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<meta name="keywords" content="C5779643, alpha-tocopherol deficiency, decreased circulating vitamin e concentration, finding, low levels of vitamin e, vitamin e deficiency, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A reduced concentration of vitamin E in the blood circulation. Vitamin E is a lipophilic vitamin that is also known as alpha-tocopherol." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=1853278
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ConceptID=C5779643
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Decreased circulating vitamin E concentration</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1853278</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5779643</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Alpha-tocopherol deficiency; Low levels of vitamin E; Vitamin E deficiency</td></tr>
|
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<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0100513">HP:0100513</a></td></tr>
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</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">A reduced concentration of vitamin E in the blood circulation. Vitamin E is a lipophilic vitamin that is also known as alpha-tocopherol. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Decreased circulating vitamin E concentration</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/867398" ref="tree=MeSH" title="MedGen record for Abnormality of metabolism/homeostasis">Abnormality of metabolism/homeostasis</a></span><ul><li><span class="TLline"><a href="/medgen/1703500" ref="tree=MeSH" title="MedGen record for Abnormal metabolism">Abnormal metabolism</a></span><ul><li><span class="TLline"><a href="/medgen/867647" ref="tree=MeSH" title="MedGen record for Abnormality of vitamin metabolism">Abnormality of vitamin metabolism</a></span><ul><li><span class="TLline"><a href="/medgen/1841518" ref="tree=MeSH" title="MedGen record for Abnormal circulating vitamin E concentration">Abnormal circulating vitamin E concentration</a></span><ul><li><span class="matched_ds">Decreased circulating vitamin E concentration</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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||
<div class="divPopper rprt" id="rdis_341248"><div><strong>Familial isolated deficiency of vitamin E</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>341248</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C1848533</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Untreated ataxia with vitamin E deficiency (AVED) generally manifests between ages five and 15 years. The first manifestations include progressive ataxia, clumsiness of the hands, loss of proprioception, and areflexia. Other features often observed are dysdiadochokinesia, dysarthria, positive Romberg sign, head titubation, decreased visual acuity, and positive Babinski sign. Although age of onset and disease course are more uniform within a given family, disease manifestations and their severity can vary even among sibs. When lifelong high-dose vitamin E supplementation is initiated in presymptomatic individuals, manifestations of AVED do not develop.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/341248">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_388039"><div><strong>Congenital bile acid synthesis defect 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>388039</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1858328</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Congenital bile acid synthesis defect type 4 (BAS defect type 4) is an anomaly of bile acid synthesis (see this term) characterized by mild cholestatic liver disease, fat malabsorption and/or neurological disease.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/388039">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_934711"><div><strong>Bone marrow failure syndrome 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>934711</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4310744</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Bone marrow failure syndrome-3 is an autosomal recessive disorder characterized by onset of pancytopenia in early childhood. Patients may have additional variable nonspecific somatic abnormalities, including poor growth, microcephaly, and skin anomalies (summary by Tummala et al., 2016). BMFS3 has a distinct phenotype and may include features that overlap with Shwachman-Diamond syndrome (SDS1; 260400), such as pancreatic insufficiency and short stature, and with dyskeratosis congenita (see, e.g., DKCA1, 127550), such as dental and hair abnormalities and shortened telomeres. In addition, some patients may have joint and skeletal abnormalities, impaired development, and retinal dysplasia (summary by D'Amours et al., 2018). For a discussion of genetic heterogeneity of BMFS, see BMFS1 (614675).