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<!--
|
||
UID=1697431
|
||
ConceptID=C5206129
|
||
-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Metastatic BRCA-Associated Breast Carcinoma</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1697431</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5206129</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>BRCA-Mutated Metastatic Breast Carcinoma; Metastatic BRCA-Mutated Breast Carcinoma</td></tr>
|
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</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">BRCA-associated breast carcinoma that has spread to another anatomic site. [from <a title="NCI Thesaurus" href="http://ncit.nci.nih.gov" class="defSource" target="_blank">NCI</a>]</div>
|
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Metastatic BRCA-Associated Breast Carcinoma</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/10294" ref="tree=MeSH" title="MedGen record for Neoplasm">Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/14297" ref="tree=MeSH" title="MedGen record for Malignant neoplastic disease">Malignant neoplastic disease</a></span><ul><li><span class="TLline"><a href="/medgen/232504" ref="tree=MeSH" title="MedGen record for Hereditary cancer">Hereditary cancer</a></span><ul><li><span class="TLline"><a href="/medgen/1710602" ref="tree=MeSH" title="MedGen record for BRCA-Associated Malignant Neoplasm">BRCA-Associated Malignant Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/1710970" ref="tree=MeSH" title="MedGen record for BRCA-Associated Breast Carcinoma">BRCA-Associated Breast Carcinoma</a></span><ul><li><span class="matched_ds">Metastatic BRCA-Associated Breast Carcinoma</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
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||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32633033">Medical Management of newly diagnosed breast cancer in a BRCA1/2 mutation carrier.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Desai NV,
|
||
Tung NM</span><br />
|
||
<span class="medgenPMjournal">Breast J</span>
|
||
2020 Aug;26(8):1506-1512.
|
||
Epub 2020 Jul 6
|
||
doi: 10.1111/tbj.13972.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32633033" target="_blank">32633033</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30067621">Development of poly(ADP-ribose) polymerase inhibitors in the treatment of BRCA-mutated breast cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sulai NH,
|
||
Tan AR</span><br />
|
||
<span class="medgenPMjournal">Clin Adv Hematol Oncol</span>
|
||
2018 Jul;16(7):491-501.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30067621" target="_blank">30067621</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21934105">An emerging entity: pancreatic adenocarcinoma associated with a known BRCA mutation: clinical descriptors, treatment implications, and future directions.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lowery MA,
|
||
Kelsen DP,
|
||
Stadler ZK,
|
||
Yu KH,
|
||
Janjigian YY,
|
||
Ludwig E,
|
||
D'Adamo DR,
|
||
Salo-Mullen E,
|
||
Robson ME,
|
||
Allen PJ,
|
||
Kurtz RC,
|
||
O'Reilly EM</span><br />
|
||
<span class="medgenPMjournal">Oncologist</span>
|
||
2011;16(10):1397-402.
|
||
Epub 2011 Sep 20
|
||
doi: 10.1634/theoncologist.2011-0185.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21934105" target="_blank">21934105</a><a href="/pmc/articles/PMC3228075" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(metastatic%20brca-associated%20breast%20carcinoma)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (3)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37369040">Contralateral breast cancer risk in patients with breast cancer and a germline-BRCA1/2 pathogenic variant undergoing radiation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">van Barele M,
|
||
Akdeniz D,
|
||
Heemskerk-Gerritsen BAM;
|
||
Genepso,
|
||
Andrieu N,
|
||
Noguès C;
|
||
HEBON,
|
||
van Asperen CJ,
|
||
Wevers M,
|
||
Ausems MGEM,
|
||
de Bock GH,
|
||
Dommering CJ,
|
||
Gómez-García EB,
|
||
van Leeuwen FE,
|
||
Mooij TM;
