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<!--
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||
UID=1700844
|
||
ConceptID=C5139167
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Severe infection</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1700844</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5139167</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Severe infections</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0032169">HP:0032169</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">A type of infection that is regarded as a sign of a pathological susceptibility to infection because of unusual severity or intensity of the infection. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Severe infection</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/867388" ref="tree=MeSH" title="MedGen record for Abnormality of the immune system">Abnormality of the immune system</a></span><ul><li><span class="TLline"><a href="/medgen/869194" ref="tree=MeSH" title="MedGen record for Abnormality of immune system physiology">Abnormality of immune system physiology</a></span><ul><li><span class="TLline"><a href="/medgen/1685049" ref="tree=MeSH" title="MedGen record for Unusual infection">Unusual infection</a></span><ul><li><span class="matched_ds">Severe infection</span><ul><li><span class="TLline"><a href="/medgen/321936" ref="tree=MeSH" title="MedGen record for Failure to thrive secondary to recurrent infections">Failure to thrive secondary to recurrent infections</a></span></li><li><span class="TLline"><a href="/medgen/1690100" ref="tree=MeSH" title="MedGen record for Persistent human papillomavirus infection">Persistent human papillomavirus infection</a></span></li><li><span class="TLline"><a href="/medgen/1692312" ref="tree=MeSH" title="MedGen record for Persistent viremia">Persistent viremia</a></span><ul><li><span class="TLline"><a href="/medgen/1696514" ref="tree=MeSH" title="MedGen record for Persistent CMV viremia">Persistent CMV viremia</a></span></li><li><span class="TLline"><a href="/medgen/767466" ref="tree=MeSH" title="MedGen record for Persistent EBV viremia">Persistent EBV viremia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1695503" ref="tree=MeSH" title="MedGen record for Prolonged need of intravenous antibiotic therapy">Prolonged need of intravenous antibiotic therapy</a></span></li><li><span class="TLline"><a href="/medgen/1688581" ref="tree=MeSH" title="MedGen record for Recurrent deep organ abscess formation">Recurrent deep organ abscess formation</a></span></li><li><span class="TLline"><a href="/medgen/1695771" ref="tree=MeSH" title="MedGen record for Severe norovirus infection">Severe norovirus infection</a></span></li><li><span class="TLline"><a href="/medgen/479058" ref="tree=MeSH" title="MedGen record for Severe viral infection">Severe viral infection</a></span><ul><li><span class="TLline"><a href="/medgen/1788598" ref="tree=MeSH" title="MedGen record for EBV meningitis">EBV meningitis</a></span></li><li><span class="TLline"><a href="/medgen/1648033" ref="tree=MeSH" title="MedGen record for Severe adenovirus infection">Severe adenovirus infection</a></span></li><li><span class="TLline"><a href="/medgen/1634535" ref="tree=MeSH" title="MedGen record for Severe cytomegalovirus infection">Severe cytomegalovirus infection</a></span></li><li><span class="TLline"><a href="/medgen/1635633" ref="tree=MeSH" title="MedGen record for Severe Epstein Barr virus infection">Severe Epstein Barr virus infection</a></span></li><li><span class="TLline"><a href="/medgen/1814393" ref="tree=MeSH" title="MedGen record for Severe influenza infection">Severe influenza infection</a></span></li><li><span class="TLline"><a href="/medgen/1637382" ref="tree=MeSH" title="MedGen record for Severe parainfluenza infection">Severe parainfluenza infection</a></span></li><li><span class="TLline"><a href="/medgen/1762704" ref="tree=MeSH" title="MedGen record for Severe SARS-CoV-2 infection">Severe SARS-CoV-2 infection</a></span></li><li><span class="TLline"><a href="/medgen/1688785" ref="tree=MeSH" title="MedGen record for Severe varicella zoster infection">Severe varicella zoster infection</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/116719" ref="tree=MeSH" title="MedGen record for Viral encephalitis">Viral encephalitis</a></span><ul><li><span