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<!--
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UID=322966
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ConceptID=C1836653
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Ascending aortic dissection</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>322966</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1836653</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome; Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Aorta Dissection, Ascending; Aortic Dissection, Ascending; Ascending Aorta Dissection; Ascending Aorta Dissections; Ascending Aortic Dissection; Ascending Aortic Dissections; Dissection, Ascending Aorta; Dissection, Ascending Aortic</td></tr>
|
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<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0004933">HP:0004933</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">A separation of the layers within the wall of the ascending aorta. Tears in the intimal layer result in the propagation of dissection (proximally or distally) secondary to blood entering the intima-media space. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Ascending aortic dissection</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/892473" ref="tree=MeSH" title="MedGen record for Abnormal cardiovascular system morphology">Abnormal cardiovascular system morphology</a></span><ul><li><span class="TLline"><a href="/medgen/927608" ref="tree=MeSH" title="MedGen record for Abnormal vascular morphology">Abnormal vascular morphology</a></span><ul><li><span class="TLline"><a href="/medgen/1778737" ref="tree=MeSH" title="MedGen record for Abnormal blood vessel morphology">Abnormal blood vessel morphology</a></span><ul><li><span class="TLline"><a href="/medgen/1375454" ref="tree=MeSH" title="MedGen record for Abnormal morphology of the great vessels">Abnormal morphology of the great vessels</a></span><ul><li><span class="TLline"><a href="/medgen/871269" ref="tree=MeSH" title="MedGen record for Abnormal aortic morphology">Abnormal aortic morphology</a></span><ul><li><span class="TLline"><a href="/medgen/1645394" ref="tree=MeSH" title="MedGen record for Abnormal ascending aorta morphology">Abnormal ascending aorta morphology</a></span><ul><li><span class="matched_ds">Ascending aortic dissection</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
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||
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||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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||
<div class="divPopper rprt" id="rdis_82790"><div><strong>Ehlers-Danlos syndrome, type 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>82790</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0268338</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Vascular Ehlers-Danlos syndrome (vEDS) is characterized by arterial, intestinal, and/or uterine fragility; thin, translucent skin; easy bruising; characteristic facial appearance (thin vermilion of the lips, micrognathia, narrow nose, prominent eyes); and an aged appearance to the extremities, particularly the hands. Vascular dissection or rupture, gastrointestinal perforation, or organ rupture are the presenting signs in most adults with vEDS. Arterial rupture may be preceded by aneurysm, arteriovenous fistulae, or dissection but also may occur spontaneously. The majority (60%) of individuals with vEDS who are diagnosed before age 18 years are identified because of a positive family history. Neonates may present with clubfoot, hip dislocation, limb deficiency, and/or amniotic bands. Approximately half of children tested for vEDS in the absence of a positive family history present with a major complication at an average age of 11 years. Four minor diagnostic features – distal joint hypermobility, easy bruising, thin skin, and clubfeet – are most often present in those children ascertained without a major complication.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/82790">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_338704"><div><strong>Aortic aneurysm, familial thoracic 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>338704</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1851504</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Any familial thoracic aortic aneurysm and aortic dissection in which the cause of the disease is a mutation in the MYH11 gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/338704">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_346932"><div><strong>MASS syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>346932</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1858556</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A genetic disorder of connective tissue caused by mutations in the FBN1 gene. Connective tissue is the material between the cells of the body that gives tissues form and strength. Symptoms include mitral valve prolapse, nearsightedness, borderline and non-progressive aortic enlargement, and skin and skeletal findings that overlap with those seen in Marfan syndrome. Treatment is based on the individuals symptoms.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/346932">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_358388"><div><strong>Weill-Marchesani syndrome 2, dominant</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>358388</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1869115</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Weill-Marchesani syndrome (WMS) is a connective tissue disorder characterized by abnormalities of the lens of the eye, short stature, brachydactyly, joint stiffness, and cardiovascular defects. The ocular problems, typically recognized in childhood, include microspherophakia (small spherical lens), myopia secondary to the abnormal shape of the lens, ectopia lentis (abnormal position of the lens), and glaucoma, which can lead to blindness. Height of adult males is 142-169 cm; height of adult females is 130-157 cm. Autosomal recessive WMS cannot be distinguished from autosomal dominant WMS by clinical findings alone.