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<!--
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UID=334198
|
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ConceptID=C1842581
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Abnormal corpus callosum morphology</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>334198</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1842581</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Anatomical Abnormality; Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Abnormality of the corpus callosum; Corpus callosum abnormalities</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0001273">HP:0001273</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">Abnormality of the corpus callosum. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1842581[DISCUI]&test_type=Clinical" ref="ncbi_uid=334198">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=334198" ref="ncbi_uid=334198">V</a></span></span><span class="TLline">Abnormal corpus callosum morphology</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/892343" ref="tree=MeSH" title="MedGen record for Morphological central nervous system abnormality">Morphological central nervous system abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/866738" ref="tree=MeSH" title="MedGen record for Abnormal brain morphology">Abnormal brain morphology</a></span><ul><li><span class="TLline"><a href="/medgen/866620" ref="tree=MeSH" title="MedGen record for Abnormal forebrain morphology">Abnormal forebrain morphology</a></span><ul><li><span class="TLline"><a href="/medgen/867394" ref="tree=MeSH" title="MedGen record for Abnormal cerebral morphology">Abnormal cerebral morphology</a></span><ul><li><span class="TLline"><a href="/medgen/866852" ref="tree=MeSH" title="MedGen record for Abnormal cerebral subcortex morphology">Abnormal cerebral subcortex morphology</a></span><ul><li><span class="TLline"><a href="/medgen/181756" ref="tree=MeSH" title="MedGen record for Abnormal cerebral white matter morphology">Abnormal cerebral white matter morphology</a></span><ul><li><span class="matched_ds">Abnormal corpus callosum morphology</span><ul><li><span class="TLline"><a href="/medgen/867520" ref="tree=MeSH" title="MedGen record for Abnormal length of corpus callosum">Abnormal length of corpus callosum</a></span><ul><li><span class="TLline"><a href="/medgen/867519" ref="tree=MeSH" title="MedGen record for Short corpus callosum">Short corpus callosum</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/98128" ref="tree=MeSH" title="MedGen record for Dysplastic corpus callosum">Dysplastic corpus callosum</a></span></li><li><span class="TLline"><a href="/medgen/1814227" ref="tree=MeSH" title="MedGen record for Probst bundles">Probst bundles</a></span></li><li><span class="TLline"><a href="/medgen/1671063" ref="tree=MeSH" title="MedGen record for Snowball lesion of corpus callosum">Snowball lesion of corpus callosum</a></span></li><li><span class="TLline"><a href="/medgen/371993" ref="tree=MeSH" title="MedGen record for Thick corpus callosum">Thick corpus callosum</a></span></li><li><span class="TLline"><a href="/medgen/1785336" ref="tree=MeSH" title="MedGen record for Thin corpus callosum">Thin corpus callosum</a></span><ul><li><span class="TLline"><a href="/medgen/354608" ref="tree=MeSH" title="MedGen record for Aplasia/Hypoplasia of the corpus callosum">Aplasia/Hypoplasia of the corpus callosum</a></span><ul><li><span class="TLline"><a href="/medgen/104498" ref="tree=MeSH" title="MedGen record for Corpus callosum, agenesis of">Corpus callosum, agenesis of</a></span></li><li><span class="TLline"><a href="/medgen/138005" ref="tree=MeSH" title="MedGen record for Hypoplasia of the corpus callosum">Hypoplasia of the corpus callosum</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/96560" ref="tree=MeSH" title="MedGen record for Corpus callosum atrophy">Corpus callosum atrophy</a></span></li><li><span class="TLline"><a href="/medgen/1786962" ref="tree=MeSH" title="MedGen record for Posterior atrophy of corpus callosum">Posterior atrophy of corpus callosum</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
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<div class="portlet mgSection" id="ID_112">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_332113"><div><strong>CEDNIK syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>332113</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1836033</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Cerebral dysgenesis, neuropathy, ichthyosis, and keratoderma syndrome (CEDNIK) refers to a unique constellation of clinical manifestations including global developmental delay with hypotonia, roving eye movements or nystagmus, poor motor skills, and impaired intellectual development with speech delay. More variable features include microcephaly, feeding difficulties, seizures, ocular anomalies, hearing loss, and nonspecific dysmorphic facial features. Palmoplantar keratoderma and ichthyosis or neuropathy develop in some patients. Brain magnetic resonance imaging (MRI) shows varying degrees of cerebral dysgenesis, including absence of the corpus callosum and cortical dysplasia, as well as hypomyelination, white matter loss, and white matter signal anomalies suggestive of a leukodystrophy. Some patients may show developmental regression; many die in childhood (Fuchs-Telem et al., 2011; Mah-Som et al., 2021). With more patients being reported, several authors (Diggle et al., 2017; Llaci et al., 2019; Mah-Som et al., 2021) have observed that the dermatologic features and peripheral neuropathy show reduced penetrance and are more variable manifestations of this disorder, as they are not observed in all patients with biallelic SNAP29 mutations.