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<meta name="keywords" content="C4551957, adlte, adpeaf, autosomal dominant lateral temporal lobe epilepsy, autosomal dominant partial epilepsy with auditory features, disease or syndrome, epilepsy, familial temporal lobe 1, epilepsy, familial temporal lobe, 1, epilepsy, familial temporal lobe, type 1, epilepsy, lateral temporal lobe, autosomal dominant, epilepsy, partial, with auditory features, etl1, lgi1, mical1, reln, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Autosomal dominant epilepsy with auditory features (ADEAF) is a focal epilepsy syndrome with auditory symptoms and/or receptive aphasia as prominent ictal manifestations. The most common auditory symptoms are simple unformed sounds including humming, buzzing, or ringing; less common forms are distortions (e.g., volume changes) or complex sounds (e.g., specific songs or voices). Ictal receptive aphasia consists of a sudden onset of inability to understand language in the absence of general confusion. Less commonly, other ictal symptoms may occur, including sensory symptoms (visual, olfactory, vertiginous, or cephalic) or motor, psychic, and autonomic symptoms. Age at onset is usually in adolescence or early adulthood (age 10-30 years). The clinical course of ADEAF is benign. Seizures are usually well controlled after initiation of medical therapy." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=1643229
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ConceptID=C4551957
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Epilepsy, familial temporal lobe, 1<span class="h1sub">(ETL1)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1643229</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4551957</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Autosomal Dominant Partial Epilepsy with Auditory Features</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Genes (locations):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="LGI1 - ID: 9211 - NCBI Gene" href="/gene/9211" class="medgenPMinfo">LGI1</a> (10q23.33); <a target="_blank" title="MICAL1 - ID: 64780 - NCBI Gene" href="/gene/64780" class="medgenPMinfo">MICAL1</a> (6q21); <a target="_blank" title="RELN - ID: 5649 - NCBI Gene" href="/gene/5649" class="medgenPMinfo">RELN</a> (7q22.1)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0700090" target="_blank">MONDO:0700090</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/600512" target="_blank">600512</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_101">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Disease_characteristics">Disease characteristics</h1><a sid="101" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln"><div class="excerpt">Excerpted from the <i>GeneReview: </i><a href="/books/NBK1537" target="_blank">Autosomal Dominant Epilepsy with Auditory Features</a></div><div>Autosomal dominant epilepsy with auditory features (ADEAF) is a focal epilepsy syndrome with auditory symptoms and/or receptive aphasia as prominent ictal manifestations. The most common auditory symptoms are simple unformed sounds including humming, buzzing, or ringing; less common forms are distortions (e.g., volume changes) or complex sounds (e.g., specific songs or voices). Ictal receptive aphasia consists of a sudden onset of inability to understand language in the absence of general confusion. Less commonly, other ictal symptoms may occur, including sensory symptoms (visual, olfactory, vertiginous, or cephalic) or motor, psychic, and autonomic symptoms. Age at onset is usually in adolescence or early adulthood (age 10-30 years). The clinical course of ADEAF is benign. Seizures are usually well controlled after initiation of medical therapy. [from <a title="GeneReviews" href="https://www.ncbi.nlm.nih.gov/books/NBK1116" class="defSource" target="_blank">GeneReviews</a>]</div><div class="spaceAbove"><strong>Full text of <i>GeneReview</i> (by section):</strong><br /><a class="medgenPMinfo" href="/books/NBK1537#peaf.Summary" target="NBK1537">Summary</a> | <a class="medgenPMinfo" href="/books/NBK1537#peaf.Diagnosis" target="NBK1537">Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK1537#peaf.Clinical_Characteristics" target="NBK1537">Clinical Characteristics</a> | <a class="medgenPMinfo" href="/books/NBK1537#peaf.Genetically_Related_Allelic_Disorde" target="NBK1537">Genetically Related (Allelic) Disorders</a> | <a class="medgenPMinfo" href="/books/NBK1537#peaf.Differential_Diagnosis" target="NBK1537">Differential Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK1537#peaf.Management" target="NBK1537">Management</a> | <a class="medgenPMinfo" href="/books/NBK1537#peaf.Genetic_Counseling" target="NBK1537">Genetic Counseling</a> | <a class="medgenPMinfo" href="/books/NBK1537#peaf.Resources" target="NBK1537">Resources</a> | <a class="medgenPMinfo" href="/books/NBK1537#peaf.Molecular_Genetics" target="NBK1537">Molecular Genetics</a> | <a class="medgenPMinfo" href="/books/NBK1537#peaf.Chapter_Notes" target="NBK1537">Chapter Notes</a> | <a class="medgenPMinfo" href="/books/NBK1537#peaf.References" target="NBK1537">References</a></div><div class="spaceAbove"><strong>Authors:</strong><br />
|
||
Roberto Michelucci | Elena Pasini | Emanuela Dazzo <a href="/books/NBK1537" target="NBK1537" title="NCBI Bookshelf: Autosomal Dominant Epilepsy with Auditory Features">view full author information</a></div></div>
|
||
</div>
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||
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||
<div class="portlet mgSection" id="ID_117">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Additional_descriptions">Additional descriptions</h1><a sid="117" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="mgSection"><strong>From OMIM</strong><br />Autosomal dominant lateral temporal lobe epilepsy is a specific form of temporal lobe epilepsy characterized by partial seizures originating from the temporal lobe. Seizures are usually accompanied by sensory symptoms, most often auditory in nature (summary by Winawer et al., 2000).
