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<meta name="keywords" content="C1832426, familial wilms tumor 1, familial wilms tumour 1, fwt1, neoplastic process, wilms tumor 4, wilms tumor type 4, wilms tumor, type 4, wilms tumour type 4, wt4, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="With proper treatment, children with Wilms tumor have a 90 percent survival rate. However, the risk that the cancer will come back (recur) is between 15 and 50 percent, depending on traits of the original tumor. Tumors usually recur in the first 2 years following treatment and develop in the kidneys or other tissues, such as the lungs. Individuals who have had Wilms tumor may experience related health problems or late effects of their treatment in adulthood, such as decreased kidney function, heart disease, and development of additional cancers.\n\nWilms tumor can develop in one or both kidneys. About 5 to 10 percent of affected individuals develop multiple tumors in one or both kidneys. Wilms tumor may spread from the kidneys to other parts of the body (metastasize). In rare cases, Wilms tumor does not involve the kidneys and occurs instead in the genital tract, bladder, abdomen, chest, or lower back. It is unclear how Wilms tumor develops in these tissues.\n\nWilms tumor is often first noticed because of abdominal swelling or a mass in the kidney that can be felt upon physical examination. Some affected children have abdominal pain, fever, a low number of red blood cells (anemia), blood in the urine (hematuria), or high blood pressure (hypertension). Additional signs of Wilms tumor can include loss of appetite, weight loss, nausea, vomiting, and tiredness (lethargy).\n\nWilms tumor is a form of kidney cancer that primarily develops in children. Nearly all cases of Wilms tumor are diagnosed before the age of 10, with two-thirds being found before age 5." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
|
||
UID=318623
|
||
ConceptID=C1832426
|
||
-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Wilms tumor 4<span class="h1sub">(WT4)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>318623</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1832426</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>FAMILIAL WILMS TUMOR 1; WT4</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0011056" target="_blank">MONDO:0011056</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/601363" target="_blank">601363</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_100">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">With proper treatment, children with Wilms tumor have a 90 percent survival rate. However, the risk that the cancer will come back (recur) is between 15 and 50 percent, depending on traits of the original tumor. Tumors usually recur in the first 2 years following treatment and develop in the kidneys or other tissues, such as the lungs. Individuals who have had Wilms tumor may experience related health problems or late effects of their treatment in adulthood, such as decreased kidney function, heart disease, and development of additional cancers.<br /><br />Wilms tumor can develop in one or both kidneys. About 5 to 10 percent of affected individuals develop multiple tumors in one or both kidneys. Wilms tumor may spread from the kidneys to other parts of the body (metastasize). In rare cases, Wilms tumor does not involve the kidneys and occurs instead in the genital tract, bladder, abdomen, chest, or lower back. It is unclear how Wilms tumor develops in these tissues.<br /><br />Wilms tumor is often first noticed because of abdominal swelling or a mass in the kidney that can be felt upon physical examination. Some affected children have abdominal pain, fever, a low number of red blood cells (anemia), blood in the urine (hematuria), or high blood pressure (hypertension). Additional signs of Wilms tumor can include loss of appetite, weight loss, nausea, vomiting, and tiredness (lethargy).<br /><br />Wilms tumor is a form of kidney cancer that primarily develops in children. Nearly all cases of Wilms tumor are diagnosed before the age of 10, with two-thirds being found before age 5. [from <a title="MedlinePlus Genetics" href="https://medlineplus.gov/genetics/" class="defSource" target="_blank">MedlinePlus Genetics</a>]</div>
|
||
</div>
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||
|
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<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_10221"><div><strong>Nephroblastoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>10221</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0027708</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The presence of a nephroblastoma, which is a neoplasm of the kidney that primarily affects children.