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1126 lines
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87 KiB
XML
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<!--
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UID=1698790
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ConceptID=C5206400
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Locally Advanced Unresectable Breast Carcinoma</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1698790</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5206400</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet_content ln">A breast carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection. [from <a title="NCI Thesaurus" href="http://ncit.nci.nih.gov" class="defSource" target="_blank">NCI</a>]</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Locally Advanced Unresectable Breast Carcinoma</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/235364" ref="tree=MeSH" title="MedGen record for Neoplasm by Special Category">Neoplasm by Special Category</a></span><ul><li><span class="TLline"><a href="/medgen/422476" ref="tree=MeSH" title="MedGen record for Metastatic neoplasm">Metastatic neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/422475" ref="tree=MeSH" title="MedGen record for Metastatic malignant neoplasm">Metastatic malignant neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/195665" ref="tree=MeSH" title="MedGen record for Locally Advanced Malignant Neoplasm">Locally Advanced Malignant Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/1665275" ref="tree=MeSH" title="MedGen record for Locally Advanced Carcinoma">Locally Advanced Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1703295" ref="tree=MeSH" title="MedGen record for Locally Advanced Breast Carcinoma">Locally Advanced Breast Carcinoma</a></span><ul><li><span class="matched_ds">Locally Advanced Unresectable Breast Carcinoma</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
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||
<div class="portlet mgSection" id="ID_105">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39013199">Expert consensus: Profiling and management of advanced or metastatic epithelial ovarian cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pierre ME,
|
||
Manneh R,
|
||
Hernández A,
|
||
Rodríguez J,
|
||
Fletcher AV,
|
||
Ramírez HM,
|
||
Niño OM,
|
||
Gómez DA,
|
||
Sanabria D,
|
||
Contreras F,
|
||
Pieschacón JR,
|
||
Calderón PH</span><br />
|
||
<span class="medgenPMjournal">Rev Colomb Obstet Ginecol</span>
|
||
2024 Jun 14;75(1)
|
||
doi: 10.18597/rcog.4094.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39013199" target="_blank">39013199</a><a href="/pmc/articles/PMC11210286" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38597713">Pembrolizumab plus chemotherapy for first-line treatment of advanced triple-negative breast cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Haiderali A,
|
||
Huang M,
|
||
Pan W,
|
||
Akers KG,
|
||
Maciel D,
|
||
Frederickson AM</span><br />
|
||
<span class="medgenPMjournal">Future Oncol</span>
|
||
2024;20(22):1587-1600.
|
||
Epub 2024 Apr 10
|
||
doi: 10.2217/fon-2023-0301.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38597713" target="_blank">38597713</a><a href="/pmc/articles/PMC11457619" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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||
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||
<div class="nl"><a target="_blank" href="/pubmed/32067545">Atezolizumab for the treatment of breast cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Reddy SM,
|
||
Carroll E,
|
||
Nanda R</span><br />
|
||
<span class="medgenPMjournal">Expert Rev Anticancer Ther</span>
|
||
2020 Mar;20(3):151-158.
|
||
Epub 2020 Feb 27
|
||
doi: 10.1080/14737140.2020.1732211.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32067545" target="_blank">32067545</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(locally%20advanced%20unresectable%20breast%20carcinoma)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (27)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34949142">Atezolizumab and pembrolizumab in triple-negative breast cancer: a meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Latif F,
