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<meta name="keywords" content="C0036974, acute circulatory failure, circulatory collapse, circulatory failure, collapse, circulatory, failure, circulatory, pathologic function, peripheral circulatory failure, peripheral vascular failure, peripheral vascular shutdown, shock, shock - physiological, vascular collapse, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="The state in which profound and widespread reduction of effective tissue perfusion leads first to reversible, and then if prolonged, to irreversible cellular injury." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
UID=20738
ConceptID=C0036974
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Shock</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>20738</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0036974</a></dd><dt><span class="dotprefix"></span></dt><dd>Pathologic Function</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Circulatory Collapse; Circulatory Failure; Collapse, Circulatory; Failure, Circulatory</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Shock (27942005); Circulatory collapse (27942005); Peripheral vascular shutdown (27942005); Peripheral circulatory failure (27942005); Peripheral vascular failure (27942005); Acute circulatory failure (27942005); Shock - physiological (27942005)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0031273">HP:0031273</a></td></tr>
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">The state in which profound and widespread reduction of effective tissue perfusion leads first to reversible, and then if prolonged, to irreversible cellular injury. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Shock</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/2848" ref="tree=MeSH" title="MedGen record for Disorder of cardiovascular system">Disorder of cardiovascular system</a></span><ul><li><span class="TLline"><a href="/medgen/116727" ref="tree=MeSH" title="MedGen record for Abnormality of the cardiovascular system">Abnormality of the cardiovascular system</a></span><ul><li><span class="TLline"><a href="/medgen/869166" ref="tree=MeSH" title="MedGen record for Abnormal cardiovascular system physiology">Abnormal cardiovascular system physiology</a></span><ul><li><span class="matched_ds">Shock</span><ul><li><span class="TLline"><a href="/medgen/1373755" ref="tree=MeSH" title="MedGen record for Anaphylactic shock">Anaphylactic shock</a></span><ul><li><span class="TLline"><a href="/medgen/576123" ref="tree=MeSH" title="MedGen record for Drug-induced anaphylaxis">Drug-induced anaphylaxis</a></span></li><li><span class="TLline"><a href="/medgen/576137" ref="tree=MeSH" title="MedGen record for Exercise induced anaphylaxis">Exercise induced anaphylaxis</a></span></li><li><span class="TLline"><a href="/medgen/672819" ref="tree=MeSH" title="MedGen record for Food-induced anaphylaxis">Food-induced anaphylaxis</a></span></li><li><span class="TLline"><a href="/medgen/595022" ref="tree=MeSH" title="MedGen record for Idiopathic anaphylaxis">Idiopathic anaphylaxis</a></span></li><li><span class="TLline"><a href="/medgen/576116" ref="tree=MeSH" title="MedGen record for Venom-induced anaphylaxis">Venom-induced anaphylaxis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/48650" ref="tree=MeSH" title="MedGen record for Cardiogenic shock">Cardiogenic shock</a></span></li><li><span class="TLline"><a href="/medgen/1612211" ref="tree=MeSH" title="MedGen record for Distributive shock">Distributive shock</a></span></li><li><span class="TLline"><a href="/medgen/11409" ref="tree=MeSH" title="MedGen record for Hemorrhagic shock">Hemorrhagic shock</a></span></li><li><span class="TLline"><a href="/medgen/1789315" ref="tree=MeSH" title="MedGen record for Hypotensive Shock">Hypotensive Shock</a></span></li><li><span class="TLline"><a href="/medgen/5722" ref="tree=MeSH" title="MedGen record for Hypovolemic shock">Hypovolemic shock</a></span></li><li><span class="TLline"><a href="/medgen/279666" ref="tree=MeSH" title="MedGen record for Insulin Shock">Insulin Shock</a></span></li><li><span class="TLline"><a