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<!--
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UID=326597
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ConceptID=C1839866
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Elevated serum acid phosphatase</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>326597</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1839866</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
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<td>Acid phosphatase elevated</td></tr>
|
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<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0003148">HP:0003148</a></td></tr>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Elevated serum acid phosphatase</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/1369113" ref="tree=MeSH" title="MedGen record for Abnormal cellular phenotype">Abnormal cellular phenotype</a></span><ul><li><span class="TLline"><a href="/medgen/869173" ref="tree=MeSH" title="MedGen record for Abnormal cellular physiology">Abnormal cellular physiology</a></span><ul><li><span class="TLline"><a href="/medgen/870881" ref="tree=MeSH" title="MedGen record for Abnormality of lysosomal metabolism">Abnormality of lysosomal metabolism</a></span><ul><li><span class="matched_ds">Elevated serum acid phosphatase</span></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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<div class="divPopper rprt" id="rdis_18145"><div><strong>Lowe syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>18145</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0028860</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Lowe syndrome (oculocerebrorenal syndrome) is characterized by involvement of the eyes, central nervous system, and kidneys. Dense congenital cataracts are found in all affected boys and infantile glaucoma in approximately 50%. All boys have impaired vision; corrected acuity is rarely better than 20/100. Generalized hypotonia is noted at birth and is of central (brain) origin. Deep tendon reflexes are usually absent. Hypotonia may slowly improve with age, but normal motor tone and strength are never achieved. Motor milestones are delayed. Almost all affected males have some degree of intellectual disability; 10%-25% function in the low-normal or borderline range, approximately 25% in the mild-to-moderate range, and 50%-65% in the severe-to-profound range of intellectual disability. Affected males have varying degrees of proximal renal tubular dysfunction of the Fanconi type, including low molecular-weight (LMW) proteinuria, aminoaciduria, bicarbonate wasting and renal tubular acidosis, phosphaturia with hypophosphatemia and renal rickets, hypercalciuria, sodium and potassium wasting, and polyuria. The features of symptomatic Fanconi syndrome do not usually become manifest until after the first few months of life, except for LMW proteinuria. Glomerulosclerosis associated with chronic tubular injury usually results in slowly progressive chronic renal failure and end-stage renal disease between the second and fourth decades of life.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/18145">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_75678"><div><strong>Hyperphosphatasemia with bone disease</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>75678</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0268414</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Paget disease of bone-5 is an autosomal recessive, juvenile-onset form of Paget disease, a disorder of the skeleton resulting from abnormal bone resorption and formation. Clinical manifestations include short stature, progressive long bone deformities, fractures, vertebral collapse, skull enlargement, and hyperostosis with progressive deafness. There is phenotypic variability, with some patients presenting in infancy, while others present later in childhood (summary by Naot et al., 2014). For discussion of genetic heterogeneity of Paget disease of bone, see 167250.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/75678">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_91042"><div><strong>Osteopetrosis with renal tubular acidosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>91042</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0345407</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Osteopetrosis is a bone disease that makes bone tissue abnormally compact and dense and also prone to breakage (fracture). Researchers have described several major types of osteopetrosis, which are usually distinguished by their pattern of inheritance: autosomal dominant or autosomal recessive. The different types of the disorder can also be distinguished by the severity of their signs and symptoms.\n\nAutosomal dominant osteopetrosis (ADO), which is also called Albers-Schönberg disease, is typically the mildest type of the disorder. Some affected individuals have no symptoms. In affected people with no symptoms, the unusually dense bones may be discovered by accident when an x-ray is done for another reason. \n\nIn individuals with ADO who develop signs and symptoms, the major features of the condition include multiple bone fractures after minor injury, abnormal side-to-side curvature of the spine (scoliosis) or other spinal abnormalities, arthritis in the hips, and a bone infection called osteomyelitis. These problems usually become apparent in late childhood or adolescence.