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<meta name="keywords" content="C5239111, metastatic her2 negative breast adenocarcinoma, metastatic her2 negative breast carcinoma, metastatic her2-negative breast carcinoma, neoplastic process, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A HER2-negative breast adenocarcinoma that has spread to another anatomic site." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
UID=1709546
ConceptID=C5239111
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Metastatic HER2-Negative Breast Carcinoma</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1709546</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5239111</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Metastatic HER2 Negative Breast Adenocarcinoma; Metastatic HER2 Negative Breast Carcinoma</td></tr>
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">A HER2-negative breast adenocarcinoma that has spread to another anatomic site. [from <a title="NCI Thesaurus" href="http://ncit.nci.nih.gov" class="defSource" target="_blank">NCI</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Metastatic HER2-Negative Breast Carcinoma</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/10294" ref="tree=MeSH" title="MedGen record for Neoplasm">Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/277963" ref="tree=MeSH" title="MedGen record for Epithelial neoplasm">Epithelial neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/2867" ref="tree=MeSH" title="MedGen record for Carcinoma">Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/122" ref="tree=MeSH" title="MedGen record for Adenocarcinoma">Adenocarcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/167809" ref="tree=MeSH" title="MedGen record for Breast adenocarcinoma">Breast adenocarcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1714400" ref="tree=MeSH" title="MedGen record for HER2-Negative Breast Carcinoma">HER2-Negative Breast Carcinoma</a></span><ul><li><span class="matched_ds">Metastatic HER2-Negative Breast Carcinoma</span><ul><li><span class="TLline"><a href="/medgen/1713969" ref="tree=MeSH" title="MedGen record for Advanced HER2-Negative Breast Carcinoma">Advanced HER2-Negative Breast Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1791413" ref="tree=MeSH" title="MedGen record for Locally Advanced HER2-Negative Breast Carcinoma">Locally Advanced HER2-Negative Breast Carcinoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/38245458">CDK4/6 inhibitors in the treatment of metastatic breast cancer: Focus on toxicity and safety.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wekking D,
Lambertini M,
Dessì M,
Denaro N,
Bardanzellu F,
Garrone O,
Scartozzi M,
Solinas C</span><br />
<span class="medgenPMjournal">Semin Oncol</span>
2023 Dec;50(6):131-139.
Epub 2024 Jan 13
doi: 10.1053/j.seminoncol.2024.01.002.
<span class="bold">PMID: </span><a href="/pubmed/38245458" target="_blank">38245458</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34324367">Endocrine Treatment and Targeted Therapy for Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer: ASCO Guideline Update.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Burstein HJ,
Somerfield MR,
Barton DL,
Dorris A,
Fallowfield LJ,
Jain D,
Johnston SRD,
Korde LA,
Litton JK,
Macrae ER,
Peterson LL,
Vikas P,
Yung RL,
Rugo HS</span><br />
<span class="medgenPMjournal">J Clin Oncol</span>
2021 Dec 10;39(35):3959-3977.
Epub 2021 Jul 29
doi: 10.1200/JCO.21.01392.
<span class="bold">PMID: </span><a href="/pubmed/34324367" target="_blank">34324367</a><a href="/pmc/articles/PMC8659999" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33710534">An Overview of PARP Inhibitors for the Treatment of Breast Cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cortesi L,
Rugo HS,
Jackisch C</span><br />
<span class="medgenPMjournal">Target Oncol</span>
2021 May;16(3):255-282.
Epub 2021 Mar 12
doi: 10.1007/s11523-021-00796-4.
<span class="bold">PMID: </span><a href="/pubmed/33710534" target="_blank">33710534</a><a href="/pmc/articles/PMC8105250" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(metastatic%20her2-negative%20breast%20carcinoma)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (200)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/37387213">TROPION-Breast01: Datopotamab deruxtecan vs chemotherapy in pre-treated inoperable or metastatic HR+/HER2- breast cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bardia A,
Jhaveri K,
Kalinsky K,
Pernas S,
Tsurutani J,
Xu B,
Hamilton E,
Im SA,
Nowecki Z,
Sohn J,
Laurentiis M,
Jañez NM,
Adamo B,
Lee KS,
Jung KH,
Rubovszky G,
Tseng LM,
Lu YS,
Yuan Y,
Maxwell MJ,
Haddad V,
Khan SS,
Rugo HS,
Pistilli B</span><br />
<span class="medgenPMjournal">Future Oncol</span>
2024 Mar;20(8):423-436.
Epub 2023 Jun 30
doi: 10.2217/fon-2023-0188.
