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<meta name="keywords" content="C0687150, adenocarcinoma of parathyroid, adenocarcinoma of parathyroid gland, adenocarcinoma of the parathyroid, adenocarcinoma of the parathyroid gland, cancer of parathyroid, cancer of parathyroid gland, cancer of the parathyroid, cancer of the parathyroid gland, cancer, parathyroid, cancers, parathyroid, carcinoma of parathyroid, carcinoma of parathyroid gland, carcinoma of the parathyroid, carcinoma of the parathyroid gland, carcinoma, parathyroid, carcinomas, parathyroid, cdc73, cdc73-related parathyroid carcinoma, neoplastic process, parathyroid adenocarcinoma, parathyroid cancer, parathyroid cancers, parathyroid carcinoma, parathyroid carcinomas, parathyroid gland adenocarcinoma, parathyroid gland cancer, parathyroid gland carcinoma, prtc, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="The spectrum of CDC73-related disorders includes the following phenotypes: Hyperparathyroidism-jaw tumor (HPT-JT) syndrome. Primary hyperparathyroidism occurs in a vast majority of affected individuals, with onset typically in late adolescence or early adulthood. HPT-JT syndrome-associated primary hyperparathyroidism is usually caused by a single parathyroid adenoma. In at least 10%-15% of individuals, primary hyperparathyroidism is caused by parathyroid carcinoma. Ossifying fibromas of the mandible or maxilla, also known as cementifying fibromas and cemento-ossifying fibromas, occur in 30%-40% of individuals with HPT-JT syndrome. Although benign, these tumors can be locally aggressive and may continue to enlarge if not treated. Up to 20% of individuals with HPT-JT syndrome have kidney lesions, most commonly cysts; renal hamartomas and (more rarely) Wilms tumor have also been reported. Benign uterine tumors appear to be common in women with HPT-JT syndrome; uterine malignancies have also been reported. Parathyroid carcinoma. Most parathyroid carcinomas are functional, resulting in primary hyperparathyroidism and a high serum calcium level; however, nonfunctioning parathyroid carcinomas are also rarely described in individuals with a CDC73-related disorder. A germline CDC73 pathogenic variant has been identified in 20%-29% of individuals with parathyroid carcinoma without a known family history of CDC73-related conditions. Familial isolated hyperparathyroidism (FIHP). Characterized by primary hyperparathyroidism without other associated syndromic features. Individuals with CDC73-related FIHP tend to have a more severe clinical presentation and younger age of onset than individuals with FIHP in whom a CDC73 pathogenic variant has not been identified." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
UID=146361
ConceptID=C0687150
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Parathyroid carcinoma<span class="h1sub">(PRTC)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>146361</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C0687150</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>CDC73-Related Parathyroid Carcinoma; Parathyroid cancer; Parathyroid gland carcinoma; PRTC</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Parathyroid cancer (363481002); Parathyroid carcinoma (255037004)</td></tr>
<tr><td>Modes of inheritance:</td>
<td>
<div class="divPopper rprt" id="moi_988794"><div><strong>Not genetically inherited</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>988794</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms&#10;that cannot be identified in NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">CN307044</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
<div class="spaceAbove">Source: Orphanet</div>
<div class="spaceAbove">clinical entity without genetic inheritance.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/988794">This record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_988794" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Not genetically inherited</a><span> (Orphanet)</span></div></td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
Gene(s) directly associated with<br />
this condition or phenotype.</div></td>
<td><a target="_blank" title="CDC73 - ID: 79577 - NCBI Gene" href="/gene/79577" class="medgenPMinfo">CDC73</a> (1q31.2)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0006780">HP:0006780</a></td></tr>
<tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0012004" target="_blank">MONDO:0012004</a></td></tr>
<tr><td>OMIM<span class="superscript">®</span>:</td>
<td><a href="https://omim.org/entry/608266" target="_blank">608266</a></td></tr>
<tr><td>Orphanet:</td>