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/10221">Feature record</a> | <a href="/medgen?term=%22Nephroblastoma%22%5BClinical%20Features%5D%20OR%2010221%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite"><ul><li><span class="TLline">Neoplasm</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_10221" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Nephroblastoma</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0027708[DISCUI]&test_type=Clinical" ref="ncbi_uid=10221">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=10221" target="_blank" href="/omim/194070">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=10221" ref="ncbi_uid=10221">V</a></span></span><span class="TLline"><a href="/medgen/10221" ref="tree=GTR&ncbi_uid=10221&link_uid=10221" title="View MedGen record for 'Nephroblastoma'">Nephroblastoma</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/989515" ref="tree=GTR&ncbi_uid=989515&link_uid=989515" title="View MedGen record for 'Kidney Wilms tumor'">Kidney Wilms tumor</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0677779[DISCUI]&test_type=Clinical" ref="ncbi_uid=146190">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/146190" ref="tree=GTR&ncbi_uid=146190&link_uid=146190" title="View MedGen record for 'Hereditary Wilms tumor'">Hereditary Wilms tumor</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=CN033288[DISCUI]&test_type=Clinical" ref="ncbi_uid=447509">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/?term=(NBK1294%20OR%20NBK1360%20OR%20NBK556455)%20AND%20gene%5Bbook%5D&showtype=onebook" ref="ncbi_uid=447509">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=447509" ref="ncbi_uid=447509">V</a></span></span><span class="TLline"><a href="/medgen/447509" ref="tree=GTR&ncbi_uid=447509&link_uid=447509" title="View MedGen record for 'Wilms tumor 1'">Wilms tumor 1</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3887743[DISCUI]&test_type=Clinical" ref="ncbi_uid=854562">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=854562" target="_blank" href="/omim/194071">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1294/" ref="ncbi_uid=854562">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=854562" ref="ncbi_uid=854562">V</a></span></span><span class="TLline"><a href="/medgen/854562" ref="tree=GTR&ncbi_uid=854562&link_uid=854562" title="View MedGen record for 'Wilms tumor 2'">Wilms tumor 2</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1860265[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=349770">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=349770" target="_blank" href="/omim/194090">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1294/" ref="ncbi_uid=349770">G</a></span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/349770" ref="tree=GTR&ncbi_uid=349770&link_uid=349770" title="View MedGen record for 'Wilms tumor 3'">Wilms tumor 3</a></span></li><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1832426[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=318623">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=318623" target="_blank" href="/omim/601363">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1294/" ref="ncbi_uid=318623">G</a></span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Wilms tumor 4</span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1832099[DISCUI]&test_type=Clinical" ref="ncbi_uid=316905">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=316905" target="_blank" href="/omim/601583">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=316905" ref="ncbi_uid=316905">V</a></span></span><span class="TLline"><a href="/medgen/316905" ref="tree=GTR&ncbi_uid=316905&link_uid=316905" title="View MedGen record for 'Wilms tumor 5'">Wilms tumor 5</a></span></li></ul></li></ul></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/10294" ref="tree=MeSH" title="MedGen record for Neoplasm">Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/14297" ref="tree=MeSH" title="MedGen record for Malignant neoplastic disease">Malignant neoplastic disease</a></span><ul><li><span class="TLline"><a href="/medgen/232504" ref="tree=MeSH" title="MedGen record for Hereditary cancer">Hereditary cancer</a></span><ul><li><span class="TLline"><a href="/medgen/1650763" ref="tree=MeSH" title="MedGen record for Hereditary Malignant Urinary System Neoplasm">Hereditary Malignant Urinary System Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/146190" ref="tree=MeSH" title="MedGen record for Hereditary Wilms tumor">Hereditary Wilms tumor</a></span><ul><li><span class="matched_ds">Wilms tumor 4</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/31099132">Customized approach for upfront or delayed resection using radiological criteria in unilateral, nonmetastatic pediatric renal tumors: A prospective study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Qureshi SS,
|
||
Kembhavi SA,
|
||
Bhagat M,
|
||
Kapadia T,
|
||
Prasad M,
|
||
Vora T,
|
||
Chinnaswamy G,
|
||
Ramadwar M,
|
||
Laskar S,
|
||
Khanna N,
|
||
Baheti A,
|
||
Shah S,
|
||
Kurkure P,
|
||
Talole S</span><br />
|
||
<span class="medgenPMjournal">Pediatr Blood Cancer</span>
|
||
2019 Aug;66 Suppl 3:e27815.
|
||
Epub 2019 May 16
|
||
doi: 10.1002/pbc.27815.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31099132" target="_blank">31099132</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16020133">Thymic and adenotonsillar enlargement after successful treatment of malignancies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Oguz A,
|
||
Karadeniz C,
|
||
Citak EC,
|
||
Conly NA,
|
||
Ileri F,
|
||
Boyunaga O,
|
||
Okur V,
|
||
Uluoglu O</span><br />
|
||
<span class="medgenPMjournal">Pediatr Hematol Oncol</span>
|
||
2005 Jul-Aug;22(5):423-35.
|
||
doi: 10.1080/08880010590964417.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16020133" target="_blank">16020133</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22wilms%20tumor%204%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (2)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/wilms_tumor.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Wilms Tumor (Nephroblastoma), 2023</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35760918">Beyond Wilms tumor: imaging findings and outcomes of rare renal tumors in children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ayaz E,
