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<!--
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UID=1830276
|
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ConceptID=C5779554
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Retinal arteriolar tortuosity</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1830276</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5779554</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Tortuous retinal arterioles</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0001136">HP:0001136</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">The presence of an increased number of twists and turns of the retinal arterioles. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Retinal arteriolar tortuosity</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/1370071" ref="tree=MeSH" title="MedGen record for Abnormality of the eye">Abnormality of the eye</a></span><ul><li><span class="TLline"><a href="/medgen/868526" ref="tree=MeSH" title="MedGen record for Abnormal eye morphology">Abnormal eye morphology</a></span><ul><li><span class="TLline"><a href="/medgen/870310" ref="tree=MeSH" title="MedGen record for Abnormality of the vasculature of the eye">Abnormality of the vasculature of the eye</a></span><ul><li><span class="TLline"><a href="/medgen/870311" ref="tree=MeSH" title="MedGen record for Abnormal retinal vascular morphology">Abnormal retinal vascular morphology</a></span><ul><li><span class="TLline"><a href="/medgen/349827" ref="tree=MeSH" title="MedGen record for Retinal vascular tortuosity">Retinal vascular tortuosity</a></span><ul><li><span class="matched_ds">Retinal arteriolar tortuosity</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
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||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_59799"><div><strong>Williams syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>59799</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0175702</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Williams syndrome (WS) is characterized by developmental delay, intellectual disability (usually mild), a specific cognitive profile, unique personality characteristics, cardiovascular disease (supravalvar aortic stenosis, peripheral pulmonary stenosis, hypertension), connective tissue abnormalities, growth deficiency, endocrine abnormalities (early puberty, hypercalcemia, hypercalciuria, hypothyroidism), and distinctive facies. Hypotonia and hyperextensible joints can result in delayed attainment of motor milestones. Feeding difficulties often lead to poor weight gain in infancy.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/59799">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_98034"><div><strong>GAPO syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>98034</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0406723</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">GAPO syndrome is the acronymic designation for a complex of growth retardation, alopecia, pseudoanodontia (failure of tooth eruption), and progressive optic atrophy (Tipton and Gorlin, 1984). Ilker et al. (1999) and Bayram et al. (2014) noted that optic atrophy is not a consistent feature of the disorder.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/98034">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_140840"><div><strong>Retinal arterial tortuosity</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>140840</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0423401</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial retinal arterial tortuosity is characterized by marked tortuosity of second- and third-order retinal arteries with normal first-order arteries and venous system. Two-thirds of patients experience variable degrees of symptomatic transient vision loss due to retinal hemorrhage following minor stress or trauma (summary by Nischler et al., 2011).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/140840">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_382033"><div><strong>Autosomal dominant familial hematuria-retinal arteriolar tortuosity-contractures syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>382033</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2673195</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The spectrum of COL4A1-related disorders includes: small-vessel brain disease of varying severity including porencephaly, variably associated with eye defects (retinal arterial tortuosity, Axenfeld-Rieger anomaly, cataract) and systemic findings (kidney involvement, muscle cramps, cerebral aneurysms, Raynaud phenomenon, cardiac arrhythmia, and hemolytic anemia). On imaging studies, small-vessel brain disease is manifest as diffuse periventricular leukoencephalopathy, lacunar infarcts, microhemorrhage, dilated perivascular spaces, and deep intracerebral hemorrhages. Clinically, small-vessel brain disease manifests as infantile hemiparesis, seizures, single or recurrent hemorrhagic stroke, ischemic stroke, and isolated migraine with aura. Porencephaly (fluid-filled cavities in the brain detected by CT or MRI) is typically manifest as infantile hemiparesis, seizures, and intellectual disability; however, on occasion it can be an incidental finding. HANAC (hereditary angiopathy with nephropathy, aneurysms, and muscle cramps) syndrome usually associates asymptomatic small-vessel brain disease, cerebral large vessel involvement (i.e., aneurysms), and systemic findings involving the kidney, muscle, and small vessels of the eye. Two additional phenotypes include isolated retinal artery tortuosity and nonsyndromic autosomal dominant congenital cataract.