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<meta name="keywords" content="C1707448, breast columnar cell lesion, columnar cell lesion of breast, columnar cell lesion of the breast, neoplastic process, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A morphologic spectrum of lesions that arise in the terminal ductal lobular units of the breast parenchyma. These lesions are characterized by the presence of columnar epithelial cells that line dilated terminal ductal lobular units. Cytological and architectural atypia may be absent or minimal, or significant enough to raise the possibility of atypical ductal hyperplasia or ductal carcinoma in situ. Columnar cell lesions are frequently found in breast biopsies but their biologic significance is not known." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Breast Columnar Cell Lesion (Concept Id: C1707448)
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<!--
UID=317529
ConceptID=C1707448
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Breast Columnar Cell Lesion</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>317529</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1707448</a></dd><dt><span class="dotprefix"></span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Columnar Cell Lesion of Breast; Columnar Cell Lesion of the Breast</td></tr>
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">A morphologic spectrum of lesions that arise in the terminal ductal lobular units of the breast parenchyma. These lesions are characterized by the presence of columnar epithelial cells that line dilated terminal ductal lobular units. Cytological and architectural atypia may be absent or minimal, or significant enough to raise the possibility of atypical ductal hyperplasia or ductal carcinoma in situ. Columnar cell lesions are frequently found in breast biopsies but their biologic significance is not known. [from <a title="NCI Thesaurus" href="http://ncit.nci.nih.gov" class="defSource" target="_blank">NCI</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Breast Columnar Cell Lesion</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/871338" ref="tree=MeSH" title="MedGen record for Abnormality of the breast">Abnormality of the breast</a></span><ul><li><span class="TLline"><a href="/medgen/1627648" ref="tree=MeSH" title="MedGen record for Abnormal breast morphology">Abnormal breast morphology</a></span><ul><li><span class="TLline"><a href="/medgen/264172" ref="tree=MeSH" title="MedGen record for Breast neoplasm">Breast neoplasm</a></span><ul><li><span class="matched_ds">Breast Columnar Cell Lesion</span><ul><li><span class="TLline"><a href="/medgen/353552" ref="tree=MeSH" title="MedGen record for Columnar Cell Change of the Breast">Columnar Cell Change of the Breast</a></span><ul><li><span class="TLline"><a href="/medgen/310622" ref="tree=MeSH" title="MedGen record for Columnar Cell Change of the Breast with Atypia">Columnar Cell Change of the Breast with Atypia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/310623" ref="tree=MeSH" title="MedGen record for Columnar cell hyperplasia of the breast">Columnar cell hyperplasia of the breast</a></span><ul><li><span class="TLline"><a href="/medgen/317528" ref="tree=MeSH" title="MedGen record for Breast Columnar Cell Hyperplasia with Atypia">Breast Columnar Cell Hyperplasia with Atypia</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/32174198">Pitfalls and controversies in pathology impacting breast cancer management.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kim WG,
Cummings MC,
Lakhani SR</span><br />
<span class="medgenPMjournal">Expert Rev Anticancer Ther</span>
2020 Mar;20(3):205-219.
Epub 2020 Mar 14
doi: 10.1080/14737140.2020.1738222.
<span class="bold">PMID: </span><a href="/pubmed/32174198" target="_blank">32174198</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24684875">Diagnosis and management of benign, atypical, and indeterminate breast lesions detected on core needle biopsy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Neal L,
Sandhu NP,
Hieken TJ,
Glazebrook KN,
Mac Bride MB,
Dilaveri CA,
Wahner-Roedler DL,
Ghosh K,
Visscher DW</span><br />
<span class="medgenPMjournal">Mayo Clin Proc</span>
2014 Apr;89(4):536-47.
doi: 10.1016/j.mayocp.2014.02.004.
<span class="bold">PMID: </span><a href="/pubmed/24684875" target="_blank">24684875</a></div>
<div class="nl"><a target="_blank" href="/pubmed/12927037">The diagnosis and management of pre-invasive breast disease: flat epithelial atypia--classification, pathologic features and clinical significance.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Schnitt SJ</span><br />
<span class="medgenPMjournal">Breast Cancer Res</span>
2003;5(5):263-8.
Epub 2003 Jul 29
doi: 10.1186/bcr625.
<span class="bold">PMID: </span><a href="/pubmed/12927037" target="_blank">12927037</a><a href="/pmc/articles/PMC314429" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(breast%20columnar%20cell%20lesion)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (12)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/36005185">Are Columnar Cell Lesions the Earliest Non-Obligate Precursor in the Low-Grade Breast Neoplasia Pathway?</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Strickland S,
Turashvili G</span><br />
<span class="medgenPMjournal">Curr Oncol</span>
2022 Aug 11;29(8):5664-5681.
doi: 10.3390/curroncol29080447.
