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<!--
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||
UID=337668
|
||
ConceptID=C1846865
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Substantia nigra gliosis</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>337668</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1846865</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Gliosis in the substantia nigra</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0011960">HP:0011960</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Focal proliferation of glial cells in the substantia nigra. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
||
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||
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Substantia nigra gliosis</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/105425" ref="tree=MeSH" title="MedGen record for Abnormality of the nervous system">Abnormality of the nervous system</a></span><ul><li><span class="TLline"><a href="/medgen/868416" ref="tree=MeSH" title="MedGen record for Abnormal nervous system morphology">Abnormal nervous system morphology</a></span><ul><li><span class="TLline"><a href="/medgen/892343" ref="tree=MeSH" title="MedGen record for Morphological central nervous system abnormality">Morphological central nervous system abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/866738" ref="tree=MeSH" title="MedGen record for Abnormal brain morphology">Abnormal brain morphology</a></span><ul><li><span class="TLline"><a href="/medgen/867390" ref="tree=MeSH" title="MedGen record for Abnormal midbrain morphology">Abnormal midbrain morphology</a></span><ul><li><span class="TLline"><a href="/medgen/868012" ref="tree=MeSH" title="MedGen record for Abnormal substantia nigra morphology">Abnormal substantia nigra morphology</a></span><ul><li><span class="matched_ds">Substantia nigra gliosis</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_339628"><div><strong>Autosomal dominant Parkinson disease 8</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>339628</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1846862</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">LRRK2 Parkinson disease (PD) is characterized by features consistent with idiopathic PD: initial motor features of slowly progressive asymmetric tremor at rest and/or bradykinesia, cogwheel muscle rigidity, postural instability, and gait abnormalities that may include festination and freezing. Certain nonmotor symptoms in LRRK2-PD, especially REM sleep behavior disorder and cognitive decline, may occur at similar or slightly reduced frequency compared to typical idiopathic* PD. Onset is generally after age 50, although early-onset (in the 20s) and late-onset (in the 90s) disease has been described. * Idiopathic PD refers to the presence of signs and symptoms of PD for which the etiology is currently unknown and in which there is no known family history of PD.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/339628">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_338883"><div><strong>Dementia/parkinsonism with non-Alzheimer amyloid plaques</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>338883</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1852223</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/338883">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_401500"><div><strong>Autosomal recessive juvenile Parkinson disease 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>401500</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C1868675</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Parkin type of early-onset Parkinson disease (PARK-Parkin) is characterized by the cardinal signs of Parkinson disease (PD): bradykinesia, resting tremor, and rigidity. The median age at onset is 31 years (range: 3-81 years). The disease is slowly progressive: disease duration of more than 50 years has been reported. Clinical findings vary; hyperreflexia is common. Lower-limb dystonia may be a presenting sign and cognitive decline appears to be no more frequent than in the general population. Dyskinesia as a result of treatment with levodopa frequently occurs.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/401500">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_463618"><div><strong>Parkinson disease, late-onset</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>463618</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3160718</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Gaucher disease (GD) encompasses a continuum of clinical findings from a perinatal-lethal disorder to an asymptomatic type. The characterization of three major clinical types (1, 2, and 3) and two clinical forms (perinatal-lethal and cardiovascular) is useful in determining prognosis and management. Cardiopulmonary complications have been described with all the clinical phenotypes, although varying in frequency and severity. Type 1 GD is characterized by the presence of clinical or radiographic evidence of bone disease (osteopenia, focal lytic or sclerotic lesions, and osteonecrosis), hepatosplenomegaly, anemia, thrombocytopenia, lung disease, and the absence of primary central nervous system disease. Type 2 GD is characterized by primary central nervous system disease with onset before age two years, limited psychomotor development, and a rapidly progressive course with death by age two to four years. Type 3 GD is characterized by primary central nervous system disease with childhood onset, a more slowly progressive course, and survival into the third or fourth decade. The perinatal-lethal form is associated with ichthyosiform or collodion skin abnormalities or with nonimmune hydrops fetalis. The cardiovascular form is characterized by calcification of the aortic and mitral valves, mild splenomegaly, corneal opacities, and supranuclear ophthalmoplegia.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/463618">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_339628" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal dominant Parkinson disease 8</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_401500" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal recessive juvenile Parkinson disease 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_338883" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dementia/parkinsonism with non-Alzheimer amyloid plaques</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_463618" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Parkinson disease, late-onset</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39832321">Progressive supranuclear palsy: an updated approach on diagnosis, treatment, risk factors and outlook in Mexico.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gómez-Virgilio L,
|
||
Gutiérrez-Malacara AI,
|
||
Rivera-Osorio J,
|
||
Silva-Lucero MDC,
|
||
Padilla-Mendoza JR,
|
||
Gómez-Ramírez DE,
|
||
Cárdenas-Aguayo MDC</span><br />
|
||
<span class="medgenPMjournal">Gac Med Mex</span>
|
||
2024;160(4):374-383.
