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<meta name="keywords" content="C0034072, cardiopulmonary disease, cor pulmonale, disease or syndrome, disease, pulmonary heart, diseases, pulmonary heart, heart disease, pulmonary, heart diseases, pulmonary, pulmonary heart disease, pulmonary heart disease, unspecified, pulmonary heart diseases, right heart failure due to pulmonary hypertension, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Right-sided heart failure resulting from chronic hypertension in the pulmonary arteries and right ventricle." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
UID=18765
ConceptID=C0034072
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Cor pulmonale</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>18765</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0034072</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Cor Pulmonale; Disease, Pulmonary Heart; Diseases, Pulmonary Heart; Heart Disease, Pulmonary; Heart Diseases, Pulmonary; Pulmonary Heart Disease; Pulmonary Heart Diseases</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Cor pulmonale (83291003); Pulmonary heart disease (83291003); Right heart failure due to pulmonary hypertension (83291003)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0001648">HP:0001648</a></td></tr>
<tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0004596" target="_blank">MONDO:0004596</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">Right-sided heart failure resulting from chronic hypertension in the pulmonary arteries and right ventricle. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Cor pulmonale</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/2848" ref="tree=MeSH" title="MedGen record for Disorder of cardiovascular system">Disorder of cardiovascular system</a></span><ul><li><span class="TLline"><a href="/medgen/116727" ref="tree=MeSH" title="MedGen record for Abnormality of the cardiovascular system">Abnormality of the cardiovascular system</a></span><ul><li><span class="TLline"><a href="/medgen/892473" ref="tree=MeSH" title="MedGen record for Abnormal cardiovascular system morphology">Abnormal cardiovascular system morphology</a></span><ul><li><span class="TLline"><a href="/medgen/6748" ref="tree=MeSH" title="MedGen record for Abnormal heart morphology">Abnormal heart morphology</a></span><ul><li><span class="TLline"><a href="/medgen/871266" ref="tree=MeSH" title="MedGen record for Abnormal cardiac ventricle morphology">Abnormal cardiac ventricle morphology</a></span><ul><li><span class="TLline"><a href="/medgen/91036" ref="tree=MeSH" title="MedGen record for Abnormal right ventricle morphology">Abnormal right ventricle morphology</a></span><ul><li><span class="matched_ds">Cor pulmonale</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_41393"><div><strong>Cystic fibrosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>41393</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0010674</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Cystic fibrosis (CF) is a multisystem disease affecting epithelia of the respiratory tract, exocrine pancreas, intestine, hepatobiliary system, and exocrine sweat glands. Morbidities include recurrent sinusitis and bronchitis, progressive obstructive pulmonary disease with bronchiectasis, exocrine pancreatic deficiency and malnutrition, pancreatitis, gastrointestinal manifestations (meconium ileus, rectal prolapse, distal intestinal obstructive syndrome), liver disease, diabetes, male infertility due to hypoplasia or aplasia of the vas deferens, and reduced fertility or infertility in some women. Pulmonary disease is the major cause of morbidity and mortality in CF.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/41393">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_19310"><div><strong>Isolated Pierre-Robin syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>19310</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0031900</a></dd><dt><span class="dotprefix"></span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
<div class="spaceAbove">Pierre Robin sequence is a craniofacial anomaly comprising mandibular hypoplasia, cleft secondary palate, and glossoptosis leading to life-threatening obstructive apnea and feeding difficulties during the neonatal period (summary by Tan et al., 2013).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/19310">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_65123"><div><strong>X-linked agammaglobulinemia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>65123</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0221026</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">X-linked agammaglobulinemia (XLA) is characterized by recurrent bacterial infections in affected males in the first two years of life. Recurrent otitis is the most common infection prior to diagnosis. Conjunctivitis, sinopulmonary infections, diarrhea, and skin infections are also frequently seen. Approximately 60% of individuals with XLA are recognized as having immunodeficiency when they develop a severe, life-threatening infection such as pneumonia, empyema, meningitis, sepsis, cellulitis, or septic arthritis. S pneumoniae and H influenzae are the most common organisms found prior to diagnosis and may continue to cause sinusitis and otitis after diagnosis and the initiation of gammaglobulin substitution therapy. Severe, difficult-to-treat enteroviral infections (often manifesting as dermatomyositis or chronic meningoencephalitis) can be prevented by this treatment. The prognosis for individuals with XLA has improved markedly in the last 25 years as a result of earlier diagnosis, the development of preparations of gammaglobulin that allow normal concentrations of serum immunoglobulin G to be achieved, and more liberal use of antibiotics.