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<meta name="keywords" content="C4551685, diaphragmatic paralysis, finding, paralysed diaphragm, paralysis of diaphragm, paralyzed diaphragm, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="The presence of a paralyzed diaphragm." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Diaphragmatic paralysis (Concept Id: C4551685)
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<!--
UID=1632032
ConceptID=C4551685
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Diaphragmatic paralysis</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1632032</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4551685</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Paralysed diaphragm; Paralysis of diaphragm; Paralyzed diaphragm</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Paralysis of diaphragm (64228003); Diaphragmatic paralysis (64228003)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0006597">HP:0006597</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">The presence of a paralyzed diaphragm. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Diaphragmatic paralysis</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/1763488" ref="tree=MeSH" title="MedGen record for Abnormality of the musculoskeletal system">Abnormality of the musculoskeletal system</a></span><ul><li><span class="TLline"><a href="/medgen/867380" ref="tree=MeSH" title="MedGen record for Abnormality of the musculature">Abnormality of the musculature</a></span><ul><li><span class="TLline"><a href="/medgen/868777" ref="tree=MeSH" title="MedGen record for Abnormal muscle physiology">Abnormal muscle physiology</a></span><ul><li><span class="TLline"><a href="/medgen/57735" ref="tree=MeSH" title="MedGen record for Muscle weakness">Muscle weakness</a></span><ul><li><span class="TLline"><a href="/medgen/101067" ref="tree=MeSH" title="MedGen record for Diaphragmatic weakness">Diaphragmatic weakness</a></span><ul><li><span class="matched_ds">Diaphragmatic paralysis</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_5340"><div><strong>Glycogen storage disease, type II</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>5340</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0017921</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Pompe disease is classified by age of onset, organ involvement, severity, and rate of progression. Infantile-onset Pompe disease (IOPD; individuals with onset before age 12 months with cardiomyopathy) may be apparent in utero but more typically onset is at the median age of four months with hypotonia, generalized muscle weakness, feeding difficulties, failure to thrive, respiratory distress, and hypertrophic cardiomyopathy. Without treatment by enzyme replacement therapy (ERT), IOPD commonly results in death by age two years from progressive left ventricular outflow obstruction and respiratory insufficiency. Late-onset Pompe disease (LOPD; including: (a) individuals with onset before age 12 months without cardiomyopathy; and (b) all individuals with onset after age 12 months) is characterized by proximal muscle weakness and respiratory insufficiency; clinically significant cardiac involvement is uncommon.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/5340">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_388083"><div><strong>Autosomal recessive distal spinal muscular atrophy 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>388083</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1858517</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Autosomal recessive distal hereditary motor neuronopathy-1 (HMNR1) is characterized by distal and proximal muscle weakness and diaphragmatic palsy that leads to respiratory distress. Without intervention, most infants with the severe form of the disease die before 2 years of age. Affected individuals present in infancy with inspiratory stridor, weak cry, recurrent bronchopneumonia, and swallowing difficulties. The disorder is caused by distal and progressive motor neuronopathy resulting in muscle weakness (summary by Perego et al., 2020).&#13; Genetic Heterogeneity of Autosomal Recessive Distal Hereditary Motor Neuronopathy&#13; See also HMNR2 (605726), caused by mutation in the SIGMAR1 gene (601978); HMNR3 (607088) (encompassing Harding HMN types III and IV), which maps to chromosome 11q13; HMNR4 (611067), caused by mutation in the PLEKHG5 gene (611101); HMNR5 (614881), caused by mutation in the DNAJB2 gene (604139); HMNR6 (620011), caused by mutation in the REEP1 gene (609139); HMNR7 (619216), caused by mutation in the VWA1 gene (611901); HMNR8 (618912), caused by mutation in the SORD gene (182500); HMNR9 (620402), caused by mutation in the COQ7 gene (601683); HMNR10 (620542), caused by mutation in the VRK1 gene (602168); and HMNR11 (620854), caused by mutation in the RTN2 gene (603183).