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<meta name="keywords" content="C1297929, atypical breast hyperplasia, atypical hyperplasia of breast, atypical hyperplasia of the breast, breast atypical hyperplasia, pathologic function, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A general term that refers to atypical hyperplastic proliferations of the epithelial cells in the breast parenchyma. Examples include atypical ductal hyperplasia, atypical lobular hyperplasia, and columnar cell hyperplasia with atypia." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Atypical hyperplasia of breast (Concept Id: C1297929)
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<!--
UID=226961
ConceptID=C1297929
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Atypical hyperplasia of breast</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>226961</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1297929</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pathologic Function</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Atypical Breast Hyperplasia; Atypical Hyperplasia of Breast; Atypical Hyperplasia of the Breast; Breast Atypical Hyperplasia</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Atypical hyperplasia of breast (369462000)</td></tr>
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">A general term that refers to atypical hyperplastic proliferations of the epithelial cells in the breast parenchyma. Examples include atypical ductal hyperplasia, atypical lobular hyperplasia, and columnar cell hyperplasia with atypia. [from <a title="NCI Thesaurus" href="http://ncit.nci.nih.gov" class="defSource" target="_blank">NCI</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Atypical hyperplasia of breast</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/311052" ref="tree=MeSH" title="MedGen record for Non-Neoplastic Disorder">Non-Neoplastic Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/317955" ref="tree=MeSH" title="MedGen record for Non-Neoplastic Disorder by Special Category">Non-Neoplastic Disorder by Special Category</a></span><ul><li><span class="TLline"><a href="/medgen/43784" ref="tree=MeSH" title="MedGen record for Hyperplasia">Hyperplasia</a></span><ul><li><span class="TLline"><a href="/medgen/90732" ref="tree=MeSH" title="MedGen record for Atypical hyperplasia">Atypical hyperplasia</a></span><ul><li><span class="matched_ds">Atypical hyperplasia of breast</span><ul><li><span class="TLline"><a href="/medgen/277968" ref="tree=MeSH" title="MedGen record for Atypical lobular breast hyperplasia">Atypical lobular breast hyperplasia</a></span></li><li><span class="TLline"><a href="/medgen/272327" ref="tree=MeSH" title="MedGen record for Breast Atypical Ductal Hyperplasia">Breast Atypical Ductal Hyperplasia</a></span></li><li><span class="TLline"><a href="/medgen/267760" ref="tree=MeSH" title="MedGen record for Breast Atypical Myoepitheliosis">Breast Atypical Myoepitheliosis</a></span></li><li><span class="TLline"><a href="/medgen/317528" ref="tree=MeSH" title="MedGen record for Breast Columnar Cell Hyperplasia with Atypia">Breast Columnar Cell Hyperplasia with Atypia</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/38061151">European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Rubio IT,
Wyld L,
Marotti L,
Athanasiou A,
Regitnig P,
Catanuto G,
Schoones JW,
Zambon M,
Camps J,
Santini D,
Dietz J,
Sardanelli F,
Varga Z,
Smidt M,
Sharma N,
Shaaban AM,
Gilbert F</span><br />
<span class="medgenPMjournal">Eur J Surg Oncol</span>
2024 Jan;50(1):107292.
Epub 2023 Nov 27
doi: 10.1016/j.ejso.2023.107292.
<span class="bold">PMID: </span><a href="/pubmed/38061151" target="_blank">38061151</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33106592">Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Brogi E,
Krystel-Whittemore M</span><br />
<span class="medgenPMjournal">Mod Pathol</span>
2021 Jan;34(Suppl 1):78-93.
Epub 2020 Oct 26
doi: 10.1038/s41379-020-00706-5.
<span class="bold">PMID: </span><a href="/pubmed/33106592" target="_blank">33106592</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25551530">Atypical hyperplasia of the breast--risk assessment and management options.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hartmann LC,
Degnim AC,
Santen RJ,
Dupont WD,
Ghosh K</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2015 Jan 1;372(1):78-89.
doi: 10.1056/NEJMsr1407164.