href="/medgen/822261" ref="tree=MeSH" title="MedGen record for Intrapartum Shock">Intrapartum Shock</a></span></li><li><span class="TLline"><a href="/medgen/6462" ref="tree=MeSH" title="MedGen record for Multiple organ dysfunction syndrome">Multiple organ dysfunction syndrome</a></span></li><li><span class="TLline"><a href="/medgen/107781" ref="tree=MeSH" title="MedGen record for Neurogenic shock">Neurogenic shock</a></span></li><li><span class="TLline"><a href="/medgen/1621062" ref="tree=MeSH" title="MedGen record for Obstructive shock">Obstructive shock</a></span></li><li><span class="TLline"><a href="/medgen/821252" ref="tree=MeSH" title="MedGen record for Postpartum Shock">Postpartum Shock</a></span></li><li><span class="TLline"><a href="/medgen/11410" ref="tree=MeSH" title="MedGen record for Septic shock">Septic shock</a></span></li><li><span class="TLline"><a href="/medgen/407976" ref="tree=MeSH" title="MedGen record for Shock From Lead">Shock From Lead</a></span></li><li><span class="TLline"><a href="/medgen/11411" ref="tree=MeSH" title="MedGen record for Surgical Shock">Surgical Shock</a></span><ul><li><span class="TLline"><a href="/medgen/46040" ref="tree=MeSH" title="MedGen record for Postoperative shock">Postoperative shock</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/69303" ref="tree=MeSH" title="MedGen record for Systemic inflammatory response syndrome">Systemic inflammatory response syndrome</a></span><ul><li><span class="TLline"><a href="/medgen/215297" ref="tree=MeSH" title="MedGen record for Cytokine release syndrome">Cytokine release syndrome</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/19964" ref="tree=MeSH" title="MedGen record for Traumatic shock">Traumatic shock</a></span><ul><li><span class="TLline"><a href="/medgen/3671" ref="tree=MeSH" title="MedGen record for Crush syndrome">Crush syndrome</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_815866"><div><strong>Catecholaminergic polymorphic ventricular tachycardia 5</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>815866</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3809536</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Catecholaminergic polymorphic ventricular tachycardia (CPVT) is characterized by episodic syncope occurring during exercise or acute emotion. The underlying cause of these episodes is the onset of fast ventricular tachycardia (bidirectional or polymorphic). Spontaneous recovery may occur when these arrhythmias self-terminate. In other instances, ventricular tachycardia may degenerate into ventricular fibrillation and cause sudden death if cardiopulmonary resuscitation is not readily available. The mean onset of symptoms (usually a syncopal episode) is between age seven and 12 years; onset as late as the fourth decade of life has been reported. If untreated, CPVT is highly lethal, as approximately 30% of affected individuals experience at least one cardiac arrest and up to 80% have one or more syncopal spells. Sudden death may be the first manifestation of the disease.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/815866">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_815866" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Catecholaminergic polymorphic ventricular tachycardia 5</a></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/38245889">International Consensus Criteria for Pediatric Sepsis and Septic Shock.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Schlapbach LJ,
Watson RS,
Sorce LR,
Argent AC,
Menon K,
Hall MW,
Akech S,
Albers DJ,
Alpern ER,
Balamuth F,
Bembea M,
Biban P,
Carrol ED,
Chiotos K,
Chisti MJ,
DeWitt PE,
Evans I,
Flauzino de Oliveira C,
Horvat CM,
Inwald D,
Ishimine P,
Jaramillo-Bustamante JC,
Levin M,
Lodha R,
Martin B,
Nadel S,
Nakagawa S,
Peters MJ,
Randolph AG,
Ranjit S,
Rebull MN,
Russell S,
Scott HF,
de Souza DC,
Tissieres P,
Weiss SL,
Wiens MO,
Wynn JL,
Kissoon N,
Zimmerman JJ,
Sanchez-Pinto LN,
Bennett TD;
Society of Critical Care Medicine Pediatric Sepsis Definition Task Force</span><br />
<span class="medgenPMjournal">JAMA</span>
2024 Feb 27;331(8):665-674.
doi: 10.1001/jama.2024.0179.
