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<!--
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UID=333452
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ConceptID=C1839969
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Reduced natural killer cell activity</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>333452</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1839969</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0012178">HP:0012178</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">Reduced ability of the natural killer cell to function in the adaptive immune response. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Reduced natural killer cell activity</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/867388" ref="tree=MeSH" title="MedGen record for Abnormality of the immune system">Abnormality of the immune system</a></span><ul><li><span class="TLline"><a href="/medgen/869194" ref="tree=MeSH" title="MedGen record for Abnormality of immune system physiology">Abnormality of immune system physiology</a></span><ul><li><span class="TLline"><a href="/medgen/1780121" ref="tree=MeSH" title="MedGen record for Abnormal leukocyte physiology">Abnormal leukocyte physiology</a></span><ul><li><span class="TLline"><a href="/medgen/1627345" ref="tree=MeSH" title="MedGen record for Abnormal lymphocyte physiology">Abnormal lymphocyte physiology</a></span><ul><li><span class="TLline"><a href="/medgen/868613" ref="tree=MeSH" title="MedGen record for Abnormal natural killer cell physiology">Abnormal natural killer cell physiology</a></span><ul><li><span class="matched_ds">Reduced natural killer cell activity</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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||
</div>
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<div class="portlet mgSection" id="ID_112">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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||
<div class="divPopper rprt" id="rdis_21921"><div><strong>Wiskott-Aldrich syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>21921</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0043194</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The WAS-related disorders, which include Wiskott-Aldrich syndrome, X-linked thrombocytopenia (XLT), and X-linked neutropenia (XLN), are a spectrum of disorders of hematopoietic cells, with predominant defects of platelets and lymphocytes. Wiskott-Aldrich syndrome usually presents in infancy. Affected males have thrombocytopenia with intermittent mucosal bleeding, bloody diarrhea, and intermittent or chronic petechiae and purpura; recurrent bacterial, viral, fungal, and/or opportunistic infections; and eczema. Approximately 25%-40% of those who survive the early complications develop one or more autoimmune conditions including hemolytic anemia, immune thrombocytopenic purpura, immune-mediated neutropenia, vasculitis, rheumatoid arthritis, and immune-mediated damage to the kidneys and liver. Individuals with a WAS-related disorder, particularly those who have been exposed to Epstein-Barr virus (EBV), are at increased risk of developing lymphomas, which often occur in unusual extranodal locations including the brain, lung, or gastrointestinal tract. Males with XLT have small platelet volume and thrombocytopenia. Severe disease-related events include severe bleeding episodes (14%), autoimmunity (12%), life-threatening infections (7%), and malignancy (5%). Males with XLN typically have congenital neutropenia associated with myelodysplasia, hyperactive neutrophils, increased myeloid cell apoptosis, and lymphoid cell abnormalities.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/21921">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_220906"><div><strong>X-linked severe combined immunodeficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>220906</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C1279481</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The phenotypic spectrum of X-linked severe combined immunodeficiency (X-SCID) ranges from typical X-SCID (early-onset disease in males that is fatal if not treated with hematopoietic stem cell transplantation [HSCT] or gene therapy) to atypical X-SCID (later-onset disease comprising phenotypes caused by variable immunodeficiency, immune dysregulation, and/or autoimmunity). Typical X-SCID. Prior to universal newborn screening (NBS) for SCID most males with typical X-SCID came to medical attention between ages three and six months because of recurrent infections, persistent infections, and infections with opportunistic organisms. With universal NBS for SCID, the common presentation for typical X-SCID is now an asymptomatic, healthy-appearing male infant. Atypical X-SCID, which usually is not detected by NBS, can manifest in the first years of life or later with one of the following: recurrent upper and lower respiratory tract infections with bronchiectasis; Omenn syndrome, a clinical phenotype caused by immune dysregulation; X-SCID combined immunodeficiency (often with recurrent infections, warts, and dermatitis); immune dysregulation and autoimmunity; or Epstein-Barr virus-related lymphoproliferative complications.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/220906">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_332383"><div><strong>Familial hemophagocytic lymphohistiocytosis 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>332383</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1837174</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Secretion of the contents of cytolytic granules at the immunologic synapse is a highly regulated process essential for lymphocyte cytotoxicity. This process requires the rapid transfer of perforin (170280)-containing lytic granules to the target cell interface, followed by their docking and fusion with the plasma membrane. Familial hemophagocytic lymphohistiocytosis is a genetically heterogeneous condition characterized by defective cytotoxicity. For a more detailed description of FHL, see 267700.