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<!--
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UID=335001
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ConceptID=C1844666
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Immune dysregulation</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>335001</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1844666</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
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<td>Unregulated immune response</td></tr>
|
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<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0002958">HP:0002958</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">Altered immune function characterized by lymphoid proliferation, immune activation, and excessive autoreactivity often leading to autoimmune/inflammatory complications. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Immune dysregulation</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/867388" ref="tree=MeSH" title="MedGen record for Abnormality of the immune system">Abnormality of the immune system</a></span><ul><li><span class="TLline"><a href="/medgen/869194" ref="tree=MeSH" title="MedGen record for Abnormality of immune system physiology">Abnormality of immune system physiology</a></span><ul><li><span class="matched_ds">Immune dysregulation</span></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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||
</div>
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||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_83339"><div><strong>Insulin-dependent diabetes mellitus secretory diarrhea syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>83339</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0342288</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked) syndrome is characterized by systemic autoimmunity, typically beginning in the first year of life, which includes the triad of enteropathy (manifesting as malabsorption and watery diarrhea), endocrinopathy (most commonly type 1 insulin-dependent diabetes mellitus), and eczematous dermatitis. In addition to these manifestations, many children have other autoimmune phenomena including cytopenias, autoimmune hepatitis, nephropathy, lymphadenopathy, splenomegaly, alopecia, arthritis, and interstitial lung disease related to immune dysregulation. Fetal presentation of IPEX syndrome includes hydrops, echogenic bowel, skin desquamation, intrauterine growth deficiency, and fetal akinesia. Without aggressive immunosuppression or hematopoietic stem cell transplantation (HSCT), the majority of affected males will die within the first one to two years of life from metabolic derangements, severe malabsorption, or sepsis. Individuals with a milder phenotype have survived into the second or third decade of life, but this is uncommon.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/83339">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_375009"><div><strong>Spondyloenchondrodysplasia with immune dysregulation</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>375009</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1842763</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Spondyloenchondrodysplasia with immune dysregulation (SPENCDI) is an immunoosseous dysplasia combining the typical metaphyseal and vertebral bone lesions of spondyloenchondrodysplasia (SPENCD) with immune dysfunction and neurologic involvement. The skeletal dysplasia is characterized by radiolucent and irregular spondylar and metaphyseal lesions that represent islands of chondroid tissue within bone. The vertebral bodies show dorsally accentuated platyspondyly with disturbance of ossification. Clinical abnormalities such as short stature, rhizomelic micromelia, increased lumbar lordosis, barrel chest, facial anomalies, and clumsy movements may be present (Menger et al., 1989). Central nervous system involvement includes spasticity, mental retardation, and cerebral calcifications, and immune dysregulation ranges from autoimmunity to immunodeficiency. Neurologic and autoimmune manifestations have been observed in different combinations within a single family, suggesting that this disorder may be defined by specific radiographic features but has remarkably pleiotropic manifestations (Renella et al., 2006). Briggs et al. (2016) also noted variability in skeletal, neurologic, and immune phenotypes, which was sometimes marked between members of the same family. Classification of the Enchondromatoses In their classification of the enchondromatoses, Spranger et al. (1978) called Ollier disease and Maffucci syndrome types I and II enchondromatosis, respectively; metachondromatosis (156250), type III; and spondyloenchondrodysplasia (SPENCD), also called spondyloenchondromatosis, type IV; enchondromatosis with irregular vertebral lesions, type V; and generalized enchondromatosis, type VI. Halal and Azouz (1991) added 3 tentative categories to the 6 in the classification of Spranger et al. (1978). Pansuriya et al. (2010) suggested a new classification of enchondromatosis (multiple enchondromas).