|
||
Genetic Heterogeneity of Temporal Lobe Epilepsy
|
||
See also ETL2 (608096), which maps to chromosome 12q; ETL3 (611630), which maps to chromosome 4q; ETL4 (611631), which maps to chromosome 9q; ETL5 (614417), caused by mutation in the CPA6 gene (609562) on chromosome 8q13; ETL6 (615697), which maps to chromosome 3q25-q26; ETL7 (616436), caused by mutation in the RELN gene (600514) on chromosome 7q22; and ETL8 (616461), caused by mutation in the GAL gene (137035) on chromosome 11q13. <a target="_blank" href="http://www.omim.org/entry/600512">http://www.omim.org/entry/600512</a></div><div class="mgSection"><strong>From MedlinePlus Genetics</strong><br />Autosomal dominant epilepsy with auditory features (ADEAF) is an uncommon form of epilepsy that runs in families. People with this condition typically hear sounds (auditory features), such as buzzing, humming, or ringing, during seizures. Some people hear more complex sounds, like specific voices or music, or changes in the volume of sounds. Some people with ADEAF suddenly become unable to understand language before losing consciousness during a seizure. This inability to understand speech is known as receptive aphasia. Less commonly, seizures may cause visual hallucinations, a disturbance in the sense of smell, a feeling of dizziness or spinning (vertigo), or other symptoms that affect the senses.<br /><br />ADEAF is called a focal epilepsy because the seizures start in one part of the brain, rather than involving the entire brain from the beginning. Most people with ADEAF have focal aware seizures, which do not cause a loss of consciousness. These seizures are thought to begin in a part of the brain called the lateral temporal lobe. In some people, seizure activity may spread from the lateral temporal lobe to affect other regions of the brain. If seizure activity spreads to the entire brain, it causes a loss of consciousness, muscle stiffening, and rhythmic jerking. Episodes that begin as focal seizures and spread throughout the brain are known as secondarily generalized seizures.<br /><br />Seizures associated with ADEAF usually begin in adolescence or young adulthood. They may be triggered by specific sounds, such as a ringing telephone or speech, but in most cases the seizures do not have any recognized triggers. In most affected people, seizures are infrequent and effectively controlled with medication. <a target="_blank" href="https://medlineplus.gov/genetics/condition/autosomal-dominant-epilepsy-with-auditory-features">https://medlineplus.gov/genetics/condition/autosomal-dominant-epilepsy-with-auditory-features</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_41442"><div><strong>Deja vu aura</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>41442</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0011194</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Mental Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A subjective feeling that an experience which is occurring for the first time has been experienced before.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen?term=%22Deja%20vu%20aura%22%5BClinical%20Features%5D%20OR%2041442%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_65895"><div><strong>Focal aware seizure</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>65895</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0234974</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A type of focal-onset seizure in which awareness is preserved. Awareness during a seizure is defined as the patient being fully aware of themself and their environment throughout the seizure, even if immobile.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/65895">Feature record</a> | <a href="/medgen?term=%22Focal%20aware%20seizure%22%5BClinical%20Features%5D%20OR%2065895%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_543022"><div><strong>Focal impaired awareness seizure</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>543022</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0270834</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Focal impaired awareness seizure (or focal seizure with impaired or lost awareness) is a type of focal-onset seizure characterized by some degree (which may be partial) of impairment of the person's awareness of themselves or their surroundings at any point during the seizure.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/543022">Feature record</a> | <a href="/medgen?term=%22Focal%20impaired%20awareness%20seizure%22%5BClinical%20Features%5D%20OR%20543022%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_75815"><div><strong>Focal sensory seizure with visual features</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>75815</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0278188</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A seizure characterized by elementary visual hallucinations such as flashing or flickering lights/colors, or other shapes, simple patterns, scotomata, or amaurosis as its first clinical manifestation.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/75815">Feature record</a> | <a href="/medgen?term=%22Focal%20sensory%20seizure%20with%20visual%20features%22%5BClinical%20Features%5D%20OR%2075815%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_140831"><div><strong>Focal sensory seizure with olfactory features</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>140831</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0422853</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Seizures characterized by olfactory phenomena as its first clinical manifestation.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/140831">Feature record</a> | <a href="/medgen?term=%22Focal%20sensory%20seizure%20with%20olfactory%20features%22%5BClinical%20Features%5D%20OR%20140831%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_141670"><div><strong>Bilateral tonic-clonic seizure</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>141670</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0494475</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Sign or Symptom</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A bilateral tonic-clonic seizure is a seizure defined by a tonic (bilateral increased tone, lasting seconds to minutes) and then a clonic (bilateral sustained rhythmic jerking) phase.