<span class="bold">PMID: </span><a href="/pubmed/37387213" target="_blank">37387213</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34458944">Male breast cancer: an update.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Fox S,
Speirs V,
Shaaban AM</span><br />
<span class="medgenPMjournal">Virchows Arch</span>
2022 Jan;480(1):85-93.
Epub 2021 Aug 30
doi: 10.1007/s00428-021-03190-7.
<span class="bold">PMID: </span><a href="/pubmed/34458944" target="_blank">34458944</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28578601">Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Robson M,
Im SA,
Senkus E,
Xu B,
Domchek SM,
Masuda N,
Delaloge S,
Li W,
Tung N,
Armstrong A,
Wu W,
Goessl C,
Runswick S,
Conte P</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2017 Aug 10;377(6):523-533.
Epub 2017 Jun 4
doi: 10.1056/NEJMoa1706450.
<span class="bold">PMID: </span><a href="/pubmed/28578601" target="_blank">28578601</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28564564">Adjuvant Capecitabine for Breast Cancer after Preoperative Chemotherapy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Masuda N,
Lee SJ,
Ohtani S,
Im YH,
Lee ES,
Yokota I,
Kuroi K,
Im SA,
Park BW,
Kim SB,
Yanagita Y,
Ohno S,
Takao S,
Aogi K,
Iwata H,
Jeong J,
Kim A,
Park KH,
Sasano H,
Ohashi Y,
Toi M</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2017 Jun 1;376(22):2147-2159.
doi: 10.1056/NEJMoa1612645.
<span class="bold">PMID: </span><a href="/pubmed/28564564" target="_blank">28564564</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26253814">Clinical implications of the intrinsic molecular subtypes of breast cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Prat A,
Pineda E,
Adamo B,
Galván P,
Fernández A,
Gaba L,
Díez M,
Viladot M,
Arance A,
Muñoz M</span><br />
<span class="medgenPMjournal">Breast</span>
2015 Nov;24 Suppl 2:S26-35.
Epub 2015 Aug 5
doi: 10.1016/j.breast.2015.07.008.
<span class="bold">PMID: </span><a href="/pubmed/26253814" target="_blank">26253814</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Metastatic%20HER2-Negative%20Breast%20Carcinoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (773)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/38388873">Capivasertib: First Approval.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Shirley M</span><br />
<span class="medgenPMjournal">Drugs</span>
2024 Mar;84(3):337-346.
doi: 10.1007/s40265-024-01998-6.
<span class="bold">PMID: </span><a href="/pubmed/38388873" target="_blank">38388873</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35029776">Updates on breast biomarkers.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Najjar S,
Allison KH</span><br />
<span class="medgenPMjournal">Virchows Arch</span>
2022 Jan;480(1):163-176.
Epub 2022 Jan 14
doi: 10.1007/s00428-022-03267-x.
<span class="bold">PMID: </span><a href="/pubmed/35029776" target="_blank">35029776</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34458944">Male breast cancer: an update.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Fox S,
Speirs V,
Shaaban AM</span><br />
<span class="medgenPMjournal">Virchows Arch</span>
2022 Jan;480(1):85-93.
Epub 2021 Aug 30
doi: 10.1007/s00428-021-03190-7.
<span class="bold">PMID: </span><a href="/pubmed/34458944" target="_blank">34458944</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28882552">Prognostic and predictive biomarkers in breast cancer: Past, present and future.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Nicolini A,
Ferrari P,
Duffy MJ</span><br />
<span class="medgenPMjournal">Semin Cancer Biol</span>
2018 Oct;52(Pt 1):56-73.
Epub 2017 Sep 4
doi: 10.1016/j.semcancer.2017.08.010.
<span class="bold">PMID: </span><a href="/pubmed/28882552" target="_blank">28882552</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26947331">Fulvestrant plus palbociclib versus fulvestrant plus placebo for treatment of hormone-receptor-positive, HER2-negative metastatic breast cancer that progressed on previous endocrine therapy (PALOMA-3): final analysis of the multicentre, double-blind, phase 3 randomised controlled trial.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cristofanilli M,
Turner NC,
Bondarenko I,
Ro J,
Im SA,
Masuda N,
Colleoni M,
DeMichele A,
Loi S,
Verma S,
Iwata H,
Harbeck N,
Zhang K,
Theall KP,
Jiang Y,
Bartlett CH,
Koehler M,
Slamon D</span><br />
<span class="medgenPMjournal">Lancet Oncol</span>
2016 Apr;17(4):425-439.
Epub 2016 Mar 3
doi: 10.1016/S1470-2045(15)00613-0.