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/388083">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_414119"><div><strong>Myofibrillar myopathy 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>414119</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C2751831</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Myofibrillar myopathy-6 (MFM6) is an autosomal dominant severe neuromuscular disorder characterized by onset in the first decade of progressive generalized and proximal muscle weakness, respiratory insufficiency, cardiomyopathy, and skeletal deformities related to muscle weakness. Most patients also have a motor or sensorimotor axonal peripheral neuropathy. Muscle biopsy shows fiber-type grouping, disruption of the Z lines, rimmed vacuoles, and filamentous inclusions, consistent with a myofibrillar myopathy. The disorder may cause severe disability by the second decade, leading to cardiac transplant, ventilation, and/or loss of ambulation (summary by Jaffer et al., 2012).&#13; For a phenotypic description and a discussion of genetic heterogeneity of myofibrillar myopathy (MFM), see MFM1 (601419).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/414119">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_482309"><div><strong>MEGF10-related myopathy</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>482309</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3280679</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Congenital myopathy-10A (CMYO10A) is a severe autosomal recessive skeletal muscle disorder characterized by generalized hypotonia, respiratory insufficiency, and poor feeding apparent from birth. Decreased fetal movements may be observed. More variable features include high-arched palate, distal joint contractures, foot deformities, scoliosis, areflexia, and dysphagia. Many patients show eventration of the diaphragm. Affected individuals become ventilator-dependent in the first months or years of life and never achieve walking; many die in childhood (Logan et al., 2011).&#13; Patients with more damaging mutations in the MEGF10 gene, including nonsense or frameshift null mutations, show the more severe phenotype (CMYO10A), whereas those with missense mutations affecting conserved cysteine residues in the EGF-like domain show the less severe phenotype with later onset of respiratory failure and minicores on muscle biopsy (CMYO10B) (Croci et al., 2022).&#13; For a discussion of genetic heterogeneity of congenital myopathy, see CMYO1A (117000).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/482309">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1823974"><div><strong>Spinal muscular atrophy, distal, autosomal recessive, 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1823974</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5774201</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Autosomal recessive distal hereditary motor neuronopathy-6 (HMNR6) is a neuromuscular disorder characterized by onset of distal muscle weakness in early infancy. Affected individuals often present at birth with distal joint contractures or foot deformities and show delayed motor development, often with inability to walk or frequent falls. Hypo- or hyperreflexia may be observed; limb muscle atrophy may also be present. Patients often show respiratory distress or diaphragmatic palsy. Electrophysiologic studies are consistent with a peripheral motor neuropathy without sensory involvement (Maroofian et al., 2019).&#13; For a discussion of genetic heterogeneity of autosomal recessive distal HMN, see HMNR1 (604320).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1823974">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_388083" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal recessive distal spinal muscular atrophy 1</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_5340" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Glycogen storage disease, type II</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_482309" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">MEGF10-related myopathy</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_414119" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Myofibrillar myopathy 6</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1823974" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Spinal muscular atrophy, distal, autosomal recessive, 6</a></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/34669841">Measurements of respiratory muscle function as diagnostic criteria for diaphragmatic paralysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Caleffi-Pereira M,
Albuquerque ALP</span><br />
<span class="medgenPMjournal">J Bras Pneumol</span>
2021 Oct 15;47(5):e20210310.
doi: 10.36416/1806-3756/e20210310.
<span class="bold">PMID: </span><a href="/pubmed/34669841" target="_blank">34669841</a><a href="/pmc/articles/PMC9013532" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/8031569">Diaphragmatic paralysis after cardiac surgery in infants: prolonged medical management or surgical plication?</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Jekel L,
Benatar A,
Woolley S,
van de Wal HJ</span><br />
<span class="medgenPMjournal">Eur J Cardiothorac Surg</span>
1994;8(4):225.
doi: 10.1016/1010-7940(94)90121-x.