<span class="bold">PMID: </span><a href="/pubmed/25551530" target="_blank">25551530</a><a href="/pmc/articles/PMC4347900" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(atypical%20hyperplasia%20of%20breast)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (137)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/38061151">European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Rubio IT,
Wyld L,
Marotti L,
Athanasiou A,
Regitnig P,
Catanuto G,
Schoones JW,
Zambon M,
Camps J,
Santini D,
Dietz J,
Sardanelli F,
Varga Z,
Smidt M,
Sharma N,
Shaaban AM,
Gilbert F</span><br />
<span class="medgenPMjournal">Eur J Surg Oncol</span>
2024 Jan;50(1):107292.
Epub 2023 Nov 27
doi: 10.1016/j.ejso.2023.107292.
<span class="bold">PMID: </span><a href="/pubmed/38061151" target="_blank">38061151</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36335930">Lobular Neoplasia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lunt L,
Coogan A,
Perez CB</span><br />
<span class="medgenPMjournal">Surg Clin North Am</span>
2022 Dec;102(6):947-963.
doi: 10.1016/j.suc.2022.07.001.
<span class="bold">PMID: </span><a href="/pubmed/36335930" target="_blank">36335930</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33222998">Management of High-Risk Breast Lesions.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bahl M</span><br />
<span class="medgenPMjournal">Radiol Clin North Am</span>
2021 Jan;59(1):29-40.
doi: 10.1016/j.rcl.2020.08.005.
<span class="bold">PMID: </span><a href="/pubmed/33222998" target="_blank">33222998</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33106592">Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Brogi E,
Krystel-Whittemore M</span><br />
<span class="medgenPMjournal">Mod Pathol</span>
2021 Jan;34(Suppl 1):78-93.
Epub 2020 Oct 26
doi: 10.1038/s41379-020-00706-5.
<span class="bold">PMID: </span><a href="/pubmed/33106592" target="_blank">33106592</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25551530">Atypical hyperplasia of the breast--risk assessment and management options.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hartmann LC,
Degnim AC,
Santen RJ,
Dupont WD,
Ghosh K</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2015 Jan 1;372(1):78-89.
doi: 10.1056/NEJMsr1407164.
<span class="bold">PMID: </span><a href="/pubmed/25551530" target="_blank">25551530</a><a href="/pmc/articles/PMC4347900" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Atypical%20hyperplasia%20of%20breast%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1236)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/38061151">European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Rubio IT,
Wyld L,
Marotti L,
Athanasiou A,
Regitnig P,
Catanuto G,
Schoones JW,
Zambon M,
Camps J,
Santini D,
Dietz J,
Sardanelli F,
Varga Z,
Smidt M,
Sharma N,
Shaaban AM,
Gilbert F</span><br />
<span class="medgenPMjournal">Eur J Surg Oncol</span>
2024 Jan;50(1):107292.
Epub 2023 Nov 27
doi: 10.1016/j.ejso.2023.107292.
<span class="bold">PMID: </span><a href="/pubmed/38061151" target="_blank">38061151</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37400158">Atypical hyperplasia of the breast: Clinical cases and management strategies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Vegunta S,
Mussallem DM,
Kaur AS,
Pruthi S,
Klassen CL</span><br />
<span class="medgenPMjournal">Cleve Clin J Med</span>
2023 Jul 3;90(7):423-431.
doi: 10.3949/ccjm.90a.22098.
<span class="bold">PMID: </span><a href="/pubmed/37400158" target="_blank">37400158</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36335930">Lobular Neoplasia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lunt L,
Coogan A,
Perez CB</span><br />
<span class="medgenPMjournal">Surg Clin North Am</span>
2022 Dec;102(6):947-963.
doi: 10.1016/j.suc.2022.07.001.