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/332383">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_374912"><div><strong>Hermansky-Pudlak syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>374912</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1842362</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hermansky-Pudlak syndrome (HPS) is characterized by oculocutaneous albinism, a bleeding diathesis, and, in some individuals, pulmonary fibrosis, granulomatous colitis, and/or immunodeficiency. Ocular findings include nystagmus, reduced iris pigment, reduced retinal pigment, foveal hypoplasia with significant reduction in visual acuity (usually in the range of 20/50 to 20/400), and strabismus in many individuals. Hair color ranges from white to brown; skin color ranges from white to olive and is usually at least a shade lighter than that of other family members. The bleeding diathesis can result in variable degrees of bruising, epistaxis, gingival bleeding, postpartum hemorrhage, colonic bleeding, and prolonged bleeding with menses or after tooth extraction, circumcision, and/or other surgeries. Pulmonary fibrosis, colitis, and/or neutropenia have been reported in individuals with pathogenic variants in some HPS-related genes. Pulmonary fibrosis, a restrictive lung disease, typically causes symptoms in the early 30s and can progress to death within a decade. Granulomatous colitis is severe in about 15% of affected individuals. Neutropenia and/or immune defects occur primarily in individuals with pathogenic variants in AP3B1 and AP3D1.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/374912">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_375787"><div><strong>Ectodermal dysplasia and immunodeficiency 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>375787</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1846008</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Ectodermal dysplasia with immunodeficiency-1 (EDAID1) is an X-linked recessive disorder that characteristically affects only males. Affected individuals have onset of recurrent severe infections due to immunodeficiency in early infancy or in the first years of life. There is increased susceptibility to bacterial, pneumococcal, mycobacterial, and fungal infections. Laboratory studies usually show dysgammaglobulinemia with low IgG subsets and normal or increased IgA and IgM, consistent with impaired 'class-switching' of B cells, although immunologic abnormalities may be subtle compared to the clinical picture, and B- and T-cell numbers are usually normal. There is a poor antibody response to polysaccharide vaccinations, particularly pneumococcus; response to other vaccinations is variable. Patients also have features of ectodermal dysplasia, including conical incisors, hypo/anhidrosis, and thin skin or hair. Severely affected individuals may also show lymphedema, osteopetrosis, and, rarely, hematologic abnormalities. The phenotype is highly variable, likely due to different hypomorphic mutations, and may be fatal in childhood. Intravenous immunoglobulins and prophylactic antibiotics are used as treatment; some patients may benefit from bone marrow transplantation. Although only males tend to be affected with immunodeficiency, many patients inherit a mutation from a mother who has mild features of IP or conical teeth (summary by Doffinger et al., 2001, Orange et al., 2004, Roberts et al., 2010, Heller et al., 2020). Genetic Heterogeneity of Ectodermal Dysplasia and Immune Deficiency Also see EDAID2 (612132), caused by mutation in the NFKBIA gene (164008).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/375787">Condition Record</a></div></div>
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||
<div class="divPopper rprt" id="rdis_400366"><div><strong>Familial hemophagocytic lymphohistiocytosis 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>400366</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1863727</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">Familial hemophagocytic lymphohistiocytosis-2 (FHL2) is an autosomal recessive disorder of immune dysregulation with onset in infancy or early childhood. It is characterized clinically by fever, edema, hepatosplenomegaly, and liver dysfunction. Neurologic impairment, seizures, and ataxia are frequent. Laboratory studies show pancytopenia, coagulation abnormalities, hypofibrinogenemia, and hypertriglyceridemia. There is increased production of cytokines, such as gamma-interferon (IFNG; 147570) and TNF-alpha (191160), by hyperactivation and proliferation of T cells and macrophages. Activity of cytotoxic T cells and NK cells is reduced, consistent with a defect in cellular cytotoxicity. Bone marrow, lymph nodes, spleen, and liver show features of hemophagocytosis. Chemotherapy and/or immunosuppressant therapy may result in symptomatic remission, but the disorder is fatal without bone marrow transplantation (summary by Dufourcq-Lagelouse et al., 1999, Stepp et al., 1999, and Molleran Lee et al., 2004). For a general phenotypic description and a discussion of genetic heterogeneity of FHL, see 267700.</div>
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||