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&amp;Expert=143">ORPHA143</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_101">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Disease_characteristics">Disease characteristics</h1><a sid="101" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><div class="excerpt">Excerpted from the <i>GeneReview: </i><a href="/books/NBK3789" target="_blank">CDC73-Related Disorders</a></div><div>The spectrum of CDC73-related disorders includes the following phenotypes: Hyperparathyroidism-jaw tumor (HPT-JT) syndrome. Primary hyperparathyroidism occurs in a vast majority of affected individuals, with onset typically in late adolescence or early adulthood. HPT-JT syndrome-associated primary hyperparathyroidism is usually caused by a single parathyroid adenoma. In at least 10%-15% of individuals, primary hyperparathyroidism is caused by parathyroid carcinoma. Ossifying fibromas of the mandible or maxilla, also known as cementifying fibromas and cemento-ossifying fibromas, occur in 30%-40% of individuals with HPT-JT syndrome. Although benign, these tumors can be locally aggressive and may continue to enlarge if not treated. Up to 20% of individuals with HPT-JT syndrome have kidney lesions, most commonly cysts; renal hamartomas and (more rarely) Wilms tumor have also been reported. Benign uterine tumors appear to be common in women with HPT-JT syndrome; uterine malignancies have also been reported. Parathyroid carcinoma. Most parathyroid carcinomas are functional, resulting in primary hyperparathyroidism and a high serum calcium level; however, nonfunctioning parathyroid carcinomas are also rarely described in individuals with a CDC73-related disorder. A germline CDC73 pathogenic variant has been identified in 20%-29% of individuals with parathyroid carcinoma without a known family history of CDC73-related conditions. Familial isolated hyperparathyroidism (FIHP). Characterized by primary hyperparathyroidism without other associated syndromic features. Individuals with CDC73-related FIHP tend to have a more severe clinical presentation and younger age of onset than individuals with FIHP in whom a CDC73 pathogenic variant has not been identified. [from <a title="GeneReviews" href="https://www.ncbi.nlm.nih.gov/books/NBK1116" class="defSource" target="_blank">GeneReviews</a>]</div><div class="spaceAbove"><strong>Full text of <i>GeneReview</i> (by section):</strong><br /><a class="medgenPMinfo" href="/books/NBK3789#hrpt2.Summary" target="NBK3789">Summary</a>  |  <a class="medgenPMinfo" href="/books/NBK3789#hrpt2.GeneReview_Scope" target="NBK3789">GeneReview Scope</a>  |  <a class="medgenPMinfo" href="/books/NBK3789#hrpt2.Diagnosis" target="NBK3789">Diagnosis</a>  |  <a class="medgenPMinfo" href="/books/NBK3789#hrpt2.Clinical_Characteristics" target="NBK3789">Clinical Characteristics</a>  |  <a class="medgenPMinfo" href="/books/NBK3789#hrpt2.Genetically_Related_Allelic_Disord" target="NBK3789">Genetically Related (Allelic) Disorders</a>  |  <a class="medgenPMinfo" href="/books/NBK3789#hrpt2.Differential_Diagnosis" target="NBK3789">Differential Diagnosis</a>  |  <a class="medgenPMinfo" href="/books/NBK3789#hrpt2.Management" target="NBK3789">Management</a>  |  <a class="medgenPMinfo" href="/books/NBK3789#hrpt2.Genetic_Counseling" target="NBK3789">Genetic Counseling</a>  |  <a class="medgenPMinfo" href="/books/NBK3789#hrpt2.Resources" target="NBK3789">Resources</a>  |  <a class="medgenPMinfo" href="/books/NBK3789#hrpt2.Molecular_Genetics" target="NBK3789">Molecular Genetics</a>  |  <a class="medgenPMinfo" href="/books/NBK3789#hrpt2.Chapter_Notes" target="NBK3789">Chapter Notes</a>  |  <a class="medgenPMinfo" href="/books/NBK3789#hrpt2.References" target="NBK3789">References</a></div><div class="spaceAbove"><strong>Authors:</strong><br />
Catherine M Skefos  |  Steven G Waguespack  |  Nancy D Perrier<i>, et. al.</i>   <a href="/books/NBK3789" target="NBK3789" title="NCBI Bookshelf: CDC73-Related Disorders">view full author information</a></div></div>
</div>
<div class="portlet mgSection" id="ID_117">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Additional_description">Additional description</h1><a sid="117" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><div class="mgSection"><strong>From MedlinePlus Genetics</strong><br />Parathyroid cancer is a rare cancer that usually affects people in their forties or fifties and occurs in one of the four parathyroid glands. The parathyroid glands are located in the neck and secrete parathyroid hormone, which enhances the release of calcium into the blood.<br /><br />In about 90 percent of cases, the early signs of parathyroid cancer are high levels of parathyroid hormone (hyperparathyroidism) and calcium (hypercalcemia) in the blood. In these cases, the cancer is described as hormonally functional because the parathyroid glands are producing excess hormone.<br /><br />Many individuals with hormonally functional parathyroid cancer develop hypercalcemic crisis, in which calcium levels in the blood are very high. Neurological problems can develop, including changes in mood and depression. About 30 percent of individuals with hypercalcemia due to parathyroid cancer develop kidney and skeletal problems. These problems include increased urine production (polyuria), deposits of calcium in the kidneys (nephrocalcinosis) leading to the formation of kidney stones (nephrolithiasis), bone pain, bone loss, and increased bone fractures. Abdominal pain, inflammation of the pancreas (pancreatitis), sores (ulcers) in the lining of the digestive tract, nausea, vomiting, weight loss, and fatigue are also common.<br /><br />About 10 percent of cases of parathyroid cancer are described as hormonally nonfunctional. In these cases, levels of parathyroid hormone and calcium are normal. The signs and symptoms of hormonally nonfunctional parathyroid cancer are related to the tumor obstructing nearby structures in the neck. These problems include difficulty swallowing (dysphagia) and speaking (dysarthria), a hoarse voice, shortness of breath (dyspnea), or vocal cord paralysis.