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/141670">Feature record</a> | <a href="/medgen?term=%22Bilateral%20tonic-clonic%20seizure%22%5BClinical%20Features%5D%20OR%20141670%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_155749"><div><strong>Focal clonic seizure</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>155749</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0752323</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A focal clonic seizure is a type of focal motor seizure characterized by sustained rhythmic jerking, that is regularly repetitive.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/155749">Feature record</a> | <a href="/medgen?term=%22Focal%20clonic%20seizure%22%5BClinical%20Features%5D%20OR%20155749%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_164077"><div><strong>Bilateral tonic-clonic seizure with focal onset</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>164077</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0877017</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A bilateral tonic-clonic seizure with focal onset is a focal-onset seizure which progresses into a bilateral tonic-clonic phase.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/164077">Feature record</a> | <a href="/medgen?term=%22Bilateral%20tonic-clonic%20seizure%20with%20focal%20onset%22%5BClinical%20Features%5D%20OR%20164077%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_373879"><div><strong>Focal sensory seizure with auditory features</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>373879</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1838063</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pathologic Function</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A seizure characterized by elementary auditory phenomena including buzzing, ringing, drumming or single tones as its first clinical manifestation.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/373879">Feature record</a> | <a href="/medgen?term=%22Focal%20sensory%20seizure%20with%20auditory%20features%22%5BClinical%20Features%5D%20OR%20373879%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_869088"><div><strong>Focal autonomic seizure with epigastric sensation/nausea/vomiting/other gastrointestinal phenomena</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>869088</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4023506</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A type of focal autonomic seizure characterized by symptoms or signs pertaining to the gastrointestinal system as the initial semiological feature.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/869088">Feature record</a> | <a href="/medgen?term=%22Focal%20autonomic%20seizure%20with%20epigastric%20sensation%2Fnausea%2Fvomiting%2Fother%20gastrointestinal%20phenomena%22%5BClinical%20Features%5D%20OR%20869088%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1709041"><div><strong>Focal sensory seizure with vestibular features</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1709041</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5397769</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A seizure characterized by symptoms of dizziness, spinning, vertigo or sense of rotation as its first clinical manifestation.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1709041">Feature record</a> | <a href="/medgen?term=%22Focal%20sensory%20seizure%20with%20vestibular%20features%22%5BClinical%20Features%5D%20OR%201709041%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1712446"><div><strong>Focal autonomic seizure with palpitations/tachycardia/bradycardia/asystole</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1712446</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5397783</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A type of focal autonomic seizure characterized by changes in heart rate as the initial semiological feature.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1712446">Feature record</a> | <a href="/medgen?term=%22Focal%20autonomic%20seizure%20with%20palpitations%2Ftachycardia%2Fbradycardia%2Fasystole%22%5BClinical%20Features%5D%20OR%201712446%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1715911"><div><strong>Focal sensory seizure with cephalic sensation</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1715911</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5397816</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A seizure characterized by a sensation in the head such as light-headedness or headache as its first clinical manifestation.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1715911">Feature record</a> | <a href="/medgen?term=%22Focal%20sensory%20seizure%20with%20cephalic%20sensation%22%5BClinical%20Features%5D%20OR%201715911%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1712570"><div><strong>Focal aware sensory seizure with auditory features</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1712570</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5397869</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A type of focal sensory seizure with auditory features during which awareness is retained throughout the seizure.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1712570">Feature record</a> | <a href="/medgen?term=%22Focal%20aware%20sensory%20seizure%20with%20auditory%20features%22%5BClinical%20Features%5D%20OR%201712570%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1718214"><div><strong>Focal automatism seizure</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1718214</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5397903</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A focal seizure characterized at onset by coordinated motor activity. This often resembles a voluntary movement and may consist of an inappropriate continuation of preictal motor activity.