<span class="bold">PMID: </span><a href="/pubmed/36335930" target="_blank">36335930</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34537861">Apocrine lesions of the breast.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Quinn CM,
D'Arcy C,
Wells C</span><br />
<span class="medgenPMjournal">Virchows Arch</span>
2022 Jan;480(1):177-189.
Epub 2021 Sep 18
doi: 10.1007/s00428-021-03185-4.
<span class="bold">PMID: </span><a href="/pubmed/34537861" target="_blank">34537861</a><a href="/pmc/articles/PMC8983539" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33106592">Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Brogi E,
Krystel-Whittemore M</span><br />
<span class="medgenPMjournal">Mod Pathol</span>
2021 Jan;34(Suppl 1):78-93.
Epub 2020 Oct 26
doi: 10.1038/s41379-020-00706-5.
<span class="bold">PMID: </span><a href="/pubmed/33106592" target="_blank">33106592</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Atypical%20hyperplasia%20of%20breast%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1209)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/36917758">Randomized Placebo Controlled Trial of Low-Dose Tamoxifen to Prevent Recurrence in Breast Noninvasive Neoplasia: A 10-Year Follow-Up of TAM-01 Study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lazzeroni M,
Puntoni M,
Guerrieri-Gonzaga A,
Serrano D,
Boni L,
Buttiron Webber T,
Fava M,
Briata IM,
Giordano L,
Digennaro M,
Cortesi L,
Falcini F,
Serra P,
Avino F,
Millo F,
Cagossi K,
Gallerani E,
De Simone A,
Cariello A,
Aprile G,
Renne M,
Bonanni B,
DeCensi A</span><br />
<span class="medgenPMjournal">J Clin Oncol</span>
2023 Jun 10;41(17):3116-3121.
Epub 2023 Mar 14
doi: 10.1200/JCO.22.02900.
<span class="bold">PMID: </span><a href="/pubmed/36917758" target="_blank">36917758</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30973790">Randomized Placebo Controlled Trial of Low-Dose Tamoxifen to Prevent Local and Contralateral Recurrence in Breast Intraepithelial Neoplasia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">DeCensi A,
Puntoni M,
Guerrieri-Gonzaga A,
Caviglia S,
Avino F,
Cortesi L,
Taverniti C,
Pacquola MG,
Falcini F,
Gulisano M,
Digennaro M,
Cariello A,
Cagossi K,
Pinotti G,
Lazzeroni M,
Serrano D,
Branchi D,
Campora S,
Petrera M,
Buttiron Webber T,
Boni L,
Bonanni B</span><br />
<span class="medgenPMjournal">J Clin Oncol</span>
2019 Jul 1;37(19):1629-1637.
Epub 2019 Apr 11
doi: 10.1200/JCO.18.01779.
<span class="bold">PMID: </span><a href="/pubmed/30973790" target="_blank">30973790</a><a href="/pmc/articles/PMC6601429" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25551530">Atypical hyperplasia of the breast--risk assessment and management options.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hartmann LC,
Degnim AC,
Santen RJ,
Dupont WD,
Ghosh K</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2015 Jan 1;372(1):78-89.
doi: 10.1056/NEJMsr1407164.
<span class="bold">PMID: </span><a href="/pubmed/25551530" target="_blank">25551530</a><a href="/pmc/articles/PMC4347900" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/17392385">American Cancer Society guidelines for breast screening with MRI as an adjunct to mammography.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Saslow D,
Boetes C,
Burke W,
Harms S,
Leach MO,
Lehman CD,
Morris E,
Pisano E,
Schnall M,
Sener S,
Smith RA,
Warner E,
Yaffe M,
Andrews KS,
Russell CA;
American Cancer Society Breast Cancer Advisory Group</span><br />
<span class="medgenPMjournal">CA Cancer J Clin</span>
2007 Mar-Apr;57(2):75-89.
doi: 10.3322/canjclin.57.2.75.
