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<meta name="keywords" content="C1563719, anos1, anos1 hypogonadotropic hypogonadism, anosmic hypogonadism, disease or syndrome, dysplasia olfactogenitalis of de morsier, hh1, hypogonadotropic hypogonadism 1 with anosmia, hypogonadotropic hypogonadism 1 with or without anosmia, hypogonadotropic hypogonadism 1 with or without anosmia (kallmann syndrome 1), hypogonadotropic hypogonadism 1 with or without anosmia (kallmann syndrome 1), x-linked recessive, hypogonadotropic hypogonadism and anosmia, hypogonadotropic hypogonadism caused by mutation in anos1, kal1, kallmann syndrome 1, kallmann syndrome, type 1, x-linked, kallmann syndrome, x-linked, kms, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=295872
|
||
ConceptID=C1563719
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-->
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<!--imgCountBooks = 4--><div class="ncbi_carousel" data-ncbicarousel-config="imageWidth:'100px',numItemsVisible:2,toggler:false"><div class="nc_header"><span class="img_strip_title">Images (4)</span></div><div class="nc_content"><div class="nc_item"><a class="figpopup"><img alt="Image from GeneReviews" src="/books/NBK1334/bin/kms-Image003.gif" src-large="/books/NBK1334/bin/kms-Image003.jpg" /></a><br /><a href="/books/NBK1334/figure/kms.F3/" title="GeneReviews" target="_blank">details</a></div><div class="nc_item"><a class="figpopup"><img alt="Image from GeneReviews" src="/books/NBK1334/bin/kms-Image001.gif" src-large="/books/NBK1334/bin/kms-Image001.jpg" /></a><br /><a href="/books/NBK1334/figure/kms.F1/" title="GeneReviews" target="_blank">details</a></div><div class="nc_item"><a class="figpopup"><img alt="Image from GeneReviews" src="/books/NBK1334/bin/kms-Image002.gif" src-large="/books/NBK1334/bin/kms-Image002.jpg" /></a><br /><a href="/books/NBK1334/figure/kms.F2/" title="GeneReviews" target="_blank">details</a></div><div class="nc_item"><a class="figpopup"><img alt="Image from GeneReviews" src="/books/NBK1334/bin/kms-Image004.gif" src-large="/books/NBK1334/bin/kms-Image004.jpg" /></a><br /><a href="/books/NBK1334/figure/kms.F4/" title="GeneReviews" target="_blank">details</a></div></div></div><h1 class="medgenTitle"><div class="MedGenTitleText">Hypogonadotropic hypogonadism 1 with or without anosmia<span class="h1sub">(HH1)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>295872</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1563719</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>DYSPLASIA OLFACTOGENITALIS OF DE MORSIER; HH1; HYPOGONADOTROPIC HYPOGONADISM 1 WITH ANOSMIA; Hypogonadotropic hypogonadism 1 with or without anosmia (Kallmann syndrome 1); HYPOGONADOTROPIC HYPOGONADISM AND ANOSMIA; Kallmann syndrome, type 1, X-linked</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="ANOS1 - ID: 3730 - NCBI Gene" href="/gene/3730" class="medgenPMinfo">ANOS1</a> (Xp22.31)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0010635" target="_blank">MONDO:0010635</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/308700" target="_blank">308700</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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||
<div class="portlet mgSection" id="ID_101">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Disease_characteristics">Disease characteristics</h1><a sid="101" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="excerpt">Excerpted from the <i>GeneReview: </i><a href="/books/NBK1334" target="_blank">Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency</a></div><div>Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt. [from <a title="GeneReviews" href="https://www.ncbi.nlm.nih.gov/books/NBK1116" class="defSource" target="_blank">GeneReviews</a>]</div><div class="spaceAbove"><strong>Full text of <i>GeneReview</i> (by section):</strong><br /><a class="medgenPMinfo" href="/books/NBK1334#kms.Summary" target="NBK1334">Summary</a> | <a class="medgenPMinfo" href="/books/NBK1334#kms.GeneReview_Scope" target="NBK1334">GeneReview Scope</a> | <a class="medgenPMinfo" href="/books/NBK1334#kms.Diagnosis" target="NBK1334">Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK1334#kms.Clinical_Characteristics" target="NBK1334">Clinical Characteristics</a> | <a class="medgenPMinfo" href="/books/NBK1334#kms.Genetically_Related_Allelic_Disorder" target="NBK1334">Genetically Related (Allelic) Disorders</a> | <a class="medgenPMinfo" href="/books/NBK1334#kms.Differential_Diagnosis" target="NBK1334">Differential Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK1334#kms.Management" target="NBK1334">Management</a> | <a class="medgenPMinfo" href="/books/NBK1334#kms.Genetic_Counseling" target="NBK1334">Genetic Counseling</a> | <a class="medgenPMinfo" href="/books/NBK1334#kms.Resources" target="NBK1334">Resources</a> | <a class="medgenPMinfo" href="/books/NBK1334#kms.Molecular_Genetics" target="NBK1334">Molecular Genetics</a> | <a class="medgenPMinfo" href="/books/NBK1334#kms.Chapter_Notes" target="NBK1334">Chapter Notes</a> | <a class="medgenPMinfo" href="/books/NBK1334#kms.References" target="NBK1334">References</a></div><div class="spaceAbove"><strong>Authors:</strong><br />
|
||
Ravikumar Balasubramanian | William F Crowley <a href="/books/NBK1334" target="NBK1334" title="NCBI Bookshelf: Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency">view full author information</a></div></div>
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<div class="portlet mgSection" id="ID_117">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Additional_descriptions">Additional descriptions</h1><a sid="117" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="mgSection"><strong>From OMIM</strong><br />Congenital idiopathic hypogonadotropic hypogonadism (IHH) is a disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. Idiopathic hypogonadotropic hypogonadism can be caused by an isolated defect in gonadotropin-releasing hormone (GNRH; 152760) release, action, or both. Other associated nonreproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss, occur with variable frequency. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism has been called 'Kallmann syndrome (KS),' whereas in the presence of a normal sense of smell, it has been termed 'normosmic idiopathic hypogonadotropic hypogonadism (nIHH)' (summary by Raivio et al., 2007). Because families have been found to segregate both KS and nIHH, the disorder is here referred to as 'hypogonadotropic hypogonadism with or without anosmia.'
