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1118 lines
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<meta name="keywords" content="C1560305, pathologic function, prolonged qtc interval, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A longer than normal interval (corrected for heart rate) between the Q and T waves in the heart's cycle. Prolonged QTc can cause premature action potentials during late phase depolarizations thereby leading to ventricular arrhythmias and ventricular fibrillations." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=294666
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ConceptID=C1560305
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Prolonged QTc interval</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>294666</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1560305</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pathologic Function</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>HPO:</td>
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0005184">HP:0005184</a></td></tr>
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<div class="portlet_content ln">A longer than normal interval (corrected for heart rate) between the Q and T waves in the heart's cycle. Prolonged QTc can cause premature action potentials during late phase depolarizations thereby leading to ventricular arrhythmias and ventricular fibrillations. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Prolonged QTc interval</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/1715859" ref="tree=MeSH" title="MedGen record for Abnormal Cardiac Study">Abnormal Cardiac Study</a></span><ul><li><span class="TLline"><a href="/medgen/105507" ref="tree=MeSH" title="MedGen record for Abnormal EKG">Abnormal EKG</a></span><ul><li><span class="TLline"><a href="/medgen/1620328" ref="tree=MeSH" title="MedGen record for Abnormal QT interval">Abnormal QT interval</a></span><ul><li><span class="TLline"><a href="/medgen/57494" ref="tree=MeSH" title="MedGen record for Prolonged QT interval">Prolonged QT interval</a></span><ul><li><span class="matched_ds">Prolonged QTc interval</span></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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||
<div class="divPopper rprt" id="rdis_48441"><div><strong>Rett syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>48441</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0035372</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The spectrum of MECP2-related phenotypes in females ranges from classic Rett syndrome to variant Rett syndrome with a broader clinical phenotype (either milder or more severe than classic Rett syndrome) to mild learning disabilities; the spectrum in males ranges from severe neonatal encephalopathy to pyramidal signs, parkinsonism, and macroorchidism (PPM-X) syndrome to severe syndromic/nonsyndromic intellectual disability. Females: Classic Rett syndrome, a progressive neurodevelopmental disorder primarily affecting girls, is characterized by apparently normal psychomotor development during the first six to 18 months of life, followed by a short period of developmental stagnation, then rapid regression in language and motor skills, followed by long-term stability. During the phase of rapid regression, repetitive, stereotypic hand movements replace purposeful hand use. Additional findings include fits of screaming and inconsolable crying, autistic features, panic-like attacks, bruxism, episodic apnea and/or hyperpnea, gait ataxia and apraxia, tremors, seizures, and acquired microcephaly. Males: Severe neonatal-onset encephalopathy, the most common phenotype in affected males, is characterized by a relentless clinical course that follows a metabolic-degenerative type of pattern, abnormal tone, involuntary movements, severe seizures, and breathing abnormalities. Death often occurs before age two years.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/48441">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_327586"><div><strong>Andersen Tawil syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>327586</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1563715</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Andersen-Tawil syndrome (ATS) is characterized by a triad of: episodic flaccid muscle weakness (i.e., periodic paralysis); ventricular arrhythmias and prolonged QT interval; and anomalies including low-set ears, widely spaced eyes, small mandible, fifth-digit clinodactyly, syndactyly, short stature, and scoliosis. Affected individuals present in the first or second decade with either cardiac symptoms (palpitations and/or syncope) or weakness that occurs spontaneously following prolonged rest or following rest after exertion. Mild permanent weakness is common. Mild learning difficulties and a distinct neurocognitive phenotype (i.e., deficits in executive function and abstract reasoning) have been described.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/327586">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_331395"><div><strong>Timothy syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>331395</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1832916</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The clinical manifestations of CACNA1C-related disorders include a spectrum of nonsyndromic and syndromic phenotypes, which generally correlate with the impact of the pathogenic variant on calcium current. Phenotypes can include nonsyndromic long QT syndrome (rate-corrected QT [QTc] interval >480 ms); nonsyndromic short QT syndrome (QTc <350 ms), with risk of sudden death; Brugada syndrome (ST segment elevation in right precordial leads [V1-V2]) with short QT interval; classic Timothy syndrome (prolonged QT interval, autism, and congenital heart defect) with or without unilateral or bilateral cutaneous syndactyly variably involving fingers two (index), three (middle), four (ring), and five (little) and bilateral cutaneous syndactyly of toes two and three; and CACNA1C-related neurodevelopmental disorder, in which the features tend to favor one or more of the following: developmental delay / intellectual disability, hypotonia, epilepsy, and/or ataxia.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/331395">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_320273"><div><strong>Sick sinus syndrome 2, autosomal dominant</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>320273</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1834144</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Sick sinus syndrome (also known as sinus node dysfunction) is a group of related heart conditions that can affect how the heart beats. "Sick sinus" refers to the sino-atrial (SA) node, which is an area of specialized cells in the heart that functions as a natural pacemaker. The SA node generates electrical impulses that start each heartbeat. These signals travel from the SA node to the rest of the heart, signaling the heart (cardiac) muscle to contract and pump blood. In people with sick sinus syndrome, the SA node does not function normally. In some cases, it does not produce the right signals to trigger a regular heartbeat. In others, abnormalities disrupt the electrical impulses and prevent them from reaching the rest of the heart.