<div class="spaceAbove nowrap">See: <a href="/medgen/400366">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_482631"><div><strong>Wiskott-Aldrich syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>482631</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3281001</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Wiskott-Aldrich syndrome-2 (WAS2) is an autosomal recessive immunologic disorder characterized by onset of recurrent infections in infancy. Other features include thrombocytopenia with normal platelet volume and eczema. Laboratory studies show decreased CD8+ T cells, variably increased Ig, particularly IgE, low B cells, aberrant function of T and NK cells, and impaired T-cell migration. The cellular abnormalities are thought to result from defective F-actin polymerization. Death in early childhood may occur; hematopoietic stem cell transplantation is curative (summary by Lanzi et al., 2012). For a discussion of genetic heterogeneity of Wiskott-Aldrich syndrome, see WAS (301000).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/482631">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_816258"><div><strong>Autoimmune lymphoproliferative syndrome, type III caused by mutation in PRKCD</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>816258</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3809928</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autoimmune lymphoproliferative syndrome type III is an autosomal recessive disorder of immune dysregulation. The phenotype is variable, but most patients have significant lymphadenopathy associated with variable autoimmune manifestations. Some patients may have recurrent infections. Lymphocyte accumulation results from a combination of impaired apoptosis and excessive proliferation (summary by Oliveira, 2013). For a general description and a discussion of genetic heterogeneity of ALPS, see 601859.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/816258">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_816672"><div><strong>Autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>816672</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3810342</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Immunodeficiency-20 is a rare autosomal recessive primary immunodeficiency characterized by functional deficiency of NK cells. Patient NK cells are defective in spontaneous cell cytotoxicity, but retain antibody-dependent cellular cytotoxicity. Patients typically present early in childhood with severe herpes viral infections, particularly Epstein Barr virus (EBV), and human papillomavirus (HPV) (summary by Grier et al., 2012).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/816672">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_863504"><div><strong>Periodic fever-infantile enterocolitis-autoinflammatory syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>863504</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4015067</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autoinflammation with infantile enterocolitis is an autosomal dominant disorder characterized by onset of recurrent flares of autoinflammation in early infancy. Affected individuals tend to have poor overall growth and gastrointestinal symptoms in infancy associated with laboratory evidence of activated inflammation. This initial presentation is followed by recurrent febrile episodes with splenomegaly and sometimes hematologic disturbances, arthralgias, or myalgias. The disorder results from overactivation of an arm of the immune response system (Romberg et al., 2014; Canna et al., 2014).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/863504">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1770239"><div><strong>X-linked lymphoproliferative disease due to SH2D1A deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1770239</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5399825</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">X-linked lymphoproliferative disease (XLP) in general is characterized by an inappropriate immune response to Epstein-Barr virus (EBV) infection leading to hemophagocytic lymphohistiocytosis (HLH) or severe mononucleosis, dysgammaglobulinemia, and lymphoproliferative disease (malignant lymphoma). The condition primarily affects males. XLP has two recognizable subtypes, XLP1 (due to pathogenic variants in SH2D1A) and XLP2 (due to pathogenic variants in XIAP). HLH / fulminant infectious mononucleosis is the most common presentation regardless of subtype. HLH is characterized as an acute illness with prolonged and high fever, bi- or trilineage cytopenias, and hepatosplenomegaly, which is often severe or fatal. Death is generally secondary to liver failure or multisystem organ dysfunction. In those with XLP1, dys- or hypogammaglobulinemia can lead to varying degrees of humoral immune dysfunction associated with bronchiectasis and recurrent respiratory infections that, if untreated, may result in death. Lymphoproliferative disease (malignant lymphoma) and other lymphoproliferative diseases are specific to XLP1 and often develop in childhood, usually following EBV exposure. Rarer findings in those with XLP1 can include aplastic anemia, vasculitis, and lymphoid granulomatosis. Males with XLP2 are more likely to have HLH without EBV infection, recurrent episodes of HLH (which is not typically seen in those with XLP1), splenomegaly, and gastrointestinal disease, including enterocolitis and perirectal abscesses or fistulae. Rarely, individuals with XLP2 and inflammatory bowel disease have been reported to develop inflammatory liver disease, which can progress to fatal liver failure. Transient hypogammaglobulinemia has been rarely observed in those with XLP2. To date, neither lymphoproliferative disease nor common variable immunodeficiency has been reported in males with XLP2. Heterozygous females rarely have symptoms. There are, however, increasing numbers of reports of affected females with unfavorable (skewed) X-chromosome inactivation favoring the X chromosome with the pathogenic variant who develop HLH, inflammatory bowel disease, and erythema nodosum.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1770239">Condition Record</a></div></div>