|
||
For information on the autosomal forms of hypogonadotropic hypogonadism with or without anosmia, see 147950. <a target="_blank" href="http://www.omim.org/entry/308700">http://www.omim.org/entry/308700</a></div><div class="mgSection"><strong>From MedlinePlus Genetics</strong><br />In Kallmann syndrome, the sense of smell is either diminished (hyposmia) or completely absent (anosmia). This feature distinguishes Kallmann syndrome from most other forms of hypogonadotropic hypogonadism, which do not affect the sense of smell. Many people with Kallmann syndrome are not aware that they are unable to detect odors until the impairment is discovered through testing.<br /><br />Kallmann syndrome can have a wide variety of additional signs and symptoms. These include a failure of one kidney to develop (unilateral renal agenesis), abnormalities of bones in the fingers or toes, a cleft lip with or without an opening in the roof of the mouth (a cleft palate), abnormal eye movements, hearing loss, and abnormalities of tooth development. Some affected individuals have a feature called bimanual synkinesis, in which the movements of one hand are mirrored by the other hand. Bimanual synkinesis can make it difficult to do tasks that require the hands to move separately, such as playing a musical instrument.<br /><br />This disorder is a form of hypogonadotropic hypogonadism, which is a condition resulting from a lack of production of certain hormones that direct sexual development. These hormones are normally made in a part of the brain called the hypothalamus. Males born with hypogonadotropic hypogonadism often have an unusually small penis (micropenis) and undescended testes (cryptorchidism). At puberty, most affected individuals do not develop secondary sex characteristics, such as the growth of facial hair and deepening of the voice in males, the start of monthly periods (menstruation) and breast development in females, and a growth spurt in both sexes. Without treatment, most affected men and women are unable to have biological children (infertile).<br /><br />Kallmann syndrome is a condition characterized by delayed or absent puberty and an impaired sense of smell. <a target="_blank" href="https://medlineplus.gov/genetics/condition/kallmann-syndrome">https://medlineplus.gov/genetics/condition/kallmann-syndrome</a></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
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<div class="divPopper rprt" id="clin_2150"><div><strong>Azoospermia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>2150</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0004509</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Absence of any measurable level of sperm,whereby spermatozoa cannot be observed even after centrifugation of the semen pellet.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/2150">Feature record</a> | <a href="/medgen?term=%22Azoospermia%22%5BClinical%20Features%5D%20OR%202150%5Buid%5D">Search on this feature</a></div></div>
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<div class="divPopper rprt" id="clin_8192"><div><strong>Cryptorchidism</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>8192</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0010417</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
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<div class="spaceAbove">Cryptorchidism, or failure of testicular descent, is a common human congenital abnormality with a multifactorial etiology that likely reflects the involvement of endocrine, environmental, and hereditary factors. Cryptorchidism can result in infertility and increases risk for testicular tumors. Testicular descent from abdomen to scrotum occurs in 2 distinct phases: the transabdominal phase and the inguinoscrotal phase (summary by Gorlov et al., 2002).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/8192">Feature record</a> | <a href="/medgen?term=%22Cryptorchidism%22%5BClinical%20Features%5D%20OR%208192%5Buid%5D">Search on this feature</a></div></div>
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<div class="divPopper rprt" id="clin_57626"><div><strong>Testicular atrophy</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>57626</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0156312</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Wasting (atrophy) of the testicle (the male gonad) manifested by a decrease in size and potentially by a loss of fertility.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/57626">Feature record</a> | <a href="/medgen?term=%22Testicular%20atrophy%22%5BClinical%20Features%5D%20OR%2057626%5Buid%5D">Search on this feature</a></div></div>
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<div class="divPopper rprt" id="clin_66027"><div><strong>Decreased testicular size</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>66027</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0241355</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">Reduced volume of the testicle (the male gonad).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/66027">Feature record</a> | <a href="/medgen?term=%22Decreased%20testicular%20size%22%5BClinical%20Features%5D%20OR%2066027%5Buid%5D">Search on this feature</a></div></div>
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<div class="divPopper rprt" id="clin_75607"><div><strong>Unilateral renal agenesis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>75607</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0266294</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
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<div class="spaceAbove">A unilateral form of agenesis of the kidney.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/75607">Feature record</a> | <a href="/medgen?term=%22Unilateral%20renal%20agenesis%22%5BClinical%20Features%5D%20OR%2075607%5Buid%5D">Search on this feature</a></div></div>
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<div class="divPopper rprt" id="clin_141577"><div><strong>Small scrotum</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>141577</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0455792</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">Apparently small scrotum for age.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/141577">Feature record</a> | <a href="/medgen?term=%22Small%20scrotum%22%5BClinical%20Features%5D%20OR%20141577%5Buid%5D">Search on this feature</a></div></div>
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<div class="divPopper rprt" id="clin_1633603"><div><strong>Micropenis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1633603</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4551492</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
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<div class="spaceAbove">Abnormally small penis. At birth, the normal penis is about 3 cm (stretched length from pubic tubercle to tip of penis) with micropenis less than 2.0-2.5 cm.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/1633603">Feature record</a> | <a href="/medgen?term=%22Micropenis%22%5BClinical%20Features%5D%20OR%201633603%5Buid%5D">Search on this feature</a></div></div>
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<div class="divPopper rprt" id="clin_675590"><div><strong>Pes cavus</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>675590</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0728829</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
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<div class="spaceAbove">An increase in height of the medial longitudinal arch of the foot that does not flatten on weight bearing (i.e., a distinctly hollow form of the sole of the foot when it is bearing weight).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/675590">Feature record</a> | <a href="/medgen?term=%22Pes%20cavus%22%5BClinical%20Features%5D%20OR%20675590%5Buid%5D">Search on this feature</a></div></div>