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/332113">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_334114"><div><strong>Joubert syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>334114</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1842577</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Classic Joubert syndrome (JS) is characterized by three primary findings: A distinctive cerebellar and brain stem malformation called the molar tooth sign (MTS). Hypotonia. Developmental delays. Often these findings are accompanied by episodic tachypnea or apnea and/or atypical eye movements. In general, the breathing abnormalities improve with age, truncal ataxia develops over time, and acquisition of gross motor milestones is delayed. Cognitive abilities are variable, ranging from severe intellectual disability to normal. Additional findings can include retinal dystrophy, renal disease, ocular colobomas, occipital encephalocele, hepatic fibrosis, polydactyly, oral hamartomas, and endocrine abnormalities. Both intra- and interfamilial variation are seen.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/334114">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_341067"><div><strong>Mowat-Wilson syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>341067</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C1856113</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Mowat-Wilson syndrome (MWS) is characterized by distinctive facial features (widely spaced eyes, broad eyebrows with a medial flare, low-hanging columella, prominent or pointed chin, open-mouth expression, and uplifted earlobes with a central depression), congenital heart defects with predilection for abnormalities of the pulmonary arteries and/or valves, Hirschsprung disease or chronic constipation, genitourinary anomalies (particularly hypospadias in males), and hypogenesis or agenesis of the corpus callosum. Most affected individuals have moderate-to-severe intellectual disability. Speech is typically limited to a few words or is absent, with relative preservation of receptive language skills. Growth restriction with microcephaly and seizure disorder are also common. Most affected people have a happy demeanor and a wide-based gait that can sometimes be confused with Angelman syndrome.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/341067">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_369401"><div><strong>Joubert syndrome 7</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>369401</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1969053</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Classic Joubert syndrome (JS) is characterized by three primary findings: A distinctive cerebellar and brain stem malformation called the molar tooth sign (MTS). Hypotonia. Developmental delays. Often these findings are accompanied by episodic tachypnea or apnea and/or atypical eye movements. In general, the breathing abnormalities improve with age, truncal ataxia develops over time, and acquisition of gross motor milestones is delayed. Cognitive abilities are variable, ranging from severe intellectual disability to normal. Additional findings can include retinal dystrophy, renal disease, ocular colobomas, occipital encephalocele, hepatic fibrosis, polydactyly, oral hamartomas, and endocrine abnormalities. Both intra- and interfamilial variation are seen.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/369401">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_766161"><div><strong>Intellectual disability, autosomal dominant 14</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766161</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3553247</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Coffin-Siris syndrome is a congenital malformation syndrome characterized by developmental delay, intellectual disability, coarse facial features, feeding difficulties, and hypoplastic or absent fifth fingernails and fifth distal phalanges. Other more variable features may also occur. Patients with ARID1A mutations have a wide spectrum of manifestations, from severe intellectual disability and serious internal complications that could result in early death to mild intellectual disability (summary by Kosho et al., 2014). For a general phenotypic description and a discussion of genetic heterogeneity of Coffin-Siris syndrome, see CSS1 (135900). The chromosome 1p36.11 duplication syndrome, in which the ARID1A gene is duplicated, is characterized by impaired intellectual development, microcephaly, dysmorphic facial features, and hand and foot anomalies.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/766161">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_766162"><div><strong>Intellectual disability, autosomal dominant 15</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766162</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3553248</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Coffin-Siris syndrome is a congenital malformation syndrome characterized by developmental delay, intellectual disability, coarse facial features, feeding difficulties, and hypoplastic or absent fifth fingernails and fifth distal phalanges. Other more variable features may also occur. Patients with SMARCB1 mutations may have more severe neurodevelopmental deficits including severe intellectual disability, brain structural abnormalities, and no expressive words, as well as scoliosis (summary by Kosho et al., 2014). For a general phenotypic description and a discussion of genetic heterogeneity of Coffin-Siris syndrome, see CSS1 (135900).