<span class="bold">PMID: </span><a href="/pubmed/17392385" target="_blank">17392385</a></div>
<div class="nl"><a target="_blank" href="/pubmed/9747868">Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Fisher B,
Costantino JP,
Wickerham DL,
Redmond CK,
Kavanah M,
Cronin WM,
Vogel V,
Robidoux A,
Dimitrov N,
Atkins J,
Daly M,
Wieand S,
Tan-Chiu E,
Ford L,
Wolmark N</span><br />
<span class="medgenPMjournal">J Natl Cancer Inst</span>
1998 Sep 16;90(18):1371-88.
doi: 10.1093/jnci/90.18.1371.
<span class="bold">PMID: </span><a href="/pubmed/9747868" target="_blank">9747868</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Atypical%20hyperplasia%20of%20breast%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (243)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/38061151">European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Rubio IT,
Wyld L,
Marotti L,
Athanasiou A,
Regitnig P,
Catanuto G,
Schoones JW,
Zambon M,
Camps J,
Santini D,
Dietz J,
Sardanelli F,
Varga Z,
Smidt M,
Sharma N,
Shaaban AM,
Gilbert F</span><br />
<span class="medgenPMjournal">Eur J Surg Oncol</span>
2024 Jan;50(1):107292.
Epub 2023 Nov 27
doi: 10.1016/j.ejso.2023.107292.
<span class="bold">PMID: </span><a href="/pubmed/38061151" target="_blank">38061151</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36917758">Randomized Placebo Controlled Trial of Low-Dose Tamoxifen to Prevent Recurrence in Breast Noninvasive Neoplasia: A 10-Year Follow-Up of TAM-01 Study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lazzeroni M,
Puntoni M,
Guerrieri-Gonzaga A,
Serrano D,
Boni L,
Buttiron Webber T,
Fava M,
Briata IM,
Giordano L,
Digennaro M,
Cortesi L,
Falcini F,
Serra P,
Avino F,
Millo F,
Cagossi K,
Gallerani E,
De Simone A,
Cariello A,
Aprile G,
Renne M,
Bonanni B,
DeCensi A</span><br />
<span class="medgenPMjournal">J Clin Oncol</span>
2023 Jun 10;41(17):3116-3121.
Epub 2023 Mar 14
doi: 10.1200/JCO.22.02900.
<span class="bold">PMID: </span><a href="/pubmed/36917758" target="_blank">36917758</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30973790">Randomized Placebo Controlled Trial of Low-Dose Tamoxifen to Prevent Local and Contralateral Recurrence in Breast Intraepithelial Neoplasia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">DeCensi A,
Puntoni M,
Guerrieri-Gonzaga A,
Caviglia S,
Avino F,
Cortesi L,
Taverniti C,
Pacquola MG,
Falcini F,
Gulisano M,
Digennaro M,
Cariello A,
Cagossi K,
Pinotti G,
Lazzeroni M,
Serrano D,
Branchi D,
Campora S,
Petrera M,
Buttiron Webber T,
Boni L,
Bonanni B</span><br />
<span class="medgenPMjournal">J Clin Oncol</span>
2019 Jul 1;37(19):1629-1637.
Epub 2019 Apr 11
doi: 10.1200/JCO.18.01779.
<span class="bold">PMID: </span><a href="/pubmed/30973790" target="_blank">30973790</a><a href="/pmc/articles/PMC6601429" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25551530">Atypical hyperplasia of the breast--risk assessment and management options.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hartmann LC,
Degnim AC,
Santen RJ,
Dupont WD,
Ghosh K</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2015 Jan 1;372(1):78-89.
doi: 10.1056/NEJMsr1407164.