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<div class="divPopper rprt" id="clin_871104"><div><strong>Eunuchoid habitus</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>871104</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4025569</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">A body habitus that is tall, slim and underweight, with long legs and long arms (i.e., arm span exceeds height by 5 cm or more).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/871104">Feature record</a> | <a href="/medgen?term=%22Eunuchoid%20habitus%22%5BClinical%20Features%5D%20OR%20871104%5Buid%5D">Search on this feature</a></div></div>
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<div class="divPopper rprt" id="clin_1950"><div><strong>Anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1950</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0003126</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">An inability to perceive odors. This is a general term describing inability to smell arising in any part of the process of smelling from absorption of odorants into the nasal mucous overlying the olfactory epithelium, diffusion to the cilia, binding to olfactory receptor sites, generation of action potentials in olfactory neurons, and perception of a smell.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/1950">Feature record</a> | <a href="/medgen?term=%22Anosmia%22%5BClinical%20Features%5D%20OR%201950%5Buid%5D">Search on this feature</a></div></div>
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<div class="divPopper rprt" id="clin_849"><div><strong>Cerebellar ataxia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>849</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0007758</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Cerebellar ataxia refers to ataxia due to dysfunction of the cerebellum. This causes a variety of elementary neurological deficits including asynergy (lack of coordination between muscles, limbs and joints), dysmetria (lack of ability to judge distances that can lead to under- or overshoot in grasping movements), and dysdiadochokinesia (inability to perform rapid movements requiring antagonizing muscle groups to be switched on and off repeatedly).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/849">Feature record</a> | <a href="/medgen?term=%22Cerebellar%20ataxia%22%5BClinical%20Features%5D%20OR%20849%5Buid%5D">Search on this feature</a></div></div>
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<div class="divPopper rprt" id="clin_473166"><div><strong>Bimanual synkinesia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>473166</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0454455</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Involuntary movements of one hand that accompany and mirror intentional movements of the opposite hand.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/473166">Feature record</a> | <a href="/medgen?term=%22Bimanual%20synkinesia%22%5BClinical%20Features%5D%20OR%20473166%5Buid%5D">Search on this feature</a></div></div>
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<div class="divPopper rprt" id="clin_344477"><div><strong>Olfactory lobe agenesis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>344477</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1855331</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/344477">Feature record</a> | <a href="/medgen?term=%22Olfactory%20lobe%20agenesis%22%5BClinical%20Features%5D%20OR%20344477%5Buid%5D">Search on this feature</a></div></div>
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<div class="divPopper rprt" id="clin_473584"><div><strong>Hyposmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>473584</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2364082</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">A decreased sensitivity to odorants (that is, a decreased ability to perceive odors).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/473584">Feature record</a> | <a href="/medgen?term=%22Hyposmia%22%5BClinical%20Features%5D%20OR%20473584%5Buid%5D">Search on this feature</a></div></div>
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<div class="divPopper rprt" id="clin_66814"><div><strong>High palate</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>66814</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0240635</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
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<div class="spaceAbove">Height of the palate more than 2 SD above the mean (objective) or palatal height at the level of the first permanent molar more than twice the height of the teeth (subjective).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/66814">Feature record</a> | <a href="/medgen?term=%22High%20palate%22%5BClinical%20Features%5D%20OR%2066814%5Buid%5D">Search on this feature</a></div></div>
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<div class="divPopper rprt" id="clin_266298"><div><strong>Facial asymmetry</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>266298</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1306710</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">An abnormal difference between the left and right sides of the face.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/266298">Feature record</a> | <a href="/medgen?term=%22Facial%20asymmetry%22%5BClinical%20Features%5D%20OR%20266298%5Buid%5D">Search on this feature</a></div></div>
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<div class="divPopper rprt" id="clin_388095"><div><strong>Sparse pubic hair</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>388095</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1858573</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">Reduced number or density of pubic hair.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/388095">Feature record</a> | <a href="/medgen?term=%22Sparse%20pubic%20hair%22%5BClinical%20Features%5D%20OR%20388095%5Buid%5D">Search on this feature</a></div></div>
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<div class="divPopper rprt" id="clin_82883"><div><strong>Hypogonadotropic hypogonadism</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>82883</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0271623</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Hypogonadotropic hypogonadism is characterized by reduced function of the gonads (testes in males or ovaries in females) and results from the absence of the gonadal stimulating pituitary hormones</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/82883">Feature record</a> | <a href="/medgen?term=%22Hypogonadotropic%20hypogonadism%22%5BClinical%20Features%5D%20OR%2082883%5Buid%5D">Search on this feature</a></div></div>
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<div class="divPopper rprt" id="clin_871170"><div><strong>Hypothalamic gonadotropin-releasing hormone deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>871170</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4025644</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/871170">Feature record</a> | <a href="/medgen?term=%22Hypothalamic%20gonadotropin-releasing%20hormone%20deficiency%22%5BClinical%20Features%5D%20OR%20871170%5Buid%5D">Search on this feature</a></div></div>
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<div class="divPopper rprt" id="clin_871191"><div><strong>Leydig cell insensitivity to gonadotropin</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>871191</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4025668</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/871191">Feature record</a> | <a href="/medgen?term=%22Leydig%20cell%20insensitivity%20to%20gonadotropin%22%5BClinical%20Features%5D%20OR%20871191%5Buid%5D">Search on this feature</a></div></div>
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<div class="divPopper rprt" id="clin_892977"><div><strong>Decreased circulating follicle stimulating hormone concentration</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>892977</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4072889</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">A reduction of the circulating level of follicle-stimulating hormone (FSH).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/892977">Feature record</a> | <a href="/medgen?term=%22Decreased%20circulating%20follicle%20stimulating%20hormone%20concentration%22%5BClinical%20Features%5D%20OR%20892977%5Buid%5D">Search on this feature</a></div></div>