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||
<div class="divPopper rprt" id="rdis_1787468"><div><strong>Immunodeficiency 14b, autosomal recessive</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1787468</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5543301</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autosomal recessive primary immunodeficiency-14B (IMD14B) is characterized by onset of recurrent infections in early childhood. Most patients have respiratory infections, but some may develop inflammatory bowel disease or osteomyelitis. Laboratory studies tend to show hypogammaglobulinemia and decreased levels of B cells. Although NK cell and T cell numbers are normal, there may be evidence of impaired immune-mediated cytotoxicity and defective T-cell function (summary by et al., 2018 and et al., 2019).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1787468">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1788669"><div><strong>Immunodeficiency 81</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1788669</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5543540</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">Immunodeficiency-81 (IMD81) is an autosomal recessive complex immunologic disorder with onset of symptoms in infancy. The phenotype is highly variable and may include both immunodeficiency with recurrent infections, including bacterial and fungal infections, as well as autoimmune features, including autoimmune hemolytic anemia, pancytopenia, thrombocytopenia, and inflammatory bowel disease. Immunologic workup shows immune dysregulation with abnormalities affecting multiple immune cell lineages, including T cells, B cells, NK cells, and neutrophils, which may be decreased or increased and demonstrate functional deficits. There is a wide range of hematologic abnormalities. Affected individuals may be susceptible to severe EBV infection. The disorder is caused by a defect in intracellular immune signaling pathways (summary by Lev et al., 2021; Edwards et al., 2023).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1788669">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_816258" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autoimmune lymphoproliferative syndrome, type III caused by mutation in PRKCD</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_816672" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_375787" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ectodermal dysplasia and immunodeficiency 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_400366" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial hemophagocytic lymphohistiocytosis 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_332383" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial hemophagocytic lymphohistiocytosis 3</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (13)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_374912" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hermansky-Pudlak syndrome 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1787468" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Immunodeficiency 14b, autosomal recessive</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1788669" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Immunodeficiency 81</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_863504" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Periodic fever-infantile enterocolitis-autoinflammatory syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_21921" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Wiskott-Aldrich syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_482631" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Wiskott-Aldrich syndrome 2</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1770239" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">X-linked lymphoproliferative disease due to SH2D1A deficiency</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_220906" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">X-linked severe combined immunodeficiency</a></div></span></div></div>
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</div>
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<div class="portlet mgSection" id="ID_105">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
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<div class="nl"><a target="_blank" href="/pubmed/35418180">Primary CD33-targeting CAR-NK cells for the treatment of acute myeloid leukemia.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Albinger N,
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Pfeifer R,
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Nitsche M,
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Mertlitz S,
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Campe J,
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Stein K,
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Kreyenberg H,
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Schubert R,
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Quadflieg M,
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Schneider D,
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Kühn MWM,
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Penack O,
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Zhang C,
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Möker N,
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Ullrich E</span><br />
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<span class="medgenPMjournal">Blood Cancer J</span>
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2022 Apr 13;12(4):61.
