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<meta name="keywords" content="C0702166, acne, acne (disease), acne varioliformis, acne vulgaris, breaking out, disease or syndrome, frontalis acne, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A skin condition in which there is an increase in sebum secretion by the pilosebaceous apparatus associated with open comedones (blackheads), closed comedones (whiteheads), and pustular nodules (papules, pustules, and cysts)." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
|
||
UID=152379
|
||
ConceptID=C0702166
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Acne</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>152379</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0702166</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>acne; acne (disease); acne varioliformis; acne vulgaris; Breaking out; frontalis acne</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Acne (11381005)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0001061">HP:0001061</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0011438" target="_blank">MONDO:0011438</a></td></tr>
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||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_content ln">A skin condition in which there is an increase in sebum secretion by the pilosebaceous apparatus associated with open comedones (blackheads), closed comedones (whiteheads), and pustular nodules (papules, pustules, and cysts). [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0702166[DISCUI]&test_type=Clinical" ref="ncbi_uid=152379">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Acne</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/867388" ref="tree=MeSH" title="MedGen record for Abnormality of the immune system">Abnormality of the immune system</a></span><ul><li><span class="TLline"><a href="/medgen/869194" ref="tree=MeSH" title="MedGen record for Abnormality of immune system physiology">Abnormality of immune system physiology</a></span><ul><li><span class="TLline"><a href="/medgen/868411" ref="tree=MeSH" title="MedGen record for Abnormal inflammatory response">Abnormal inflammatory response</a></span><ul><li><span class="TLline"><a href="/medgen/868409" ref="tree=MeSH" title="MedGen record for Increased inflammatory response">Increased inflammatory response</a></span><ul><li><span class="TLline"><a href="/medgen/849741" ref="tree=MeSH" title="MedGen record for Inflammatory abnormality of the skin">Inflammatory abnormality of the skin</a></span><ul><li><span class="matched_ds">Acne</span><ul><li><span class="TLline"><a href="/medgen/57993" ref="tree=MeSH" title="MedGen record for Acne inversa">Acne inversa</a></span></li><li><span class="TLline"><a href="/medgen/590448" ref="tree=MeSH" title="MedGen record for Comedonal acne">Comedonal acne</a></span></li><li><span class="TLline"><a href="/medgen/507614" ref="tree=MeSH" title="MedGen record for Cystic acne">Cystic acne</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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||
</div>
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||
<div class="portlet mgSection" id="ID_112">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_7858"><div><strong>Acrocephalosyndactyly type I</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>7858</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0001193</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Apert syndrome is characterized by the presence of multisuture craniosynostosis, midface retrusion, and syndactyly of the hands with fusion of the second through fourth nails. Almost all affected individuals have coronal craniosynostosis, and a majority also have involvement of the sagittal and lambdoid sutures. The midface in Apert syndrome is underdeveloped as well as retruded; a subset of affected individuals have cleft palate. The hand in Apert syndrome always includes fusion of the middle three digits; the thumb and fifth finger are sometimes also involved. Feeding issues, dental abnormalities, hearing loss, hyperhidrosis, and progressive synostosis of multiple bones (skull, hands, feet, carpus, tarsus, and cervical vertebrae) are also common. Multilevel airway obstruction may be present and can be due to narrowing of the nasal passages, tongue-based airway obstruction, and/or tracheal anomalies. Nonprogressive ventriculomegaly is present in a majority of individuals, with a small subset having true hydrocephalus. Most individuals with Apert syndrome have normal intelligence or mild intellectual disability; moderate-to-severe intellectual disability has been reported in some individuals. A minority of affected individuals have structural cardiac abnormalities, true gastrointestinal malformations, and anomalies of the genitourinary tract.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/7858">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_4297"><div><strong>DiGeorge syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>4297</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0012236</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Individuals with 22q11.2 deletion syndrome (22q11.2DS) can present with a wide range of features that are highly variable, even within families. The major clinical manifestations of 22q11.2DS include congenital heart disease, particularly conotruncal malformations (ventricular septal defect, tetralogy of Fallot, interrupted aortic arch, and truncus arteriosus), palatal abnormalities (velopharyngeal incompetence, submucosal cleft palate, bifid uvula, and cleft palate), immune deficiency, characteristic facial features, and learning difficulties. Hearing loss can be sensorineural and/or conductive. Laryngotracheoesophageal, gastrointestinal, ophthalmologic, central nervous system, skeletal, and genitourinary anomalies also occur. Psychiatric illness and autoimmune disorders are more common in individuals with 22q11.2DS.