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<meta name="keywords" content="C1563716, congenital abnormality, dysgenesis, thyroid, thyroid dysgenesis, thyroid dysplasia, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="In 80 to 85% of cases, congenital hypothyroidism is associated with, and presumably is a consequence of, thyroid dysgenesis. In these cases, the thyroid gland can be absent (agenesis), ectopically located, and/or severely reduced in size (hypoplasia). When thyroid hormone therapy is not initiated within the first 2 months of life, congenital hypothyroidism can cause severe neurologic, mental, and motor damage (Macchia et al., 1998)." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
|
||
UID=289647
|
||
ConceptID=C1563716
|
||
-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Thyroid dysgenesis</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>289647</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1563716</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Dysgenesis, Thyroid; Thyroid Dysgenesis</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0008188">HP:0008188</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/218700" target="_blank">218700</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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|
||
<div class="portlet_content ln">In 80 to 85% of cases, congenital hypothyroidism is associated with, and presumably is a consequence of, thyroid dysgenesis. In these cases, the thyroid gland can be absent (agenesis), ectopically located, and/or severely reduced in size (hypoplasia). When thyroid hormone therapy is not initiated within the first 2 months of life, congenital hypothyroidism can cause severe neurologic, mental, and motor damage (Macchia et al., 1998). [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
|
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=289647" target="_blank" href="/omim/218700">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Thyroid dysgenesis</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/893021" ref="tree=MeSH" title="MedGen record for Abnormality of the endocrine system">Abnormality of the endocrine system</a></span><ul><li><span class="TLline"><a href="/medgen/1378579" ref="tree=MeSH" title="MedGen record for Abnormality of the thyroid gland">Abnormality of the thyroid gland</a></span><ul><li><span class="TLline"><a href="/medgen/868790" ref="tree=MeSH" title="MedGen record for Abnormal thyroid morphology">Abnormal thyroid morphology</a></span><ul><li><span class="matched_ds">Thyroid dysgenesis</span><ul><li><span class="TLline"><a href="/medgen/78591" ref="tree=MeSH" title="MedGen record for Ectopic thyroid">Ectopic thyroid</a></span><ul><li><span class="TLline"><a href="/medgen/867994" ref="tree=MeSH" title="MedGen record for Accessory ectopic thyroid tissue">Accessory ectopic thyroid tissue</a></span></li><li><span class="TLline"><a href="/medgen/78592" ref="tree=MeSH" title="MedGen record for Lingual thyroid">Lingual thyroid</a></span><ul><li><span class="TLline"><a href="/medgen/75766" ref="tree=MeSH" title="MedGen record for Lingual goiter">Lingual goiter</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_120514"><div><strong>Pallister-Hall syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>120514</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0265220</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">GLI3-related Pallister-Hall syndrome (GLI3-PHS) is characterized by a spectrum of anomalies ranging from polydactyly, asymptomatic bifid epiglottis, and hypothalamic hamartoma at the mild end to laryngotracheal cleft with neonatal lethality at the severe end. Individuals with mild GLI3-PHS may be incorrectly diagnosed as having isolated postaxial polydactyly type A. Individuals with GLI3-PHS can have pituitary insufficiency and may die as neonates from undiagnosed and untreated adrenal insufficiency.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/120514">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_120514" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pallister-Hall syndrome</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33272083">Congenital Hypothyroidism: A 2020-2021 Consensus Guidelines Update-An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">van Trotsenburg P,