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||
<div class="divPopper rprt" id="clin_893008"><div><strong>Decreased circulating luteinizing hormone level</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>893008</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4072890</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">A reduction in the circulating level of luteinizing hormone (LH).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/893008">Feature record</a> | <a href="/medgen?term=%22Decreased%20circulating%20luteinizing%20hormone%20level%22%5BClinical%20Features%5D%20OR%20893008%5Buid%5D">Search on this feature</a></div></div>
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||
<div class="divPopper rprt" id="clin_892974"><div><strong>Decreased serum testosterone concentration</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>892974</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4073137</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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||
<div class="spaceAbove nowrap">See: <a href="/medgen/892974">Feature record</a> | <a href="/medgen?term=%22Decreased%20serum%20testosterone%20concentration%22%5BClinical%20Features%5D%20OR%20892974%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_6694"><div><strong>Gynecomastia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>6694</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0018418</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">Abnormal development of large mammary glands in males resulting in breast enlargement.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/6694">Feature record</a> | <a href="/medgen?term=%22Gynecomastia%22%5BClinical%20Features%5D%20OR%206694%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of head or neck</span><ul><li class="TLline">
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||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_266298" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Facial asymmetry</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_66814" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">High palate</a></span></li></ul></li><li><span class="TLline">Abnormality of limbs</span><ul><li class="TLline">
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||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_675590" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pes cavus</a></span></li></ul></li><li><span class="TLline">Abnormality of the breast</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_6694" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Gynecomastia</a></span></li></ul></li><li><span class="TLline">Abnormality of the endocrine system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_892977" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Decreased circulating follicle stimulating hormone concentration</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_893008" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Decreased circulating luteinizing hormone level</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_892974" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Decreased serum testosterone concentration</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_82883" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_871170" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypothalamic gonadotropin-releasing hormone deficiency</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_871191" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Leydig cell insensitivity to gonadotropin</a></span></li></ul></li><li><span class="TLline">Abnormality of the genitourinary system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_2150" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Azoospermia</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_8192" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cryptorchidism</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_66027" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Decreased testicular size</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1633603" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Micropenis</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_141577" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Small scrotum</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_57626" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Testicular atrophy</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_75607" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Unilateral renal agenesis</a></span></li></ul></li><li><span class="TLline">Abnormality of the integument</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_388095" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Sparse pubic hair</a></span></li></ul></li><li><span class="TLline">Abnormality of the nervous system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1950" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Anosmia</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_473166" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bimanual synkinesia</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_849" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cerebellar ataxia</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_473584" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hyposmia</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_344477" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Olfactory lobe agenesis</a></span></li></ul></li><li><span class="TLline">Growth abnormality</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_871104" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Eunuchoid habitus</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0162809[DISCUI]&test_type=Clinical" ref="ncbi_uid=102469">C</a></span><span class="chiclet Rcolor round" title="Research test"><a target="_blank" href="/gtr/tests/?term=C0162809[DISCUI]&test_type=Research" ref="ncbi_uid=102469">R</a></span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=102469" target="_blank" href="/omim/308700">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1334/" ref="ncbi_uid=102469">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=102469" ref="ncbi_uid=102469">V</a></span></span><span class="TLline"><a href="/medgen/102469" ref="tree=GTR&ncbi_uid=102469&link_uid=102469" title="View MedGen record for 'Hypogonadism with anosmia'">Hypogonadism with anosmia</a></span><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1563719[DISCUI]&test_type=Clinical" ref="ncbi_uid=295872">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=295872" target="_blank" href="/omim/308700">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1334/" ref="ncbi_uid=295872">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=295872" ref="ncbi_uid=295872">V</a></span></span><span class="TLline">Hypogonadotropic hypogonadism 1 with or without anosmia</span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1563720[DISCUI]&test_type=Clinical" ref="ncbi_uid=289648">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=289648" target="_blank" href="/omim/147950">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1334/" ref="ncbi_uid=289648">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=289648" ref="ncbi_uid=289648">V</a></span></span><span class="TLline"><a href="/medgen/289648" ref="tree=GTR&ncbi_uid=289648&link_uid=289648" title="View MedGen record for 'Hypogonadotropic hypogonadism 2 with or without anosmia'">Hypogonadotropic hypogonadism 2 with or without anosmia</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3550478[DISCUI]&test_type=Clinical" ref="ncbi_uid=763392">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=763392" target="_blank" href="/omim/244200">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1334/" ref="ncbi_uid=763392">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=763392" ref="ncbi_uid=763392">V</a></span></span><span