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/4297">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_78649"><div><strong>Aspartylglucosaminuria</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>78649</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0268225</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Aspartylglucosaminuria is a lysosomal storage disorder characterized by developmental delay, intellectual disability, behavioral manifestations (hyperactivity in young children, anxiety and restlessness in adolescence, and apathy in adulthood), recurrent infections, musculoskeletal features, and characteristic craniofacial features (prominent supraorbital ridges, hypertelorism, periorbital fullness, short nose with broad nasal bridge, thick vermilion of the upper and lower lips, and macroglossia) that become more prominent with age. Additional neurologic manifestations can include seizures, poor balance and coordination, and progressive cerebral atrophy in adulthood. Macrocephaly is common. Musculoskeletal features include lordosis, scoliosis, and arthritis in adolescents and young adults; vertebral dysplasia and/or rib cage abnormalities; and progressive muscle wasting, joint contractures, bursitis, and osteoporosis in adulthood. Skin manifestations (facial seborrhea, rosacea, and angiofibromas), gastrointestinal manifestations, neutropenia, and thrombocytopenia occur in some individuals. The clinical manifestations of aspartylglucosaminuria worsen with age, and adults have progressive psychomotor decline.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/78649">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_336848"><div><strong>X-linked lymphoproliferative disease due to XIAP deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>336848</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C1845076</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">X-linked lymphoproliferative disease (XLP) in general is characterized by an inappropriate immune response to Epstein-Barr virus (EBV) infection leading to hemophagocytic lymphohistiocytosis (HLH) or severe mononucleosis, dysgammaglobulinemia, and lymphoproliferative disease (malignant lymphoma). The condition primarily affects males. XLP has two recognizable subtypes, XLP1 (due to pathogenic variants in SH2D1A) and XLP2 (due to pathogenic variants in XIAP). HLH / fulminant infectious mononucleosis is the most common presentation regardless of subtype. HLH is characterized as an acute illness with prolonged and high fever, bi- or trilineage cytopenias, and hepatosplenomegaly, which is often severe or fatal. Death is generally secondary to liver failure or multisystem organ dysfunction. In those with XLP1, dys- or hypogammaglobulinemia can lead to varying degrees of humoral immune dysfunction associated with bronchiectasis and recurrent respiratory infections that, if untreated, may result in death. Lymphoproliferative disease (malignant lymphoma) and other lymphoproliferative diseases are specific to XLP1 and often develop in childhood, usually following EBV exposure. Rarer findings in those with XLP1 can include aplastic anemia, vasculitis, and lymphoid granulomatosis. Males with XLP2 are more likely to have HLH without EBV infection, recurrent episodes of HLH (which is not typically seen in those with XLP1), splenomegaly, and gastrointestinal disease, including enterocolitis and perirectal abscesses or fistulae. Rarely, individuals with XLP2 and inflammatory bowel disease have been reported to develop inflammatory liver disease, which can progress to fatal liver failure. Transient hypogammaglobulinemia has been rarely observed in those with XLP2. To date, neither lymphoproliferative disease nor common variable immunodeficiency has been reported in males with XLP2. Heterozygous females rarely have symptoms. There are, however, increasing numbers of reports of affected females with unfavorable (skewed) X-chromosome inactivation favoring the X chromosome with the pathogenic variant who develop HLH, inflammatory bowel disease, and erythema nodosum.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/336848">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_383652"><div><strong>Frank-Ter Haar syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>383652</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1855305</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">The primary characteristics of the Frank-ter Haar syndrome (FTHS) are brachycephaly, wide fontanels, prominent forehead, hypertelorism, prominent eyes, macrocornea with or without glaucoma, full cheeks, small chin, bowing of the long bones, and flexion deformity of the fingers. Protruding, simple ears and prominent coccyx are also regarded as important diagnostic signs (summary by Maas et al., 2004). Borrone syndrome was described as a severe progressive multisystem disorder with features overlapping those of FTHS, including thick skin, acne conglobata, osteolysis, gingival hypertrophy, brachydactyly, camptodactyly, and mitral valve prolapse. Although it was initially thought to be a distinct phenotype, mutations in the FTHS-associated gene SH3PXD2B have been identified in patients diagnosed with Borrone syndrome. The earlier differential description was attributed to phenotypic variability as well as to differences in the ages at which patients were examined (Wilson et al., 2014).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/383652">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_346801"><div><strong>Pyogenic arthritis-pyoderma gangrenosum-acne syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>346801</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1858361</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) is a rare autosomal dominant autoinflammatory disease that typically presents with recurrent sterile, erosive arthritis in childhood, occurring spontaneously or after minor trauma, occasionally resulting in significant joint destruction. By puberty, joint symptoms tend to subside and cutaneous symptoms predominate, including pathergy, frequently with abscesses at the sites of injections, severe cystic acne, and recurrent nonhealing sterile ulcers, often diagnosed as pyoderma gangrenosum (summary by Demidowich et al., 2012).