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<!--
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UID=326521
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ConceptID=C1839531
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Protein avoidance</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>326521</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1839531</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>HPO:</td>
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0002038">HP:0002038</a></td></tr>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Protein avoidance</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/3828" ref="tree=MeSH" title="MedGen record for Disorder of digestive system">Disorder of digestive system</a></span><ul><li><span class="TLline"><a href="/medgen/78584" ref="tree=MeSH" title="MedGen record for Abnormality of the digestive system">Abnormality of the digestive system</a></span><ul><li><span class="TLline"><a href="/medgen/927601" ref="tree=MeSH" title="MedGen record for Abnormality of digestive system physiology">Abnormality of digestive system physiology</a></span><ul><li><span class="TLline"><a href="/medgen/488929" ref="tree=MeSH" title="MedGen record for Abdominal symptom">Abdominal symptom</a></span><ul><li><span class="matched_ds">Protein avoidance</span></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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<div class="divPopper rprt" id="rdis_82815"><div><strong>Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>82815</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0268540</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome is a disorder of the urea cycle and ornithine degradation pathway. Clinical manifestations and age of onset vary among individuals even in the same family. Neonatal onset (~8% of affected individuals). Manifestations of hyperammonemia usually begin 24-48 hours after feeding begins and can include lethargy, somnolence, refusal to feed, vomiting, tachypnea with respiratory alkalosis, and/or seizures. Infantile, childhood, and adult onset (~92%). Affected individuals may present with: Chronic neurocognitive deficits (including developmental delay, ataxia, spasticity, learning disabilities, cognitive deficits, and/or unexplained seizures); Acute encephalopathy secondary to hyperammonemic crisis precipitated by a variety of factors; and Chronic liver dysfunction (unexplained elevation of liver transaminases with or without mild coagulopathy, with or without mild hyperammonemia and protein intolerance). Neurologic findings and cognitive abilities can continue to deteriorate despite early metabolic control that prevents hyperammonemia.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/82815">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_75692"><div><strong>Ornithine carbamoyltransferase deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>75692</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0268542</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Ornithine transcarbamylase (OTC) deficiency can occur as a severe neonatal-onset disease in males (but rarely in females) and as a post-neonatal-onset (also known as "late-onset" or partial deficiency) disease in males and females. Males with severe neonatal-onset OTC deficiency are asymptomatic at birth but become symptomatic from hyperammonemia in the first week of life, most often on day two to three of life, and are usually catastrophically ill by the time they come to medical attention. After successful treatment of neonatal hyperammonemic coma these infants can easily become hyperammonemic again despite appropriate treatment; they typically require liver transplant to improve quality of life. Males and heterozygous females with post-neonatal-onset (partial) OTC deficiency can present from infancy to later childhood, adolescence, or adulthood. No matter how mild the disease, a hyperammonemic crisis can be precipitated by stressors and become a life-threatening event at any age and in any situation in life. For all individuals with OTC deficiency, typical neuropsychological complications include developmental delay, learning disabilities, intellectual disability, attention-deficit/hyperactivity disorder, and executive function deficits.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/75692">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_78687"><div><strong>Argininosuccinate lyase deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>78687</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0268547</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Deficiency of argininosuccinate lyase (ASL), the enzyme that cleaves argininosuccinic acid to produce arginine and fumarate in the fourth step of the urea cycle, may present as a severe neonatal-onset form or a late-onset form: The severe neonatal-onset form is characterized by hyperammonemia within the first few days after birth that can manifest as increasing lethargy, somnolence, refusal to feed, vomiting, tachypnea, and respiratory alkalosis. Absence of treatment leads to worsening lethargy, seizures, coma, and even death. In contrast, the manifestations of late-onset form range from episodic hyperammonemia triggered by acute infection or stress to cognitive impairment, behavioral abnormalities, and/or learning disabilities in the absence of any documented episodes of hyperammonemia. Manifestations of ASL deficiency that appear to be unrelated to the severity or duration of hyperammonemic episodes: Neurocognitive deficiencies (attention-deficit/hyperactivity disorder, developmental delay, seizures, and learning disability). Liver disease (hepatitis, cirrhosis). Trichorrhexis nodosa (coarse brittle hair that breaks easily). Systemic hypertension.