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<meta name="keywords" content="C1835130, finding, mitral annular calcification, premature calcification of mitral annulus, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Mitral annular calcification (MAC) results from progressive calcium deposition along and beneath the mitral valve annulus." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
|
||
UID=331909
|
||
ConceptID=C1835130
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Mitral annular calcification</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>331909</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1835130</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Premature calcification of mitral annulus</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0005136">HP:0005136</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
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|
||
<div class="portlet_content ln">Mitral annular calcification (MAC) results from progressive calcium deposition along and beneath the mitral valve annulus. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Mitral annular calcification</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/2848" ref="tree=MeSH" title="MedGen record for Disorder of cardiovascular system">Disorder of cardiovascular system</a></span><ul><li><span class="TLline"><a href="/medgen/116727" ref="tree=MeSH" title="MedGen record for Abnormality of the cardiovascular system">Abnormality of the cardiovascular system</a></span><ul><li><span class="TLline"><a href="/medgen/892473" ref="tree=MeSH" title="MedGen record for Abnormal cardiovascular system morphology">Abnormal cardiovascular system morphology</a></span><ul><li><span class="TLline"><a href="/medgen/868723" ref="tree=MeSH" title="MedGen record for Cardiovascular calcification">Cardiovascular calcification</a></span><ul><li><span class="TLline"><a href="/medgen/383924" ref="tree=MeSH" title="MedGen record for Cardiac valve calcification">Cardiac valve calcification</a></span><ul><li><span class="TLline"><a href="/medgen/181575" ref="tree=MeSH" title="MedGen record for Mitral valve calcification">Mitral valve calcification</a></span><ul><li><span class="matched_ds">Mitral annular calcification</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_44287"><div><strong>Marfan syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>44287</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0024796</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">FBN1-related Marfan syndrome (Marfan syndrome), a systemic disorder of connective tissue with a high degree of clinical variability, comprises a broad phenotypic continuum ranging from mild (features of Marfan syndrome in one or a few systems) to severe and rapidly progressive neonatal multiorgan disease. Cardinal manifestations involve the ocular, skeletal, and cardiovascular systems. Ocular findings include myopia (>50% of affected individuals); ectopia lentis (seen in approximately 60% of affected individuals); and an increased risk for retinal detachment, glaucoma, and early cataracts. Skeletal system manifestations include bone overgrowth and joint laxity; disproportionately long extremities for the size of the trunk (dolichostenomelia); overgrowth of the ribs that can push the sternum in (pectus excavatum) or out (pectus carinatum); and scoliosis that ranges from mild to severe and progressive. The major morbidity and early mortality in Marfan syndrome relate to the cardiovascular system and include dilatation of the aorta at the level of the sinuses of Valsalva (predisposing to aortic tear and rupture), mitral valve prolapse with or without regurgitation, tricuspid valve prolapse, and enlargement of the proximal pulmonary artery. Severe and prolonged regurgitation of the mitral and/or aortic valve can predispose to left ventricular dysfunction and occasionally heart failure. With proper management, the life expectancy of someone with Marfan syndrome approximates that of the general population.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/44287">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_44287" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Marfan syndrome</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37758378">Diagnosis, Classification, and Management Strategies for Mitral Annular Calcification: A Heart Valve Collaboratory Position Statement.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Guerrero ME,