<span class="bold">PMID: </span><a href="/pubmed/38245889" target="_blank">38245889</a><a href="/pmc/articles/PMC10900966" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35379503">2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Heidenreich PA,
Bozkurt B,
Aguilar D,
Allen LA,
Byun JJ,
Colvin MM,
Deswal A,
Drazner MH,
Dunlay SM,
Evers LR,
Fang JC,
Fedson SE,
Fonarow GC,
Hayek SS,
Hernandez AF,
Khazanie P,
Kittleson MM,
Lee CS,
Link MS,
Milano CA,
Nnacheta LC,
Sandhu AT,
Stevenson LW,
Vardeny O,
Vest AR,
Yancy CW</span><br />
<span class="medgenPMjournal">J Am Coll Cardiol</span>
2022 May 3;79(17):e263-e421.
Epub 2022 Apr 1
doi: 10.1016/j.jacc.2021.12.012.
<span class="bold">PMID: </span><a href="/pubmed/35379503" target="_blank">35379503</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35363499">2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Heidenreich PA,
Bozkurt B,
Aguilar D,
Allen LA,
Byun JJ,
Colvin MM,
Deswal A,
Drazner MH,
Dunlay SM,
Evers LR,
Fang JC,
Fedson SE,
Fonarow GC,
Hayek SS,
Hernandez AF,
Khazanie P,
Kittleson MM,
Lee CS,
Link MS,
Milano CA,
Nnacheta LC,
Sandhu AT,
Stevenson LW,
Vardeny O,
Vest AR,
Yancy CW;
ACC/AHA Joint Committee Members</span><br />
<span class="medgenPMjournal">Circulation</span>
2022 May 3;145(18):e895-e1032.
Epub 2022 Apr 1
doi: 10.1161/CIR.0000000000001063.
<span class="bold">PMID: </span><a href="/pubmed/35363499" target="_blank">35363499</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22shock%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (6156)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/35912478">Acute valvular emergencies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bernard S,
Deferm S,
Bertrand PB</span><br />
<span class="medgenPMjournal">Eur Heart J Acute Cardiovasc Care</span>
2022 Aug 9;11(8):653-665.
doi: 10.1093/ehjacc/zuac086.
<span class="bold">PMID: </span><a href="/pubmed/35912478" target="_blank">35912478</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33642170">ECPella: Concept, Physiology and Clinical Applications.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Meani P,
Lorusso R,
Pappalardo F</span><br />
<span class="medgenPMjournal">J Cardiothorac Vasc Anesth</span>
2022 Feb;36(2):557-566.
Epub 2021 Feb 6
doi: 10.1053/j.jvca.2021.01.056.
<span class="bold">PMID: </span><a href="/pubmed/33642170" target="_blank">33642170</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31843507">Septic shock in pediatrics: the state-of-the-art.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Garcia PCR,
Tonial CT,
Piva JP</span><br />
<span class="medgenPMjournal">J Pediatr (Rio J)</span>
2020 Mar-Apr;96 Suppl 1(Suppl 1):87-98.
Epub 2019 Dec 13
doi: 10.1016/j.jped.2019.10.007.
<span class="bold">PMID: </span><a href="/pubmed/31843507" target="_blank">31843507</a><a href="/pmc/articles/PMC9432279" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24996603">Cardiogenic shock.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Shah P,
Cowger JA</span><br />
<span class="medgenPMjournal">Crit Care Clin</span>
2014 Jul;30(3):391-412.
doi: 10.1016/j.ccc.2014.03.001.
<span class="bold">PMID: </span><a href="/pubmed/24996603" target="_blank">24996603</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23984731">Severe sepsis and septic shock.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Angus DC,
van der Poll T</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2013 Aug 29;369(9):840-51.
doi: 10.1056/NEJMra1208623.
<span class="bold">PMID: </span><a href="/pubmed/23984731" target="_blank">23984731</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Shock%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (47126)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/38003374">Endotoxic Septic Shock: Diagnosis and Treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Foster DM,
Kellum JA</span><br />
<span class="medgenPMjournal">Int J Mol Sci</span>
2023 Nov 10;24(22)
doi: 10.3390/ijms242216185.