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/346801">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_382429"><div><strong>Hypertrophic osteoarthropathy, primary, autosomal dominant</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>382429</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2674695</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Autosomal dominant primary hypertrophic osteoarthropathy (PHOAD) is characterized by 3 major features: digital clubbing, periostosis, and pachydermia. Patients may also experience joint swelling and pain, and some have reported gastrointestinal symptoms, including watery diarrhea. Males are more commonly affected, and more severely affected, than females (Lee et al., 2016; Xu et al., 2021). Touraine et al. (1935) recognized pachydermoperiostosis (PDP) as a familial disorder with 3 presentations or forms: a complete form with periostosis and pachydermia, an incomplete form without pachydermia, and a forme fruste with pachydermia and minimal skeletal changes. Genetic Heterogeneity Autosomal recessive forms of PHO have been reported (see 259100), including PHOAR2E (614441), which is also caused by mutation in the SLCO2A1 gene. Patients with autosomal recessive PHO do not experience gastrointestinal symptoms.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/382429">Condition Record</a></div></div>
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||
<div class="divPopper rprt" id="rdis_390686"><div><strong>Mullerian aplasia and hyperandrogenism</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>390686</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2675014</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Müllerian aplasia and hyperandrogenism is a condition that affects the reproductive system in females. This condition is caused by abnormal development of the Müllerian ducts, which are structures in the embryo that develop into the uterus, fallopian tubes, cervix, and the upper part of the vagina. Individuals with Müllerian aplasia and hyperandrogenism typically have an underdeveloped or absent uterus and may also have abnormalities of other reproductive organs. Women with this condition have normal female external genitalia, and they develop breasts and pubic hair normally at puberty; however, they do not begin menstruation by age 16 (primary amenorrhea) and will likely never have a menstrual period. Affected women are unable to have children (infertile).\n\nWomen with Müllerian aplasia and hyperandrogenism have higher-than-normal levels of male sex hormones called androgens in their blood (hyperandrogenism), which can cause acne and excessive facial hair (facial hirsutism). Kidney abnormalities may be present in some affected individuals.</div>
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||
<div class="spaceAbove nowrap">See: <a href="/medgen/390686">Condition Record</a></div></div>
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||
<div class="divPopper rprt" id="rdis_411234"><div><strong>Spondyloepimetaphyseal dysplasia, PAPSS2 type</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>411234</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2748515</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
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||
<div class="spaceAbove">This form of brachyolmia, here designated brachyolmia type 4, is characterized by short-trunk stature with normal intelligence and facies. The radiographic features include rectangular vertebral bodies with irregular endplates and narrow intervertebral discs, precocious calcification of rib cartilages, short femoral neck, mildly shortened metacarpals, and mild epiphyseal and metaphyseal changes of the tubular bones (summary by Miyake et al., 2012).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/411234">Condition Record</a></div></div>
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||
<div class="divPopper rprt" id="rdis_482430"><div><strong>Hypertrophic osteoarthropathy, primary, autosomal recessive, 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>482430</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3280800</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">PHOAR2-enteropathy syndrome (PHOAR2E) is characterized by primary hypertrophic osteoarthropathy (PHO) and/or chronic nonspecific ulcers (CNSU) of the small intestine. The cardinal features of PHO are digital clubbing, pachydermia, and periostosis; other manifestations include swelling and pain of the large joints, hyperhidrosis, seborrhea, and acne. CNSU often presents with chronic unexplained anemia and abdominal pain, and patients may exhibit edema due to hypoalbuminemia. Radiologic imaging or endoscopy shows multiple small ulcers, predominantly in the ileum, although the stomach, duodenum, and jejunum are often involved. PHO is more frequent and more severe in male patients, who often also report watery diarrhea, whereas CNSU is more often diagnosed in female patients, who may also show features of PHO such as digital clubbing or arthralgias and swelling of the joints. The same mutations in the SLCO2A1 gene have been reported in patients presenting with either diagnosis, and presumed sex-related modifiers of the manifestations of disease or other genotype/phenotype correlates have yet to be elucidated (Li et al., 2017; Umeno et al., 2018; Hong et al., 2022; Kimball et al., 2024). For a discussion of genetic heterogeneity of PHO, see PHOAR1 (259100).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/482430">Condition Record</a></div></div>
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||