|
||
Bint Abdul Jabbar H,
|
||
Malik H,
|
||
Sadaf H,
|
||
Sarfraz A,
|
||
Sarfraz Z,
|
||
Cherrez-Ojeda I</span><br />
|
||
<span class="medgenPMjournal">Expert Rev Anticancer Ther</span>
|
||
2022 Feb;22(2):229-235.
|
||
Epub 2022 Jan 24
|
||
doi: 10.1080/14737140.2022.2023011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34949142" target="_blank">34949142</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31786121">Atezolizumab plus nab-paclitaxel as first-line treatment for unresectable, locally advanced or metastatic triple-negative breast cancer (IMpassion130): updated efficacy results from a randomised, double-blind, placebo-controlled, phase 3 trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schmid P,
|
||
Rugo HS,
|
||
Adams S,
|
||
Schneeweiss A,
|
||
Barrios CH,
|
||
Iwata H,
|
||
Diéras V,
|
||
Henschel V,
|
||
Molinero L,
|
||
Chui SY,
|
||
Maiya V,
|
||
Husain A,
|
||
Winer EP,
|
||
Loi S,
|
||
Emens LA;
|
||
IMpassion130 Investigators</span><br />
|
||
<span class="medgenPMjournal">Lancet Oncol</span>
|
||
2020 Jan;21(1):44-59.
|
||
Epub 2019 Nov 27
|
||
doi: 10.1016/S1470-2045(19)30689-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31786121" target="_blank">31786121</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30345906">Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schmid P,
|
||
Adams S,
|
||
Rugo HS,
|
||
Schneeweiss A,
|
||
Barrios CH,
|
||
Iwata H,
|
||
Diéras V,
|
||
Hegg R,
|
||
Im SA,
|
||
Shaw Wright G,
|
||
Henschel V,
|
||
Molinero L,
|
||
Chui SY,
|
||
Funke R,
|
||
Husain A,
|
||
Winer EP,
|
||
Loi S,
|
||
Emens LA;
|
||
IMpassion130 Trial Investigators</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2018 Nov 29;379(22):2108-2121.
|
||
Epub 2018 Oct 20
|
||
doi: 10.1056/NEJMoa1809615.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30345906" target="_blank">30345906</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30069763">Everolimus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hasskarl J</span><br />
|
||
<span class="medgenPMjournal">Recent Results Cancer Res</span>
|
||
2018;211:101-123.
|
||
doi: 10.1007/978-3-319-91442-8_8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30069763" target="_blank">30069763</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28526536">Trastuzumab emtansine versus capecitabine plus lapatinib in patients with previously treated HER2-positive advanced breast cancer (EMILIA): a descriptive analysis of final overall survival results from a randomised, open-label, phase 3 trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Diéras V,
|
||
Miles D,
|
||
Verma S,
|
||
Pegram M,
|
||
Welslau M,
|
||
Baselga J,
|
||
Krop IE,
|
||
Blackwell K,
|
||
Hoersch S,
|
||
Xu J,
|
||
Green M,
|
||
Gianni L</span><br />
|
||
<span class="medgenPMjournal">Lancet Oncol</span>
|
||
2017 Jun;18(6):732-742.
|
||
Epub 2017 May 16
|
||
doi: 10.1016/S1470-2045(17)30312-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28526536" target="_blank">28526536</a><a href="/pmc/articles/PMC5531181" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Locally%20Advanced%20Unresectable%20Breast%20Carcinoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (57)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39013199">Expert consensus: Profiling and management of advanced or metastatic epithelial ovarian cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pierre ME,
|
||
Manneh R,
|
||
Hernández A,
|
||
Rodríguez J,
|
||
Fletcher AV,
|
||
Ramírez HM,
|
||
Niño OM,
|
||
Gómez DA,
|
||
Sanabria D,
|
||
Contreras F,
|
||
Pieschacón JR,
|
||
Calderón PH</span><br />
|
||
<span class="medgenPMjournal">Rev Colomb Obstet Ginecol</span>
|
||
2024 Jun 14;75(1)
|
||
doi: 10.18597/rcog.4094.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39013199" target="_blank">39013199</a><a href="/pmc/articles/PMC11210286" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38822227">Conversion surgery for initially unresectable locally advanced biliary tract cancer: A multicenter collaborative study conducted in Japan and Korea.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yabushita Y,