|
||
Grayburn P,
|
||
Smith RL 2nd,
|
||
Sorajja P,
|
||
Wang DD,
|
||
Ahmad Y,
|
||
Blusztein D,
|
||
Cavalcante J,
|
||
Tang GHL,
|
||
Ailawadi G,
|
||
Lim DS,
|
||
Blanke P,
|
||
Eleid MF,
|
||
Kaneko T,
|
||
Thourani VH,
|
||
Bapat V,
|
||
Mack MJ,
|
||
Leon MB,
|
||
George I</span><br />
|
||
<span class="medgenPMjournal">JACC Cardiovasc Interv</span>
|
||
2023 Sep 25;16(18):2195-2210.
|
||
doi: 10.1016/j.jcin.2023.06.044.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37758378" target="_blank">37758378</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31895243">Surgical management of mitral annular calcification.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">El-Eshmawi A,
|
||
Alexis SL,
|
||
Sengupta A,
|
||
Pandis D,
|
||
Rimsukcharoenchai C,
|
||
Adams DH,
|
||
Tang GHL</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Cardiol</span>
|
||
2020 Mar;35(2):107-115.
|
||
doi: 10.1097/HCO.0000000000000718.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31895243" target="_blank">31895243</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31587368">Degenerative mitral valve stenosis: Diagnosis and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Al-Taweel A,
|
||
Almahmoud MF,
|
||
Khairandish Y,
|
||
Ahmad M</span><br />
|
||
<span class="medgenPMjournal">Echocardiography</span>
|
||
2019 Oct;36(10):1901-1909.
|
||
Epub 2019 Oct 6
|
||
doi: 10.1111/echo.14495.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31587368" target="_blank">31587368</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22mitral%20annular%20calcification%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (14)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37758379">5-Year Prospective Evaluation of Mitral Valve-in-Valve, Valve-in-Ring, and Valve-in-MAC Outcomes: MITRAL Trial Final Results.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Guerrero ME,
|
||
Eleid MF,
|
||
Wang DD,
|
||
Pursnani A,
|
||
Kodali SK,
|
||
George I,
|
||
Palacios I,
|
||
Russell H,
|
||
Makkar RR,
|
||
Kar S,
|
||
Satler LF,
|
||
Rajagopal V,
|
||
Dangas G,
|
||
Tang GHL,
|
||
McCabe JM,
|
||
Whisenant BK,
|
||
Fang K,
|
||
Balan P,
|
||
Smalling R,
|
||
Kaptzan T,
|
||
Lewis B,
|
||
Douglas PS,
|
||
Hahn RT,
|
||
Thaden J,
|
||
Oh JK,
|
||
Leon M,
|
||
O'Neill W,
|
||
Rihal C</span><br />
|
||
<span class="medgenPMjournal">JACC Cardiovasc Interv</span>
|
||
2023 Sep 25;16(18):2211-2227.
|
||
doi: 10.1016/j.jcin.2023.06.041.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37758379" target="_blank">37758379</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37758378">Diagnosis, Classification, and Management Strategies for Mitral Annular Calcification: A Heart Valve Collaboratory Position Statement.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Guerrero ME,
|
||
Grayburn P,
|
||
Smith RL 2nd,
|
||
Sorajja P,
|
||
Wang DD,
|
||
Ahmad Y,
|
||
Blusztein D,
|
||
Cavalcante J,
|
||
Tang GHL,
|
||
Ailawadi G,
|
||
Lim DS,
|
||
Blanke P,
|
||
Eleid MF,
|
||
Kaneko T,
|
||
Thourani VH,
|
||
Bapat V,
|
||
Mack MJ,
|
||
Leon MB,
|
||
George I</span><br />
|
||
<span class="medgenPMjournal">JACC Cardiovasc Interv</span>
|
||
2023 Sep 25;16(18):2195-2210.
|
||
doi: 10.1016/j.jcin.2023.06.044.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37758378" target="_blank">37758378</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35432730">Paravalvular Leak.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Qamar F,
|
||
Attar RH,
|
||
Nabi F</span><br />
|
||
<span class="medgenPMjournal">Methodist Debakey Cardiovasc J</span>
|
||
2022;18(1):7-9.
|
||
Epub 2022 Apr 1
|
||
doi: 10.14797/mdcvj.1096.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35432730" target="_blank">35432730</a><a href="/pmc/articles/PMC8973757" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31078187">Surgical Transatrial Implantation of Transcatheter Heart Valves in Severe Mitral Annular Calcification.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kassar M,