\n\nAutosomal recessive osteopetrosis (ARO) is a more severe form of the disorder that becomes apparent in early infancy. Affected individuals have a high risk of bone fracture resulting from seemingly minor bumps and falls. Their abnormally dense skull bones pinch nerves in the head and face (cranial nerves), often resulting in vision loss, hearing loss, and paralysis of facial muscles. Dense bones can also impair the function of bone marrow, preventing it from producing new blood cells and immune system cells. As a result, people with severe osteopetrosis are at risk of abnormal bleeding, a shortage of red blood cells (anemia), and recurrent infections. In the most severe cases, these bone marrow abnormalities can be life-threatening in infancy or early childhood.\n\nOther features of autosomal recessive osteopetrosis can include slow growth and short stature, dental abnormalities, and an enlarged liver and spleen (hepatosplenomegaly). Depending on the genetic changes involved, people with severe osteopetrosis can also have brain abnormalities, intellectual disability, or recurrent seizures (epilepsy).\n\nA few individuals have been diagnosed with intermediate autosomal osteopetrosis (IAO), a form of the disorder that can have either an autosomal dominant or an autosomal recessive pattern of inheritance. The signs and symptoms of this condition become noticeable in childhood and include an increased risk of bone fracture and anemia. People with this form of the disorder typically do not have life-threatening bone marrow abnormalities. However, some affected individuals have had abnormal calcium deposits (calcifications) in the brain, intellectual disability, and a form of kidney disease called renal tubular acidosis.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/91042">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_335932"><div><strong>Autosomal dominant osteopetrosis 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>335932</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1843330</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The osteopetroses are a heterogeneous group of genetic disorders characterized by increased bone density due to impaired bone resorption by osteoclasts. Autosomal dominant osteopetrosis-1 (OPTA1) is characterized by generalized osteosclerosis most pronounced in the cranial vault. Patients are often asymptomatic, but some suffer from pain and hearing loss. It appears to be the only type of osteopetrosis not associated with an increased fracture rate (summary by Van Hul et al., 2002). Genetic Heterogeneity of Autosomal Dominant Osteopetrosis Autosomal dominant osteopetrosis-2 (OPTA2; 166600) is caused by mutation in the CLCN7 gene (602727) on chromosome 16p13. Autosomal dominant osteopetrosis-3 (OPTA3; 618107) is caused by mutation in the PLEKHM1 gene (611466) on chromosome 17q21.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/335932">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_350479"><div><strong>Gaucher disease due to saposin C deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>350479</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1864651</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Any Gaucher disease in which the cause of the disease is a mutation in the PSAP gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/350479">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_465707"><div><strong>Autosomal dominant osteopetrosis 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>465707</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3179239</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The spectrum of CLCN7-related osteopetrosis includes infantile malignant CLCN7-related autosomal recessive osteopetrosis (ARO), intermediate autosomal osteopetrosis (IAO), and autosomal dominant osteopetrosis type II (ADOII; Albers-Schönberg disease). ARO. Onset is at birth. Findings may include: fractures; reduced growth; sclerosis of the skull base (with or without choanal stenosis or hydrocephalus) resulting in optic nerve compression, facial palsy, and hearing loss; absence of the bone marrow cavity resulting in severe anemia and thrombocytopenia; dental abnormalities, odontomas, and risk for mandibular osteomyelitis; and hypocalcemia with tetanic seizures and secondary hyperparathyroidism. Without treatment maximal life span in ARO is ten years. IAO. Onset is in childhood. Findings may include: fractures after minor trauma, characteristic skeletal radiographic changes found incidentally, mild anemia, and occasional visual impairment secondary to optic nerve compression. Life expectancy in IAO is usually normal. ADOII. Onset is usually late childhood or adolescence. Findings may include: fractures (in any long bone and/or the posterior arch of a vertebra), scoliosis, hip osteoarthritis, and osteomyelitis of the mandible or septic osteitis or osteoarthritis elsewhere. Cranial nerve compression is rare.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/465707">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_335932" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal dominant osteopetrosis 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_465707" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal dominant osteopetrosis 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_350479" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Gaucher disease due to saposin C deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_75678" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hyperphosphatasemia with bone disease</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_18145" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Lowe syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_91042" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Osteopetrosis with renal tubular acidosis</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/7684112">Surveillance of patients with prostate cancer after treatment: the roles of serologic and imaging studies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kagan AR,
|
||
Steckel RJ</span><br />
|
||
<span class="medgenPMjournal">Med Pediatr Oncol</span>
|
||
1993;21(5):327-32.
