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<meta name="keywords" content="C4725671, high risk neuroblastoma, high-risk neuroblastoma, neoplastic process, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Neuroblastoma usually presenting with metastatic disease and MYCN gene amplifications." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
UID=1654932
ConceptID=C4725671
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">High Risk Neuroblastoma</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1654932</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4725671</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
<td>High-Risk Neuroblastoma</td></tr>
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">Neuroblastoma usually presenting with metastatic disease and MYCN gene amplifications. [from <a title="NCI Thesaurus" href="http://ncit.nci.nih.gov" class="defSource" target="_blank">NCI</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">High Risk Neuroblastoma</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/10294" ref="tree=MeSH" title="MedGen record for Neoplasm">Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/45034" ref="tree=MeSH" title="MedGen record for Embryonal neoplasm">Embryonal neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/234214" ref="tree=MeSH" title="MedGen record for Central Nervous System Embryonal Tumor">Central Nervous System Embryonal Tumor</a></span><ul><li><span class="TLline"><a href="/medgen/1389430" ref="tree=MeSH" title="MedGen record for Central nervous system Ewing sarcoma/peripheral primitive neuroectodermal tumor">Central nervous system Ewing sarcoma/peripheral primitive neuroectodermal tumor</a></span><ul><li><span class="TLline"><a href="/medgen/18012" ref="tree=MeSH" title="MedGen record for Neuroblastoma">Neuroblastoma</a></span><ul><li><span class="matched_ds">High Risk Neuroblastoma</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/36546323">Isotretinoin-induced psychosis in a child on treatment for high-risk neuroblastoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Greenwell AM,
Gorsi HS</span><br />
<span class="medgenPMjournal">Pediatr Blood Cancer</span>
2023 Apr;70(4):e30142.
Epub 2022 Dec 22
doi: 10.1002/pbc.30142.
<span class="bold">PMID: </span><a href="/pubmed/36546323" target="_blank">36546323</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35441788">Rethinking high-risk neuroblastoma treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cohn SL,
Pearson ADJ</span><br />
<span class="medgenPMjournal">Pediatr Blood Cancer</span>
2022 Aug;69(8):e29730.
Epub 2022 Apr 20
doi: 10.1002/pbc.29730.
<span class="bold">PMID: </span><a href="/pubmed/35441788" target="_blank">35441788</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28142287">Overview and recent advances in the treatment of neuroblastoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Whittle SB,
Smith V,
Doherty E,
Zhao S,
McCarty S,
Zage PE</span><br />
<span class="medgenPMjournal">Expert Rev Anticancer Ther</span>
2017 Apr;17(4):369-386.
Epub 2017 Mar 15
doi: 10.1080/14737140.2017.1285230.
<span class="bold">PMID: </span><a href="/pubmed/28142287" target="_blank">28142287</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22high%20risk%20neuroblastoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (100)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/37018492">GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Del Bufalo F,
De Angelis B,
Caruana I,
Del Baldo G,
De Ioris MA,
Serra A,
Mastronuzzi A,
Cefalo MG,
Pagliara D,
Amicucci M,
Li Pira G,
Leone G,
Bertaina V,
Sinibaldi M,
Di Cecca S,
Guercio M,
Abbaszadeh Z,
Iaffaldano L,
Gunetti M,
Iacovelli S,
Bugianesi R,
Macchia S,
Algeri M,
Merli P,
Galaverna F,
Abbas R,
Garganese MC,
Villani MF,
Colafati GS,
Bonetti F,
Rabusin M,
Perruccio K,
Folsi V,
Quintarelli C,
Locatelli F;
Precision Medicine Team–IRCCS Ospedale Pediatrico Bambino Gesù</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2023 Apr 6;388(14):1284-1295.
doi: 10.1056/NEJMoa2210859.
<span class="bold">PMID: </span><a href="/pubmed/37018492" target="_blank">37018492</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36063183">Imaging in neuroblastoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Littooij AS,
de Keizer B</span><br />
<span class="medgenPMjournal">Pediatr Radiol</span>
2023 Apr;53(4):783-787.
Epub 2022 Sep 5
doi: 10.1007/s00247-022-05489-2.
<span class="bold">PMID: </span><a href="/pubmed/36063183" target="_blank">36063183</a><a href="/pmc/articles/PMC10027638" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35522915">High-Risk and Relapsed Neuroblastoma: Toward More Cures and Better Outcomes.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">DuBois SG,
Macy ME,
Henderson TO</span><br />
<span class="medgenPMjournal">Am Soc Clin Oncol Educ Book</span>
2022 Apr;42:1-13.
doi: 10.1200/EDBK_349783.
