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<meta name="keywords" content="C1332937, childhood acute erythroid leukemia, childhood m6 leukemia, neoplastic process, pediatric acute erythroid leukemia, pediatric m6 leukemia, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="An acute erythroid leukemia occurring in children." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Childhood Acute Erythroid Leukemia (Concept Id: C1332937)
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<!--
UID=232341
ConceptID=C1332937
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Childhood Acute Erythroid Leukemia</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>232341</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1332937</a></dd><dt><span class="dotprefix"></span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Childhood M6 Leukemia; Pediatric Acute Erythroid Leukemia; Pediatric M6 Leukemia</td></tr>
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">An acute erythroid leukemia occurring in children. [from <a title="NCI Thesaurus" href="http://ncit.nci.nih.gov" class="defSource" target="_blank">NCI</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Childhood Acute Erythroid Leukemia</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/5483" ref="tree=MeSH" title="MedGen record for Hematologic disorder">Hematologic disorder</a></span><ul><li><span class="TLline"><a href="/medgen/138213" ref="tree=MeSH" title="MedGen record for Hematologic neoplasm">Hematologic neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/9725" ref="tree=MeSH" title="MedGen record for Leukemia">Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/43225" ref="tree=MeSH" title="MedGen record for Acute leukemia">Acute leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/9730" ref="tree=MeSH" title="MedGen record for Acute myeloid leukemia">Acute myeloid leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/7316" ref="tree=MeSH" title="MedGen record for Acute myeloid leukemia, M6 type">Acute myeloid leukemia, M6 type</a></span><ul><li><span class="matched_ds">Childhood Acute Erythroid Leukemia</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/23700063">Development of a curative treatment within the AML-BFM studies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Creutzig U,
Zimmermann M,
Dworzak MN,
Ritter J,
Schellong G,
Reinhardt D</span><br />
<span class="medgenPMjournal">Klin Padiatr</span>
2013 May;225 Suppl 1:S79-86.
Epub 2013 May 22
doi: 10.1055/s-0033-1337968.
<span class="bold">PMID: </span><a href="/pubmed/23700063" target="_blank">23700063</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19434599">Treatment refusal and abandonment in childhood acute lymphoblastic leukemia in Indonesia: an analysis of causes and consequences.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sitaresmi MN,
Mostert S,
Schook RM;
Sutaryo,
Veerman AJ</span><br />
<span class="medgenPMjournal">Psychooncology</span>
2010 Apr;19(4):361-7.
doi: 10.1002/pon.1578.
<span class="bold">PMID: </span><a href="/pubmed/19434599" target="_blank">19434599</a></div>
<div class="nl"><a target="_blank" href="/pubmed/1058045">Adriamycin in the treatment of childhood acute leukemia. A Southwest Oncology Group study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ragab AH,
Sutow WW,
Komp DM,
Starling KA,
Lyon GM Jr,
George S</span><br />
<span class="medgenPMjournal">Cancer</span>
1975 Oct;36(4):1223-6.
doi: 10.1002/1097-0142(197510)36:4&lt;1223::aid-cncr2820360407&gt;3.0.co;2-7.
<span class="bold">PMID: </span><a href="/pubmed/1058045" target="_blank">1058045</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(childhood%20acute%20erythroid%20leukemia)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (4)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/36439178">Integrating RNA-seq and scRNA-seq to explore the biological significance of NAD + metabolism-related genes in the initial diagnosis and relapse of childhood B-cell acute lymphoblastic leukemia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lin C,
Xu JQ,
Zhong GC,
Chen H,
Xue HM,
Yang M,
Chen C</span><br />
<span class="medgenPMjournal">Front Immunol</span>
2022;13:1043111.
Epub 2022 Nov 11
doi: 10.3389/fimmu.2022.1043111.