<br /><br />Up to 85 percent of individuals with parathyroid survive at least 5 years after they are diagnosed. The disease recurs in approximately half of individuals. If cancer does recur, it will commonly be within 3 years of the original diagnosis and up to 78 percent of people with recurrent cancer survive at least 5 years. Hormonally nonfunctional parathyroid cancer has a lower survival rate because it is often found at a later stage, as it does not have early signs such as increased calcium and parathyroid hormone levels.<br /><br />In hormonally functional parathyroid cancer, death is usually caused by organ failure (usually kidney failure) due to prolonged hypercalcemia and not directly due to the tumor. In hormonally nonfunctional parathyroid cancer, the cause of death is typically related to the tumor itself, such as its impact on the function of nearby structures or its spread to other tissues (metastasis).  <a target="_blank" href="https://medlineplus.gov/genetics/condition/parathyroid-cancer">https://medlineplus.gov/genetics/condition/parathyroid-cancer</a></div></div>
</div>
<div class="portlet mgSection" id="ID_102">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
<div class="divPopper rprt" id="clin_146361"><div><strong>Parathyroid carcinoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>146361</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C0687150</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
<div class="spaceAbove">The spectrum of CDC73-related disorders includes the following phenotypes: Hyperparathyroidism-jaw tumor (HPT-JT) syndrome. Primary hyperparathyroidism occurs in a vast majority of affected individuals, with onset typically in late adolescence or early adulthood. HPT-JT syndrome-associated primary hyperparathyroidism is usually caused by a single parathyroid adenoma. In at least 10%-15% of individuals, primary hyperparathyroidism is caused by parathyroid carcinoma. Ossifying fibromas of the mandible or maxilla, also known as cementifying fibromas and cemento-ossifying fibromas, occur in 30%-40% of individuals with HPT-JT syndrome. Although benign, these tumors can be locally aggressive and may continue to enlarge if not treated. Up to 20% of individuals with HPT-JT syndrome have kidney lesions, most commonly cysts; renal hamartomas and (more rarely) Wilms tumor have also been reported. Benign uterine tumors appear to be common in women with HPT-JT syndrome; uterine malignancies have also been reported. Parathyroid carcinoma. Most parathyroid carcinomas are functional, resulting in primary hyperparathyroidism and a high serum calcium level; however, nonfunctioning parathyroid carcinomas are also rarely described in individuals with a CDC73-related disorder. A germline CDC73 pathogenic variant has been identified in 20%-29% of individuals with parathyroid carcinoma without a known family history of CDC73-related conditions. Familial isolated hyperparathyroidism (FIHP). Characterized by primary hyperparathyroidism without other associated syndromic features. Individuals with CDC73-related FIHP tend to have a more severe clinical presentation and younger age of onset than individuals with FIHP in whom a CDC73 pathogenic variant has not been identified.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/146361">Feature record</a> | <a href="/medgen?term=%22Parathyroid%20carcinoma%22%5BClinical%20Features%5D%20OR%20146361%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_5686"><div><strong>Hypercalcemia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>5686</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0020437</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">An abnormally increased calcium concentration in the blood.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/5686">Feature record</a> | <a href="/medgen?term=%22Hypercalcemia%22%5BClinical%20Features%5D%20OR%205686%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_6967"><div><strong>Hyperparathyroidism</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>6967</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0020502</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Excessive production of parathyroid hormone (PTH) by the parathyroid glands.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/6967">Feature record</a> | <a href="/medgen?term=%22Hyperparathyroidism%22%5BClinical%20Features%5D%20OR%206967%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(&quot;.TreeLite&quot;,&quot;#ID_102&quot;).TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(&quot;.TreeLite&quot;,&quot;#ID_102&quot;).TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of metabolism/homeostasis</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_5686" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypercalcemia</a></span></li></ul></li><li><span class="TLline">Abnormality of the endocrine system</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_6967" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hyperparathyroidism</a></span></li></ul></li><li><span class="TLline">Neoplasm</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_146361" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Parathyroid carcinoma</a></span></li></ul></li></ul></div></div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li><li><a