<span class="bold">PMID: </span><a href="/pubmed/35522915" target="_blank">35522915</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35435953">Immunotherapy of Neuroblastoma: Facts and Hopes.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Anderson J,
Majzner RG,
Sondel PM</span><br />
<span class="medgenPMjournal">Clin Cancer Res</span>
2022 Aug 2;28(15):3196-3206.
doi: 10.1158/1078-0432.CCR-21-1356.
<span class="bold">PMID: </span><a href="/pubmed/35435953" target="_blank">35435953</a><a href="/pmc/articles/PMC9344822" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33616889">Naxitamab: First Approval.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Markham A</span><br />
<span class="medgenPMjournal">Drugs</span>
2021 Feb;81(2):291-296.
doi: 10.1007/s40265-021-01467-4.
<span class="bold">PMID: </span><a href="/pubmed/33616889" target="_blank">33616889</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22High%20Risk%20Neuroblastoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1180)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/39083807">Identification and Characterization of Chemotherapy-Resistant High-Risk Neuroblastoma Persister Cells.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Grossmann LD,
Chen CH,
Uzun Y,
Thadi A,
Wolpaw AJ,
Louault K,
Goldstein Y,
Surrey LF,
Martinez D,
Calafatti M,
Gerelus M,
Gao P,
Lee L,
Patel K,
Kaufman RS,
Shani G,
Farrel A,
Moshitch-Moshkovitz S,
Grimaldi P,
Shapiro M,
Kendsersky NM,
Lindsay JM,
Casey CE,
Krytska K,
Scolaro L,
Tsang M,
Groff D,
Matkar S,
Kalna JR,
Mycek E,
McDevitt J,
Runbeck E,
Patel T,
Bernt KM,
Asgharzadeh S,
DeClerck YA,
Mossé YP,
Tan K,
Maris JM</span><br />
<span class="medgenPMjournal">Cancer Discov</span>
2024 Dec 2;14(12):2387-2406.
doi: 10.1158/2159-8290.CD-24-0046.
<span class="bold">PMID: </span><a href="/pubmed/39083807" target="_blank">39083807</a><a href="/pmc/articles/PMC11609622" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37169874">Clonal evolution during metastatic spread in high-risk neuroblastoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gundem G,
Levine MF,
Roberts SS,
Cheung IY,
Medina-Martínez JS,
Feng Y,
Arango-Ossa JE,
Chadoutaud L,
Rita M,
Asimomitis G,
Zhou J,
You D,
Bouvier N,
Spitzer B,
Solit DB,
Dela Cruz F,
LaQuaglia MP,
Kushner BH,
Modak S,
Shukla N,
Iacobuzio-Donahue CA,
Kung AL,
Cheung NV,
Papaemmanuil E</span><br />
<span class="medgenPMjournal">Nat Genet</span>
2023 Jun;55(6):1022-1033.
Epub 2023 May 11
doi: 10.1038/s41588-023-01395-x.
<span class="bold">PMID: </span><a href="/pubmed/37169874" target="_blank">37169874</a><a href="/pmc/articles/PMC11481711" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36063183">Imaging in neuroblastoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Littooij AS,
de Keizer B</span><br />
<span class="medgenPMjournal">Pediatr Radiol</span>
2023 Apr;53(4):783-787.
Epub 2022 Sep 5
doi: 10.1007/s00247-022-05489-2.
<span class="bold">PMID: </span><a href="/pubmed/36063183" target="_blank">36063183</a><a href="/pmc/articles/PMC10027638" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35522915">High-Risk and Relapsed Neuroblastoma: Toward More Cures and Better Outcomes.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">DuBois SG,
Macy ME,
Henderson TO</span><br />
<span class="medgenPMjournal">Am Soc Clin Oncol Educ Book</span>
2022 Apr;42:1-13.
doi: 10.1200/EDBK_349783.
<span class="bold">PMID: </span><a href="/pubmed/35522915" target="_blank">35522915</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28142287">Overview and recent advances in the treatment of neuroblastoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Whittle SB,
Smith V,
Doherty E,
Zhao S,
McCarty S,
Zage PE</span><br />
<span class="medgenPMjournal">Expert Rev Anticancer Ther</span>
2017 Apr;17(4):369-386.
Epub 2017 Mar 15
doi: 10.1080/14737140.2017.1285230.