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doi: 10.1038/s41408-022-00660-2.
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<span class="bold">PMID: </span><a href="/pubmed/35418180" target="_blank">35418180</a><a href="/pmc/articles/PMC9007937" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/34072732">CAR-NK Cells in the Treatment of Solid Tumors.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Wrona E,
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Borowiec M,
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Potemski P</span><br />
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<span class="medgenPMjournal">Int J Mol Sci</span>
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2021 May 31;22(11)
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doi: 10.3390/ijms22115899.
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<span class="bold">PMID: </span><a href="/pubmed/34072732" target="_blank">34072732</a><a href="/pmc/articles/PMC8197981" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/29540357">Pulmonary arterial hypertension: pathogenesis and clinical management.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Thenappan T,
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Ormiston ML,
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Ryan JJ,
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Archer SL</span><br />
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<span class="medgenPMjournal">BMJ</span>
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2018 Mar 14;360:j5492.
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doi: 10.1136/bmj.j5492.
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||
<span class="bold">PMID: </span><a href="/pubmed/29540357" target="_blank">29540357</a><a href="/pmc/articles/PMC6889979" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(reduced%20natural%20killer%20cell%20activity)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (136)</a></div></div>
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<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
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|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34819201">A systematic review on shared biological mechanisms of depression and anxiety in comorbidity with psoriasis, atopic dermatitis, and hidradenitis suppurativa.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fabrazzo M,
|
||
Cipolla S,
|
||
Signoriello S,
|
||
Camerlengo A,
|
||
Calabrese G,
|
||
Giordano GM,
|
||
Argenziano G,
|
||
Galderisi S</span><br />
|
||
<span class="medgenPMjournal">Eur Psychiatry</span>
|
||
2021 Nov 25;64(1):e71.
|
||
doi: 10.1192/j.eurpsy.2021.2249.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34819201" target="_blank">34819201</a><a href="/pmc/articles/PMC8668448" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23980690">Minding the body: psychotherapy and cancer survival.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Spiegel D</span><br />
|
||
<span class="medgenPMjournal">Br J Health Psychol</span>
|
||
2014 Sep;19(3):465-85.
|
||
Epub 2013 Aug 26
|
||
doi: 10.1111/bjhp.12061.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23980690" target="_blank">23980690</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1514034">Reduced natural killer cell activity in multi-drug resistant pulmonary tuberculosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ratcliffe LT,
|
||
Mackenzie CR,
|
||
Lukey PT,
|
||
Ress SR</span><br />
|
||
<span class="medgenPMjournal">Scand J Immunol Suppl</span>
|
||
1992;11:167-70.