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/358388">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_435866"><div><strong>Aortic aneurysm, familial thoracic 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>435866</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2673186</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Any familial thoracic aortic aneurysm and aortic dissection in which the cause of the disease is a mutation in the ACTA2 gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/435866">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_382398"><div><strong>Loeys-Dietz syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>382398</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C2674574</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Loeys-Dietz syndrome (LDS) is characterized by vascular findings (cerebral, thoracic, and abdominal arterial aneurysms and/or dissections), skeletal manifestations (pectus excavatum or pectus carinatum, scoliosis, joint laxity, arachnodactyly, talipes equinovarus, and cervical spine malformation and/or instability), craniofacial features (hypertelorism, strabismus, bifid uvula / cleft palate, and craniosynostosis that can involve any sutures), and cutaneous findings (velvety and translucent skin, easy bruising, and dystrophic scars). Individuals with LDS are predisposed to widespread and aggressive arterial aneurysms and pregnancy-related complications including uterine rupture and death. Individuals with LDS can show a strong predisposition for allergic/inflammatory disease including asthma, eczema, and reactions to food or environmental allergens. There is also an increased incidence of gastrointestinal inflammation including eosinophilic esophagitis and gastritis or inflammatory bowel disease. Wide variation in the distribution and severity of clinical features can be seen in individuals with LDS, even among affected individuals within a family who have the same pathogenic variant.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/382398">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_462427"><div><strong>Aortic aneurysm, familial thoracic 7</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462427</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3151077</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462427">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_462437"><div><strong>Aneurysm-osteoarthritis syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462437</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3151087</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Loeys-Dietz syndrome (LDS) is characterized by vascular findings (cerebral, thoracic, and abdominal arterial aneurysms and/or dissections), skeletal manifestations (pectus excavatum or pectus carinatum, scoliosis, joint laxity, arachnodactyly, talipes equinovarus, and cervical spine malformation and/or instability), craniofacial features (hypertelorism, strabismus, bifid uvula / cleft palate, and craniosynostosis that can involve any sutures), and cutaneous findings (velvety and translucent skin, easy bruising, and dystrophic scars). Individuals with LDS are predisposed to widespread and aggressive arterial aneurysms and pregnancy-related complications including uterine rupture and death. Individuals with LDS can show a strong predisposition for allergic/inflammatory disease including asthma, eczema, and reactions to food or environmental allergens. There is also an increased incidence of gastrointestinal inflammation including eosinophilic esophagitis and gastritis or inflammatory bowel disease. Wide variation in the distribution and severity of clinical features can be seen in individuals with LDS, even among affected individuals within a family who have the same pathogenic variant.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462437">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_762200"><div><strong>Aortic valve disease 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>762200</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3542024</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Any aortic valve disease in which the cause of the disease is a mutation in the SMAD6 gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/762200">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_815843"><div><strong>Aortic aneurysm, familial thoracic 8</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>815843</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3809513</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Any familial thoracic aortic aneurysm and aortic dissection in which the cause of the disease is a mutation in the PRKG1 gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/815843">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_816342"><div><strong>Rienhoff syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>816342</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3810012</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Loeys-Dietz syndrome (LDS) is characterized by vascular findings (cerebral, thoracic, and abdominal arterial aneurysms and/or dissections), skeletal manifestations (pectus excavatum or pectus carinatum, scoliosis, joint laxity, arachnodactyly, talipes equinovarus, and cervical spine malformation and/or instability), craniofacial features (hypertelorism, strabismus, bifid uvula / cleft palate, and craniosynostosis that can involve any sutures), and cutaneous findings (velvety and translucent skin, easy bruising, and dystrophic scars). Individuals with LDS are predisposed to widespread and aggressive arterial aneurysms and pregnancy-related complications including uterine rupture and death. Individuals with LDS can show a strong predisposition for allergic/inflammatory disease including asthma, eczema, and reactions to food or environmental allergens. There is also an increased incidence of gastrointestinal inflammation including eosinophilic esophagitis and gastritis or inflammatory bowel disease. Wide variation in the distribution and severity of clinical features can be seen in individuals with LDS, even among affected individuals within a family who have the same pathogenic variant.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/816342">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_863805"><div><strong>Aortic aneurysm, familial thoracic 9</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>863805</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4015368</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Any familial thoracic aortic aneurysm and aortic dissection in which the cause of the disease is a mutation in the MFAP5 gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/863805">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_924785"><div><strong>Aortic aneurysm, familial thoracic 10</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>924785</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4284414</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Any familial thoracic aortic aneurysm and aortic dissection in which the cause of the disease is a mutation in the LOX gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/924785">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1377970"><div><strong>Aortic aneurysm, familial thoracic 11, susceptibility to</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1377970</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4479235</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1377970">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1646567"><div><strong>Loeys-Dietz syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1646567</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4551955</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Loeys-Dietz