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/934711">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1639219"><div><strong>Familial hypobetalipoproteinemia 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1639219</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4551990</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Individuals with biallelic APOB-related familial hypobetalipoproteinemia (APOB-FHBL) may present from infancy through to adulthood with a range of clinical symptoms including deficiency of fat-soluble vitamins and gastrointestinal and neurologic dysfunction. Affected individuals typically have plasma total cholesterol, LDL cholesterol, and apo B levels below the fifth centile for age and sex. Acanthocytosis, elevated liver enzymes, and hyperbilirubinemia may also be found. The most common clinical findings are hepatomegaly, steatorrhea, and failure to thrive / growth deficiency. In the absence of treatment, affected individuals can develop atypical pigmentation of the retina; progressive loss of deep tendon reflexes, vibratory sense, and proprioception; muscle pain or weakness; dysarthria; ataxia; tremors; and steatohepatitis, fibrosis, and rarely, cirrhosis of the liver. Individuals with a heterozygous, typically truncating pathogenic variant in APOB are usually asymptomatic with mild liver dysfunction and hepatic steatosis. However, about 5%-10% of individuals with heterozygous APOB-FHBL develop relatively more severe nonalcoholic steatohepatitis requiring medical attention and occasionally progressing to cirrhosis, albeit very rarely.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1639219">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1794172"><div><strong>Bile acid malabsorption, primary, 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1794172</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5561962</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Primary bile acid malabsorption-2 (PBAM2) is an autosomal recessive disorder characterized by chronic diarrhea, severe fat-soluble vitamin deficiency, and features of cholestatic liver disease (Sultan et al., 2018). For discussion of genetic heterogeneity of primary bile acid malabsorption, see PBAM1 (613291).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1794172">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1823968"><div><strong>Liver disease, severe congenital</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1823968</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5774195</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Severe congenital liver disease (SCOLIV) is an autosomal recessive disorder characterized by the onset of progressive hepatic dysfunction usually in the first years of life. Affected individuals show feeding difficulties with failure to thrive and features such as jaundice, hepatomegaly, and abdominal distension. Laboratory workup is consistent with hepatic insufficiency and may also show coagulation defects, anemia, or metabolic disturbances. Cirrhosis and hypernodularity are commonly observed on liver biopsy. Many patients die of liver failure in early childhood (Moreno Traspas et al., 2022).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1823968">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1794172" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bile acid malabsorption, primary, 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_934711" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bone marrow failure syndrome 3</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_388039" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Congenital bile acid synthesis defect 4</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1639219" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial hypobetalipoproteinemia 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_341248" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial isolated deficiency of vitamin E</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1823968" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Liver disease, severe congenital</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/26177628">Novel nanosystem to enhance the antitumor activity of lapatinib in breast cancer treatment: Therapeutic efficacy evaluation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Huo ZJ,
|
||
Wang SJ,
|
||
Wang ZQ,
|
||
Zuo WS,
|
||
Liu P,
|
||
Pang B,
|
||
Liu K</span><br />
|
||
<span class="medgenPMjournal">Cancer Sci</span>
|
||
2015 Oct;106(10):1429-37.
|
||
Epub 2015 Aug 10
|
||
doi: 10.1111/cas.12737.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26177628" target="_blank">26177628</a><a href="/pmc/articles/PMC4637996" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/14981966">Retinol and tocopherol content in primary and metastatic digestive neoplasms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rocchi E,
|
||
Casalgrandi G,
|
||
Ronzoni A,
|
||
Rosa MC,
|
||
Marri L,
|
||
Gozzi C</span><br />
|
||
<span class="medgenPMjournal">Anticancer Res</span>
|
||
2003 Nov-Dec;23(6D):5049-54.
|
||
<span class="bold">PMID: </span><a href="/pubmed/14981966" target="_blank">14981966</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10869897">Changes in micronutrient concentrations following anti-inflammatory treatment in patients with gastrointestinal cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">McMillan DC,
|
||
Sattar N,
|
||
Talwar D,
|
||
O'Reilly DS,
|
||
McArdle CS</span><br />
|
||
<span class="medgenPMjournal">Nutrition</span>
|
||
2000 Jun;16(6):425-8.
|
||
doi: 10.1016/s0899-9007(00)00270-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10869897" target="_blank">10869897</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(decreased%20circulating%20vitamin%20e%20concentration)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (3)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35538486">Association between circulating vitamin E and ten common cancers: evidence from large-scale Mendelian randomization analysis and a longitudinal cohort study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Xin J,