|
||
Khalique OK,
|
||
Pilgrim T,
|
||
Reineke D,
|
||
Carrel T,
|
||
Windecker S,
|
||
George I,
|
||
Praz F</span><br />
|
||
<span class="medgenPMjournal">Interv Cardiol Clin</span>
|
||
2019 Jul;8(3):313-319.
|
||
Epub 2019 Apr 8
|
||
doi: 10.1016/j.iccl.2019.02.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31078187" target="_blank">31078187</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26493666">Mitral Annulus Calcification.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Abramowitz Y,
|
||
Jilaihawi H,
|
||
Chakravarty T,
|
||
Mack MJ,
|
||
Makkar RR</span><br />
|
||
<span class="medgenPMjournal">J Am Coll Cardiol</span>
|
||
2015 Oct 27;66(17):1934-41.
|
||
doi: 10.1016/j.jacc.2015.08.872.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26493666" target="_blank">26493666</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mitral%20annular%20calcification%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (415)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37758378">Diagnosis, Classification, and Management Strategies for Mitral Annular Calcification: A Heart Valve Collaboratory Position Statement.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Guerrero ME,
|
||
Grayburn P,
|
||
Smith RL 2nd,
|
||
Sorajja P,
|
||
Wang DD,
|
||
Ahmad Y,
|
||
Blusztein D,
|
||
Cavalcante J,
|
||
Tang GHL,
|
||
Ailawadi G,
|
||
Lim DS,
|
||
Blanke P,
|
||
Eleid MF,
|
||
Kaneko T,
|
||
Thourani VH,
|
||
Bapat V,
|
||
Mack MJ,
|
||
Leon MB,
|
||
George I</span><br />
|
||
<span class="medgenPMjournal">JACC Cardiovasc Interv</span>
|
||
2023 Sep 25;16(18):2195-2210.
|
||
doi: 10.1016/j.jcin.2023.06.044.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37758378" target="_blank">37758378</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33172308">Severe Mobile Mitral Annular Calcification Mimicking Vegetation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hu PT,
|
||
Xu B,
|
||
Grimm RA,
|
||
Unai S,
|
||
Miyasaka RL</span><br />
|
||
<span class="medgenPMjournal">Circ Cardiovasc Imaging</span>
|
||
2020 Nov;13(11):e010541.
|
||
Epub 2020 Nov 11
|
||
doi: 10.1161/CIRCIMAGING.120.010541.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33172308" target="_blank">33172308</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32285092">Pseudoxanthoma elasticum and caseous mitral annular calcification: rare association or coincidence?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Scotti A,
|
||
Massussi M,
|
||
Baritussio A,
|
||
Pergola V</span><br />
|
||
<span class="medgenPMjournal">Eur Heart J</span>
|
||
2020 Aug 1;41(29):2817.
|
||
doi: 10.1093/eurheartj/ehaa223.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32285092" target="_blank">32285092</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31403845">Complexity of Defining Severe "Stenosis" From Mitral Annular Calcification.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Reddy YNV,
|
||
Murgo JP,
|
||
Nishimura RA</span><br />
|
||
<span class="medgenPMjournal">Circulation</span>
|
||
2019 Aug 13;140(7):523-525.
|
||
Epub 2019 Aug 12
|
||
doi: 10.1161/CIRCULATIONAHA.119.040095.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31403845" target="_blank">31403845</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26493666">Mitral Annulus Calcification.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Abramowitz Y,
|
||
Jilaihawi H,
|
||
Chakravarty T,
|
||
Mack MJ,
|
||
Makkar RR</span><br />
|
||
<span class="medgenPMjournal">J Am Coll Cardiol</span>
|
||
2015 Oct 27;66(17):1934-41.
|
||
doi: 10.1016/j.jacc.2015.08.872.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26493666" target="_blank">26493666</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mitral%20annular%20calcification%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (278)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38479970">Percutaneous Transeptal Transcatheter Mitral Valve Replacement Following Failed Surgical Edge-to-Edge Repair.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Scotti A,