|
||
EMBRACE,
|
||
Easton DF,
|
||
Antoniou AC,
|
||
Evans DG,
|
||
Izatt L,
|
||
Tischkowitz M,
|
||
Frost D,
|
||
Brewer C,
|
||
Olah E,
|
||
Simard J,
|
||
Singer CF,
|
||
Thomassen M,
|
||
Kast K,
|
||
Rhiem K,
|
||
Engel C,
|
||
de la Hoya M,
|
||
Foretová L,
|
||
Jakubowska A,
|
||
Jager A,
|
||
Sattler MGA,
|
||
Schmidt MK,
|
||
Hooning MJ</span><br />
|
||
<span class="medgenPMjournal">J Natl Cancer Inst</span>
|
||
2023 Nov 8;115(11):1318-1328.
|
||
doi: 10.1093/jnci/djad116.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37369040" target="_blank">37369040</a><a href="/pmc/articles/PMC10637040" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37021836">Molecular basis and therapeutic targets in prostate cancer: A comprehensive review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Militaru FC,
|
||
Militaru V,
|
||
Crisan N,
|
||
Bocsan IC,
|
||
Udrea AA,
|
||
Catana A,
|
||
Kutasi E,
|
||
Militaru MS</span><br />
|
||
<span class="medgenPMjournal">Biomol Biomed</span>
|
||
2023 Sep 4;23(5):760-771.
|
||
doi: 10.17305/bb.2023.8782.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37021836" target="_blank">37021836</a><a href="/pmc/articles/PMC10494850" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36690978">Risk of seizures in a population of women with BRCA-positive metastatic breast cancer from an electronic health record database in the United States.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Liede A,
|
||
Sebby W,
|
||
Miriyala AKR,
|
||
Potluri R,
|
||
Mazumder D,
|
||
Ghosh A,
|
||
Papademetriou E,
|
||
Kilpatrick R,
|
||
Tyczynski JE</span><br />
|
||
<span class="medgenPMjournal">BMC Cancer</span>
|
||
2023 Jan 24;23(1):78.
|
||
doi: 10.1186/s12885-023-10554-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36690978" target="_blank">36690978</a><a href="/pmc/articles/PMC9872301" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32633033">Medical Management of newly diagnosed breast cancer in a BRCA1/2 mutation carrier.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Desai NV,
|
||
Tung NM</span><br />
|
||
<span class="medgenPMjournal">Breast J</span>
|
||
2020 Aug;26(8):1506-1512.
|
||
Epub 2020 Jul 6
|
||
doi: 10.1111/tbj.13972.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32633033" target="_blank">32633033</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32084523">Radiation-Associated Secondary Malignancies in BRCA Mutation Carriers Treated for Breast Cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schlosser S,
|
||
Rabinovitch R,
|
||
Shatz Z,
|
||
Galper S,
|
||
Shahadi-Dromi I,
|
||
Finkel S,
|
||
Jacobson G,
|
||
Rasco A,
|
||
Friedman E,
|
||
Laitman Y,
|
||
Evron E,
|
||
Bernstein R,
|
||
Weiss I,
|
||
Sklair-Levy M,
|
||
Ben-David MA</span><br />
|
||
<span class="medgenPMjournal">Int J Radiat Oncol Biol Phys</span>
|
||
2020 Jun 1;107(2):353-359.
|
||
Epub 2020 Feb 19
|
||
doi: 10.1016/j.ijrobp.2020.02.020.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32084523" target="_blank">32084523</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Metastatic%20BRCA-Associated%20Breast%20Carcinoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (15)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37369040">Contralateral breast cancer risk in patients with breast cancer and a germline-BRCA1/2 pathogenic variant undergoing radiation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">van Barele M,
|
||
Akdeniz D,
|
||
Heemskerk-Gerritsen BAM;
|
||
Genepso,
|
||
Andrieu N,
|
||
Noguès C;
|
||
HEBON,
|
||
van Asperen CJ,
|
||
Wevers M,
|
||
Ausems MGEM,
|
||
de Bock GH,
|
||
Dommering CJ,
|
||
Gómez-García EB,
|
||
van Leeuwen FE,
|
||
Mooij TM;
|
||
EMBRACE,
|
||
Easton DF,
|
||
Antoniou AC,
|
||
Evans DG,
|
||
Izatt L,
|
||
Tischkowitz M,
|
||
Frost D,
|
||
Brewer C,
|
||
Olah E,
|
||
Simard J,
|
||
Singer CF,
|
||
Thomassen M,
|
||
Kast K,
|
||
Rhiem K,
|
||
Engel C,
|
||
de la Hoya M,
|
||
Foretová L,
|
||
Jakubowska A,
|
||
Jager A,
|
||
Sattler MGA,
|
||
Schmidt MK,
|
||
Hooning MJ</span><br />
|
||
<span class="medgenPMjournal">J Natl Cancer Inst</span>
|
||
2023 Nov 8;115(11):1318-1328.
|
||
doi: 10.1093/jnci/djad116.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37369040" target="_blank">37369040</a><a href="/pmc/articles/PMC10637040" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37021836">Molecular basis and therapeutic targets in prostate cancer: A comprehensive review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Militaru FC,
