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<meta name="keywords" content="C0038868, disease or syndrome, familial progressive supranuclear palsy (type), palsy, progressive supranuclear, progressive supranuclear ophthalmoplegia, progressive supranuclear palsies, progressive supranuclear palsy, psp, psp - progressive supranuclear palsy, psp syndrome, richardson syndrome, richardson's syndrome, steele richardson olszewski disease, steele richardson olszewski syndrome, steele-richardson-olszewski disease, steele-richardson-olszewski syndrome, supranuclear palsies, progressive, supranuclear palsy, progressive, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A rare late-onset neurodegenerative disease with characteristics of supranuclear gaze palsy, postural instability, progressive rigidity, and mild dementia. Five clinical variants have been described with clinicopathological correlations, with Richardson''s syndrome the most common clinical variant. The disease has neuropathological manifestations of neuronal loss, gliosis with astrocytic plaques and accumulation of tau-immunoreactive neurofibrillary tangles in specific brain areas. The differences in the rate and areas of accumulation of phosphorylated tau protein correlate with the five clinical variants. The disease is a 4R tauopathy composed of a preponderance of four-repeat (exon 10 positive) tau isoforms and a characteristic biochemical profile (doublet tau 64 and tau 69). The MAPT H1-clade specific sub-haplotype, H1c, is a risk factor for this disease." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
|
||
UID=21026
|
||
ConceptID=C0038868
|
||
-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Progressive supranuclear palsy</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>21026</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0038868</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>STEELE-RICHARDSON-OLSZEWSKI SYNDROME</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Progressive supranuclear palsy (192976002); PSP - progressive supranuclear palsy (192976002)</td></tr>
|
||
<tr><td>Modes of inheritance:</td>
|
||
<td>
|
||
<div class="divPopper rprt" id="moi_988794"><div><strong>Not genetically inherited</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>988794</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms that cannot be identified in NLM's Unified Medical Language system (UMLS) Click for more information.">CN307044</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Source: Orphanet</div>
|
||
<div class="spaceAbove">clinical entity without genetic inheritance.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/988794">This record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_988794" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Not genetically inherited</a><span> (Orphanet)</span></div></td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help" data-jig="ncbipopper" href="#target-gene-related">Related gene:<img src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div id="target-gene-related" class="display-none">
|
||
Gene(s) associated with related conditions. For conditions<br />
|
||
in a hierarchy, the parent condition will list the genes<br />
|
||
associated with the children conditions.</div></td>
|
||
<td><a target="_blank" href="/gene/4137">MAPT</a></td></tr><tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0019037" target="_blank">MONDO:0019037</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/601104" target="_blank">601104</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span> Phenotypic series:</td>
|
||
<td><a href="https://omim.org/phenotypicSeries/PS601104" target="_blank">PS601104</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=683">ORPHA683</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_100">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">A rare late-onset neurodegenerative disease with characteristics of supranuclear gaze palsy, postural instability, progressive rigidity, and mild dementia. Five clinical variants have been described with clinicopathological correlations, with Richardson''s syndrome the most common clinical variant. The disease has neuropathological manifestations of neuronal loss, gliosis with astrocytic plaques and accumulation of tau-immunoreactive neurofibrillary tangles in specific brain areas. The differences in the rate and areas of accumulation of phosphorylated tau protein correlate with the five clinical variants. The disease is a 4R tauopathy composed of a preponderance of four-repeat (exon 10 positive) tau isoforms and a characteristic biochemical profile (doublet tau 64 and tau 69). The MAPT H1-clade specific sub-haplotype, H1c, is a risk factor for this disease. [from <a title="US Edition of SNOMED CT" href="http://www.nlm.nih.gov/research/umls/Snomed/us_edition.html" class="defSource" target="_blank">SNOMEDCT_US</a>]</div>