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/382033">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1647320"><div><strong>Brain small vessel disease 1 with or without ocular anomalies</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1647320</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4551998</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The spectrum of COL4A1-related disorders includes: small-vessel brain disease of varying severity including porencephaly, variably associated with eye defects (retinal arterial tortuosity, Axenfeld-Rieger anomaly, cataract) and systemic findings (kidney involvement, muscle cramps, cerebral aneurysms, Raynaud phenomenon, cardiac arrhythmia, and hemolytic anemia). On imaging studies, small-vessel brain disease is manifest as diffuse periventricular leukoencephalopathy, lacunar infarcts, microhemorrhage, dilated perivascular spaces, and deep intracerebral hemorrhages. Clinically, small-vessel brain disease manifests as infantile hemiparesis, seizures, single or recurrent hemorrhagic stroke, ischemic stroke, and isolated migraine with aura. Porencephaly (fluid-filled cavities in the brain detected by CT or MRI) is typically manifest as infantile hemiparesis, seizures, and intellectual disability; however, on occasion it can be an incidental finding. HANAC (hereditary angiopathy with nephropathy, aneurysms, and muscle cramps) syndrome usually associates asymptomatic small-vessel brain disease, cerebral large vessel involvement (i.e., aneurysms), and systemic findings involving the kidney, muscle, and small vessels of the eye. Two additional phenotypes include isolated retinal artery tortuosity and nonsyndromic autosomal dominant congenital cataract.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1647320">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_382033" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal dominant familial hematuria-retinal arteriolar tortuosity-contractures syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1647320" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Brain small vessel disease 1 with or without ocular anomalies</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_98034" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">GAPO syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_140840" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Retinal arterial tortuosity</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_59799" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Williams syndrome</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38430271">Retinal imaging for the assessment of stroke risk: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Girach Z,
|
||
Sarian A,
|
||
Maldonado-García C,
|
||
Ravikumar N,
|
||
Sergouniotis PI,
|
||
Rothwell PM,
|
||
Frangi AF,
|
||
Julian TH</span><br />
|
||
<span class="medgenPMjournal">J Neurol</span>
|
||
2024 May;271(5):2285-2297.
|
||
Epub 2024 Mar 2
|
||
doi: 10.1007/s00415-023-12171-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38430271" target="_blank">38430271</a><a href="/pmc/articles/PMC11055692" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21907122">Computer-assisted image analysis of temporal retinal vessel width and tortuosity in retinopathy of prematurity for the assessment of disease severity and treatment outcome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cheung CS,
|
||
Butty Z,
|
||
Tehrani NN,
|
||
Lam WC</span><br />
|
||
<span class="medgenPMjournal">J AAPOS</span>
|
||
2011 Aug;15(4):374-80.
|
||
doi: 10.1016/j.jaapos.2011.05.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21907122" target="_blank">21907122</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(retinal%20arteriolar%20tortuosity)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (2)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39405554">ASSESSMENT OF RETINAL ARTERIOLAR TORTUOSITY IN PATIENTS WITH COL4A1 OR COL4A2 MUTATIONS.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Krivosic V,
|
||
Goupillou P,
|
||
Buffon-Porcher F,
|
||
Morel H,
|
||
Guey S,
|
||
Tadayoni R,
|
||
Lasserve ET,
|
||
Chabriat H,
|
||
Gaudric A</span><br />
|
||
<span class="medgenPMjournal">Retina</span>
|
||
2025 Feb 1;45(2):296-302.
|
||
doi: 10.1097/IAE.0000000000004290.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39405554" target="_blank">39405554</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37589562">Ocular features in Williams-Beuren syndrome: a review of the literature.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nassisi M,
|
||
Mainetti C,
|
||
Aretti A,
|
||
Sperti A,
|
||
Nicotra V,
|
||
Rinaldi B,
|
||
Natacci F,
|
||
Bedeschi MF,
|
||
Viola F</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Ophthalmol</span>
|
||
2023 Nov 1;34(6):514-521.
|
||
Epub 2023 Aug 17
|
||
doi: 10.1097/ICU.0000000000000990.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37589562" target="_blank">37589562</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34160658">Retinal arteriolar tortuosity and fractal dimension are associated with long-term cardiovascular outcomes in people with type 2 diabetes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sandoval-Garcia E,