\n\nSick sinus syndrome tends to cause the heartbeat to be too slow (bradycardia), although occasionally the heartbeat is too fast (tachycardia). In some cases, the heartbeat rapidly switches from being too fast to being too slow, a condition known as tachycardia-bradycardia syndrome. Symptoms related to abnormal heartbeats can include dizziness, light-headedness, fainting (syncope), a sensation of fluttering or pounding in the chest (palpitations), and confusion or memory problems. During exercise, many affected individuals experience chest pain, difficulty breathing, or excessive tiredness (fatigue). Once symptoms of sick sinus syndrome appear, they usually worsen with time. However, some people with the condition never experience any related health problems.\n\nSick sinus syndrome occurs most commonly in older adults, although it can be diagnosed in people of any age. The condition increases the risk of several life-threatening problems involving the heart and blood vessels. These include a heart rhythm abnormality called atrial fibrillation, heart failure, cardiac arrest, and stroke.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/320273">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_373232"><div><strong>Atrial fibrillation, familial, 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>373232</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1837014</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Atrial fibrillation (AF) is the most common sustained cardiac rhythm disturbance, affecting more than 2 million Americans, with an overall prevalence of 0.89%. The prevalence increases rapidly with age, to 2.3% between the ages of 40 and 60 years, and to 5.9% over the age of 65. The most dreaded complication is thromboembolic stroke (Brugada et al., 1997). For a discussion of genetic heterogeneity of atrial fibrillation, see 608583.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/373232">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_349087"><div><strong>Long QT syndrome 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>349087</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1859062</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Congenital long QT syndrome is electrocardiographically characterized by a prolonged QT interval and polymorphic ventricular arrhythmias (torsade de pointes). These cardiac arrhythmias may result in recurrent syncope, seizure, or sudden death (Jongbloed et al., 1999). For a discussion of genetic heterogeneity of long QT syndrome, see LQT1 (192500).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/349087">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_358092"><div><strong>Long QT syndrome 5</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>358092</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1867904</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Congenital long QT syndrome is electrocardiographically characterized by a prolonged QT interval and polymorphic ventricular arrhythmias (torsade de pointes). These cardiac arrhythmias may result in recurrent syncope, seizure, or sudden death (Jongbloed et al., 1999). For a discussion of genetic heterogeneity of long QT syndrome, see LQT1 (192500).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/358092">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_393658"><div><strong>Atrial fibrillation, familial, 7</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>393658</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2677106</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Atrial fibrillation (AF) is the most common sustained cardiac rhythm disturbance, affecting more than 2 million Americans, with an overall prevalence of 0.89%. The prevalence increases rapidly with age, to 2.3% between the ages of 40 and 60 years, and to 5.9% over the age of 65. The most dreaded complication is thromboembolic stroke (Brugada et al., 1997). For a discussion of genetic heterogeneity of atrial fibrillation, see 608583.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/393658">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_437218"><div><strong>Long QT syndrome 11</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>437218</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2678483</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Congenital long QT syndrome is electrocardiographically characterized by a prolonged QT interval and polymorphic ventricular arrhythmias (torsade de pointes). These cardiac arrhythmias may result in recurrent syncope, seizure, or sudden death (Jongbloed et al., 1999).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/437218">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_442824"><div><strong>Long QT syndrome 12</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>442824</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2751830</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Congenital long QT syndrome (LQTS) is electrocardiographically characterized by a prolonged QT interval and polymorphic ventricular arrhythmias (torsade de pointes). These cardiac arrhythmias may result in recurrent syncope, seizure, or sudden death (Jongbloed et al., 1999). For a discussion of genetic heterogeneity of long QT syndrome, see LQT1 (192500).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/442824">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_462083"><div><strong>Long QT syndrome 13</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462083</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C3150733</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Congenital long QT syndrome is electrocardiographically characterized by a prolonged QT interval and polymorphic ventricular arrhythmias (torsade de pointes). These cardiac arrhythmias may result in recurrent syncope, seizure, or sudden death (Jongbloed et al., 1999). For a discussion of genetic heterogeneity of long QT syndrome, see LQT1 (192500).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462083">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_462293"><div><strong>Long QT syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462293</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3150943</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Congenital long QT syndrome is electrocardiographically characterized by a prolonged QT interval and polymorphic ventricular arrhythmias (torsade de pointes). These cardiac arrhythmias may result in recurrent syncope, seizure, or sudden death (Jongbloed et al., 1999). For a discussion of genetic heterogeneity of long QT syndrome, see LQT1 (192500).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462293">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_462303"><div><strong>Long QT syndrome 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462303</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3150953</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Congenital long QT syndrome is electrocardiographically characterized by a prolonged QT interval and polymorphic ventricular arrhythmias (torsade de pointes). These cardiac arrhythmias may result in recurrent syncope, seizure, or sudden death (Jongbloed et al., 1999). For a discussion of genetic heterogeneity of long QT syndrome, see LQT1 (192500).