class="TLline"><a href="/medgen/763392" ref="tree=GTR&ncbi_uid=763392&link_uid=763392" title="View MedGen record for 'Hypogonadotropic hypogonadism 3 with or without anosmia'">Hypogonadotropic hypogonadism 3 with or without anosmia</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3552343[DISCUI]&test_type=Clinical" ref="ncbi_uid=765257">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=765257" target="_blank" href="/omim/607002">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1334/" ref="ncbi_uid=765257">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=765257" ref="ncbi_uid=765257">V</a></span></span><span class="TLline"><a href="/medgen/765257" ref="tree=GTR&ncbi_uid=765257&link_uid=765257" title="View MedGen record for 'Hypogonadotropic hypogonadism 4 with or without anosmia'">Hypogonadotropic hypogonadism 4 with or without anosmia</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3552553[DISCUI]&test_type=Clinical" ref="ncbi_uid=765467">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=765467" target="_blank" href="/omim/612370">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/?term=(NBK1117%20OR%20NBK1334)%20AND%20gene%5Bbook%5D&showtype=onebook" ref="ncbi_uid=765467">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=765467" ref="ncbi_uid=765467">V</a></span></span><span class="TLline"><a href="/medgen/765467" ref="tree=GTR&ncbi_uid=765467&link_uid=765467" title="View MedGen record for 'Hypogonadotropic hypogonadism 5 with or without anosmia'">Hypogonadotropic hypogonadism 5 with or without anosmia</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3552574[DISCUI]&test_type=Clinical" ref="ncbi_uid=765488">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=765488" target="_blank" href="/omim/600483">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1334/" ref="ncbi_uid=765488">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=765488" ref="ncbi_uid=765488">V</a></span></span><span class="TLline"><a href="/medgen/765488" ref="tree=GTR&ncbi_uid=765488&link_uid=765488" title="View MedGen record for 'Hypogonadotropic hypogonadism 6 with or without anosmia'">Hypogonadotropic hypogonadism 6 with or without anosmia</a></span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/474891" ref="tree=MeSH" title="MedGen record for Congenital Systemic Disorder">Congenital Systemic Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/52948" ref="tree=MeSH" title="MedGen record for Abnormality of the genitourinary system">Abnormality of the genitourinary system</a></span><ul><li><span class="TLline"><a href="/medgen/769757" ref="tree=MeSH" title="MedGen record for Congenital Reproductive System Abnormality">Congenital Reproductive System Abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/415936" ref="tree=MeSH" title="MedGen record for Disorder of sexual differentiation">Disorder of sexual differentiation</a></span><ul><li><span class="TLline"><a href="/medgen/414114" ref="tree=MeSH" title="MedGen record for 46,XY disorder of sex development">46,XY disorder of sex development</a></span><ul><li><span class="TLline"><a href="/medgen/102469" ref="tree=MeSH" title="MedGen record for Hypogonadism with anosmia">Hypogonadism with anosmia</a></span><ul><li><span class="matched_ds">Hypogonadotropic hypogonadism 1 with or without anosmia</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37097352">Diagnosis and Management of Pituitary Adenomas: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tritos NA,
|
||
Miller KK</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2023 Apr 25;329(16):1386-1398.
|
||
doi: 10.1001/jama.2023.5444.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37097352" target="_blank">37097352</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32576618">Parkinson's disease: etiopathogenesis and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jankovic J,
|
||
Tan EK</span><br />
|
||
<span class="medgenPMjournal">J Neurol Neurosurg Psychiatry</span>
|
||
2020 Aug;91(8):795-808.
|
||
Epub 2020 Jun 23
|
||
doi: 10.1136/jnnp-2019-322338.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32576618" target="_blank">32576618</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31213699">Turner syndrome: mechanisms and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gravholt CH,
|
||
Viuff MH,
|
||
Brun S,
|
||
Stochholm K,
|
||
Andersen NH</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Endocrinol</span>
|
||
2019 Oct;15(10):601-614.
|
||
Epub 2019 Jun 18
|
||
doi: 10.1038/s41574-019-0224-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31213699" target="_blank">31213699</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(hypogonadotropic%20hypogonadism%201%20with%20or%20without%20anosmia)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (536)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38128110">Gonadotropins for pubertal induction in males with hypogonadotropic hypogonadism: systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Alexander EC,
|
||
Faruqi D,
|
||
Farquhar R,
|
||
Unadkat A,
|
||
Ng Yin K,
|
||
Hoskyns R,
|
||
Varughese R,
|
||
Howard SR</span><br />
|
||
<span class="medgenPMjournal">Eur J Endocrinol</span>
|
||
2024 Jan 3;190(1):S1-S11.
|
||
doi: 10.1093/ejendo/lvad166.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38128110" target="_blank">38128110</a><a href="/pmc/articles/PMC10773669" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37589949">Effect of Testosterone Replacement Therapy on Sexual Function and Hypogonadal Symptoms in Men with Hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pencina KM,
|
||
Travison TG,
|
||
Cunningham GR,
|
||
Lincoff AM,
|
||
Nissen SE,
|
||
Khera M,
|
||
Miller MG,
|
||
Flevaris P,
|
||
Li X,
|
||
Wannemuehler K,
|
||
Bhasin S</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2024 Jan 18;109(2):569-580.
|
||
doi: 10.1210/clinem/dgad484.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37589949" target="_blank">37589949</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33375030">Treatment of Men with Central Hypogonadism: Alternatives for Testosterone Replacement Therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ide V,
|
||
Vanderschueren D,
|
||
Antonio L</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2020 Dec 22;22(1)
|
||
doi: 10.3390/ijms22010021.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33375030" target="_blank">33375030</a><a href="/pmc/articles/PMC7792781" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31577259">Syndromic infertility.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Guerri G,
|
||
Maniscalchi T,
|
||
Barati S,
|
||
Dhuli K,
|
||
Busetto GM,
|
||
Del Giudice F,
|
||
De Berardinis E,
|
||
De Antoni L,
|
||
Miertus J,
|
||
Bertelli M</span><br />
|
||
<span class="medgenPMjournal">Acta Biomed</span>
|
||
2019 Sep 30;90(10-S):75-82.
|
||
doi: 10.23750/abm.v90i10-S.8764.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31577259" target="_blank">31577259</a><a href="/pmc/articles/PMC7233644" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31147553">Paediatric and adult-onset male hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Salonia A,
|
||
Rastrelli G,
|
||
Hackett G,
|
||
Seminara SB,
|
||
Huhtaniemi IT,
|
||
Rey RA,
|
||
Hellstrom WJG,
|
||
Palmert MR,
|
||
Corona G,
|
||
Dohle GR,
|
||
Khera M,
|
||
Chan YM,
|
||
Maggi M</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Dis Primers</span>
|
||
2019 May 30;5(1):38.
|
||
doi: 10.1038/s41572-019-0087-y.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31147553" target="_blank">31147553</a><a href="/pmc/articles/PMC6944317" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%201%20with%20or%20without%20anosmia%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4383)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35331309">Current clinical management of constitutional delay of growth and puberty.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gaudino R,