|
||
Jiang X,
|
||
Ben S,
|
||
Yuan Q,
|
||
Su L,
|
||
Zhang Z,
|
||
Christiani DC,
|
||
Du M,
|
||
Wang M</span><br />
|
||
<span class="medgenPMjournal">BMC Med</span>
|
||
2022 May 11;20(1):168.
|
||
doi: 10.1186/s12916-022-02366-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35538486" target="_blank">35538486</a><a href="/pmc/articles/PMC9092790" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33167078">Vitamin A and D Absorption in Adults with Metabolic Syndrome versus Healthy Controls: A Pilot Study Utilizing Targeted and Untargeted LC-MS Lipidomics.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chatelaine H,
|
||
Dey P,
|
||
Mo X,
|
||
Mah E,
|
||
Bruno RS,
|
||
Kopec RE</span><br />
|
||
<span class="medgenPMjournal">Mol Nutr Food Res</span>
|
||
2021 Jan;65(2):e2000413.
|
||
Epub 2020 Dec 7
|
||
doi: 10.1002/mnfr.202000413.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33167078" target="_blank">33167078</a><a href="/pmc/articles/PMC7902427" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22402059">The effect of lipoic acid and vitamin E therapies in individuals with the metabolic syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Manning PJ,
|
||
Sutherland WH,
|
||
Williams SM,
|
||
Walker RJ,
|
||
Berry EA,
|
||
De Jong SA,
|
||
Ryalls AR</span><br />
|
||
<span class="medgenPMjournal">Nutr Metab Cardiovasc Dis</span>
|
||
2013 Jun;23(6):543-9.
|
||
Epub 2012 Mar 7
|
||
doi: 10.1016/j.numecd.2011.11.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22402059" target="_blank">22402059</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16076700">Diet, lifestyle and risk of prostate cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wolk A</span><br />
|
||
<span class="medgenPMjournal">Acta Oncol</span>
|
||
2005;44(3):277-81.
|
||
doi: 10.1080/02841860510029572.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16076700" target="_blank">16076700</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7617117">Evidence for oxidative stress during in vitro dialysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Westhuyzen J,
|
||
Adams CE,
|
||
Fleming SJ</span><br />
|
||
<span class="medgenPMjournal">Nephron</span>
|
||
1995;70(1):49-54.
|
||
doi: 10.1159/000188543.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7617117" target="_blank">7617117</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20vitamin%20E%20concentration%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (74)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/27139906">Vitamin E homologues α- and γ-tocopherol are not associated with bone turnover markers or bone mineral density in peri-menopausal and post-menopausal women.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yang TC,
|
||
Duthie GG,
|
||
Aucott LS,
|
||
Macdonald HM</span><br />
|
||
<span class="medgenPMjournal">Osteoporos Int</span>
|
||
2016 Jul;27(7):2281-2290.
|
||
Epub 2016 May 2
|
||
doi: 10.1007/s00198-015-3470-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27139906" target="_blank">27139906</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28531467">Cardiovascular risk and benefits from antioxidant dietary intervention with red wine in asymptomatic hypercholesterolemics.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Apostolidou C,
|
||
Adamopoulos K,
|
||
Lymperaki E,
|
||
Iliadis S,
|
||
Papapreponis P,
|
||
Kourtidou-Papadeli C</span><br />
|
||
<span class="medgenPMjournal">Clin Nutr ESPEN</span>
|
||
2015 Dec;10(6):e224-e233.
|
||
Epub 2015 Nov 14
|
||
doi: 10.1016/j.clnesp.2015.08.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28531467" target="_blank">28531467</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17696726">Impact of C-reactive protein on disease risk and its relation to dietary factors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nanri A,
|
||
Moore MA,
|
||
Kono S</span><br />
|
||
<span class="medgenPMjournal">Asian Pac J Cancer Prev</span>
|
||
2007 Apr-Jun;8(2):167-77.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17696726" target="_blank">17696726</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17299112">Vitamin E supplementation and plasma 8-isoprostane and adiponectin in overweight subjects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sutherland WH,
|
||
Manning PJ,
|
||
Walker RJ,
|
||
de Jong SA,
|
||
Ryalls AR,
|
||
Berry EA</span><br />
|
||
<span class="medgenPMjournal">Obesity (Silver Spring)</span>
|
||
2007 Feb;15(2):386-91.
|
||
doi: 10.1038/oby.2007.546.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17299112" target="_blank">17299112</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15333479">Effect of high-dose vitamin E on insulin resistance and associated parameters in overweight subjects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Manning PJ,