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/766162">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1677602"><div><strong>O'Donnell-Luria-Rodan syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1677602</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5193138</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">KMT2E-related neurodevelopmental disorder (KMT2E-NDD) is a condition characterized by global developmental delay, variable intellectual disability (typically in the mild-to-moderate range), and hypotonia. The majority of affected individuals are verbal but experience speech delays with or without articulation problems. All reported individuals who are older than infants have been able to obtain independent ambulation. About one third of affected individuals develop seizures, with no consistent seizure semiology or epilepsy syndrome. However, females may be more likely to develop seizures compared to males. Similarly, about one third of affected individuals have an autism spectrum disorder diagnosis, of which most to date are male. Growth parameters are typically in the normal range for length/height and weight, although about half of affected individuals have macrocephaly or relative macrocephaly. Constipation is the most frequent gastrointestinal issue, although gastroesophageal reflux, vomiting, and/or reduced bowel motility have been reported in almost half of affected individuals. About half of affected individuals experience some type of sleep disturbance, including frequent awakening and difficulties falling asleep.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1677602">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1684757"><div><strong>Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1684757</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5231470</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Neurodevelopmental disorder with nonspecific brain abnormalities is a highly variable syndrome characterized by impaired intellectual development and behavioral abnormalities associated with structural changes on brain imaging. Some patients have seizures, hypotonia, and scoliosis/kyphosis. Cognitive function ranges from severely impaired to the ability to attend schools with special assistance (summary by Fischer-Zirnsak et al., 2019).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1684757">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1748867"><div><strong>Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1748867</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5399977</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Mitochondrial complex IV deficiency nuclear type 2 (MC4DN2) is an autosomal recessive multisystem metabolic disorder characterized by the onset of symptoms at birth or in the first weeks or months of life. Affected individuals have severe hypotonia, often associated with feeding difficulties and respiratory insufficiency necessitating tube feeding and mechanical ventilation. The vast majority of patients develop hypertrophic cardiomyopathy in the first days or weeks of life, which usually leads to death in infancy or early childhood. Patients also show neurologic abnormalities, including developmental delay, nystagmus, fasciculations, dystonia, EEG changes, and brain imaging abnormalities compatible with a diagnosis of Leigh syndrome (see 256000). There may also be evidence of systemic involvement with hepatomegaly and myopathy, although neurogenic muscle atrophy is more common and may resemble spinal muscular atrophy type I (SMA1; 253300). Serum lactate is increased, and laboratory studies show decreased mitochondrial complex IV protein and activity levels in various tissues, including heart and skeletal muscle. Most patients die in infancy of cardiorespiratory failure (summary by Papadopoulou et al., 1999). For a discussion of genetic heterogeneity of mitochondrial complex IV (cytochrome c oxidase) deficiency, see 220110.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1748867">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1748867" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_332113" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">CEDNIK syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_766161" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Intellectual disability, autosomal dominant 14</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_766162" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Intellectual disability, autosomal dominant 15</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_334114" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Joubert syndrome 2</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (9)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_369401" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Joubert syndrome 7</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_341067" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Mowat-Wilson syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1684757" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1677602" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">O'Donnell-Luria-Rodan syndrome</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32895917">Comprehensive genotype-phenotype correlation in AP-4 deficiency syndrome; Adding data from a large cohort of Iranian patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Beheshtian M,