<span class="bold">PMID: </span><a href="/pubmed/26947331" target="_blank">26947331</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Metastatic%20HER2-Negative%20Breast%20Carcinoma%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (410)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/37387213">TROPION-Breast01: Datopotamab deruxtecan vs chemotherapy in pre-treated inoperable or metastatic HR+/HER2- breast cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bardia A,
Jhaveri K,
Kalinsky K,
Pernas S,
Tsurutani J,
Xu B,
Hamilton E,
Im SA,
Nowecki Z,
Sohn J,
Laurentiis M,
Jañez NM,
Adamo B,
Lee KS,
Jung KH,
Rubovszky G,
Tseng LM,
Lu YS,
Yuan Y,
Maxwell MJ,
Haddad V,
Khan SS,
Rugo HS,
Pistilli B</span><br />
<span class="medgenPMjournal">Future Oncol</span>
2024 Mar;20(8):423-436.
Epub 2023 Jun 30
doi: 10.2217/fon-2023-0188.
<span class="bold">PMID: </span><a href="/pubmed/37387213" target="_blank">37387213</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30345906">Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Schmid P,
Adams S,
Rugo HS,
Schneeweiss A,
Barrios CH,
Iwata H,
Diéras V,
Hegg R,
Im SA,
Shaw Wright G,
Henschel V,
Molinero L,
Chui SY,
Funke R,
Husain A,
Winer EP,
Loi S,
Emens LA;
IMpassion130 Trial Investigators</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2018 Nov 29;379(22):2108-2121.
Epub 2018 Oct 20
doi: 10.1056/NEJMoa1809615.
<span class="bold">PMID: </span><a href="/pubmed/30345906" target="_blank">30345906</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28578601">Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Robson M,
Im SA,
Senkus E,
Xu B,
Domchek SM,
Masuda N,
Delaloge S,
Li W,
Tung N,
Armstrong A,
Wu W,
Goessl C,
Runswick S,
Conte P</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2017 Aug 10;377(6):523-533.
Epub 2017 Jun 4
doi: 10.1056/NEJMoa1706450.
<span class="bold">PMID: </span><a href="/pubmed/28578601" target="_blank">28578601</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28564564">Adjuvant Capecitabine for Breast Cancer after Preoperative Chemotherapy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Masuda N,
Lee SJ,
Ohtani S,
Im YH,
Lee ES,
Yokota I,
Kuroi K,
Im SA,
Park BW,
Kim SB,
Yanagita Y,
Ohno S,
Takao S,
Aogi K,
Iwata H,
Jeong J,
Kim A,
Park KH,
Sasano H,
Ohashi Y,
Toi M</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2017 Jun 1;376(22):2147-2159.
doi: 10.1056/NEJMoa1612645.
<span class="bold">PMID: </span><a href="/pubmed/28564564" target="_blank">28564564</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26253814">Clinical implications of the intrinsic molecular subtypes of breast cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Prat A,
Pineda E,
Adamo B,
Galván P,
Fernández A,
Gaba L,
Díez M,
Viladot M,
Arance A,
Muñoz M</span><br />
<span class="medgenPMjournal">Breast</span>
2015 Nov;24 Suppl 2:S26-35.
Epub 2015 Aug 5
doi: 10.1016/j.breast.2015.07.008.
<span class="bold">PMID: </span><a href="/pubmed/26253814" target="_blank">26253814</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Metastatic%20HER2-Negative%20Breast%20Carcinoma%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1094)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/37387213">TROPION-Breast01: Datopotamab deruxtecan vs chemotherapy in pre-treated inoperable or metastatic HR+/HER2- breast cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bardia A,
Jhaveri K,
Kalinsky K,
Pernas S,
Tsurutani J,
Xu B,
Hamilton E,
Im SA,
Nowecki Z,
Sohn J,
Laurentiis M,
Jañez NM,
Adamo B,
Lee KS,
Jung KH,
Rubovszky G,
Tseng LM,
Lu YS,
Yuan Y,
Maxwell MJ,
Haddad V,
Khan SS,
Rugo HS,
Pistilli B</span><br />
<span class="medgenPMjournal">Future Oncol</span>
2024 Mar;20(8):423-436.
Epub 2023 Jun 30
doi: 10.2217/fon-2023-0188.