<span class="bold">PMID: </span><a href="/pubmed/36439178" target="_blank">36439178</a><a href="/pmc/articles/PMC9691973" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30926971">Genomic subtyping and therapeutic targeting of acute erythroleukemia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Iacobucci I,
Wen J,
Meggendorfer M,
Choi JK,
Shi L,
Pounds SB,
Carmichael CL,
Masih KE,
Morris SM,
Lindsley RC,
Janke LJ,
Alexander TB,
Song G,
Qu C,
Li Y,
Payne-Turner D,
Tomizawa D,
Kiyokawa N,
Valentine M,
Valentine V,
Basso G,
Locatelli F,
Enemark EJ,
Kham SKY,
Yeoh AEJ,
Ma X,
Zhou X,
Sioson E,
Rusch M,
Ries RE,
Stieglitz E,
Hunger SP,
Wei AH,
To LB,
Lewis ID,
D'Andrea RJ,
Kile BT,
Brown AL,
Scott HS,
Hahn CN,
Marlton P,
Pei D,
Cheng C,
Loh ML,
Ebert BL,
Meshinchi S,
Haferlach T,
Mullighan CG</span><br />
<span class="medgenPMjournal">Nat Genet</span>
2019 Apr;51(4):694-704.
Epub 2019 Mar 29
doi: 10.1038/s41588-019-0375-1.
<span class="bold">PMID: </span><a href="/pubmed/30926971" target="_blank">30926971</a><a href="/pmc/articles/PMC6828160" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23700063">Development of a curative treatment within the AML-BFM studies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Creutzig U,
Zimmermann M,
Dworzak MN,
Ritter J,
Schellong G,
Reinhardt D</span><br />
<span class="medgenPMjournal">Klin Padiatr</span>
2013 May;225 Suppl 1:S79-86.
Epub 2013 May 22
doi: 10.1055/s-0033-1337968.
<span class="bold">PMID: </span><a href="/pubmed/23700063" target="_blank">23700063</a></div>
<div class="nl"><a target="_blank" href="/pubmed/6574421">Chromosome studies on acute nonlymphocytic leukaemia in children.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Slater RM,
Behrendt H,
De Waal FC</span><br />
<span class="medgenPMjournal">Pediatr Res</span>
1983 May;17(5):398-405.
doi: 10.1203/00006450-198305000-00016.
<span class="bold">PMID: </span><a href="/pubmed/6574421" target="_blank">6574421</a></div>
<div class="nl"><a target="_blank" href="/pubmed/287549">Acute nonlymphoblastic leukemia in childhood.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Morse H,
Hays T,
Peakman D,
Rose B,
Robinson A</span><br />
<span class="medgenPMjournal">Cancer</span>
1979 Jul;44(1):164-70.
doi: 10.1002/1097-0142(197907)44:1&lt;164::aid-cncr2820440128&gt;3.0.co;2-9.
<span class="bold">PMID: </span><a href="/pubmed/287549" target="_blank">287549</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Childhood%20Acute%20Erythroid%20Leukemia%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (28)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/37729615">CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia is sensitive to BCL-XL inhibition by navitoclax and DT2216.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gress V,
Roussy M,
Boulianne L,
Bilodeau M,
Cardin S,
El-Hachem N,
Lisi V,
Khakipoor B,
Rouette A,
Farah A,
Théret L,
Aubert L,
Fatima F,
Audemard É,
Thibault P,
Bonneil É,
Chagraoui J,
Laramée L,
Gendron P,
Jouan L,
Jammali S,
Paré B,
Simpson SM,
Tran TH,
Duval M,
Teira P,
Bittencourt H,
Santiago R,
Barabé F,
Sauvageau G,
Smith MA,
Hébert J,
Roux PP,
Gruber TA,
Lavallée VP,
Wilhelm BT,
Cellot S</span><br />
<span class="medgenPMjournal">Blood Adv</span>
2024 Jan 9;8(1):112-129.
doi: 10.1182/bloodadvances.2022008899.