|
||
doi: 10.24875/GMM.M24000930.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39832321" target="_blank">39832321</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32024799">APOE genotype regulates pathology and disease progression in synucleinopathy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Davis AA,
|
||
Inman CE,
|
||
Wargel ZM,
|
||
Dube U,
|
||
Freeberg BM,
|
||
Galluppi A,
|
||
Haines JN,
|
||
Dhavale DD,
|
||
Miller R,
|
||
Choudhury FA,
|
||
Sullivan PM,
|
||
Cruchaga C,
|
||
Perlmutter JS,
|
||
Ulrich JD,
|
||
Benitez BA,
|
||
Kotzbauer PT,
|
||
Holtzman DM</span><br />
|
||
<span class="medgenPMjournal">Sci Transl Med</span>
|
||
2020 Feb 5;12(529)
|
||
doi: 10.1126/scitranslmed.aay3069.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32024799" target="_blank">32024799</a><a href="/pmc/articles/PMC7289511" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15197700">Clinicopathological investigation of vascular parkinsonism, including clinical criteria for diagnosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zijlmans JC,
|
||
Daniel SE,
|
||
Hughes AJ,
|
||
Révész T,
|
||
Lees AJ</span><br />
|
||
<span class="medgenPMjournal">Mov Disord</span>
|
||
2004 Jun;19(6):630-40.
|
||
doi: 10.1002/mds.20083.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15197700" target="_blank">15197700</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(substantia%20nigra%20gliosis)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (4)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38303548">The SATB1-MIR22-GBA axis mediates glucocerebroside accumulation inducing a cellular senescence-like phenotype in dopaminergic neurons.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Russo T,
|
||
Kolisnyk B,
|
||
B S A,
|
||
Plessis-Belair J,
|
||
Kim TW,
|
||
Martin J,
|
||
Ni J,
|
||
Pearson JA,
|
||
Park EJ,
|
||
Sher RB,
|
||
Studer L,
|
||
Riessland M</span><br />
|
||
<span class="medgenPMjournal">Aging Cell</span>
|
||
2024 Apr;23(4):e14077.
|
||
Epub 2024 Feb 1
|
||
doi: 10.1111/acel.14077.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38303548" target="_blank">38303548</a><a href="/pmc/articles/PMC11019121" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36598274">Susceptibility Magnetic Resonance Imaging Correlates with Glial Density and Tau in the Substantia Nigra Pars Compacta.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang EW,