<span class="bold">PMID: </span><a href="/pubmed/37387213" target="_blank">37387213</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34458944">Male breast cancer: an update.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Fox S,
Speirs V,
Shaaban AM</span><br />
<span class="medgenPMjournal">Virchows Arch</span>
2022 Jan;480(1):85-93.
Epub 2021 Aug 30
doi: 10.1007/s00428-021-03190-7.
<span class="bold">PMID: </span><a href="/pubmed/34458944" target="_blank">34458944</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28968163">MONARCH 3: Abemaciclib As Initial Therapy for Advanced Breast Cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Goetz MP,
Toi M,
Campone M,
Sohn J,
Paluch-Shimon S,
Huober J,
Park IH,
Trédan O,
Chen SC,
Manso L,
Freedman OC,
Garnica Jaliffe G,
Forrester T,
Frenzel M,
Barriga S,
Smith IC,
Bourayou N,
Di Leo A</span><br />
<span class="medgenPMjournal">J Clin Oncol</span>
2017 Nov 10;35(32):3638-3646.
Epub 2017 Oct 2
doi: 10.1200/JCO.2017.75.6155.
<span class="bold">PMID: </span><a href="/pubmed/28968163" target="_blank">28968163</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28564564">Adjuvant Capecitabine for Breast Cancer after Preoperative Chemotherapy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Masuda N,
Lee SJ,
Ohtani S,
Im YH,
Lee ES,
Yokota I,
Kuroi K,
Im SA,
Park BW,
Kim SB,
Yanagita Y,
Ohno S,
Takao S,
Aogi K,
Iwata H,
Jeong J,
Kim A,
Park KH,
Sasano H,
Ohashi Y,
Toi M</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2017 Jun 1;376(22):2147-2159.
doi: 10.1056/NEJMoa1612645.
<span class="bold">PMID: </span><a href="/pubmed/28564564" target="_blank">28564564</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25564897">Adjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tolaney SM,
Barry WT,
Dang CT,
Yardley DA,
Moy B,
Marcom PK,
Albain KS,
Rugo HS,
Ellis M,
Shapira I,
Wolff AC,
Carey LA,
Overmoyer BA,
Partridge AH,
Guo H,
Hudis CA,
Krop IE,
Burstein HJ,
Winer EP</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2015 Jan 8;372(2):134-41.
doi: 10.1056/NEJMoa1406281.
<span class="bold">PMID: </span><a href="/pubmed/25564897" target="_blank">25564897</a><a href="/pmc/articles/PMC4313867" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Metastatic%20HER2-Negative%20Breast%20Carcinoma%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (641)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/39476340">Inavolisib-Based Therapy in PIK3CA-Mutated Advanced Breast Cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Turner NC,
Im SA,
Saura C,
Juric D,
Loibl S,
Kalinsky K,
Schmid P,
Loi S,
Sunpaweravong P,
Musolino A,
Li H,
Zhang Q,
Nowecki Z,
Leung R,
Thanopoulou E,
Shankar N,
Lei G,
Stout TJ,
Hutchinson KE,
Schutzman JL,
Song C,
Jhaveri KL</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2024 Oct 31;391(17):1584-1596.
doi: 10.1056/NEJMoa2404625.
<span class="bold">PMID: </span><a href="/pubmed/39476340" target="_blank">39476340</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35029776">Updates on breast biomarkers.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Najjar S,
Allison KH</span><br />
<span class="medgenPMjournal">Virchows Arch</span>
2022 Jan;480(1):163-176.
Epub 2022 Jan 14
doi: 10.1007/s00428-022-03267-x.
<span class="bold">PMID: </span><a href="/pubmed/35029776" target="_blank">35029776</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31828441">PI3K Inhibitors in Breast Cancer Therapy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ellis H,
Ma CX</span><br />
<span class="medgenPMjournal">Curr Oncol Rep</span>
2019 Dec 11;21(12):110.
doi: 10.1007/s11912-019-0846-7.
<span class="bold">PMID: </span><a href="/pubmed/31828441" target="_blank">31828441</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29718092">Updated results from MONALEESA-2, a phase III trial of first-line ribociclib plus letrozole versus placebo plus letrozole in hormone receptor-positive, HER2-negative advanced breast cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hortobagyi GN,
Stemmer SM,
Burris HA,
Yap YS,
Sonke GS,
Paluch-Shimon S,
Campone M,
Petrakova K,
Blackwell KL,
Winer EP,
Janni W,
Verma S,
Conte P,
Arteaga CL,
Cameron DA,
Mondal S,
Su F,
Miller M,
Elmeliegy M,
Germa C,
O'Shaughnessy J</span><br />
<span class="medgenPMjournal">Ann Oncol</span>
2018 Jul 1;29(7):1541-1547.
doi: 10.1093/annonc/mdy155.