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/78687">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_75704"><div><strong>Lysinuric protein intolerance</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>75704</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0268647</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Lysinuric protein intolerance (LPI) typically presents after an infant is weaned from breast milk or formula; variable findings include recurrent vomiting and episodes of diarrhea, episodes of stupor and coma after a protein-rich meal, poor feeding, aversion to protein-rich food, failure to thrive, hepatosplenomegaly, and muscular hypotonia. Over time, findings include: poor growth, osteoporosis, involvement of the lungs (progressive interstitial changes, pulmonary alveolar proteinosis) and of the kidneys (progressive glomerular and proximal tubular disease), hematologic abnormalities (normochromic or hypochromic anemia, leukopenia, thrombocytopenia, erythroblastophagocytosis in the bone marrow aspirate), and a clinical presentation resembling the hemophagocytic lymphohistiocytosis/macrophagic activation syndrome. Hypercholesterolemia, hypertriglyceridemia, and acute pancreatitis can also be seen.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/75704">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_907954"><div><strong>Congenital hyperammonemia, type I</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>907954</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4082171</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Carbamoyl phosphate synthetase I deficiency is an autosomal recessive inborn error of metabolism of the urea cycle which causes hyperammonemia. There are 2 main forms: a lethal neonatal type and a less severe, delayed-onset type (summary by Klaus et al., 2009). Urea cycle disorders are characterized by the triad of hyperammonemia, encephalopathy, and respiratory alkalosis. Five disorders involving different defects in the biosynthesis of the enzymes of the urea cycle have been described: ornithine transcarbamylase deficiency (311250), carbamyl phosphate synthetase deficiency, argininosuccinate synthetase deficiency, or citrullinemia (215700), argininosuccinate lyase deficiency (207900), and arginase deficiency (207800).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/907954">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1648491"><div><strong>Citrullinemia type I</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1648491</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4721769</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Citrullinemia type I (CTLN1) presents as a spectrum that includes a neonatal acute form (the "classic" form), a milder late-onset form (the "non-classic" form), a form in which women have onset of symptoms at pregnancy or post partum, and a form without symptoms or hyperammonemia. Distinction between the forms is based primarily on clinical findings, although emerging evidence suggests that measurement of residual argininosuccinate synthase enzyme activity may help to predict those who are likely to have a severe phenotype and those who are likely to have an attenuated phenotype. Infants with the acute neonatal form appear normal at birth. Shortly thereafter, they develop hyperammonemia and become progressively lethargic, feed poorly, often vomit, and may develop signs of increased intracranial pressure (ICP). Without prompt intervention, hyperammonemia and the accumulation of other toxic metabolites (e.g., glutamine) result in increased ICP, increased neuromuscular tone, spasticity, ankle clonus, seizures, loss of consciousness, and death. Children with the severe form who are treated promptly may survive for an indeterminate period of time, but usually with significant neurologic deficits. Even with chronic protein restriction and scavenger therapy, long-term complications such as liver failure and other (rarely reported) organ system manifestations are possible. The late-onset form may be milder than that seen in the acute neonatal form, but commences later in life for reasons that are not completely understood. The episodes of hyperammonemia are similar to those seen in the acute neonatal form, but the initial neurologic findings may be more subtle because of the older age of the affected individuals. Women with onset of severe symptoms including acute hepatic decompensation during pregnancy or in the postpartum period have been reported. Furthermore, previously asymptomatic and non-pregnant individuals have been described who remained asymptomatic up to at least age ten years, with the possibility that they could remain asymptomatic lifelong.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1648491">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_78687" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Argininosuccinate lyase deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1648491" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Citrullinemia type I</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_907954" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Congenital hyperammonemia, type I</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_82815" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_75704" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Lysinuric protein intolerance</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_75692" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ornithine carbamoyltransferase deficiency</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/7999460">Nonhormonal alternatives for the management of early menopause in younger women with breast cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bachmann GA</span><br />
|
||
<span class="medgenPMjournal">J Natl Cancer Inst Monogr</span>
|
||
1994;(16):161-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7999460" target="_blank">7999460</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22protein%20avoidance%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (1)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/26194477">Half of the children who received oral immunotherapy for a cows' milk allergy consumed milk freely after 2.5 years.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kivistö JE,