href="#tabORDO">Orphanet</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0687150[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=146361">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=146361" target="_blank" href="/omim/607393">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK3789/" ref="ncbi_uid=146361">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=146361" ref="ncbi_uid=146361">V</a></span></span><span class="TLline">Parathyroid carcinoma</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/10294" ref="tree=MeSH" title="MedGen record for Neoplasm">Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/277963" ref="tree=MeSH" title="MedGen record for Epithelial neoplasm">Epithelial neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/2867" ref="tree=MeSH" title="MedGen record for Carcinoma">Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/122" ref="tree=MeSH" title="MedGen record for Adenocarcinoma">Adenocarcinoma</a></span><ul><li><span class="matched_ds">Parathyroid carcinoma</span><ul><li><span class="TLline"><a href="/medgen/859241" ref="tree=MeSH" title="MedGen record for Childhood Parathyroid Gland Carcinoma">Childhood Parathyroid Gland Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/82959" ref="tree=MeSH" title="MedGen record for Localized Parathyroid Gland Carcinoma">Localized Parathyroid Gland Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/82960" ref="tree=MeSH" title="MedGen record for Metastatic Parathyroid Gland Carcinoma">Metastatic Parathyroid Gland Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1716274" ref="tree=MeSH" title="MedGen record for Locally Advanced Parathyroid Gland Carcinoma">Locally Advanced Parathyroid Gland Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/75854" ref="tree=MeSH" title="MedGen record for Recurrent Parathyroid Gland Carcinoma">Recurrent Parathyroid Gland Carcinoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div><div id="tabORDO">Follow <a target="_blank" href="http://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&amp;data_id=156&amp;PatId=8675&amp;search=Disease_Classif_Simple&amp;new=1" class="ital bold">this link</a> to review classifications for <span class="ital">Parathyroid carcinoma</span> in Orphanet.</div></div></div>
</div>
<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_146361"><div><strong>Parathyroid carcinoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>146361</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C0687150</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
<div class="spaceAbove">The spectrum of CDC73-related disorders includes the following phenotypes: Hyperparathyroidism-jaw tumor (HPT-JT) syndrome. Primary hyperparathyroidism occurs in a vast majority of affected individuals, with onset typically in late adolescence or early adulthood. HPT-JT syndrome-associated primary hyperparathyroidism is usually caused by a single parathyroid adenoma. In at least 10%-15% of individuals, primary hyperparathyroidism is caused by parathyroid carcinoma. Ossifying fibromas of the mandible or maxilla, also known as cementifying fibromas and cemento-ossifying fibromas, occur in 30%-40% of individuals with HPT-JT syndrome. Although benign, these tumors can be locally aggressive and may continue to enlarge if not treated. Up to 20% of individuals with HPT-JT syndrome have kidney lesions, most commonly cysts; renal hamartomas and (more rarely) Wilms tumor have also been reported. Benign uterine tumors appear to be common in women with HPT-JT syndrome; uterine malignancies have also been reported. Parathyroid carcinoma. Most parathyroid carcinomas are functional, resulting in primary hyperparathyroidism and a high serum calcium level; however, nonfunctioning parathyroid carcinomas are also rarely described in individuals with a CDC73-related disorder. A germline CDC73 pathogenic variant has been identified in 20%-29% of individuals with parathyroid carcinoma without a known family history of CDC73-related conditions. Familial isolated hyperparathyroidism (FIHP). Characterized by primary hyperparathyroidism without other associated syndromic features. Individuals with CDC73-related FIHP tend to have a more severe clinical presentation and younger age of onset than individuals with FIHP in whom a CDC73 pathogenic variant has not been identified.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/146361">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_310065"><div><strong>Hyperparathyroidism 2 with jaw tumors</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>310065</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1704981</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">The spectrum of CDC73-related disorders includes the following phenotypes: Hyperparathyroidism-jaw tumor (HPT-JT) syndrome. Primary hyperparathyroidism occurs in a vast majority of affected individuals, with onset typically in late adolescence or early adulthood. HPT-JT syndrome-associated primary hyperparathyroidism is usually caused by a single parathyroid adenoma. In at least 10%-15% of individuals, primary hyperparathyroidism is caused by parathyroid carcinoma. Ossifying fibromas of the mandible or maxilla, also known as cementifying fibromas and cemento-ossifying fibromas, occur in 30%-40% of individuals with HPT-JT syndrome. Although benign, these