<span class="bold">PMID: </span><a href="/pubmed/38003374" target="_blank">38003374</a><a href="/pmc/articles/PMC10671446" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36304809">SEPSIS DEFINITION: WHAT'S NEW IN THE TREATMENT GUIDELINES.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Srzić I,
Nesek Adam V,
Tunjić Pejak D</span><br />
<span class="medgenPMjournal">Acta Clin Croat</span>
2022 Jun;61(Suppl 1):67-72.
doi: 10.20471/acc.2022.61.s1.11.
<span class="bold">PMID: </span><a href="/pubmed/36304809" target="_blank">36304809</a><a href="/pmc/articles/PMC9536156" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30573009">The Nomenclature, Definition and Distinction of Types of Shock.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Standl T,
Annecke T,
Cascorbi I,
Heller AR,
Sabashnikov A,
Teske W</span><br />
<span class="medgenPMjournal">Dtsch Arztebl Int</span>
2018 Nov 9;115(45):757-768.
doi: 10.3238/arztebl.2018.0757.
<span class="bold">PMID: </span><a href="/pubmed/30573009" target="_blank">30573009</a><a href="/pmc/articles/PMC6323133" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27894494">Optimal Fluid Therapy for Traumatic Hemorrhagic Shock.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chang R,
Holcomb JB</span><br />
<span class="medgenPMjournal">Crit Care Clin</span>
2017 Jan;33(1):15-36.
doi: 10.1016/j.ccc.2016.08.007.
<span class="bold">PMID: </span><a href="/pubmed/27894494" target="_blank">27894494</a><a href="/pmc/articles/PMC5131713" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25441032">Shock.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wacker DA,
Winters ME</span><br />
<span class="medgenPMjournal">Emerg Med Clin North Am</span>
2014 Nov;32(4):747-58.
Epub 2014 Aug 28
doi: 10.1016/j.emc.2014.07.003.
<span class="bold">PMID: </span><a href="/pubmed/25441032" target="_blank">25441032</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Shock%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (34050)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/37880041">Methylene Blue Reduces Mortality in Critically Ill and Perioperative Patients: A Meta-Analysis of Randomized Trials.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pruna A,
Bonaccorso A,
Belletti A,
Turi S,
Di Prima AL,
D'amico F,
Zangrillo A,
Kotani Y,
Landoni G</span><br />
<span class="medgenPMjournal">J Cardiothorac Vasc Anesth</span>
2024 Jan;38(1):268-274.
Epub 2023 Oct 1
doi: 10.1053/j.jvca.2023.09.037.
<span class="bold">PMID: </span><a href="/pubmed/37880041" target="_blank">37880041</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37078161">Different Concentrations of Albumin Versus Crystalloid in Patients with Sepsis and Septic Shock: A Meta-Analysis of Randomized Clinical Trials.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Geng L,
Tian X,
Gao Z,
Mao A,
Feng L,
He C</span><br />
<span class="medgenPMjournal">J Intensive Care Med</span>
2023 Aug;38(8):679-689.
Epub 2023 Apr 20
doi: 10.1177/08850666231170778.
<span class="bold">PMID: </span><a href="/pubmed/37078161" target="_blank">37078161</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34038642">Extracorporeal shock wave therapy on pain and foot functions in subjects with chronic plantar fasciitis: systematic review of randomized controlled trials.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Melese H,
Alamer A,
Getie K,
Nigussie F,
Ayhualem S</span><br />
<span class="medgenPMjournal">Disabil Rehabil</span>
2022 Sep;44(18):5007-5014.
Epub 2021 May 26
doi: 10.1080/09638288.2021.1928775.
<span class="bold">PMID: </span><a href="/pubmed/34038642" target="_blank">34038642</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31775846">The SOFA score-development, utility and challenges of accurate assessment in clinical trials.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lambden S,
Laterre PF,
Levy MM,
Francois B</span><br />
<span class="medgenPMjournal">Crit Care</span>
2019 Nov 27;23(1):374.
doi: 10.1186/s13054-019-2663-7.
<span class="bold">PMID: </span><a href="/pubmed/31775846" target="_blank">31775846</a><a href="/pmc/articles/PMC6880479" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/16464565">Therapeutic cancer vaccines.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Srivastava PK</span><br />
<span class="medgenPMjournal">Curr Opin Immunol</span>
2006 Apr;18(2):201-5.
Epub 2006 Feb 7
doi: 10.1016/j.coi.2006.01.009.