<span class="bold">PMID: </span><a href="/pubmed/28142287" target="_blank">28142287</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22High%20Risk%20Neuroblastoma%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (467)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/38696315">Eflornithine (Iwilfin) for high-risk neuroblastoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMjournal">Med Lett Drugs Ther</span>
2024 May 13;66(1702):e81-e82.
doi: 10.58347/tml.2024.1702f.
<span class="bold">PMID: </span><a href="/pubmed/38696315" target="_blank">38696315</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37018492">GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Del Bufalo F,
De Angelis B,
Caruana I,
Del Baldo G,
De Ioris MA,
Serra A,
Mastronuzzi A,
Cefalo MG,
Pagliara D,
Amicucci M,
Li Pira G,
Leone G,
Bertaina V,
Sinibaldi M,
Di Cecca S,
Guercio M,
Abbaszadeh Z,
Iaffaldano L,
Gunetti M,
Iacovelli S,
Bugianesi R,
Macchia S,
Algeri M,
Merli P,
Galaverna F,
Abbas R,
Garganese MC,
Villani MF,
Colafati GS,
Bonetti F,
Rabusin M,
Perruccio K,
Folsi V,
Quintarelli C,
Locatelli F;
Precision Medicine Team–IRCCS Ospedale Pediatrico Bambino Gesù</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2023 Apr 6;388(14):1284-1295.
doi: 10.1056/NEJMoa2210859.
<span class="bold">PMID: </span><a href="/pubmed/37018492" target="_blank">37018492</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35522915">High-Risk and Relapsed Neuroblastoma: Toward More Cures and Better Outcomes.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">DuBois SG,
Macy ME,
Henderson TO</span><br />
<span class="medgenPMjournal">Am Soc Clin Oncol Educ Book</span>
2022 Apr;42:1-13.
doi: 10.1200/EDBK_349783.
<span class="bold">PMID: </span><a href="/pubmed/35522915" target="_blank">35522915</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35435953">Immunotherapy of Neuroblastoma: Facts and Hopes.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Anderson J,
Majzner RG,
Sondel PM</span><br />
<span class="medgenPMjournal">Clin Cancer Res</span>
2022 Aug 2;28(15):3196-3206.
doi: 10.1158/1078-0432.CCR-21-1356.
<span class="bold">PMID: </span><a href="/pubmed/35435953" target="_blank">35435953</a><a href="/pmc/articles/PMC9344822" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35327550">Anti-GD2 Directed Immunotherapy for High-Risk and Metastatic Neuroblastoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chan GC,
Chan CM</span><br />
<span class="medgenPMjournal">Biomolecules</span>
2022 Feb 24;12(3)
doi: 10.3390/biom12030358.
<span class="bold">PMID: </span><a href="/pubmed/35327550" target="_blank">35327550</a><a href="/pmc/articles/PMC8945428" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22High%20Risk%20Neuroblastoma%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (619)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/36063183">Imaging in neuroblastoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Littooij AS,
de Keizer B</span><br />
<span class="medgenPMjournal">Pediatr Radiol</span>
2023 Apr;53(4):783-787.
Epub 2022 Sep 5
doi: 10.1007/s00247-022-05489-2.
<span class="bold">PMID: </span><a href="/pubmed/36063183" target="_blank">36063183</a><a href="/pmc/articles/PMC10027638" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35522915">High-Risk and Relapsed Neuroblastoma: Toward More Cures and Better Outcomes.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">DuBois SG,
Macy ME,
Henderson TO</span><br />
<span class="medgenPMjournal">Am Soc Clin Oncol Educ Book</span>
2022 Apr;42:1-13.
doi: 10.1200/EDBK_349783.
<span class="bold">PMID: </span><a href="/pubmed/35522915" target="_blank">35522915</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33818884">Neuroblastoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chung C,
Boterberg T,
Lucas J,
Panoff J,
Valteau-Couanet D,
Hero B,
Bagatell R,
Hill-Kayser CE</span><br />
<span class="medgenPMjournal">Pediatr Blood Cancer</span>
2021 May;68 Suppl 2(Suppl 2):e28473.
doi: 10.1002/pbc.28473.