|
||
De Filippo G,
|
||
Bozzola E,
|
||
Gasparri M,
|
||
Bozzola M,
|
||
Villani A,
|
||
Radetti G</span><br />
|
||
<span class="medgenPMjournal">Ital J Pediatr</span>
|
||
2022 Mar 24;48(1):45.
|
||
doi: 10.1186/s13052-022-01242-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35331309" target="_blank">35331309</a><a href="/pmc/articles/PMC8944060" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35216725">Hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bhasin S,
|
||
Jayasena CN</span><br />
|
||
<span class="medgenPMjournal">Endocrinol Metab Clin North Am</span>
|
||
2022 Mar;51(1):xv-xvi.
|
||
Epub 2022 Feb 4
|
||
doi: 10.1016/j.ecl.2021.11.015.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35216725" target="_blank">35216725</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31577259">Syndromic infertility.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Guerri G,
|
||
Maniscalchi T,
|
||
Barati S,
|
||
Dhuli K,
|
||
Busetto GM,
|
||
Del Giudice F,
|
||
De Berardinis E,
|
||
De Antoni L,
|
||
Miertus J,
|
||
Bertelli M</span><br />
|
||
<span class="medgenPMjournal">Acta Biomed</span>
|
||
2019 Sep 30;90(10-S):75-82.
|
||
doi: 10.23750/abm.v90i10-S.8764.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31577259" target="_blank">31577259</a><a href="/pmc/articles/PMC7233644" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29382506">Klinefelter syndrome: more than hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kanakis GA,
|
||
Nieschlag E</span><br />
|
||
<span class="medgenPMjournal">Metabolism</span>
|
||
2018 Sep;86:135-144.
|
||
Epub 2018 Jan 31
|
||
doi: 10.1016/j.metabol.2017.09.017.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29382506" target="_blank">29382506</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23503957">Hypogonadotropic hypogonadism revisited.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fraietta R,
|
||
Zylberstejn DS,
|
||
Esteves SC</span><br />
|
||
<span class="medgenPMjournal">Clinics (Sao Paulo)</span>
|
||
2013;68 Suppl 1(Suppl 1):81-8.
|
||
doi: 10.6061/clinics/2013(sup01)09.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23503957" target="_blank">23503957</a><a href="/pmc/articles/PMC3583156" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%201%20with%20or%20without%20anosmia%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3736)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38231621">Testosterone Treatment and Fractures in Men with Hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Snyder PJ,
|
||
Bauer DC,
|
||
Ellenberg SS,
|
||
Cauley JA,
|
||
Buhr KA,
|
||
Bhasin S,
|
||
Miller MG,
|
||
Khan NS,
|
||
Li X,
|
||
Nissen SE</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2024 Jan 18;390(3):203-211.
|
||
doi: 10.1056/NEJMoa2308836.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38231621" target="_blank">38231621</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38229462">Testosterone replacement therapy: clinical considerations.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Luther PM,
|
||
Spillers NJ,
|
||
Talbot NC,
|
||
Sinnathamby ES,
|
||
Ellison D,
|
||
Kelkar RA,
|
||
Ahmadzadeh S,
|
||
Shekoohi S,
|
||
Kaye AD</span><br />
|
||
<span class="medgenPMjournal">Expert Opin Pharmacother</span>
|
||
2024 Jan-Apr;25(1):25-35.
|
||
Epub 2024 Feb 1
|
||
doi: 10.1080/14656566.2024.2306832.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38229462" target="_blank">38229462</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38128110">Gonadotropins for pubertal induction in males with hypogonadotropic hypogonadism: systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Alexander EC,
|
||
Faruqi D,
|
||
Farquhar R,
|
||
Unadkat A,
|
||
Ng Yin K,
|
||
Hoskyns R,
|
||
Varughese R,
|
||
Howard SR</span><br />
|
||
<span class="medgenPMjournal">Eur J Endocrinol</span>
|
||
2024 Jan 3;190(1):S1-S11.
|
||
doi: 10.1093/ejendo/lvad166.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38128110" target="_blank">38128110</a><a href="/pmc/articles/PMC10773669" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33375030">Treatment of Men with Central Hypogonadism: Alternatives for Testosterone Replacement Therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ide V,
|
||
Vanderschueren D,
|
||
Antonio L</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2020 Dec 22;22(1)
|
||
doi: 10.3390/ijms22010021.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33375030" target="_blank">33375030</a><a href="/pmc/articles/PMC7792781" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29382506">Klinefelter syndrome: more than hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kanakis GA,
|
||
Nieschlag E</span><br />
|
||
<span class="medgenPMjournal">Metabolism</span>
|
||
2018 Sep;86:135-144.
|
||
Epub 2018 Jan 31
|
||
doi: 10.1016/j.metabol.2017.09.017.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29382506" target="_blank">29382506</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%201%20with%20or%20without%20anosmia%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2886)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35874953">Revealing the mystery of persistent smell loss in Long COVID patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Park JW,
|
||
Wang X,
|
||
Xu RH</span><br />
|
||
<span class="medgenPMjournal">Int J Biol Sci</span>
|
||
2022;18(12):4795-4808.
|
||
Epub 2022 Jul 15
|
||
doi: 10.7150/ijbs.73485.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35874953" target="_blank">35874953</a><a href="/pmc/articles/PMC9305264" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34165581">Clinical Outcomes for Patients With Anosmia 1 Year After COVID-19 Diagnosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Renaud M,
|
||
Thibault C,
|
||
Le Normand F,
|
||
Mcdonald EG,
|
||
Gallix B,
|
||
Debry C,
|
||
Venkatasamy A</span><br />
|
||
<span class="medgenPMjournal">JAMA Netw Open</span>
|
||
2021 Jun 1;4(6):e2115352.
|
||
doi: 10.1001/jamanetworkopen.2021.15352.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34165581" target="_blank">34165581</a><a href="/pmc/articles/PMC8226421" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25041142">Testosterone and mortality.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Muraleedharan V,