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462303">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_462781"><div><strong>Atrial fibrillation, familial, 9</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462781</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3151431</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Atrial fibrillation (AF) is the most common sustained cardiac rhythm disturbance, affecting more than 2 million Americans, with an overall prevalence of 0.89%. The prevalence increases rapidly with age, to 2.3% between the ages of 40 and 60 years, and to 5.9% over the age of 65. The most dreaded complication is thromboembolic stroke (Brugada et al., 1997). For a discussion of genetic heterogeneity of atrial fibrillation, see 608583.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462781">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_462813"><div><strong>Catecholaminergic polymorphic ventricular tachycardia 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462813</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3151463</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Catecholaminergic polymorphic ventricular tachycardia (CPVT) is characterized by episodic syncope occurring during exercise or acute emotion. The underlying cause of these episodes is the onset of fast ventricular tachycardia (bidirectional or polymorphic). Spontaneous recovery may occur when these arrhythmias self-terminate. In other instances, ventricular tachycardia may degenerate into ventricular fibrillation and cause sudden death if cardiopulmonary resuscitation is not readily available. The mean onset of symptoms (usually a syncopal episode) is between age seven and 12 years; onset as late as the fourth decade of life has been reported. If untreated, CPVT is highly lethal, as approximately 30% of affected individuals experience at least one cardiac arrest and up to 80% have one or more syncopal spells. Sudden death may be the first manifestation of the disease.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462813">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_863722"><div><strong>Atrial conduction disease</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>863722</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4015285</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A rare genetic cardiac disease characterized by variably expressed atrial tachyarrhythmia (such as atrial flutter, paroxysmal or chronic atrial fibrillation, ectopic atrial tachycardia, or multifocal atrial tachycardia), infra-Hisian conduction system disease, and vulnerability to dilated cardiomyopathy. Age of onset ranges between childhood and adulthood.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/863722">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_864108"><div><strong>Long QT syndrome 14</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>864108</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4015671</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">LQT14 is a cardiac arrhythmia disorder characterized by ventricular arrhythmias, often life-threatening, occurring very early in life, frequent episodes of T-wave alternans, markedly prolonged QTc intervals, and intermittent 2:1 atrioventricular block (Crotti et al., 2013). Patients with LQT14, LQT15 (616249), or LQT16 (618782), resulting from mutation in calmodulin genes CALM1, CALM2 (114182), or CALM3 (114183), respectively, typically have a more severe phenotype, with earlier onset, profound QT prolongation, and a high predilection for cardiac arrest and sudden death, than patients with mutations in other genes (Boczek et al., 2016).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/864108">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_864132"><div><strong>Long QT syndrome 15</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>864132</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4015695</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">LQT15 is a cardiac arrhythmia disorder characterized by ventricular arrhythmias, often life-threatening, occurring very early in life, frequent episodes of T-wave alternans, markedly prolonged QTc intervals, and intermittent 2:1 atrioventricular block (Crotti et al., 2013). Patients with LQT14 (616247), LQT15, or LQT16 (618782), resulting from mutation in calmodulin genes CALM1 (114180), CALM2, or CALM3 (114183), respectively, typically have a more severe phenotype, with earlier onset, profound QT prolongation, and a high predilection for cardiac arrest and sudden death, than patients with mutations in other genes (Boczek et al., 2016).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/864132">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_934716"><div><strong>Hypertrophic cardiomyopathy 26</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>934716</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4310749</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial cardiomyopathy caused by mutation in the FLNC gene has been described as hypertrophic, restrictive, dilated, or arrhythmogenic right ventricular cardiomyopathy. Affected individuals, especially those with dilated cardiomyopathy, are at risk for arrhythmias and sudden death. Arrhythmias without cardiomyopathy, and left ventricular noncompaction, have also been reported (Ortiz-Genga et al., 2016; Verdonschot et al., 2020).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/934716">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1646925"><div><strong>Jervell and Lange-Nielsen syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1646925</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4551509</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Jervell and Lange-Nielsen syndrome (JLNS) is characterized by congenital profound bilateral sensorineural hearing loss and long QTc, usually >500 msec. Prolongation of the QTc interval is associated with tachyarrhythmias, including ventricular tachycardia, episodes of torsade de pointes ventricular tachycardia, and ventricular fibrillation, which may culminate in syncope or sudden death. Iron-deficient anemia and elevated levels of gastrin are also frequent features of JLNS. The classic presentation of JLNS is a deaf child who experiences syncopal episodes during periods of stress, exercise, or fright. Fifty percent of individuals with JLNS had cardiac events before age three years. More than half of untreated children with JLNS die before age 15 years.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1646925">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1641146"><div><strong>Long QT syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1641146</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4551647</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">An autosomal dominant condition caused by mutation(s) in the KCNQ1 gene, encoding potassium voltage-gated channel subfamily KQT member 1. It is characterized by a prolonged QT interval that may result in torsade de pointes, ventricular fibrillation and/or sudden cardiac death.