<span class="bold">PMID: </span><a href="/pubmed/16464565" target="_blank">16464565</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Shock%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (38848)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/35275890">The landscape of cardiogenic shock: epidemiology and current definitions.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Palacios Ordonez C,
Garan AR</span><br />
<span class="medgenPMjournal">Curr Opin Cardiol</span>
2022 May 1;37(3):236-240.
Epub 2022 Mar 11
doi: 10.1097/HCO.0000000000000957.
<span class="bold">PMID: </span><a href="/pubmed/35275890" target="_blank">35275890</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31180939">Precardiogenic Shock: A New Clinical Entity.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Singh T,
Samson R,
Ayinapudi K,
Motwani A,
Le Jemtel TH</span><br />
<span class="medgenPMjournal">Cardiol Rev</span>
2019 Jul/Aug;27(4):198-201.
doi: 10.1097/CRD.0000000000000237.
<span class="bold">PMID: </span><a href="/pubmed/31180939" target="_blank">31180939</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28903154">Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Rhee C,
Dantes R,
Epstein L,
Murphy DJ,
Seymour CW,
Iwashyna TJ,
Kadri SS,
Angus DC,
Danner RL,
Fiore AE,
Jernigan JA,
Martin GS,
Septimus E,
Warren DK,
Karcz A,
Chan C,
Menchaca JT,
Wang R,
Gruber S,
Klompas M;
CDC Prevention Epicenter Program</span><br />
<span class="medgenPMjournal">JAMA</span>
2017 Oct 3;318(13):1241-1249.
doi: 10.1001/jama.2017.13836.
<span class="bold">PMID: </span><a href="/pubmed/28903154" target="_blank">28903154</a><a href="/pmc/articles/PMC5710396" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/16424713">Sepsis in European intensive care units: results of the SOAP study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Vincent JL,
Sakr Y,
Sprung CL,
Ranieri VM,
Reinhart K,
Gerlach H,
Moreno R,
Carlet J,
Le Gall JR,
Payen D;
Sepsis Occurrence in Acutely Ill Patients Investigators</span><br />
<span class="medgenPMjournal">Crit Care Med</span>
2006 Feb;34(2):344-53.
doi: 10.1097/01.ccm.0000194725.48928.3a.
<span class="bold">PMID: </span><a href="/pubmed/16424713" target="_blank">16424713</a></div>
<div class="nl"><a target="_blank" href="/pubmed/8867538">Kawasaki disease.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Jacobs JC</span><br />
<span class="medgenPMjournal">Curr Opin Rheumatol</span>
1996 Jan;8(1):41-3.
doi: 10.1097/00002281-199601000-00007.
<span class="bold">PMID: </span><a href="/pubmed/8867538" target="_blank">8867538</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Shock%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (32182)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/38936757">The premise, promise, and perils of artificial intelligence in critical care cardiology.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Huerta N,
Rao SJ,
Isath A,
Wang Z,
Glicksberg BS,
Krittanawong C</span><br />
<span class="medgenPMjournal">Prog Cardiovasc Dis</span>
2024 Sep-Oct;86:2-12.
Epub 2024 Jun 25
doi: 10.1016/j.pcad.2024.06.006.
<span class="bold">PMID: </span><a href="/pubmed/38936757" target="_blank">38936757</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32280412">Pathophysiology and Advanced Hemodynamic Assessment of Cardiogenic Shock.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Brener MI,
Rosenblum HR,
Burkhoff D</span><br />
<span class="medgenPMjournal">Methodist Debakey Cardiovasc J</span>
2020 Jan-Mar;16(1):7-15.
doi: 10.14797/mdcj-16-1-7.
<span class="bold">PMID: </span><a href="/pubmed/32280412" target="_blank">32280412</a><a href="/pmc/articles/PMC7137617" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28365648">Passive Leg-Raising and Prediction of Fluid Responsiveness: Systematic Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pickett JD,
Bridges E,
Kritek PA,
Whitney JD</span><br />
<span class="medgenPMjournal">Crit Care Nurse</span>
2017 Apr;37(2):32-47.
doi: 10.4037/ccn2017205.