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/65123">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_65962"><div><strong>Desquamative interstitial pneumonia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>65962</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0238378</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Interstitial lung disease (ILD), or pneumonitis, is a heterogeneous group of disorders characterized pathologically by expansion of the interstitial compartment of the lung by inflammatory cells. Fibrosis occurs in many cases (Visscher and Myers, 2006). See also interstitial lung disease-1 (ILD1; 619611).&#13; Desquamative interstitial pneumonitis (DIP) was originally described as a pathologic entity by Liebow et al. (1965). Lung biopsy shows diffuse and uniform filling of alveoli by clusters of cells which Liebow et al. (1965) speculated to be 'desquamated pneumocytes.' Since then, these cells have been shown primarily to be pigmented alveolar macrophages. Other features include thickened alveolar septa with an infiltrate of inflammatory cells and plump, cuboidal type II pneumocytes. Mild collagen deposition without architectural distortion or honeycombing may be present. Different forms of ILD represent pathologic classifications based on histologic patterns rather than clinical diagnoses and may occur in a variety of clinical contexts (Visscher and Myers, 2006).&#13; Although DIP occurs most often as a sporadic disorder in adults during the third to fifth decade of life and is highly associated with smoking (Carrington et al., 1978), reports of a familial form with onset in infancy and early death suggest a genetic basis (Sharief et al., 1994).&#13; Cases of DIP reported in infants are often more severe and refractory to treatment than those reported in adults (Nogee et al., 2001).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/65962">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_82682"><div><strong>Lymphoid interstitial pneumonia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>82682</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0264511</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Lymphocytic interstitial pneumonitis is a benign lymphoproliferative disorder of the lung that is characterized by the presence of a dense, predominantly lymphocytic interstitial infiltrate (lymphocytes, plasma cells, other elements of the lymphoreticular system) that expands the alveolar septa.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/82682">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_220887"><div><strong>Hereditary mucoepithelial dysplasia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>220887</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1274795</a></dd><dt><span class="dotprefix"></span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
<div class="spaceAbove">Hereditary mucoepithelial dysplasia (HMD) is a rare autosomal dominant genodermatosis characterized by onset in infancy of a panepithelial defect involving the oral, nasal, conjunctival, vaginal, cervical, perineal, urethral, and bladder mucosa. Patients develop cataracts, blindness, nonscarring alopecia, perineal psoriasiform lesions, and follicular keratoses (Witkop et al., 1982). Although 1 family was reported to have progressive severe interstitial lung disease (Witkop et al., 1979), this feature has not been reported in other families and is not considered a criterion for diagnosis. However, the clinical triad of nonscarring alopecia, well-demarcated fiery red mucosa, and psoriasiform perineal involvement has been consistently observed (review by Boralevi et al., 2005).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/220887">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_349095"><div><strong>Chondroitin-6-sulfaturia, defective cellular immunity, nephrotic syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>349095</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1859104</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove nowrap">See: <a href="/medgen/349095">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_923943"><div><strong>Frontometaphyseal dysplasia 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>923943</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4281559</a></dd><dt><span class="dotprefix"></span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