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1718214">Feature record</a> | <a href="/medgen?term=%22Focal%20automatism%20seizure%22%5BClinical%20Features%5D%20OR%201718214%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite"><ul><li><span class="TLline">Abnormality of the nervous system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_141670" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bilateral tonic-clonic seizure</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_164077" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bilateral tonic-clonic seizure with focal onset</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_41442" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Deja vu aura</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1718214" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Focal automatism seizure</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_869088" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Focal autonomic seizure with epigastric sensation/nausea/vomiting/other gastrointestinal phenomena</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1712446" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Focal autonomic seizure with palpitations/tachycardia/bradycardia/asystole</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_65895" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Focal aware seizure</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1712570" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Focal aware sensory seizure with auditory features</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_155749" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Focal clonic seizure</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_543022" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Focal impaired awareness seizure</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_373879" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Focal sensory seizure with auditory features</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1715911" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Focal sensory seizure with cephalic sensation</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_140831" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Focal sensory seizure with olfactory features</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1709041" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Focal sensory seizure with vestibular features</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_75815" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Focal sensory seizure with visual features</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1838062[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=325326">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=325326" target="_blank" href="/omim/600512">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=325326" ref="ncbi_uid=325326">V</a></span></span><span class="TLline"><a href="/medgen/325326" ref="tree=GTR&ncbi_uid=325326&link_uid=325326" title="View MedGen record for 'Autosomal dominant epilepsy with auditory features'">Autosomal dominant epilepsy with auditory features</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/976986" ref="tree=GTR&ncbi_uid=976986&link_uid=976986" title="View MedGen record for 'Adolescent/adult onset autosomal dominant epilepsy with auditory features'">Adolescent/adult onset autosomal dominant epilepsy with auditory features</a></span></li><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C4551957[DISCUI]&test_type=Clinical" ref="ncbi_uid=1643229">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=1643229" target="_blank" href="/omim/600512">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1537/" ref="ncbi_uid=1643229">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=1643229" ref="ncbi_uid=1643229">V</a></span></span><span class="TLline">Epilepsy, familial temporal lobe, 1</span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/1826100" ref="tree=MeSH" title="MedGen record for Familial partial epilepsy">Familial partial epilepsy</a></span><ul><li><span class="TLline"><a href="/medgen/325326" ref="tree=MeSH" title="MedGen record for Autosomal dominant epilepsy with auditory features">Autosomal dominant epilepsy with auditory features</a></span><ul><li><span class="matched_ds">Epilepsy, familial temporal lobe, 1</span></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37603261">New GABA-Targeting Therapies for the Treatment of Seizures and Epilepsy: II. Treatments in Clinical Development.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Perucca E,
|
||
White HS,
|
||
Bialer M</span><br />
|
||
<span class="medgenPMjournal">CNS Drugs</span>
|
||
2023 Sep;37(9):781-795.
|
||
Epub 2023 Aug 21
|
||
doi: 10.1007/s40263-023-01025-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37603261" target="_blank">37603261</a><a href="/pmc/articles/PMC10501930" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27979357">Epilepsy research in 2016: new treatment directions.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Berkovic SF</span><br />
|
||
<span class="medgenPMjournal">Lancet Neurol</span>
|
||
2017 Jan;16(1):7-9.
|
||
doi: 10.1016/S1474-4422(16)30334-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27979357" target="_blank">27979357</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/4581416">Recent progress in epilepsy. Diagnostic procedures and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tharp BR</span><br />
|
||
<span class="medgenPMjournal">Calif Med</span>
|
||
1973 Jul;119(1):19-48.
|
||
<span class="bold">PMID: </span><a href="/pubmed/4581416" target="_blank">4581416</a><a href="/pmc/articles/PMC1455405" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(epilepsy%2C%20familial%20temporal%20lobe%2C%201)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (58)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39294238">Machine learning algorithm for predicting seizure control after temporal lobe resection using peri-ictal electroencephalography.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sheikh SR,
|
||
McKee ZA,
|
||
Ghosn S,
|
||
Jeong KS,
|
||
Kattan M,
|
||
Burgess RC,
|
||
Jehi L,
|
||
Saab CY</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2024 Sep 18;14(1):21771.