<span class="bold">PMID: </span><a href="/pubmed/8031569" target="_blank">8031569</a></div>
<div class="nl"><a target="_blank" href="/pubmed/20286975">Pneumoperitoneum with diaphragmatic paralysis in the treatment of pulmonary tuberculosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">GILMORE DJ</span><br />
<span class="medgenPMjournal">Dis Chest</span>
1947 Mar;13(2):153-61.
doi: 10.1378/chest.13.2.153.
<span class="bold">PMID: </span><a href="/pubmed/20286975" target="_blank">20286975</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22diaphragmatic%20paralysis%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (8)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/35747986">Diaphragmatic paralysis in a neonate with circumferential skin creases Kunze type.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chun Fang G,
Kaiwei D,
Lingkong Z,
Xuwei T</span><br />
<span class="medgenPMjournal">Mol Genet Genomic Med</span>
2022 Sep;10(9):e2003.
Epub 2022 Jun 23
doi: 10.1002/mgg3.2003.
<span class="bold">PMID: </span><a href="/pubmed/35747986" target="_blank">35747986</a><a href="/pmc/articles/PMC9482402" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35414108">Effects of double vs triple injection on block dynamics for ultrasound-guided intertruncal approach to the supraclavicular brachial plexus block in patients undergoing upper limb arteriovenous access surgery: study protocol for a double-blinded, randomized controlled trial.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Luo Q,
Liu H,
Deng L,
Nong L,
Li H,
Cai Y,
Zheng J,
Shu H,
Yao W,
Zhang J</span><br />
<span class="medgenPMjournal">Trials</span>
2022 Apr 12;23(1):295.
doi: 10.1186/s13063-022-06260-6.
<span class="bold">PMID: </span><a href="/pubmed/35414108" target="_blank">35414108</a><a href="/pmc/articles/PMC9006596" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33054689">Prospective analysis of a surgical algorithm to achieve ventilator weaning in cervical tetraplegia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kaufman MR,
Bauer T,
Campbell S,
Rossi K,
Elkwood A,
Jarrahy R</span><br />
<span class="medgenPMjournal">J Spinal Cord Med</span>
2022 Jul;45(4):531-535.
Epub 2020 Oct 15
doi: 10.1080/10790268.2020.1829417.
<span class="bold">PMID: </span><a href="/pubmed/33054689" target="_blank">33054689</a><a href="/pmc/articles/PMC9246221" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/12556936">Fibrin glue for persistent pneumothorax in neonates.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sarkar S,
Hussain N,
Herson V</span><br />
<span class="medgenPMjournal">J Perinatol</span>
2003 Jan;23(1):82-4.
doi: 10.1038/sj.jp.7210852.
<span class="bold">PMID: </span><a href="/pubmed/12556936" target="_blank">12556936</a></div>
<div class="nl"><a target="_blank" href="/pubmed/7626876">Warm heart surgery eliminates diaphragmatic paralysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Maccherini M,
Davoli G,
Sani G,
Rossi P,
Giani S,
Lisi G,
Mazzesi G,
Toscano M</span><br />
<span class="medgenPMjournal">J Card Surg</span>
1995 May;10(3):257-61.
doi: 10.1111/j.1540-8191.1995.tb00606.x.
<span class="bold">PMID: </span><a href="/pubmed/7626876" target="_blank">7626876</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Diaphragmatic%20paralysis%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (152)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/36089515">Diagnosis of diaphragmatic paralysis by ultrasound after cardiac surgery.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Santos Peral A,
Gómez Carranza A,
Vicho Pereira R</span><br />
<span class="medgenPMjournal">Med Intensiva (Engl Ed)</span>
2023 Feb;47(2):120-121.
Epub 2022 Sep 8
doi: 10.1016/j.medine.2022.07.017.