<div class="spaceAbove">The X-linked otopalatodigital (X-OPD) spectrum disorders, characterized primarily by skeletal dysplasia, include the following: Otopalatodigital syndrome type 1 (OPD1). Otopalatodigital syndrome type 2 (OPD2). Frontometaphyseal dysplasia type 1 (FMD1). Melnick-Needles syndrome (MNS). Terminal osseous dysplasia with pigmentary skin defects (TODPD). In OPD1, most manifestations are present at birth; females can present with severity similar to affected males, although some have only mild manifestations. In OPD2, females are less severely affected than related affected males. Most males with OPD2 die during the first year of life, usually from thoracic hypoplasia resulting in pulmonary insufficiency. Males who live beyond the first year of life are usually developmentally delayed and require respiratory support and assistance with feeding. In FMD1, females are less severely affected than related affected males. Males do not experience a progressive skeletal dysplasia but may have joint contractures and hand and foot malformations. Progressive scoliosis is observed in both affected males and females. In MNS, wide phenotypic variability is observed; some individuals are diagnosed in adulthood, while others require respiratory support and have reduced longevity. MNS in males results in perinatal lethality in all recorded cases. TODPD, seen only in females, is characterized by a skeletal dysplasia that is most prominent in the digits, pigmentary defects of the skin, and recurrent digital fibromata.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/923943">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_349095" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Chondroitin-6-sulfaturia, defective cellular immunity, nephrotic syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_41393" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cystic fibrosis</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_65962" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Desquamative interstitial pneumonia</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_923943" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Frontometaphyseal dysplasia 1</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_220887" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hereditary mucoepithelial dysplasia</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_19310" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Isolated Pierre-Robin syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_82682" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Lymphoid interstitial pneumonia</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_65123" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">X-linked agammaglobulinemia</a></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/37464381">Management of severe acute respiratory distress syndrome: a primer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Grotberg JC,
Reynolds D,
Kraft BD</span><br />
<span class="medgenPMjournal">Crit Care</span>
2023 Jul 18;27(1):289.
doi: 10.1186/s13054-023-04572-w.
<span class="bold">PMID: </span><a href="/pubmed/37464381" target="_blank">37464381</a><a href="/pmc/articles/PMC10353255" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/650813">The treatment of cor pulmonale.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wynne JW</span><br />
<span class="medgenPMjournal">JAMA</span>
1978 May 26;239(21):2283-5.
<span class="bold">PMID: </span><a href="/pubmed/650813" target="_blank">650813</a></div>
<div class="nl"><a target="_blank" href="/pubmed/14348218">MANAGEMENT OF THE PATIENT WITH COR PULMONALE.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">HICKAM JB,
ROSS JC</span><br />
<span class="medgenPMjournal">Bull N Y Acad Med</span>
1965 Sep;41(9):994-1008.
<span class="bold">PMID: </span><a href="/pubmed/14348218" target="_blank">14348218</a><a href="/pmc/articles/PMC1750776" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22cor%20pulmonale%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (91)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/38765214">Intervention Versus Medical Management of Pulmonary Embolism.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Loh TM</span><br />
<span class="medgenPMjournal">Methodist Debakey Cardiovasc J</span>
2024;20(3):13-18.
Epub 2024 May 16
doi: 10.14797/mdcvj.1351.
<span class="bold">PMID: </span><a href="/pubmed/38765214" target="_blank">38765214</a><a href="/pmc/articles/PMC11100531" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37464381">Management of severe acute respiratory distress syndrome: a primer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Grotberg JC,
Reynolds D,
Kraft BD</span><br />
<span class="medgenPMjournal">Crit Care</span>
2023 Jul 18;27(1):289.
doi: 10.1186/s13054-023-04572-w.
<span class="bold">PMID: </span><a href="/pubmed/37464381" target="_blank">37464381</a><a href="/pmc/articles/PMC10353255" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34809919">Lung Disease-Related Pulmonary Hypertension.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ahmad K,
Khangoora V,
Nathan SD</span><br />
<span class="medgenPMjournal">Cardiol Clin</span>
2022 Feb;40(1):77-88.
doi: 10.1016/j.ccl.2021.08.005.
<span class="bold">PMID: </span><a href="/pubmed/34809919" target="_blank">34809919</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26593138">Pulmonary Sarcoidosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Valeyre D,
Bernaudin JF,
Jeny F,
Duchemann B,
Freynet O,
Planès C,
Kambouchner M,
Nunes H</span><br />
<span class="medgenPMjournal">Clin Chest Med</span>
2015 Dec;36(4):631-41.
doi: 10.1016/j.ccm.2015.08.006.