|
||
Ozcan HN,
|
||
Oguz B,
|
||
Haliloglu M</span><br />
|
||
<span class="medgenPMjournal">Pediatr Radiol</span>
|
||
2022 Dec;52(13):2557-2567.
|
||
Epub 2022 Jun 28
|
||
doi: 10.1007/s00247-022-05422-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35760918" target="_blank">35760918</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23511492">Spinal cord compression in childhood pediatric malignancies: multicenter egyptian study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tantawy AA,
|
||
Ebeid FS,
|
||
Mahmoud MA,
|
||
Shepl OE</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Hematol Oncol</span>
|
||
2013 Apr;35(3):232-6.
|
||
doi: 10.1097/MPH.0b013e318270b210.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23511492" target="_blank">23511492</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20101509">Leukemia, non-Hodgkin's lymphoma, and Wilms tumor in childhood: the role of birth weight.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rangel M,
|
||
Cypriano M,
|
||
de Martino Lee ML,
|
||
Luisi FA,
|
||
Petrilli AS,
|
||
Strufaldi MW,
|
||
Franco Mdo C</span><br />
|
||
<span class="medgenPMjournal">Eur J Pediatr</span>
|
||
2010 Jul;169(7):875-81.
|
||
Epub 2010 Jan 26
|
||
doi: 10.1007/s00431-010-1139-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20101509" target="_blank">20101509</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wilms%20tumor%204%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35760918">Beyond Wilms tumor: imaging findings and outcomes of rare renal tumors in children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ayaz E,
|
||
Ozcan HN,
|
||
Oguz B,
|
||
Haliloglu M</span><br />
|
||
<span class="medgenPMjournal">Pediatr Radiol</span>
|
||
2022 Dec;52(13):2557-2567.
|
||
Epub 2022 Jun 28
|
||
doi: 10.1007/s00247-022-05422-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35760918" target="_blank">35760918</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32681944">Secondary renal neoplasia following chemotherapy or radiation in pediatric patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gupta S,
|
||
Vanderbilt CM,
|
||
Leibovich BC,
|
||
Herrera-Hernandez L,
|
||
Raghunathan A,
|
||
Sukov WR,
|
||
Voss JS,
|
||
Barr Fritcher EG,
|
||
Reed KA,
|
||
Lohse CM,
|
||
Reuter VE,
|
||
Jimenez RE,
|
||
Thompson RH,
|
||
Cheville JC</span><br />
|
||
<span class="medgenPMjournal">Hum Pathol</span>
|
||
2020 Sep;103:1-13.
|
||
Epub 2020 Jul 15
|
||
doi: 10.1016/j.humpath.2020.07.014.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32681944" target="_blank">32681944</a><a href="/pmc/articles/PMC8935764" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23511492">Spinal cord compression in childhood pediatric malignancies: multicenter egyptian study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tantawy AA,
|
||
Ebeid FS,
|
||
Mahmoud MA,
|
||
Shepl OE</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Hematol Oncol</span>
|
||
2013 Apr;35(3):232-6.
|
||
doi: 10.1097/MPH.0b013e318270b210.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23511492" target="_blank">23511492</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10348288">Anesthesia for pediatric external beam radiation therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fortney JT,
|
||
Halperin EC,
|
||
Hertz CM,
|
||
Schulman SR</span><br />
|
||
<span class="medgenPMjournal">Int J Radiat Oncol Biol Phys</span>
|
||
1999 Jun 1;44(3):587-91.
|
||
doi: 10.1016/s0360-3016(99)00058-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10348288" target="_blank">10348288</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/169727">Diagnostic value of cytologic specimens obtained from children with cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Helson L,
|
||
Krochmal P,
|
||
Hajdu SI</span><br />
|
||
<span class="medgenPMjournal">Ann Clin Lab Sci</span>
|
||
1975 Jul-Aug;5(4):294-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/169727" target="_blank">169727</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wilms%20tumor%204%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32681944">Secondary renal neoplasia following chemotherapy or radiation in pediatric patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gupta S,