|
||
doi: 10.1038/s41598-024-72249-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39294238" target="_blank">39294238</a><a href="/pmc/articles/PMC11410994" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37597255">Familial Mesial Temporal Lobe Epilepsy: Clinical Spectrum and Genetic Evidence for a Polygenic Architecture.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Harris RV,
|
||
Oliver KL,
|
||
Perucca P,
|
||
Striano P,
|
||
Labate A,
|
||
Riva A,
|
||
Grinton BE,
|
||
Reid J,
|
||
Hutton J,
|
||
Todaro M,
|
||
O'Brien TJ,
|
||
Kwan P,
|
||
Sadleir LG,
|
||
Mullen SA,
|
||
Dazzo E,
|
||
Crompton DE,
|
||
Scheffer IE,
|
||
Bahlo M,
|
||
Nobile C,
|
||
Gambardella A,
|
||
Berkovic SF</span><br />
|
||
<span class="medgenPMjournal">Ann Neurol</span>
|
||
2023 Nov;94(5):825-835.
|
||
Epub 2023 Aug 31
|
||
doi: 10.1002/ana.26765.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37597255" target="_blank">37597255</a><a href="/pmc/articles/PMC10952415" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35987094">Detecting temporal lobe seizures in ultra long-term subcutaneous EEG using algorithm-based data reduction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Remvig LS,
|
||
Duun-Henriksen J,
|
||
Fürbass F,
|
||
Hartmann M,
|
||
Viana PF,
|
||
Kappel Overby AM,
|
||
Weisdorf S,
|
||
Richardson MP,
|
||
Beniczky S,
|
||
Kjaer TW</span><br />
|
||
<span class="medgenPMjournal">Clin Neurophysiol</span>
|
||
2022 Oct;142:86-93.
|
||
Epub 2022 Aug 8
|
||
doi: 10.1016/j.clinph.2022.07.504.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35987094" target="_blank">35987094</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23027091">Mesial temporal lobe epilepsy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tatum WO 4th</span><br />
|
||
<span class="medgenPMjournal">J Clin Neurophysiol</span>
|
||
2012 Oct;29(5):356-65.
|
||
doi: 10.1097/WNP.0b013e31826b3ab7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23027091" target="_blank">23027091</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10570755">Temporal lobe epilepsy, temporal lobectomy, and major depression.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Altshuler L,
|
||
Rausch R,
|
||
Delrahim S,
|
||
Kay J,
|
||
Crandall P</span><br />
|
||
<span class="medgenPMjournal">J Neuropsychiatry Clin Neurosci</span>
|
||
1999 Fall;11(4):436-43.
|
||
doi: 10.1176/jnp.11.4.436.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10570755" target="_blank">10570755</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Epilepsy%2C%20familial%20temporal%20lobe%2C%201%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2073)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37597255">Familial Mesial Temporal Lobe Epilepsy: Clinical Spectrum and Genetic Evidence for a Polygenic Architecture.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Harris RV,
|
||
Oliver KL,
|
||
Perucca P,
|
||
Striano P,
|
||
Labate A,
|
||
Riva A,
|
||
Grinton BE,
|
||
Reid J,
|
||
Hutton J,
|
||
Todaro M,
|
||
O'Brien TJ,
|
||
Kwan P,
|
||
Sadleir LG,
|
||
Mullen SA,
|
||
Dazzo E,
|
||
Crompton DE,
|
||
Scheffer IE,
|
||
Bahlo M,
|
||
Nobile C,
|
||
Gambardella A,
|
||
Berkovic SF</span><br />
|
||
<span class="medgenPMjournal">Ann Neurol</span>
|
||
2023 Nov;94(5):825-835.
|
||
Epub 2023 Aug 31
|
||
doi: 10.1002/ana.26765.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37597255" target="_blank">37597255</a><a href="/pmc/articles/PMC10952415" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35987094">Detecting temporal lobe seizures in ultra long-term subcutaneous EEG using algorithm-based data reduction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Remvig LS,
|
||
Duun-Henriksen J,
|
||
Fürbass F,
|
||
Hartmann M,
|
||
Viana PF,
|
||
Kappel Overby AM,
|
||
Weisdorf S,
|
||
Richardson MP,
|
||
Beniczky S,
|
||
Kjaer TW</span><br />
|
||
<span class="medgenPMjournal">Clin Neurophysiol</span>
|
||
2022 Oct;142:86-93.
|
||
Epub 2022 Aug 8
|
||
doi: 10.1016/j.clinph.2022.07.504.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35987094" target="_blank">35987094</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33028830">Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pfisterer U,
|
||
Petukhov V,
|
||
Demharter S,
|
||
Meichsner J,
|
||
Thompson JJ,
|
||
Batiuk MY,
|
||
Asenjo-Martinez A,
|
||
Vasistha NA,
|
||
Thakur A,
|
||
Mikkelsen J,
|
||
Adorjan I,
|
||
Pinborg LH,
|
||
Pers TH,
|
||
von Engelhardt J,
|
||
Kharchenko PV,
|
||
Khodosevich K</span><br />
|
||
<span class="medgenPMjournal">Nat Commun</span>
|
||
2020 Oct 7;11(1):5038.
|
||
doi: 10.1038/s41467-020-18752-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33028830" target="_blank">33028830</a><a href="/pmc/articles/PMC7541486" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29278548">The current place of epilepsy surgery.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Engel J Jr</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Neurol</span>