|
||
doi: 10.1111/j.1365-3083.1992.tb01643.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1514034" target="_blank">1514034</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1950471">Reduced natural killer cell activity in patients with dementia of the Alzheimer type.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Araga S,
|
||
Kagimoto H,
|
||
Funamoto K,
|
||
Takahashi K</span><br />
|
||
<span class="medgenPMjournal">Acta Neurol Scand</span>
|
||
1991 Sep;84(3):259-63.
|
||
doi: 10.1111/j.1600-0404.1991.tb04948.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1950471" target="_blank">1950471</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3196366">Reduced natural killer cell activity in patients with systemic sclerosis. Correlation with clinical disease type.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Miller EB,
|
||
Hiserodt JC,
|
||
Hunt LE,
|
||
Steen VD,
|
||
Medsger TA Jr</span><br />
|
||
<span class="medgenPMjournal">Arthritis Rheum</span>
|
||
1988 Dec;31(12):1515-23.
|
||
doi: 10.1002/art.1780311208.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3196366" target="_blank">3196366</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Reduced%20natural%20killer%20cell%20activity%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (15)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/29466462">Reduced NK cell IFN-γ secretion and psychological stress are independently associated with herpes zoster.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kim CK,
|
||
Choi YM,
|
||
Bae E,
|
||
Jue MS,
|
||
So HS,
|
||
Hwang ES</span><br />
|
||
<span class="medgenPMjournal">PLoS One</span>
|
||
2018;13(2):e0193299.
|
||
Epub 2018 Feb 21
|
||
doi: 10.1371/journal.pone.0193299.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29466462" target="_blank">29466462</a><a href="/pmc/articles/PMC5821387" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21146603">Epigenetic patterns associated with the immune dysregulation that accompanies psychosocial distress.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mathews HL,
|
||
Konley T,
|
||
Kosik KL,
|
||
Krukowski K,
|
||
Eddy J,
|
||
Albuquerque K,
|
||
Janusek LW</span><br />
|
||
<span class="medgenPMjournal">Brain Behav Immun</span>
|
||
2011 Jul;25(5):830-9.
|
||
Epub 2010 Dec 10
|
||
doi: 10.1016/j.bbi.2010.12.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21146603" target="_blank">21146603</a><a href="/pmc/articles/PMC3079772" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17092654">Psychologic stress, reduced NK cell activity, and cytokine dysregulation in women experiencing diagnostic breast biopsy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Witek-Janusek L,
|
||
Gabram S,
|
||
Mathews HL</span><br />
|
||
<span class="medgenPMjournal">Psychoneuroendocrinology</span>
|
||
2007 Jan;32(1):22-35.
|
||
Epub 2006 Nov 7
|
||
doi: 10.1016/j.psyneuen.2006.09.011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17092654" target="_blank">17092654</a><a href="/pmc/articles/PMC3937868" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11223375">Autoimmune ovarian failure: comparing the mouse model and the human disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nelson LM</span><br />
|
||
<span class="medgenPMjournal">J Soc Gynecol Investig</span>
|
||
2001 Jan-Feb;8(1 Suppl Proceedings):S55-7.
|
||
doi: 10.1016/s1071-5576(00)00110-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11223375" target="_blank">11223375</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8455400">Bronchogenic carcinoma: immunologic aspects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pisani RJ</span><br />
|
||
<span class="medgenPMjournal">Mayo Clin Proc</span>
|
||
1993 Apr;68(4):386-92.
|
||
doi: 10.1016/s0025-6196(12)60137-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8455400" target="_blank">8455400</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Reduced%20natural%20killer%20cell%20activity%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (9)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/29466462">Reduced NK cell IFN-γ secretion and psychological stress are independently associated with herpes zoster.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kim CK,
|
||
Choi YM,
|
||
Bae E,
|
||
Jue MS,
|
||
So HS,
|
||
Hwang ES</span><br />
|
||
<span class="medgenPMjournal">PLoS One</span>
|
||
2018;13(2):e0193299.