<div class="divPopper rprt" id="rdis_764630"><div><strong>Cortisone reductase deficiency 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>764630</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3551716</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Cortisone reductase deficiency (CRD) results from a failure to regenerate the active glucocorticoid cortisol from cortisone via the enzyme 11-beta-hydroxysteroid dehydrogenase (HSD11B1; 600713). The oxoreductase activity of 11-beta-HSD requires the NADPH-regenerating enzyme hexose-6-phosphate dehydrogenase (H6PD; 138090) within the endoplasmic reticulum. Lack of cortisol regeneration stimulates ACTH-mediated adrenal hyperandrogenism, with males manifesting in early life with precocious pseudopuberty and females presenting in midlife with hirsutism, oligomenorrhea, and infertility. Biochemically, CRD is diagnosed through the assessment of urinary cortisol and cortisone metabolites and consists of measuring the tetrahydrocortisol (THF) plus 5-alpha-THF/tetrahydrocortisone (THE) ratio, which in CRD patients is typically less than 0.1 (reference range, 0.7 to 1.2) (summary by Lavery et al., 2008). Genetic Heterogeneity of Cortisone Reductase Deficiency CORTRD2 (614662) is caused by mutation in the HSD11B1 gene (600713) on chromosome 1q32.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/764630">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_815580"><div><strong>Estrogen resistance syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>815580</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3809250</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Estrogen resistance (ESTRR) is characterized by absence of puberty with elevated estradiol and gonadotropic hormones, as well as markedly delayed bone maturation. Female patients show absent breast development, small uterus, and enlarged multicystic ovaries; male patients may show small testes (Bernard et al., 2017). Some patients exhibit continued growth into adulthood (Smith et al., 1994).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/815580">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_862862"><div><strong>Pigmented nodular adrenocortical disease, primary, 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>862862</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4014425</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Cushing syndrome is a clinical designation for the systemic signs and symptoms arising from excess cortisol production. Affected individuals typically show hypertension, impaired glucose tolerance, central obesity, osteoporosis, and sometimes depression. Corticotropin-independent Cushing syndrome results from autonomous cortisol production by the adrenal glands, often associated with adrenocortical tumors. Adrenocortical tumors are most common in adult females (summary by Cao et al., 2014; Sato et al., 2014).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/862862">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_7858" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Acrocephalosyndactyly type I</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_78649" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Aspartylglucosaminuria</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_764630" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cortisone reductase deficiency 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_4297" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">DiGeorge syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_815580" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Estrogen resistance syndrome</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (13)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_383652" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Frank-Ter Haar syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_382429" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypertrophic osteoarthropathy, primary, autosomal dominant</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_482430" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypertrophic osteoarthropathy, primary, autosomal recessive, 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_390686" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Mullerian aplasia and hyperandrogenism</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_862862" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pigmented nodular adrenocortical disease, primary, 4</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_346801" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pyogenic arthritis-pyoderma gangrenosum-acne syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_411234" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Spondyloepimetaphyseal dysplasia, PAPSS2 type</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_336848" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">X-linked lymphoproliferative disease due to XIAP deficiency</a></div></span></div></div>
|
||
</div>
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<div class="portlet mgSection" id="ID_105">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
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<div class="nl"><a target="_blank" href="/pubmed/38300170">Guidelines of care for the management of acne vulgaris.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Reynolds RV,
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Yeung H,
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Cheng CE,
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Cook-Bolden F,
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Desai SR,
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Druby KM,
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Freeman EE,
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Keri JE,
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Stein Gold LF,
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Tan JKL,
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Tollefson MM,
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Weiss JS,
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Wu PA,
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Zaenglein AL,
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Han JM,
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Barbieri JS</span><br />
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<span class="medgenPMjournal">J Am Acad Dermatol</span>
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2024 May;90(5):1006.e1-1006.e30.
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Epub 2024 Jan 30
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||
doi: 10.1016/j.jaad.2023.12.017.