|
||
Militaru V,
|
||
Crisan N,
|
||
Bocsan IC,
|
||
Udrea AA,
|
||
Catana A,
|
||
Kutasi E,
|
||
Militaru MS</span><br />
|
||
<span class="medgenPMjournal">Biomol Biomed</span>
|
||
2023 Sep 4;23(5):760-771.
|
||
doi: 10.17305/bb.2023.8782.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37021836" target="_blank">37021836</a><a href="/pmc/articles/PMC10494850" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33617901">Patient-derived xenograft models of BRCA-associated pancreatic cancers.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Golan T,
|
||
Atias D,
|
||
Stossel C,
|
||
Raitses-Gurevich M</span><br />
|
||
<span class="medgenPMjournal">Adv Drug Deliv Rev</span>
|
||
2021 Apr;171:257-265.
|
||
Epub 2021 Feb 20
|
||
doi: 10.1016/j.addr.2021.02.010.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33617901" target="_blank">33617901</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32633033">Medical Management of newly diagnosed breast cancer in a BRCA1/2 mutation carrier.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Desai NV,
|
||
Tung NM</span><br />
|
||
<span class="medgenPMjournal">Breast J</span>
|
||
2020 Aug;26(8):1506-1512.
|
||
Epub 2020 Jul 6
|
||
doi: 10.1111/tbj.13972.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32633033" target="_blank">32633033</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30231328">Innovative Strategies: Targeting Subtypes in Metastatic Breast Cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pegram MD,
|
||
Zong Y,
|
||
Yam C,
|
||
Goetz MP,
|
||
Moulder SL</span><br />
|
||
<span class="medgenPMjournal">Am Soc Clin Oncol Educ Book</span>
|
||
2018 May 23;38:65-77.
|
||
doi: 10.1200/EDBK_200715.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30231328" target="_blank">30231328</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Metastatic%20BRCA-Associated%20Breast%20Carcinoma%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (15)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37021836">Molecular basis and therapeutic targets in prostate cancer: A comprehensive review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Militaru FC,
|
||
Militaru V,
|
||
Crisan N,
|
||
Bocsan IC,
|
||
Udrea AA,
|
||
Catana A,
|
||
Kutasi E,
|
||
Militaru MS</span><br />
|
||
<span class="medgenPMjournal">Biomol Biomed</span>
|
||
2023 Sep 4;23(5):760-771.
|
||
doi: 10.17305/bb.2023.8782.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37021836" target="_blank">37021836</a><a href="/pmc/articles/PMC10494850" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32633033">Medical Management of newly diagnosed breast cancer in a BRCA1/2 mutation carrier.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Desai NV,
|
||
Tung NM</span><br />
|
||
<span class="medgenPMjournal">Breast J</span>
|
||
2020 Aug;26(8):1506-1512.
|
||
Epub 2020 Jul 6
|
||
doi: 10.1111/tbj.13972.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32633033" target="_blank">32633033</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32084523">Radiation-Associated Secondary Malignancies in BRCA Mutation Carriers Treated for Breast Cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schlosser S,
|
||
Rabinovitch R,
|
||
Shatz Z,
|
||
Galper S,
|
||
Shahadi-Dromi I,
|
||
Finkel S,
|
||
Jacobson G,
|
||
Rasco A,
|
||
Friedman E,
|
||
Laitman Y,
|
||
Evron E,
|
||
Bernstein R,
|
||
Weiss I,
|
||
Sklair-Levy M,
|
||
Ben-David MA</span><br />
|
||
<span class="medgenPMjournal">Int J Radiat Oncol Biol Phys</span>
|
||
2020 Jun 1;107(2):353-359.
|
||
Epub 2020 Feb 19
|
||
doi: 10.1016/j.ijrobp.2020.02.020.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32084523" target="_blank">32084523</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31625002">PARP Inhibition in Cancer: An Update on Clinical Development.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sachdev E,
|
||
Tabatabai R,
|
||
Roy V,
|
||
Rimel BJ,
|
||
Mita MM</span><br />
|
||
<span class="medgenPMjournal">Target Oncol</span>
|
||
2019 Dec;14(6):657-679.
|
||
doi: 10.1007/s11523-019-00680-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31625002" target="_blank">31625002</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30231328">Innovative Strategies: Targeting Subtypes in Metastatic Breast Cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pegram MD,
|
||
Zong Y,
|
||
Yam C,
|
||
Goetz MP,
|
||
Moulder SL</span><br />
|
||
<span class="medgenPMjournal">Am Soc Clin Oncol Educ Book</span>
|
||
2018 May 23;38:65-77.
|
||
doi: 10.1200/EDBK_200715.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30231328" target="_blank">30231328</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Metastatic%20BRCA-Associated%20Breast%20Carcinoma%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (16)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37021836">Molecular basis and therapeutic targets in prostate cancer: A comprehensive review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Militaru FC,