|
||
</div>
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||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li><li><a href="#tabORDO">Orphanet</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C4551862[DISCUI]&test_type=Clinical" ref="ncbi_uid=1641556">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=1641556" ref="ncbi_uid=1641556">V</a></span></span><span class="TLline"><a href="/medgen/1641556" ref="tree=GTR&ncbi_uid=1641556&link_uid=1641556" title="View MedGen record for 'Progressive supranuclear ophthalmoplegia'">Progressive supranuclear ophthalmoplegia</a></span><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0038868[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=21026">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=21026" target="_blank" href="/omim/601104">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=21026" ref="ncbi_uid=21026">V</a></span></span><span class="TLline">Progressive supranuclear palsy</span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C4551863[DISCUI]&test_type=Clinical" ref="ncbi_uid=1640811">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=1640811" target="_blank" href="/omim/157140">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1505/" ref="ncbi_uid=1640811">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=1640811" ref="ncbi_uid=1640811">V</a></span></span><span class="TLline"><a href="/medgen/1640811" ref="tree=GTR&ncbi_uid=1640811&link_uid=1640811" title="View MedGen record for 'Supranuclear palsy, progressive, 1'">Supranuclear palsy, progressive, 1</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=324446" target="_blank" href="/omim/609454">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/324446" ref="tree=GTR&ncbi_uid=324446&link_uid=324446" title="View MedGen record for 'Supranuclear palsy, progressive, 2'">Supranuclear palsy, progressive, 2</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=370922" target="_blank" href="/omim/610898">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/370922" ref="tree=GTR&ncbi_uid=370922&link_uid=370922" title="View MedGen record for 'Supranuclear palsy, progressive, 3'">Supranuclear palsy, progressive, 3</a></span></li></ul></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/311052" ref="tree=MeSH" title="MedGen record for Non-Neoplastic Disorder">Non-Neoplastic Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/317955" ref="tree=MeSH" title="MedGen record for Non-Neoplastic Disorder by Special Category">Non-Neoplastic Disorder by Special Category</a></span><ul><li><span class="TLline"><a href="/medgen/224837" ref="tree=MeSH" title="MedGen record for Degenerative disorder">Degenerative disorder</a></span><ul><li><span class="TLline"><a href="/medgen/124363" ref="tree=MeSH" title="MedGen record for Degenerative disease of the central nervous system">Degenerative disease of the central nervous system</a></span><ul><li><span class="matched_ds">Progressive supranuclear palsy</span><ul><li><span class="TLline"><a href="/medgen/1779597" ref="tree=MeSH" title="MedGen record for Atypical progressive supranuclear palsy syndrome">Atypical progressive supranuclear palsy syndrome</a></span></li><li><span class="TLline"><a href="/medgen/1640811" ref="tree=MeSH" title="MedGen record for Supranuclear palsy, progressive, 1">Supranuclear palsy, progressive, 1</a></span></li><li><span class="TLline"><a href="/medgen/324446" ref="tree=MeSH" title="MedGen record for Supranuclear palsy, progressive, 2">Supranuclear palsy, progressive, 2</a></span></li><li><span class="TLline"><a href="/medgen/370922" ref="tree=MeSH" title="MedGen record for Supranuclear palsy, progressive, 3">Supranuclear palsy, progressive, 3</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div><div id="tabORDO">Follow <a target="_blank" href="http://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&data_id=156&PatId=846&search=Disease_Classif_Simple&new=1" class="ital bold">this link</a> to review classifications for <span class="ital">Progressive supranuclear palsy</span> in Orphanet.</div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34215700">Progressive supranuclear palsy: diagnosis and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rowe JB,
|
||
Holland N,
|
||
Rittman T</span><br />
|
||
<span class="medgenPMjournal">Pract Neurol</span>
|
||
2021 Oct;21(5):376-383.
|
||
Epub 2021 Jul 2
|
||
doi: 10.1136/practneurol-2020-002794.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34215700" target="_blank">34215700</a><a href="/pmc/articles/PMC8461411" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32487421">Progressive supranuclear palsy: Advances in diagnosis and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Coughlin DG,