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||
<span class="bold">PMID: </span><a href="/pubmed/38300170" target="_blank">38300170</a></div>
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||
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||
<div class="nl"><a target="_blank" href="/pubmed/27529209">Treatment Modalities for Acne.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Fox L,
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Csongradi C,
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Aucamp M,
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du Plessis J,
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||
Gerber M</span><br />
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||
<span class="medgenPMjournal">Molecules</span>
|
||
2016 Aug 13;21(8)
|
||
doi: 10.3390/molecules21081063.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27529209" target="_blank">27529209</a><a href="/pmc/articles/PMC6273829" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26897386">Guidelines of care for the management of acne vulgaris.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zaenglein AL,
|
||
Pathy AL,
|
||
Schlosser BJ,
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||
Alikhan A,
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||
Baldwin HE,
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||
Berson DS,
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||
Bowe WP,
|
||
Graber EM,
|
||
Harper JC,
|
||
Kang S,
|
||
Keri JE,
|
||
Leyden JJ,
|
||
Reynolds RV,
|
||
Silverberg NB,
|
||
Stein Gold LF,
|
||
Tollefson MM,
|
||
Weiss JS,
|
||
Dolan NC,
|
||
Sagan AA,
|
||
Stern M,
|
||
Boyer KM,
|
||
Bhushan R</span><br />
|
||
<span class="medgenPMjournal">J Am Acad Dermatol</span>
|
||
2016 May;74(5):945-73.e33.
|
||
Epub 2016 Feb 17
|
||
doi: 10.1016/j.jaad.2015.12.037.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26897386" target="_blank">26897386</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22acne%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (2123)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38154809">Managing acne vulgaris: an update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Santer M,
|
||
Burden-Teh E,
|
||
Ravenscroft J</span><br />
|
||
<span class="medgenPMjournal">Drug Ther Bull</span>
|
||
2023 Dec 27;62(1):6-10.
|
||
doi: 10.1136/dtb.2023.000051.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38154809" target="_blank">38154809</a><a href="/pmc/articles/PMC10803966" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36253244">Adult acne versus adolescent acne: a narrative review with a focus on epidemiology to treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kutlu Ö,
|
||
Karadağ AS,
|
||
Wollina U</span><br />
|
||
<span class="medgenPMjournal">An Bras Dermatol</span>
|
||
2023 Jan-Feb;98(1):75-83.
|
||
Epub 2022 Oct 14
|
||
doi: 10.1016/j.abd.2022.01.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36253244" target="_blank">36253244</a><a href="/pmc/articles/PMC9837660" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34114770">Associations between diet and acne lesions.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Daszkiewicz M</span><br />
|
||
<span class="medgenPMjournal">Rocz Panstw Zakl Hig</span>
|
||
2021;72(2):137-143.
|
||
doi: 10.32394/rpzh.2021.0164.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34114770" target="_blank">34114770</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32238884">Systematic review of the epidemiology of acne vulgaris.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Heng AHS,
|
||
Chew FT</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2020 Apr 1;10(1):5754.
|
||
doi: 10.1038/s41598-020-62715-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32238884" target="_blank">32238884</a><a href="/pmc/articles/PMC7113252" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23062156">Diagnosis and treatment of acne.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Titus S,
|
||
Hodge J</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2012 Oct 15;86(8):734-40.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23062156" target="_blank">23062156</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acne%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5286)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35792196">Acne scarring-pathophysiology, diagnosis, prevention and education: Part I.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jennings T,
|
||
Duffy R,
|
||
McLarney M,
|
||
Renzi M,
|
||
Heymann WR,
|
||
Decker A,
|
||
Lawrence N</span><br />
|
||
<span class="medgenPMjournal">J Am Acad Dermatol</span>
|
||
2024 Jun;90(6):1123-1134.
|
||
Epub 2022 Jul 2
|
||
doi: 10.1016/j.jaad.2022.04.021.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35792196" target="_blank">35792196</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35841269">Acne treatment review and future perspectives.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mohsin N,
|
||
Hernandez LE,
|
||
Martin MR,
|
||
Does AV,
|
||
Nouri K</span><br />
|
||
<span class="medgenPMjournal">Dermatol Ther</span>
|
||
2022 Sep;35(9):e15719.
|
||
Epub 2022 Jul 26
|
||
doi: 10.1111/dth.15719.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35841269" target="_blank">35841269</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34826281">Acne Vulgaris.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Heath CR,