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1641146">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1713991"><div><strong>Long QT syndrome 16</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1713991</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5394068</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">LQT16 Long QT syndrome-16 (LQT16) is characterized by a markedly prolonged corrected QT (QTc) interval and 2:1 atrioventricular (AV) block, with onset in the perinatal period. Patients experience bradycardia or ventricular tachyarrhythmias that may result in syncope, cardiac arrest, and/or sudden death (Reed et al., 2015; Wren et al., 2019). Patients with LQT14 (616247), LQT15 (616249), or LQT16, resulting from mutation in calmodulin genes CALM1 (114180), CALM2 (114182), or CALM3, respectively, typically have a more severe phenotype, with earlier onset, profound QT prolongation, and a high predilection for cardiac arrest and sudden death, than patients with mutations in other genes (Boczek et al., 2016). CPVT6 Catecholaminergic polymorphic ventricular tachycardia-6 (CPVT6) is characterized by childhood-onset syncopal episodes with exercise or stress. Electrocardiogram (ECG) shows a normal QT interval with a prominent U wave, and stress testing reveals premature ventricular contractions (PVCs) that may occur as bigeminy or couplets, and nonsustained ventricular tachycardia (Gomez-Hurtado et al., 2016).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1713991">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1769385"><div><strong>Myofibrillar myopathy 10</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1769385</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5436656</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Myofibrillar myopathy-10 (MFM10) is an autosomal recessive structural muscle disorder characterized by onset of muscle pain, cramping, and exercise fatigue in the first or second decades of life. Some patients have mild contractures of the large joints apparent in early childhood. Affected individuals have a characteristic appearance of a thick neck and prominent shoulder girdle with anteverted shoulders and a tendency toward kyphosis. There is no apparent muscle weakness, but some affected individuals show progressive muscle rigidity leading to limited mobility. There is variable cardiac involvement, ranging from chest pain with left ventricular hypertrophy to subclinical signs such as abnormal EKG or elevated cardiac enzymes. Skeletal muscle biopsy shows structural abnormalities with myofibrillar disorganization and accumulation of autophagocytic vacuoles (summary by Hedberg-Oldfors et al., 2020). For a general phenotypic description and a discussion of genetic heterogeneity of myofibrillar myopathy, see MFM1 (601419).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1769385">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1798947"><div><strong>Recurrent metabolic encephalomyopathic crises-rhabdomyolysis-cardiac arrhythmia-intellectual disability syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1798947</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5567524</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">TANGO2 deficiency is characterized by developmental delay, intellectual disability, gait incoordination, speech difficulties, seizures, and hypothyroidism. Most individuals have TANGO2 spells, non-life-threatening paroxysmal worsening of baseline symptoms, including sudden onset of hypotonia, ataxia with loss of balance, head and body tilt, increased dysarthria, drooling, lethargy, and disorientation. In addition, life-threatening acute metabolic crises can occur, including rhabdomyolysis with elevated creatine phosphokinase and liver transaminases, hypoglycemia, prolonged QTc on EKG, ventricular arrhythmias, and/or cardiomyopathy.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1798947">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_327586" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Andersen Tawil syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_863722" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Atrial conduction disease</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_373232" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Atrial fibrillation, familial, 3</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_393658" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Atrial fibrillation, familial, 7</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462781" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Atrial fibrillation, familial, 9</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (24)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462813" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Catecholaminergic polymorphic ventricular tachycardia 3</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_934716" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypertrophic cardiomyopathy 26</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1646925" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Jervell and Lange-Nielsen syndrome 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1641146" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Long QT syndrome 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_437218" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Long QT syndrome 11</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_442824" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Long QT syndrome 12</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462083" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Long QT syndrome 13</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_864108" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Long QT syndrome 14</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_864132" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Long QT syndrome 15</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1713991" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Long QT syndrome 16</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462293" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Long QT syndrome 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_349087" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Long QT syndrome 3</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_358092" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Long QT syndrome 5</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462303" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Long QT syndrome 6</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1769385" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Myofibrillar myopathy 10</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1798947" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Recurrent metabolic encephalomyopathic crises-rhabdomyolysis-cardiac arrhythmia-intellectual disability syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_48441" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Rett syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_320273" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Sick sinus syndrome 2, autosomal dominant</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_331395" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Timothy syndrome</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/31112702">Risk assessment of energy drinks with focus on cardiovascular parameters and energy drink consumption in Europe.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ehlers A,