|
||
Sutherland WH,
|
||
Walker RJ,
|
||
Williams SM,
|
||
De Jong SA,
|
||
Ryalls AR,
|
||
Berry EA</span><br />
|
||
<span class="medgenPMjournal">Diabetes Care</span>
|
||
2004 Sep;27(9):2166-71.
|
||
doi: 10.2337/diacare.27.9.2166.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15333479" target="_blank">15333479</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20vitamin%20E%20concentration%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (16)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35538486">Association between circulating vitamin E and ten common cancers: evidence from large-scale Mendelian randomization analysis and a longitudinal cohort study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Xin J,
|
||
Jiang X,
|
||
Ben S,
|
||
Yuan Q,
|
||
Su L,
|
||
Zhang Z,
|
||
Christiani DC,
|
||
Du M,
|
||
Wang M</span><br />
|
||
<span class="medgenPMjournal">BMC Med</span>
|
||
2022 May 11;20(1):168.
|
||
doi: 10.1186/s12916-022-02366-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35538486" target="_blank">35538486</a><a href="/pmc/articles/PMC9092790" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33167078">Vitamin A and D Absorption in Adults with Metabolic Syndrome versus Healthy Controls: A Pilot Study Utilizing Targeted and Untargeted LC-MS Lipidomics.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chatelaine H,
|
||
Dey P,
|
||
Mo X,
|
||
Mah E,
|
||
Bruno RS,
|
||
Kopec RE</span><br />
|
||
<span class="medgenPMjournal">Mol Nutr Food Res</span>
|
||
2021 Jan;65(2):e2000413.
|
||
Epub 2020 Dec 7
|
||
doi: 10.1002/mnfr.202000413.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33167078" target="_blank">33167078</a><a href="/pmc/articles/PMC7902427" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22402059">The effect of lipoic acid and vitamin E therapies in individuals with the metabolic syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Manning PJ,
|
||
Sutherland WH,
|
||
Williams SM,
|
||
Walker RJ,
|
||
Berry EA,
|
||
De Jong SA,
|
||
Ryalls AR</span><br />
|
||
<span class="medgenPMjournal">Nutr Metab Cardiovasc Dis</span>
|
||
2013 Jun;23(6):543-9.
|
||
Epub 2012 Mar 7
|
||
doi: 10.1016/j.numecd.2011.11.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22402059" target="_blank">22402059</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22133051">Dietary factors and low-grade inflammation in relation to overweight and obesity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Calder PC,
|
||
Ahluwalia N,
|
||
Brouns F,
|
||
Buetler T,
|
||
Clement K,
|
||
Cunningham K,
|
||
Esposito K,
|
||
Jönsson LS,
|
||
Kolb H,
|
||
Lansink M,
|
||
Marcos A,
|
||
Margioris A,
|
||
Matusheski N,
|
||
Nordmann H,
|
||
O'Brien J,
|
||
Pugliese G,
|
||
Rizkalla S,
|
||
Schalkwijk C,
|
||
Tuomilehto J,
|
||
Wärnberg J,
|
||
Watzl B,
|
||
Winklhofer-Roob BM</span><br />
|
||
<span class="medgenPMjournal">Br J Nutr</span>
|
||
2011 Dec;106 Suppl 3:S5-78.
|
||
doi: 10.1017/S0007114511005460.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22133051" target="_blank">22133051</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16076700">Diet, lifestyle and risk of prostate cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wolk A</span><br />
|
||
<span class="medgenPMjournal">Acta Oncol</span>
|
||
2005;44(3):277-81.
|
||
doi: 10.1080/02841860510029572.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16076700" target="_blank">16076700</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20vitamin%20E%20concentration%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (67)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35538486">Association between circulating vitamin E and ten common cancers: evidence from large-scale Mendelian randomization analysis and a longitudinal cohort study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Xin J,
|
||
Jiang X,
|
||
Ben S,
|
||
Yuan Q,
|
||
Su L,
|
||
Zhang Z,
|
||
Christiani DC,
|
||
Du M,
|
||
Wang M</span><br />
|
||
<span class="medgenPMjournal">BMC Med</span>
|
||
2022 May 11;20(1):168.
|
||
doi: 10.1186/s12916-022-02366-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35538486" target="_blank">35538486</a><a href="/pmc/articles/PMC9092790" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27591823">Circulating interleukin-6 is not altered while γ-tocopherol is increased in subjects scheduled for knee surgery with low vitamin D.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Barker T,