<span class="bold">PMID: </span><a href="/pubmed/36005185" target="_blank">36005185</a><a href="/pmc/articles/PMC9406596" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24684875">Diagnosis and management of benign, atypical, and indeterminate breast lesions detected on core needle biopsy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Neal L,
Sandhu NP,
Hieken TJ,
Glazebrook KN,
Mac Bride MB,
Dilaveri CA,
Wahner-Roedler DL,
Ghosh K,
Visscher DW</span><br />
<span class="medgenPMjournal">Mayo Clin Proc</span>
2014 Apr;89(4):536-47.
doi: 10.1016/j.mayocp.2014.02.004.
<span class="bold">PMID: </span><a href="/pubmed/24684875" target="_blank">24684875</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19089736">Columnar cell lesions of the breast: an update and significance on core biopsy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Jara-Lazaro AR,
Tse GM,
Tan PH</span><br />
<span class="medgenPMjournal">Pathology</span>
2009 Jan;41(1):18-27.
doi: 10.1080/00313020802563486.
<span class="bold">PMID: </span><a href="/pubmed/19089736" target="_blank">19089736</a></div>
<div class="nl"><a target="_blank" href="/pubmed/15337418">Pathology of high-risk breast lesions and ductal carcinoma in situ.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sewell CW</span><br />
<span class="medgenPMjournal">Radiol Clin North Am</span>
2004 Sep;42(5):821-30, v.
doi: 10.1016/j.rcl.2004.03.013.
<span class="bold">PMID: </span><a href="/pubmed/15337418" target="_blank">15337418</a></div>
<div class="nl"><a target="_blank" href="/pubmed/12927037">The diagnosis and management of pre-invasive breast disease: flat epithelial atypia--classification, pathologic features and clinical significance.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Schnitt SJ</span><br />
<span class="medgenPMjournal">Breast Cancer Res</span>
2003;5(5):263-8.
Epub 2003 Jul 29
doi: 10.1186/bcr625.
<span class="bold">PMID: </span><a href="/pubmed/12927037" target="_blank">12927037</a><a href="/pmc/articles/PMC314429" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Breast%20Columnar%20Cell%20Lesion%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (90)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/36693714">Papillomatous breast lesions with atypical columnar cell features.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">de Boer M,
Verschuur-Maes AHJ,
Moelans C,
van Diest PJ</span><br />
<span class="medgenPMjournal">J Clin Pathol</span>
2023 Apr;76(4):228-233.
Epub 2023 Jan 24
doi: 10.1136/jcp-2022-208389.
<span class="bold">PMID: </span><a href="/pubmed/36693714" target="_blank">36693714</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36005185">Are Columnar Cell Lesions the Earliest Non-Obligate Precursor in the Low-Grade Breast Neoplasia Pathway?</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Strickland S,
Turashvili G</span><br />
<span class="medgenPMjournal">Curr Oncol</span>
2022 Aug 11;29(8):5664-5681.
doi: 10.3390/curroncol29080447.
<span class="bold">PMID: </span><a href="/pubmed/36005185" target="_blank">36005185</a><a href="/pmc/articles/PMC9406596" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32174198">Pitfalls and controversies in pathology impacting breast cancer management.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kim WG,
Cummings MC,
Lakhani SR</span><br />
<span class="medgenPMjournal">Expert Rev Anticancer Ther</span>
2020 Mar;20(3):205-219.
Epub 2020 Mar 14
doi: 10.1080/14737140.2020.1738222.
<span class="bold">PMID: </span><a href="/pubmed/32174198" target="_blank">32174198</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24684875">Diagnosis and management of benign, atypical, and indeterminate breast lesions detected on core needle biopsy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Neal L,
Sandhu NP,
Hieken TJ,
Glazebrook KN,
Mac Bride MB,
Dilaveri CA,
Wahner-Roedler DL,
Ghosh K,
Visscher DW</span><br />
<span class="medgenPMjournal">Mayo Clin Proc</span>
2014 Apr;89(4):536-47.
doi: 10.1016/j.mayocp.2014.02.004.
<span class="bold">PMID: </span><a href="/pubmed/24684875" target="_blank">24684875</a></div>
<div class="nl"><a target="_blank" href="/pubmed/12927037">The diagnosis and management of pre-invasive breast disease: flat epithelial atypia--classification, pathologic features and clinical significance.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Schnitt SJ</span><br />
<span class="medgenPMjournal">Breast Cancer Res</span>
2003;5(5):263-8.