|
||
Epub 2018 Feb 21
|
||
doi: 10.1371/journal.pone.0193299.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29466462" target="_blank">29466462</a><a href="/pmc/articles/PMC5821387" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17092654">Psychologic stress, reduced NK cell activity, and cytokine dysregulation in women experiencing diagnostic breast biopsy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Witek-Janusek L,
|
||
Gabram S,
|
||
Mathews HL</span><br />
|
||
<span class="medgenPMjournal">Psychoneuroendocrinology</span>
|
||
2007 Jan;32(1):22-35.
|
||
Epub 2006 Nov 7
|
||
doi: 10.1016/j.psyneuen.2006.09.011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17092654" target="_blank">17092654</a><a href="/pmc/articles/PMC3937868" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9892855">Antidepressants augment natural killer cell activity: in vivo and in vitro.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Frank MG,
|
||
Hendricks SE,
|
||
Johnson DR,
|
||
Wieseler JL,
|
||
Burke WJ</span><br />
|
||
<span class="medgenPMjournal">Neuropsychobiology</span>
|
||
1999;39(1):18-24.
|
||
doi: 10.1159/000026555.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9892855" target="_blank">9892855</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9352028">Post-thymectomy murine experimental autoimmune oophoritis is associated with reduced natural killer cell activity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Maity R,
|
||
Nair SR,
|
||
Caspi RR,
|
||
Nelson LM</span><br />
|
||
<span class="medgenPMjournal">Am J Reprod Immunol</span>
|
||
1997 Nov;38(5):360-5.
|
||
doi: 10.1111/j.1600-0897.1997.tb00312.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9352028" target="_blank">9352028</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1646927">Chronic active hepatitis B. Interferon-activated natural killer-like cells against a hepatoma cell line transfected with the hepatitis B virus nucleic acid.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Actis GC,
|
||
Ponzetto A,
|
||
D'Urso N,
|
||
Saracco G,
|
||
Crepaldi T,
|
||
Bellone G,
|
||
Catucci LM,
|
||
Zarcone D,
|
||
Verme G</span><br />
|
||
<span class="medgenPMjournal">Liver</span>
|
||
1991 Apr;11(2):106-13.
|
||
doi: 10.1111/j.1600-0676.1991.tb00500.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1646927" target="_blank">1646927</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Reduced%20natural%20killer%20cell%20activity%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (10)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34819201">A systematic review on shared biological mechanisms of depression and anxiety in comorbidity with psoriasis, atopic dermatitis, and hidradenitis suppurativa.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fabrazzo M,
|
||
Cipolla S,
|
||
Signoriello S,
|
||
Camerlengo A,
|
||
Calabrese G,
|
||
Giordano GM,
|
||
Argenziano G,
|
||
Galderisi S</span><br />
|
||
<span class="medgenPMjournal">Eur Psychiatry</span>
|
||
2021 Nov 25;64(1):e71.
|
||
doi: 10.1192/j.eurpsy.2021.2249.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34819201" target="_blank">34819201</a><a href="/pmc/articles/PMC8668448" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30681594">Kawasaki disease shock syndrome complicated with macrophage activation syndrome in a 5-month old boy: A case report.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lin Y,
|
||
Shi L,
|
||
Deng YJ,
|
||
Liu Y,
|
||
Zhang HW</span><br />
|
||
<span class="medgenPMjournal">Medicine (Baltimore)</span>
|
||
2019 Jan;98(4):e14203.
|
||
doi: 10.1097/MD.0000000000014203.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30681594" target="_blank">30681594</a><a href="/pmc/articles/PMC6358384" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23980690">Minding the body: psychotherapy and cancer survival.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Spiegel D</span><br />
|
||
<span class="medgenPMjournal">Br J Health Psychol</span>
|
||
2014 Sep;19(3):465-85.
|
||
Epub 2013 Aug 26
|
||
doi: 10.1111/bjhp.12061.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23980690" target="_blank">23980690</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8455400">Bronchogenic carcinoma: immunologic aspects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pisani RJ</span><br />