|
||
Militaru V,
|
||
Crisan N,
|
||
Bocsan IC,
|
||
Udrea AA,
|
||
Catana A,
|
||
Kutasi E,
|
||
Militaru MS</span><br />
|
||
<span class="medgenPMjournal">Biomol Biomed</span>
|
||
2023 Sep 4;23(5):760-771.
|
||
doi: 10.17305/bb.2023.8782.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37021836" target="_blank">37021836</a><a href="/pmc/articles/PMC10494850" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36033386">Machine Learning-Devised Immune-Related lncRNA Signature Panel Predicts the Prognosis and Immune Landscape in Breast Cancer Novel IRLP Signature in BRCA.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhu JY,
|
||
Lyu AQ,
|
||
Wang ZT,
|
||
Chan WY,
|
||
Qin T,
|
||
Miu KK,
|
||
Yao HR</span><br />
|
||
<span class="medgenPMjournal">J Immunol Res</span>
|
||
2022;2022:3704798.
|
||
Epub 2022 Aug 18
|
||
doi: 10.1155/2022/3704798.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36033386" target="_blank">36033386</a><a href="/pmc/articles/PMC9410861" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33399070">Germinal BRCA1-2 pathogenic variants (gBRCA1-2pv) and pancreatic cancer: epidemiology of an Italian patient cohort.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Peretti U,
|
||
Cavaliere A,
|
||
Niger M,
|
||
Tortora G,
|
||
Di Marco MC,
|
||
Rodriquenz MG,
|
||
Centonze F,
|
||
Rapposelli IG,
|
||
Giordano G,
|
||
De Vita F,
|
||
Stuppia L,
|
||
Avallone A,
|
||
Ratti M,
|
||
Paratore C,
|
||
Forti LG,
|
||
Orsi G,
|
||
Valente MM,
|
||
Gaule M,
|
||
Macchini M,
|
||
Carrera P,
|
||
Calzavara S,
|
||
Simbolo M,
|
||
Melisi D,
|
||
De Braud F,
|
||
Salvatore L,
|
||
De Lorenzo S,
|
||
Chiarazzo C,
|
||
Falconi M,
|
||
Cascinu S,
|
||
Milella M,
|
||
Reni M</span><br />
|
||
<span class="medgenPMjournal">ESMO Open</span>
|
||
2021 Feb;6(1):100032.
|
||
Epub 2021 Jan 4
|
||
doi: 10.1016/j.esmoop.2020.100032.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33399070" target="_blank">33399070</a><a href="/pmc/articles/PMC7807989" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31625002">PARP Inhibition in Cancer: An Update on Clinical Development.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sachdev E,
|
||
Tabatabai R,
|
||
Roy V,
|
||
Rimel BJ,
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||
Mita MM</span><br />
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<span class="medgenPMjournal">Target Oncol</span>
|
||
2019 Dec;14(6):657-679.
|
||
doi: 10.1007/s11523-019-00680-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31625002" target="_blank">31625002</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17584985">Studies of osteotropism on both sides of the breast cancer-bone interaction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Moreau J,
|
||
Anderson KM,
|
||
Mauney JR,
|
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Kaplan D,
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Rosenblatt M</span><br />
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<span class="medgenPMjournal">Ann N Y Acad Sci</span>
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2007 Nov;1117:328-44.
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Epub 2007 Jun 21
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||
doi: 10.1196/annals.1402.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17584985" target="_blank">17584985</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Metastatic%20BRCA-Associated%20Breast%20Carcinoma%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (9)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37369040">Contralateral breast cancer risk in patients with breast cancer and a germline-BRCA1/2 pathogenic variant undergoing radiation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">van Barele M,
|
||
Akdeniz D,
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||
Heemskerk-Gerritsen BAM;
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||
Genepso,
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Andrieu N,
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Noguès C;
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||
HEBON,
|
||
van Asperen CJ,
|
||
Wevers M,
|
||
Ausems MGEM,
|
||
de Bock GH,
|
||
Dommering CJ,
|
||
Gómez-García EB,
|
||
van Leeuwen FE,
|
||
Mooij TM;
|
||
EMBRACE,
|
||
Easton DF,
|
||
Antoniou AC,
|
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Evans DG,
|
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Izatt L,
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Tischkowitz M,
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Frost D,
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Brewer C,
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Olah E,
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Simard J,
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Singer CF,
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Thomassen M,
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Kast K,
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Rhiem K,
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Engel C,
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de la Hoya M,
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Foretová L,
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Jakubowska A,
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Jager A,
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Sattler MGA,
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Schmidt MK,
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Hooning MJ</span><br />
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<span class="medgenPMjournal">J Natl Cancer Inst</span>
|
||
2023 Nov 8;115(11):1318-1328.
|
||
doi: 10.1093/jnci/djad116.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37369040" target="_blank">37369040</a><a href="/pmc/articles/PMC10637040" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36033386">Machine Learning-Devised Immune-Related lncRNA Signature Panel Predicts the Prognosis and Immune Landscape in Breast Cancer Novel IRLP Signature in BRCA.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhu JY,
|
||
Lyu AQ,
|
||
Wang ZT,
|
||
Chan WY,
|
||
Qin T,
|
||
Miu KK,
|
||
Yao HR</span><br />
|
||
<span class="medgenPMjournal">J Immunol Res</span>
|
||
2022;2022:3704798.