|
||
Akhtarkhavari T,
|
||
Mehvari S,
|
||
Mohseni M,
|
||
Fattahi Z,
|
||
Abedini SS,
|
||
Arzhangi S,
|
||
Fadaee M,
|
||
Jamali P,
|
||
Najafipour R,
|
||
Kalscheuer VM,
|
||
Hu H,
|
||
Ropers HH,
|
||
Najmabadi H,
|
||
Kahrizi K</span><br />
|
||
<span class="medgenPMjournal">Clin Genet</span>
|
||
2021 Jan;99(1):187-192.
|
||
Epub 2020 Sep 14
|
||
doi: 10.1111/cge.13845.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32895917" target="_blank">32895917</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22abnormal%20corpus%20callosum%20morphology%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (1)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37816486">Outcome of partial agenesis of corpus callosum.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">De Keersmaecker B,
|
||
Jansen K,
|
||
Aertsen M,
|
||
Naulaers G,
|
||
De Catte L</span><br />
|
||
<span class="medgenPMjournal">Am J Obstet Gynecol</span>
|
||
2024 Apr;230(4):456.e1-456.e9.
|
||
Epub 2023 Oct 8
|
||
doi: 10.1016/j.ajog.2023.10.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37816486" target="_blank">37816486</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31408229">Diagnosis of fetal non-chromosomal abnormalities on routine ultrasound examination at 11-13 weeks' gestation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Syngelaki A,
|
||
Hammami A,
|
||
Bower S,
|
||
Zidere V,
|
||
Akolekar R,
|
||
Nicolaides KH</span><br />
|
||
<span class="medgenPMjournal">Ultrasound Obstet Gynecol</span>
|
||
2019 Oct;54(4):468-476.
|
||
doi: 10.1002/uog.20844.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31408229" target="_blank">31408229</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30448279">Fetal midline anomalies: Diagnosis and counselling Part 1: Corpus callosum anomalies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Leombroni M,
|
||
Khalil A,
|
||
Liberati M,
|
||
D'Antonio F</span><br />
|
||
<span class="medgenPMjournal">Eur J Paediatr Neurol</span>
|
||
2018 Nov;22(6):951-962.
|
||
Epub 2018 Oct 21
|
||
doi: 10.1016/j.ejpn.2018.08.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30448279" target="_blank">30448279</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22273241">Imaging spectrum of pediatric corpus callosal pathology: a pictorial review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hyun Yoo J,
|
||
Hunter J</span><br />
|
||
<span class="medgenPMjournal">J Neuroimaging</span>
|
||
2013 Apr;23(2):281-95.
|
||
Epub 2012 Jan 24
|
||
doi: 10.1111/j.1552-6569.2011.00681.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22273241" target="_blank">22273241</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7617572">Assessment and management of fetal agenesis of the corpus callosum.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gupta JK,
|
||
Lilford RJ</span><br />
|
||
<span class="medgenPMjournal">Prenat Diagn</span>
|
||
1995 Apr;15(4):301-12.
|
||
doi: 10.1002/pd.1970150402.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7617572" target="_blank">7617572</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormal%20corpus%20callosum%20morphology%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1428)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37816486">Outcome of partial agenesis of corpus callosum.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">De Keersmaecker B,
|
||
Jansen K,
|
||
Aertsen M,
|
||
Naulaers G,
|
||
De Catte L</span><br />
|
||
<span class="medgenPMjournal">Am J Obstet Gynecol</span>
|
||
2024 Apr;230(4):456.e1-456.e9.
|
||
Epub 2023 Oct 8
|
||
doi: 10.1016/j.ajog.2023.10.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37816486" target="_blank">37816486</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31408229">Diagnosis of fetal non-chromosomal abnormalities on routine ultrasound examination at 11-13 weeks' gestation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Syngelaki A,