syndrome (LDS) is characterized by vascular findings (cerebral, thoracic, and abdominal arterial aneurysms and/or dissections), skeletal manifestations (pectus excavatum or pectus carinatum, scoliosis, joint laxity, arachnodactyly, talipes equinovarus, and cervical spine malformation and/or instability), craniofacial features (hypertelorism, strabismus, bifid uvula / cleft palate, and craniosynostosis that can involve any sutures), and cutaneous findings (velvety and translucent skin, easy bruising, and dystrophic scars). Individuals with LDS are predisposed to widespread and aggressive arterial aneurysms and pregnancy-related complications including uterine rupture and death. Individuals with LDS can show a strong predisposition for allergic/inflammatory disease including asthma, eczema, and reactions to food or environmental allergens. There is also an increased incidence of gastrointestinal inflammation including eosinophilic esophagitis and gastritis or inflammatory bowel disease. Wide variation in the distribution and severity of clinical features can be seen in individuals with LDS, even among affected individuals within a family who have the same pathogenic variant.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1646567">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1681142"><div><strong>Aortic valve disease 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1681142</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5193127</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Aortic valve disease-3 (AOVD3) is characterized by aortic stenosis and/or bicuspid aortic valve (BAV), associated in some patients with aneurysm of the aortic root and/or ascending aorta. Atrial septal defect (ASD) has also been observed in some individuals (Gould et al., 2019). For a general phenotypic description and a discussion of genetic heterogeneity of aortic valve disease, see AOVD1 (109730).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1681142">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1802657"><div><strong>Aortic aneurysm, familial thoracic 12</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1802657</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5676959</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial thoracic aortic aneurysm-12 (AAT12) is characterized by dilation of the arterial wall associated with a progressive loss of its ability to withstand the wall tension generated by high intraluminal pressure, which can lead to intramural or complete acute vessel wall rupture. Some patients have dolichostenomelia (summary by Elbitar et al., 2021). For a general phenotypic description and a discussion of genetic heterogeneity of thoracic aortic aneurysm, see AAT1 (607086).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1802657">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1824007"><div><strong>Neuronopathy, distal hereditary motor, autosomal dominant 10</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1824007</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5774234</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autosomal dominant distal hereditary motor neuronopathy-10 (HMND10) is a neurologic disorder of the peripheral nerves characterized clinically by length-dependent motor neuropathy primarily affecting the lower limbs. Affected individuals have onset of distal muscle weakness and atrophy in early childhood that results in walking difficulties and gait abnormalities. Some have pyramidal signs, including hyperreflexia, suggesting the involvement of upper motor neurons. Electrophysiologic studies are consistent with a neurogenic process. More variable features may include mild intellectual disability, minor gyration defects on brain imaging, foot deformities, and connective tissue defects (1 family) (Capuano et al., 2016; Iacomino et al., 2020). For a discussion of genetic heterogeneity of autosomal dominant distal HMN, see HMND1 (182960).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1824007">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462437" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Aneurysm-osteoarthritis syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_924785" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Aortic aneurysm, familial thoracic 10</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1377970" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Aortic aneurysm, familial thoracic 11, susceptibility to</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1802657" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Aortic aneurysm, familial thoracic 12</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_338704" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Aortic aneurysm, familial thoracic 4</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (18)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_435866" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Aortic aneurysm, familial thoracic 6</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462427" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Aortic aneurysm, familial thoracic 7</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_815843" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Aortic aneurysm, familial thoracic 8</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_863805" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Aortic aneurysm, familial thoracic 9</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_762200" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Aortic valve disease 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1681142" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Aortic valve disease 3</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_82790" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ehlers-Danlos syndrome, type 4</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1646567" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Loeys-Dietz syndrome 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_382398" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Loeys-Dietz syndrome 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_346932" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">MASS syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1824007" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neuronopathy, distal hereditary motor, autosomal dominant 10</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_816342" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Rienhoff syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_358388" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Weill-Marchesani syndrome 2, dominant</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39382217">Management of iatrogenic ascending aortic dissection after percutaneous intervention of chronic total occlusion.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Safdar A,