|
||
Park JS,
|
||
Yoon YS,
|
||
Ohtsuka M,
|
||
Kwon W,
|
||
Choi GH,
|
||
Imamura M,
|
||
Matsumoto I,
|
||
Mizuno S,
|
||
Matsuyama R,
|
||
Sakata J,
|
||
Hayashi H,
|
||
Takeda Y,
|
||
Katagiri S,
|
||
Sugawara T,
|
||
Kobayashi S,
|
||
Kawasaki Y,
|
||
Nagano H,
|
||
Murase K,
|
||
Kim HS,
|
||
Nah YW,
|
||
Jang JY,
|
||
Yamaue H,
|
||
Yoon DS,
|
||
Yamamoto M,
|
||
Choi D,
|
||
Nakamura M,
|
||
Kim KH,
|
||
Endo I</span><br />
|
||
<span class="medgenPMjournal">J Hepatobiliary Pancreat Sci</span>
|
||
2024 Jul;31(7):481-491.
|
||
Epub 2024 May 31
|
||
doi: 10.1002/jhbp.1437.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38822227" target="_blank">38822227</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38577882">Clinical efficacy of tumor organoid-guided cancer therapy for locally advanced unresectable or metastatic breast cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lin YY,
|
||
Gao HF,
|
||
Li H,
|
||
Hu Q,
|
||
Du BL,
|
||
Li S,
|
||
Xu FP,
|
||
Cheng MY,
|
||
Zou JC,
|
||
Zheng XX,
|
||
Zhu T,
|
||
Wang K</span><br />
|
||
<span class="medgenPMjournal">Int J Cancer</span>
|
||
2024 Aug 15;155(4):697-709.
|
||
Epub 2024 Apr 5
|
||
doi: 10.1002/ijc.34945.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38577882" target="_blank">38577882</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38431513">New Strategies for Locally Advanced Breast Cancer: A Review of Inflammatory Breast Cancer and Nonresponders.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Malhotra S,
|
||
Tadros AB</span><br />
|
||
<span class="medgenPMjournal">Clin Breast Cancer</span>
|
||
2024 Jun;24(4):301-309.
|
||
Epub 2024 Jan 21
|
||
doi: 10.1016/j.clbc.2024.01.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38431513" target="_blank">38431513</a><a href="/pmc/articles/PMC11338289" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32067545">Atezolizumab for the treatment of breast cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Reddy SM,
|
||
Carroll E,
|
||
Nanda R</span><br />
|
||
<span class="medgenPMjournal">Expert Rev Anticancer Ther</span>
|
||
2020 Mar;20(3):151-158.
|
||
Epub 2020 Feb 27
|
||
doi: 10.1080/14737140.2020.1732211.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32067545" target="_blank">32067545</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Locally%20Advanced%20Unresectable%20Breast%20Carcinoma%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (38)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34949142">Atezolizumab and pembrolizumab in triple-negative breast cancer: a meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Latif F,
|
||
Bint Abdul Jabbar H,
|
||
Malik H,
|
||
Sadaf H,
|
||
Sarfraz A,
|
||
Sarfraz Z,
|
||
Cherrez-Ojeda I</span><br />
|
||
<span class="medgenPMjournal">Expert Rev Anticancer Ther</span>
|
||
2022 Feb;22(2):229-235.
|
||
Epub 2022 Jan 24
|
||
doi: 10.1080/14737140.2022.2023011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34949142" target="_blank">34949142</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34219000">Primary results from IMpassion131, a double-blind, placebo-controlled, randomised phase III trial of first-line paclitaxel with or without atezolizumab for unresectable locally advanced/metastatic triple-negative breast cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Miles D,
|
||
Gligorov J,
|
||
André F,
|
||
Cameron D,
|
||
Schneeweiss A,
|
||
Barrios C,
|
||
Xu B,
|
||
Wardley A,
|
||
Kaen D,
|
||
Andrade L,
|
||
Semiglazov V,
|
||
Reinisch M,
|
||
Patel S,
|
||
Patre M,
|
||
Morales L,
|
||
Patel SL,
|
||
Kaul M,
|
||
Barata T,
|
||
O'Shaughnessy J;