|
||
2018 Apr;31(2):192-197.
|
||
doi: 10.1097/WCO.0000000000000528.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29278548" target="_blank">29278548</a><a href="/pmc/articles/PMC6009838" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23027091">Mesial temporal lobe epilepsy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tatum WO 4th</span><br />
|
||
<span class="medgenPMjournal">J Clin Neurophysiol</span>
|
||
2012 Oct;29(5):356-65.
|
||
doi: 10.1097/WNP.0b013e31826b3ab7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23027091" target="_blank">23027091</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Epilepsy%2C%20familial%20temporal%20lobe%2C%201%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1583)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37802038">Human pallial MGE-type GABAergic interneuron cell therapy for chronic focal epilepsy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bershteyn M,
|
||
Bröer S,
|
||
Parekh M,
|
||
Maury Y,
|
||
Havlicek S,
|
||
Kriks S,
|
||
Fuentealba L,
|
||
Lee S,
|
||
Zhou R,
|
||
Subramanyam G,
|
||
Sezan M,
|
||
Sevilla ES,
|
||
Blankenberger W,
|
||
Spatazza J,
|
||
Zhou L,
|
||
Nethercott H,
|
||
Traver D,
|
||
Hampel P,
|
||
Kim H,
|
||
Watson M,
|
||
Salter N,
|
||
Nesterova A,
|
||
Au W,
|
||
Kriegstein A,
|
||
Alvarez-Buylla A,
|
||
Rubenstein J,
|
||
Banik G,
|
||
Bulfone A,
|
||
Priest C,
|
||
Nicholas CR</span><br />
|
||
<span class="medgenPMjournal">Cell Stem Cell</span>
|
||
2023 Oct 5;30(10):1331-1350.e11.
|
||
doi: 10.1016/j.stem.2023.08.013.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37802038" target="_blank">37802038</a><a href="/pmc/articles/PMC10993865" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37603261">New GABA-Targeting Therapies for the Treatment of Seizures and Epilepsy: II. Treatments in Clinical Development.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Perucca E,
|
||
White HS,
|
||
Bialer M</span><br />
|
||
<span class="medgenPMjournal">CNS Drugs</span>
|
||
2023 Sep;37(9):781-795.
|
||
Epub 2023 Aug 21
|
||
doi: 10.1007/s40263-023-01025-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37603261" target="_blank">37603261</a><a href="/pmc/articles/PMC10501930" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29278548">The current place of epilepsy surgery.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Engel J Jr</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Neurol</span>
|
||
2018 Apr;31(2):192-197.
|
||
doi: 10.1097/WCO.0000000000000528.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29278548" target="_blank">29278548</a><a href="/pmc/articles/PMC6009838" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25703438">Invasive EEG explorations.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Taussig D,
|
||
Montavont A,
|
||
Isnard J</span><br />
|
||
<span class="medgenPMjournal">Neurophysiol Clin</span>
|
||
2015 Mar;45(1):113-9.
|
||
Epub 2015 Jan 15
|
||
doi: 10.1016/j.neucli.2014.11.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25703438" target="_blank">25703438</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9693227">Pilomotor seizures.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yu H,
|
||
Yen D,
|
||
Yiu C,
|
||
Chung W,
|
||
Lirng J,
|
||
Su M</span><br />
|
||
<span class="medgenPMjournal">Eur Neurol</span>
|
||
1998 Jul;40(1):19-21.
|
||
doi: 10.1159/000007950.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9693227" target="_blank">9693227</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Epilepsy%2C%20familial%20temporal%20lobe%2C%201%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (792)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39294238">Machine learning algorithm for predicting seizure control after temporal lobe resection using peri-ictal electroencephalography.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sheikh SR,
|
||
McKee ZA,
|
||
Ghosn S,
|
||
Jeong KS,
|
||
Kattan M,
|
||
Burgess RC,
|
||
Jehi L,
|
||
Saab CY</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2024 Sep 18;14(1):21771.
|
||
doi: 10.1038/s41598-024-72249-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39294238" target="_blank">39294238</a><a href="/pmc/articles/PMC11410994" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23027091">Mesial temporal lobe epilepsy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tatum WO 4th</span><br />
|
||
<span class="medgenPMjournal">J Clin Neurophysiol</span>
|
||
2012 Oct;29(5):356-65.
|
||
doi: 10.1097/WNP.0b013e31826b3ab7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23027091" target="_blank">23027091</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10570755">Temporal lobe epilepsy, temporal lobectomy, and major depression.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Altshuler L,
|
||
Rausch R,
|
||
Delrahim S,
|
||
Kay J,
|
||
Crandall P</span><br />
|
||
<span class="medgenPMjournal">J Neuropsychiatry Clin Neurosci</span>
|
||
1999 Fall;11(4):436-43.
|
||
doi: 10.1176/jnp.11.4.436.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10570755" target="_blank">10570755</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/5552161">Clinical course and prognosis of temporal lobe epilepsy. A survey of 666 patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Currie S,
|
||
Heathfield KW,
|
||
Henson RA,
|
||
Scott DF</span><br />
|
||
<span class="medgenPMjournal">Brain</span>
|
||
1971;94(1):173-90.