|
||
Marakis G,
|
||
Lampen A,
|
||
Hirsch-Ernst KI</span><br />
|
||
<span class="medgenPMjournal">Food Chem Toxicol</span>
|
||
2019 Aug;130:109-121.
|
||
Epub 2019 May 18
|
||
doi: 10.1016/j.fct.2019.05.028.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31112702" target="_blank">31112702</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25226194">Management of psychosis and agitation in medical-surgical patients who have or are at risk for prolonged QT interval.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ries R,
|
||
Sayadipour A</span><br />
|
||
<span class="medgenPMjournal">J Psychiatr Pract</span>
|
||
2014 Sep;20(5):338-44.
|
||
doi: 10.1097/01.pra.0000454778.29433.7c.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25226194" target="_blank">25226194</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11347723">A risk-benefit assessment of levofloxacin in respiratory, skin and skin structure, and urinary tract infections.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Martin SJ,
|
||
Jung R,
|
||
Garvin CG</span><br />
|
||
<span class="medgenPMjournal">Drug Saf</span>
|
||
2001;24(3):199-222.
|
||
doi: 10.2165/00002018-200124030-00004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11347723" target="_blank">11347723</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22prolonged%20qtc%20interval%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (16)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38506880">Electrocardiographic Findings in Female Professional Basketball Athletes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lander BS,
|
||
Duffy EY,
|
||
Hennessey JA,
|
||
Tolani S,
|
||
Patel N,
|
||
Bohnen MS,
|
||
Hsu JJ,
|
||
Danielian A,
|
||
Shah AB,
|
||
Goolsby M,
|
||
Martinez MW,
|
||
Phelan D,
|
||
Engel DJ</span><br />
|
||
<span class="medgenPMjournal">JAMA Cardiol</span>
|
||
2024 May 1;9(5):475-479.
|
||
doi: 10.1001/jamacardio.2024.0207.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38506880" target="_blank">38506880</a><a href="/pmc/articles/PMC10955342" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35864808">Prolonged QT Interval in Cirrhosis: Twisting Time?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee W,
|
||
Vandenberk B,
|
||
Raj SR,
|
||
Lee SS</span><br />
|
||
<span class="medgenPMjournal">Gut Liver</span>
|
||
2022 Nov 15;16(6):849-860.
|
||
Epub 2022 Jul 22
|
||
doi: 10.5009/gnl210537.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35864808" target="_blank">35864808</a><a href="/pmc/articles/PMC9668500" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29663451">Association of prolonged QTc interval with Takotsubo cardiomyopathy: A neurocardiac syndrome inside the mystery of the insula of Reil.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Marafioti V,
|
||
Turri G,
|
||
Carbone V,
|
||
Monaco S</span><br />
|
||
<span class="medgenPMjournal">Clin Cardiol</span>
|
||
2018 Apr;41(4):551-555.
|
||
Epub 2018 Apr 17
|
||
doi: 10.1002/clc.22910.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29663451" target="_blank">29663451</a><a href="/pmc/articles/PMC6490097" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28012118">Risk factors for QTc-prolongation: systematic review of the evidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vandael E,
|
||
Vandenberk B,
|
||
Vandenberghe J,
|
||
Willems R,
|
||
Foulon V</span><br />
|
||
<span class="medgenPMjournal">Int J Clin Pharm</span>
|
||
2017 Feb;39(1):16-25.
|
||
Epub 2016 Dec 23
|
||
doi: 10.1007/s11096-016-0414-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28012118" target="_blank">28012118</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21550581">Clinical significance of prolonged QTc interval in Williams syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Collins RT 2nd</span><br />