tumors can be locally aggressive and may continue to enlarge if not treated. Up to 20% of individuals with HPT-JT syndrome have kidney lesions, most commonly cysts; renal hamartomas and (more rarely) Wilms tumor have also been reported. Benign uterine tumors appear to be common in women with HPT-JT syndrome; uterine malignancies have also been reported. Parathyroid carcinoma. Most parathyroid carcinomas are functional, resulting in primary hyperparathyroidism and a high serum calcium level; however, nonfunctioning parathyroid carcinomas are also rarely described in individuals with a CDC73-related disorder. A germline CDC73 pathogenic variant has been identified in 20%-29% of individuals with parathyroid carcinoma without a known family history of CDC73-related conditions. Familial isolated hyperparathyroidism (FIHP). Characterized by primary hyperparathyroidism without other associated syndromic features. Individuals with CDC73-related FIHP tend to have a more severe clinical presentation and younger age of onset than individuals with FIHP in whom a CDC73 pathogenic variant has not been identified.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/310065">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1386327"><div><strong>Hyperparathyroidism 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1386327</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4479229</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Any familial isolated hyperparathyroidism in which the cause of the disease is a mutation in the GCM2 gene.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1386327">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_310065" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hyperparathyroidism 2 with jaw tumors</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1386327" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hyperparathyroidism 4</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_146361" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Parathyroid carcinoma</a></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/36621911">Diagnosis and management of parathyroid carcinoma: a state-of-the-art review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Roser P,
Leca BM,
Coelho C,
Schulte KM,
Gilbert J,
Drakou EE,
Kosmas C,
Ling Chuah L,
Wassati H,
Miras AD,
Crane J,
Aylwin SJB,
Grossman AB,
Dimitriadis GK</span><br />
<span class="medgenPMjournal">Endocr Relat Cancer</span>
2023 Apr 1;30(4)
Epub 2023 Mar 22
doi: 10.1530/ERC-22-0287.
<span class="bold">PMID: </span><a href="/pubmed/36621911" target="_blank">36621911</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36545746">Treatment of Hypercalcemia of Malignancy in Adults: An Endocrine Society Clinical Practice Guideline.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">El-Hajj Fuleihan G,
Clines GA,
Hu MI,
Marcocci C,
Murad MH,
Piggott T,
Van Poznak C,
Wu JY,
Drake MT</span><br />
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
2023 Feb 15;108(3):507-528.
doi: 10.1210/clinem/dgac621.
<span class="bold">PMID: </span><a href="/pubmed/36545746" target="_blank">36545746</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31826272">Diagnosis, Pathophysiology and Management of Hypercalcemia in Malignancy: A Review of the Literature.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Asonitis N,
Angelousi A,
Zafeiris C,
Lambrou GI,
Dontas I,
Kassi E</span><br />
<span class="medgenPMjournal">Horm Metab Res</span>
2019 Dec;51(12):770-778.
Epub 2019 Dec 11
doi: 10.1055/a-1049-0647.
<span class="bold">PMID: </span><a href="/pubmed/31826272" target="_blank">31826272</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22parathyroid%20carcinoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (72)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/36961765">Molecular and Clinical Spectrum of Primary Hyperparathyroidism.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Jha S,
Simonds WF</span><br />
<span class="medgenPMjournal">Endocr Rev</span>
2023 Sep 15;44(5):779-818.
doi: 10.1210/endrev/bnad009.
<span class="bold">PMID: </span><a href="/pubmed/36961765" target="_blank">36961765</a><a href="/pmc/articles/PMC10502601" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36410918">Advances in Endocrine Surgery.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lui MS,
Shirali AS,
Huang BL,
Fisher SB,
Perrier ND</span><br />
<span class="medgenPMjournal">Surg Oncol Clin N Am</span>
2023 Jan;32(1):199-220.
Epub 2022 Nov 3
doi: 10.1016/j.soc.2022.08.004.
<span class="bold">PMID: </span><a href="/pubmed/36410918" target="_blank">36410918</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26771263">Parathyroid carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Goswamy J,
Lei M,
Simo R</span><br />
<span class="medgenPMjournal">Curr Opin Otolaryngol Head Neck Surg</span>
2016 Apr;24(2):155-62.
doi: 10.1097/MOO.0000000000000234.
<span class="bold">PMID: </span><a href="/pubmed/26771263" target="_blank">26771263</a></div>
<div class="nl"><a target="_blank" href="/pubmed/20310041">Parathyroid carcinoma: a review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Owen RP,
Silver CE,
Pellitteri PK,
Shaha AR,
Devaney KO,
Werner JA,
Rinaldo A,
Ferlito A</span><br />
<span class="medgenPMjournal">Head Neck</span>
2011 Mar;33(3):429-36.
doi: 10.1002/hed.21376.