|
||
IMpassion131 investigators</span><br />
|
||
<span class="medgenPMjournal">Ann Oncol</span>
|
||
2021 Aug;32(8):994-1004.
|
||
Epub 2021 Jul 1
|
||
doi: 10.1016/j.annonc.2021.05.801.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34219000" target="_blank">34219000</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33523233">Atezolizumab and nab-Paclitaxel in Advanced Triple-Negative Breast Cancer: Biomarker Evaluation of the IMpassion130 Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Emens LA,
|
||
Molinero L,
|
||
Loi S,
|
||
Rugo HS,
|
||
Schneeweiss A,
|
||
Diéras V,
|
||
Iwata H,
|
||
Barrios CH,
|
||
Nechaeva M,
|
||
Nguyen-Duc A,
|
||
Chui SY,
|
||
Husain A,
|
||
Winer EP,
|
||
Adams S,
|
||
Schmid P</span><br />
|
||
<span class="medgenPMjournal">J Natl Cancer Inst</span>
|
||
2021 Aug 2;113(8):1005-1016.
|
||
doi: 10.1093/jnci/djab004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33523233" target="_blank">33523233</a><a href="/pmc/articles/PMC8328980" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33015734">Pembrolizumab and atezolizumab in triple-negative breast cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kwapisz D</span><br />
|
||
<span class="medgenPMjournal">Cancer Immunol Immunother</span>
|
||
2021 Mar;70(3):607-617.
|
||
Epub 2020 Oct 5
|
||
doi: 10.1007/s00262-020-02736-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33015734" target="_blank">33015734</a><a href="/pmc/articles/PMC10992894" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30345906">Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schmid P,
|
||
Adams S,
|
||
Rugo HS,
|
||
Schneeweiss A,
|
||
Barrios CH,
|
||
Iwata H,
|
||
Diéras V,
|
||
Hegg R,
|
||
Im SA,
|
||
Shaw Wright G,
|
||
Henschel V,
|
||
Molinero L,
|
||
Chui SY,
|
||
Funke R,
|
||
Husain A,
|
||
Winer EP,
|
||
Loi S,
|
||
Emens LA;
|
||
IMpassion130 Trial Investigators</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2018 Nov 29;379(22):2108-2121.
|
||
Epub 2018 Oct 20
|
||
doi: 10.1056/NEJMoa1809615.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30345906" target="_blank">30345906</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Locally%20Advanced%20Unresectable%20Breast%20Carcinoma%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (112)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39013199">Expert consensus: Profiling and management of advanced or metastatic epithelial ovarian cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pierre ME,
|
||
Manneh R,
|
||
Hernández A,
|
||
Rodríguez J,
|
||
Fletcher AV,
|
||
Ramírez HM,
|
||
Niño OM,
|
||
Gómez DA,
|
||
Sanabria D,
|
||
Contreras F,
|
||
Pieschacón JR,
|
||
Calderón PH</span><br />
|
||
<span class="medgenPMjournal">Rev Colomb Obstet Ginecol</span>
|
||
2024 Jun 14;75(1)
|
||
doi: 10.18597/rcog.4094.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39013199" target="_blank">39013199</a><a href="/pmc/articles/PMC11210286" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38755096">IMpassion132 double-blind randomised phase III trial of chemotherapy with or without atezolizumab for early relapsing unresectable locally advanced or metastatic triple-negative breast cancer.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Dent R,
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André F,
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Gonçalves A,
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Martin M,
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Im SA,
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Park YH,
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Bianchini G,
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Li H,
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Kirchmayer Machackova Z,
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Epub 2024 May 15
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doi: 10.1016/j.annonc.2024.04.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38755096" target="_blank">38755096</a></div>
|
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||
<div class="nl"><a target="_blank" href="/pubmed/33015734">Pembrolizumab and atezolizumab in triple-negative breast cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kwapisz D</span><br />
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2021 Mar;70(3):607-617.
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Epub 2020 Oct 5
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<span class="bold">PMID: </span><a href="/pubmed/33015734" target="_blank">33015734</a><a href="/pmc/articles/PMC10992894" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31786121">Atezolizumab plus nab-paclitaxel as first-line treatment for unresectable, locally advanced or metastatic triple-negative breast cancer (IMpassion130): updated efficacy results from a randomised, double-blind, placebo-controlled, phase 3 trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schmid P,
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Rugo HS,
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Adams S,
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Schneeweiss A,
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Barrios CH,
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Iwata H,
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Diéras V,
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Henschel V,
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Molinero L,
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Chui SY,
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Maiya V,
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Husain A,
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Winer EP,
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Loi S,
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Emens LA;
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<span class="medgenPMjournal">Lancet Oncol</span>
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2020 Jan;21(1):44-59.