<span class="bold">PMID: </span><a href="/pubmed/33818884" target="_blank">33818884</a><a href="/pmc/articles/PMC8785544" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33504555">Long-Term Follow-up of a Phase III Study of ch14.18 (Dinutuximab) + Cytokine Immunotherapy in Children with High-Risk Neuroblastoma: COG Study ANBL0032.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yu AL,
Gilman AL,
Ozkaynak MF,
Naranjo A,
Diccianni MB,
Gan J,
Hank JA,
Batova A,
London WB,
Tenney SC,
Smith M,
Shulkin BL,
Parisi M,
Matthay KK,
Cohn SL,
Maris JM,
Bagatell R,
Park JR,
Sondel PM</span><br />
<span class="medgenPMjournal">Clin Cancer Res</span>
2021 Apr 15;27(8):2179-2189.
Epub 2021 Jan 27
doi: 10.1158/1078-0432.CCR-20-3909.
<span class="bold">PMID: </span><a href="/pubmed/33504555" target="_blank">33504555</a><a href="/pmc/articles/PMC8046731" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28142287">Overview and recent advances in the treatment of neuroblastoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Whittle SB,
Smith V,
Doherty E,
Zhao S,
McCarty S,
Zage PE</span><br />
<span class="medgenPMjournal">Expert Rev Anticancer Ther</span>
2017 Apr;17(4):369-386.
Epub 2017 Mar 15
doi: 10.1080/14737140.2017.1285230.
<span class="bold">PMID: </span><a href="/pubmed/28142287" target="_blank">28142287</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22High%20Risk%20Neuroblastoma%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (564)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/37883734">Eflornithine as Postimmunotherapy Maintenance in High-Risk Neuroblastoma: Externally Controlled, Propensity Score-Matched Survival Outcome Comparisons.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Oesterheld J,
Ferguson W,
Kraveka JM,
Bergendahl G,
Clinch T,
Lorenzi E,
Berry D,
Wada RK,
Isakoff MS,
Eslin DE,
Brown VI,
Roberts W,
Zage P,
Harrod VL,
Mitchell DS,
Hanson D,
Saulnier Sholler GL</span><br />
<span class="medgenPMjournal">J Clin Oncol</span>
2024 Jan 1;42(1):90-102.
Epub 2023 Oct 26
doi: 10.1200/JCO.22.02875.
<span class="bold">PMID: </span><a href="/pubmed/37883734" target="_blank">37883734</a><a href="/pmc/articles/PMC10730038" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37018492">GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Del Bufalo F,
De Angelis B,
Caruana I,
Del Baldo G,
De Ioris MA,
Serra A,
Mastronuzzi A,
Cefalo MG,
Pagliara D,
Amicucci M,
Li Pira G,
Leone G,
Bertaina V,
Sinibaldi M,
Di Cecca S,
Guercio M,
Abbaszadeh Z,
Iaffaldano L,
Gunetti M,
Iacovelli S,
Bugianesi R,
Macchia S,
Algeri M,
Merli P,
Galaverna F,
Abbas R,
Garganese MC,
Villani MF,
Colafati GS,
Bonetti F,
Rabusin M,
Perruccio K,
Folsi V,
Quintarelli C,
Locatelli F;
Precision Medicine Team–IRCCS Ospedale Pediatrico Bambino Gesù</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2023 Apr 6;388(14):1284-1295.
doi: 10.1056/NEJMoa2210859.
<span class="bold">PMID: </span><a href="/pubmed/37018492" target="_blank">37018492</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35197583">Cellular senescence in neuroblastoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zanotti S,
Decaesteker B,
Vanhauwaert S,
De Wilde B,
De Vos WH,
Speleman F</span><br />
<span class="medgenPMjournal">Br J Cancer</span>
2022 Jun;126(11):1529-1538.
Epub 2022 Feb 23
doi: 10.1038/s41416-022-01755-0.
<span class="bold">PMID: </span><a href="/pubmed/35197583" target="_blank">35197583</a><a href="/pmc/articles/PMC9130206" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33504555">Long-Term Follow-up of a Phase III Study of ch14.18 (Dinutuximab) + Cytokine Immunotherapy in Children with High-Risk Neuroblastoma: COG Study ANBL0032.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yu AL,
Gilman AL,
Ozkaynak MF,
Naranjo A,
Diccianni MB,
Gan J,
Hank JA,
Batova A,
London WB,
Tenney SC,
Smith M,
Shulkin BL,
Parisi M,
Matthay KK,
Cohn SL,
Maris JM,
Bagatell R,
Park JR,
Sondel PM</span><br />
<span class="medgenPMjournal">Clin Cancer Res</span>
2021 Apr 15;27(8):2179-2189.
Epub 2021 Jan 27
doi: 10.1158/1078-0432.CCR-20-3909.