|
||
doi: 10.1093/brain/94.1.173.
|
||
<span class="bold">PMID: </span><a href="/pubmed/5552161" target="_blank">5552161</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/4179361">Temporal-lob epilepsy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMjournal">Lancet</span>
|
||
1969 Feb 15;1(7590):356-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/4179361" target="_blank">4179361</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Epilepsy%2C%20familial%20temporal%20lobe%2C%201%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1128)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37597255">Familial Mesial Temporal Lobe Epilepsy: Clinical Spectrum and Genetic Evidence for a Polygenic Architecture.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Harris RV,
|
||
Oliver KL,
|
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Perucca P,
|
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Striano P,
|
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Labate A,
|
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Riva A,
|
||
Grinton BE,
|
||
Reid J,
|
||
Hutton J,
|
||
Todaro M,
|
||
O'Brien TJ,
|
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Kwan P,
|
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Sadleir LG,
|
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Mullen SA,
|
||
Dazzo E,
|
||
Crompton DE,
|
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Scheffer IE,
|
||
Bahlo M,
|
||
Nobile C,
|
||
Gambardella A,
|
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Berkovic SF</span><br />
|
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<span class="medgenPMjournal">Ann Neurol</span>
|
||
2023 Nov;94(5):825-835.
|
||
Epub 2023 Aug 31
|
||
doi: 10.1002/ana.26765.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37597255" target="_blank">37597255</a><a href="/pmc/articles/PMC10952415" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33028830">Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pfisterer U,
|
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Petukhov V,
|
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Demharter S,
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Meichsner J,
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Thompson JJ,
|
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Batiuk MY,
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Asenjo-Martinez A,
|
||
Vasistha NA,
|
||
Thakur A,
|
||
Mikkelsen J,
|
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Adorjan I,
|
||
Pinborg LH,
|
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Pers TH,
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von Engelhardt J,
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Kharchenko PV,
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Khodosevich K</span><br />
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<span class="medgenPMjournal">Nat Commun</span>
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2020 Oct 7;11(1):5038.
|
||
doi: 10.1038/s41467-020-18752-7.
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||
<span class="bold">PMID: </span><a href="/pubmed/33028830" target="_blank">33028830</a><a href="/pmc/articles/PMC7541486" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23027091">Mesial temporal lobe epilepsy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tatum WO 4th</span><br />
|
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<span class="medgenPMjournal">J Clin Neurophysiol</span>
|
||
2012 Oct;29(5):356-65.
|
||
doi: 10.1097/WNP.0b013e31826b3ab7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23027091" target="_blank">23027091</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10570755">Temporal lobe epilepsy, temporal lobectomy, and major depression.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Altshuler L,
|
||
Rausch R,
|
||
Delrahim S,
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Kay J,
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Crandall P</span><br />
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<span class="medgenPMjournal">J Neuropsychiatry Clin Neurosci</span>
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1999 Fall;11(4):436-43.
|
||
doi: 10.1176/jnp.11.4.436.
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||
<span class="bold">PMID: </span><a href="/pubmed/10570755" target="_blank">10570755</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7845562">Planum temporale asymmetry and language dominance.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Foundas AL,
|
||
Leonard CM,
|
||
Gilmore R,
|
||
Fennell E,
|
||
Heilman KM</span><br />
|
||
<span class="medgenPMjournal">Neuropsychologia</span>
|
||
1994 Oct;32(10):1225-31.
|
||
doi: 10.1016/0028-3932(94)90104-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7845562" target="_blank">7845562</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Epilepsy%2C%20familial%20temporal%20lobe%2C%201%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1547)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/37611927">Postoperative seizure and memory outcome of temporal lobe epilepsy with hippocampal sclerosis: A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Li Y,