|
||
Young L,
|
||
Khatri J</span><br />
|
||
<span class="medgenPMjournal">Catheter Cardiovasc Interv</span>
|
||
2024 Dec;104(7):1442-1446.
|
||
Epub 2024 Oct 9
|
||
doi: 10.1002/ccd.31262.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39382217" target="_blank">39382217</a><a href="/pmc/articles/PMC11667411" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34500032">Toward endovascular treatment of type A aortic dissection with smaller landing zones and more patient eligibility.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wisneski AD,
|
||
Kumar V,
|
||
Vartanian SM,
|
||
Oskowitz AZ</span><br />
|
||
<span class="medgenPMjournal">J Vasc Surg</span>
|
||
2022 Jan;75(1):47-55.e1.
|
||
Epub 2021 Sep 6
|
||
doi: 10.1016/j.jvs.2021.08.054.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34500032" target="_blank">34500032</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18083364">Expert consensus document on the treatment of descending thoracic aortic disease using endovascular stent-grafts.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Svensson LG,
|
||
Kouchoukos NT,
|
||
Miller DC,
|
||
Bavaria JE,
|
||
Coselli JS,
|
||
Curi MA,
|
||
Eggebrecht H,
|
||
Elefteriades JA,
|
||
Erbel R,
|
||
Gleason TG,
|
||
Lytle BW,
|
||
Mitchell RS,
|
||
Nienaber CA,
|
||
Roselli EE,
|
||
Safi HJ,
|
||
Shemin RJ,
|
||
Sicard GA,
|
||
Sundt TM 3rd,
|
||
Szeto WY,
|
||
Wheatley GH 3rd;
|
||
Society of Thoracic Surgeons Endovascular Surgery Task Force</span><br />
|
||
<span class="medgenPMjournal">Ann Thorac Surg</span>
|
||
2008 Jan;85(1 Suppl):S1-41.
|
||
doi: 10.1016/j.athoracsur.2007.10.099.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18083364" target="_blank">18083364</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22ascending%20aortic%20dissection%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (10)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35943618">Aortic Dissection is Determined by Specific Shape and Hemodynamic Interactions.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Williams JG,
|
||
Marlevi D,
|
||
Bruse JL,
|
||
Nezami FR,
|
||
Moradi H,
|
||
Fortunato RN,
|
||
Maiti S,
|
||
Billaud M,
|
||
Edelman ER,
|
||
Gleason TG</span><br />
|
||
<span class="medgenPMjournal">Ann Biomed Eng</span>
|
||
2022 Dec;50(12):1771-1786.
|
||
Epub 2022 Aug 9
|
||
doi: 10.1007/s10439-022-02979-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35943618" target="_blank">35943618</a><a href="/pmc/articles/PMC11262626" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31595660">Systematic review of endovascular repair of ascending aortic dissection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang L,
|
||
Li Z,
|
||
Li S,
|
||
Zhao Z,
|
||
Bao J,
|
||
Zhou J,
|
||
Jing Z</span><br />
|
||
<span class="medgenPMjournal">Catheter Cardiovasc Interv</span>
|
||
2019 Dec 1;94(7):1018-1025.
|
||
Epub 2019 Oct 8
|
||
doi: 10.1002/ccd.28511.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31595660" target="_blank">31595660</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30391968">Neovascularization with chronic inflammation characterizes ascending aortic dissection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Niinimäk E,
|
||
Pynnönen V,
|
||
Kholova I,
|
||
Paavonen T,
|
||
Mennander A</span><br />
|
||
<span class="medgenPMjournal">Anatol J Cardiol</span>
|
||
2018 Nov;20(5):289-295.
|
||
doi: 10.14744/AnatolJCardiol.2018.42223.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30391968" target="_blank">30391968</a><a href="/pmc/articles/PMC6280283" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30211773">The Perioperative Management of Ascending Aortic Dissection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gregory SH,
|
||
Yalamuri SM,
|
||
Bishawi M,
|
||
Swaminathan M</span><br />
|
||
<span class="medgenPMjournal">Anesth Analg</span>
|
||
2018 Dec;127(6):1302-1313.
|
||
doi: 10.1213/ANE.0000000000003747.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30211773" target="_blank">30211773</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25081248">Nonoperative management of an iatrogenic ascending aortic dissection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ren C,