|
||
Stoupa A,
|
||
Léger J,
|
||
Rohrer T,
|
||
Peters C,
|
||
Fugazzola L,
|
||
Cassio A,
|
||
Heinrichs C,
|
||
Beauloye V,
|
||
Pohlenz J,
|
||
Rodien P,
|
||
Coutant R,
|
||
Szinnai G,
|
||
Murray P,
|
||
Bartés B,
|
||
Luton D,
|
||
Salerno M,
|
||
de Sanctis L,
|
||
Vigone M,
|
||
Krude H,
|
||
Persani L,
|
||
Polak M</span><br />
|
||
<span class="medgenPMjournal">Thyroid</span>
|
||
2021 Mar;31(3):387-419.
|
||
doi: 10.1089/thy.2020.0333.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33272083" target="_blank">33272083</a><a href="/pmc/articles/PMC8001676" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30734891">Evaluation and management of the child with hypothyroidism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Leung AKC,
|
||
Leung AAC</span><br />
|
||
<span class="medgenPMjournal">World J Pediatr</span>
|
||
2019 Apr;15(2):124-134.
|
||
Epub 2019 Feb 8
|
||
doi: 10.1007/s12519-019-00230-w.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30734891" target="_blank">30734891</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29650690">The genetic characteristics of congenital hypothyroidism in China by comprehensive screening of 21 candidate genes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sun F,
|
||
Zhang JX,
|
||
Yang CY,
|
||
Gao GQ,
|
||
Zhu WB,
|
||
Han B,
|
||
Zhang LL,
|
||
Wan YY,
|
||
Ye XP,
|
||
Ma YR,
|
||
Zhang MM,
|
||
Yang L,
|
||
Zhang QY,
|
||
Liu W,
|
||
Guo CC,
|
||
Chen G,
|
||
Zhao SX,
|
||
Song KY,
|
||
Song HD</span><br />
|
||
<span class="medgenPMjournal">Eur J Endocrinol</span>
|
||
2018 Jun;178(6):623-633.
|
||
Epub 2018 Apr 12
|
||
doi: 10.1530/EJE-17-1017.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29650690" target="_blank">29650690</a><a href="/pmc/articles/PMC5958289" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22thyroid%20dysgenesis%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (17)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33400193">Genetics of primary congenital hypothyroidism-a review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kostopoulou E,
|
||
Miliordos K,
|
||
Spiliotis B</span><br />
|
||
<span class="medgenPMjournal">Hormones (Athens)</span>
|
||
2021 Jun;20(2):225-236.
|
||
Epub 2021 Jan 5
|
||
doi: 10.1007/s42000-020-00267-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33400193" target="_blank">33400193</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33272083">Congenital Hypothyroidism: A 2020-2021 Consensus Guidelines Update-An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">van Trotsenburg P,
|
||
Stoupa A,
|
||
Léger J,
|
||
Rohrer T,
|
||
Peters C,
|
||
Fugazzola L,
|
||
Cassio A,
|
||
Heinrichs C,
|
||
Beauloye V,
|
||
Pohlenz J,
|
||
Rodien P,
|
||
Coutant R,
|
||
Szinnai G,
|
||
Murray P,
|
||
Bartés B,
|
||
Luton D,
|
||
Salerno M,
|
||
de Sanctis L,
|
||
Vigone M,
|
||
Krude H,
|
||
Persani L,
|
||
Polak M</span><br />
|
||
<span class="medgenPMjournal">Thyroid</span>
|
||
2021 Mar;31(3):387-419.
|
||
doi: 10.1089/thy.2020.0333.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33272083" target="_blank">33272083</a><a href="/pmc/articles/PMC8001676" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32425884">DUOX2 and DUOXA2 Variants Confer Susceptibility to Thyroid Dysgenesis and Gland-in-situ With Congenital Hypothyroidism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang F,
|
||
Zang Y,
|
||
Li M,
|
||
Liu W,
|
||
Wang Y,
|
||
Yu X,
|
||
Li H,
|
||
Wang F,
|
||
Liu S</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2020;11:237.
|
||
Epub 2020 Apr 21
|
||
doi: 10.3389/fendo.2020.00237.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32425884" target="_blank">32425884</a><a href="/pmc/articles/PMC7212429" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29405999">Congenital Hypothyroidism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wassner AJ</span><br />
|
||
<span class="medgenPMjournal">Clin Perinatol</span>
|
||
2018 Mar;45(1):1-18.
|
||
doi: 10.1016/j.clp.2017.10.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29405999" target="_blank">29405999</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24629859">Fetal thyroïdology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Polak M,