|
||
Jones TH</span><br />
|
||
<span class="medgenPMjournal">Clin Endocrinol (Oxf)</span>
|
||
2014 Oct;81(4):477-87.
|
||
Epub 2014 Jul 7
|
||
doi: 10.1111/cen.12503.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25041142" target="_blank">25041142</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23643382">Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Miraoui H,
|
||
Dwyer AA,
|
||
Sykiotis GP,
|
||
Plummer L,
|
||
Chung W,
|
||
Feng B,
|
||
Beenken A,
|
||
Clarke J,
|
||
Pers TH,
|
||
Dworzynski P,
|
||
Keefe K,
|
||
Niedziela M,
|
||
Raivio T,
|
||
Crowley WF Jr,
|
||
Seminara SB,
|
||
Quinton R,
|
||
Hughes VA,
|
||
Kumanov P,
|
||
Young J,
|
||
Yialamas MA,
|
||
Hall JE,
|
||
Van Vliet G,
|
||
Chanoine JP,
|
||
Rubenstein J,
|
||
Mohammadi M,
|
||
Tsai PS,
|
||
Sidis Y,
|
||
Lage K,
|
||
Pitteloud N</span><br />
|
||
<span class="medgenPMjournal">Am J Hum Genet</span>
|
||
2013 May 2;92(5):725-43.
|
||
doi: 10.1016/j.ajhg.2013.04.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23643382" target="_blank">23643382</a><a href="/pmc/articles/PMC3644636" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9645824">Klinefelter syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Smyth CM,
|
||
Bremner WJ</span><br />
|
||
<span class="medgenPMjournal">Arch Intern Med</span>
|
||
1998 Jun 22;158(12):1309-14.
|
||
doi: 10.1001/archinte.158.12.1309.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9645824" target="_blank">9645824</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%201%20with%20or%20without%20anosmia%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1859)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38477512">Contributions of Common Genetic Variants to Constitutional Delay of Puberty and Idiopathic Hypogonadotropic Hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lippincott MF,
|
||
Schafer EC,
|
||
Hindman AA,
|
||
He W,
|
||
Brauner R,
|
||
Delaney A,
|
||
Grinspon R,
|
||
Hall JE,
|
||
Hirschhorn JN,
|
||
McElreavey K,
|
||
Palmert MR,
|
||
Rey R,
|
||
Seminara SB,
|
||
Salem RM,
|
||
Chan YM;
|
||
Delayed Puberty Genetics Consortium</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2024 Dec 18;110(1):e61-e67.
|
||
doi: 10.1210/clinem/dgae166.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38477512" target="_blank">38477512</a><a href="/pmc/articles/PMC11651688" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37589949">Effect of Testosterone Replacement Therapy on Sexual Function and Hypogonadal Symptoms in Men with Hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pencina KM,
|
||
Travison TG,
|
||
Cunningham GR,
|
||
Lincoff AM,
|
||
Nissen SE,
|
||
Khera M,
|
||
Miller MG,
|
||
Flevaris P,
|
||
Li X,
|
||
Wannemuehler K,
|
||
Bhasin S</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2024 Jan 18;109(2):569-580.
|
||
doi: 10.1210/clinem/dgad484.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37589949" target="_blank">37589949</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36507615">Use of platelet-rich plasma for COVID-19-related olfactory loss: a randomized controlled trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yan CH,
|
||
Jang SS,
|
||
Lin HC,
|
||
Ma Y,
|
||
Khanwalkar AR,
|
||
Thai A,
|
||
Patel ZM</span><br />
|
||
<span class="medgenPMjournal">Int Forum Allergy Rhinol</span>
|
||
2023 Jun;13(6):989-997.
|
||
Epub 2022 Dec 21
|
||
doi: 10.1002/alr.23116.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36507615" target="_blank">36507615</a><a href="/pmc/articles/PMC9877663" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29601923">Evaluation and Management of Testosterone Deficiency: AUA Guideline.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mulhall JP,
|
||
Trost LW,
|
||
Brannigan RE,
|
||
Kurtz EG,
|
||
Redmon JB,
|
||
Chiles KA,
|
||
Lightner DJ,
|
||
Miner MM,
|
||
Murad MH,
|
||
Nelson CJ,
|
||
Platz EA,
|
||
Ramanathan LV,
|
||
Lewis RW</span><br />
|
||
<span class="medgenPMjournal">J Urol</span>
|
||
2018 Aug;200(2):423-432.
|
||
Epub 2018 Mar 28
|
||
doi: 10.1016/j.juro.2018.03.115.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29601923" target="_blank">29601923</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23643382">Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Miraoui H,
|
||
Dwyer AA,
|
||
Sykiotis GP,
|
||
Plummer L,
|
||
Chung W,
|
||
Feng B,
|
||
Beenken A,
|
||
Clarke J,
|
||
Pers TH,
|
||
Dworzynski P,
|
||
Keefe K,
|
||
Niedziela M,
|
||
Raivio T,
|
||
Crowley WF Jr,
|
||
Seminara SB,
|
||
Quinton R,
|
||
Hughes VA,
|
||
Kumanov P,
|
||
Young J,
|
||
Yialamas MA,
|
||
Hall JE,
|
||
Van Vliet G,
|
||
Chanoine JP,
|
||
Rubenstein J,
|
||
Mohammadi M,
|
||
Tsai PS,
|
||
Sidis Y,
|
||
Lage K,
|
||
Pitteloud N</span><br />
|
||
<span class="medgenPMjournal">Am J Hum Genet</span>
|
||
2013 May 2;92(5):725-43.
|
||
doi: 10.1016/j.ajhg.2013.04.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23643382" target="_blank">23643382</a><a href="/pmc/articles/PMC3644636" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%201%20with%20or%20without%20anosmia%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3145)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/38128110">Gonadotropins for pubertal induction in males with hypogonadotropic hypogonadism: systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Alexander EC,