class="TLline"><a href="/medgen/231027" ref="tree=MeSH" title="MedGen record for Acute hemorrhagic encephalitis">Acute hemorrhagic encephalitis</a></span><ul><li><span class="TLline"><a href="/medgen/4937" ref="tree=MeSH" title="MedGen record for Acute hemorrhagic leukoencephalitis">Acute hemorrhagic leukoencephalitis</a></span></li><li><span class="TLline"><a href="/medgen/1768646" ref="tree=MeSH" title="MedGen record for COVID-19-Associated Acute Hemorrhagic Necrotizing Encephalitis">COVID-19-Associated Acute Hemorrhagic Necrotizing Encephalitis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/83264" ref="tree=MeSH" title="MedGen record for Acute necrotizing encephalitis">Acute necrotizing encephalitis</a></span></li><li><span class="TLline"><a href="/medgen/1641610" ref="tree=MeSH" title="MedGen record for Acute necrotizing encephalopathy of childhood">Acute 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for Encephalitis lethargica">Encephalitis lethargica</a></span></li><li><span class="TLline"><a href="/medgen/572543" ref="tree=MeSH" title="MedGen record for Enteroviral encephalitis">Enteroviral encephalitis</a></span></li><li><span class="TLline"><a href="/medgen/1388276" ref="tree=MeSH" title="MedGen record for Hendra virus infection">Hendra virus infection</a></span></li><li><span class="TLline"><a href="/medgen/75794" ref="tree=MeSH" title="MedGen record for Herpes simplex encephalitis">Herpes simplex encephalitis</a></span></li><li><span class="TLline"><a href="/medgen/124361" ref="tree=MeSH" title="MedGen record for Kluver-Bucy syndrome">Kluver-Bucy syndrome</a></span></li><li><span class="TLline"><a href="/medgen/547309" ref="tree=MeSH" title="MedGen record for La Crosse encephalitis">La Crosse encephalitis</a></span></li><li><span class="TLline"><a href="/medgen/152945" ref="tree=MeSH" title="MedGen record for Mosquito-borne viral encephalitis">Mosquito-borne viral encephalitis</a></span></li><li><span class="TLline"><a href="/medgen/1636101" ref="tree=MeSH" title="MedGen record for Mycoplasma encephalitis">Mycoplasma encephalitis</a></span></li><li><span class="TLline"><a href="/medgen/728863" ref="tree=MeSH" title="MedGen record for Nipah virus disease">Nipah virus disease</a></span></li><li><span class="TLline"><a href="/medgen/102257" ref="tree=MeSH" title="MedGen record for Postvaricella encephalitis">Postvaricella encephalitis</a></span></li><li><span class="TLline"><a href="/medgen/7327" ref="tree=MeSH" title="MedGen record for Progressive multifocal leukoencephalopathy">Progressive multifocal leukoencephalopathy</a></span></li><li><span class="TLline"><a href="/medgen/726815" ref="tree=MeSH" title="MedGen record for Progressive rubella panencephalitis">Progressive rubella panencephalitis</a></span></li><li><span class="TLline"><a href="/medgen/52527" ref="tree=MeSH" title="MedGen record for Subacute sclerosing panencephalitis">Subacute sclerosing panencephalitis</a></span></li><li><span class="TLline"><a href="/medgen/155889" ref="tree=MeSH" title="MedGen record for West-Nile encephalitis">West-Nile encephalitis</a></span></li><li><span class="TLline"><a href="/medgen/57778" ref="tree=MeSH" title="MedGen record for Western equine encephalitis">Western equine encephalitis</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_83339"><div><strong>Insulin-dependent diabetes mellitus secretory diarrhea syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>83339</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0342288</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked) syndrome is characterized by systemic autoimmunity, typically beginning in the first year of life, which includes the triad of enteropathy (manifesting as malabsorption and watery diarrhea), endocrinopathy (most commonly type 1 insulin-dependent diabetes mellitus), and eczematous dermatitis. In addition to these manifestations, many children have other autoimmune phenomena including cytopenias, autoimmune hepatitis, nephropathy, lymphadenopathy, splenomegaly, alopecia, arthritis, and interstitial lung disease related to immune dysregulation. Fetal presentation of IPEX syndrome includes hydrops, echogenic bowel, skin desquamation, intrauterine growth deficiency, and fetal akinesia. Without aggressive immunosuppression or hematopoietic stem cell transplantation (HSCT), the majority of affected males will die within the first one to two years of life from metabolic derangements, severe malabsorption, or sepsis. Individuals with a milder phenotype have survived into the second or third decade of life, but this is uncommon.