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/375009">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_481620"><div><strong>Autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>481620</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3279990</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">IMD31C is a disorder of immunologic dysregulation with highly variable manifestations resulting from autosomal dominant gain-of-function mutations in STAT1 (600555). Most patients present in infancy or early childhood with chronic mucocutaneous candidiasis (CMC). Other highly variable features include recurrent bacterial, viral, fungal, and mycoplasmal infections, disseminated dimorphic fungal infections, enteropathy with villous atrophy, and autoimmune disorders, such as hypothyroidism or diabetes mellitus. A subset of patients show apparently nonimmunologic features, including osteopenia, delayed puberty, and intracranial aneurysms. Laboratory studies show increased activation of gamma-interferon (IFNG; 147570)-mediated inflammation (summary by Uzel et al., 2013 and Sampaio et al., 2013).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/481620">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_766875"><div><strong>Autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766875</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3553961</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autoinflammation, antibody deficiency, and immune dysregulation (APLAID) is an autosomal dominant systemic disorder characterized by recurrent blistering skin lesions with a dense inflammatory infiltrate and variable involvement of other tissues, including joints, the eye, and the gastrointestinal tract. Affected individuals have a mild humoral immune deficiency associated with recurrent sinopulmonary infections, but no evidence of circulating autoantibodies (summary by Zhou et al., 2012).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/766875">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_767139"><div><strong>Obesity due to leptin receptor gene deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>767139</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3554225</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Leptin receptor deficiency is characterized by severe early-onset obesity, major hyperphagia, hypogonadotropic hypogonadism, and neuroendocrine/metabolic dysfunction (summary by Dehghani et al., 2018).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/767139">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1384124"><div><strong>Severe combined immunodeficiency due to LAT deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1384124</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4479588</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">IMD52 is an autosomal recessive primary immunodeficiency with variable manifestations, including severe combined immunodeficiency, hematologic autoimmune disorders, progressive lymphopenia and hypogammaglobulinemia, and lymphoproliferation with splenomegaly. Patients develop severe recurrent infections from infancy, and most die without bone marrow transplantation. The variable clinical features result from a defect in T-cell receptor signaling (summary by Keller et al., 2016 and Bacchelli et al., 2017).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1384124">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_481620" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_766875" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_83339" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Insulin-dependent diabetes mellitus secretory diarrhea syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_767139" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Obesity due to leptin receptor gene deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1384124" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Severe combined immunodeficiency due to LAT deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_375009" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Spondyloenchondrodysplasia with immune dysregulation</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37866486">Depression in Alzheimer's Disease: Epidemiology, Mechanisms, and Treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Huang YY,
|
||
Gan YH,
|
||
Yang L,
|
||
Cheng W,
|
||
Yu JT</span><br />
|
||
<span class="medgenPMjournal">Biol Psychiatry</span>
|
||
2024 Jun 1;95(11):992-1005.
|
||
Epub 2023 Oct 20
|
||
doi: 10.1016/j.biopsych.2023.10.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37866486" target="_blank">37866486</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37207318">Management of Perianal Crohn's Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Parian AM,
|
||
Obi M,
|
||
Fleshner P,
|
||
Schwartz DA</span><br />
|
||
<span class="medgenPMjournal">Am J Gastroenterol</span>
|
||
2023 Aug 1;118(8):1323-1331.
|
||
Epub 2023 Jun 19
|
||
doi: 10.14309/ajg.0000000000002326.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37207318" target="_blank">37207318</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32412211">Atopic Dermatitis: Diagnosis and Treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Frazier W,
|
||
Bhardwaj N</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2020 May 15;101(10):590-598.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32412211" target="_blank">32412211</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22immune%20dysregulation%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (279)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37951645">Common Variable Immunodeficiency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Remiker A,