<span class="bold">PMID: </span><a href="/pubmed/37729615" target="_blank">37729615</a><a href="/pmc/articles/PMC10787250" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36439178">Integrating RNA-seq and scRNA-seq to explore the biological significance of NAD + metabolism-related genes in the initial diagnosis and relapse of childhood B-cell acute lymphoblastic leukemia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lin C,
Xu JQ,
Zhong GC,
Chen H,
Xue HM,
Yang M,
Chen C</span><br />
<span class="medgenPMjournal">Front Immunol</span>
2022;13:1043111.
Epub 2022 Nov 11
doi: 10.3389/fimmu.2022.1043111.
<span class="bold">PMID: </span><a href="/pubmed/36439178" target="_blank">36439178</a><a href="/pmc/articles/PMC9691973" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30926971">Genomic subtyping and therapeutic targeting of acute erythroleukemia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Iacobucci I,
Wen J,
Meggendorfer M,
Choi JK,
Shi L,
Pounds SB,
Carmichael CL,
Masih KE,
Morris SM,
Lindsley RC,
Janke LJ,
Alexander TB,
Song G,
Qu C,
Li Y,
Payne-Turner D,
Tomizawa D,
Kiyokawa N,
Valentine M,
Valentine V,
Basso G,
Locatelli F,
Enemark EJ,
Kham SKY,
Yeoh AEJ,
Ma X,
Zhou X,
Sioson E,
Rusch M,
Ries RE,
Stieglitz E,
Hunger SP,
Wei AH,
To LB,
Lewis ID,
D'Andrea RJ,
Kile BT,
Brown AL,
Scott HS,
Hahn CN,
Marlton P,
Pei D,
Cheng C,
Loh ML,
Ebert BL,
Meshinchi S,
Haferlach T,
Mullighan CG</span><br />
<span class="medgenPMjournal">Nat Genet</span>
2019 Apr;51(4):694-704.
Epub 2019 Mar 29
doi: 10.1038/s41588-019-0375-1.
<span class="bold">PMID: </span><a href="/pubmed/30926971" target="_blank">30926971</a><a href="/pmc/articles/PMC6828160" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/2660543">Congenital erythroleukemia: a case report with morphological, immunophenotypic, and cytogenetic findings.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Allan RR,
Wadsworth LD,
Kalousek DK,
Massing BG</span><br />
<span class="medgenPMjournal">Am J Hematol</span>
1989 Jun;31(2):114-21.
doi: 10.1002/ajh.2830310208.
<span class="bold">PMID: </span><a href="/pubmed/2660543" target="_blank">2660543</a></div>
<div class="nl"><a target="_blank" href="/pubmed/6574421">Chromosome studies on acute nonlymphocytic leukaemia in children.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Slater RM,
Behrendt H,
De Waal FC</span><br />
<span class="medgenPMjournal">Pediatr Res</span>
1983 May;17(5):398-405.
doi: 10.1203/00006450-198305000-00016.
<span class="bold">PMID: </span><a href="/pubmed/6574421" target="_blank">6574421</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Childhood%20Acute%20Erythroid%20Leukemia%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (44)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/36439178">Integrating RNA-seq and scRNA-seq to explore the biological significance of NAD + metabolism-related genes in the initial diagnosis and relapse of childhood B-cell acute lymphoblastic leukemia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lin C,
Xu JQ,
Zhong GC,
Chen H,
Xue HM,
Yang M,
Chen C</span><br />
<span class="medgenPMjournal">Front Immunol</span>
2022;13:1043111.
Epub 2022 Nov 11
doi: 10.3389/fimmu.2022.1043111.
<span class="bold">PMID: </span><a href="/pubmed/36439178" target="_blank">36439178</a><a href="/pmc/articles/PMC9691973" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24239851">Erythropoietin-induced acute erythroid leukemia-like picture: a potential pitfall.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Moharram L,
Kamal N,
Al Sukhun S,
Sughayer MA</span><br />
<span class="medgenPMjournal">Hematol Oncol Stem Cell Ther</span>
2014 Mar;7(1):50-2.
Epub 2013 Nov 14
doi: 10.1016/j.hemonc.2013.09.004.