|
||
McLachlan S,
|
||
Price AH,
|
||
MacGillivray TJ,
|
||
Strachan MWJ,
|
||
Wilson JF,
|
||
Price JF</span><br />
|
||
<span class="medgenPMjournal">Diabetologia</span>
|
||
2021 Oct;64(10):2215-2227.
|
||
Epub 2021 Jun 23
|
||
doi: 10.1007/s00125-021-05499-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34160658" target="_blank">34160658</a><a href="/pmc/articles/PMC8423701" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31597446">Novel Genetic Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk of Coronary Artery Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Veluchamy A,
|
||
Ballerini L,
|
||
Vitart V,
|
||
Schraut KE,
|
||
Kirin M,
|
||
Campbell H,
|
||
Joshi PK,
|
||
Relan D,
|
||
Harris S,
|
||
Brown E,
|
||
Vaidya SS,
|
||
Dhillon B,
|
||
Zhou K,
|
||
Pearson ER,
|
||
Hayward C,
|
||
Polasek O,
|
||
Deary IJ,
|
||
MacGillivray T,
|
||
Wilson JF,
|
||
Trucco E,
|
||
Palmer CNA,
|
||
Doney ASF</span><br />
|
||
<span class="medgenPMjournal">Arterioscler Thromb Vasc Biol</span>
|
||
2019 Dec;39(12):2542-2552.
|
||
Epub 2019 Oct 10
|
||
doi: 10.1161/ATVBAHA.119.312552.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31597446" target="_blank">31597446</a><a href="/pmc/articles/PMC6882544" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31466896">Retinal vascular tortuosity in schizophrenia and bipolar disorder.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Appaji A,
|
||
Nagendra B,
|
||
Chako DM,
|
||
Padmanabha A,
|
||
Jacob A,
|
||
Hiremath CV,
|
||
Varambally S,
|
||
Kesavan M,
|
||
Venkatasubramanian G,
|
||
Rao SV,
|
||
Webers CAB,
|
||
Berendschot TTJM,
|
||
Rao NP</span><br />
|
||
<span class="medgenPMjournal">Schizophr Res</span>
|
||
2019 Oct;212:26-32.
|
||
Epub 2019 Aug 26
|
||
doi: 10.1016/j.schres.2019.08.020.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31466896" target="_blank">31466896</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Retinal%20arteriolar%20tortuosity%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (21)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34503761">Spontaneous Retinal Hemorrhages Associated with Familial Retinal Arteriolar Tortuosity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Finn AP,
|
||
Arif S,
|
||
Khurana RN</span><br />
|
||
<span class="medgenPMjournal">Ophthalmol Retina</span>
|
||
2021 Sep;5(9):917.
|
||
doi: 10.1016/j.oret.2021.06.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34503761" target="_blank">34503761</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33080177">Diffuse spontaneous intraretinal hemorrhages in familial retinal arteriolar tortuosity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pollmann AS,
|
||
Mishra AV,
|
||
Francisconi CLM</span><br />
|
||
<span class="medgenPMjournal">Can J Ophthalmol</span>
|
||
2021 Jun;56(3):211.
|
||
Epub 2020 Oct 17
|
||
doi: 10.1016/j.jcjo.2020.09.014.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33080177" target="_blank">33080177</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32955594">Unilateral Situs Inversus of the Optic Disc in a Patient With Retinal Arteriolar Tortuosity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hsu CC,
|
||
Feng KM,
|
||
Chang YH</span><br />
|
||
<span class="medgenPMjournal">Ophthalmic Surg Lasers Imaging Retina</span>
|
||
2020 Sep 1;51(9):533-535.
|
||
doi: 10.3928/23258160-20200831-09.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32955594" target="_blank">32955594</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26967753">Familial Retinal Arteriolar Tortuosity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Khan MA,
|
||
Pheasant TR,
|
||
Shields CL</span><br />
|
||
<span class="medgenPMjournal">JAMA Ophthalmol</span>
|
||
2016 Mar;134(3):e154133.
|
||
Epub 2016 Mar 10
|
||
doi: 10.1001/jamaophthalmol.2015.4133.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26967753" target="_blank">26967753</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23623391">Retinal arteriolar tortuosity and artery occlusion.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chavala SH,
|
||
Williamson JF</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2013 Nov 16;382(9905):1655.