|
||
Korppi M,
|
||
Helminen M,
|
||
Mäki T,
|
||
Paassilta M</span><br />
|
||
<span class="medgenPMjournal">Acta Paediatr</span>
|
||
2015 Nov;104(11):1164-8.
|
||
Epub 2015 Sep 3
|
||
doi: 10.1111/apa.13131.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26194477" target="_blank">26194477</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17636737">WITHDRAWN: Cow's milk protein avoidance and development of childhood wheeze in children with a family history of atopy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ram FS,
|
||
Ducharme FM,
|
||
Scarlett J</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2007 Jul 18;2007(2):CD003795.
|
||
doi: 10.1002/14651858.CD003795.pub2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17636737" target="_blank">17636737</a><a href="/pmc/articles/PMC10680424" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12514690">Late-onset presentation of ornithine transcarbamylase deficiency in a young woman with hyperammonemic coma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gaspari R,
|
||
Arcangeli A,
|
||
Mensi S,
|
||
Wismayer DS,
|
||
Tartaglione T,
|
||
Antuzzi D,
|
||
Conti G,
|
||
Proietti R</span><br />
|
||
<span class="medgenPMjournal">Ann Emerg Med</span>
|
||
2003 Jan;41(1):104-9.
|
||
doi: 10.1067/mem.2003.6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12514690" target="_blank">12514690</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12137717">Cow's milk protein avoidance and development of childhood wheeze in children with a family history of atopy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ram FS,
|
||
Ducharme FM,
|
||
Scarlett J</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2002;(3):CD003795.
|
||
doi: 10.1002/14651858.CD003795.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12137717" target="_blank">12137717</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7999460">Nonhormonal alternatives for the management of early menopause in younger women with breast cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bachmann GA</span><br />
|
||
<span class="medgenPMjournal">J Natl Cancer Inst Monogr</span>
|
||
1994;(16):161-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7999460" target="_blank">7999460</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Protein%20avoidance%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39293417">Lysinuric Protein Intolerance: Not Only a Disorder for Pediatric Nephrologists - Case Report.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rigoldi M,
|
||
Mele C,
|
||
Breno M,
|
||
Noris M,
|
||
Imeraj A,
|
||
Gamba S,
|
||
Schieppati A,
|
||
Daina E;
|
||
Italian Undiagnosed Rare Diseases Network (IURDN)</span><br />
|
||
<span class="medgenPMjournal">Nephron</span>
|
||
2025;149(2):116-124.
|
||
Epub 2024 Sep 18
|
||
doi: 10.1159/000541363.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39293417" target="_blank">39293417</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32688360">Psychiatric Symptoms as the First or Solitary Manifestation of Somatic Illnesses: Hyperammonaemia Type II.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Niwinski P,
|
||
Remberk B,
|
||
Rybakowski F,
|
||
Rokicki D</span><br />
|
||
<span class="medgenPMjournal">Neuropsychobiology</span>
|
||
2021;80(3):271-275.
|
||
Epub 2020 Jul 20
|
||
doi: 10.1159/000508679.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32688360" target="_blank">32688360</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26819360">Fatal hyperammonaemia due to late-onset ornithine transcarbamylase deficiency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bijvoet GP,
|
||
van der Sijs-Bos CJ,
|
||
Wielders JP,
|
||
Groot OA</span><br />
|
||
<span class="medgenPMjournal">Neth J Med</span>
|
||
2016 Jan;74(1):36-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26819360" target="_blank">26819360</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12514690">Late-onset presentation of ornithine transcarbamylase deficiency in a young woman with hyperammonemic coma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gaspari R,
|
||
Arcangeli A,
|
||
Mensi S,
|
||
Wismayer DS,
|
||
Tartaglione T,
|
||
Antuzzi D,
|
||
Conti G,
|
||
Proietti R</span><br />
|
||
<span class="medgenPMjournal">Ann Emerg Med</span>
|
||
2003 Jan;41(1):104-9.
|
||
doi: 10.1067/mem.2003.6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12514690" target="_blank">12514690</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3945292">Natural history of symptomatic partial ornithine transcarbamylase deficiency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rowe PC,
|
||
Newman SL,
|
||
Brusilow SW</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
1986 Feb 27;314(9):541-7.
|
||
doi: 10.1056/NEJM198602273140903.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3945292" target="_blank">3945292</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Protein%20avoidance%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/17636737">WITHDRAWN: Cow's milk protein avoidance and development of childhood wheeze in children with a family history of atopy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ram FS,
|
||
Ducharme FM,
|
||
Scarlett J</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2007 Jul 18;2007(2):CD003795.