<span class="bold">PMID: </span><a href="/pubmed/24239851" target="_blank">24239851</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23700063">Development of a curative treatment within the AML-BFM studies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Creutzig U,
Zimmermann M,
Dworzak MN,
Ritter J,
Schellong G,
Reinhardt D</span><br />
<span class="medgenPMjournal">Klin Padiatr</span>
2013 May;225 Suppl 1:S79-86.
Epub 2013 May 22
doi: 10.1055/s-0033-1337968.
<span class="bold">PMID: </span><a href="/pubmed/23700063" target="_blank">23700063</a></div>
<div class="nl"><a target="_blank" href="/pubmed/6174053">Myeloproliferative diseases in childhood.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Nix WL,
Fernbach DJ</span><br />
<span class="medgenPMjournal">Am J Pediatr Hematol Oncol</span>
1981 Winter;3(4):397-407.
<span class="bold">PMID: </span><a href="/pubmed/6174053" target="_blank">6174053</a></div>
<div class="nl"><a target="_blank" href="/pubmed/81412">Controlled study of hypertransfusion during remission induction in childhood acute lymphocytic leukaemia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Toogood IR,
Ekert H,
Smith PJ</span><br />
<span class="medgenPMjournal">Lancet</span>
1978 Oct 21;2(8095):862-4.
doi: 10.1016/s0140-6736(78)91570-2.
<span class="bold">PMID: </span><a href="/pubmed/81412" target="_blank">81412</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Childhood%20Acute%20Erythroid%20Leukemia%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (15)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/30926971">Genomic subtyping and therapeutic targeting of acute erythroleukemia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Iacobucci I,
Wen J,
Meggendorfer M,
Choi JK,
Shi L,
Pounds SB,
Carmichael CL,
Masih KE,
Morris SM,
Lindsley RC,
Janke LJ,
Alexander TB,
Song G,
Qu C,
Li Y,
Payne-Turner D,
Tomizawa D,
Kiyokawa N,
Valentine M,
Valentine V,
Basso G,
Locatelli F,
Enemark EJ,
Kham SKY,
Yeoh AEJ,
Ma X,
Zhou X,
Sioson E,
Rusch M,
Ries RE,
Stieglitz E,
Hunger SP,
Wei AH,
To LB,
Lewis ID,
D'Andrea RJ,
Kile BT,
Brown AL,
Scott HS,
Hahn CN,
Marlton P,
Pei D,
Cheng C,
Loh ML,
Ebert BL,
Meshinchi S,
Haferlach T,
Mullighan CG</span><br />
<span class="medgenPMjournal">Nat Genet</span>
2019 Apr;51(4):694-704.
Epub 2019 Mar 29
doi: 10.1038/s41588-019-0375-1.
<span class="bold">PMID: </span><a href="/pubmed/30926971" target="_blank">30926971</a><a href="/pmc/articles/PMC6828160" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26159683">Prognostic factors of childhood and adolescent acute myeloid leukemia (AML) survival: evidence from four decades of US population data.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hossain MJ,
Xie L,
Caywood EH</span><br />
<span class="medgenPMjournal">Cancer Epidemiol</span>
2015 Oct;39(5):720-6.
Epub 2015 Jul 6
doi: 10.1016/j.canep.2015.06.009.
<span class="bold">PMID: </span><a href="/pubmed/26159683" target="_blank">26159683</a><a href="/pmc/articles/PMC6398442" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23700063">Development of a curative treatment within the AML-BFM studies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Creutzig U,
Zimmermann M,
Dworzak MN,
Ritter J,
Schellong G,
Reinhardt D</span><br />
<span class="medgenPMjournal">Klin Padiatr</span>
2013 May;225 Suppl 1:S79-86.
Epub 2013 May 22
doi: 10.1055/s-0033-1337968.