<span class="bold">PMID: </span><a href="/pubmed/28365648" target="_blank">28365648</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26318710">EAU Guidelines on Diagnosis and Conservative Management of Urolithiasis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Türk C,
Petřík A,
Sarica K,
Seitz C,
Skolarikos A,
Straub M,
Knoll T</span><br />
<span class="medgenPMjournal">Eur Urol</span>
2016 Mar;69(3):468-74.
Epub 2015 Aug 28
doi: 10.1016/j.eururo.2015.07.040.
<span class="bold">PMID: </span><a href="/pubmed/26318710" target="_blank">26318710</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21373821">Mottling score predicts survival in septic shock.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ait-Oufella H,
Lemoinne S,
Boelle PY,
Galbois A,
Baudel JL,
Lemant J,
Joffre J,
Margetis D,
Guidet B,
Maury E,
Offenstadt G</span><br />
<span class="medgenPMjournal">Intensive Care Med</span>
2011 May;37(5):801-7.
Epub 2011 Mar 4
doi: 10.1007/s00134-011-2163-y.
<span class="bold">PMID: </span><a href="/pubmed/21373821" target="_blank">21373821</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Shock%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (35134)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_104">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/38864162">Prolonged vs Intermittent Infusions of β-Lactam Antibiotics in Adults With Sepsis or Septic Shock: A Systematic Review and Meta-Analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Abdul-Aziz MH,
Hammond NE,
Brett SJ,
Cotta MO,
De Waele JJ,
Devaux A,
Di Tanna GL,
Dulhunty JM,
Elkady H,
Eriksson L,
Hasan MS,
Khan AB,
Lipman J,
Liu X,
Monti G,
Myburgh J,
Novy E,
Omar S,
Rajbhandari D,
Roger C,
Sjövall F,
Zaghi I,
Zangrillo A,
Delaney A,
Roberts JA</span><br />
<span class="medgenPMjournal">JAMA</span>
2024 Aug 27;332(8):638-648.
doi: 10.1001/jama.2024.9803.
<span class="bold">PMID: </span><a href="/pubmed/38864162" target="_blank">38864162</a><a href="/pmc/articles/PMC11170459" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37231510">Diagnostic accuracy of point-of-care ultrasound for shock: a systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yoshida T,
Yoshida T,
Noma H,
Nomura T,
Suzuki A,
Mihara T</span><br />
<span class="medgenPMjournal">Crit Care</span>
2023 May 25;27(1):200.
doi: 10.1186/s13054-023-04495-6.
<span class="bold">PMID: </span><a href="/pubmed/37231510" target="_blank">37231510</a><a href="/pmc/articles/PMC10214599" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29788397">Polyspecific Intravenous Immunoglobulin in Clindamycin-treated Patients With Streptococcal Toxic Shock Syndrome: A Systematic Review and Meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Parks T,
Wilson C,
Curtis N,
Norrby-Teglund A,
Sriskandan S</span><br />
<span class="medgenPMjournal">Clin Infect Dis</span>
2018 Oct 15;67(9):1434-1436.
doi: 10.1093/cid/ciy401.
<span class="bold">PMID: </span><a href="/pubmed/29788397" target="_blank">29788397</a><a href="/pmc/articles/PMC6186853" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26903336">Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Shankar-Hari M,
Phillips GS,
Levy ML,
Seymour CW,
Liu VX,
Deutschman CS,
Angus DC,
Rubenfeld GD,
Singer M;
Sepsis Definitions Task Force</span><br />
<span class="medgenPMjournal">JAMA</span>
2016 Feb 23;315(8):775-87.
doi: 10.1001/jama.2016.0289.
<span class="bold">PMID: </span><a href="/pubmed/26903336" target="_blank">26903336</a><a href="/pmc/articles/PMC4910392" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21708051">Tennis elbow.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bisset L,
Coombes B,
Vicenzino B</span><br />
<span class="medgenPMjournal">BMJ Clin Evid</span>
2011 Jun 27;2011
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22shock%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Shock%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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