|
||
<span class="medgenPMjournal">Mayo Clin Proc</span>
|
||
1993 Apr;68(4):386-92.
|
||
doi: 10.1016/s0025-6196(12)60137-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8455400" target="_blank">8455400</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7041921">Reduced natural killer cell activity in non-hodgkin's lymphoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Neri A,
|
||
Brugiatelli M,
|
||
Ozger Topuz U,
|
||
Astaldi G</span><br />
|
||
<span class="medgenPMjournal">Boll Ist Sieroter Milan</span>
|
||
1981 Nov;60(5):394-407.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7041921" target="_blank">7041921</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Reduced%20natural%20killer%20cell%20activity%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/29466462">Reduced NK cell IFN-γ secretion and psychological stress are independently associated with herpes zoster.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kim CK,
|
||
Choi YM,
|
||
Bae E,
|
||
Jue MS,
|
||
So HS,
|
||
Hwang ES</span><br />
|
||
<span class="medgenPMjournal">PLoS One</span>
|
||
2018;13(2):e0193299.
|
||
Epub 2018 Feb 21
|
||
doi: 10.1371/journal.pone.0193299.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29466462" target="_blank">29466462</a><a href="/pmc/articles/PMC5821387" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23980690">Minding the body: psychotherapy and cancer survival.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Spiegel D</span><br />
|
||
<span class="medgenPMjournal">Br J Health Psychol</span>
|
||
2014 Sep;19(3):465-85.
|
||
Epub 2013 Aug 26
|
||
doi: 10.1111/bjhp.12061.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23980690" target="_blank">23980690</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17092654">Psychologic stress, reduced NK cell activity, and cytokine dysregulation in women experiencing diagnostic breast biopsy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Witek-Janusek L,
|
||
Gabram S,
|
||
Mathews HL</span><br />
|
||
<span class="medgenPMjournal">Psychoneuroendocrinology</span>
|
||
2007 Jan;32(1):22-35.
|
||
Epub 2006 Nov 7
|
||
doi: 10.1016/j.psyneuen.2006.09.011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17092654" target="_blank">17092654</a><a href="/pmc/articles/PMC3937868" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2069835">Reduced natural killer cell activity and IL-2 production in malnourished cancer patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Villa ML,
|
||
Ferrario E,
|
||
Bergamasco E,
|
||
Bozzetti F,
|
||
Cozzaglio L,
|
||
Clerici E</span><br />
|
||
<span class="medgenPMjournal">Br J Cancer</span>
|
||
1991 Jun;63(6):1010-4.
|
||
doi: 10.1038/bjc.1991.219.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2069835" target="_blank">2069835</a><a href="/pmc/articles/PMC1972542" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3196366">Reduced natural killer cell activity in patients with systemic sclerosis. Correlation with clinical disease type.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Miller EB,
|
||
Hiserodt JC,
|
||
Hunt LE,
|
||
Steen VD,
|
||
Medsger TA Jr</span><br />
|
||
<span class="medgenPMjournal">Arthritis Rheum</span>
|
||
1988 Dec;31(12):1515-23.
|
||
doi: 10.1002/art.1780311208.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3196366" target="_blank">3196366</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Reduced%20natural%20killer%20cell%20activity%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (13)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/34819201">A systematic review on shared biological mechanisms of depression and anxiety in comorbidity with psoriasis, atopic dermatitis, and hidradenitis suppurativa.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fabrazzo M,
|
||
Cipolla S,
|
||
Signoriello S,
|
||
Camerlengo A,
|
||
Calabrese G,
|
||
Giordano GM,
|
||
Argenziano G,
|
||
Galderisi S</span><br />
|
||
<span class="medgenPMjournal">Eur Psychiatry</span>
|
||
2021 Nov 25;64(1):e71.
|
||
doi: 10.1192/j.eurpsy.2021.2249.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34819201" target="_blank">34819201</a><a href="/pmc/articles/PMC8668448" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23980690">Minding the body: psychotherapy and cancer survival.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Spiegel D</span><br />
|
||
<span class="medgenPMjournal">Br J Health Psychol</span>
|
||
2014 Sep;19(3):465-85.
|
||
Epub 2013 Aug 26
|
||
doi: 10.1111/bjhp.12061.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23980690" target="_blank">23980690</a></div>
|
||
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