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/83339">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_337496"><div><strong>Syndromic X-linked intellectual disability Lubs type</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>337496</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1846058</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">MECP2 duplication syndrome is a severe neurodevelopmental disorder characterized by early-onset hypotonia, feeding difficulty, gastrointestinal manifestations including gastroesophageal reflux and constipation, delayed psychomotor development leading to severe intellectual disability, poor speech development, progressive spasticity, recurrent respiratory infections (in ~75% of affected individuals), and seizures (in ~50%). MECP2 duplication syndrome is 100% penetrant in males. Occasionally females have been described with a MECP2 duplication and a range of findings from mild intellectual disability to a phenotype similar to that seen in males. In addition to the core features, autistic behaviors, nonspecific neuroradiologic findings on brain MRI, mottled skin, and urogenital anomalies have been observed in several affected boys.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/337496">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1785594"><div><strong>WHIM syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1785594</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5543622</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">WHIM syndrome-2 (WHIMS2) is an autosomal recessive immunologic disorder characterized by chronic neutropenia and myelokathexis, which is impaired neutrophil mobilization from the bone marrow. Affected individuals have recurrent infections, usually bacterial (summary by Auer et al., 2014). In a review of WHIMS, Heusinkveld et al. (2019) noted that there is significant phenotypic variation among patients, such that some individuals may have an 'incomplete' form of the disorder in which 1 or more of the classic tetrad features are not present. In general, the WHIMS phenotype comprises a spectrum of manifestations with variable expressivity. For a discussion of genetic heterogeneity of WHIMS, see 193670.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1785594">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_83339" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Insulin-dependent diabetes mellitus secretory diarrhea syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_337496" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Syndromic X-linked intellectual disability Lubs type</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1785594" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">WHIM syndrome 2</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38395525">AGA Clinical Practice Guideline on Fecal Microbiota-Based Therapies for Select Gastrointestinal Diseases.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Peery AF,
|
||
Kelly CR,
|
||
Kao D,
|
||
Vaughn BP,
|
||
Lebwohl B,
|
||
Singh S,
|
||
Imdad A,
|
||
Altayar O;
|
||
AGA Clinical Guidelines Committee. Electronic address: clinicalpractice@gastro.org</span><br />
|
||
<span class="medgenPMjournal">Gastroenterology</span>
|
||
2024 Mar;166(3):409-434.
|
||
doi: 10.1053/j.gastro.2024.01.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38395525" target="_blank">38395525</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35078789">Dengue infection: Global importance, immunopathology and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kularatne SA,
|
||
Dalugama C</span><br />
|
||
<span class="medgenPMjournal">Clin Med (Lond)</span>
|
||
2022 Jan;22(1):9-13.
|
||
doi: 10.7861/clinmed.2021-0791.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35078789" target="_blank">35078789</a><a href="/pmc/articles/PMC8813012" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25344148">Inter-society consensus document on treatment and prevention of bronchiolitis in newborns and infants.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Baraldi E,
