
|
||
doi: 10.1016/j.diii.2013.06.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23932763" target="_blank">23932763</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23611351">Neuroimaging in frontotemporal dementia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rohrer JD,
|
||
Rosen HJ</span><br />
|
||
<span class="medgenPMjournal">Int Rev Psychiatry</span>
|
||
2013 Apr;25(2):221-9.
|
||
doi: 10.3109/09540261.2013.778822.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23611351" target="_blank">23611351</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9569338">Middle interhemispheric fusion.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Coll Masfarré S,
|
||
Majós Torró C,
|
||
Aguilera Grijalvo C,
|
||
Pons Irazazábal LC</span><br />
|
||
<span class="medgenPMjournal">Eur Radiol</span>
|
||
1998;8(4):631-3.
|
||
doi: 10.1007/s003300050450.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9569338" target="_blank">9569338</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9252791">Frontotemporal dementia: its rediscovery.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pasquier F,
|
||
Petit H</span><br />
|
||
<span class="medgenPMjournal">Eur Neurol</span>
|
||
1997;38(1):1-6.
|
||
doi: 10.1159/000112894.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9252791" target="_blank">9252791</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypoplasia%20of%20the%20frontal%20lobes%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2215)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37865032">Neural mechanisms of working memory dysfunction in patients with chronic insomnia disorder.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yang L,
|
||
Xiao X,
|
||
Yu L,
|
||
Shen Z,
|
||
Luo Y,
|
||
Zhao G,
|
||
Dou Z,
|
||
Lin W,
|
||
Yang J,
|
||
Yang L,
|
||
Yu S</span><br />
|
||
<span class="medgenPMjournal">Sleep Med</span>
|
||
2023 Dec;112:151-158.
|
||
Epub 2023 Oct 12
|
||
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<div class="nl"><a target="_blank" href="/pubmed/25861700">Depressive Rumination, the Default-Mode Network, and the Dark Matter of Clinical Neuroscience.</a></div>
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Farmer M,
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<div class="nl"><a target="_blank" href="/pubmed/25843917">The role of frontal EEG asymmetry in post-traumatic stress disorder.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Meyer T,
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Smeets T,
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Giesbrecht T,
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Quaedflieg CW,
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Smulders FT,
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<div class="portlet_content ln"><span class="medgenPMauthor">Honig LS,
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Bell K,
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Chin SS</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/12844524" target="_blank">12844524</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypoplasia%20of%20the%20frontal%20lobes%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (910)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/25843917">The role of frontal EEG asymmetry in post-traumatic stress disorder.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Meyer T,
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Smeets T,
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Giesbrecht T,
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Quaedflieg CW,
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Smulders FT,
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</div>
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<div class="portlet mgSection" id="ID_104">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">
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<div class="nl"><a target="_blank" href="/pubmed/36930208">Posterior Cingulate Epilepsy: A Systematic Review.</a></div>
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||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31476712">Structural, functional, and neurochemical neuroimaging of methamphetamine-associated psychosis: A systematic review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Chen C,
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Hsu FC,
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<span class="bold">PMID: </span><a href="/pubmed/31476712" target="_blank">31476712</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22729418">The involvement of the orbitofrontal cortex in psychiatric disorders: an update of neuroimaging findings.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jackowski AP,
|
||
Araújo Filho GM,
|
||
Almeida AG,
|
||
Araújo CM,
|
||
Reis M,
|
||
Nery F,
|
||
Batista IR,
|
||
Silva I,
|
||
Lacerda AL</span><br />
|
||
<span class="medgenPMjournal">Braz J Psychiatry</span>
|
||
2012 Jun;34(2):207-12.
|
||
doi: 10.1590/s1516-44462012000200014.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22729418" target="_blank">22729418</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20085668">A systematic review of the effects of antipsychotic drugs on brain volume.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Moncrieff J,
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Leo J</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/20085668" target="_blank">20085668</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypoplasia%20of%20the%20frontal%20lobes%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (57)</a></div></div>
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|
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(hypoplasia%20of%20the%20frontal%20lobes)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Hypoplasia%20of%20the%20frontal%20lobes%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
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<p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br />
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