|
||
Bolling K,
|
||
Verbsky J</span><br />
|
||
<span class="medgenPMjournal">Med Clin North Am</span>
|
||
2024 Jan;108(1):107-121.
|
||
Epub 2023 Jul 21
|
||
doi: 10.1016/j.mcna.2023.06.012.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37951645" target="_blank">37951645</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35804480">Systemic Lupus Erythematosus: New Diagnostic and Therapeutic Approaches.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lazar S,
|
||
Kahlenberg JM</span><br />
|
||
<span class="medgenPMjournal">Annu Rev Med</span>
|
||
2023 Jan 27;74:339-352.
|
||
Epub 2022 Jul 8
|
||
doi: 10.1146/annurev-med-043021-032611.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35804480" target="_blank">35804480</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34073257">Intricate Connections between the Microbiota and Endometriosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jiang I,
|
||
Yong PJ,
|
||
Allaire C,
|
||
Bedaiwy MA</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2021 May 26;22(11)
|
||
doi: 10.3390/ijms22115644.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34073257" target="_blank">34073257</a><a href="/pmc/articles/PMC8198999" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30092921">Recognizing and Managing Postpartum Psychosis: A Clinical Guide for Obstetric Providers.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Osborne LM</span><br />
|
||
<span class="medgenPMjournal">Obstet Gynecol Clin North Am</span>
|
||
2018 Sep;45(3):455-468.
|
||
doi: 10.1016/j.ogc.2018.04.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30092921" target="_blank">30092921</a><a href="/pmc/articles/PMC6174883" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29910038">Idiopathic nephrotic syndrome in children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Noone DG,
|
||
Iijima K,
|
||
Parekh R</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2018 Jul 7;392(10141):61-74.
|
||
Epub 2018 Jun 14
|
||
doi: 10.1016/S0140-6736(18)30536-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29910038" target="_blank">29910038</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Immune%20dysregulation%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1982)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37215125">Dysregulation of immune response in PCOS organ system.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang J,
|
||
Yin T,
|
||
Liu S</span><br />
|
||
<span class="medgenPMjournal">Front Immunol</span>
|
||
2023;14:1169232.
|
||
Epub 2023 May 5
|
||
doi: 10.3389/fimmu.2023.1169232.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37215125" target="_blank">37215125</a><a href="/pmc/articles/PMC10196194" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35804480">Systemic Lupus Erythematosus: New Diagnostic and Therapeutic Approaches.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lazar S,
|
||
Kahlenberg JM</span><br />
|
||
<span class="medgenPMjournal">Annu Rev Med</span>
|
||
2023 Jan 27;74:339-352.
|
||
Epub 2022 Jul 8
|
||
doi: 10.1146/annurev-med-043021-032611.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35804480" target="_blank">35804480</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36135958">Systemic sclerosis: one year in review 2022.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lepri G,
|
||
Orlandi M,
|
||
Di Battista M,
|
||
De Mattia G,
|
||
Da Rio M,
|
||
Codullo V,
|
||
Guiducci S,
|
||
Della Rossa A</span><br />
|
||
<span class="medgenPMjournal">Clin Exp Rheumatol</span>
|
||
2022 Oct;40(10):1911-1920.
|
||
Epub 2022 Sep 21
|
||
doi: 10.55563/clinexprheumatol/3401fl.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36135958" target="_blank">36135958</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35297082">Differences between pediatric and adult atopic dermatitis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ramírez-Marín HA,
|
||
Silverberg JI</span><br />
|
||
<span class="medgenPMjournal">Pediatr Dermatol</span>
|
||
2022 May;39(3):345-353.
|
||
Epub 2022 Mar 16
|
||
doi: 10.1111/pde.14971.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35297082" target="_blank">35297082</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33463535">Immune dysregulation as a driver of idiopathic pulmonary fibrosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Shenderov K,
|
||
Collins SL,
|
||
Powell JD,
|
||
Horton MR</span><br />
|
||
<span class="medgenPMjournal">J Clin Invest</span>
|
||
2021 Jan 19;131(2)
|
||
doi: 10.1172/JCI143226.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33463535" target="_blank">33463535</a><a href="/pmc/articles/PMC7810481" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Immune%20dysregulation%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1671)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37595484">Dengue overview: An updated systemic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Khan MB,