<span class="bold">PMID: </span><a href="/pubmed/36089515" target="_blank">36089515</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34510092">Electromyography in Congenital Zika Syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gouveia de Melo ACM,
van der Linden V,
Serpa SC,
Rolim Filho EL,
Lins OG</span><br />
<span class="medgenPMjournal">J Clin Neurophysiol</span>
2023 May 1;40(4):350-354.
Epub 2021 Sep 6
doi: 10.1097/WNP.0000000000000893.
<span class="bold">PMID: </span><a href="/pubmed/34510092" target="_blank">34510092</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22411950">Imaging of the diaphragm: anatomy and function.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Nason LK,
Walker CM,
McNeeley MF,
Burivong W,
Fligner CL,
Godwin JD</span><br />
<span class="medgenPMjournal">Radiographics</span>
2012 Mar-Apr;32(2):E51-70.
doi: 10.1148/rg.322115127.
<span class="bold">PMID: </span><a href="/pubmed/22411950" target="_blank">22411950</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19965299">Thoracic complications and emergencies in oncologic patients.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Quint LE</span><br />
<span class="medgenPMjournal">Cancer Imaging</span>
2009 Oct 2;9 Spec No A(Special issue A):S75-82.
doi: 10.1102/1470-7330.2009.9031.
<span class="bold">PMID: </span><a href="/pubmed/19965299" target="_blank">19965299</a><a href="/pmc/articles/PMC2797469" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19452391">Diaphragm paralysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Qureshi A</span><br />
<span class="medgenPMjournal">Semin Respir Crit Care Med</span>
2009 Jun;30(3):315-20.
Epub 2009 May 18
doi: 10.1055/s-0029-1222445.
<span class="bold">PMID: </span><a href="/pubmed/19452391" target="_blank">19452391</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Diaphragmatic%20paralysis%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (228)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/37970880">Early-Onset Respiratory Muscle Paralysis in Crotalic Envenomation: A Case Study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Almeida JS,
Possas FC,
de Andrade Filho A,
Sauzen SO,
Sugino RG</span><br />
<span class="medgenPMjournal">Rev Soc Bras Med Trop</span>
2023;56:e03742023.
Epub 2023 Nov 10
doi: 10.1590/0037-8682-0374-2023.
<span class="bold">PMID: </span><a href="/pubmed/37970880" target="_blank">37970880</a><a href="/pmc/articles/PMC10637731" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34510092">Electromyography in Congenital Zika Syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gouveia de Melo ACM,
van der Linden V,
Serpa SC,
Rolim Filho EL,
Lins OG</span><br />
<span class="medgenPMjournal">J Clin Neurophysiol</span>
2023 May 1;40(4):350-354.
Epub 2021 Sep 6
doi: 10.1097/WNP.0000000000000893.
<span class="bold">PMID: </span><a href="/pubmed/34510092" target="_blank">34510092</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36178083">Spontaneous recovery from diaphragmatic paralysis after liver transplantation.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hosokawa T,
Tanami Y,
Ihara Y,
Mizuta K,
Oguma E</span><br />
<span class="medgenPMjournal">Pediatr Int</span>
2022 Jan;64(1):e15266.
doi: 10.1111/ped.15266.
<span class="bold">PMID: </span><a href="/pubmed/36178083" target="_blank">36178083</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31412424">Hepatobiliary and Pancreatic: Diaphragmatic paralysis after transarterial chemoembolization of hepatocellular carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pandya K,
Liu K,
Strasser SI</span><br />
<span class="medgenPMjournal">J Gastroenterol Hepatol</span>
2020 Feb;35(2):181.
Epub 2019 Sep 12
doi: 10.1111/jgh.14834.
<span class="bold">PMID: </span><a href="/pubmed/31412424" target="_blank">31412424</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30862399">Unilateral diaphragmatic paralysis after laparoscopic cholecystectomy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Díez Castillo E,
Telletxea Benguria S,
Intxaurraga Fernández K,
Esnaola Iriarte B</span><br />
<span class="medgenPMjournal">Rev Esp Anestesiol Reanim (Engl Ed)</span>
2019 Jun-Jul;66(6):342-345.
Epub 2019 Mar 9
doi: 10.1016/j.redar.2019.01.006.