|
||
Hammami A,
|
||
Bower S,
|
||
Zidere V,
|
||
Akolekar R,
|
||
Nicolaides KH</span><br />
|
||
<span class="medgenPMjournal">Ultrasound Obstet Gynecol</span>
|
||
2019 Oct;54(4):468-476.
|
||
doi: 10.1002/uog.20844.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31408229" target="_blank">31408229</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27010176">Corpus callosum and epilepsies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Unterberger I,
|
||
Bauer R,
|
||
Walser G,
|
||
Bauer G</span><br />
|
||
<span class="medgenPMjournal">Seizure</span>
|
||
2016 Apr;37:55-60.
|
||
Epub 2016 Mar 3
|
||
doi: 10.1016/j.seizure.2016.02.012.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27010176" target="_blank">27010176</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22815034">Aicardi syndrome.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Singh P,
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Goraya JS,
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Ahluwalia A</span><br />
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2012 Jul;53(7):e153-5.
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<span class="bold">PMID: </span><a href="/pubmed/22815034" target="_blank">22815034</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/22529205">Corpus callosum lipoma.</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormal%20corpus%20callosum%20morphology%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1834)</a></div><h3 class="subhead">Therapy</h3>
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<div class="nl"><a target="_blank" href="/pubmed/35203331">Central Nervous System Complications in Cystinosis: The Role of Neuroimaging.</a></div>
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Reynolds CF 3rd,
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<div class="nl"><a target="_blank" href="/pubmed/24640213">Shapiro syndrome.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Mathur S,
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Mathur A,
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<div class="nl"><a target="_blank" href="/pubmed/22529205">Corpus callosum lipoma.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Rajan DS,
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Popescu A</span><br />
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<span class="medgenPMjournal">Neurology</span>
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2012 Apr 24;78(17):1366.
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doi: 10.1212/WNL.0b013e318251838b.
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<span class="bold">PMID: </span><a href="/pubmed/22529205" target="_blank">22529205</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/22118709">Hereditary spastic paraplegia and psychosis: connected by the corpus callosum?</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormal%20corpus%20callosum%20morphology%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (259)</a></div><h3 class="subhead">Prognosis</h3>
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<div class="nl"><a target="_blank" href="/pubmed/39831641">Fetal Corpus Callosum Anomalies: A Review of Underlying Genetic Disorders and Prenatal Testing Options.</a></div>
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<span class="bold">PMID: </span><a href="/pubmed/39831641" target="_blank">39831641</a><a href="/pmc/articles/PMC11892088" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/33168214">Absent Cavum Septi Pellucidi.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Society for Maternal-Fetal Medicine (SMFM),
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Ward A,
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Monteagudo A</span><br />
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2020 Dec;223(6):B23-B26.
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<span class="bold">PMID: </span><a href="/pubmed/33168214" target="_blank">33168214</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/30744660">The mutational and phenotypic spectrum of TUBA1A-associated tubulinopathy.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Hebebrand M,
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Hüffmeier U,
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Trollmann R,
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Hehr U,
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Uebe S,
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Ekici AB,
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Kraus C,
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Krumbiegel M,
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Reis A,
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Thiel CT,
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Popp B</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/30744660" target="_blank">30744660</a><a href="/pmc/articles/PMC6371496" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/22768674">Warburg Micro syndrome.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Dursun F,
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<span class="bold">PMID: </span><a href="/pubmed/22768674" target="_blank">22768674</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/9588537">Microlissencephaly.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Sztriha L,
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Al-Gazali L,
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Várady E,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormal%20corpus%20callosum%20morphology%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (779)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/39480348">Corpus callosum structure and auditory interhemispheric transfer in spina bifida myelomeningocele.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Bradley KA,
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Juranek JJ,
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Hannay HJ,
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doi: 10.1037/neu0000915.
