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<!--
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UID=1771435
|
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ConceptID=C5421603
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Increased urine succinate level</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1771435</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5421603</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0033092">HP:0033092</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">The concentration of succinate in the urine, normalized for urine concentration, is above the upper limit of normal. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Increased urine succinate level</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/869020" ref="tree=MeSH" title="MedGen record for Abnormality of the urinary system physiology">Abnormality of the urinary system physiology</a></span><ul><li><span class="TLline"><a href="/medgen/871178" ref="tree=MeSH" title="MedGen record for Abnormality of urine homeostasis">Abnormality of urine homeostasis</a></span><ul><li><span class="TLline"><a href="/medgen/1785188" ref="tree=MeSH" title="MedGen record for Abnormal urine metabolite level">Abnormal urine metabolite level</a></span><ul><li><span class="TLline"><a href="/medgen/1671015" ref="tree=MeSH" title="MedGen record for Abnormal urine carboxylic acid level">Abnormal urine carboxylic acid level</a></span><ul><li><span class="TLline"><a href="/medgen/868022" ref="tree=MeSH" title="MedGen record for Elevated urinary carboxylic acid">Elevated urinary carboxylic acid</a></span><ul><li><span class="TLline"><a href="/medgen/343550" ref="tree=MeSH" title="MedGen record for Dicarboxylic aciduria">Dicarboxylic aciduria</a></span><ul><li><span class="matched_ds">Increased urine succinate level</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_87458"><div><strong>Fumarase deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>87458</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0342770</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Fumarate hydratase (FH) deficiency results in severe neonatal and early infantile encephalopathy that is characterized by poor feeding, failure to thrive, hypotonia, lethargy, and seizures. Dysmorphic facial features include frontal bossing, depressed nasal bridge, and widely spaced eyes. Many affected individuals are microcephalic. A spectrum of brain abnormalities are seen on magnetic resonance imaging, including cerebral atrophy, enlarged ventricles and generous extra-axial cerebral spinal fluid (CSF) spaces, delayed myelination for age, thinning of the corpus callosum, and an abnormally small brain stem. Brain malformations including bilateral polymicrogyria and absence of the corpus callosum can also be observed. Development is severely affected: most affected individuals are nonverbal and nonambulatory, and many die during early childhood. Less severely affected individuals with moderate cognitive impairment and long-term survival have been reported.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/87458">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1677730"><div><strong>Leukoencephalopathy, acute reversible, with increased urinary alpha-ketoglutarate</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1677730</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5193068</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Acute reversible leukoencephalopathy with increased urinary alpha-ketoglutarate (ARLIAK) is an autosomal recessive disorder characterized by acute reversible neurologic deterioration in the context of a febrile illness. The disorder is associated with transient leukoencephalopathy on brain imaging concurrent with the acute episode, as well as persistently increased excretion of dicarboxylic acids, particularly alpha-ketoglutarate (summary by Dewulf et al., 2019).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1677730">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1748100"><div><strong>Mitochondrial complex 4 deficiency, nuclear type 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1748100</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5436683</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Mitochondrial complex IV deficiency nuclear type 4 (MC4DN4) is an autosomal recessive multisystem metabolic disorder characterized by the onset of symptoms in infancy. Affected individuals show hypotonia, failure to thrive, and neurologic distress. Additional features include hepatomegaly, hepatic steatosis, increased serum lactate, and metabolic acidosis. Some patients may develop hypertrophic cardiomyopathy. Patient tissues show decreased levels and activity of mitochondrial respiratory complex IV. Death usually occurs in infancy (summary by Valnot et al., 2000 and Stiburek et al., 2009). For a discussion of genetic heterogeneity of mitochondrial complex IV (cytochrome c oxidase) deficiency, see 220110.