<span class="bold">PMID: </span><a href="/pubmed/25551530" target="_blank">25551530</a><a href="/pmc/articles/PMC4347900" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/9747868">Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Fisher B,
Costantino JP,
Wickerham DL,
Redmond CK,
Kavanah M,
Cronin WM,
Vogel V,
Robidoux A,
Dimitrov N,
Atkins J,
Daly M,
Wieand S,
Tan-Chiu E,
Ford L,
Wolmark N</span><br />
<span class="medgenPMjournal">J Natl Cancer Inst</span>
1998 Sep 16;90(18):1371-88.
doi: 10.1093/jnci/90.18.1371.
<span class="bold">PMID: </span><a href="/pubmed/9747868" target="_blank">9747868</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Atypical%20hyperplasia%20of%20breast%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (680)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/37330436">Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Elfgen C,
Leo C,
Kubik-Huch RA,
Muenst S,
Schmidt N,
Quinn C,
McNally S,
van Diest PJ,
Mann RM,
Bago-Horvath Z,
Bernathova M,
Regitnig P,
Fuchsjäger M,
Schwegler-Guggemos D,
Maranta M,
Zehbe S,
Tausch C,
Güth U,
Fallenberg EM,
Schrading S,
Kothari A,
Sonnenschein M,
Kampmann G,
Kulka J,
Tille JC,
Körner M,
Decker T,
Lax SF,
Daniaux M,
Bjelic-Radisic V,
Kacerovsky-Strobl S,
Condorelli R,
Gnant M,
Varga Z</span><br />
<span class="medgenPMjournal">Virchows Arch</span>
2023 Jul;483(1):5-20.
Epub 2023 Jun 17
doi: 10.1007/s00428-023-03566-x.
<span class="bold">PMID: </span><a href="/pubmed/37330436" target="_blank">37330436</a><a href="/pmc/articles/PMC10326140" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36683493">Inter-observer agreement in the diagnosis of breast atypical ductal hyperplasia: A systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">González Mariño MA</span><br />
<span class="medgenPMjournal">Breast Dis</span>
2022;41(1):545-550.
doi: 10.3233/BD-220029.
<span class="bold">PMID: </span><a href="/pubmed/36683493" target="_blank">36683493</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30131245">Case Report and Review of Adolescent Atypical Ductal Hyperplasia and Juvenile Fibroadenoma: How Do We Assess and Manage Future Risk?</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gandhi S,
Sudheendra P,
Rafferty W,
Loveland-Jones C</span><br />
<span class="medgenPMjournal">Clin Breast Cancer</span>
2018 Oct;18(5):e751-e754.
Epub 2018 Jul 5
doi: 10.1016/j.clbc.2018.07.001.
<span class="bold">PMID: </span><a href="/pubmed/30131245" target="_blank">30131245</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28589368">Reassessing risk models for atypical hyperplasia: age may not matter.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mazzola E,
Coopey SB,
Griffin M,
Polubriaginof F,
Buckley JM,
Parmigiani G,
Garber JE,
Smith BL,
Gadd MA,
Specht MC,
Guidi A,
Hughes KS</span><br />
<span class="medgenPMjournal">Breast Cancer Res Treat</span>
2017 Sep;165(2):285-291.
Epub 2017 Jun 6
doi: 10.1007/s10549-017-4320-7.
<span class="bold">PMID: </span><a href="/pubmed/28589368" target="_blank">28589368</a><a href="/pmc/articles/PMC6214351" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25636589">Breast cancer risk associated with benign breast disease: systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Dyrstad SW,
Yan Y,
Fowler AM,
Colditz GA</span><br />
<span class="medgenPMjournal">Breast Cancer Res Treat</span>
2015 Feb;149(3):569-75.
Epub 2015 Jan 31
doi: 10.1007/s10549-014-3254-6.