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<span class="bold">PMID: </span><a href="/pubmed/39480348" target="_blank">39480348</a><a href="/pmc/articles/PMC11891799" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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|
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<div class="nl"><a target="_blank" href="/pubmed/37078131">Children with corpus callosum anomalies: clinical characteristics and developmental outcomes.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Jańczewska I,
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Preis-Orlikowska J,
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Domżalska-Popadiuk I,
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<div class="nl"><a target="_blank" href="/pubmed/36480557">Development of the corpus callosum and cognition after neonatal encephalopathy.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Byrne H,
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Spencer APC,
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Geary G,
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Jary S,
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Thoresen M,
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Brooks JCW,
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<div class="nl"><a target="_blank" href="/pubmed/30744660">The mutational and phenotypic spectrum of TUBA1A-associated tubulinopathy.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Hebebrand M,
|
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Hüffmeier U,
|
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Trollmann R,
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Hehr U,
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Uebe S,
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Ekici AB,
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Kraus C,
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Krumbiegel M,
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Reis A,
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Thiel CT,
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Popp B</span><br />
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<span class="medgenPMjournal">Orphanet J Rare Dis</span>
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2019 Feb 11;14(1):38.
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doi: 10.1186/s13023-019-1020-x.
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<span class="bold">PMID: </span><a href="/pubmed/30744660" target="_blank">30744660</a><a href="/pmc/articles/PMC6371496" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8060424">Corpus callosum agenesis and epilepsy: PET findings.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Khanna S,
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Chugani HT,
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Messa C,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormal%20corpus%20callosum%20morphology%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1084)</a></div></div>
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||
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|
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<div class="portlet mgSection" id="ID_104">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">
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<div class="nl"><a target="_blank" href="/pubmed/36931328">Abnormal white matter changes in Alzheimer's disease based on diffusion tensor imaging: A systematic review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Chen Y,
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Wang Y,
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Song Z,
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Fan Y,
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Gao T,
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Tang X</span><br />
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<span class="medgenPMjournal">Ageing Res Rev</span>
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2023 Jun;87:101911.
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Epub 2023 Mar 15
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||
doi: 10.1016/j.arr.2023.101911.
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<span class="bold">PMID: </span><a href="/pubmed/36931328" target="_blank">36931328</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35149304">White matter microstructure in children and adolescents with ADHD.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Connaughton M,
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Whelan R,
|
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O'Hanlon E,
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McGrath J</span><br />
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<span class="medgenPMjournal">Neuroimage Clin</span>
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2022;33:102957.
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Epub 2022 Feb 7
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doi: 10.1016/j.nicl.2022.102957.
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<span class="bold">PMID: </span><a href="/pubmed/35149304" target="_blank">35149304</a><a href="/pmc/articles/PMC8842077" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33581793">Hereditary spastic paraplegia type 11: Clinicogenetic lessons from 339 patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Du J</span><br />
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<span class="medgenPMjournal">J Clin Neurosci</span>
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2021 Mar;85:67-71.
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Epub 2021 Jan 15
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doi: 10.1016/j.jocn.2020.11.036.
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<span class="bold">PMID: </span><a href="/pubmed/33581793" target="_blank">33581793</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31587959">Prenatal diagnosis of pericallosal lipoma: Systematic review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Joigneau Prieto L,
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Ruiz Y,
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||
Pérez R,
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||
De León Luis J</span><br />
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<span class="medgenPMjournal">Eur J Paediatr Neurol</span>
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2019 Nov;23(6):764-782.
|
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Epub 2019 Sep 25
|
||
doi: 10.1016/j.ejpn.2019.09.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31587959" target="_blank">31587959</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23406512">Systematic review of central nervous system anomalies in incontinentia pigmenti.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Minić S,
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Trpinac D,
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Obradović M</span><br />
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<span class="medgenPMjournal">Orphanet J Rare Dis</span>
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2013 Feb 13;8:25.
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<span class="bold">PMID: </span><a href="/pubmed/23406512" target="_blank">23406512</a><a href="/pmc/articles/PMC3576363" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormal%20corpus%20callosum%20morphology%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (41)</a></div></div>
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C1842581%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (5)</a></li>
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<li><a href="/gtr/tests?term=C1842581%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (5)</a></li>
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