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Epub 2019 Nov 27
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doi: 10.1016/S1470-2045(19)30689-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31786121" target="_blank">31786121</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28526536">Trastuzumab emtansine versus capecitabine plus lapatinib in patients with previously treated HER2-positive advanced breast cancer (EMILIA): a descriptive analysis of final overall survival results from a randomised, open-label, phase 3 trial.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Diéras V,
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Miles D,
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Verma S,
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Pegram M,
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Welslau M,
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Baselga J,
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Krop IE,
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<span class="medgenPMjournal">Lancet Oncol</span>
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2017 Jun;18(6):732-742.
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Epub 2017 May 16
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doi: 10.1016/S1470-2045(17)30312-1.
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<span class="bold">PMID: </span><a href="/pubmed/28526536" target="_blank">28526536</a><a href="/pmc/articles/PMC5531181" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Locally%20Advanced%20Unresectable%20Breast%20Carcinoma%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (54)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/39013199">Expert consensus: Profiling and management of advanced or metastatic epithelial ovarian cancer.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Pierre ME,
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Manneh R,
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Hernández A,
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Rodríguez J,
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Fletcher AV,
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Ramírez HM,
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Niño OM,
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Gómez DA,
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Sanabria D,
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Contreras F,
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Pieschacón JR,
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Calderón PH</span><br />
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<span class="medgenPMjournal">Rev Colomb Obstet Ginecol</span>
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2024 Jun 14;75(1)
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doi: 10.18597/rcog.4094.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39013199" target="_blank">39013199</a><a href="/pmc/articles/PMC11210286" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38577882">Clinical efficacy of tumor organoid-guided cancer therapy for locally advanced unresectable or metastatic breast cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lin YY,
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Gao HF,
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Li H,
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Hu Q,
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Du BL,
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Li S,
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Xu FP,
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Cheng MY,
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Zou JC,
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Zheng XX,
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Zhu T,
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Wang K</span><br />
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<span class="medgenPMjournal">Int J Cancer</span>
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2024 Aug 15;155(4):697-709.
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Epub 2024 Apr 5
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||
doi: 10.1002/ijc.34945.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38577882" target="_blank">38577882</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34272041">First-line atezolizumab plus nab-paclitaxel for unresectable, locally advanced, or metastatic triple-negative breast cancer: IMpassion130 final overall survival analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Emens LA,
|
||
Adams S,
|
||
Barrios CH,
|
||
Diéras V,
|
||
Iwata H,
|
||
Loi S,
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||
Rugo HS,
|
||
Schneeweiss A,
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Winer EP,
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Patel S,
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Henschel V,
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Swat A,
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Kaul M,
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Molinero L,
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Patel S,
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Chui SY,
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Schmid P</span><br />
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<span class="medgenPMjournal">Ann Oncol</span>
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||
2021 Aug;32(8):983-993.
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||
Epub 2021 Jul 1
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||
doi: 10.1016/j.annonc.2021.05.355.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34272041" target="_blank">34272041</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33523233">Atezolizumab and nab-Paclitaxel in Advanced Triple-Negative Breast Cancer: Biomarker Evaluation of the IMpassion130 Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Emens LA,
|
||
Molinero L,
|
||
Loi S,
|
||
Rugo HS,
|
||
Schneeweiss A,
|
||
Diéras V,
|
||
Iwata H,
|
||
Barrios CH,
|
||
Nechaeva M,
|
||
Nguyen-Duc A,
|
||
Chui SY,
|
||
Husain A,
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||
Winer EP,
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Adams S,
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||
Schmid P</span><br />
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<span class="medgenPMjournal">J Natl Cancer Inst</span>