|
||
Usatine RP</span><br />
|
||
<span class="medgenPMjournal">Cutis</span>
|
||
2021 Sep;108(3):167.
|
||
doi: 10.12788/cutis.0339.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34826281" target="_blank">34826281</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31294907">Acne and rosacea: What's new for treatment?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dursun R,
|
||
Daye M,
|
||
Durmaz K</span><br />
|
||
<span class="medgenPMjournal">Dermatol Ther</span>
|
||
2019 Sep;32(5):e13020.
|
||
Epub 2019 Jul 22
|
||
doi: 10.1111/dth.13020.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31294907" target="_blank">31294907</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27529209">Treatment Modalities for Acne.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fox L,
|
||
Csongradi C,
|
||
Aucamp M,
|
||
du Plessis J,
|
||
Gerber M</span><br />
|
||
<span class="medgenPMjournal">Molecules</span>
|
||
2016 Aug 13;21(8)
|
||
doi: 10.3390/molecules21081063.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27529209" target="_blank">27529209</a><a href="/pmc/articles/PMC6273829" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acne%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3703)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36260792">Two Phase 3, Randomized, Controlled Trials of Ruxolitinib Cream for Vitiligo.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rosmarin D,
|
||
Passeron T,
|
||
Pandya AG,
|
||
Grimes P,
|
||
Harris JE,
|
||
Desai SR,
|
||
Lebwohl M,
|
||
Ruer-Mulard M,
|
||
Seneschal J,
|
||
Wolkerstorfer A,
|
||
Kornacki D,
|
||
Sun K,
|
||
Butler K,
|
||
Ezzedine K;
|
||
TRuE-V Study Group</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2022 Oct 20;387(16):1445-1455.
|
||
doi: 10.1056/NEJMoa2118828.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36260792" target="_blank">36260792</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34564936">Role of nutritional supplements in selected dermatological disorders: A review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sardana K,
|
||
Sachdeva S</span><br />
|
||
<span class="medgenPMjournal">J Cosmet Dermatol</span>
|
||
2022 Jan;21(1):85-98.
|
||
Epub 2021 Sep 26
|
||
doi: 10.1111/jocd.14436.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34564936" target="_blank">34564936</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27755171">Microneedling: A Comprehensive Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hou A,
|
||
Cohen B,
|
||
Haimovic A,
|
||
Elbuluk N</span><br />
|
||
<span class="medgenPMjournal">Dermatol Surg</span>
|
||
2017 Mar;43(3):321-339.
|
||
doi: 10.1097/DSS.0000000000000924.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27755171" target="_blank">27755171</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15025547">Ethinylestradiol/chlormadinone acetate.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Curran MP,
|
||
Wagstaff AJ</span><br />
|
||
<span class="medgenPMjournal">Drugs</span>
|
||
2004;64(7):751-60; discussion 761-2.
|
||
doi: 10.2165/00003495-200464070-00005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15025547" target="_blank">15025547</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9585866">Tazarotene.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Foster RH,
|
||
Brogden RN,
|
||
Benfield P</span><br />
|
||
<span class="medgenPMjournal">Drugs</span>
|
||
1998 May;55(5):705-11; discussion 712.
|
||
doi: 10.2165/00003495-199855050-00008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9585866" target="_blank">9585866</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acne%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (8932)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33085149">Systematic review of low-dose isotretinoin for treatment of acne vulgaris: Focus on indication, dosage, regimen, efficacy, safety, satisfaction, and follow up, based on clinical studies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sadeghzadeh-Bazargan A,
|
||
Ghassemi M,
|
||
Goodarzi A,
|
||
Roohaninasab M,
|
||
Najar Nobari N,
|
||
Behrangi E</span><br />
|
||
<span class="medgenPMjournal">Dermatol Ther</span>
|
||
2021 Jan;34(1):e14438.
|
||
Epub 2020 Dec 6
|
||
doi: 10.1111/dth.14438.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33085149" target="_blank">33085149</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29464224">Acne in adolescents.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gebauer K</span><br />
|
||
<span class="medgenPMjournal">Aust Fam Physician</span>
|
||
2017 Dec;46(12):892-895.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29464224" target="_blank">29464224</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26897386">Guidelines of care for the management of acne vulgaris.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zaenglein AL,