|
||
Xu S,
|
||
Lai Y,
|
||
Sun L</span><br />
|
||
<span class="medgenPMjournal">J Card Surg</span>
|
||
2014 Sep;29(5):667-9.
|
||
Epub 2014 Aug 1
|
||
doi: 10.1111/jocs.12416.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25081248" target="_blank">25081248</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ascending%20aortic%20dissection%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (134)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36240867">The Jigsaw Puzzle of Arch Management in Acute Ascending Aortic Dissection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">François K</span><br />
|
||
<span class="medgenPMjournal">Ann Thorac Surg</span>
|
||
2023 Apr;115(4):903-904.
|
||
Epub 2022 Oct 12
|
||
doi: 10.1016/j.athoracsur.2022.09.044.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36240867" target="_blank">36240867</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35038746">Could focused bedside transthoracic echocardiography improve the diagnosis of ascending aortic dissection?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ioannou A</span><br />
|
||
<span class="medgenPMjournal">QJM</span>
|
||
2022 Dec 12;115(12):871-872.
|
||
doi: 10.1093/qjmed/hcac003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35038746" target="_blank">35038746</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29572950">Failure of CT angiogram to detect an ascending aortic dissection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Masri A,
|
||
Bianco V,
|
||
Kilic A,
|
||
Gleason TG,
|
||
Sultan I</span><br />
|
||
<span class="medgenPMjournal">J Card Surg</span>
|
||
2018 Apr;33(4):194-195.
|
||
Epub 2018 Mar 24
|
||
doi: 10.1111/jocs.13562.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29572950" target="_blank">29572950</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22795434">Acute ascending aortic dissection during transaortic balloon-expandable aortic valve implantation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">D'Onofrio A,
|
||
Tessari C,
|
||
Bianco R,
|
||
Isabella G,
|
||
Di Gregorio G,
|
||
Gerosa G</span><br />
|
||
<span class="medgenPMjournal">J Thorac Cardiovasc Surg</span>
|
||
2012 Sep;144(3):e97-9.
|
||
Epub 2012 Jul 11
|
||
doi: 10.1016/j.jtcvs.2012.06.032.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22795434" target="_blank">22795434</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/4050665">Ascending aortic dissection: detection by MRI.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hill JA,
|
||
Lambert CR,
|
||
Akins EW,
|
||
Carmichael MJ</span><br />
|
||
<span class="medgenPMjournal">Am Heart J</span>
|
||
1985 Oct;110(4):894-6.
|
||
doi: 10.1016/0002-8703(85)90480-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/4050665" target="_blank">4050665</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ascending%20aortic%20dissection%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (144)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37652784">Iatrogenic Acute Ascending Aortic Dissection During Combined Heart/Liver Transplant for Amyloidosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wadiwala IJ,
|
||
Garg P,
|
||
Pham V,
|
||
Taner CB,
|
||
Farres H,
|
||
Krishna M,
|
||
Pham SM</span><br />
|
||
<span class="medgenPMjournal">Transplant Proc</span>
|
||
2023 Oct;55(8):1978-1980.
|
||
Epub 2023 Aug 30
|
||
doi: 10.1016/j.transproceed.2023.07.018.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37652784" target="_blank">37652784</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36669983">Noncompliant Balloon Shaft Rupture Resulting in Ascending Aortic Dissection: Complication During Percutaneous Coronary Intervention.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kabir R,
|
||
Weissman G,
|
||
Rogers T,
|
||
Hashim H,
|
||
Satler LF,
|
||
Waksman R,
|
||
Ben-Dor I</span><br />
|
||
<span class="medgenPMjournal">JACC Cardiovasc Interv</span>
|
||
2023 Feb 27;16(4):490-491.
|
||
Epub 2023 Jan 18
|
||
doi: 10.1016/j.jcin.2022.10.031.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36669983" target="_blank">36669983</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36480998">Transcatheter Aortic Valve Replacement in a Patient With Chronic Type A Aortic Dissection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">McInerney A,