<span class="bold">PMID: </span><a href="/pubmed/30862399" target="_blank">30862399</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Diaphragmatic%20paralysis%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (163)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/31883769">Tracheal, Lung, and Diaphragmatic Applications of M-Mode Ultrasonography in Anesthesiology and Critical Care.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Prada G,
Vieillard-Baron A,
Martin AK,
Hernandez A,
Mookadam F,
Ramakrishna H,
Diaz-Gomez JL</span><br />
<span class="medgenPMjournal">J Cardiothorac Vasc Anesth</span>
2021 Jan;35(1):310-322.
Epub 2019 Dec 5
doi: 10.1053/j.jvca.2019.11.051.
<span class="bold">PMID: </span><a href="/pubmed/31883769" target="_blank">31883769</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30269091">Neuromyelitis optica with unilateral diaphragmatic paralysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bennji S,
Sagar D,
Brey N,
Koegelenberg C</span><br />
<span class="medgenPMjournal">BMJ Case Rep</span>
2018 Sep 28;2018
doi: 10.1136/bcr-2018-225984.
<span class="bold">PMID: </span><a href="/pubmed/30269091" target="_blank">30269091</a><a href="/pmc/articles/PMC6169650" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24469968">Diaphragmatic paralysis associated with herpes zoster and HIV-tuberculosis co-infection.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Benabdellah A,
Souhil T,
Farouk ZO</span><br />
<span class="medgenPMjournal">Int J STD AIDS</span>
2014 Aug;25(9):686-8.
Epub 2014 Jan 27
doi: 10.1177/0956462413518507.
<span class="bold">PMID: </span><a href="/pubmed/24469968" target="_blank">24469968</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19452391">Diaphragm paralysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Qureshi A</span><br />
<span class="medgenPMjournal">Semin Respir Crit Care Med</span>
2009 Jun;30(3):315-20.
Epub 2009 May 18
doi: 10.1055/s-0029-1222445.
<span class="bold">PMID: </span><a href="/pubmed/19452391" target="_blank">19452391</a></div>
<div class="nl"><a target="_blank" href="/pubmed/12556936">Fibrin glue for persistent pneumothorax in neonates.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sarkar S,
Hussain N,
Herson V</span><br />
<span class="medgenPMjournal">J Perinatol</span>
2003 Jan;23(1):82-4.
doi: 10.1038/sj.jp.7210852.
<span class="bold">PMID: </span><a href="/pubmed/12556936" target="_blank">12556936</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Diaphragmatic%20paralysis%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (114)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/35918788">A randomised controlled trial in patients undergoing arthroscopic shoulder surgery comparing interscalene block with either 10ml or 20ml levobupivacaine 0.25.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Oliver-Fornies P,
Gomez Gomez R,
Ortega Lahuerta JP,
Carbonel Bueno I,
Gonzalo Pellicer I,
Ripalda Marin J,
Orellana Melgar CE,
Fajardo Perez M</span><br />
<span class="medgenPMjournal">Anaesthesia</span>
2022 Oct;77(10):1106-1112.
Epub 2022 Aug 2
doi: 10.1111/anae.15822.
<span class="bold">PMID: </span><a href="/pubmed/35918788" target="_blank">35918788</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33054689">Prospective analysis of a surgical algorithm to achieve ventilator weaning in cervical tetraplegia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kaufman MR,
Bauer T,
Campbell S,
Rossi K,
Elkwood A,
Jarrahy R</span><br />
<span class="medgenPMjournal">J Spinal Cord Med</span>
2022 Jul;45(4):531-535.
Epub 2020 Oct 15
doi: 10.1080/10790268.2020.1829417.