|
||
Brown GL,
|
||
Lewis MM,
|
||
Jellen LC,
|
||
Pu C,
|
||
Johnson ML,
|
||
Chen H,
|
||
Kong L,
|
||
Du G,
|
||
Huang X</span><br />
|
||
<span class="medgenPMjournal">Mov Disord</span>
|
||
2023 Mar;38(3):464-473.
|
||
Epub 2023 Jan 4
|
||
doi: 10.1002/mds.29311.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36598274" target="_blank">36598274</a><a href="/pmc/articles/PMC10445152" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32024799">APOE genotype regulates pathology and disease progression in synucleinopathy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Davis AA,
|
||
Inman CE,
|
||
Wargel ZM,
|
||
Dube U,
|
||
Freeberg BM,
|
||
Galluppi A,
|
||
Haines JN,
|
||
Dhavale DD,
|
||
Miller R,
|
||
Choudhury FA,
|
||
Sullivan PM,
|
||
Cruchaga C,
|
||
Perlmutter JS,
|
||
Ulrich JD,
|
||
Benitez BA,
|
||
Kotzbauer PT,
|
||
Holtzman DM</span><br />
|
||
<span class="medgenPMjournal">Sci Transl Med</span>
|
||
2020 Feb 5;12(529)
|
||
doi: 10.1126/scitranslmed.aay3069.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32024799" target="_blank">32024799</a><a href="/pmc/articles/PMC7289511" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17493041">Progressive supranuclear palsy: pathology and genetics.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dickson DW,
|
||
Rademakers R,
|
||
Hutton ML</span><br />
|
||
<span class="medgenPMjournal">Brain Pathol</span>
|
||
2007 Jan;17(1):74-82.
|
||
doi: 10.1111/j.1750-3639.2007.00054.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17493041" target="_blank">17493041</a><a href="/pmc/articles/PMC8095545" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15136696">Autosomal dominant parkinsonism associated with variable synuclein and tau pathology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wszolek ZK,
|
||
Pfeiffer RF,
|
||
Tsuboi Y,
|
||
Uitti RJ,
|
||
McComb RD,
|
||
Stoessl AJ,
|
||
Strongosky AJ,
|
||
Zimprich A,
|
||
Müller-Myhsok B,
|
||
Farrer MJ,
|
||
Gasser T,
|
||
Calne DB,
|
||
Dickson DW</span><br />
|
||
<span class="medgenPMjournal">Neurology</span>
|
||
2004 May 11;62(9):1619-22.
|
||
doi: 10.1212/01.wnl.0000125015.06989.db.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15136696" target="_blank">15136696</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Substantia%20nigra%20gliosis%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (44)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33988462">Emerging targets for the diagnosis of Parkinson's disease: examination of systemic biomarkers.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cheslow L,
|
||
Snook AE,
|
||
Waldman SA</span><br />
|
||
<span class="medgenPMjournal">Biomark Med</span>
|
||
2021 Jun;15(8):597-608.
|
||
Epub 2021 May 14
|
||
doi: 10.2217/bmm-2020-0654.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33988462" target="_blank">33988462</a><a href="/pmc/articles/PMC8293030" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22908195">Parkinson's disease and parkinsonism: neuropathology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dickson DW</span><br />
|
||
<span class="medgenPMjournal">Cold Spring Harb Perspect Med</span>
|
||
2012 Aug 1;2(8)
|
||
doi: 10.1101/cshperspect.a009258.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22908195" target="_blank">22908195</a><a href="/pmc/articles/PMC3405828" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15136696">Autosomal dominant parkinsonism associated with variable synuclein and tau pathology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wszolek ZK,
|
||
Pfeiffer RF,
|
||
Tsuboi Y,
|
||
Uitti RJ,
|
||
McComb RD,
|
||
Stoessl AJ,
|
||
Strongosky AJ,
|
||
Zimprich A,
|
||
Müller-Myhsok B,
|
||
Farrer MJ,
|
||
Gasser T,
|
||
Calne DB,
|
||
Dickson DW</span><br />
|
||
<span class="medgenPMjournal">Neurology</span>
|
||
2004 May 11;62(9):1619-22.
|
||
doi: 10.1212/01.wnl.0000125015.06989.db.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15136696" target="_blank">15136696</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7582051">Multiple system atrophy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Quinn N,
|
||
Wenning G</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Neurol</span>
|
||
1995 Aug;8(4):323-6.
|
||
doi: 10.1097/00019052-199508000-00013.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7582051" target="_blank">7582051</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1350062">Postvaccinal parkinsonism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Alves RS,
|
||
Barbosa ER,
|
||
Scaff M</span><br />
|
||
<span class="medgenPMjournal">Mov Disord</span>
|
||
1992;7(2):178-80.