|
||
Lanari M,
|
||
Manzoni P,
|
||
Rossi GA,
|
||
Vandini S,
|
||
Rimini A,
|
||
Romagnoli C,
|
||
Colonna P,
|
||
Biondi A,
|
||
Biban P,
|
||
Chiamenti G,
|
||
Bernardini R,
|
||
Picca M,
|
||
Cappa M,
|
||
Magazzù G,
|
||
Catassi C,
|
||
Urbino AF,
|
||
Memo L,
|
||
Donzelli G,
|
||
Minetti C,
|
||
Paravati F,
|
||
Di Mauro G,
|
||
Festini F,
|
||
Esposito S,
|
||
Corsello G</span><br />
|
||
<span class="medgenPMjournal">Ital J Pediatr</span>
|
||
2014 Oct 24;40:65.
|
||
doi: 10.1186/1824-7288-40-65.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25344148" target="_blank">25344148</a><a href="/pmc/articles/PMC4364570" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22severe%20infection%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (292)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37277198">Kangaroo mother care for preterm or low birth weight infants: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sivanandan S,
|
||
Sankar MJ</span><br />
|
||
<span class="medgenPMjournal">BMJ Glob Health</span>
|
||
2023 Jun;8(6)
|
||
doi: 10.1136/bmjgh-2022-010728.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37277198" target="_blank">37277198</a><a href="/pmc/articles/PMC10254798" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36748315">Malice in Chains.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Osowicki J,
|
||
Nizet V</span><br />
|
||
<span class="medgenPMjournal">J Infect Dis</span>
|
||
2023 May 12;227(10):1117-1118.
|
||
doi: 10.1093/infdis/jiad035.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36748315" target="_blank">36748315</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35045034">The Epidemiology of COVID-19 in Pregnancy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Overton EE,
|
||
Goffman D,
|
||
Friedman AM</span><br />
|
||
<span class="medgenPMjournal">Clin Obstet Gynecol</span>
|
||
2022 Mar 1;65(1):110-122.
|
||
doi: 10.1097/GRF.0000000000000674.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35045034" target="_blank">35045034</a><a href="/pmc/articles/PMC8767915" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21979982">Non-cystic fibrosis bronchiectasis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Neves PC,
|
||
Guerra M,
|
||
Ponce P,
|
||
Miranda J,
|
||
Vouga L</span><br />
|
||
<span class="medgenPMjournal">Interact Cardiovasc Thorac Surg</span>
|
||
2011 Dec;13(6):619-25.
|
||
Epub 2011 Oct 6
|
||
doi: 10.1510/icvts.2011.284208.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21979982" target="_blank">21979982</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9056575">Traveler's diarrhea.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Larson SC</span><br />
|
||
<span class="medgenPMjournal">Emerg Med Clin North Am</span>
|
||
1997 Feb;15(1):179-89.
|
||
doi: 10.1016/s0733-8627(05)70290-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9056575" target="_blank">9056575</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Severe%20infection%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2344)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38506266">Listeria monocytogenes: the silent assassin.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fotopoulou ET,
|
||
Jenkins C,
|
||
Painset A,
|
||
Amar C</span><br />
|
||
<span class="medgenPMjournal">J Med Microbiol</span>
|
||
2024 Mar;73(3)
|
||
doi: 10.1099/jmm.0.001800.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38506266" target="_blank">38506266</a><a href="/pmc/articles/PMC10963902" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38204305">A scoping review of the management of acute mastoiditis in children: What is the best approach?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sarno LD,
|
||
Cammisa I,
|
||
Curatola A,
|
||
Pansini V,
|
||
Eftimiadi G,
|
||
Gatto A,
|
||
Chiaretti A</span><br />
|
||
<span class="medgenPMjournal">Turk J Pediatr</span>
|
||
2023;65(6):906-918.
|
||
doi: 10.24953/turkjped.2023.320.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38204305" target="_blank">38204305</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35078789">Dengue infection: Global importance, immunopathology and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kularatne SA,
|
||
Dalugama C</span><br />
|
||
<span class="medgenPMjournal">Clin Med (Lond)</span>
|
||
2022 Jan;22(1):9-13.
|
||
doi: 10.7861/clinmed.2021-0791.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35078789" target="_blank">35078789</a><a href="/pmc/articles/PMC8813012" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28671378">Acute and Chronic Paronychia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Leggit JC</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2017 Jul 1;96(1):44-51.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28671378" target="_blank">28671378</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21979982">Non-cystic fibrosis bronchiectasis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Neves PC,