|
||
Pathy AL,
|
||
Schlosser BJ,
|
||
Alikhan A,
|
||
Baldwin HE,
|
||
Berson DS,
|
||
Bowe WP,
|
||
Graber EM,
|
||
Harper JC,
|
||
Kang S,
|
||
Keri JE,
|
||
Leyden JJ,
|
||
Reynolds RV,
|
||
Silverberg NB,
|
||
Stein Gold LF,
|
||
Tollefson MM,
|
||
Weiss JS,
|
||
Dolan NC,
|
||
Sagan AA,
|
||
Stern M,
|
||
Boyer KM,
|
||
Bhushan R</span><br />
|
||
<span class="medgenPMjournal">J Am Acad Dermatol</span>
|
||
2016 May;74(5):945-73.e33.
|
||
Epub 2016 Feb 17
|
||
doi: 10.1016/j.jaad.2015.12.037.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26897386" target="_blank">26897386</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25077885">Inositol and acne.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pezza M,
|
||
Carlomagno V,
|
||
Casucci G</span><br />
|
||
<span class="medgenPMjournal">G Ital Dermatol Venereol</span>
|
||
2015 Dec;150(6):649-53.
|
||
Epub 2014 Jul 31
|
||
<span class="bold">PMID: </span><a href="/pubmed/25077885" target="_blank">25077885</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15261171">Acne vulgaris.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Robertson KM</span><br />
|
||
<span class="medgenPMjournal">Facial Plast Surg Clin North Am</span>
|
||
2004 Aug;12(3):347-55, vi.
|
||
doi: 10.1016/j.fsc.2004.03.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15261171" target="_blank">15261171</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acne%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1686)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38380975">Efficacy of Spironolactone Compared with Doxycycline in Moderate Acne in Adult Females: Results of the Multicentre, Controlled, Randomized, Double-blind Prospective and Parallel Female Acne Spironolactone vs doxyCycline Efficacy (FASCE) Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dréno B,
|
||
Nguyen JM,
|
||
Hainaut E,
|
||
Machet L,
|
||
Leccia MT,
|
||
Beneton N,
|
||
Claudel JP,
|
||
Célérier P,
|
||
Le Moigne M,
|
||
Le Naour S,
|
||
Vrignaud F,
|
||
Poinas A,
|
||
Dert C,
|
||
Boisrobert A,
|
||
Flet L,
|
||
Korner S,
|
||
Khammari A</span><br />
|
||
<span class="medgenPMjournal">Acta Derm Venereol</span>
|
||
2024 Feb 21;104:adv26002.
|
||
doi: 10.2340/actadv.v104.26002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38380975" target="_blank">38380975</a><a href="/pmc/articles/PMC10910526" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37892480">Dietary Patterns in Acne and Rosacea Patients-A Controlled Study and Comprehensive Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Guertler A,
|
||
Volsky A,
|
||
Eijkenboom Q,
|
||
Fiedler T,
|
||
French LE,
|
||
Reinholz M</span><br />
|
||
<span class="medgenPMjournal">Nutrients</span>
|
||
2023 Oct 17;15(20)
|
||
doi: 10.3390/nu15204405.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37892480" target="_blank">37892480</a><a href="/pmc/articles/PMC10609993" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37192767">Effectiveness of spironolactone for women with acne vulgaris (SAFA) in England and Wales: pragmatic, multicentre, phase 3, double blind, randomised controlled trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Santer M,
|
||
Lawrence M,
|
||
Renz S,
|
||
Eminton Z,
|
||
Stuart B,
|
||
Sach TH,
|
||
Pyne S,
|
||
Ridd MJ,
|
||
Francis N,
|
||
Soulsby I,
|
||
Thomas K,
|
||
Permyakova N,
|
||
Little P,
|
||
Muller I,
|
||
Nuttall J,
|
||
Griffiths G,
|
||
Thomas KS,
|
||
Layton AM;
|
||
SAFA trial investigators</span><br />
|
||
<span class="medgenPMjournal">BMJ</span>
|
||
2023 May 16;381:e074349.
|
||
doi: 10.1136/bmj-2022-074349.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37192767" target="_blank">37192767</a><a href="/pmc/articles/PMC10543374" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32113677">Demodex folliculorum infestations in common facial dermatoses: acne vulgaris, rosacea, seborrheic dermatitis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Aktaş Karabay E,
|
||
Aksu Çerman A</span><br />
|
||
<span class="medgenPMjournal">An Bras Dermatol</span>
|
||
2020 Mar-Apr;95(2):187-193.
|
||
Epub 2020 Feb 12
|
||
doi: 10.1016/j.abd.2019.08.023.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32113677" target="_blank">32113677</a><a href="/pmc/articles/PMC7175027" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28291553">Isotretinoin treatment for acne and risk of depression: A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Huang YC,