|
||
Faruqi D,
|
||
Farquhar R,
|
||
Unadkat A,
|
||
Ng Yin K,
|
||
Hoskyns R,
|
||
Varughese R,
|
||
Howard SR</span><br />
|
||
<span class="medgenPMjournal">Eur J Endocrinol</span>
|
||
2024 Jan 3;190(1):S1-S11.
|
||
doi: 10.1093/ejendo/lvad166.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38128110" target="_blank">38128110</a><a href="/pmc/articles/PMC10773669" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35146992">Impact of anabolic androgenic steroids on male sexual and reproductive function: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Esposito M,
|
||
Salerno M,
|
||
Calvano G,
|
||
Agliozzo R,
|
||
Ficarra V,
|
||
Sessa F,
|
||
Favilla V,
|
||
Cimino S,
|
||
Pomara C</span><br />
|
||
<span class="medgenPMjournal">Panminerva Med</span>
|
||
2023 Mar;65(1):43-50.
|
||
Epub 2022 Feb 11
|
||
doi: 10.23736/S0031-0808.22.04677-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35146992" target="_blank">35146992</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36013514">Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Leisegang K,
|
||
Finelli R,
|
||
Sikka SC,
|
||
Panner Selvam MK</span><br />
|
||
<span class="medgenPMjournal">Medicina (Kaunas)</span>
|
||
2022 Aug 4;58(8)
|
||
doi: 10.3390/medicina58081047.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36013514" target="_blank">36013514</a><a href="/pmc/articles/PMC9415500" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35739136">Long-COVID in children and adolescents: a systematic review and meta-analyses.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lopez-Leon S,
|
||
Wegman-Ostrosky T,
|
||
Ayuzo Del Valle NC,
|
||
Perelman C,
|
||
Sepulveda R,
|
||
Rebolledo PA,
|
||
Cuapio A,
|
||
Villapol S</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2022 Jun 23;12(1):9950.
|
||
doi: 10.1038/s41598-022-13495-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35739136" target="_blank">35739136</a><a href="/pmc/articles/PMC9226045" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34933414">Clomiphene citrate for men with hypogonadism: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Huijben M,
|
||
Lock MTWT,
|
||
de Kemp VF,
|
||
de Kort LMO,
|
||
van Breda HMK</span><br />
|
||
<span class="medgenPMjournal">Andrology</span>
|
||
2022 Mar;10(3):451-469.
|
||
Epub 2022 Jan 8
|
||
doi: 10.1111/andr.13146.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34933414" target="_blank">34933414</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%201%20with%20or%20without%20anosmia%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (211)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
|
||
<div class="rightCol mgCol">
|
||
<div class="portlet mgSection" id="ID_113">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul id="my-toc"></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_106">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C1563719%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (39)</a></li>
|
||
<li><a href="/gtr/tests?term=C1563719%5bDISCUI%5d&filter=method%3A2%5F29" target="_blank">Detection of homozygosity (2)</a></li>
|
||
<li><a href="/gtr/tests?term=C1563719%5bDISCUI%5d&filter=method%3A3%5F23" target="_blank">FISH-interphase (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C1563719%5bDISCUI%5d&filter=method%3A3%5F24" target="_blank">FISH-metaphase (9)</a></li>
|
||
<li><a href="/gtr/tests?term=C1563719%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C1563719%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (38)</a></li>
|
||
<li><a href="/gtr/tests?term=C1563719%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (13)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C1563719%5bDISCUI%5d" target="_blank">See all (57)</a></total></li>
|
||
</ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_119">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=308700" target="_blank">OMIM</a></li><li><a href="https://clinicaltrials.gov/search?cond=Hypogonadotropic%20hypogonadism%201%20with%20or%20without%20anosmia" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_121">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(hypogonadotropic%20hypogonadism%201%20with%20or%20without%20anosmia)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_115">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Molecular_resources">Molecular resources</h1><a sid="115" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=300836" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=3730[geneid]" target="_blank">View ANOS1 variations in ClinVar</a></li><li><a href="/nuccore/160358365" target="_blank">RefSeqGene</a></li><li><a href="https://catalog.coriell.org/Search?q=308700" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_116">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Consumer_resources">Consumer resources</h1><a sid="116" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="https://www.malacards.org/card/hypogonadotropic_hypogonadism_1_with_or_without_anosmia" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Hypogonadotropic%20hypogonadism%201%20with%20or%20without%20anosmia" target="_blank">MedlinePlus</a></li><li><a href="https://medlineplus.gov/genetics/condition/kallmann-syndrome" target="_blank">MedlinePlusGenetics (GHR)</a></li><li><a href="https://rarediseases.info.nih.gov/diseases/3071/disease" target="_blank">NCATS Office of Rare Diseases Research (GARD)</a></li></ul></div>
|
||
</div>
|
||
</div>
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Reviews</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Reviews" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="/pubmed/20301509" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=3" target="_blank"><span class="gene_reviews">GeneReviews</span></a>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/clinical?term=Hypogonadotropic%20hypogonadism%201%20with%20or%20without%20anosmia" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=3" target="_blank">PubMed Clinical Queries</a>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed?term=Hypogonadotropic%20hypogonadism%201%20with%20or%20without%20anosmia%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=3&linkpostotal=3" target="_blank">Reviews in PubMed</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<!-- MedGen supplemental column ends here -->
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content DiscoveryDbLinks">
|
||
<ul>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=295872" ref="log$=recordlinks">ClinVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gene?LinkName=medgen_gene_diseases&from_uid=295872" ref="log$=recordlinks">Gene</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in NCBI Gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C1563719[DISCUI]" ref="log$=recordlinks">GTR</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C1563719[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/mesh?LinkName=medgen_mesh&from_uid=295872" ref="log$=recordlinks">MeSH</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related Medical Subject Headings</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim&from_uid=295872" ref="log$=recordlinks">OMIM</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related records in OMIM</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim_gene&from_uid=295872" ref="log$=recordlinks">OMIM(Genes)</a>
|
||
<div class="brieflinkpop offscreen_noflow">OMIM records containing genes associated with phenotypes registered in MedGen</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=medgen_pmc&from_uid=295872" ref="log$=recordlinks">PMC Articles</a>
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