<span class="bold">PMID: </span><a href="/pubmed/33054689" target="_blank">33054689</a><a href="/pmc/articles/PMC9246221" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31883769">Tracheal, Lung, and Diaphragmatic Applications of M-Mode Ultrasonography in Anesthesiology and Critical Care.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Prada G,
Vieillard-Baron A,
Martin AK,
Hernandez A,
Mookadam F,
Ramakrishna H,
Diaz-Gomez JL</span><br />
<span class="medgenPMjournal">J Cardiothorac Vasc Anesth</span>
2021 Jan;35(1):310-322.
Epub 2019 Dec 5
doi: 10.1053/j.jvca.2019.11.051.
<span class="bold">PMID: </span><a href="/pubmed/31883769" target="_blank">31883769</a></div>
<div class="nl"><a target="_blank" href="/pubmed/10204776">Neuralgic amyotrophy with phrenic nerve involvement.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lahrmann H,
Grisold W,
Authier FJ,
Zifko UA</span><br />
<span class="medgenPMjournal">Muscle Nerve</span>
1999 Apr;22(4):437-42.
doi: 10.1002/(sici)1097-4598(199904)22:4&lt;437::aid-mus2&gt;3.0.co;2-f.
<span class="bold">PMID: </span><a href="/pubmed/10204776" target="_blank">10204776</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21005383">Diaphragmatic paralysis and pneumoperitoneum; therapeutic observations in white patients.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">CROW HE,
WHELCHEL FC</span><br />
<span class="medgenPMjournal">Am Rev Tuberc</span>
1945 Nov;52:367-79.
doi: 10.1164/art.1945.52.5.367.
<span class="bold">PMID: </span><a href="/pubmed/21005383" target="_blank">21005383</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Diaphragmatic%20paralysis%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (104)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_104">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/39639468">Diaphragm pacing compared with mechanical ventilation in patients with chronic respiratory failure caused by diaphragmatic dysfunction: a systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Arango-Cortes ML,
Giraldo-Cadavid LF,
Latorre Quintana M,
Forero-Cubides JD,
Gonzalez-Bermejo J</span><br />
<span class="medgenPMjournal">Expert Rev Respir Med</span>
2024 Dec;18(12):1101-1111.
Epub 2024 Dec 5
doi: 10.1080/17476348.2024.2421846.
<span class="bold">PMID: </span><a href="/pubmed/39639468" target="_blank">39639468</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36089276">Phrenic Nerve Dysfunction Secondary to Cervical Neuroforaminal Stenosis: A Literature Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yekzaman BR,
Minchew HM,
Alvarado A,
Ohiorhenuan I</span><br />
<span class="medgenPMjournal">World Neurosurg</span>
2022 Nov;167:74-77.
Epub 2022 Sep 8
doi: 10.1016/j.wneu.2022.09.009.
<span class="bold">PMID: </span><a href="/pubmed/36089276" target="_blank">36089276</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34294596">Complications associated with three brachial plexus blocking techniques: Systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Casas-Arroyave FD,
Ramírez-Mendoza E,
Ocampo-Agudelo AF</span><br />
<span class="medgenPMjournal">Rev Esp Anestesiol Reanim (Engl Ed)</span>
2021 Aug-Sep;68(7):392-407.
Epub 2021 Jul 20
doi: 10.1016/j.redare.2020.10.003.
<span class="bold">PMID: </span><a href="/pubmed/34294596" target="_blank">34294596</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30300178">Regional Analgesia Added to General Anesthesia Compared With General Anesthesia Plus Systemic Analgesia for Cardiac Surgery in Children: A Systematic Review and Meta-analysis of Randomized Clinical Trials.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Monahan A,
Guay J,
Hajduk J,
Suresh S</span><br />
<span class="medgenPMjournal">Anesth Analg</span>
2019 Jan;128(1):130-136.
doi: 10.1213/ANE.0000000000003831.
<span class="bold">PMID: </span><a href="/pubmed/30300178" target="_blank">30300178</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Diaphragmatic%20paralysis%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4)</a></div></div>
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