|
||
Ho EC,
|
||
Echarte-Morales J,
|
||
Sturla M,
|
||
Chau M,
|
||
Joseph CA,
|
||
Slipczuk L,
|
||
Ranard L,
|
||
Vahl TP,
|
||
Granada JF,
|
||
Latib A</span><br />
|
||
<span class="medgenPMjournal">JACC Cardiovasc Interv</span>
|
||
2024 Mar 11;17(5):699-701.
|
||
doi: 10.1016/j.jcin.2024.01.011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38479970" target="_blank">38479970</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37758378">Diagnosis, Classification, and Management Strategies for Mitral Annular Calcification: A Heart Valve Collaboratory Position Statement.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Guerrero ME,
|
||
Grayburn P,
|
||
Smith RL 2nd,
|
||
Sorajja P,
|
||
Wang DD,
|
||
Ahmad Y,
|
||
Blusztein D,
|
||
Cavalcante J,
|
||
Tang GHL,
|
||
Ailawadi G,
|
||
Lim DS,
|
||
Blanke P,
|
||
Eleid MF,
|
||
Kaneko T,
|
||
Thourani VH,
|
||
Bapat V,
|
||
Mack MJ,
|
||
Leon MB,
|
||
George I</span><br />
|
||
<span class="medgenPMjournal">JACC Cardiovasc Interv</span>
|
||
2023 Sep 25;16(18):2195-2210.
|
||
doi: 10.1016/j.jcin.2023.06.044.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37758378" target="_blank">37758378</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35432730">Paravalvular Leak.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Qamar F,
|
||
Attar RH,
|
||
Nabi F</span><br />
|
||
<span class="medgenPMjournal">Methodist Debakey Cardiovasc J</span>
|
||
2022;18(1):7-9.
|
||
Epub 2022 Apr 1
|
||
doi: 10.14797/mdcvj.1096.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35432730" target="_blank">35432730</a><a href="/pmc/articles/PMC8973757" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29681536">Transcatheter mitral valve replacement in severe mitral annular calcification and atrial septal defect closure.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Demir OM,
|
||
Ruparelia N,
|
||
Gopalan D,
|
||
Busi G,
|
||
Frame A,
|
||
Sutaria N,
|
||
Ariff B,
|
||
Sen S,
|
||
Malik I,
|
||
Colombo A,
|
||
Mikhail GW</span><br />
|
||
<span class="medgenPMjournal">Cardiovasc Revasc Med</span>
|
||
2019 Mar;20(3):194-196.
|
||
Epub 2018 Apr 7
|
||
doi: 10.1016/j.carrev.2018.03.022.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29681536" target="_blank">29681536</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28982555">Transseptal Transcatheter Mitral Valve Replacement Using Balloon-Expandable Transcatheter Heart Valves: A Step-by-Step Approach.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Urena M,
|
||
Himbert D,
|
||
Brochet E,
|
||
Carrasco JL,
|
||
Iung B,
|
||
Nataf P,
|
||
Vahanian A</span><br />
|
||
<span class="medgenPMjournal">JACC Cardiovasc Interv</span>
|
||
2017 Oct 9;10(19):1905-1919.
|
||
doi: 10.1016/j.jcin.2017.06.069.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28982555" target="_blank">28982555</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mitral%20annular%20calcification%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (168)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34822847">Mitral Annular Calcification in Obstructive Hypertrophic Cardiomyopathy: Prevalence and Outcomes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Patlolla SH,
|
||
Schaff HV,
|
||
Nishimura RA,
|
||
Geske JB,
|
||
Lahr BD,
|
||
Lee AT,
|
||
Eleid MF,
|
||
Ommen SR,
|
||
Dearani JA</span><br />
|
||
<span class="medgenPMjournal">Ann Thorac Surg</span>
|
||
2022 Nov;114(5):1679-1687.
|
||
Epub 2021 Nov 22
|
||
doi: 10.1016/j.athoracsur.2021.09.077.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34822847" target="_blank">34822847</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33172308">Severe Mobile Mitral Annular Calcification Mimicking Vegetation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hu PT,
|
||
Xu B,
|
||
Grimm RA,
|
||
Unai S,
|
||
Miyasaka RL</span><br />
|
||
<span class="medgenPMjournal">Circ Cardiovasc Imaging</span>
|
||
2020 Nov;13(11):e010541.
|
||
Epub 2020 Nov 11
|
||
doi: 10.1161/CIRCIMAGING.120.010541.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33172308" target="_blank">33172308</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31402089">Mechanisms of mitral annular calcification.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Massera D,