|
||
Luton D</span><br />
|
||
<span class="medgenPMjournal">Best Pract Res Clin Endocrinol Metab</span>
|
||
2014 Mar;28(2):161-73.
|
||
Epub 2013 Jun 6
|
||
doi: 10.1016/j.beem.2013.04.013.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24629859" target="_blank">24629859</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Thyroid%20dysgenesis%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (161)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34845088">Congenital Hypothyroidism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brady J,
|
||
Cannupp A,
|
||
Myers J,
|
||
Jnah AJ</span><br />
|
||
<span class="medgenPMjournal">Neonatal Netw</span>
|
||
2021 Nov 1;40(6):377-385.
|
||
doi: 10.1891/11-T-699.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34845088" target="_blank">34845088</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33868182">Resistance to Thyroid Hormone Beta: A Focused Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pappa T,
|
||
Refetoff S</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2021;12:656551.
|
||
Epub 2021 Mar 31
|
||
doi: 10.3389/fendo.2021.656551.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33868182" target="_blank">33868182</a><a href="/pmc/articles/PMC8044682" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33272083">Congenital Hypothyroidism: A 2020-2021 Consensus Guidelines Update-An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">van Trotsenburg P,
|
||
Stoupa A,
|
||
Léger J,
|
||
Rohrer T,
|
||
Peters C,
|
||
Fugazzola L,
|
||
Cassio A,
|
||
Heinrichs C,
|
||
Beauloye V,
|
||
Pohlenz J,
|
||
Rodien P,
|
||
Coutant R,
|
||
Szinnai G,
|
||
Murray P,
|
||
Bartés B,
|
||
Luton D,
|
||
Salerno M,
|
||
de Sanctis L,
|
||
Vigone M,
|
||
Krude H,
|
||
Persani L,
|
||
Polak M</span><br />
|
||
<span class="medgenPMjournal">Thyroid</span>
|
||
2021 Mar;31(3):387-419.
|
||
doi: 10.1089/thy.2020.0333.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33272083" target="_blank">33272083</a><a href="/pmc/articles/PMC8001676" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29405999">Congenital Hypothyroidism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wassner AJ</span><br />
|
||
<span class="medgenPMjournal">Clin Perinatol</span>
|
||
2018 Mar;45(1):1-18.
|
||
doi: 10.1016/j.clp.2017.10.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29405999" target="_blank">29405999</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24629859">Fetal thyroïdology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Polak M,
|
||
Luton D</span><br />
|
||
<span class="medgenPMjournal">Best Pract Res Clin Endocrinol Metab</span>
|
||
2014 Mar;28(2):161-73.
|
||
Epub 2013 Jun 6
|
||
doi: 10.1016/j.beem.2013.04.013.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24629859" target="_blank">24629859</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Thyroid%20dysgenesis%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (317)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35370986">Congenital Hypothyroidism in Preterm Newborns - The Challenges of Diagnostics and Treatment: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Klosinska M,
|
||
Kaczynska A,
|
||
Ben-Skowronek I</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2022;13:860862.
|
||
Epub 2022 Mar 18
|
||
doi: 10.3389/fendo.2022.860862.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35370986" target="_blank">35370986</a><a href="/pmc/articles/PMC8972126" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29405999">Congenital Hypothyroidism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wassner AJ</span><br />
|
||
<span class="medgenPMjournal">Clin Perinatol</span>
|
||
2018 Mar;45(1):1-18.
|
||
doi: 10.1016/j.clp.2017.10.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29405999" target="_blank">29405999</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24629859">Fetal thyroïdology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Polak M,
|
||
Luton D</span><br />
|
||
<span class="medgenPMjournal">Best Pract Res Clin Endocrinol Metab</span>
|
||
2014 Mar;28(2):161-73.
|
||
Epub 2013 Jun 6
|
||
doi: 10.1016/j.beem.2013.04.013.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24629859" target="_blank">24629859</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22281882">Ectopic thyroid: etiology, pathology and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ibrahim NA,