|
||
Epub 2013 Apr 26
|
||
doi: 10.1016/S0140-6736(13)60143-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23623391" target="_blank">23623391</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Retinal%20arteriolar%20tortuosity%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (30)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39283358">The role of Perifoveal Arteriolar Tortuosity in Optical Coherence Tomography Angiography (OCTA) images as an early indicator of hypertensive retinopathy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Park J,
|
||
Vyas C,
|
||
İnam O,
|
||
Zhou HW,
|
||
Snow ZE,
|
||
Karani R,
|
||
Koenigstein D,
|
||
Tezel TH</span><br />
|
||
<span class="medgenPMjournal">Graefes Arch Clin Exp Ophthalmol</span>
|
||
2025 Jan;263(1):121-129.
|
||
Epub 2024 Sep 16
|
||
doi: 10.1007/s00417-024-06629-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39283358" target="_blank">39283358</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33436709">High-salt intake affects retinal vascular tortuosity in healthy males: an exploratory randomized cross-over trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wenstedt EFE,
|
||
Beugelink L,
|
||
Schrooten EM,
|
||
Rademaker E,
|
||
Rorije NMG,
|
||
Wouda RD,
|
||
Schlingemann RO,
|
||
Wong TY,
|
||
Vogt L</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2021 Jan 12;11(1):801.
|
||
doi: 10.1038/s41598-020-79753-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33436709" target="_blank">33436709</a><a href="/pmc/articles/PMC7803999" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32293357">Bilateral and multiple sub-internal limiting membrane hemorrhages in a familial retinal arteriolar tortuosity patient by Valsalva-like mechanism: an observational case report.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chen T,
|
||
Zheng H,
|
||
Wang Y,
|
||
Hu J,
|
||
Chen C</span><br />
|
||
<span class="medgenPMjournal">BMC Ophthalmol</span>
|
||
2020 Apr 15;20(1):151.
|
||
doi: 10.1186/s12886-020-01413-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32293357" target="_blank">32293357</a><a href="/pmc/articles/PMC7161018" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Retinal%20arteriolar%20tortuosity%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34160658">Retinal arteriolar tortuosity and fractal dimension are associated with long-term cardiovascular outcomes in people with type 2 diabetes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sandoval-Garcia E,
|
||
McLachlan S,
|
||
Price AH,
|
||
MacGillivray TJ,
|
||
Strachan MWJ,
|
||
Wilson JF,
|
||
Price JF</span><br />
|
||
<span class="medgenPMjournal">Diabetologia</span>
|
||
2021 Oct;64(10):2215-2227.
|
||
Epub 2021 Jun 23
|
||
doi: 10.1007/s00125-021-05499-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34160658" target="_blank">34160658</a><a href="/pmc/articles/PMC8423701" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31545560">Retinal vascular fractal dimension and cerebral blood flow, a pilot study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nadal J,
|
||
Deverdun J,
|
||
de Champfleur NM,
|
||
Carriere I,
|
||
Creuzot-Garcher C,
|
||
Delcourt C,
|
||
Chiquet C,
|
||
Kawasaki R,
|
||
Villain M,
|
||
Ritchie K,
|
||
Le Bars E,
|
||
Daien V</span><br />
|
||
<span class="medgenPMjournal">Acta Ophthalmol</span>
|
||
2020 Feb;98(1):e63-e71.
|
||
Epub 2019 Sep 23
|
||
doi: 10.1111/aos.14232.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31545560" target="_blank">31545560</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31466896">Retinal vascular tortuosity in schizophrenia and bipolar disorder.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Appaji A,
|
||
Nagendra B,
|
||
Chako DM,
|
||
Padmanabha A,
|
||
Jacob A,
|
||
Hiremath CV,
|
||
Varambally S,
|
||
Kesavan M,
|
||
Venkatasubramanian G,
|
||
Rao SV,
|
||
Webers CAB,
|
||
Berendschot TTJM,
|
||
Rao NP</span><br />
|
||
<span class="medgenPMjournal">Schizophr Res</span>
|
||
2019 Oct;212:26-32.
|
||
Epub 2019 Aug 26
|
||
doi: 10.1016/j.schres.2019.08.020.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31466896" target="_blank">31466896</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29927466">Optical Coherence Tomography Angiography of Familial Retinal Arteriolar Tortuosity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Giocanti-Auregan A,