|
||
doi: 10.1002/mpo.2950210504.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7684112" target="_blank">7684112</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6512929">Early detection of prostate cancer by routine screening.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chodak GW,
|
||
Schoenberg HW</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
1984 Dec 21;252(23):3261-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6512929" target="_blank">6512929</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22elevated%20serum%20acid%20phosphatase%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (2)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/3047336">Androgen priming and chemotherapy in advanced prostate cancer: evaluation of determinants of clinical outcome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Manni A,
|
||
Bartholomew M,
|
||
Caplan R,
|
||
Boucher A,
|
||
Santen R,
|
||
Lipton A,
|
||
Harvey H,
|
||
Simmonds M,
|
||
White-Hershey D,
|
||
Gordon R</span><br />
|
||
<span class="medgenPMjournal">J Clin Oncol</span>
|
||
1988 Sep;6(9):1456-66.
|
||
doi: 10.1200/JCO.1988.6.9.1456.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3047336" target="_blank">3047336</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3840406">Malignant lymphomas involving the prostate. A study of 13 cases.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bostwick DG,
|
||
Mann RB</span><br />
|
||
<span class="medgenPMjournal">Cancer</span>
|
||
1985 Dec 15;56(12):2932-8.
|
||
doi: 10.1002/1097-0142(19851215)56:12<2932::aid-cncr2820561234>3.0.co;2-h.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3840406" target="_blank">3840406</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6512929">Early detection of prostate cancer by routine screening.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chodak GW,
|
||
Schoenberg HW</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
1984 Dec 21;252(23):3261-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6512929" target="_blank">6512929</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7123159">Comparison of radioimmunological and conventional acid phosphatase assays in the serum of prostatic cancer patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vihko P,
|
||
Jokipalo A,
|
||
Tenhunen R,
|
||
Alfthan O,
|
||
Oravisto KJ</span><br />
|
||
<span class="medgenPMjournal">Scand J Urol Nephrol</span>
|
||
1982;16(2):105-8.
|
||
doi: 10.3109/00365598209179737.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7123159" target="_blank">7123159</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/183594">The specificity and nature of serum-angiotensin-converting enzyme (serum ACE) elevations in sarcoidosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lieberman J</span><br />
|
||
<span class="medgenPMjournal">Ann N Y Acad Sci</span>
|
||
1976;278:488-97.
|
||
doi: 10.1111/j.1749-6632.1976.tb47061.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/183594" target="_blank">183594</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Elevated%20serum%20acid%20phosphatase%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (9)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/6512929">Early detection of prostate cancer by routine screening.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chodak GW,
|
||
Schoenberg HW</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
1984 Dec 21;252(23):3261-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6512929" target="_blank">6512929</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6960189">Elevated serum acid phosphatase in chronic myelomonocytic leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stefaniwsky AB,
|
||
Kim HC,
|
||
Cho YM,
|
||
Saidi P</span><br />
|
||
<span class="medgenPMjournal">J Med Soc N J</span>
|
||
1982 Nov;79(12):915-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6960189" target="_blank">6960189</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/941359">Pre- and postejaculation serum acid phosphatase.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Khan RM,
|
||
Cromie WJ,
|
||
Edson M</span><br />
|
||
<span class="medgenPMjournal">Urology</span>
|
||
1976 Jul;8(1):43-5.
|
||
doi: 10.1016/0090-4295(76)90051-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/941359" target="_blank">941359</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/183594">The specificity and nature of serum-angiotensin-converting enzyme (serum ACE) elevations in sarcoidosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lieberman J</span><br />
|
||
<span class="medgenPMjournal">Ann N Y Acad Sci</span>
|
||
1976;278:488-97.
