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<!--
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UID=1690106
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ConceptID=C5139211
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Increased circulating creatine kinase MB isoform</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1690106</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5139211</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
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<td>Increased circulating CK MB isoform</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0032232">HP:0032232</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">An increased concentration of the MB isoform of creatine kinase in the blood circulation. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Increased circulating creatine kinase MB isoform</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/867398" ref="tree=MeSH" title="MedGen record for Abnormality of metabolism/homeostasis">Abnormality of metabolism/homeostasis</a></span><ul><li><span class="TLline"><a href="/medgen/1701080" ref="tree=MeSH" title="MedGen record for Abnormal circulating metabolite concentration">Abnormal circulating metabolite concentration</a></span><ul><li><span class="TLline"><a href="/medgen/892289" ref="tree=MeSH" title="MedGen record for Abnormal circulating protein concentration">Abnormal circulating protein concentration</a></span><ul><li><span class="TLline"><a href="/medgen/869169" ref="tree=MeSH" title="MedGen record for Abnormal circulating enzyme concentration">Abnormal circulating enzyme concentration</a></span><ul><li><span class="TLline"><a href="/medgen/868058" ref="tree=MeSH" title="MedGen record for Abnormal circulating creatine kinase concentration">Abnormal circulating creatine kinase concentration</a></span><ul><li><span class="matched_ds">Increased circulating creatine kinase MB isoform</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_5340"><div><strong>Glycogen storage disease, type II</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>5340</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0017921</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Pompe disease is classified by age of onset, organ involvement, severity, and rate of progression. Infantile-onset Pompe disease (IOPD; individuals with onset before age 12 months with cardiomyopathy) may be apparent in utero but more typically onset is at the median age of four months with hypotonia, generalized muscle weakness, feeding difficulties, failure to thrive, respiratory distress, and hypertrophic cardiomyopathy. Without treatment by enzyme replacement therapy (ERT), IOPD commonly results in death by age two years from progressive left ventricular outflow obstruction and respiratory insufficiency. Late-onset Pompe disease (LOPD; including: (a) individuals with onset before age 12 months without cardiomyopathy; and (b) all individuals with onset after age 12 months) is characterized by proximal muscle weakness and respiratory insufficiency; clinically significant cardiac involvement is uncommon.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/5340">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_335320"><div><strong>Uruguay Faciocardiomusculoskeletal syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>335320</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1846010</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Uruguay faciocardiomusculoskeletal syndrome (FCMSU) is an X-linked disorder in which affected males have a distinctive facial appearance, muscular hypertrophy, and cardiac ventricular hypertrophy leading to premature death. Additional features include large, broad, and deformed hands and feet, congenital hip dislocation, and scoliosis (summary by Xue et al., 2016).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/335320">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_347543"><div><strong>Arrhythmogenic right ventricular dysplasia 10</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>347543</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1857777</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">ARVC may not cause any symptoms in its early stages. However, affected individuals may still be at risk of sudden death, especially during strenuous exercise. When symptoms occur, they most commonly include a sensation of fluttering or pounding in the chest (palpitations), light-headedness, and fainting (syncope). Over time, ARVC can also cause shortness of breath and abnormal swelling in the legs or abdomen. If the myocardium becomes severely damaged in the later stages of the disease, it can lead to heart failure.\n\nArrhythmogenic right ventricular cardiomyopathy (ARVC) is a form of heart disease that usually appears in adulthood. ARVC is a disorder of the myocardium, which is the muscular wall of the heart. This condition causes part of the myocardium to break down over time, increasing the risk of an abnormal heartbeat (arrhythmia) and sudden death.