<span class="bold">PMID: </span><a href="/pubmed/26593138" target="_blank">26593138</a></div>
<div class="nl"><a target="_blank" href="/pubmed/8949588">Non-invasive ventilation.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Spence D</span><br />
<span class="medgenPMjournal">Postgrad Med J</span>
1996 Sep;72(851):532-4.
doi: 10.1136/pgmj.72.851.532.
<span class="bold">PMID: </span><a href="/pubmed/8949588" target="_blank">8949588</a><a href="/pmc/articles/PMC2398574" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cor%20pulmonale%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (502)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/34809919">Lung Disease-Related Pulmonary Hypertension.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ahmad K,
Khangoora V,
Nathan SD</span><br />
<span class="medgenPMjournal">Cardiol Clin</span>
2022 Feb;40(1):77-88.
doi: 10.1016/j.ccl.2021.08.005.
<span class="bold">PMID: </span><a href="/pubmed/34809919" target="_blank">34809919</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27613549">The right ventricle: interaction with the pulmonary circulation.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pinsky MR</span><br />
<span class="medgenPMjournal">Crit Care</span>
2016 Sep 10;20(1):266.
doi: 10.1186/s13054-016-1440-0.
<span class="bold">PMID: </span><a href="/pubmed/27613549" target="_blank">27613549</a><a href="/pmc/articles/PMC5018168" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26593138">Pulmonary Sarcoidosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Valeyre D,
Bernaudin JF,
Jeny F,
Duchemann B,
Freynet O,
Planès C,
Kambouchner M,
Nunes H</span><br />
<span class="medgenPMjournal">Clin Chest Med</span>
2015 Dec;36(4):631-41.
doi: 10.1016/j.ccm.2015.08.006.
<span class="bold">PMID: </span><a href="/pubmed/26593138" target="_blank">26593138</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19186411">Acute cor pulmonale.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Jardin F,
Vieillard-Baron A</span><br />
<span class="medgenPMjournal">Curr Opin Crit Care</span>
2009 Feb;15(1):67-70.
doi: 10.1097/mcc.0b013e3283220ddd.
<span class="bold">PMID: </span><a href="/pubmed/19186411" target="_blank">19186411</a></div>
<div class="nl"><a target="_blank" href="/pubmed/12527688">Chronic cor pulmonale.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Weitzenblum E</span><br />
<span class="medgenPMjournal">Heart</span>
2003 Feb;89(2):225-30.
doi: 10.1136/heart.89.2.225.
<span class="bold">PMID: </span><a href="/pubmed/12527688" target="_blank">12527688</a><a href="/pmc/articles/PMC1767533" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cor%20pulmonale%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (629)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/38765214">Intervention Versus Medical Management of Pulmonary Embolism.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Loh TM</span><br />
<span class="medgenPMjournal">Methodist Debakey Cardiovasc J</span>
2024;20(3):13-18.
Epub 2024 May 16
doi: 10.14797/mdcvj.1351.
<span class="bold">PMID: </span><a href="/pubmed/38765214" target="_blank">38765214</a><a href="/pmc/articles/PMC11100531" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32473695">Management of Right Ventricular Failure in Pulmonary Embolism.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zhao S,
Friedman O</span><br />
<span class="medgenPMjournal">Crit Care Clin</span>
2020 Jul;36(3):505-515.
Epub 2020 May 1
doi: 10.1016/j.ccc.2020.02.006.
<span class="bold">PMID: </span><a href="/pubmed/32473695" target="_blank">32473695</a></div>
<div class="nl"><a target="_blank" href="/pubmed/1298987">Hypoxemia in thalassemia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Fucharoen S,
Winichagoon P,
Siritanaratkul N,
Sonakul D,
Chantaraksri U,
Bunyaratvej A,
Piankijagum A,
Wasi P</span><br />
<span class="medgenPMjournal">Southeast Asian J Trop Med Public Health</span>
1992;23 Suppl 2:22-4.