|
||
Henriksen VT,
|
||
Rogers VE,
|
||
Momberger NG,
|
||
Rasmussen GL,
|
||
Trawick RH</span><br />
|
||
<span class="medgenPMjournal">Cytokine</span>
|
||
2016 Dec;88:108-114.
|
||
Epub 2016 Sep 1
|
||
doi: 10.1016/j.cyto.2016.08.025.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27591823" target="_blank">27591823</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17696726">Impact of C-reactive protein on disease risk and its relation to dietary factors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nanri A,
|
||
Moore MA,
|
||
Kono S</span><br />
|
||
<span class="medgenPMjournal">Asian Pac J Cancer Prev</span>
|
||
2007 Apr-Jun;8(2):167-77.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17696726" target="_blank">17696726</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16702618">Asymmetric dimethylarginine (ADMA) as a target for pharmacotherapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bełtowski J,
|
||
Kedra A</span><br />
|
||
<span class="medgenPMjournal">Pharmacol Rep</span>
|
||
2006 Mar-Apr;58(2):159-78.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16702618" target="_blank">16702618</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8625625">Plasma concentrations of cytokines, their soluble receptors, and antioxidant vitamins can predict the development of multiple organ failure in patients at risk.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Borrelli E,
|
||
Roux-Lombard P,
|
||
Grau GE,
|
||
Girardin E,
|
||
Ricou B,
|
||
Dayer J,
|
||
Suter PM</span><br />
|
||
<span class="medgenPMjournal">Crit Care Med</span>
|
||
1996 Mar;24(3):392-7.
|
||
doi: 10.1097/00003246-199603000-00006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8625625" target="_blank">8625625</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20vitamin%20E%20concentration%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (18)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35538486">Association between circulating vitamin E and ten common cancers: evidence from large-scale Mendelian randomization analysis and a longitudinal cohort study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Xin J,
|
||
Jiang X,
|
||
Ben S,
|
||
Yuan Q,
|
||
Su L,
|
||
Zhang Z,
|
||
Christiani DC,
|
||
Du M,
|
||
Wang M</span><br />
|
||
<span class="medgenPMjournal">BMC Med</span>
|
||
2022 May 11;20(1):168.
|
||
doi: 10.1186/s12916-022-02366-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35538486" target="_blank">35538486</a><a href="/pmc/articles/PMC9092790" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33167078">Vitamin A and D Absorption in Adults with Metabolic Syndrome versus Healthy Controls: A Pilot Study Utilizing Targeted and Untargeted LC-MS Lipidomics.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chatelaine H,
|
||
Dey P,
|
||
Mo X,
|
||
Mah E,
|
||
Bruno RS,
|
||
Kopec RE</span><br />
|
||
<span class="medgenPMjournal">Mol Nutr Food Res</span>
|
||
2021 Jan;65(2):e2000413.
|
||
Epub 2020 Dec 7
|
||
doi: 10.1002/mnfr.202000413.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33167078" target="_blank">33167078</a><a href="/pmc/articles/PMC7902427" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16702618">Asymmetric dimethylarginine (ADMA) as a target for pharmacotherapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bełtowski J,
|
||
Kedra A</span><br />
|
||
<span class="medgenPMjournal">Pharmacol Rep</span>
|
||
2006 Mar-Apr;58(2):159-78.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16702618" target="_blank">16702618</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16076700">Diet, lifestyle and risk of prostate cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wolk A</span><br />
|
||
<span class="medgenPMjournal">Acta Oncol</span>
|
||
2005;44(3):277-81.
|
||
doi: 10.1080/02841860510029572.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16076700" target="_blank">16076700</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11041217">Oxidative stress, vitamin E and progestin breakthrough bleeding.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Subakir SB,
|
||
Abdul Madjid O,
|
||
Sabariah S,
|
||
Affandi B</span><br />
|
||
<span class="medgenPMjournal">Hum Reprod</span>
|
||
2000 Aug;15 Suppl 3:18-23.
|
||
doi: 10.1093/humrep/15.suppl_3.18.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11041217" target="_blank">11041217</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20vitamin%20E%20concentration%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (43)</a></div></div>
|
||
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|
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|
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|
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|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(decreased%20circulating%20vitamin%20e%20concentration)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Decreased%20circulating%20vitamin%20E%20concentration%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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