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/347543">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_777148"><div><strong>Dilated cardiomyopathy 3B</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>777148</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3668940</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The dystrophinopathies cover a spectrum of X-linked muscle disease ranging from mild to severe that includes Duchenne muscular dystrophy, Becker muscular dystrophy, and DMD-associated dilated cardiomyopathy (DCM). The mild end of the spectrum includes the phenotypes of asymptomatic increase in serum concentration of creatine phosphokinase (CK) and muscle cramps with myoglobinuria. The severe end of the spectrum includes progressive muscle diseases that are classified as Duchenne/Becker muscular dystrophy when skeletal muscle is primarily affected and as DMD-associated DCM when the heart is primarily affected. Duchenne muscular dystrophy (DMD) usually presents in early childhood with delayed motor milestones including delays in walking independently and standing up from a supine position. Proximal weakness causes a waddling gait and difficulty climbing stairs, running, jumping, and standing up from a squatting position. DMD is rapidly progressive, with affected children being wheelchair dependent by age 12 years. Cardiomyopathy occurs in almost all individuals with DMD after age 18 years. Few survive beyond the third decade, with respiratory complications and progressive cardiomyopathy being common causes of death. Becker muscular dystrophy (BMD) is characterized by later-onset skeletal muscle weakness. With improved diagnostic techniques, it has been recognized that the mild end of the spectrum includes men with onset of symptoms after age 30 years who remain ambulatory even into their 60s. Despite the milder skeletal muscle involvement, heart failure from DCM is a common cause of morbidity and the most common cause of death in BMD. Mean age of death is in the mid-40s. DMD-associated DCM is characterized by left ventricular dilatation and congestive heart failure. Females heterozygous for a DMD pathogenic variant are at increased risk for DCM.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/777148">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1621949"><div><strong>Psychomotor regression-oculomotor apraxia-movement disorder-nephropathy syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1621949</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4539828</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Birk-Landau-Perez syndrome (BILAPES) is an autosomal recessive syndromic developmental disorder characterized by global developmental delay apparent from infancy or early childhood. Some patients have developmental regression with loss of speech and motor skills, whereas other patients never achieve these milestones. More variable features may include hypotonia, poor overall growth, ataxia, dystonia, abnormal eye movements, and renal insufficiency (Perez et al., 2017; Kleyner et al., 2022).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1621949">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_347543" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Arrhythmogenic right ventricular dysplasia 10</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_777148" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dilated cardiomyopathy 3B</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_5340" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Glycogen storage disease, type II</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1621949" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Psychomotor regression-oculomotor apraxia-movement disorder-nephropathy syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_335320" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Uruguay Faciocardiomusculoskeletal syndrome</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37037296">The liver and blood cells are responsible for creatine kinase clearance in blood Circulation: A retrospective study among different human diseases.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pan N,
|
||
Wu Y,
|
||
Yang B,
|
||
Zhang M,
|
||
He Y,
|
||
Wang Z,
|
||
Tan L,
|
||
Zhang L</span><br />
|
||
<span class="medgenPMjournal">Clin Chim Acta</span>
|
||
2023 Apr 1;544:117335.
|
||
Epub 2023 Apr 8
|
||
doi: 10.1016/j.cca.2023.117335.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37037296" target="_blank">37037296</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16008158">Prognostic significance of creatine kinase release after percutaneous coronary intervention.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cavallini C,
|
||
Rugolotto M,
|
||
Savonitto S</span><br />
|
||
<span class="medgenPMjournal">Ital Heart J</span>
|
||
2005 Jun;6(6):522-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16008158" target="_blank">16008158</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15249498">Anti-Xa activity relates to survival and efficacy in unselected acute coronary syndrome patients treated with enoxaparin.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Montalescot G,
|
||
Collet JP,
|
||
Tanguy ML,
|
||
Ankri A,
|
||
Payot L,
|
||
Dumaine R,
|
||
Choussat R,
|
||
Beygui F,
|
||
Gallois V,
|
||
Thomas D</span><br />
|
||
<span class="medgenPMjournal">Circulation</span>
|
||
2004 Jul 27;110(4):392-8.
|
||
Epub 2004 Jul 12
|
||
doi: 10.1161/01.CIR.0000136830.65073.C7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15249498" target="_blank">15249498</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8873665">Creatine kinase system in failing and nonfailing human myocardium.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nascimben L,