|
||
doi: 10.1111/j.1749-6632.1976.tb47061.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/183594" target="_blank">183594</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/14181144">GAUCHER'S DISEASE (WITH ELEVATED SERUM ACID PHOSPHATASE LEVEL) MASQUERADING AS CIRRHOSIS OF THE LIVER.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">TYSON MC,
|
||
GROSSMAN WI,
|
||
TUCHMAN LR</span><br />
|
||
<span class="medgenPMjournal">Am J Med</span>
|
||
1964 Jul;37:156-8.
|
||
doi: 10.1016/0002-9343(64)90220-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/14181144" target="_blank">14181144</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Elevated%20serum%20acid%20phosphatase%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (12)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/3047336">Androgen priming and chemotherapy in advanced prostate cancer: evaluation of determinants of clinical outcome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Manni A,
|
||
Bartholomew M,
|
||
Caplan R,
|
||
Boucher A,
|
||
Santen R,
|
||
Lipton A,
|
||
Harvey H,
|
||
Simmonds M,
|
||
White-Hershey D,
|
||
Gordon R</span><br />
|
||
<span class="medgenPMjournal">J Clin Oncol</span>
|
||
1988 Sep;6(9):1456-66.
|
||
doi: 10.1200/JCO.1988.6.9.1456.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3047336" target="_blank">3047336</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3840406">Malignant lymphomas involving the prostate. A study of 13 cases.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bostwick DG,
|
||
Mann RB</span><br />
|
||
<span class="medgenPMjournal">Cancer</span>
|
||
1985 Dec 15;56(12):2932-8.
|
||
doi: 10.1002/1097-0142(19851215)56:12<2932::aid-cncr2820561234>3.0.co;2-h.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3840406" target="_blank">3840406</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7230488">Unpredictable fluctuations in serum acid phosphatase activity in prostatic cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brenckman WD Jr,
|
||
Lastinger LB,
|
||
Sedor F</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
1981 Jun 26;245(24):2501-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7230488" target="_blank">7230488</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/65817">Microscopic foci of cancer in prostatectomy for benign disease: diagnostic and surgical considerations.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Makhyoun NA,
|
||
Veenema RJ,
|
||
Wechsler M</span><br />
|
||
<span class="medgenPMjournal">Urology</span>
|
||
1977 Feb;9(2):140-3.
|
||
doi: 10.1016/0090-4295(77)90183-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/65817" target="_blank">65817</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/183594">The specificity and nature of serum-angiotensin-converting enzyme (serum ACE) elevations in sarcoidosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lieberman J</span><br />
|
||
<span class="medgenPMjournal">Ann N Y Acad Sci</span>
|
||
1976;278:488-97.
|
||
doi: 10.1111/j.1749-6632.1976.tb47061.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/183594" target="_blank">183594</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Elevated%20serum%20acid%20phosphatase%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/7684112">Surveillance of patients with prostate cancer after treatment: the roles of serologic and imaging studies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kagan AR,
|
||
Steckel RJ</span><br />
|
||
<span class="medgenPMjournal">Med Pediatr Oncol</span>
|
||
1993;21(5):327-32.