<span class="bold">PMID: </span><a href="/pubmed/20310041" target="_blank">20310041</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19172564">Parathyroid carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Thompson LD</span><br />
<span class="medgenPMjournal">Ear Nose Throat J</span>
2009 Jan;88(1):722-4.
<span class="bold">PMID: </span><a href="/pubmed/19172564" target="_blank">19172564</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Parathyroid%20carcinoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (303)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/36621911">Diagnosis and management of parathyroid carcinoma: a state-of-the-art review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Roser P,
Leca BM,
Coelho C,
Schulte KM,
Gilbert J,
Drakou EE,
Kosmas C,
Ling Chuah L,
Wassati H,
Miras AD,
Crane J,
Aylwin SJB,
Grossman AB,
Dimitriadis GK</span><br />
<span class="medgenPMjournal">Endocr Relat Cancer</span>
2023 Apr 1;30(4)
Epub 2023 Mar 22
doi: 10.1530/ERC-22-0287.
<span class="bold">PMID: </span><a href="/pubmed/36621911" target="_blank">36621911</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35175514">Overview of the 2022 WHO Classification of Parathyroid Tumors.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Erickson LA,
Mete O,
Juhlin CC,
Perren A,
Gill AJ</span><br />
<span class="medgenPMjournal">Endocr Pathol</span>
2022 Mar;33(1):64-89.
Epub 2022 Feb 17
doi: 10.1007/s12022-022-09709-1.
<span class="bold">PMID: </span><a href="/pubmed/35175514" target="_blank">35175514</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31672291">Parathyroid Pathology.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Guilmette J,
Sadow PM</span><br />
<span class="medgenPMjournal">Surg Pathol Clin</span>
2019 Dec;12(4):1007-1019.
Epub 2019 Sep 27
doi: 10.1016/j.path.2019.08.006.
<span class="bold">PMID: </span><a href="/pubmed/31672291" target="_blank">31672291</a><a href="/pmc/articles/PMC7395581" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30641523">Parathyroid Carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cetani F,
Pardi E,
Marcocci C</span><br />
<span class="medgenPMjournal">Front Horm Res</span>
2019;51:63-76.
Epub 2018 Nov 19
doi: 10.1159/000491039.
<span class="bold">PMID: </span><a href="/pubmed/30641523" target="_blank">30641523</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19016595">Parathyroid carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Marcocci C,
Cetani F,
Rubin MR,
Silverberg SJ,
Pinchera A,
Bilezikian JP</span><br />
<span class="medgenPMjournal">J Bone Miner Res</span>
2008 Dec;23(12):1869-80.
doi: 10.1359/jbmr.081018.
<span class="bold">PMID: </span><a href="/pubmed/19016595" target="_blank">19016595</a><a href="/pmc/articles/PMC3276344" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Parathyroid%20carcinoma%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (655)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/36961765">Molecular and Clinical Spectrum of Primary Hyperparathyroidism.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Jha S,
Simonds WF</span><br />
<span class="medgenPMjournal">Endocr Rev</span>
2023 Sep 15;44(5):779-818.
doi: 10.1210/endrev/bnad009.
<span class="bold">PMID: </span><a href="/pubmed/36961765" target="_blank">36961765</a><a href="/pmc/articles/PMC10502601" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36545746">Treatment of Hypercalcemia of Malignancy in Adults: An Endocrine Society Clinical Practice Guideline.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">El-Hajj Fuleihan G,
Clines GA,
Hu MI,
Marcocci C,
Murad MH,
Piggott T,
Van Poznak C,
Wu JY,
Drake MT</span><br />
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
2023 Feb 15;108(3):507-528.
doi: 10.1210/clinem/dgac621.
<span class="bold">PMID: </span><a href="/pubmed/36545746" target="_blank">36545746</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27532368">The American Association of Endocrine Surgeons Guidelines for Definitive Management of Primary Hyperparathyroidism.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wilhelm SM,
Wang TS,
Ruan DT,
Lee JA,
Asa SL,
Duh QY,
Doherty GM,
Herrera MF,
Pasieka JL,
Perrier ND,
Silverberg SJ,
Solórzano CC,
Sturgeon C,
Tublin ME,
Udelsman R,
Carty SE</span><br />
<span class="medgenPMjournal">JAMA Surg</span>
2016 Oct 1;151(10):959-968.
doi: 10.1001/jamasurg.2016.2310.
<span class="bold">PMID: </span><a href="/pubmed/27532368" target="_blank">27532368</a></div>
<div class="nl"><a target="_blank" href="/pubmed/15631545">Cinacalcet hydrochloride.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Barman Balfour JA,
Scott LJ</span><br />
<span class="medgenPMjournal">Drugs</span>
2005;65(2):271-81.
doi: 10.2165/00003495-200565020-00007.