|
||
Litvan I</span><br />
|
||
<span class="medgenPMjournal">Parkinsonism Relat Disord</span>
|
||
2020 Apr;73:105-116.
|
||
Epub 2020 May 25
|
||
doi: 10.1016/j.parkreldis.2020.04.014.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32487421" target="_blank">32487421</a><a href="/pmc/articles/PMC7462164" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28467028">Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Höglinger GU,
|
||
Respondek G,
|
||
Stamelou M,
|
||
Kurz C,
|
||
Josephs KA,
|
||
Lang AE,
|
||
Mollenhauer B,
|
||
Müller U,
|
||
Nilsson C,
|
||
Whitwell JL,
|
||
Arzberger T,
|
||
Englund E,
|
||
Gelpi E,
|
||
Giese A,
|
||
Irwin DJ,
|
||
Meissner WG,
|
||
Pantelyat A,
|
||
Rajput A,
|
||
van Swieten JC,
|
||
Troakes C,
|
||
Antonini A,
|
||
Bhatia KP,
|
||
Bordelon Y,
|
||
Compta Y,
|
||
Corvol JC,
|
||
Colosimo C,
|
||
Dickson DW,
|
||
Dodel R,
|
||
Ferguson L,
|
||
Grossman M,
|
||
Kassubek J,
|
||
Krismer F,
|
||
Levin J,
|
||
Lorenzl S,
|
||
Morris HR,
|
||
Nestor P,
|
||
Oertel WH,
|
||
Poewe W,
|
||
Rabinovici G,
|
||
Rowe JB,
|
||
Schellenberg GD,
|
||
Seppi K,
|
||
van Eimeren T,
|
||
Wenning GK,
|
||
Boxer AL,
|
||
Golbe LI,
|
||
Litvan I;
|
||
Movement Disorder Society-endorsed PSP Study Group</span><br />
|
||
<span class="medgenPMjournal">Mov Disord</span>
|
||
2017 Jun;32(6):853-864.
|
||
Epub 2017 May 3
|
||
doi: 10.1002/mds.26987.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28467028" target="_blank">28467028</a><a href="/pmc/articles/PMC5516529" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22progressive%20supranuclear%20palsy%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (195)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36222770">Progressive Supranuclear Palsy and Corticobasal Syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pantelyat A</span><br />
|
||
<span class="medgenPMjournal">Continuum (Minneap Minn)</span>
|
||
2022 Oct 1;28(5):1364-1378.
|
||
doi: 10.1212/CON.0000000000001158.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36222770" target="_blank">36222770</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34215700">Progressive supranuclear palsy: diagnosis and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rowe JB,
|
||
Holland N,
|
||
Rittman T</span><br />
|
||
<span class="medgenPMjournal">Pract Neurol</span>
|
||
2021 Oct;21(5):376-383.
|
||
Epub 2021 Jul 2
|
||
doi: 10.1136/practneurol-2020-002794.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34215700" target="_blank">34215700</a><a href="/pmc/articles/PMC8461411" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30098799">New classification of tauopathies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Höglinger GU,
|
||
Respondek G,
|
||
Kovacs GG</span><br />
|
||
<span class="medgenPMjournal">Rev Neurol (Paris)</span>
|
||
2018 Nov;174(9):664-668.
|
||
Epub 2018 Aug 8
|
||
doi: 10.1016/j.neurol.2018.07.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30098799" target="_blank">30098799</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28912150">(18)F-FDG PET in Parkinsonism: Differential Diagnosis and Evaluation of Cognitive Impairment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Meyer PT,
|
||
Frings L,
|
||
Rücker G,
|
||
Hellwig S</span><br />
|
||
<span class="medgenPMjournal">J Nucl Med</span>
|
||
2017 Dec;58(12):1888-1898.
|
||
Epub 2017 Sep 14
|
||
doi: 10.2967/jnumed.116.186403.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28912150" target="_blank">28912150</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24963674">Progressive supranuclear palsy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Golbe LI</span><br />
|
||
<span class="medgenPMjournal">Semin Neurol</span>
|
||
2014 Apr;34(2):151-9.
|
||
Epub 2014 Jun 25
|
||
doi: 10.1055/s-0034-1381736.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24963674" target="_blank">24963674</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Progressive%20supranuclear%20palsy%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1652)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36222770">Progressive Supranuclear Palsy and Corticobasal Syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pantelyat A</span><br />
|
||
<span class="medgenPMjournal">Continuum (Minneap Minn)</span>
|
||
2022 Oct 1;28(5):1364-1378.
|
||
doi: 10.1212/CON.0000000000001158.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36222770" target="_blank">36222770</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34215700">Progressive supranuclear palsy: diagnosis and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rowe JB,
|
||
Holland N,
|
||
Rittman T</span><br />
|
||
<span class="medgenPMjournal">Pract Neurol</span>
|
||
2021 Oct;21(5):376-383.
|
||
Epub 2021 Jul 2
|
||
doi: 10.1136/practneurol-2020-002794.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34215700" target="_blank">34215700</a><a href="/pmc/articles/PMC8461411" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32487421">Progressive supranuclear palsy: Advances in diagnosis and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Coughlin DG,
|
||
Litvan I</span><br />
|
||
<span class="medgenPMjournal">Parkinsonism Relat Disord</span>
|
||
2020 Apr;73:105-116.
|
||
Epub 2020 May 25
|
||
doi: 10.1016/j.parkreldis.2020.04.014.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32487421" target="_blank">32487421</a><a href="/pmc/articles/PMC7462164" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31779824">Progressive supranuclear palsy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Giagkou N,
|
||
Höglinger GU,
|
||
Stamelou M</span><br />
|
||
<span class="medgenPMjournal">Int Rev Neurobiol</span>
|
||
2019;149:49-86.