|
||
<span class="medgenPMjournal">Am J Cardiol</span>
|
||
2011 Aug 1;108(3):471-3.
|
||
Epub 2011 May 6
|
||
doi: 10.1016/j.amjcard.2011.03.071.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21550581" target="_blank">21550581</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Prolonged%20QTc%20interval%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (314)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34857877">QTc intervals are not prolonged in former ELBW infants at pre-adolescent age.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Salaets T,
|
||
Raaijmakers A,
|
||
Zhang ZY,
|
||
Yu YL,
|
||
Wei DM,
|
||
Staessen JA,
|
||
Allegaert K</span><br />
|
||
<span class="medgenPMjournal">Pediatr Res</span>
|
||
2022 Sep;92(3):848-852.
|
||
Epub 2021 Dec 2
|
||
doi: 10.1038/s41390-021-01877-w.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34857877" target="_blank">34857877</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29380395">Prolonged corrected QT interval in predicting atrial fibrillation: A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang N,
|
||
Gong M,
|
||
Tse G,
|
||
Zhang Z,
|
||
Meng L,
|
||
Yan BP,
|
||
Zhang L,
|
||
Wu G,
|
||
Xia Y,
|
||
Xin-Yan G,
|
||
Li G,
|
||
Liu T</span><br />
|
||
<span class="medgenPMjournal">Pacing Clin Electrophysiol</span>
|
||
2018 Mar;41(3):321-327.
|
||
Epub 2018 Feb 16
|
||
doi: 10.1111/pace.13292.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29380395" target="_blank">29380395</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28012118">Risk factors for QTc-prolongation: systematic review of the evidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vandael E,
|
||
Vandenberk B,
|
||
Vandenberghe J,
|
||
Willems R,
|
||
Foulon V</span><br />
|
||
<span class="medgenPMjournal">Int J Clin Pharm</span>
|
||
2017 Feb;39(1):16-25.
|
||
Epub 2016 Dec 23
|
||
doi: 10.1007/s11096-016-0414-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28012118" target="_blank">28012118</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23398819">Barth syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Clarke SL,
|
||
Bowron A,
|
||
Gonzalez IL,
|
||
Groves SJ,
|
||
Newbury-Ecob R,
|
||
Clayton N,
|
||
Martin RP,
|
||
Tsai-Goodman B,
|
||
Garratt V,
|
||
Ashworth M,
|
||
Bowen VM,
|
||
McCurdy KR,
|
||
Damin MK,
|
||
Spencer CT,
|
||
Toth MJ,
|
||
Kelley RI,
|
||
Steward CG</span><br />
|
||
<span class="medgenPMjournal">Orphanet J Rare Dis</span>
|
||
2013 Feb 12;8:23.
|
||
doi: 10.1186/1750-1172-8-23.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23398819" target="_blank">23398819</a><a href="/pmc/articles/PMC3583704" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21550581">Clinical significance of prolonged QTc interval in Williams syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Collins RT 2nd</span><br />
|
||
<span class="medgenPMjournal">Am J Cardiol</span>
|
||
2011 Aug 1;108(3):471-3.
|
||
Epub 2011 May 6
|
||
doi: 10.1016/j.amjcard.2011.03.071.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21550581" target="_blank">21550581</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Prolonged%20QTc%20interval%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (182)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37534722">QTc prolongation in patients with schizophrenia taking antipsychotics: Prevalence and risk factors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Du W,
|
||
Ge MW,
|
||
Hu FH,
|
||
Jia YJ,
|
||
Zhao DY,
|
||
Cheng YJ,
|
||
Chen HL</span><br />
|
||
<span class="medgenPMjournal">J Psychopharmacol</span>
|
||
2023 Oct;37(10):971-981.
|
||
Epub 2023 Aug 3
|
||
doi: 10.1177/02698811231190864.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37534722" target="_blank">37534722</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34857877">QTc intervals are not prolonged in former ELBW infants at pre-adolescent age.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Salaets T,
|
||
Raaijmakers A,
|
||
Zhang ZY,
|
||
Yu YL,
|
||
Wei DM,
|
||
Staessen JA,
|
||
Allegaert K</span><br />
|
||
<span class="medgenPMjournal">Pediatr Res</span>
|
||
2022 Sep;92(3):848-852.
|
||
Epub 2021 Dec 2
|
||
doi: 10.1038/s41390-021-01877-w.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34857877" target="_blank">34857877</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28012118">Risk factors for QTc-prolongation: systematic review of the evidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vandael E,
|
||
Vandenberk B,
|
||
Vandenberghe J,
|
||
Willems R,
|
||
Foulon V</span><br />
|
||
<span class="medgenPMjournal">Int J Clin Pharm</span>
|
||
2017 Feb;39(1):16-25.
|
||
Epub 2016 Dec 23
|
||
doi: 10.1007/s11096-016-0414-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28012118" target="_blank">28012118</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25641929">Extreme doses of intravenous methadone for severe pain in two children with cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rasmussen VF,
|
||
Lundberg V,
|
||
Jespersen TW,
|
||
Hasle H</span><br />
|
||
<span class="medgenPMjournal">Pediatr Blood Cancer</span>
|
||
2015 Jun;62(6):1087-90.
|
||
Epub 2015 Jan 13
|
||
doi: 10.1002/pbc.25392.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25641929" target="_blank">25641929</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21550581">Clinical significance of prolonged QTc interval in Williams syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Collins RT 2nd</span><br />
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<span class="medgenPMjournal">Am J Cardiol</span>
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2011 Aug 1;108(3):471-3.