<span class="bold">PMID: </span><a href="/pubmed/15631545" target="_blank">15631545</a></div>
<div class="nl"><a target="_blank" href="/pubmed/12057115">Parathyroid carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kebebew E</span><br />
<span class="medgenPMjournal">Curr Treat Options Oncol</span>
2001 Aug;2(4):347-54.
doi: 10.1007/s11864-001-0028-2.
<span class="bold">PMID: </span><a href="/pubmed/12057115" target="_blank">12057115</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Parathyroid%20carcinoma%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (151)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/31826272">Diagnosis, Pathophysiology and Management of Hypercalcemia in Malignancy: A Review of the Literature.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Asonitis N,
Angelousi A,
Zafeiris C,
Lambrou GI,
Dontas I,
Kassi E</span><br />
<span class="medgenPMjournal">Horm Metab Res</span>
2019 Dec;51(12):770-778.
Epub 2019 Dec 11
doi: 10.1055/a-1049-0647.
<span class="bold">PMID: </span><a href="/pubmed/31826272" target="_blank">31826272</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26771263">Parathyroid carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Goswamy J,
Lei M,
Simo R</span><br />
<span class="medgenPMjournal">Curr Opin Otolaryngol Head Neck Surg</span>
2016 Apr;24(2):155-62.
doi: 10.1097/MOO.0000000000000234.
<span class="bold">PMID: </span><a href="/pubmed/26771263" target="_blank">26771263</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24742584">Parathyroid carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Al-Kurd A,
Mekel M,
Mazeh H</span><br />
<span class="medgenPMjournal">Surg Oncol</span>
2014 Jun;23(2):107-14.
Epub 2014 Apr 3
doi: 10.1016/j.suronc.2014.03.005.
<span class="bold">PMID: </span><a href="/pubmed/24742584" target="_blank">24742584</a></div>
<div class="nl"><a target="_blank" href="/pubmed/20310041">Parathyroid carcinoma: a review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Owen RP,
Silver CE,
Pellitteri PK,
Shaha AR,
Devaney KO,
Werner JA,
Rinaldo A,
Ferlito A</span><br />
<span class="medgenPMjournal">Head Neck</span>
2011 Mar;33(3):429-36.
doi: 10.1002/hed.21376.
<span class="bold">PMID: </span><a href="/pubmed/20310041" target="_blank">20310041</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19172564">Parathyroid carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Thompson LD</span><br />
<span class="medgenPMjournal">Ear Nose Throat J</span>
2009 Jan;88(1):722-4.
<span class="bold">PMID: </span><a href="/pubmed/19172564" target="_blank">19172564</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Parathyroid%20carcinoma%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (322)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/36621911">Diagnosis and management of parathyroid carcinoma: a state-of-the-art review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Roser P,
Leca BM,
Coelho C,
Schulte KM,
Gilbert J,
Drakou EE,
Kosmas C,
Ling Chuah L,
Wassati H,
Miras AD,
Crane J,
Aylwin SJB,
Grossman AB,
Dimitriadis GK</span><br />
<span class="medgenPMjournal">Endocr Relat Cancer</span>
2023 Apr 1;30(4)
Epub 2023 Mar 22
doi: 10.1530/ERC-22-0287.
<span class="bold">PMID: </span><a href="/pubmed/36621911" target="_blank">36621911</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36054175">Surgical Aspects of Primary Hyperparathyroidism.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Perrier N,
Lang BH,
Farias LCB,
Poch LL,
Sywak M,
Almquist M,
Vriens MR,
Yeh MW,
Shariq O,
Duh QY,
Yeh R,
Vu T,
LiVolsi V,
Sitges-Serra A</span><br />
<span class="medgenPMjournal">J Bone Miner Res</span>
2022 Nov;37(11):2373-2390.
Epub 2022 Oct 17
doi: 10.1002/jbmr.4689.
<span class="bold">PMID: </span><a href="/pubmed/36054175" target="_blank">36054175</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30551989">Parathyroid carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Salcuni AS,
Cetani F,
Guarnieri V,
Nicastro V,
Romagnoli E,
de Martino D,
Scillitani A,
Cole DEC</span><br />
<span class="medgenPMjournal">Best Pract Res Clin Endocrinol Metab</span>
2018 Dec;32(6):877-889.
Epub 2018 Dec 1
doi: 10.1016/j.beem.2018.11.002.