|
||
Epub 2019 Nov 21
|
||
doi: 10.1016/bs.irn.2019.10.013.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31779824" target="_blank">31779824</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29903629">Magnetic resonance imaging in dementia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Raposo Rodríguez L,
|
||
Tovar Salazar DJ,
|
||
Fernández García N,
|
||
Pastor Hernández L,
|
||
Fernández Guinea Ó</span><br />
|
||
<span class="medgenPMjournal">Radiologia (Engl Ed)</span>
|
||
2018 Nov-Dec;60(6):476-484.
|
||
Epub 2018 Jun 11
|
||
doi: 10.1016/j.rx.2018.04.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29903629" target="_blank">29903629</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Progressive%20supranuclear%20palsy%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2373)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36293457">Mitochondrial Dysfunction and Neurodegenerative Disorders: Role of Nutritional Supplementation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mantle D,
|
||
Hargreaves IP</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2022 Oct 20;23(20)
|
||
doi: 10.3390/ijms232012603.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36293457" target="_blank">36293457</a><a href="/pmc/articles/PMC9604531" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29556602">Tau protein in neurodegenerative diseases - a review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pîrşcoveanu DFV,
|
||
Pirici I,
|
||
Tudorică V,
|
||
Bălşeanu TA,
|
||
Albu VC,
|
||
Bondari S,
|
||
Bumbea AM,
|
||
Pîrşcoveanu M</span><br />
|
||
<span class="medgenPMjournal">Rom J Morphol Embryol</span>
|
||
2017;58(4):1141-1150.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29556602" target="_blank">29556602</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28912150">(18)F-FDG PET in Parkinsonism: Differential Diagnosis and Evaluation of Cognitive Impairment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Meyer PT,
|
||
Frings L,
|
||
Rücker G,
|
||
Hellwig S</span><br />
|
||
<span class="medgenPMjournal">J Nucl Med</span>
|
||
2017 Dec;58(12):1888-1898.
|
||
Epub 2017 Sep 14
|
||
doi: 10.2967/jnumed.116.186403.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28912150" target="_blank">28912150</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26459661">Interventions in progressive supranuclear palsy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Koros C,
|
||
Stamelou M</span><br />
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<div class="nl"><a target="_blank" href="/pubmed/4647151">Progressive supranuclear palsy.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Steele JC</span><br />
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1972;95(4):693-704.
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<span class="bold">PMID: </span><a href="/pubmed/4647151" target="_blank">4647151</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/36222770">Progressive Supranuclear Palsy and Corticobasal Syndrome.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Pantelyat A</span><br />
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<div class="portlet_content ln"><span class="medgenPMauthor">Raposo Rodríguez L,
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Tovar Salazar DJ,
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2018 Nov-Dec;60(6):476-484.
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doi: 10.1016/j.rx.2018.04.003.
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<span class="bold">PMID: </span><a href="/pubmed/29903629" target="_blank">29903629</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/28912150">(18)F-FDG PET in Parkinsonism: Differential Diagnosis and Evaluation of Cognitive Impairment.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Meyer PT,
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<div class="nl"><a target="_blank" href="/pubmed/28467028">Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria.</a></div>
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Irwin DJ,
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Meissner WG,
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Pantelyat A,
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Rajput A,
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van Swieten JC,
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Troakes C,
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Antonini A,
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Bhatia KP,
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Bordelon Y,
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Compta Y,
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Corvol JC,
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Colosimo C,
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Dickson DW,
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Dodel R,
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Ferguson L,
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Krismer F,
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Levin J,
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Lorenzl S,
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Morris HR,
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Nestor P,
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Rowe JB,
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Boxer AL,
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Golbe LI,
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Litvan I;
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Progressive%20supranuclear%20palsy%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (753)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/40039207">The longitudinal study of morphometric measurement changes in progressive supranuclear palsy.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Ling R,
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<span class="medgenPMjournal">Annu Int Conf IEEE Eng Med Biol Soc</span>
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<span class="bold">PMID: </span><a href="/pubmed/40039207" target="_blank">40039207</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/34511151">Clinical Significance of Applause Sign in Patients with Progressive Supranuclear Palsy.</a></div>
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Basu P,
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<div class="nl"><a target="_blank" href="/pubmed/29903629">Magnetic resonance imaging in dementia.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Raposo Rodríguez L,
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Tovar Salazar DJ,
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Fernández García N,
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Pastor Hernández L,
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Fernández Guinea Ó</span><br />
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<span class="medgenPMjournal">Radiologia (Engl Ed)</span>
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2018 Nov-Dec;60(6):476-484.