|
||
doi: 10.1002/mds.870070213.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1350062" target="_blank">1350062</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Substantia%20nigra%20gliosis%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (86)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/28784297">The 200-year journey of Parkinson disease: Reflecting on the past and looking towards the future.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fahn S</span><br />
|
||
<span class="medgenPMjournal">Parkinsonism Relat Disord</span>
|
||
2018 Jan;46 Suppl 1:S1-S5.
|
||
Epub 2017 Aug 1
|
||
doi: 10.1016/j.parkreldis.2017.07.020.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28784297" target="_blank">28784297</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9629847">Hereditary form of parkinsonism--dementia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Muenter MD,
|
||
Forno LS,
|
||
Hornykiewicz O,
|
||
Kish SJ,
|
||
Maraganore DM,
|
||
Caselli RJ,
|
||
Okazaki H,
|
||
Howard FM Jr,
|
||
Snow BJ,
|
||
Calne DB</span><br />
|
||
<span class="medgenPMjournal">Ann Neurol</span>
|
||
1998 Jun;43(6):768-81.
|
||
doi: 10.1002/ana.410430612.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9629847" target="_blank">9629847</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1469445">Dopa-responsive dystonia with depigmentation of the substantia nigra and formation of Lewy bodies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Olsson JE,
|
||
Brunk U,
|
||
Lindvall B,
|
||
Eeg-Olofsson O</span><br />
|
||
<span class="medgenPMjournal">J Neurol Sci</span>
|
||
1992 Oct;112(1-2):90-5.
|
||
doi: 10.1016/0022-510x(92)90137-a.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1469445" target="_blank">1469445</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1350062">Postvaccinal parkinsonism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Alves RS,
|
||
Barbosa ER,
|
||
Scaff M</span><br />
|
||
<span class="medgenPMjournal">Mov Disord</span>
|
||
1992;7(2):178-80.
|
||
doi: 10.1002/mds.870070213.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1350062" target="_blank">1350062</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3970282">Iron pigment in the brain of a man with tardive dyskinesia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Campbell WG,
|
||
Raskind MA,
|
||
Gordon T,
|
||
Shaw CM</span><br />
|
||
<span class="medgenPMjournal">Am J Psychiatry</span>
|
||
1985 Mar;142(3):364-5.
|
||
doi: 10.1176/ajp.142.3.364.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3970282" target="_blank">3970282</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Substantia%20nigra%20gliosis%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (35)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/25968946">Antagonistic pleiotropic effects of nitric oxide in the pathophysiology of Parkinson's disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tripathy D,
|
||
Chakraborty J,
|
||
Mohanakumar KP</span><br />
|
||
<span class="medgenPMjournal">Free Radic Res</span>
|
||
2015;49(9):1129-39.
|
||
Epub 2015 Jun 4
|
||
doi: 10.3109/10715762.2015.1045505.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25968946" target="_blank">25968946</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15136696">Autosomal dominant parkinsonism associated with variable synuclein and tau pathology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wszolek ZK,
|
||
Pfeiffer RF,
|
||
Tsuboi Y,
|
||
Uitti RJ,
|
||
McComb RD,
|
||
Stoessl AJ,
|
||
Strongosky AJ,
|
||
Zimprich A,
|
||
Müller-Myhsok B,
|
||
Farrer MJ,
|
||
Gasser T,
|
||
Calne DB,
|
||
Dickson DW</span><br />
|
||
<span class="medgenPMjournal">Neurology</span>
|
||
2004 May 11;62(9):1619-22.
|
||
doi: 10.1212/01.wnl.0000125015.06989.db.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15136696" target="_blank">15136696</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8558163">Signal changes on MRI and increases in reactive microgliosis, astrogliosis, and iron in the putamen of two patients with multiple system atrophy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schwarz J,
|
||
Weis S,
|
||
Kraft E,
|
||
Tatsch K,
|
||
Bandmann O,
|
||
Mehraein P,
|
||
Vogl T,
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Oertel WH</span><br />
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1996 Jan;60(1):98-101.
|
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doi: 10.1136/jnnp.60.1.98.
|
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<span class="bold">PMID: </span><a href="/pubmed/8558163" target="_blank">8558163</a><a href="/pmc/articles/PMC486200" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1922131">Parkinsonism and extraocular motor abnormalities with unusual neuropathological findings.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Calabrese VP,
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Hadfield MG</span><br />
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||
<span class="medgenPMjournal">Mov Disord</span>
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1991;6(3):257-60.