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Epub 2011 May 6
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doi: 10.1016/j.amjcard.2011.03.071.
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<span class="bold">PMID: </span><a href="/pubmed/21550581" target="_blank">21550581</a></div>
|
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Prolonged%20QTc%20interval%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (204)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35864808">Prolonged QT Interval in Cirrhosis: Twisting Time?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee W,
|
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Vandenberk B,
|
||
Raj SR,
|
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Lee SS</span><br />
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<span class="medgenPMjournal">Gut Liver</span>
|
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2022 Nov 15;16(6):849-860.
|
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Epub 2022 Jul 22
|
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doi: 10.5009/gnl210537.
|
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<span class="bold">PMID: </span><a href="/pubmed/35864808" target="_blank">35864808</a><a href="/pmc/articles/PMC9668500" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34857877">QTc intervals are not prolonged in former ELBW infants at pre-adolescent age.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Salaets T,
|
||
Raaijmakers A,
|
||
Zhang ZY,
|
||
Yu YL,
|
||
Wei DM,
|
||
Staessen JA,
|
||
Allegaert K</span><br />
|
||
<span class="medgenPMjournal">Pediatr Res</span>
|
||
2022 Sep;92(3):848-852.
|
||
Epub 2021 Dec 2
|
||
doi: 10.1038/s41390-021-01877-w.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34857877" target="_blank">34857877</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33183070">Epicardial adipose tissue predicted prolonged QTc interval in patients with arterial hypertension.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yılmaz AS,
|
||
Çinier G,
|
||
Çırakoğlu ÖF,
|
||
Çetin M</span><br />
|
||
<span class="medgenPMjournal">Clin Exp Hypertens</span>
|
||
2021 Apr 3;43(3):230-236.
|
||
Epub 2020 Nov 12
|
||
doi: 10.1080/10641963.2020.1847131.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33183070" target="_blank">33183070</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29663451">Association of prolonged QTc interval with Takotsubo cardiomyopathy: A neurocardiac syndrome inside the mystery of the insula of Reil.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Marafioti V,
|
||
Turri G,
|
||
Carbone V,
|
||
Monaco S</span><br />
|
||
<span class="medgenPMjournal">Clin Cardiol</span>
|
||
2018 Apr;41(4):551-555.
|
||
Epub 2018 Apr 17
|
||
doi: 10.1002/clc.22910.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29663451" target="_blank">29663451</a><a href="/pmc/articles/PMC6490097" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29380395">Prolonged corrected QT interval in predicting atrial fibrillation: A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang N,
|
||
Gong M,
|
||
Tse G,
|
||
Zhang Z,
|
||
Meng L,
|
||
Yan BP,
|
||
Zhang L,
|
||
Wu G,
|
||
Xia Y,
|
||
Xin-Yan G,
|
||
Li G,
|
||
Liu T</span><br />
|
||
<span class="medgenPMjournal">Pacing Clin Electrophysiol</span>
|
||
2018 Mar;41(3):321-327.
|
||
Epub 2018 Feb 16
|
||
doi: 10.1111/pace.13292.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29380395" target="_blank">29380395</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Prolonged%20QTc%20interval%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (166)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34857877">QTc intervals are not prolonged in former ELBW infants at pre-adolescent age.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Salaets T,
|
||
Raaijmakers A,
|
||
Zhang ZY,
|
||
Yu YL,
|
||
Wei DM,
|
||
Staessen JA,
|
||
Allegaert K</span><br />
|
||
<span class="medgenPMjournal">Pediatr Res</span>
|
||
2022 Sep;92(3):848-852.
|
||
Epub 2021 Dec 2
|
||
doi: 10.1038/s41390-021-01877-w.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34857877" target="_blank">34857877</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29663451">Association of prolonged QTc interval with Takotsubo cardiomyopathy: A neurocardiac syndrome inside the mystery of the insula of Reil.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Marafioti V,