|
||
Tirado-Conte G,
|
||
Jimenez-Quevedo P,
|
||
Vilacosta I,
|
||
Nombela-Franco L</span><br />
|
||
<span class="medgenPMjournal">JACC Cardiovasc Interv</span>
|
||
2022 Dec 12;15(23):e239-e240.
|
||
Epub 2022 Nov 16
|
||
doi: 10.1016/j.jcin.2022.08.029.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36480998" target="_blank">36480998</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31595660">Systematic review of endovascular repair of ascending aortic dissection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang L,
|
||
Li Z,
|
||
Li S,
|
||
Zhao Z,
|
||
Bao J,
|
||
Zhou J,
|
||
Jing Z</span><br />
|
||
<span class="medgenPMjournal">Catheter Cardiovasc Interv</span>
|
||
2019 Dec 1;94(7):1018-1025.
|
||
Epub 2019 Oct 8
|
||
doi: 10.1002/ccd.28511.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31595660" target="_blank">31595660</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22795434">Acute ascending aortic dissection during transaortic balloon-expandable aortic valve implantation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">D'Onofrio A,
|
||
Tessari C,
|
||
Bianco R,
|
||
Isabella G,
|
||
Di Gregorio G,
|
||
Gerosa G</span><br />
|
||
<span class="medgenPMjournal">J Thorac Cardiovasc Surg</span>
|
||
2012 Sep;144(3):e97-9.
|
||
Epub 2012 Jul 11
|
||
doi: 10.1016/j.jtcvs.2012.06.032.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22795434" target="_blank">22795434</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ascending%20aortic%20dissection%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (69)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38471650">Outcomes for patients undergoing transcatheter aortic valve replacement with ascending aorta dilation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Feng D,
|
||
Zhao J,
|
||
Niu G,
|
||
Zhang Y,
|
||
Wang C,
|
||
Chen Y,
|
||
Zhou Z,
|
||
Zhang H,
|
||
Zhao Z,
|
||
Ye Y,
|
||
Li Z,
|
||
Xu H,
|
||
Wang M,
|
||
Wu Y</span><br />
|
||
<span class="medgenPMjournal">Int J Cardiol</span>
|
||
2024 Jun 15;405:131948.
|
||
Epub 2024 Mar 11
|
||
doi: 10.1016/j.ijcard.2024.131948.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38471650" target="_blank">38471650</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33528062">Analysis of ascending aortic diameter and long-term prognosis in patients with ascending aortic dissection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wu Y,
|
||
Gong M,
|
||
Fan R,
|
||
Gu T,
|
||
Qian X,
|
||
Zhang H</span><br />
|
||
<span class="medgenPMjournal">Echocardiography</span>
|
||
2021 Apr;38(4):531-539.
|
||
Epub 2021 Feb 2
|
||
doi: 10.1111/echo.14980.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33528062" target="_blank">33528062</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25081248">Nonoperative management of an iatrogenic ascending aortic dissection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ren C,
|
||
Xu S,
|
||
Lai Y,
|
||
Sun L</span><br />
|
||
<span class="medgenPMjournal">J Card Surg</span>
|
||
2014 Sep;29(5):667-9.
|
||
Epub 2014 Aug 1
|
||
doi: 10.1111/jocs.12416.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25081248" target="_blank">25081248</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22077975">Aortic medial elastic fiber loss in acute ascending aortic dissection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Roberts WC,
|
||
Vowels TJ,
|
||
Kitchens BL,
|
||
Ko JM,
|
||
Filardo G,
|
||
Henry AC,
|
||
Hamman BL,
|
||
Matter GJ,
|
||
Hebeler RF Jr</span><br />
|
||
<span class="medgenPMjournal">Am J Cardiol</span>
|
||
2011 Dec 1;108(11):1639-44.
|
||
doi: 10.1016/j.amjcard.2011.09.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22077975" target="_blank">22077975</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2979929">Treatment of ascending aortic dissection in the Marfan syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kouchoukos NT,
|
||
Marshall WG Jr</span><br />
|
||
<span class="medgenPMjournal">J Card Surg</span>
|
||
1986 Dec;1(4):333-46.
|
||
doi: 10.1111/j.1540-8191.1986.tb00721.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2979929" target="_blank">2979929</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ascending%20aortic%20dissection%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (87)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34500026">Outcomes and role of peripheral revascularization in type A aortic dissection presenting with acute lower extremity ischemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Beck CJ,
|
||
Germano E,
|
||
Artis AS,
|
||
Kirksey L,
|
||
Smolock CJ,
|
||
Lyden SP,
|
||
Bakaeen FG,
|
||
Menon V,
|
||
Roselli EE,
|
||
Farivar BS</span><br />
|
||
<span class="medgenPMjournal">J Vasc Surg</span>
|
||
2022 Feb;75(2):495-503.e5.
|
||
Epub 2021 Sep 6
|
||
doi: 10.1016/j.jvs.2021.08.050.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34500026" target="_blank">34500026</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34304394">Hybrid repair versus conventional open repair for aortic arch dissection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kavanagh EP,
|
||
Sultan S,
|
||
Jordan F,
|
||
Elhelali A,
|
||
Devane D,
|
||
Veerasingam D,
|
||
Hynes N</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2021 Jul 25;7(7):CD012920.