|
||
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|
||
<span class="bold">PMID: </span><a href="/pubmed/1922131" target="_blank">1922131</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1865200">Pure akinesia: an atypical manifestation of progressive supranuclear palsy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Matsuo H,
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||
Takashima H,
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||
Kishikawa M,
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Kinoshita I,
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Mori M,
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Tsujihata M,
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1991 May;54(5):397-400.
|
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<span class="bold">PMID: </span><a href="/pubmed/1865200" target="_blank">1865200</a><a href="/pmc/articles/PMC488536" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Substantia%20nigra%20gliosis%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (53)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38303548">The SATB1-MIR22-GBA axis mediates glucocerebroside accumulation inducing a cellular senescence-like phenotype in dopaminergic neurons.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Russo T,
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Kolisnyk B,
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B S A,
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Plessis-Belair J,
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Kim TW,
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Martin J,
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Ni J,
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Pearson JA,
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Park EJ,
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Sher RB,
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||
Studer L,
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||
Riessland M</span><br />
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<span class="medgenPMjournal">Aging Cell</span>
|
||
2024 Apr;23(4):e14077.
|
||
Epub 2024 Feb 1
|
||
doi: 10.1111/acel.14077.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38303548" target="_blank">38303548</a><a href="/pmc/articles/PMC11019121" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35854141">Nigral neuropathology of Parkinson's motor subtypes coincide with circuitopathies: a scoping review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Boonstra JT,
|
||
McGurran H,
|
||
Temel Y,
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||
Jahanshahi A</span><br />
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||
<span class="medgenPMjournal">Brain Struct Funct</span>
|
||
2022 Sep;227(7):2231-2242.
|
||
Epub 2022 Jul 19
|
||
doi: 10.1007/s00429-022-02531-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35854141" target="_blank">35854141</a><a href="/pmc/articles/PMC9418085" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34927205">Motor neuron pathology in CANVAS due to RFC1 expansions.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Huin V,
|
||
Coarelli G,
|
||
Guemy C,
|
||
Boluda S,
|
||
Debs R,
|
||
Mochel F,
|
||
Stojkovic T,
|
||
Grabli D,
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||
Maisonobe T,
|
||
Gaymard B,
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||
Lenglet T,
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||
Tard C,
|
||
Davion JB,
|
||
Sablonnière B,
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||
Monin ML,
|
||
Ewenczyk C,
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||
Viala K,
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||
Charles P,
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||
Le Ber I,
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||
Reilly MM,
|
||
Houlden H,
|
||
Cortese A,
|
||
Seilhean D,
|
||
Brice A,
|
||
Durr A</span><br />
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||
<span class="medgenPMjournal">Brain</span>
|
||
2022 Jun 30;145(6):2121-2132.
|
||
doi: 10.1093/brain/awab449.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34927205" target="_blank">34927205</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25968946">Antagonistic pleiotropic effects of nitric oxide in the pathophysiology of Parkinson's disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tripathy D,
|
||
Chakraborty J,
|
||
Mohanakumar KP</span><br />
|
||
<span class="medgenPMjournal">Free Radic Res</span>
|
||
2015;49(9):1129-39.
|
||
Epub 2015 Jun 4
|
||
doi: 10.3109/10715762.2015.1045505.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25968946" target="_blank">25968946</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18991877">Defining "neuroinflammation".</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">O'Callaghan JP,
|
||
Sriram K,
|
||
Miller DB</span><br />
|
||
<span class="medgenPMjournal">Ann N Y Acad Sci</span>
|
||
2008 Oct;1139:318-30.
|
||
doi: 10.1196/annals.1432.032.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18991877" target="_blank">18991877</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Substantia%20nigra%20gliosis%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (97)</a></div></div>
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|
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|
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<div class="nl"><a target="_blank" href="/pubmed/23114877">Clinicopathological review of pallidonigroluysian atrophy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wong JC,
|
||
Armstrong MJ,
|
||
Lang AE,
|
||
Hazrati LN</span><br />
|
||
<span class="medgenPMjournal">Mov Disord</span>
|
||
2013 Mar;28(3):274-81.
|
||
Epub 2012 Oct 31
|
||
doi: 10.1002/mds.25232.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23114877" target="_blank">23114877</a></div>
|
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Substantia%20nigra%20gliosis%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div></div>
|
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|
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