|
||
Cheng YC</span><br />
|
||
<span class="medgenPMjournal">J Am Acad Dermatol</span>
|
||
2017 Jun;76(6):1068-1076.e9.
|
||
Epub 2017 Mar 11
|
||
doi: 10.1016/j.jaad.2016.12.028.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28291553" target="_blank">28291553</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acne%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3383)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/38300170">Guidelines of care for the management of acne vulgaris.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Reynolds RV,
|
||
Yeung H,
|
||
Cheng CE,
|
||
Cook-Bolden F,
|
||
Desai SR,
|
||
Druby KM,
|
||
Freeman EE,
|
||
Keri JE,
|
||
Stein Gold LF,
|
||
Tan JKL,
|
||
Tollefson MM,
|
||
Weiss JS,
|
||
Wu PA,
|
||
Zaenglein AL,
|
||
Han JM,
|
||
Barbieri JS</span><br />
|
||
<span class="medgenPMjournal">J Am Acad Dermatol</span>
|
||
2024 May;90(5):1006.e1-1006.e30.
|
||
Epub 2024 Jan 30
|
||
doi: 10.1016/j.jaad.2023.12.017.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38300170" target="_blank">38300170</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35789996">A systematic review and network meta-analysis of topical pharmacological, oral pharmacological, physical and combined treatments for acne vulgaris.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mavranezouli I,
|
||
Daly CH,
|
||
Welton NJ,
|
||
Deshpande S,
|
||
Berg L,
|
||
Bromham N,
|
||
Arnold S,
|
||
Phillippo DM,
|
||
Wilcock J,
|
||
Xu J,
|
||
Ravenscroft JC,
|
||
Wood D,
|
||
Rafiq M,
|
||
Fou L,
|
||
Dworzynski K,
|
||
Healy E</span><br />
|
||
<span class="medgenPMjournal">Br J Dermatol</span>
|
||
2022 Nov;187(5):639-649.
|
||
Epub 2022 Aug 22
|
||
doi: 10.1111/bjd.21739.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35789996" target="_blank">35789996</a><a href="/pmc/articles/PMC9804728" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32702243">Whey protein supplementation and its potentially adverse effects on health: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vasconcelos QDJS,
|
||
Bachur TPR,
|
||
Aragão GF</span><br />
|
||
<span class="medgenPMjournal">Appl Physiol Nutr Metab</span>
|
||
2021 Jan;46(1):27-33.
|
||
Epub 2020 Jul 23
|
||
doi: 10.1139/apnm-2020-0370.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32702243" target="_blank">32702243</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32238884">Systematic review of the epidemiology of acne vulgaris.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Heng AHS,
|
||
Chew FT</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2020 Apr 1;10(1):5754.
|
||
doi: 10.1038/s41598-020-62715-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32238884" target="_blank">32238884</a><a href="/pmc/articles/PMC7113252" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27498379">Body dysmorphic disorder in different settings: A systematic review and estimated weighted prevalence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Veale D,
|
||
Gledhill LJ,
|
||
Christodoulou P,
|
||
Hodsoll J</span><br />
|
||
<span class="medgenPMjournal">Body Image</span>
|
||
2016 Sep;18:168-86.
|
||
Epub 2016 Aug 4
|
||
doi: 10.1016/j.bodyim.2016.07.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27498379" target="_blank">27498379</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acne%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (366)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0702166%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (5)</a></li>
|
||
<li><a href="/gtr/tests?term=C0702166%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (5)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0702166%5bDISCUI%5d" target="_blank">See all (5)</a></total></li>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Acne" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22acne%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Acne%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Acne" target="_blank">MedlinePlus</a></li></ul></div>
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<a href="/pubmed/clinical?term=Acne" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
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<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0702166[DISCUI]" ref="log$=recordlinks">GTR</a>
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<a class="brieflinkpopperctrl" href="/mesh?LinkName=medgen_mesh&from_uid=152379" ref="log$=recordlinks">MeSH</a>
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<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory">
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Turn On
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<ul id="activity">
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<li class="ra_rcd ralinkpopper two_line">
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||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67d5abda84f3725e59a7bf69">Acne</a>
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<div class="ralinkpop offscreen_noflow">Acne<div class="brieflinkpopdesc"></div></div>
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<div class="tertiary">MedGen</div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67d5abd767c23b31e02b6f65">Folliculitis</a>
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<div class="ralinkpop offscreen_noflow">Folliculitis<div class="brieflinkpopdesc"></div></div>
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