|
||
Guerra M,
|
||
Ponce P,
|
||
Miranda J,
|
||
Vouga L</span><br />
|
||
<span class="medgenPMjournal">Interact Cardiovasc Thorac Surg</span>
|
||
2011 Dec;13(6):619-25.
|
||
Epub 2011 Oct 6
|
||
doi: 10.1510/icvts.2011.284208.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21979982" target="_blank">21979982</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Severe%20infection%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1485)</a></div><h3 class="subhead">Therapy</h3>
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<div class="nl"><a target="_blank" href="/pubmed/37277198">Kangaroo mother care for preterm or low birth weight infants: a systematic review and meta-analysis.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/35909965">Clinical Application and Influencing Factor Analysis of Metagenomic Next-Generation Sequencing (mNGS) in ICU Patients With Sepsis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Sun L,
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<div class="nl"><a target="_blank" href="/pubmed/34178920">Reinfection or Reactivation of Severe Acute Respiratory Syndrome Coronavirus 2: A Systematic Review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Tang X,
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<div class="nl"><a target="_blank" href="/pubmed/32275288">Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/26446604">Crawling with Virus: Translational Insights from a Neonatal Mouse Model on the Pathogenesis of Respiratory Syncytial Virus in Infants.</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Severe%20infection%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1218)</a></div></div>
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||
<div class="portlet mgSection" id="ID_104">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/37277198">Kangaroo mother care for preterm or low birth weight infants: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sivanandan S,
|
||
Sankar MJ</span><br />
|
||
<span class="medgenPMjournal">BMJ Glob Health</span>
|
||
2023 Jun;8(6)
|
||
doi: 10.1136/bmjgh-2022-010728.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37277198" target="_blank">37277198</a><a href="/pmc/articles/PMC10254798" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36931142">Prevalence and risk factor for long COVID in children and adolescents: A meta-analysis and systematic review.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Zheng YB,
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Zeng N,
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Yuan K,
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Tian SS,
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Yang YB,
|
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Gao N,
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Chen X,
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Zhang AY,
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Kondratiuk AL,
|
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Shi PP,
|
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Zhang F,
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Sun J,
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Yue JL,
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||
Lin X,
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Shi L,
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Lalvani A,
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Shi J,
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Bao YP,
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Lu L</span><br />
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<span class="medgenPMjournal">J Infect Public Health</span>
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2023 May;16(5):660-672.
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||
<span class="bold">PMID: </span><a href="/pubmed/36931142" target="_blank">36931142</a><a href="/pmc/articles/PMC9990879" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35536541">Antibiotic prophylaxis for preventing bacterial endocarditis following dental procedures.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Rutherford SJ,
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Glenny AM,
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Roberts G,
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Hooper L,
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Worthington HV</span><br />
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<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
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2022 May 10;5(5):CD003813.
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<span class="bold">PMID: </span><a href="/pubmed/35536541" target="_blank">35536541</a><a href="/pmc/articles/PMC9088886" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33722228">Clinical characteristics of severe neonatal enterovirus infection: a systematic review.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Zhang M,
|
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Wang H,
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Tang J,
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He Y,
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Xiong T,
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Li W,
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Qu Y,
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Mu D</span><br />
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<span class="medgenPMjournal">BMC Pediatr</span>
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<span class="bold">PMID: </span><a href="/pubmed/33722228" target="_blank">33722228</a><a href="/pmc/articles/PMC7958388" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27552521">Kangaroo mother care to reduce morbidity and mortality in low birthweight infants.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Conde-Agudelo A,
|
||
Díaz-Rossello JL</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
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2016 Aug 23;2016(8):CD002771.
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||
doi: 10.1002/14651858.CD002771.pub4.
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<span class="bold">PMID: </span><a href="/pubmed/27552521" target="_blank">27552521</a><a href="/pmc/articles/PMC6464509" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Severe%20infection%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (122)</a></div></div>
|
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|
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22severe%20infection%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Severe%20infection%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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