|
||
Fadeyibi IO</span><br />
|
||
<span class="medgenPMjournal">Hormones (Athens)</span>
|
||
2011 Oct-Dec;10(4):261-9.
|
||
doi: 10.14310/horm.2002.1317.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22281882" target="_blank">22281882</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2661716">Congenital hypothyroidism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gravdal JA,
|
||
Meenan A,
|
||
Dyson AE</span><br />
|
||
<span class="medgenPMjournal">J Fam Pract</span>
|
||
1989 Jul;29(1):47-50.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2661716" target="_blank">2661716</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Thyroid%20dysgenesis%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (77)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33272083">Congenital Hypothyroidism: A 2020-2021 Consensus Guidelines Update-An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">van Trotsenburg P,
|
||
Stoupa A,
|
||
Léger J,
|
||
Rohrer T,
|
||
Peters C,
|
||
Fugazzola L,
|
||
Cassio A,
|
||
Heinrichs C,
|
||
Beauloye V,
|
||
Pohlenz J,
|
||
Rodien P,
|
||
Coutant R,
|
||
Szinnai G,
|
||
Murray P,
|
||
Bartés B,
|
||
Luton D,
|
||
Salerno M,
|
||
de Sanctis L,
|
||
Vigone M,
|
||
Krude H,
|
||
Persani L,
|
||
Polak M</span><br />
|
||
<span class="medgenPMjournal">Thyroid</span>
|
||
2021 Mar;31(3):387-419.
|
||
doi: 10.1089/thy.2020.0333.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33272083" target="_blank">33272083</a><a href="/pmc/articles/PMC8001676" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32425884">DUOX2 and DUOXA2 Variants Confer Susceptibility to Thyroid Dysgenesis and Gland-in-situ With Congenital Hypothyroidism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang F,
|
||
Zang Y,
|
||
Li M,
|
||
Liu W,
|
||
Wang Y,
|
||
Yu X,
|
||
Li H,
|
||
Wang F,
|
||
Liu S</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2020;11:237.
|
||
Epub 2020 Apr 21
|
||
doi: 10.3389/fendo.2020.00237.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32425884" target="_blank">32425884</a><a href="/pmc/articles/PMC7212429" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29405999">Congenital Hypothyroidism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wassner AJ</span><br />
|
||
<span class="medgenPMjournal">Clin Perinatol</span>
|
||
2018 Mar;45(1):1-18.
|
||
doi: 10.1016/j.clp.2017.10.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29405999" target="_blank">29405999</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25439547">Thyroglossal duct cyst and ectopic thyroid: surgical management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Oomen KP,
|
||
Modi VK,
|
||
Maddalozzo J</span><br />
|
||
<span class="medgenPMjournal">Otolaryngol Clin North Am</span>
|
||
2015 Feb;48(1):15-27.
|
||
doi: 10.1016/j.otc.2014.09.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25439547" target="_blank">25439547</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2661716">Congenital hypothyroidism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gravdal JA,
|
||
Meenan A,
|
||
Dyson AE</span><br />
|
||
<span class="medgenPMjournal">J Fam Pract</span>
|
||
1989 Jul;29(1):47-50.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2661716" target="_blank">2661716</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Thyroid%20dysgenesis%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (97)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34969265">Severe Resistance to Thyroid Hormone Beta in a Patient with Athyreosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Salas-Lucia F,
|
||
França MM,
|
||
Amrhein JA,
|
||
Weir JE,
|
||
Dumitrescu AM,
|
||
Refetoff S</span><br />
|
||
<span class="medgenPMjournal">Thyroid</span>
|
||
2022 Mar;32(3):336-339.
|
||
doi: 10.1089/thy.2021.0523.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34969265" target="_blank">34969265</a><a href="/pmc/articles/PMC8971974" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34539567">Genetic and Phenotypic Characteristics of Congenital Hypothyroidism in a Chinese Cohort.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Long W,
|
||
Guo F,
|
||
Yao R,
|
||
Wang Y,
|
||
Wang H,
|
||
Yu B,
|
||
Xue P</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2021;12:705773.