|
||
Ingwall JS,
|
||
Pauletto P,
|
||
Friedrich J,
|
||
Gwathmey JK,
|
||
Saks V,
|
||
Pessina AC,
|
||
Allen PD</span><br />
|
||
<span class="medgenPMjournal">Circulation</span>
|
||
1996 Oct 15;94(8):1894-901.
|
||
doi: 10.1161/01.cir.94.8.1894.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8873665" target="_blank">8873665</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1567626">Modifying myocardial management in cardiac surgery: a randomized trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fontan F,
|
||
Madonna F,
|
||
Naftel DC,
|
||
Kirklin JW,
|
||
Blackstone EH,
|
||
Digerness S</span><br />
|
||
<span class="medgenPMjournal">Eur J Cardiothorac Surg</span>
|
||
1992;6(3):127-36; discussion 136-7.
|
||
doi: 10.1016/1010-7940(92)90118-h.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1567626" target="_blank">1567626</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Increased%20circulating%20creatine%20kinase%20MB%20isoform%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (56)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37037296">The liver and blood cells are responsible for creatine kinase clearance in blood Circulation: A retrospective study among different human diseases.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pan N,
|
||
Wu Y,
|
||
Yang B,
|
||
Zhang M,
|
||
He Y,
|
||
Wang Z,
|
||
Tan L,
|
||
Zhang L</span><br />
|
||
<span class="medgenPMjournal">Clin Chim Acta</span>
|
||
2023 Apr 1;544:117335.
|
||
Epub 2023 Apr 8
|
||
doi: 10.1016/j.cca.2023.117335.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37037296" target="_blank">37037296</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32206064">Downregulation of miR-483-5p decreases hypoxia-induced injury in human cardiomyocytes by targeting MAPK3.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hao Y,
|
||
Yuan H,
|
||
Yu H</span><br />
|
||
<span class="medgenPMjournal">Cell Mol Biol Lett</span>
|
||
2020;25:20.
|
||
Epub 2020 Mar 17
|
||
doi: 10.1186/s11658-020-00213-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32206064" target="_blank">32206064</a><a href="/pmc/articles/PMC7079484" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10726816">The specificity of biochemical markers of cardiac damage: a problem solved.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Apple FS</span><br />
|
||
<span class="medgenPMjournal">Clin Chem Lab Med</span>
|
||
1999 Nov-Dec;37(11-12):1085-9.
|
||
doi: 10.1515/CCLM.1999.158.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10726816" target="_blank">10726816</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8994739">Creatine kinase isoforms as circulating markers of deterioration in idiopathic dilated cardiomyopathy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hossein-Nia M,
|
||
Baig K,
|
||
Goldman JH,
|
||
Keeling PJ,
|
||
Caforio AL,
|
||
Holt DW,
|
||
McKenna WJ</span><br />
|
||
<span class="medgenPMjournal">Clin Cardiol</span>
|
||
1997 Jan;20(1):55-60.
|
||
doi: 10.1002/clc.4960200112.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8994739" target="_blank">8994739</a><a href="/pmc/articles/PMC6656144" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8198386">The earliest diagnosis of acute myocardial infarction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rozenman Y,
|
||
Gotsman MS</span><br />
|
||
<span class="medgenPMjournal">Annu Rev Med</span>
|
||
1994;45:31-44.
|
||
doi: 10.1146/annurev.med.45.1.31.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8198386" target="_blank">8198386</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Increased%20circulating%20creatine%20kinase%20MB%20isoform%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (44)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/29281146">Comparison of the inflammatory and stress response between sprint interval swimming and running.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Casuso RA,