|
||
Kizer JR,
|
||
Dweck MR</span><br />
|
||
<span class="medgenPMjournal">Trends Cardiovasc Med</span>
|
||
2020 Jul;30(5):289-295.
|
||
Epub 2019 Aug 5
|
||
doi: 10.1016/j.tcm.2019.07.011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31402089" target="_blank">31402089</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30141342">Transcatheter aortic valve replacement with the Lotus valve system.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Barker CM,
|
||
Reardon MJ</span><br />
|
||
<span class="medgenPMjournal">Future Cardiol</span>
|
||
2018 Sep;14(5):367-373.
|
||
Epub 2018 Aug 24
|
||
doi: 10.2217/fca-2018-0044.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30141342" target="_blank">30141342</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28004210">Exuberant mitral annular calcification.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lyle MA,
|
||
Snipelisky DF,
|
||
Aggarwal NR,
|
||
Miller FA,
|
||
Anavekar NS</span><br />
|
||
<span class="medgenPMjournal">Int J Cardiovasc Imaging</span>
|
||
2017 May;33(5):615-621.
|
||
Epub 2016 Dec 22
|
||
doi: 10.1007/s10554-016-1043-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28004210" target="_blank">28004210</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mitral%20annular%20calcification%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (255)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37758379">5-Year Prospective Evaluation of Mitral Valve-in-Valve, Valve-in-Ring, and Valve-in-MAC Outcomes: MITRAL Trial Final Results.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Guerrero ME,
|
||
Eleid MF,
|
||
Wang DD,
|
||
Pursnani A,
|
||
Kodali SK,
|
||
George I,
|
||
Palacios I,
|
||
Russell H,
|
||
Makkar RR,
|
||
Kar S,
|
||
Satler LF,
|
||
Rajagopal V,
|
||
Dangas G,
|
||
Tang GHL,
|
||
McCabe JM,
|
||
Whisenant BK,
|
||
Fang K,
|
||
Balan P,
|
||
Smalling R,
|
||
Kaptzan T,
|
||
Lewis B,
|
||
Douglas PS,
|
||
Hahn RT,
|
||
Thaden J,
|
||
Oh JK,
|
||
Leon M,
|
||
O'Neill W,
|
||
Rihal C</span><br />
|
||
<span class="medgenPMjournal">JACC Cardiovasc Interv</span>
|
||
2023 Sep 25;16(18):2211-2227.
|
||
doi: 10.1016/j.jcin.2023.06.041.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37758379" target="_blank">37758379</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34822847">Mitral Annular Calcification in Obstructive Hypertrophic Cardiomyopathy: Prevalence and Outcomes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Patlolla SH,
|
||
Schaff HV,
|
||
Nishimura RA,
|
||
Geske JB,
|
||
Lahr BD,
|
||
Lee AT,
|
||
Eleid MF,
|
||
Ommen SR,
|
||
Dearani JA</span><br />
|
||
<span class="medgenPMjournal">Ann Thorac Surg</span>
|
||
2022 Nov;114(5):1679-1687.
|
||
Epub 2021 Nov 22
|
||
doi: 10.1016/j.athoracsur.2021.09.077.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34822847" target="_blank">34822847</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33172308">Severe Mobile Mitral Annular Calcification Mimicking Vegetation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hu PT,
|
||
Xu B,
|
||
Grimm RA,
|
||
Unai S,
|
||
Miyasaka RL</span><br />
|
||
<span class="medgenPMjournal">Circ Cardiovasc Imaging</span>
|
||
2020 Nov;13(11):e010541.
|
||
Epub 2020 Nov 11
|
||
doi: 10.1161/CIRCIMAGING.120.010541.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33172308" target="_blank">33172308</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28004210">Exuberant mitral annular calcification.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lyle MA,