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1748100">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1802316"><div><strong>D,L-2-hydroxyglutaric aciduria</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1802316</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5574940</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Combined D-2- and L-2-hydroxyglutaric aciduria (D2L2AD) is an autosomal recessive neurometabolic disorder characterized by neonatal-onset encephalopathy with severe muscular weakness, intractable seizures, respiratory distress, and lack of psychomotor development resulting in early death. Brain imaging shows abnormalities including enlarged ventricles, delayed myelination, and germinal layer cysts (Muntau et al., 2000). See also isolated L-2-hydroxyglutaric aciduria (236792) and isolated D-2-hydroxyglutaric aciduria (see 600721).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1802316">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1802316" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">D,L-2-hydroxyglutaric aciduria</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_87458" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Fumarase deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1677730" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Leukoencephalopathy, acute reversible, with increased urinary alpha-ketoglutarate</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1748100" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Mitochondrial complex 4 deficiency, nuclear type 4</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39642943">The role of urine metabolomics in the diagnosis and management of adult and pediatric Crohn's disease and ulcerative colitis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Baskaran K,
|
||
Moshkovich M,
|
||
Hart L,
|
||
Shah N,
|
||
Chowdhury F,
|
||
Shanmuganathan M,
|
||
Britz-McKibbin P,
|
||
Pai N</span><br />
|
||
<span class="medgenPMjournal">Biomarkers</span>
|
||
2025 Feb;30(1):104-113.
|
||
Epub 2024 Dec 11
|
||
doi: 10.1080/1354750X.2024.2438734.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39642943" target="_blank">39642943</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28246924">JSA guideline for the management of malignant hyperthermia crisis 2016.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Safety Committee of Japanese Society of Anesthesiologists</span><br />
|
||
<span class="medgenPMjournal">J Anesth</span>
|
||
2017 Apr;31(2):307-317.
|
||
Epub 2017 Feb 28
|
||
doi: 10.1007/s00540-016-2305-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28246924" target="_blank">28246924</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22424739">Biochemical, molecular, and clinical characteristics of children with short chain acyl-CoA dehydrogenase deficiency detected by newborn screening in California.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gallant NM,
|
||
Leydiker K,
|
||
Tang H,
|
||
Feuchtbaum L,
|
||
Lorey F,
|
||
Puckett R,
|
||
Deignan JL,
|
||
Neidich J,
|
||
Dorrani N,
|
||
Chang E,
|
||
Barshop BA,
|
||
Cederbaum SD,
|
||
Abdenur JE,
|
||
Wang RY</span><br />
|
||
<span class="medgenPMjournal">Mol Genet Metab</span>
|
||
2012 May;106(1):55-61.
|
||
Epub 2012 Feb 9
|
||
doi: 10.1016/j.ymgme.2012.02.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22424739" target="_blank">22424739</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(increased%20urine%20succinate%20level)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (6)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/31504671">Metabolomic Urine Profile: Searching for New Biomarkers of SDHx-Associated Pheochromocytomas and Paragangliomas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Martins RG,
|
||
Gonçalves LG,
|
||
Cunha N,
|
||
Bugalho MJ</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2019 Nov 1;104(11):5467-5477.
|
||
doi: 10.1210/jc.2019-01101.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31504671" target="_blank">31504671</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20628440">Sorting out the spinning of autism: heavy metals and the question of incidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Desoto MC,
|
||
Hitlan RT</span><br />
|
||
<span class="medgenPMjournal">Acta Neurobiol Exp (Wars)</span>
|
||
2010;70(2):165-76.
|
||
doi: 10.55782/ane-2010-1788.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20628440" target="_blank">20628440</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20171655">Urinary cytokines and renal Doppler study in Kawasaki disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wu JM,
|
||
Chiou YY,
|
||
Hung WP,
|
||
Chiu NT,
|
||
Chen MJ,
|
||
Wang JN</span><br />
|
||
<span class="medgenPMjournal">J Pediatr</span>
|
||
2010 May;156(5):792-7.
|
||
Epub 2010 Feb 20
|
||
doi: 10.1016/j.jpeds.2009.11.046.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20171655" target="_blank">20171655</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16356027">Toxicokinetics of mercury elimination by succimer in twin toddlers.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fayez I,
|
||
Paiva M,
|
||
Thompson M,
|
||
Verjee Z,
|
||
Koren G</span><br />
|
||
<span class="medgenPMjournal">Paediatr Drugs</span>
|
||
2005;7(6):397-400.