Epub 2003 Jul 29
doi: 10.1186/bcr625.
<span class="bold">PMID: </span><a href="/pubmed/12927037" target="_blank">12927037</a><a href="/pmc/articles/PMC314429" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Breast%20Columnar%20Cell%20Lesion%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (117)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/32939016">Testosterone therapy and breast histopathological features in transgender individuals.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Baker GM,
Guzman-Arocho YD,
Bret-Mounet VC,
Torous VF,
Schnitt SJ,
Tobias AM,
Bartlett RA,
Fein-Zachary VJ,
Collins LC,
Wulf GM,
Heng YJ</span><br />
<span class="medgenPMjournal">Mod Pathol</span>
2021 Jan;34(1):85-94.
Epub 2020 Sep 16
doi: 10.1038/s41379-020-00675-9.
<span class="bold">PMID: </span><a href="/pubmed/32939016" target="_blank">32939016</a><a href="/pmc/articles/PMC7854981" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29084054">Columnar Cell Lesion and Apocrine Hyperplasia of the Breast: Is There a Common Origin? The Role of Prolactin-induced Protein.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sciarra A,
Lopez G,
Corti C,
Runza L,
Ercoli G,
Bonometti A,
Despini L,
Blundo C,
Gambini D,
Fusco N</span><br />
<span class="medgenPMjournal">Appl Immunohistochem Mol Morphol</span>
2019 Aug;27(7):508-514.
doi: 10.1097/PAI.0000000000000604.
<span class="bold">PMID: </span><a href="/pubmed/29084054" target="_blank">29084054</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25083895">HPV and cervical cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Petry KU</span><br />
<span class="medgenPMjournal">Scand J Clin Lab Invest Suppl</span>
2014;244:59-62; discussion 62.
doi: 10.3109/00365513.2014.936683.
<span class="bold">PMID: </span><a href="/pubmed/25083895" target="_blank">25083895</a></div>
<div class="nl"><a target="_blank" href="/pubmed/20084540">A multi-center prospective cohort study of benign breast disease and risk of subsequent breast cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kabat GC,
Jones JG,
Olson N,
Negassa A,
Duggan C,
Ginsberg M,
Kandel RA,
Glass AG,
Rohan TE</span><br />
<span class="medgenPMjournal">Cancer Causes Control</span>
2010 Jun;21(6):821-8.
Epub 2010 Jan 19
doi: 10.1007/s10552-010-9508-7.
<span class="bold">PMID: </span><a href="/pubmed/20084540" target="_blank">20084540</a><a href="/pmc/articles/PMC2873161" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/18587641">Columnar cell lesions, mammographic density and breast cancer risk.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Turashvili G,
McKinney S,
Martin L,
Gelmon KA,
Watson P,
Boyd N,
Aparicio S</span><br />
<span class="medgenPMjournal">Breast Cancer Res Treat</span>
2009 Jun;115(3):561-71.
Epub 2008 Jun 28
doi: 10.1007/s10549-008-0099-x.
<span class="bold">PMID: </span><a href="/pubmed/18587641" target="_blank">18587641</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Breast%20Columnar%20Cell%20Lesion%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/36005185">Are Columnar Cell Lesions the Earliest Non-Obligate Precursor in the Low-Grade Breast Neoplasia Pathway?</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Strickland S,
Turashvili G</span><br />
<span class="medgenPMjournal">Curr Oncol</span>
2022 Aug 11;29(8):5664-5681.
doi: 10.3390/curroncol29080447.
<span class="bold">PMID: </span><a href="/pubmed/36005185" target="_blank">36005185</a><a href="/pmc/articles/PMC9406596" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32174198">Pitfalls and controversies in pathology impacting breast cancer management.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kim WG,
Cummings MC,
Lakhani SR</span><br />
<span class="medgenPMjournal">Expert Rev Anticancer Ther</span>
2020 Mar;20(3):205-219.
Epub 2020 Mar 14
doi: 10.1080/14737140.2020.1738222.
<span class="bold">PMID: </span><a href="/pubmed/32174198" target="_blank">32174198</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24760612">Positive predictive value for malignancy of pure flat epithelial atypia diagnosis by percutaneous needle biopsy of the breast: management of FEA in ultrasonography.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Maeda I,
Kanemaki Y,
Tozaki M,
Koizumi H,
Oana Y,
Okanami Y,
Tsuchiya K,
Shimo A,
Kojima Y,
Hayami R,
Nishikawa T,
Kawamoto H,
Yabuki Y,
Tsugawa K,
Takagi M</span><br />
<span class="medgenPMjournal">Breast Cancer</span>
2015 Nov;22(6):634-40.
Epub 2014 Apr 24
doi: 10.1007/s12282-014-0530-6.