<span class="bold">PMID: </span><a href="/pubmed/25636589" target="_blank">25636589</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Atypical%20hyperplasia%20of%20breast%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (670)</a></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="nl"><a target="_blank" href="/pubmed/39270543">Atypical ductal or lobular hyperplasia, lobular carcinoma in-situ, flat epithelial atypia, and future risk of developing breast cancer: Systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Baker J,
Noguchi N,
Marinovich ML,
Sprague BL,
Salisbury E,
Houssami N</span><br />
<span class="medgenPMjournal">Breast</span>
2024 Dec;78:103807.
Epub 2024 Sep 11
doi: 10.1016/j.breast.2024.103807.
<span class="bold">PMID: </span><a href="/pubmed/39270543" target="_blank">39270543</a><a href="/pmc/articles/PMC11415589" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36683493">Inter-observer agreement in the diagnosis of breast atypical ductal hyperplasia: A systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">González Mariño MA</span><br />
<span class="medgenPMjournal">Breast Dis</span>
2022;41(1):545-550.
doi: 10.3233/BD-220029.
<span class="bold">PMID: </span><a href="/pubmed/36683493" target="_blank">36683493</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31660803">Upgrade Rate of Percutaneously Diagnosed Pure Atypical Ductal Hyperplasia: Systematic Review and Meta-Analysis of 6458 Lesions.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Schiaffino S,
Calabrese M,
Melani EF,
Trimboli RM,
Cozzi A,
Carbonaro LA,
Di Leo G,
Sardanelli F</span><br />
<span class="medgenPMjournal">Radiology</span>
2020 Jan;294(1):76-86.
Epub 2019 Oct 29
doi: 10.1148/radiol.2019190748.
<span class="bold">PMID: </span><a href="/pubmed/31660803" target="_blank">31660803</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30521671">Oral and intrauterine progestogens for atypical endometrial hyperplasia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Luo L,
Luo B,
Zheng Y,
Zhang H,
Li J,
Sidell N</span><br />
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
2018 Dec 4;12(12):CD009458.
doi: 10.1002/14651858.CD009458.pub3.
<span class="bold">PMID: </span><a href="/pubmed/30521671" target="_blank">30521671</a><a href="/pmc/articles/PMC6517239" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25636589">Breast cancer risk associated with benign breast disease: systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Dyrstad SW,
Yan Y,
Fowler AM,
Colditz GA</span><br />
<span class="medgenPMjournal">Breast Cancer Res Treat</span>
2015 Feb;149(3):569-75.
Epub 2015 Jan 31
doi: 10.1007/s10549-014-3254-6.
<span class="bold">PMID: </span><a href="/pubmed/25636589" target="_blank">25636589</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Atypical%20hyperplasia%20of%20breast%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (19)</a></div></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(atypical%20hyperplasia%20of%20breast)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Atypical%20hyperplasia%20of%20breast%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<p class="address_footer text-white">National Library of Medicine<br />
<a href="https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323" class="text-white" target="_blank" rel="noopener noreferrer">8600 Rockville Pike<br />
Bethesda, MD 20894</a></p>
</div>
<div class="col-lg-3 col-12 centered-lg">
<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
<a href="https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office" class="text-white">FOIA</a><br />
<a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" class="text-white" id="vdp">HHS Vulnerability Disclosure</a></p>
</div>
<div class="col-lg-3 col-12 centered-lg">
<p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br />
<a href="https://www.nlm.nih.gov/accessibility.html" class="text-white">Accessibility</a><br />
<a href="https://www.nlm.nih.gov/careers/careers.html" class="text-white">Careers</a></p>
</div>
</div>
<div class="row">
<div class="col-lg-12 centered-lg">
<nav class="bottom-links">
<ul class="mt-3">
<li>
<a class="text-white" href="//www.nlm.nih.gov/">NLM</a>
</li>
<li>
<a class="text-white" href="https://www.nih.gov/">NIH</a>
</li>
<li>
<a class="text-white" href="https://www.hhs.gov/">HHS</a>
</li>
<li>
<a class="text-white" href="https://www.usa.gov/">USA.gov</a>
</li>
</ul>
</nav>
</div>
</div>
</div>
</section>
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