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Epub 2018 Jun 11
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doi: 10.1016/j.rx.2018.04.003.
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<span class="bold">PMID: </span><a href="/pubmed/29903629" target="_blank">29903629</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/12548345">Frequency, distribution and characteristics of progressive supranuclear palsy in Italy: preliminary observations.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/3315157">Progressive supranuclear palsy.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Duvoisin RC,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Progressive%20supranuclear%20palsy%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1397)</a></div></div>
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|
||
<div class="nl"><a target="_blank" href="/pubmed/36633672">Tau PET imaging in progressive supranuclear palsy: a systematic review and meta-analysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Jin J,
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Su D,
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Zhang J,
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Li X,
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Feng T</span><br />
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2023 May;270(5):2451-2467.
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||
Epub 2023 Jan 12
|
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doi: 10.1007/s00415-022-11556-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36633672" target="_blank">36633672</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33567955">A Systematic Review of Apathy and Depression in Progressive Supranuclear Palsy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Flavell J,
|
||
Nestor PJ</span><br />
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<span class="medgenPMjournal">J Geriatr Psychiatry Neurol</span>
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2022 May;35(3):280-292.
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Epub 2021 Feb 11
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||
doi: 10.1177/0891988721993545.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33567955" target="_blank">33567955</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31752626">The Progressive Supranuclear Palsy: Past and Present Aspects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Parthimos TP,
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||
Schulpis KH</span><br />
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<span class="medgenPMjournal">Clin Gerontol</span>
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||
2020 Mar-Apr;43(2):155-180.
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Epub 2019 Nov 22
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doi: 10.1080/07317115.2019.1694115.
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||
<span class="bold">PMID: </span><a href="/pubmed/31752626" target="_blank">31752626</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31783740">Exercise and Progressive Supranuclear Palsy: the need for explicit exercise reporting.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Slade SC,
|
||
Underwood M,
|
||
McGinley JL,
|
||
Morris ME</span><br />
|
||
<span class="medgenPMjournal">BMC Neurol</span>
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||
2019 Nov 29;19(1):305.
|
||
doi: 10.1186/s12883-019-1539-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31783740" target="_blank">31783740</a><a href="/pmc/articles/PMC6884751" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27070344">Progressive supranuclear palsy (PSP): Richardson syndrome and other PSP variants.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lopez G,
|
||
Bayulkem K,
|
||
Hallett M</span><br />
|
||
<span class="medgenPMjournal">Acta Neurol Scand</span>
|
||
2016 Oct;134(4):242-9.
|
||
Epub 2016 Jan 6
|
||
doi: 10.1111/ane.12546.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27070344" target="_blank">27070344</a><a href="/pmc/articles/PMC7292631" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Progressive%20supranuclear%20palsy%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (53)</a></div></div>
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<div class="portlet_content ln"><ul><li><a href="https://www.malacards.org/card/supranuclear_palsy_progressive_1" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Progressive%20supranuclear%20palsy" target="_blank">MedlinePlus</a></li><li><a href="https://rarediseases.info.nih.gov/diseases/7471/disease" target="_blank">NCATS Office of Rare Diseases Research (GARD)</a></li></ul></div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67d4a15fcde49f3df7004059">Table B. [OMIM Entries for MAPT-Related Frontotemporal Dementia (View All in OMI...</a>
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<div class="ralinkpop offscreen_noflow">Table B. [OMIM Entries for MAPT-Related Frontotemporal Dementia (View All in OMIM)]. - GeneReviews®<div class="brieflinkpopdesc"></div></div>
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<div class="ralinkpop offscreen_noflow">RecName: Full=Microtubule-associated protein tau; AltName: Full=Neurofibrillary tangle protein; AltName: Full=Paired helical filament-tau; Short=PHF-tau<div class="brieflinkpopdesc">gi|334302961|sp|P10636.5|TAU_HUMAN</div></div>
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