|
||
Yang ZS,
|
||
Lin CY,
|
||
Hsu MC,
|
||
Urbina AN,
|
||
Assavalapsakul W,
|
||
Wang WH,
|
||
Chen YH,
|
||
Wang SF</span><br />
|
||
<span class="medgenPMjournal">J Infect Public Health</span>
|
||
2023 Oct;16(10):1625-1642.
|
||
Epub 2023 Aug 3
|
||
doi: 10.1016/j.jiph.2023.08.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37595484" target="_blank">37595484</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36516818">The pathogenesis of rheumatoid arthritis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Alivernini S,
|
||
Firestein GS,
|
||
McInnes IB</span><br />
|
||
<span class="medgenPMjournal">Immunity</span>
|
||
2022 Dec 13;55(12):2255-2270.
|
||
doi: 10.1016/j.immuni.2022.11.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36516818" target="_blank">36516818</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35001525">Idiopathic pulmonary fibrosis: Current and future treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Glass DS,
|
||
Grossfeld D,
|
||
Renna HA,
|
||
Agarwala P,
|
||
Spiegler P,
|
||
DeLeon J,
|
||
Reiss AB</span><br />
|
||
<span class="medgenPMjournal">Clin Respir J</span>
|
||
2022 Feb;16(2):84-96.
|
||
Epub 2022 Jan 10
|
||
doi: 10.1111/crj.13466.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35001525" target="_blank">35001525</a><a href="/pmc/articles/PMC9060042" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33463535">Immune dysregulation as a driver of idiopathic pulmonary fibrosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Shenderov K,
|
||
Collins SL,
|
||
Powell JD,
|
||
Horton MR</span><br />
|
||
<span class="medgenPMjournal">J Clin Invest</span>
|
||
2021 Jan 19;131(2)
|
||
doi: 10.1172/JCI143226.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33463535" target="_blank">33463535</a><a href="/pmc/articles/PMC7810481" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29910038">Idiopathic nephrotic syndrome in children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Noone DG,
|
||
Iijima K,
|
||
Parekh R</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2018 Jul 7;392(10141):61-74.
|
||
Epub 2018 Jun 14
|
||
doi: 10.1016/S0140-6736(18)30536-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29910038" target="_blank">29910038</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Immune%20dysregulation%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1218)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36476130">CNS-peripheral immune interactions in hemorrhagic stroke.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Li X,
|
||
Chen G</span><br />
|
||
<span class="medgenPMjournal">J Cereb Blood Flow Metab</span>
|
||
2023 Feb;43(2):185-197.
|
||
Epub 2022 Dec 7
|
||
doi: 10.1177/0271678X221145089.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36476130" target="_blank">36476130</a><a href="/pmc/articles/PMC9903219" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36028143">The immunology of the post-cardiac arrest syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cunningham CA,
|
||
Coppler PJ,
|
||
Skolnik AB</span><br />
|
||
<span class="medgenPMjournal">Resuscitation</span>
|
||
2022 Oct;179:116-123.
|
||
Epub 2022 Aug 24
|
||
doi: 10.1016/j.resuscitation.2022.08.013.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36028143" target="_blank">36028143</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34073257">Intricate Connections between the Microbiota and Endometriosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jiang I,
|
||
Yong PJ,
|
||
Allaire C,
|
||
Bedaiwy MA</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2021 May 26;22(11)
|
||
doi: 10.3390/ijms22115644.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34073257" target="_blank">34073257</a><a href="/pmc/articles/PMC8198999" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30596219">Hepatosplenic T-Cell Lymphomas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gowda L,
|
||
Foss F</span><br />
|
||
<span class="medgenPMjournal">Cancer Treat Res</span>
|
||
2019;176:185-193.