|
||
Turri G,
|
||
Carbone V,
|
||
Monaco S</span><br />
|
||
<span class="medgenPMjournal">Clin Cardiol</span>
|
||
2018 Apr;41(4):551-555.
|
||
Epub 2018 Apr 17
|
||
doi: 10.1002/clc.22910.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29663451" target="_blank">29663451</a><a href="/pmc/articles/PMC6490097" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29380395">Prolonged corrected QT interval in predicting atrial fibrillation: A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang N,
|
||
Gong M,
|
||
Tse G,
|
||
Zhang Z,
|
||
Meng L,
|
||
Yan BP,
|
||
Zhang L,
|
||
Wu G,
|
||
Xia Y,
|
||
Xin-Yan G,
|
||
Li G,
|
||
Liu T</span><br />
|
||
<span class="medgenPMjournal">Pacing Clin Electrophysiol</span>
|
||
2018 Mar;41(3):321-327.
|
||
Epub 2018 Feb 16
|
||
doi: 10.1111/pace.13292.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29380395" target="_blank">29380395</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28012118">Risk factors for QTc-prolongation: systematic review of the evidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vandael E,
|
||
Vandenberk B,
|
||
Vandenberghe J,
|
||
Willems R,
|
||
Foulon V</span><br />
|
||
<span class="medgenPMjournal">Int J Clin Pharm</span>
|
||
2017 Feb;39(1):16-25.
|
||
Epub 2016 Dec 23
|
||
doi: 10.1007/s11096-016-0414-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28012118" target="_blank">28012118</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25641929">Extreme doses of intravenous methadone for severe pain in two children with cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rasmussen VF,
|
||
Lundberg V,
|
||
Jespersen TW,
|
||
Hasle H</span><br />
|
||
<span class="medgenPMjournal">Pediatr Blood Cancer</span>
|
||
2015 Jun;62(6):1087-90.
|
||
Epub 2015 Jan 13
|
||
doi: 10.1002/pbc.25392.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25641929" target="_blank">25641929</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Prolonged%20QTc%20interval%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (213)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/38922589">Hydroxychloroquine and Chloroquine-Induced Cardiac Arrhythmias and Sudden Cardiac Death in Patients With Systemic Autoimmune Rheumatic Diseases: A Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nikolic RPA,
|
||
Virk MK,
|
||
Buhler KA,
|
||
Costenbader KH,
|
||
Choi MY,
|
||
Weber BN</span><br />
|
||
<span class="medgenPMjournal">J Cardiovasc Pharmacol</span>
|
||
2024 Aug 1;84(2):158-169.
|
||
doi: 10.1097/FJC.0000000000001589.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38922589" target="_blank">38922589</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36336627">Safety and tolerability of solifenacin in children and adolescents with overactive bladder- a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Raman G,
|
||
Tunnicliffe D,
|
||
Lai E,
|
||
Bennett T,
|
||
Caldwell P</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Urol</span>
|
||
2023 Feb;19(1):19.e1-19.e13.
|
||
Epub 2022 Oct 1
|
||
doi: 10.1016/j.jpurol.2022.09.014.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36336627" target="_blank">36336627</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31570667">Abnormal QTc syndrome in HIV-infected patients: a systematic review of prevalence and risk factors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chastain DB,
|
||
Veve MP,
|
||
Wagner JL</span><br />
|
||
<span class="medgenPMjournal">Antivir Ther</span>
|
||
2019;24(6):459-465.
|
||
doi: 10.3851/IMP3335.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31570667" target="_blank">31570667</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29380395">Prolonged corrected QT interval in predicting atrial fibrillation: A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang N,
|
||
Gong M,
|
||
Tse G,
|
||
Zhang Z,
|
||
Meng L,
|
||
Yan BP,
|
||
Zhang L,
|
||
Wu G,
|
||
Xia Y,
|
||
Xin-Yan G,
|
||
Li G,
|
||
Liu T</span><br />
|
||
<span class="medgenPMjournal">Pacing Clin Electrophysiol</span>
|
||
2018 Mar;41(3):321-327.
|
||
Epub 2018 Feb 16
|
||
doi: 10.1111/pace.13292.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29380395" target="_blank">29380395</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28012118">Risk factors for QTc-prolongation: systematic review of the evidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vandael E,
|
||
Vandenberk B,
|
||
Vandenberghe J,
|
||
Willems R,
|
||
Foulon V</span><br />
|
||
<span class="medgenPMjournal">Int J Clin Pharm</span>
|
||
2017 Feb;39(1):16-25.
|
||
Epub 2016 Dec 23
|
||
doi: 10.1007/s11096-016-0414-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28012118" target="_blank">28012118</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Prolonged%20QTc%20interval%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (8)</a></div></div>
|
||
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|
||
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22prolonged%20qtc%20interval%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Prolonged%20QTc%20interval%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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