|
||
doi: 10.1002/14651858.CD003795.pub2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17636737" target="_blank">17636737</a><a href="/pmc/articles/PMC10680424" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12514690">Late-onset presentation of ornithine transcarbamylase deficiency in a young woman with hyperammonemic coma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gaspari R,
|
||
Arcangeli A,
|
||
Mensi S,
|
||
Wismayer DS,
|
||
Tartaglione T,
|
||
Antuzzi D,
|
||
Conti G,
|
||
Proietti R</span><br />
|
||
<span class="medgenPMjournal">Ann Emerg Med</span>
|
||
2003 Jan;41(1):104-9.
|
||
doi: 10.1067/mem.2003.6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12514690" target="_blank">12514690</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12137717">Cow's milk protein avoidance and development of childhood wheeze in children with a family history of atopy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ram FS,
|
||
Ducharme FM,
|
||
Scarlett J</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2002;(3):CD003795.
|
||
doi: 10.1002/14651858.CD003795.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12137717" target="_blank">12137717</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7999460">Nonhormonal alternatives for the management of early menopause in younger women with breast cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bachmann GA</span><br />
|
||
<span class="medgenPMjournal">J Natl Cancer Inst Monogr</span>
|
||
1994;(16):161-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7999460" target="_blank">7999460</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Protein%20avoidance%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/26819360">Fatal hyperammonaemia due to late-onset ornithine transcarbamylase deficiency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bijvoet GP,
|
||
van der Sijs-Bos CJ,
|
||
Wielders JP,
|
||
Groot OA</span><br />
|
||
<span class="medgenPMjournal">Neth J Med</span>
|
||
2016 Jan;74(1):36-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26819360" target="_blank">26819360</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12514690">Late-onset presentation of ornithine transcarbamylase deficiency in a young woman with hyperammonemic coma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gaspari R,
|
||
Arcangeli A,
|
||
Mensi S,
|
||
Wismayer DS,
|
||
Tartaglione T,
|
||
Antuzzi D,
|
||
Conti G,
|
||
Proietti R</span><br />
|
||
<span class="medgenPMjournal">Ann Emerg Med</span>
|
||
2003 Jan;41(1):104-9.
|
||
doi: 10.1067/mem.2003.6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12514690" target="_blank">12514690</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Protein%20avoidance%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/3945292">Natural history of symptomatic partial ornithine transcarbamylase deficiency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rowe PC,
|
||
Newman SL,
|
||
Brusilow SW</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
1986 Feb 27;314(9):541-7.
|
||
doi: 10.1056/NEJM198602273140903.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3945292" target="_blank">3945292</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Protein%20avoidance%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div></div>
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<div class="nl"><a target="_blank" href="/pubmed/17636737">WITHDRAWN: Cow's milk protein avoidance and development of childhood wheeze in children with a family history of atopy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ram FS,
|
||
Ducharme FM,
|
||
Scarlett J</span><br />
|
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<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2007 Jul 18;2007(2):CD003795.
|
||
doi: 10.1002/14651858.CD003795.pub2.
|
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<span class="bold">PMID: </span><a href="/pubmed/17636737" target="_blank">17636737</a><a href="/pmc/articles/PMC10680424" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/12137717">Cow's milk protein avoidance and development of childhood wheeze in children with a family history of atopy.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Ram FS,
|
||
Ducharme FM,
|
||
Scarlett J</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2002;(3):CD003795.
|
||
doi: 10.1002/14651858.CD003795.
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<span class="bold">PMID: </span><a href="/pubmed/12137717" target="_blank">12137717</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Protein%20avoidance%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2)</a></div></div>
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