|
||
doi: 10.1002/14651858.CD012920.pub2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34304394" target="_blank">34304394</a><a href="/pmc/articles/PMC8407229" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32927033">Prevention of Retrograde Ascending Aortic Dissection by Cardiac Pacing During Hybrid Surgery for Zone 0 Aortic Arch Repair.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chassin-Trubert L,
|
||
Ozdemir BA,
|
||
Roussel A,
|
||
Dessertenne G,
|
||
Castier Y,
|
||
Ludovic C,
|
||
Alric P</span><br />
|
||
<span class="medgenPMjournal">Ann Vasc Surg</span>
|
||
2021 Feb;71:48-55.
|
||
Epub 2020 Sep 11
|
||
doi: 10.1016/j.avsg.2020.08.136.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32927033" target="_blank">32927033</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25222152">Redo surgery in ascending aorta and aortic arch.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chiesa R,
|
||
Bertoglio L,
|
||
Kahlberg A,
|
||
Rinaldi E,
|
||
Tshomba Y,
|
||
Melissano G</span><br />
|
||
<span class="medgenPMjournal">J Cardiovasc Surg (Torino)</span>
|
||
2014 Dec;55(6):803-12.
|
||
Epub 2014 Sep 15
|
||
<span class="bold">PMID: </span><a href="/pubmed/25222152" target="_blank">25222152</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22265798">Retrograde ascending aortic dissection as an early complication of thoracic endovascular aortic repair.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Williams JB,
|
||
Andersen ND,
|
||
Bhattacharya SD,
|
||
Scheer E,
|
||
Piccini JP,
|
||
McCann RL,
|
||
Hughes GC</span><br />
|
||
<span class="medgenPMjournal">J Vasc Surg</span>
|
||
2012 May;55(5):1255-62.
|
||
Epub 2012 Jan 23
|
||
doi: 10.1016/j.jvs.2011.11.063.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22265798" target="_blank">22265798</a><a href="/pmc/articles/PMC3699184" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ascending%20aortic%20dissection%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (37)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/38825544">Central versus peripheral cannulation for acute type A aortic dissection: A meta-analysis of over 14,000 patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Samadzadeh Tabrizi N,
|
||
Sá MP,
|
||
Jacquemyn X,
|
||
Yousef S,
|
||
Brown JA,
|
||
Serna-Gallegos D,
|
||
Sultan I</span><br />
|
||
<span class="medgenPMjournal">Am J Surg</span>
|
||
2024 Nov;237:115780.
|
||
Epub 2024 May 29
|
||
doi: 10.1016/j.amjsurg.2024.115780.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38825544" target="_blank">38825544</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34304394">Hybrid repair versus conventional open repair for aortic arch dissection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kavanagh EP,
|
||
Sultan S,
|
||
Jordan F,
|
||
Elhelali A,
|
||
Devane D,
|
||
Veerasingam D,
|
||
Hynes N</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2021 Jul 25;7(7):CD012920.
|
||
doi: 10.1002/14651858.CD012920.pub2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34304394" target="_blank">34304394</a><a href="/pmc/articles/PMC8407229" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31595660">Systematic review of endovascular repair of ascending aortic dissection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang L,
|
||
Li Z,
|
||
Li S,
|
||
Zhao Z,
|
||
Bao J,
|
||
Zhou J,
|
||
Jing Z</span><br />
|
||
<span class="medgenPMjournal">Catheter Cardiovasc Interv</span>
|
||
2019 Dec 1;94(7):1018-1025.
|
||
Epub 2019 Oct 8
|
||
doi: 10.1002/ccd.28511.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31595660" target="_blank">31595660</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ascending%20aortic%20dissection%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3)</a></div></div>
|
||
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|
||
</div></div></div></div></div></div></div>
|
||
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|
||
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|
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|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
|
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|
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|
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Ascending%20aortic%20dissection" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22ascending%20aortic%20dissection%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Ascending%20aortic%20dissection%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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