|
||
Epub 2021 Sep 3
|
||
doi: 10.3389/fendo.2021.705773.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34539567" target="_blank">34539567</a><a href="/pmc/articles/PMC8446595" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33272083">Congenital Hypothyroidism: A 2020-2021 Consensus Guidelines Update-An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">van Trotsenburg P,
|
||
Stoupa A,
|
||
Léger J,
|
||
Rohrer T,
|
||
Peters C,
|
||
Fugazzola L,
|
||
Cassio A,
|
||
Heinrichs C,
|
||
Beauloye V,
|
||
Pohlenz J,
|
||
Rodien P,
|
||
Coutant R,
|
||
Szinnai G,
|
||
Murray P,
|
||
Bartés B,
|
||
Luton D,
|
||
Salerno M,
|
||
de Sanctis L,
|
||
Vigone M,
|
||
Krude H,
|
||
Persani L,
|
||
Polak M</span><br />
|
||
<span class="medgenPMjournal">Thyroid</span>
|
||
2021 Mar;31(3):387-419.
|
||
doi: 10.1089/thy.2020.0333.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33272083" target="_blank">33272083</a><a href="/pmc/articles/PMC8001676" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29650690">The genetic characteristics of congenital hypothyroidism in China by comprehensive screening of 21 candidate genes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sun F,
|
||
Zhang JX,
|
||
Yang CY,
|
||
Gao GQ,
|
||
Zhu WB,
|
||
Han B,
|
||
Zhang LL,
|
||
Wan YY,
|
||
Ye XP,
|
||
Ma YR,
|
||
Zhang MM,
|
||
Yang L,
|
||
Zhang QY,
|
||
Liu W,
|
||
Guo CC,
|
||
Chen G,
|
||
Zhao SX,
|
||
Song KY,
|
||
Song HD</span><br />
|
||
<span class="medgenPMjournal">Eur J Endocrinol</span>
|
||
2018 Jun;178(6):623-633.
|
||
Epub 2018 Apr 12
|
||
doi: 10.1530/EJE-17-1017.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29650690" target="_blank">29650690</a><a href="/pmc/articles/PMC5958289" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2661716">Congenital hypothyroidism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gravdal JA,
|
||
Meenan A,
|
||
Dyson AE</span><br />
|
||
<span class="medgenPMjournal">J Fam Pract</span>
|
||
1989 Jul;29(1):47-50.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2661716" target="_blank">2661716</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Thyroid%20dysgenesis%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (113)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/34302303">A systematic review of the outcomes of false-positive results on newborn screening for congenital hypothyroidism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rosettenstein KR,
|
||
Lain SJ,
|
||
Wormleaton N,
|
||
Jack MM</span><br />
|
||
<span class="medgenPMjournal">Clin Endocrinol (Oxf)</span>
|
||
2021 Nov;95(5):766-781.
|
||
Epub 2021 Jul 23
|
||
doi: 10.1111/cen.14562.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34302303" target="_blank">34302303</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23698639">The molecular causes of thyroid dysgenesis: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nettore IC,
|
||
Cacace V,
|
||
De Fusco C,
|
||
Colao A,
|
||
Macchia PE</span><br />
|
||
<span class="medgenPMjournal">J Endocrinol Invest</span>
|
||
2013 Sep;36(8):654-64.
|
||
Epub 2013 May 22
|
||
doi: 10.3275/8973.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23698639" target="_blank">23698639</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Thyroid%20dysgenesis%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
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|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
|
||
<div class="rightCol mgCol">
|
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<div class="portlet mgSection" id="ID_113">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Thyroid%20dysgenesis" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22thyroid%20dysgenesis%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Thyroid%20dysgenesis%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="https://www.malacards.org/card/hypothyroidism_congenital_nongoitrous_2" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Thyroid%20dysgenesis" target="_blank">MedlinePlus</a></li></ul></div>
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<a href="/pubmed/clinical?term=Thyroid%20dysgenesis" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
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<a href="/pubmed?term=Thyroid%20dysgenesis%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67d4115584f3725e597a8717">Thyroid dysgenesis</a>
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<div class="ralinkpop offscreen_noflow">Thyroid dysgenesis<div class="brieflinkpopdesc"></div></div>
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<div class="tertiary">MedGen</div>
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