<span class="bold">PMID: </span><a href="/pubmed/30551989" target="_blank">30551989</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27532368">The American Association of Endocrine Surgeons Guidelines for Definitive Management of Primary Hyperparathyroidism.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wilhelm SM,
Wang TS,
Ruan DT,
Lee JA,
Asa SL,
Duh QY,
Doherty GM,
Herrera MF,
Pasieka JL,
Perrier ND,
Silverberg SJ,
Solórzano CC,
Sturgeon C,
Tublin ME,
Udelsman R,
Carty SE</span><br />
<span class="medgenPMjournal">JAMA Surg</span>
2016 Oct 1;151(10):959-968.
doi: 10.1001/jamasurg.2016.2310.
<span class="bold">PMID: </span><a href="/pubmed/27532368" target="_blank">27532368</a></div>
<div class="nl"><a target="_blank" href="/pubmed/5691200">Tertiary hyperparathyroidism.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Davies DR,
Dent CE,
Watson L</span><br />
<span class="medgenPMjournal">Br Med J</span>
1968 Aug 17;3(5615):395-9.
doi: 10.1136/bmj.3.5615.395.
<span class="bold">PMID: </span><a href="/pubmed/5691200" target="_blank">5691200</a><a href="/pmc/articles/PMC1986316" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Parathyroid%20carcinoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (207)</a></div></div>
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<div class="nl"><a target="_blank" href="/pubmed/36989753">Parathyroid carcinoma: Current management and outcomes - A systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">McInerney NJ,
Moran T,
O'Duffy F</span><br />
<span class="medgenPMjournal">Am J Otolaryngol</span>
2023 Jul-Aug;44(4):103843.
Epub 2023 Mar 23
doi: 10.1016/j.amjoto.2023.103843.
<span class="bold">PMID: </span><a href="/pubmed/36989753" target="_blank">36989753</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36621911">Diagnosis and management of parathyroid carcinoma: a state-of-the-art review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Roser P,
Leca BM,
Coelho C,
Schulte KM,
Gilbert J,
Drakou EE,
Kosmas C,
Ling Chuah L,
Wassati H,
Miras AD,
Crane J,
Aylwin SJB,
Grossman AB,
Dimitriadis GK</span><br />
<span class="medgenPMjournal">Endocr Relat Cancer</span>
2023 Apr 1;30(4)
Epub 2023 Mar 22
doi: 10.1530/ERC-22-0287.
<span class="bold">PMID: </span><a href="/pubmed/36621911" target="_blank">36621911</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36545746">Treatment of Hypercalcemia of Malignancy in Adults: An Endocrine Society Clinical Practice Guideline.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">El-Hajj Fuleihan G,
Clines GA,
Hu MI,
Marcocci C,
Murad MH,
Piggott T,
Van Poznak C,
Wu JY,
Drake MT</span><br />
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
2023 Feb 15;108(3):507-528.
doi: 10.1210/clinem/dgac621.
<span class="bold">PMID: </span><a href="/pubmed/36545746" target="_blank">36545746</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34975762">Case Report and Systematic Review: Sarcomatoid Parathyroid Carcinoma-A Rare, Highly Malignant Subtype.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yu Y,
Wang Y,
Wu Q,
Zhao X,
Liu D,
Zhao Y,
Li Y,
Wang G,
Xu J,
Chen J,
Zhang N,
Tian X</span><br />
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
2021;12:793718.
Epub 2021 Dec 15
doi: 10.3389/fendo.2021.793718.
<span class="bold">PMID: </span><a href="/pubmed/34975762" target="_blank">34975762</a><a href="/pmc/articles/PMC8719313" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33642204">Parathyroid cancer: A systematic review of diagnostic biomarkers.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Davies MP,
John Evans TW,
Tahir F,
Balasubramanian SP</span><br />
<span class="medgenPMjournal">Surgeon</span>
2021 Dec;19(6):e536-e548.
Epub 2021 Feb 26
doi: 10.1016/j.surge.2021.01.011.
<span class="bold">PMID: </span><a href="/pubmed/33642204" target="_blank">33642204</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Parathyroid%20carcinoma%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (14)</a></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul id="my-toc"></ul></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0687150%5bDISCUI%5d&amp;filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (24)</a></li>
<li><a href="/gtr/tests?term=C0687150%5bDISCUI%5d&amp;filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (2)</a></li>
<li><a href="/gtr/tests?term=C0687150%5bDISCUI%5d&amp;filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (26)</a></li>
<li><a href="/gtr/tests?term=C0687150%5bDISCUI%5d&amp;filter=method%3A2%5F19" target="_blank">Targeted variant analysis (5)</a></li>
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0687150%5bDISCUI%5d" target="_blank">See all (30)</a></total></li>
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<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&amp;start=1&amp;limit=10&amp;sort=score%20desc&amp;field=number&amp;search=608266" target="_blank">OMIM</a></li><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=143" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Parathyroid%20carcinoma" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22parathyroid%20carcinoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Parathyroid%20carcinoma%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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