<span class="bold">PMID: </span><a href="/pubmed/1298987" target="_blank">1298987</a></div>
<div class="nl"><a target="_blank" href="/pubmed/4152189">Acute respiratory insufficiency and cor pulmonale. Pathophysiology, clinical features, and management. II. Management.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Malovany RJ,
Koerner SK</span><br />
<span class="medgenPMjournal">Am Heart J</span>
1974 Aug;88(2):251-5.
doi: 10.1016/0002-8703(74)90017-9.
<span class="bold">PMID: </span><a href="/pubmed/4152189" target="_blank">4152189</a></div>
<div class="nl"><a target="_blank" href="/pubmed/4151572">Cor pulmonale.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sochocky S</span><br />
<span class="medgenPMjournal">S D J Med</span>
1974 May;27(5):5-10.
<span class="bold">PMID: </span><a href="/pubmed/4151572" target="_blank">4151572</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cor%20pulmonale%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (364)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/38765214">Intervention Versus Medical Management of Pulmonary Embolism.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Loh TM</span><br />
<span class="medgenPMjournal">Methodist Debakey Cardiovasc J</span>
2024;20(3):13-18.
Epub 2024 May 16
doi: 10.14797/mdcvj.1351.
<span class="bold">PMID: </span><a href="/pubmed/38765214" target="_blank">38765214</a><a href="/pmc/articles/PMC11100531" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19643833">Cor pulmonale.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Weitzenblum E,
Chaouat A</span><br />
<span class="medgenPMjournal">Chron Respir Dis</span>
2009;6(3):177-85.
doi: 10.1177/1479972309104664.
<span class="bold">PMID: </span><a href="/pubmed/19643833" target="_blank">19643833</a></div>
<div class="nl"><a target="_blank" href="/pubmed/15385647">Pheasant rearer's lung.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Partridge SJ,
Pepperell JC,
Forrester-Wood C,
Ibrahim NB,
Raynal A,
Swinburn CR</span><br />
<span class="medgenPMjournal">Occup Med (Lond)</span>
2004 Oct;54(7):500-3.
Epub 2004 Sep 22
doi: 10.1093/occmed/kqh092.
<span class="bold">PMID: </span><a href="/pubmed/15385647" target="_blank">15385647</a></div>
<div class="nl"><a target="_blank" href="/pubmed/12527688">Chronic cor pulmonale.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Weitzenblum E</span><br />
<span class="medgenPMjournal">Heart</span>
2003 Feb;89(2):225-30.
doi: 10.1136/heart.89.2.225.
<span class="bold">PMID: </span><a href="/pubmed/12527688" target="_blank">12527688</a><a href="/pmc/articles/PMC1767533" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/1298987">Hypoxemia in thalassemia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Fucharoen S,
Winichagoon P,
Siritanaratkul N,
Sonakul D,
Chantaraksri U,
Bunyaratvej A,
Piankijagum A,
Wasi P</span><br />
<span class="medgenPMjournal">Southeast Asian J Trop Med Public Health</span>
1992;23 Suppl 2:22-4.
<span class="bold">PMID: </span><a href="/pubmed/1298987" target="_blank">1298987</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cor%20pulmonale%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (392)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/38765214">Intervention Versus Medical Management of Pulmonary Embolism.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Loh TM</span><br />
<span class="medgenPMjournal">Methodist Debakey Cardiovasc J</span>
2024;20(3):13-18.
Epub 2024 May 16
doi: 10.14797/mdcvj.1351.
<span class="bold">PMID: </span><a href="/pubmed/38765214" target="_blank">38765214</a><a href="/pmc/articles/PMC11100531" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28285268">Cardiac manifestations of parasitic diseases.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Nunes MC,
Guimarães Júnior MH,
Diamantino AC,
Gelape CL,
Ferrari TC</span><br />
<span class="medgenPMjournal">Heart</span>
2017 May;103(9):651-658.
Epub 2017 Mar 11
doi: 10.1136/heartjnl-2016-309870.