<span class="bold">PMID: </span><a href="/pubmed/33504555" target="_blank">33504555</a><a href="/pmc/articles/PMC8046731" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/20879881">Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yu AL,
Gilman AL,
Ozkaynak MF,
London WB,
Kreissman SG,
Chen HX,
Smith M,
Anderson B,
Villablanca JG,
Matthay KK,
Shimada H,
Grupp SA,
Seeger R,
Reynolds CP,
Buxton A,
Reisfeld RA,
Gillies SD,
Cohn SL,
Maris JM,
Sondel PM;
Children's Oncology Group</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2010 Sep 30;363(14):1324-34.
doi: 10.1056/NEJMoa0911123.
<span class="bold">PMID: </span><a href="/pubmed/20879881" target="_blank">20879881</a><a href="/pmc/articles/PMC3086629" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22High%20Risk%20Neuroblastoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (372)</a></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/30822684">A systematic review of re-induction chemotherapy for children with relapsed high-risk neuroblastoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Herd F,
Basta NO,
McNally RJQ,
Tweddle DA</span><br />
<span class="medgenPMjournal">Eur J Cancer</span>
2019 Apr;111:50-58.
Epub 2019 Feb 26
doi: 10.1016/j.ejca.2018.12.032.
<span class="bold">PMID: </span><a href="/pubmed/30822684" target="_blank">30822684</a><a href="/pmc/articles/PMC6458963" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30509728">The Evidence for External Beam Radiotherapy in High-Risk Neuroblastoma of Childhood: A Systematic Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Arumugam S,
Manning-Cork NJ,
Gains JE,
Boterberg T,
Gaze MN</span><br />
<span class="medgenPMjournal">Clin Oncol (R Coll Radiol)</span>
2019 Mar;31(3):182-190.
Epub 2018 Dec 1
doi: 10.1016/j.clon.2018.11.031.
<span class="bold">PMID: </span><a href="/pubmed/30509728" target="_blank">30509728</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30262202">Impact of extent of resection on survival in high-risk neuroblastoma: A systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yang X,
Chen J,
Wang N,
Liu Z,
Li F,
Zhou J,
Tao B</span><br />
<span class="medgenPMjournal">J Pediatr Surg</span>
2019 Jul;54(7):1487-1494.
Epub 2018 Sep 6
doi: 10.1016/j.jpedsurg.2018.08.046.
<span class="bold">PMID: </span><a href="/pubmed/30262202" target="_blank">30262202</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28840597">Retinoic acid postconsolidation therapy for high-risk neuroblastoma patients treated with autologous haematopoietic stem cell transplantation.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Peinemann F,
van Dalen EC,
Enk H,
Berthold F</span><br />
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
2017 Aug 25;8(8):CD010685.
doi: 10.1002/14651858.CD010685.pub3.
<span class="bold">PMID: </span><a href="/pubmed/28840597" target="_blank">28840597</a><a href="/pmc/articles/PMC6483698" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25989478">Rapid COJEC versus standard induction therapies for high-risk neuroblastoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Peinemann F,
Tushabe DA,
van Dalen EC,
Berthold F</span><br />
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
2015 May 19;2015(5):CD010774.
doi: 10.1002/14651858.CD010774.pub2.
<span class="bold">PMID: </span><a href="/pubmed/25989478" target="_blank">25989478</a><a href="/pmc/articles/PMC10501324" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22High%20Risk%20Neuroblastoma%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (13)</a></div></div>
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<p class="address_footer text-white">National Library of Medicine<br />
<a href="https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323" class="text-white" target="_blank" rel="noopener noreferrer">8600 Rockville Pike<br />
Bethesda, MD 20894</a></p>
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<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
<a href="https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office" class="text-white">FOIA</a><br />
<a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" class="text-white" id="vdp">HHS Vulnerability Disclosure</a></p>
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<div class="col-lg-3 col-12 centered-lg">
<p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br />
<a href="https://www.nlm.nih.gov/accessibility.html" class="text-white">Accessibility</a><br />
<a href="https://www.nlm.nih.gov/careers/careers.html" class="text-white">Careers</a></p>
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<nav class="bottom-links">
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<a class="text-white" href="//www.nlm.nih.gov/">NLM</a>
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<a class="text-white" href="https://www.nih.gov/">NIH</a>
</li>
<li>
<a class="text-white" href="https://www.hhs.gov/">HHS</a>
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<a class="text-white" href="https://www.usa.gov/">USA.gov</a>
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</nav>
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