|
||
Aragon-Vela J,
|
||
Huertas JR,
|
||
Ruiz-Ariza A,
|
||
Martínez-Lopez EJ</span><br />
|
||
<span class="medgenPMjournal">Scand J Med Sci Sports</span>
|
||
2018 Apr;28(4):1371-1378.
|
||
Epub 2018 Jan 24
|
||
doi: 10.1111/sms.13046.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29281146" target="_blank">29281146</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15249498">Anti-Xa activity relates to survival and efficacy in unselected acute coronary syndrome patients treated with enoxaparin.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Montalescot G,
|
||
Collet JP,
|
||
Tanguy ML,
|
||
Ankri A,
|
||
Payot L,
|
||
Dumaine R,
|
||
Choussat R,
|
||
Beygui F,
|
||
Gallois V,
|
||
Thomas D</span><br />
|
||
<span class="medgenPMjournal">Circulation</span>
|
||
2004 Jul 27;110(4):392-8.
|
||
Epub 2004 Jul 12
|
||
doi: 10.1161/01.CIR.0000136830.65073.C7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15249498" target="_blank">15249498</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12208794">Death following creatine kinase-MB elevation after coronary intervention: identification of an early risk period: importance of creatine kinase-MB level, completeness of revascularization, ventricular function, and probable benefit of statin therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ellis SG,
|
||
Chew D,
|
||
Chan A,
|
||
Whitlow PL,
|
||
Schneider JP,
|
||
Topol EJ</span><br />
|
||
<span class="medgenPMjournal">Circulation</span>
|
||
2002 Sep 3;106(10):1205-10.
|
||
doi: 10.1161/01.cir.0000028146.71416.2e.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12208794" target="_blank">12208794</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1567626">Modifying myocardial management in cardiac surgery: a randomized trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fontan F,
|
||
Madonna F,
|
||
Naftel DC,
|
||
Kirklin JW,
|
||
Blackstone EH,
|
||
Digerness S</span><br />
|
||
<span class="medgenPMjournal">Eur J Cardiothorac Surg</span>
|
||
1992;6(3):127-36; discussion 136-7.
|
||
doi: 10.1016/1010-7940(92)90118-h.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1567626" target="_blank">1567626</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/4026489">Time course of serum cardiac enzymes after intracoronary thrombolytic therapy. Creatine kinase, creatine kinase MB isozyme, lactate dehydrogenase, and serum glutamic-oxaloacetic transaminase.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wei JY,
|
||
Markis JE,
|
||
Malagold M,
|
||
Grossman W</span><br />
|
||
<span class="medgenPMjournal">Arch Intern Med</span>
|
||
1985 Sep;145(9):1596-600.
|
||
<span class="bold">PMID: </span><a href="/pubmed/4026489" target="_blank">4026489</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Increased%20circulating%20creatine%20kinase%20MB%20isoform%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (37)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/16008158">Prognostic significance of creatine kinase release after percutaneous coronary intervention.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cavallini C,
|
||
Rugolotto M,
|
||
Savonitto S</span><br />
|
||
<span class="medgenPMjournal">Ital Heart J</span>
|
||
2005 Jun;6(6):522-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16008158" target="_blank">16008158</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15249498">Anti-Xa activity relates to survival and efficacy in unselected acute coronary syndrome patients treated with enoxaparin.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Montalescot G,
|
||
Collet JP,
|
||
Tanguy ML,
|
||
Ankri A,
|
||
Payot L,
|
||
Dumaine R,
|
||
Choussat R,
|
||
Beygui F,
|
||
Gallois V,
|
||
Thomas D</span><br />
|
||
<span class="medgenPMjournal">Circulation</span>
|
||
2004 Jul 27;110(4):392-8.
|
||
Epub 2004 Jul 12
|
||
doi: 10.1161/01.CIR.0000136830.65073.C7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15249498" target="_blank">15249498</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11827918">Minor myocardial damage and prognosis: are spontaneous and percutaneous coronary intervention-related events different?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Akkerhuis KM,