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||
2021 Aug 2;113(8):1005-1016.
|
||
doi: 10.1093/jnci/djab004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33523233" target="_blank">33523233</a><a href="/pmc/articles/PMC8328980" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32353342">Abemaciclib plus trastuzumab with or without fulvestrant versus trastuzumab plus standard-of-care chemotherapy in women with hormone receptor-positive, HER2-positive advanced breast cancer (monarcHER): a randomised, open-label, phase 2 trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tolaney SM,
|
||
Wardley AM,
|
||
Zambelli S,
|
||
Hilton JF,
|
||
Troso-Sandoval TA,
|
||
Ricci F,
|
||
Im SA,
|
||
Kim SB,
|
||
Johnston SR,
|
||
Chan A,
|
||
Goel S,
|
||
Catron K,
|
||
Chapman SC,
|
||
Price GL,
|
||
Yang Z,
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||
Gainford MC,
|
||
André F</span><br />
|
||
<span class="medgenPMjournal">Lancet Oncol</span>
|
||
2020 Jun;21(6):763-775.
|
||
Epub 2020 Apr 27
|
||
doi: 10.1016/S1470-2045(20)30112-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32353342" target="_blank">32353342</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Locally%20Advanced%20Unresectable%20Breast%20Carcinoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (38)</a></div></div>
|
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|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/38808848">Trastuzumab-emtansine versus other anti-HER2 regimens in early or unresectable or metastatic HER-2 positive breast cancer: systematic review and network meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ciapponi A,
|
||
Bardach A,
|
||
Colaci C,
|
||
Rodríguez Cairoli F,
|
||
Argento F,
|
||
Korbenfeld E,
|
||
García Martí S</span><br />
|
||
<span class="medgenPMjournal">Rev Peru Med Exp Salud Publica</span>
|
||
2024 May 27;41(1):7-18.
|
||
doi: 10.17843/rpmesp.2024.411.13351.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38808848" target="_blank">38808848</a><a href="/pmc/articles/PMC11152244" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38597713">Pembrolizumab plus chemotherapy for first-line treatment of advanced triple-negative breast cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Haiderali A,
|
||
Huang M,
|
||
Pan W,
|
||
Akers KG,
|
||
Maciel D,
|
||
Frederickson AM</span><br />
|
||
<span class="medgenPMjournal">Future Oncol</span>
|
||
2024;20(22):1587-1600.
|
||
Epub 2024 Apr 10
|
||
doi: 10.2217/fon-2023-0301.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38597713" target="_blank">38597713</a><a href="/pmc/articles/PMC11457619" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32100144">Evaluating the clinical effectiveness and safety of various HER2-targeted regimens after prior taxane/trastuzumab in patients with previously treated, unresectable, or metastatic HER2-positive breast cancer: a systematic review and network meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Paracha N,
|
||
Reyes A,
|
||
Diéras V,
|
||
Krop I,
|
||
Pivot X,
|
||
Urruticoechea A</span><br />
|
||
<span class="medgenPMjournal">Breast Cancer Res Treat</span>
|
||
2020 Apr;180(3):597-609.
|
||
Epub 2020 Feb 25
|
||
doi: 10.1007/s10549-020-05577-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32100144" target="_blank">32100144</a><a href="/pmc/articles/PMC7103014" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Locally%20Advanced%20Unresectable%20Breast%20Carcinoma%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3)</a></div></div>
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|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(locally%20advanced%20unresectable%20breast%20carcinoma)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Locally%20Advanced%20Unresectable%20Breast%20Carcinoma%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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|
||
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<div class="row">
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<div class="col-lg-12 centered-lg">
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||
<li>
|
||
<a class="text-white" href="//www.nlm.nih.gov/">NLM</a>
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||
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<li>
|
||
<a class="text-white" href="https://www.nih.gov/">NIH</a>
|
||
</li>
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||
<li>
|
||
<a class="text-white" href="https://www.hhs.gov/">HHS</a>
|
||
</li>
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<li>
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<a class="text-white" href="https://www.usa.gov/">USA.gov</a>
|
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