|
||
Liu P,
|
||
Lin Q,
|
||
Zhou D,
|
||
An D</span><br />
|
||
<span class="medgenPMjournal">Epilepsia</span>
|
||
2023 Nov;64(11):2845-2860.
|
||
Epub 2023 Sep 30
|
||
doi: 10.1111/epi.17757.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37611927" target="_blank">37611927</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35249578">Social Cognition in Temporal and Frontal Lobe Epilepsy: Systematic Review, Meta-analysis, and Clinical Recommendations.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ziaei M,
|
||
Arnold C,
|
||
Thompson K,
|
||
Reutens DC</span><br />
|
||
<span class="medgenPMjournal">J Int Neuropsychol Soc</span>
|
||
2023 Feb;29(2):205-229.
|
||
Epub 2022 Mar 7
|
||
doi: 10.1017/S1355617722000066.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35249578" target="_blank">35249578</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36041364">Multiple hippocampal transection for mesial temporal lobe epilepsy: A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Abramov I,
|
||
Jubran JH,
|
||
Houlihan LM,
|
||
Park MT,
|
||
Howshar JT,
|
||
Farhadi DS,
|
||
Loymak T,
|
||
Cole TS,
|
||
Pitskhelauri D,
|
||
Preul MC</span><br />
|
||
<span class="medgenPMjournal">Seizure</span>
|
||
2022 Oct;101:162-176.
|
||
Epub 2022 Aug 23
|
||
doi: 10.1016/j.seizure.2022.08.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36041364" target="_blank">36041364</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35905516">Depression and suicide after temporal lobe epilepsy surgery: A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hue CD,
|
||
Couper RG,
|
||
Antaya TC,
|
||
Herrera M,
|
||
Parra J,
|
||
Burneo JG</span><br />
|
||
<span class="medgenPMjournal">Epilepsy Behav</span>
|
||
2022 Sep;134:108853.
|
||
Epub 2022 Jul 26
|
||
doi: 10.1016/j.yebeh.2022.108853.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35905516" target="_blank">35905516</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30167878">Gluten sensitivity and epilepsy: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Julian T,
|
||
Hadjivassiliou M,
|
||
Zis P</span><br />
|
||
<span class="medgenPMjournal">J Neurol</span>
|
||
2019 Jul;266(7):1557-1565.
|
||
Epub 2018 Aug 23
|
||
doi: 10.1007/s00415-018-9025-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30167878" target="_blank">30167878</a><a href="/pmc/articles/PMC6586915" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Epilepsy%2C%20familial%20temporal%20lobe%2C%201%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (50)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
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|
||
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|
||
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|
||
|
||
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|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
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|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C4551957%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (20)</a></li>
|
||
<li><a href="/gtr/tests?term=C4551957%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C4551957%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (27)</a></li>
|
||
<li><a href="/gtr/tests?term=C4551957%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (2)</a></li>
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<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C4551957%5bDISCUI%5d" target="_blank">See all (30)</a></total></li>
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<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=600512" target="_blank">OMIM</a></li><li><a href="https://clinicaltrials.gov/search?cond=Epilepsy,%20familial%20temporal%20lobe,%201" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(epilepsy%2C%20familial%20temporal%20lobe%2C%201)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Molecular_resources">Molecular resources</h1><a sid="115" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=600514%20604619%20607129" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=5649[geneid]" target="_blank">View RELN variations in ClinVar</a></li><li><a href="/clinvar/?term=9211[geneid]" target="_blank">View LGI1 variations in ClinVar</a></li><li><a href="/clinvar/?term=64780[geneid]" target="_blank">View MICAL1 variations in ClinVar</a></li><li><a href="/nuccore/226530028,226823320" target="_blank">RefSeqGene</a></li><li><a href="https://catalog.coriell.org/Search?q=600512" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="https://www.malacards.org/card/epilepsy_familial_temporal_lobe_1" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Epilepsy,%20familial%20temporal%20lobe,%201" target="_blank">MedlinePlus</a></li><li><a href="https://medlineplus.gov/genetics/condition/autosomal-dominant-epilepsy-with-auditory-features" target="_blank">MedlinePlusGenetics (GHR)</a></li></ul></div>
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<h3>Reviews</h3>
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<ul>
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<li>
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<a href="/pubmed/20301709" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=3" target="_blank"><span class="gene_reviews">GeneReviews</span></a>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/clinical?term=Epilepsy,%20familial%20temporal%20lobe,%201" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=3" target="_blank">PubMed Clinical Queries</a>
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</li>
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||
<li>
|
||
<a href="/pubmed?term=Epilepsy,%20familial%20temporal%20lobe,%201%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=3&linkpostotal=3" target="_blank">Reviews in PubMed</a>
|
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</li>
|
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||
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||
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<div class="portlet brieflink">
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<div class="portlet_head">
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<h3>Related information</h3>
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</div>
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<div class="portlet_content DiscoveryDbLinks">
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<ul>
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||
<li class="brieflinkpopper">
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||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=1643229" ref="log$=recordlinks">ClinVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gene?LinkName=medgen_gene_diseases&from_uid=1643229" ref="log$=recordlinks">Gene</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in NCBI Gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
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