|
||
Alexander JH,
|
||
Tardiff BE,
|
||
Boersma E,
|
||
Harrington RA,
|
||
Lincoff AM,
|
||
Simoons ML</span><br />
|
||
<span class="medgenPMjournal">Circulation</span>
|
||
2002 Feb 5;105(5):554-6.
|
||
doi: 10.1161/hc0502.104278.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11827918" target="_blank">11827918</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10595951">Creatine kinase-MB enzyme elevation following successful saphenous vein graft intervention is associated with late mortality.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hong MK,
|
||
Mehran R,
|
||
Dangas G,
|
||
Mintz GS,
|
||
Lansky AJ,
|
||
Pichard AD,
|
||
Kent KM,
|
||
Satler LF,
|
||
Stone GW,
|
||
Leon MB</span><br />
|
||
<span class="medgenPMjournal">Circulation</span>
|
||
1999 Dec 14;100(24):2400-5.
|
||
doi: 10.1161/01.cir.100.24.2400.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10595951" target="_blank">10595951</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8994739">Creatine kinase isoforms as circulating markers of deterioration in idiopathic dilated cardiomyopathy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hossein-Nia M,
|
||
Baig K,
|
||
Goldman JH,
|
||
Keeling PJ,
|
||
Caforio AL,
|
||
Holt DW,
|
||
McKenna WJ</span><br />
|
||
<span class="medgenPMjournal">Clin Cardiol</span>
|
||
1997 Jan;20(1):55-60.
|
||
doi: 10.1002/clc.4960200112.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8994739" target="_blank">8994739</a><a href="/pmc/articles/PMC6656144" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Increased%20circulating%20creatine%20kinase%20MB%20isoform%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (33)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37037296">The liver and blood cells are responsible for creatine kinase clearance in blood Circulation: A retrospective study among different human diseases.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pan N,
|
||
Wu Y,
|
||
Yang B,
|
||
Zhang M,
|
||
He Y,
|
||
Wang Z,
|
||
Tan L,
|
||
Zhang L</span><br />
|
||
<span class="medgenPMjournal">Clin Chim Acta</span>
|
||
2023 Apr 1;544:117335.
|
||
Epub 2023 Apr 8
|
||
doi: 10.1016/j.cca.2023.117335.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37037296" target="_blank">37037296</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16008158">Prognostic significance of creatine kinase release after percutaneous coronary intervention.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cavallini C,
|
||
Rugolotto M,
|
||
Savonitto S</span><br />
|
||
<span class="medgenPMjournal">Ital Heart J</span>
|
||
2005 Jun;6(6):522-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16008158" target="_blank">16008158</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15249498">Anti-Xa activity relates to survival and efficacy in unselected acute coronary syndrome patients treated with enoxaparin.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Montalescot G,
|
||
Collet JP,
|
||
Tanguy ML,
|
||
Ankri A,
|
||
Payot L,
|
||
Dumaine R,
|
||
Choussat R,
|
||
Beygui F,
|
||
Gallois V,
|
||
Thomas D</span><br />
|
||
<span class="medgenPMjournal">Circulation</span>
|
||
2004 Jul 27;110(4):392-8.
|
||
Epub 2004 Jul 12
|
||
doi: 10.1161/01.CIR.0000136830.65073.C7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15249498" target="_blank">15249498</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10595951">Creatine kinase-MB enzyme elevation following successful saphenous vein graft intervention is associated with late mortality.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hong MK,
|
||
Mehran R,
|
||
Dangas G,
|
||
Mintz GS,
|
||
Lansky AJ,
|
||
Pichard AD,
|
||
Kent KM,
|
||
Satler LF,
|
||
Stone GW,
|
||
Leon MB</span><br />
|
||
<span class="medgenPMjournal">Circulation</span>
|
||
1999 Dec 14;100(24):2400-5.
|
||
doi: 10.1161/01.cir.100.24.2400.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10595951" target="_blank">10595951</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1567626">Modifying myocardial management in cardiac surgery: a randomized trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fontan F,
|
||
Madonna F,
|
||
Naftel DC,
|
||
Kirklin JW,
|
||
Blackstone EH,
|
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Digerness S</span><br />
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<span class="medgenPMjournal">Eur J Cardiothorac Surg</span>
|
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1992;6(3):127-36; discussion 136-7.
|
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doi: 10.1016/1010-7940(92)90118-h.
|
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<span class="bold">PMID: </span><a href="/pubmed/1567626" target="_blank">1567626</a></div>
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