|
||
doi: 10.2165/00148581-200507060-00008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16356027" target="_blank">16356027</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2845043">Dose-response study of oral 2,3-dimercaptosuccinic acid in children with elevated blood lead concentrations.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Graziano JH,
|
||
Lolacono NJ,
|
||
Meyer P</span><br />
|
||
<span class="medgenPMjournal">J Pediatr</span>
|
||
1988 Oct;113(4):751-7.
|
||
doi: 10.1016/s0022-3476(88)80396-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2845043" target="_blank">2845043</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Increased%20urine%20succinate%20level%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (56)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/22395524">Carnitine deficiency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Răşanu T,
|
||
Mehedinţi-Hâncu M,
|
||
Alexianu M,
|
||
Mehedinţi T,
|
||
Gheorghe E,
|
||
Damian I</span><br />
|
||
<span class="medgenPMjournal">Rom J Morphol Embryol</span>
|
||
2012;53(1):203-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22395524" target="_blank">22395524</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20628440">Sorting out the spinning of autism: heavy metals and the question of incidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Desoto MC,
|
||
Hitlan RT</span><br />
|
||
<span class="medgenPMjournal">Acta Neurobiol Exp (Wars)</span>
|
||
2010;70(2):165-76.
|
||
doi: 10.55782/ane-2010-1788.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20628440" target="_blank">20628440</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17719172">ALS and mercury intoxication: a relationship?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Praline J,
|
||
Guennoc AM,
|
||
Limousin N,
|
||
Hallak H,
|
||
de Toffol B,
|
||
Corcia P</span><br />
|
||
<span class="medgenPMjournal">Clin Neurol Neurosurg</span>
|
||
2007 Dec;109(10):880-3.
|
||
Epub 2007 Aug 23
|
||
doi: 10.1016/j.clineuro.2007.07.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17719172" target="_blank">17719172</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16097921">Phaeochromocytoma: current concepts.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Alderazi Y,
|
||
Yeh MW,
|
||
Robinson BG,
|
||
Benn DE,
|
||
Sywak MS,
|
||
Learoyd DL,
|
||
Delbridge LW,
|
||
Sidhu SB</span><br />
|
||
<span class="medgenPMjournal">Med J Aust</span>
|
||
2005 Aug 15;183(4):201-4.
|
||
doi: 10.5694/j.1326-5377.2005.tb06997.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16097921" target="_blank">16097921</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2845043">Dose-response study of oral 2,3-dimercaptosuccinic acid in children with elevated blood lead concentrations.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Graziano JH,
|
||
Lolacono NJ,
|
||
Meyer P</span><br />
|
||
<span class="medgenPMjournal">J Pediatr</span>
|
||
1988 Oct;113(4):751-7.
|
||
doi: 10.1016/s0022-3476(88)80396-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2845043" target="_blank">2845043</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Increased%20urine%20succinate%20level%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (54)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/28712602">Anaplerotic therapy in propionic acidemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Longo N,
|
||
Price LB,
|
||
Gappmaier E,
|
||
Cantor NL,
|
||
Ernst SL,
|
||
Bailey C,
|
||
Pasquali M</span><br />
|
||
<span class="medgenPMjournal">Mol Genet Metab</span>
|
||
2017 Sep;122(1-2):51-59.
|
||
Epub 2017 Jul 12
|
||
doi: 10.1016/j.ymgme.2017.07.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28712602" target="_blank">28712602</a><a href="/pmc/articles/PMC5612888" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17719172">ALS and mercury intoxication: a relationship?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Praline J,