|
||
Snipelisky DF,
|
||
Aggarwal NR,
|
||
Miller FA,
|
||
Anavekar NS</span><br />
|
||
<span class="medgenPMjournal">Int J Cardiovasc Imaging</span>
|
||
2017 May;33(5):615-621.
|
||
Epub 2016 Dec 22
|
||
doi: 10.1007/s10554-016-1043-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28004210" target="_blank">28004210</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27832900">Severe Mitral Annular Calcification: Multimodality Imaging for Therapeutic Strategies and Interventions.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Eleid MF,
|
||
Foley TA,
|
||
Said SM,
|
||
Pislaru SV,
|
||
Rihal CS</span><br />
|
||
<span class="medgenPMjournal">JACC Cardiovasc Imaging</span>
|
||
2016 Nov;9(11):1318-1337.
|
||
doi: 10.1016/j.jcmg.2016.09.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27832900" target="_blank">27832900</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mitral%20annular%20calcification%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (253)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/37385163">A Systematic Review and Meta-Analysis of Prevalence, Characteristics, and Impact of Mitral Annular Calcification on Outcomes After Transcatheter Aortic Valve Implantation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Moin A,
|
||
Lak HM,
|
||
Zafar M,
|
||
Tariq R,
|
||
Shaikh FH,
|
||
Mussa M,
|
||
Bansal A,
|
||
Shekhar S,
|
||
Harb S,
|
||
Unai S,
|
||
Kapadia SR</span><br />
|
||
<span class="medgenPMjournal">Am J Cardiol</span>
|
||
2023 Aug 15;201:123-130.
|
||
Epub 2023 Jun 27
|
||
doi: 10.1016/j.amjcard.2023.05.069.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37385163" target="_blank">37385163</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36538998">Mitral Annular Calcification Related Infective Endocarditis: A Contemporary Systematic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kumar A,
|
||
Samra G,
|
||
Kaur S,
|
||
Ogunnowo G,
|
||
Kocyigit D,
|
||
Xu B</span><br />
|
||
<span class="medgenPMjournal">Curr Probl Cardiol</span>
|
||
2023 Mar;48(3):101558.
|
||
Epub 2022 Dec 18
|
||
doi: 10.1016/j.cpcardiol.2022.101558.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36538998" target="_blank">36538998</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33728929">Surgical and Transcatheter Mitral Valve Replacement in Mitral Annular Calcification: A Systematic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Alexis SL,
|
||
Malik AH,
|
||
El-Eshmawi A,
|
||
George I,
|
||
Sengupta A,
|
||
Kodali SK,
|
||
Hahn RT,
|
||
Khalique OK,
|
||
Zaid S,
|
||
Guerrero M,
|
||
Bapat VN,
|
||
Leon MB,
|
||
Adams DH,
|
||
Tang GHL</span><br />
|
||
<span class="medgenPMjournal">J Am Heart Assoc</span>
|
||
2021 Apr 6;10(7):e018514.
|
||
Epub 2021 Mar 17
|
||
doi: 10.1161/JAHA.120.018514.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33728929" target="_blank">33728929</a><a href="/pmc/articles/PMC8174336" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33687594">Transcatheter Mitral Valve Implantation Systematic Review: Focus on Transseptal Approach and Mitral Annulus Calcification.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ben-Ali W,
|
||
Ibrahim R,
|
||
Rodès-Cabeau J,
|
||
von Bardeleben RS,
|
||
Mylotte D,
|
||
Granada J,
|
||
Modine T</span><br />
|
||
<span class="medgenPMjournal">Curr Cardiol Rep</span>
|
||
2021 Mar 9;23(4):37.
|
||
doi: 10.1007/s11886-021-01466-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33687594" target="_blank">33687594</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26577250">Transcatheter mitral valve implantation for inoperable severely calcified native mitral valve disease: A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Puri R,
|
||
Abdul-Jawad Altisent O,
|
||
del Trigo M,
|
||
Campelo-Parada F,
|
||
Regueiro A,
|
||
Barbosa Ribeiro H,
|
||
DeLarochellière R,
|
||
Paradis JM,
|
||
Dumont E,
|
||
Rodés-Cabau J</span><br />
|
||
<span class="medgenPMjournal">Catheter Cardiovasc Interv</span>
|
||
2016 Feb 15;87(3):540-8.
|
||
Epub 2015 Nov 18
|
||
doi: 10.1002/ccd.26262.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26577250" target="_blank">26577250</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mitral%20annular%20calcification%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (9)</a></div></div>
|
||
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|
||
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22mitral%20annular%20calcification%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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