|
||
Epub 2022 Aug 18
|
||
doi: 10.1155/2022/3704798.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36033386" target="_blank">36033386</a><a href="/pmc/articles/PMC9410861" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34417675">Phase II trial of veliparib and temozolomide in metastatic breast cancer patients with and without BRCA1/2 mutations.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Xu J,
|
||
Keenan TE,
|
||
Overmoyer B,
|
||
Tung NM,
|
||
Gelman RS,
|
||
Habin K,
|
||
Garber JE,
|
||
Ellisen LW,
|
||
Winer EP,
|
||
Goss PE,
|
||
Yeap BY,
|
||
Chabner BA,
|
||
Isakoff SJ</span><br />
|
||
<span class="medgenPMjournal">Breast Cancer Res Treat</span>
|
||
2021 Oct;189(3):641-651.
|
||
Epub 2021 Aug 20
|
||
doi: 10.1007/s10549-021-06292-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34417675" target="_blank">34417675</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33399070">Germinal BRCA1-2 pathogenic variants (gBRCA1-2pv) and pancreatic cancer: epidemiology of an Italian patient cohort.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Peretti U,
|
||
Cavaliere A,
|
||
Niger M,
|
||
Tortora G,
|
||
Di Marco MC,
|
||
Rodriquenz MG,
|
||
Centonze F,
|
||
Rapposelli IG,
|
||
Giordano G,
|
||
De Vita F,
|
||
Stuppia L,
|
||
Avallone A,
|
||
Ratti M,
|
||
Paratore C,
|
||
Forti LG,
|
||
Orsi G,
|
||
Valente MM,
|
||
Gaule M,
|
||
Macchini M,
|
||
Carrera P,
|
||
Calzavara S,
|
||
Simbolo M,
|
||
Melisi D,
|
||
De Braud F,
|
||
Salvatore L,
|
||
De Lorenzo S,
|
||
Chiarazzo C,
|
||
Falconi M,
|
||
Cascinu S,
|
||
Milella M,
|
||
Reni M</span><br />
|
||
<span class="medgenPMjournal">ESMO Open</span>
|
||
2021 Feb;6(1):100032.
|
||
Epub 2021 Jan 4
|
||
doi: 10.1016/j.esmoop.2020.100032.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33399070" target="_blank">33399070</a><a href="/pmc/articles/PMC7807989" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28356425">Efficacy of the PARP Inhibitor Veliparib with Carboplatin or as a Single Agent in Patients with Germline BRCA1- or BRCA2-Associated Metastatic Breast Cancer: California Cancer Consortium Trial NCT01149083.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Somlo G,
|
||
Frankel PH,
|
||
Arun BK,
|
||
Ma CX,
|
||
Garcia AA,
|
||
Cigler T,
|
||
Cream LV,
|
||
Harvey HA,
|
||
Sparano JA,
|
||
Nanda R,
|
||
Chew HK,
|
||
Moynihan TJ,
|
||
Vahdat LT,
|
||
Goetz MP,
|
||
Beumer JH,
|
||
Hurria A,
|
||
Mortimer J,
|
||
Piekarz R,
|
||
Sand S,
|
||
Herzog J,
|
||
Van Tongeren LR,
|
||
Ferry-Galow KV,
|
||
Chen AP,
|
||
Ruel C,
|
||
Newman EM,
|
||
Gandara DR,
|
||
Weitzel JN</span><br />
|
||
<span class="medgenPMjournal">Clin Cancer Res</span>
|
||
2017 Aug 1;23(15):4066-4076.
|
||
Epub 2017 Mar 29
|
||
doi: 10.1158/1078-0432.CCR-16-2714.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28356425" target="_blank">28356425</a><a href="/pmc/articles/PMC5540749" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Metastatic%20BRCA-Associated%20Breast%20Carcinoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (9)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
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|
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|
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<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(metastatic%20brca-associated%20breast%20carcinoma)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Metastatic%20BRCA-Associated%20Breast%20Carcinoma%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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