|
||
Guennoc AM,
|
||
Limousin N,
|
||
Hallak H,
|
||
de Toffol B,
|
||
Corcia P</span><br />
|
||
<span class="medgenPMjournal">Clin Neurol Neurosurg</span>
|
||
2007 Dec;109(10):880-3.
|
||
Epub 2007 Aug 23
|
||
doi: 10.1016/j.clineuro.2007.07.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17719172" target="_blank">17719172</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16356027">Toxicokinetics of mercury elimination by succimer in twin toddlers.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fayez I,
|
||
Paiva M,
|
||
Thompson M,
|
||
Verjee Z,
|
||
Koren G</span><br />
|
||
<span class="medgenPMjournal">Paediatr Drugs</span>
|
||
2005;7(6):397-400.
|
||
doi: 10.2165/00148581-200507060-00008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16356027" target="_blank">16356027</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7605532">Pediatric arsenic ingestion.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cullen NM,
|
||
Wolf LR,
|
||
St Clair D</span><br />
|
||
<span class="medgenPMjournal">Am J Emerg Med</span>
|
||
1995 Jul;13(4):432-5.
|
||
doi: 10.1016/0735-6757(95)90133-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7605532" target="_blank">7605532</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2845043">Dose-response study of oral 2,3-dimercaptosuccinic acid in children with elevated blood lead concentrations.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Graziano JH,
|
||
Lolacono NJ,
|
||
Meyer P</span><br />
|
||
<span class="medgenPMjournal">J Pediatr</span>
|
||
1988 Oct;113(4):751-7.
|
||
doi: 10.1016/s0022-3476(88)80396-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2845043" target="_blank">2845043</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Increased%20urine%20succinate%20level%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (50)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38862963">Clinical features and ALDH5A1 gene findings in 13 Chinese cases with succinic semialdehyde dehydrogenase deficiency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dong H,
|
||
Ma X,
|
||
Chen Z,
|
||
Zhang H,
|
||
Song J,
|
||
Jin Y,
|
||
Li M,
|
||
Lu M,
|
||
He R,
|
||
Zhang Y,
|
||
Yang Y</span><br />
|
||
<span class="medgenPMjournal">BMC Med Genomics</span>
|
||
2024 Jun 11;17(1):158.
|
||
doi: 10.1186/s12920-024-01925-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38862963" target="_blank">38862963</a><a href="/pmc/articles/PMC11165735" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31319406">Systemic Succinate, Hypoxia-Inducible Factor-1 Alpha, and IL-1β Gene Expression in Autosomal Dominant Polycystic Kidney Disease with and without Hypertension.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kocyigit I,
|
||
Taheri S,
|
||
Eroglu E,
|
||
Sener EF,
|
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Zararsız G,
|
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Uzun I,
|
||
Tufan E,
|
||
Mehmetbeyoglu E,
|
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Korkmaz Bayramov K,
|
||
Sipahioglu MH,
|
||
Ozkul Y,
|
||
Tokgoz B,
|
||
Oymak O,
|
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Axelsson J</span><br />
|
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<span class="medgenPMjournal">Cardiorenal Med</span>
|
||
2019;9(6):370-381.
|
||
Epub 2019 Jul 18
|
||
doi: 10.1159/000500478.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31319406" target="_blank">31319406</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26577083">Metabolomic profiling of urinary changes in mice with monosodium glutamate-induced obesity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pelantová H,