<span class="bold">PMID: </span><a href="/pubmed/29718092" target="_blank">29718092</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26253814">Clinical implications of the intrinsic molecular subtypes of breast cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Prat A,
Pineda E,
Adamo B,
Galván P,
Fernández A,
Gaba L,
Díez M,
Viladot M,
Arance A,
Muñoz M</span><br />
<span class="medgenPMjournal">Breast</span>
2015 Nov;24 Suppl 2:S26-35.
Epub 2015 Aug 5
doi: 10.1016/j.breast.2015.07.008.
<span class="bold">PMID: </span><a href="/pubmed/26253814" target="_blank">26253814</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Metastatic%20HER2-Negative%20Breast%20Carcinoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (655)</a></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="nl"><a target="_blank" href="/pubmed/37026492">Second-line Endocrine Therapy of Hormone Receptor-positive/HER2- negative Advanced Breast Cancer: A Systematic Review and Network Meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wang T,
Shen G,
Li J,
Huo X,
Wang M,
Liu Z,
Zhao F,
Ren D,
Zhao J</span><br />
<span class="medgenPMjournal">Curr Cancer Drug Targets</span>
2023;23(9):718-730.
doi: 10.2174/1568009623666230407101128.
<span class="bold">PMID: </span><a href="/pubmed/37026492" target="_blank">37026492</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34324367">Endocrine Treatment and Targeted Therapy for Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer: ASCO Guideline Update.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Burstein HJ,
Somerfield MR,
Barton DL,
Dorris A,
Fallowfield LJ,
Jain D,
Johnston SRD,
Korde LA,
Litton JK,
Macrae ER,
Peterson LL,
Vikas P,
Yung RL,
Rugo HS</span><br />
<span class="medgenPMjournal">J Clin Oncol</span>
2021 Dec 10;39(35):3959-3977.
Epub 2021 Jul 29
doi: 10.1200/JCO.21.01392.
<span class="bold">PMID: </span><a href="/pubmed/34324367" target="_blank">34324367</a><a href="/pmc/articles/PMC8659999" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33663223">CDK4/6 inhibitors in HR+/HER2- advanced/metastatic breast cancer: a systematic literature review of real-world evidence studies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Harbeck N,
Bartlett M,
Spurden D,
Hooper B,
Zhan L,
Rosta E,
Cameron C,
Mitra D,
Zhou A</span><br />
<span class="medgenPMjournal">Future Oncol</span>
2021 Jun;17(16):2107-2122.
Epub 2021 Mar 5
doi: 10.2217/fon-2020-1264.
<span class="bold">PMID: </span><a href="/pubmed/33663223" target="_blank">33663223</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31494037">Endocrine treatment versus chemotherapy in postmenopausal women with hormone receptor-positive, HER2-negative, metastatic breast cancer: a systematic review and network meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Giuliano M,
Schettini F,
Rognoni C,
Milani M,
Jerusalem G,
Bachelot T,
De Laurentiis M,
Thomas G,
De Placido P,
Arpino G,
De Placido S,
Cristofanilli M,
Giordano A,
Puglisi F,
Pistilli B,
Prat A,
Del Mastro L,
Venturini S,
Generali D</span><br />
<span class="medgenPMjournal">Lancet Oncol</span>
2019 Oct;20(10):1360-1369.
Epub 2019 Sep 4
doi: 10.1016/S1470-2045(19)30420-6.
<span class="bold">PMID: </span><a href="/pubmed/31494037" target="_blank">31494037</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26895472">mTOR inhibitors, a new era for metastatic luminal HER2-negative breast cancer? A systematic review and a meta-analysis of randomized trials.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Rotundo MS,
Galeano T,
Tassone P,
Tagliaferri P</span><br />
<span class="medgenPMjournal">Oncotarget</span>
2016 May 10;7(19):27055-66.
doi: 10.18632/oncotarget.7446.
<span class="bold">PMID: </span><a href="/pubmed/26895472" target="_blank">26895472</a><a href="/pmc/articles/PMC5053632" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Metastatic%20HER2-Negative%20Breast%20Carcinoma%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (43)</a></div></div>
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