|
||
doi: 10.1002/mpo.2950210504.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7684112" target="_blank">7684112</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3047336">Androgen priming and chemotherapy in advanced prostate cancer: evaluation of determinants of clinical outcome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Manni A,
|
||
Bartholomew M,
|
||
Caplan R,
|
||
Boucher A,
|
||
Santen R,
|
||
Lipton A,
|
||
Harvey H,
|
||
Simmonds M,
|
||
White-Hershey D,
|
||
Gordon R</span><br />
|
||
<span class="medgenPMjournal">J Clin Oncol</span>
|
||
1988 Sep;6(9):1456-66.
|
||
doi: 10.1200/JCO.1988.6.9.1456.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3047336" target="_blank">3047336</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3946039">Invasive carcinoma of prostate presenting as rectal carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Siegel AL,
|
||
Tomaszewski JE,
|
||
Wein AJ,
|
||
Hanno PM</span><br />
|
||
<span class="medgenPMjournal">Urology</span>
|
||
1986 Feb;27(2):162-4.
|
||
doi: 10.1016/0090-4295(86)90375-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3946039" target="_blank">3946039</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3840406">Malignant lymphomas involving the prostate. A study of 13 cases.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bostwick DG,
|
||
Mann RB</span><br />
|
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<span class="medgenPMjournal">Cancer</span>
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1985 Dec 15;56(12):2932-8.
|
||
doi: 10.1002/1097-0142(19851215)56:12<2932::aid-cncr2820561234>3.0.co;2-h.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3840406" target="_blank">3840406</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/13346830">The prognostic significance of an elevated serum acid phosphatase level in advanced prostatic carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">GANEM EJ</span><br />
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<span class="medgenPMjournal">J Urol</span>
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1956 Aug;76(2):179-81.
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doi: 10.1016/S0022-5347(17)66679-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/13346830" target="_blank">13346830</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Elevated%20serum%20acid%20phosphatase%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (8)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/7645138">Prognostic factors in disseminated prostatic cancer, with special emphasis on extent of disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Waaler G,
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Nilssen MO</span><br />
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<span class="medgenPMjournal">Urol Int</span>
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1994;53(3):130-4.
|
||
doi: 10.1159/000282653.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7645138" target="_blank">7645138</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1399729">The prognostic significance of race and survival from prostate cancer based on patients irradiated on Radiation Therapy Oncology Group protocols (1976-1985).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Roach M 3rd,
|
||
Krall J,
|
||
Keller JW,
|
||
Perez CA,
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||
Sause WT,
|
||
Doggett RL,
|
||
Rotman M,
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||
Russ H,
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||
Pilepich MV,
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Asbell SO</span><br />
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<span class="medgenPMjournal">Int J Radiat Oncol Biol Phys</span>
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||
1992;24(3):441-9.
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||
doi: 10.1016/0360-3016(92)91058-u.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1399729" target="_blank">1399729</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3047336">Androgen priming and chemotherapy in advanced prostate cancer: evaluation of determinants of clinical outcome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Manni A,
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Bartholomew M,
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Caplan R,
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Boucher A,
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Santen R,
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Lipton A,
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Harvey H,
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Simmonds M,
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White-Hershey D,
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<span class="medgenPMjournal">J Clin Oncol</span>
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1988 Sep;6(9):1456-66.
|
||
doi: 10.1200/JCO.1988.6.9.1456.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3047336" target="_blank">3047336</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7123159">Comparison of radioimmunological and conventional acid phosphatase assays in the serum of prostatic cancer patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vihko P,
|
||
Jokipalo A,
|
||
Tenhunen R,
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||
Alfthan O,
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Oravisto KJ</span><br />
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<span class="medgenPMjournal">Scand J Urol Nephrol</span>
|
||
1982;16(2):105-8.
|
||
doi: 10.3109/00365598209179737.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7123159" target="_blank">7123159</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7230488">Unpredictable fluctuations in serum acid phosphatase activity in prostatic cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brenckman WD Jr,
|
||
Lastinger LB,
|
||
Sedor F</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
1981 Jun 26;245(24):2501-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7230488" target="_blank">7230488</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Elevated%20serum%20acid%20phosphatase%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5)</a></div></div>
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