|
||
Vanderbilt CM,
|
||
Leibovich BC,
|
||
Herrera-Hernandez L,
|
||
Raghunathan A,
|
||
Sukov WR,
|
||
Voss JS,
|
||
Barr Fritcher EG,
|
||
Reed KA,
|
||
Lohse CM,
|
||
Reuter VE,
|
||
Jimenez RE,
|
||
Thompson RH,
|
||
Cheville JC</span><br />
|
||
<span class="medgenPMjournal">Hum Pathol</span>
|
||
2020 Sep;103:1-13.
|
||
Epub 2020 Jul 15
|
||
doi: 10.1016/j.humpath.2020.07.014.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32681944" target="_blank">32681944</a><a href="/pmc/articles/PMC8935764" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10348288">Anesthesia for pediatric external beam radiation therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fortney JT,
|
||
Halperin EC,
|
||
Hertz CM,
|
||
Schulman SR</span><br />
|
||
<span class="medgenPMjournal">Int J Radiat Oncol Biol Phys</span>
|
||
1999 Jun 1;44(3):587-91.
|
||
doi: 10.1016/s0360-3016(99)00058-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10348288" target="_blank">10348288</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/4330020">Bilateral Wilms tumor: 4-year survival.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Garrett RA,
|
||
Battersby JS</span><br />
|
||
<span class="medgenPMjournal">J Urol</span>
|
||
1971 Dec;106(6):942-6.
|
||
doi: 10.1016/s0022-5347(17)61443-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/4330020" target="_blank">4330020</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wilms%20tumor%204%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35760918">Beyond Wilms tumor: imaging findings and outcomes of rare renal tumors in children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ayaz E,
|
||
Ozcan HN,
|
||
Oguz B,
|
||
Haliloglu M</span><br />
|
||
<span class="medgenPMjournal">Pediatr Radiol</span>
|
||
2022 Dec;52(13):2557-2567.
|
||
Epub 2022 Jun 28
|
||
doi: 10.1007/s00247-022-05422-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35760918" target="_blank">35760918</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23511492">Spinal cord compression in childhood pediatric malignancies: multicenter egyptian study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tantawy AA,
|
||
Ebeid FS,
|
||
Mahmoud MA,
|
||
Shepl OE</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Hematol Oncol</span>
|
||
2013 Apr;35(3):232-6.
|
||
doi: 10.1097/MPH.0b013e318270b210.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23511492" target="_blank">23511492</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10348288">Anesthesia for pediatric external beam radiation therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fortney JT,
|
||
Halperin EC,
|
||
Hertz CM,
|
||
Schulman SR</span><br />
|
||
<span class="medgenPMjournal">Int J Radiat Oncol Biol Phys</span>
|
||
1999 Jun 1;44(3):587-91.
|
||
doi: 10.1016/s0360-3016(99)00058-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10348288" target="_blank">10348288</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6289486">Hepatic resection for secondary neoplasms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Morrow CE,
|
||
Grage TB,
|
||
Sutherland DE,
|
||
Najarian JS</span><br />
|
||
<span class="medgenPMjournal">Surgery</span>
|
||
1982 Oct;92(4):610-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6289486" target="_blank">6289486</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/4330020">Bilateral Wilms tumor: 4-year survival.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Garrett RA,
|
||
Battersby JS</span><br />
|
||
<span class="medgenPMjournal">J Urol</span>
|
||
1971 Dec;106(6):942-6.
|
||
doi: 10.1016/s0022-5347(17)61443-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/4330020" target="_blank">4330020</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wilms%20tumor%204%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5)</a></div></div>
|
||
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||
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|
||
<div class="supplemental col three_col last">
|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C1832426%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (1)</a></li>
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<a href="/pubmed/20301471" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=3" target="_blank"><span class="gene_reviews">GeneReviews</span></a>
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<a href="/pubmed/clinical?term=Wilms%20tumor%204" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=3" target="_blank">PubMed Clinical Queries</a>
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<a href="/pubmed?term=Wilms%20tumor%204%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=3&linkpostotal=3" target="_blank">Reviews in PubMed</a>
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<a class="brieflinkpopperctrl" href="/gtr/tests?term=C1832426[DISCUI]" ref="log$=recordlinks">GTR</a>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67d5a53c84f3725e598d8073">Wilms tumor 4</a>
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<div class="tertiary">MedGen</div>
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<div class="tertiary">MedGen</div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67d5a527cde49f3df73bda89">Wilms Tumor Predisposition - GeneReviews®</a>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67d5a526cde49f3df73bd8aa">Table 2. [Less Common Genes and Syndromes Associated with Wilms Tumor Predisposi...</a>
|
||
<div class="ralinkpop offscreen_noflow">Table 2. [Less Common Genes and Syndromes Associated with Wilms Tumor Predisposition]. - GeneReviews®<div class="brieflinkpopdesc"></div></div>
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<div class="tertiary"></div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67d5a52567c23b31e010e3a8">Table 1. [More Common Genes, Loci, and Syndromes Associated with Wilms Tumor Pre...</a>
|
||
<div class="ralinkpop offscreen_noflow">Table 1. [More Common Genes, Loci, and Syndromes Associated with Wilms Tumor Predisposition]. - GeneReviews®<div class="brieflinkpopdesc"></div></div>
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