|
||
Gaudric A,
|
||
Buffon F,
|
||
Mine M,
|
||
Delahaye-Mazza C,
|
||
Cohen SY,
|
||
Erginay A,
|
||
Chabriat H,
|
||
Lasserve ET,
|
||
Krivosic V</span><br />
|
||
<span class="medgenPMjournal">Ophthalmic Surg Lasers Imaging Retina</span>
|
||
2018 Jun 1;49(6):397-401.
|
||
doi: 10.3928/23258160-20180601-03.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29927466" target="_blank">29927466</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26086266">Retinal Vessel Tortuosity and Its Relation to Traditional and Novel Vascular Risk Markers in Persons with Diabetes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sasongko MB,
|
||
Wong TY,
|
||
Nguyen TT,
|
||
Cheung CY,
|
||
Shaw JE,
|
||
Kawasaki R,
|
||
Lamoureux EL,
|
||
Wang JJ</span><br />
|
||
<span class="medgenPMjournal">Curr Eye Res</span>
|
||
2016 Apr;41(4):551-7.
|
||
Epub 2015 Jun 18
|
||
doi: 10.3109/02713683.2015.1034371.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26086266" target="_blank">26086266</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Retinal%20arteriolar%20tortuosity%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (11)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35760456">Novel ophthalmic findings and deep phenotyping in Williams-Beuren syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Huryn LA,
|
||
Flaherty T,
|
||
Nolen R,
|
||
Prasov L,
|
||
Zein WM,
|
||
Cukras CA,
|
||
Osgood S,
|
||
Raja N,
|
||
Levin MD,
|
||
Vitale S,
|
||
Brooks BP,
|
||
Hufnagel RB,
|
||
Kozel BA</span><br />
|
||
<span class="medgenPMjournal">Br J Ophthalmol</span>
|
||
2023 Oct;107(10):1554-1559.
|
||
Epub 2022 Jun 27
|
||
doi: 10.1136/bjophthalmol-2022-321103.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35760456" target="_blank">35760456</a><a href="/pmc/articles/PMC10074447" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33446119">Association of reduced retinal arteriolar tortuosity with depression in older participants from the Northern Ireland Cohort for the Longitudinal Study of Ageing.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">O'Neill RA,
|
||
Maxwell AP,
|
||
Kee F,
|
||
Young I,
|
||
Hogg RE,
|
||
Cruise S,
|
||
McGuinness B,
|
||
McKay GJ</span><br />
|
||
<span class="medgenPMjournal">BMC Geriatr</span>
|
||
2021 Jan 15;21(1):62.
|
||
doi: 10.1186/s12877-021-02009-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33446119" target="_blank">33446119</a><a href="/pmc/articles/PMC7809811" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31466896">Retinal vascular tortuosity in schizophrenia and bipolar disorder.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Appaji A,
|
||
Nagendra B,
|
||
Chako DM,
|
||
Padmanabha A,
|
||
Jacob A,
|
||
Hiremath CV,
|
||
Varambally S,
|
||
Kesavan M,
|
||
Venkatasubramanian G,
|
||
Rao SV,
|
||
Webers CAB,
|
||
Berendschot TTJM,
|
||
Rao NP</span><br />
|
||
<span class="medgenPMjournal">Schizophr Res</span>
|
||
2019 Oct;212:26-32.
|
||
Epub 2019 Aug 26
|
||
doi: 10.1016/j.schres.2019.08.020.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31466896" target="_blank">31466896</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29927466">Optical Coherence Tomography Angiography of Familial Retinal Arteriolar Tortuosity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Giocanti-Auregan A,
|
||
Gaudric A,
|
||
Buffon F,
|
||
Mine M,
|
||
Delahaye-Mazza C,
|
||
Cohen SY,
|
||
Erginay A,
|
||
Chabriat H,
|
||
Lasserve ET,
|
||
Krivosic V</span><br />
|
||
<span class="medgenPMjournal">Ophthalmic Surg Lasers Imaging Retina</span>
|
||
2018 Jun 1;49(6):397-401.
|
||
doi: 10.3928/23258160-20180601-03.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29927466" target="_blank">29927466</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15882279">Autosomal-dominant familial hematuria with retinal arteriolar tortuosity and contractures: a novel syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Plaisier E,
|
||
Alamowitch S,
|
||
Gribouval O,
|
||
Mougenot B,
|
||
Gaudric A,
|
||
Antignac C,
|
||
Roullet E,
|
||
Ronco P</span><br />
|
||
<span class="medgenPMjournal">Kidney Int</span>
|
||
2005 Jun;67(6):2354-60.
|
||
doi: 10.1111/j.1523-1755.2005.00341.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15882279" target="_blank">15882279</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Retinal%20arteriolar%20tortuosity%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (13)</a></div></div>
|
||
</div>
|
||
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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