|
||
doi: 10.1007/978-3-319-99716-2_9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30596219" target="_blank">30596219</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29910038">Idiopathic nephrotic syndrome in children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Noone DG,
|
||
Iijima K,
|
||
Parekh R</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2018 Jul 7;392(10141):61-74.
|
||
Epub 2018 Jun 14
|
||
doi: 10.1016/S0140-6736(18)30536-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29910038" target="_blank">29910038</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Immune%20dysregulation%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1046)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37207318">Management of Perianal Crohn's Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Parian AM,
|
||
Obi M,
|
||
Fleshner P,
|
||
Schwartz DA</span><br />
|
||
<span class="medgenPMjournal">Am J Gastroenterol</span>
|
||
2023 Aug 1;118(8):1323-1331.
|
||
Epub 2023 Jun 19
|
||
doi: 10.14309/ajg.0000000000002326.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37207318" target="_blank">37207318</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34073257">Intricate Connections between the Microbiota and Endometriosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jiang I,
|
||
Yong PJ,
|
||
Allaire C,
|
||
Bedaiwy MA</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2021 May 26;22(11)
|
||
doi: 10.3390/ijms22115644.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34073257" target="_blank">34073257</a><a href="/pmc/articles/PMC8198999" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33631651">Clinical disease activity and flare in SLE: Current concepts and novel biomarkers.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Thanou A,
|
||
Jupe E,
|
||
Purushothaman M,
|
||
Niewold TB,
|
||
Munroe ME</span><br />
|
||
<span class="medgenPMjournal">J Autoimmun</span>
|
||
2021 May;119:102615.
|
||
Epub 2021 Feb 22
|
||
doi: 10.1016/j.jaut.2021.102615.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33631651" target="_blank">33631651</a><a href="/pmc/articles/PMC8044029" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28541437">Hyperferritinemia and inflammation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kernan KF,
|
||
Carcillo JA</span><br />
|
||
<span class="medgenPMjournal">Int Immunol</span>
|
||
2017 Nov 1;29(9):401-409.
|
||
doi: 10.1093/intimm/dxx031.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28541437" target="_blank">28541437</a><a href="/pmc/articles/PMC5890889" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26837712">Acute-on-chronic liver failure: terminology, mechanisms and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sarin SK,
|
||
Choudhury A</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Gastroenterol Hepatol</span>
|
||
2016 Mar;13(3):131-49.
|
||
Epub 2016 Feb 3
|
||
doi: 10.1038/nrgastro.2015.219.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26837712" target="_blank">26837712</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Immune%20dysregulation%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1418)</a></div></div>
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|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="nl"><a target="_blank" href="/pubmed/37595484">Dengue overview: An updated systemic review.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Khan MB,
|
||
Yang ZS,
|
||
Lin CY,
|
||
Hsu MC,
|
||
Urbina AN,
|
||
Assavalapsakul W,
|
||
Wang WH,
|
||
Chen YH,
|
||
Wang SF</span><br />
|
||
<span class="medgenPMjournal">J Infect Public Health</span>
|
||
2023 Oct;16(10):1625-1642.
|
||
Epub 2023 Aug 3
|
||
doi: 10.1016/j.jiph.2023.08.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37595484" target="_blank">37595484</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36191689">Allergen immunotherapy for atopic dermatitis: Systematic review and meta-analysis of benefits and harms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yepes-Nuñez JJ,