<span class="bold">PMID: </span><a href="/pubmed/24760612" target="_blank">24760612</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23922357">Columnar cell-like changes in the male breast.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ni YB,
Mujtaba S,
Shao MM,
Lacambra M,
Tsang JY,
Chan SK,
Tse GM</span><br />
<span class="medgenPMjournal">J Clin Pathol</span>
2014 Jan;67(1):45-8.
Epub 2013 Aug 6
doi: 10.1136/jclinpath-2013-201631.
<span class="bold">PMID: </span><a href="/pubmed/23922357" target="_blank">23922357</a></div>
<div class="nl"><a target="_blank" href="/pubmed/11710639">Morphological observations regarding the origins of atypical cystic lobules (low-grade clinging carcinoma of flat type).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Koerner FC,
Oyama T,
Maluf H</span><br />
<span class="medgenPMjournal">Virchows Arch</span>
2001 Oct;439(4):523-30.
doi: 10.1007/s004280100426.
<span class="bold">PMID: </span><a href="/pubmed/11710639" target="_blank">11710639</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Breast%20Columnar%20Cell%20Lesion%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (43)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/32174198">Pitfalls and controversies in pathology impacting breast cancer management.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kim WG,
Cummings MC,
Lakhani SR</span><br />
<span class="medgenPMjournal">Expert Rev Anticancer Ther</span>
2020 Mar;20(3):205-219.
Epub 2020 Mar 14
doi: 10.1080/14737140.2020.1738222.
<span class="bold">PMID: </span><a href="/pubmed/32174198" target="_blank">32174198</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24760612">Positive predictive value for malignancy of pure flat epithelial atypia diagnosis by percutaneous needle biopsy of the breast: management of FEA in ultrasonography.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Maeda I,
Kanemaki Y,
Tozaki M,
Koizumi H,
Oana Y,
Okanami Y,
Tsuchiya K,
Shimo A,
Kojima Y,
Hayami R,
Nishikawa T,
Kawamoto H,
Yabuki Y,
Tsugawa K,
Takagi M</span><br />
<span class="medgenPMjournal">Breast Cancer</span>
2015 Nov;22(6):634-40.
Epub 2014 Apr 24
doi: 10.1007/s12282-014-0530-6.
<span class="bold">PMID: </span><a href="/pubmed/24760612" target="_blank">24760612</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22813732">Current issues in diagnostic breast pathology.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Walker RA,
Hanby A,
Pinder SE,
Thomas J,
Ellis IO;
National Coordinating Committee for Breast Pathology Research Subgroup</span><br />
<span class="medgenPMjournal">J Clin Pathol</span>
2012 Sep;65(9):771-85.
Epub 2012 Jul 19
doi: 10.1136/jclinpath-2012-200733.
<span class="bold">PMID: </span><a href="/pubmed/22813732" target="_blank">22813732</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21490436">Borderline breast lesions: diagnostic challenges and clinical implications.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Masood S,
Rosa M</span><br />
<span class="medgenPMjournal">Adv Anat Pathol</span>
2011 May;18(3):190-8.
doi: 10.1097/PAP.0b013e31821698cc.
<span class="bold">PMID: </span><a href="/pubmed/21490436" target="_blank">21490436</a></div>
<div class="nl"><a target="_blank" href="/pubmed/17182657">Non-operative breast pathology: columnar cell lesions.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pinder SE,
Reis-Filho JS</span><br />
<span class="medgenPMjournal">J Clin Pathol</span>
2007 Dec;60(12):1307-12.
Epub 2006 Dec 20
doi: 10.1136/jcp.2006.040634.
<span class="bold">PMID: </span><a href="/pubmed/17182657" target="_blank">17182657</a><a href="/pmc/articles/PMC2095568" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Breast%20Columnar%20Cell%20Lesion%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (58)</a></div></div>
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<div class="nl"><a target="_blank" href="/pubmed/21989373">Columnar cell lesions on breast needle biopsies: is surgical excision necessary? A systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Verschuur-Maes AH,
van Deurzen CH,
Monninkhof EM,
van Diest PJ</span><br />
<span class="medgenPMjournal">Ann Surg</span>
2012 Feb;255(2):259-65.
doi: 10.1097/SLA.0b013e318233523f.
<span class="bold">PMID: </span><a href="/pubmed/21989373" target="_blank">21989373</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Breast%20Columnar%20Cell%20Lesion%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(breast%20columnar%20cell%20lesion)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Breast%20Columnar%20Cell%20Lesion%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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