|
||
Bártová S,
|
||
Anýž J,
|
||
Holubová M,
|
||
Železná B,
|
||
Maletínská L,
|
||
Novák D,
|
||
Lacinová Z,
|
||
Šulc M,
|
||
Haluzík M,
|
||
Kuzma M</span><br />
|
||
<span class="medgenPMjournal">Anal Bioanal Chem</span>
|
||
2016 Jan;408(2):567-78.
|
||
Epub 2015 Nov 17
|
||
doi: 10.1007/s00216-015-9133-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26577083" target="_blank">26577083</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23973519">Urinary NGF, TGF-β1, TIMP-2 and bladder wall thickness predict neurourological findings in children with myelodysplasia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Şekerci ÇA,
|
||
Işbilen B,
|
||
Işman F,
|
||
Akbal C,
|
||
Şimşek F,
|
||
Tarcan T</span><br />
|
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<span class="medgenPMjournal">J Urol</span>
|
||
2014 Jan;191(1):199-205.
|
||
Epub 2013 Aug 21
|
||
doi: 10.1016/j.juro.2013.08.025.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23973519" target="_blank">23973519</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17719172">ALS and mercury intoxication: a relationship?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Praline J,
|
||
Guennoc AM,
|
||
Limousin N,
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Hallak H,
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||
de Toffol B,
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Corcia P</span><br />
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<span class="medgenPMjournal">Clin Neurol Neurosurg</span>
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2007 Dec;109(10):880-3.
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||
Epub 2007 Aug 23
|
||
doi: 10.1016/j.clineuro.2007.07.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17719172" target="_blank">17719172</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Increased%20urine%20succinate%20level%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (32)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39642943">The role of urine metabolomics in the diagnosis and management of adult and pediatric Crohn's disease and ulcerative colitis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Baskaran K,
|
||
Moshkovich M,
|
||
Hart L,
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||
Shah N,
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||
Chowdhury F,
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||
Shanmuganathan M,
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||
Britz-McKibbin P,
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||
Pai N</span><br />
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<span class="medgenPMjournal">Biomarkers</span>
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||
2025 Feb;30(1):104-113.
|
||
Epub 2024 Dec 11
|
||
doi: 10.1080/1354750X.2024.2438734.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39642943" target="_blank">39642943</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35328641">Evaluation of Metabolic Changes in Acute Intermittent Porphyria Patients by Targeted Metabolomics.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gomez-Gomez A,
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||
Aguilera P,
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||
Langohr K,
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||
Casals G,
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||
Pavon C,
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||
Marcos J,
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||
To-Figueras J,
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||
Pozo OJ</span><br />
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||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2022 Mar 16;23(6)
|
||
doi: 10.3390/ijms23063219.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35328641" target="_blank">35328641</a><a href="/pmc/articles/PMC8950560" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
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<div class="nl"><a target="_blank" href="/pubmed/28712602">Anaplerotic therapy in propionic acidemia.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Longo N,
|
||
Price LB,
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||
Gappmaier E,
|
||
Cantor NL,
|
||
Ernst SL,
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||
Bailey C,
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||
Pasquali M</span><br />
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||
<span class="medgenPMjournal">Mol Genet Metab</span>
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||
2017 Sep;122(1-2):51-59.
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||
Epub 2017 Jul 12
|
||
doi: 10.1016/j.ymgme.2017.07.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28712602" target="_blank">28712602</a><a href="/pmc/articles/PMC5612888" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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<div class="nl"><a target="_blank" href="/pubmed/16356027">Toxicokinetics of mercury elimination by succimer in twin toddlers.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Fayez I,
|
||
Paiva M,
|
||
Thompson M,
|
||
Verjee Z,
|
||
Koren G</span><br />
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||
<span class="medgenPMjournal">Paediatr Drugs</span>
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||
2005;7(6):397-400.
|
||
doi: 10.2165/00148581-200507060-00008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16356027" target="_blank">16356027</a></div>
|
||
|
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<div class="nl"><a target="_blank" href="/pubmed/12829002">Effect of valproic acid on the urinary metabolic profile of a patient with succinic semialdehyde dehydrogenase deficiency.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Shinka T,
|
||
Ohfu M,
|
||
Hirose S,
|
||
Kuhara T</span><br />
|
||
<span class="medgenPMjournal">J Chromatogr B Analyt Technol Biomed Life Sci</span>
|
||
2003 Jul 15;792(1):99-106.
|
||
doi: 10.1016/s1570-0232(03)00276-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12829002" target="_blank">12829002</a></div>
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