<span class="bold">PMID: </span><a href="/pubmed/23700063" target="_blank">23700063</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21321361">Promotion and maintenance of leukemia by ERG.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tsuzuki S,
Taguchi O,
Seto M</span><br />
<span class="medgenPMjournal">Blood</span>
2011 Apr 7;117(14):3858-68.
Epub 2011 Feb 14
doi: 10.1182/blood-2010-11-320515.
<span class="bold">PMID: </span><a href="/pubmed/21321361" target="_blank">21321361</a></div>
<div class="nl"><a target="_blank" href="/pubmed/2660543">Congenital erythroleukemia: a case report with morphological, immunophenotypic, and cytogenetic findings.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Allan RR,
Wadsworth LD,
Kalousek DK,
Massing BG</span><br />
<span class="medgenPMjournal">Am J Hematol</span>
1989 Jun;31(2):114-21.
doi: 10.1002/ajh.2830310208.
<span class="bold">PMID: </span><a href="/pubmed/2660543" target="_blank">2660543</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Childhood%20Acute%20Erythroid%20Leukemia%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (26)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/26520618">Sex disparity in childhood and young adult acute myeloid leukemia (AML) survival: Evidence from US population data.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hossain MJ,
Xie L</span><br />
<span class="medgenPMjournal">Cancer Epidemiol</span>
2015 Dec;39(6):892-900.
Epub 2015 Nov 9
doi: 10.1016/j.canep.2015.10.020.
<span class="bold">PMID: </span><a href="/pubmed/26520618" target="_blank">26520618</a><a href="/pmc/articles/PMC4679651" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/15895080">Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Li Z,
Godinho FJ,
Klusmann JH,
Garriga-Canut M,
Yu C,
Orkin SH</span><br />
<span class="medgenPMjournal">Nat Genet</span>
2005 Jun;37(6):613-9.
Epub 2005 May 15
doi: 10.1038/ng1566.
<span class="bold">PMID: </span><a href="/pubmed/15895080" target="_blank">15895080</a></div>
<div class="nl"><a target="_blank" href="/pubmed/14656875">Natural history of GATA1 mutations in Down syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ahmed M,
Sternberg A,
Hall G,
Thomas A,
Smith O,
O'Marcaigh A,
Wynn R,
Stevens R,
Addison M,
King D,
Stewart B,
Gibson B,
Roberts I,
Vyas P</span><br />
<span class="medgenPMjournal">Blood</span>
2004 Apr 1;103(7):2480-9.
Epub 2003 Dec 4
doi: 10.1182/blood-2003-10-3383.
<span class="bold">PMID: </span><a href="/pubmed/14656875" target="_blank">14656875</a></div>
<div class="nl"><a target="_blank" href="/pubmed/2043763">Expression of embryonic globins by erythroid cells in juvenile chronic myelocytic leukemia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Papayannopoulou T,
Nakamoto B,
Anagnou NP,
Chui D,
Dow L,
Sanders J</span><br />
<span class="medgenPMjournal">Blood</span>
1991 Jun 15;77(12):2569-76.
<span class="bold">PMID: </span><a href="/pubmed/2043763" target="_blank">2043763</a></div>
<div class="nl"><a target="_blank" href="/pubmed/3460625">Acute myeloid leukaemia in childhood: clinical features and prognosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chessells JM,
O'Callaghan U,
Hardisty RM</span><br />
<span class="medgenPMjournal">Br J Haematol</span>
1986 Jul;63(3):555-64.
doi: 10.1111/j.1365-2141.1986.tb07533.x.
<span class="bold">PMID: </span><a href="/pubmed/3460625" target="_blank">3460625</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Childhood%20Acute%20Erythroid%20Leukemia%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (12)</a></div></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(childhood%20acute%20erythroid%20leukemia)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Childhood%20Acute%20Erythroid%20Leukemia%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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