|
||
Guyatt GH,
|
||
Gómez-Escobar LG,
|
||
Pérez-Herrera LC,
|
||
Chu AWL,
|
||
Ceccaci R,
|
||
Acosta-Madiedo AS,
|
||
Wen A,
|
||
Moreno-López S,
|
||
MacDonald M,
|
||
Barrios M,
|
||
Chu X,
|
||
Islam N,
|
||
Gao Y,
|
||
Wong MM,
|
||
Couban R,
|
||
Garcia E,
|
||
Chapman E,
|
||
Oykhman P,
|
||
Chen L,
|
||
Winders T,
|
||
Asiniwasis RN,
|
||
Boguniewicz M,
|
||
De Benedetto A,
|
||
Ellison K,
|
||
Frazier WT,
|
||
Greenhawt M,
|
||
Huynh J,
|
||
Kim E,
|
||
LeBovidge J,
|
||
Lind ML,
|
||
Lio P,
|
||
Martin SA,
|
||
O'Brien M,
|
||
Ong PY,
|
||
Silverberg JI,
|
||
Spergel J,
|
||
Wang J,
|
||
Wheeler KE,
|
||
Schneider L,
|
||
Chu DK</span><br />
|
||
<span class="medgenPMjournal">J Allergy Clin Immunol</span>
|
||
2023 Jan;151(1):147-158.
|
||
Epub 2022 Sep 30
|
||
doi: 10.1016/j.jaci.2022.09.020.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36191689" target="_blank">36191689</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36231195">Diet and Systemic Lupus Erythematosus (SLE): From Supplementation to Intervention.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jiao H,
|
||
Acar G,
|
||
Robinson GA,
|
||
Ciurtin C,
|
||
Jury EC,
|
||
Kalea AZ</span><br />
|
||
<span class="medgenPMjournal">Int J Environ Res Public Health</span>
|
||
2022 Sep 20;19(19)
|
||
doi: 10.3390/ijerph191911895.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36231195" target="_blank">36231195</a><a href="/pmc/articles/PMC9565311" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32265181">Dengue hemorrhagic fever - A systemic literature review of current perspectives on pathogenesis, prevention and control.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang WH,
|
||
Urbina AN,
|
||
Chang MR,
|
||
Assavalapsakul W,
|
||
Lu PL,
|
||
Chen YH,
|
||
Wang SF</span><br />
|
||
<span class="medgenPMjournal">J Microbiol Immunol Infect</span>
|
||
2020 Dec;53(6):963-978.
|
||
Epub 2020 Mar 26
|
||
doi: 10.1016/j.jmii.2020.03.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32265181" target="_blank">32265181</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31605681">Pathophysiology, Clinical Manifestations, and Treatment of Lichen Sclerosus: A Systematic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fergus KB,
|
||
Lee AW,
|
||
Baradaran N,
|
||
Cohen AJ,
|
||
Stohr BA,
|
||
Erickson BA,
|
||
Mmonu NA,
|
||
Breyer BN</span><br />
|
||
<span class="medgenPMjournal">Urology</span>
|
||
2020 Jan;135:11-19.
|
||
Epub 2019 Oct 9
|
||
doi: 10.1016/j.urology.2019.09.034.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31605681" target="_blank">31605681</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Immune%20dysregulation%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (83)</a></div></div>
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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</div>
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||
<div class="row">
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||
<div class="col-lg-12 centered-lg">
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||
<nav class="bottom-links">
|
||
<ul class="mt-3">
|
||
<li>
|
||
<a class="text-white" href="//www.nlm.nih.gov/">NLM</a>
|
||
</li>
|
||
<li>
|
||
<a class="text-white" href="https://www.nih.gov/">NIH</a>
|
||
</li>
|
||
<li>
|
||
<a class="text-white" href="https://www.hhs.gov/">HHS</a>
|
||
</li>
|
||
<li>
|
||
<a class="text-white" href="https://www.usa.gov/">USA.gov</a>
|
||
</li>
|
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</ul>
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||
</nav>
|
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</div>
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</div>
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</section>
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<script type="text/javascript" src="/portal/portal3rc.fcgi/rlib/js/InstrumentOmnitureBaseJS/InstrumentNCBIConfigJS/InstrumentNCBIBaseJS/InstrumentPageStarterJS.js?v=1"> </script>
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<script type="text/javascript" src="/portal/portal3rc.fcgi/static/js/hfjs2.js"> </script>
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