<span class="bold">PMID: </span><a href="/pubmed/28285268" target="_blank">28285268</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22672932">Right ventricular failure in acute lung injury and acute respiratory distress syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Repessé X,
Charron C,
Vieillard-Baron A</span><br />
<span class="medgenPMjournal">Minerva Anestesiol</span>
2012 Aug;78(8):941-8.
Epub 2012 Jun 7
<span class="bold">PMID: </span><a href="/pubmed/22672932" target="_blank">22672932</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19186411">Acute cor pulmonale.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Jardin F,
Vieillard-Baron A</span><br />
<span class="medgenPMjournal">Curr Opin Crit Care</span>
2009 Feb;15(1):67-70.
doi: 10.1097/mcc.0b013e3283220ddd.
<span class="bold">PMID: </span><a href="/pubmed/19186411" target="_blank">19186411</a></div>
<div class="nl"><a target="_blank" href="/pubmed/17762231">Heart-lung interactions.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pinsky MR</span><br />
<span class="medgenPMjournal">Curr Opin Crit Care</span>
2007 Oct;13(5):528-31.
doi: 10.1097/MCC.0b013e3282efad97.
<span class="bold">PMID: </span><a href="/pubmed/17762231" target="_blank">17762231</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cor%20pulmonale%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (299)</a></div></div>
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<div class="nl"><a target="_blank" href="/pubmed/35043474">Approach to echocardiography in ARDS patients in the prone position: A systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ajam M,
Drake M,
Ran R,
Mukundan S,
Masri A,
Rahmouni H</span><br />
<span class="medgenPMjournal">Echocardiography</span>
2022 Feb;39(2):330-338.
Epub 2022 Jan 18
doi: 10.1111/echo.15294.
<span class="bold">PMID: </span><a href="/pubmed/35043474" target="_blank">35043474</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34118786">Mortality of right ventricular dysfunction in patients with acute respiratory distress syndrome subjected to lung protective ventilation: A systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Dong D,
Zong Y,
Li Z,
Wang Y,
Jing C</span><br />
<span class="medgenPMjournal">Heart Lung</span>
2021 Sep-Oct;50(5):730-735.
Epub 2021 Jun 9
doi: 10.1016/j.hrtlng.2021.04.011.
<span class="bold">PMID: </span><a href="/pubmed/34118786" target="_blank">34118786</a><a href="/pmc/articles/PMC9754927" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27543702">Digoxin therapy for cor pulmonale: A systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Alajaji W,
Baydoun A,
Al-Kindi SG,
Henry L,
Hanna MA,
Oliveira GH</span><br />
<span class="medgenPMjournal">Int J Cardiol</span>
2016 Nov 15;223:320-324.
Epub 2016 Aug 4
doi: 10.1016/j.ijcard.2016.08.018.
<span class="bold">PMID: </span><a href="/pubmed/27543702" target="_blank">27543702</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26603978">Shenmai injection as an adjuvant treatment for chronic cor pulmonale heart failure: a systematic review and meta-analysis of randomized controlled trials.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Shi L,
Xie Y,
Liao X,
Chai Y,
Luo Y</span><br />
<span class="medgenPMjournal">BMC Complement Altern Med</span>
2015 Nov 24;15:418.
doi: 10.1186/s12906-015-0939-2.
<span class="bold">PMID: </span><a href="/pubmed/26603978" target="_blank">26603978</a><a href="/pmc/articles/PMC4659214" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25395310">Salvia miltiorrhiza injection on pulmonary heart disease: a systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Liu Y,
Huang Y,
Zhao C,
Qin X,
Zhu Q,
Chen S,
Qu J</span><br />
<span class="medgenPMjournal">Am J Chin Med</span>
2014;42(6):1315-31.
doi: 10.1142/S0192415X14500827.
<span class="bold">PMID: </span><a href="/pubmed/25395310" target="_blank">25395310</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cor%20pulmonale%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (10)</a></div></div>
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