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1104 lines
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167 KiB
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<!--
|
||
UID=146260
|
||
ConceptID=C0678222
|
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-->
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||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Breast carcinoma</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>146260</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0678222</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Carcinoma of breast</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>CA - Carcinoma of breast (254838004); Carcinoma of breast (254838004)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0003002">HP:0003002</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0004989" target="_blank">MONDO:0004989</a></td></tr>
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</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">The presence of a carcinoma of the breast. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0678222[DISCUI]&test_type=Clinical" ref="ncbi_uid=146260">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=146260" ref="ncbi_uid=146260">V</a></span></span><span class="TLline">Breast carcinoma</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/871338" ref="tree=MeSH" title="MedGen record for Abnormality of the breast">Abnormality of the breast</a></span><ul><li><span class="TLline"><a href="/medgen/1627648" ref="tree=MeSH" title="MedGen record for Abnormal breast morphology">Abnormal breast morphology</a></span><ul><li><span class="TLline"><a href="/medgen/264172" ref="tree=MeSH" title="MedGen record for Breast neoplasm">Breast neoplasm</a></span><ul><li><span class="matched_ds">Breast carcinoma</span><ul><li><span class="TLline"><a href="/medgen/128977" ref="tree=MeSH" title="MedGen record for Bilateral breast carcinoma">Bilateral breast carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/476342" ref="tree=MeSH" title="MedGen record for Contralateral Breast Carcinoma">Contralateral Breast Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/271163" ref="tree=MeSH" title="MedGen record for Synchronous bilateral breast carcinoma">Synchronous bilateral breast carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/167809" ref="tree=MeSH" title="MedGen record for Breast adenocarcinoma">Breast adenocarcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/272988" ref="tree=MeSH" title="MedGen record for Acinic cell breast carcinoma">Acinic cell breast carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1650485" ref="tree=MeSH" title="MedGen record for Recurrent Breast Acinic Cell Carcinoma">Recurrent Breast Acinic Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/267902" ref="tree=MeSH" title="MedGen record for Breast Adenocarcinoma with Spindle Cell Metaplasia">Breast Adenocarcinoma with Spindle Cell Metaplasia</a></span></li><li><span class="TLline"><a href="/medgen/231960" ref="tree=MeSH" title="MedGen record for Breast Adenocarcinoma with Squamous Metaplasia">Breast Adenocarcinoma with Squamous Metaplasia</a></span><ul><li><span class="TLline"><a href="/medgen/232437" ref="tree=MeSH" title="MedGen record for Breast Ductal Carcinoma with Squamous Metaplasia">Breast Ductal Carcinoma with Squamous Metaplasia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/272319" ref="tree=MeSH" title="MedGen record for Breast apocrine carcinoma">Breast apocrine carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/231073" ref="tree=MeSH" title="MedGen record for Breast apocrine carcinoma in situ">Breast apocrine carcinoma in situ</a></span></li><li><span class="TLline"><a href="/medgen/232670" ref="tree=MeSH" title="MedGen record for Invasive Breast Apocrine Carcinoma">Invasive Breast Apocrine Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/770984" ref="tree=MeSH" title="MedGen record for Breast carcinoma by gene expression profile">Breast carcinoma by gene expression profile</a></span><ul><li><span class="TLline"><a href="/medgen/770987" ref="tree=MeSH" title="MedGen record for Basal-like breast carcinoma">Basal-like breast carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/743175" ref="tree=MeSH" title="MedGen record for HER2 positive breast carcinoma">HER2 positive breast carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/770985" ref="tree=MeSH" title="MedGen record for Luminal A breast carcinoma">Luminal A breast carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/770986" ref="tree=MeSH" title="MedGen record for Luminal B breast carcinoma">Luminal B breast carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/771111" ref="tree=MeSH" title="MedGen record for Normal breast-like subtype of breast carcinoma">Normal breast-like subtype of breast carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1649548" ref="tree=MeSH" title="MedGen record for Triple-negative breast carcinoma">Triple-negative breast carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/315942" ref="tree=MeSH" title="MedGen record for Breast ductal adenocarcinoma">Breast ductal adenocarcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/765" ref="tree=MeSH" title="MedGen record for Ductal carcinoma in situ">Ductal carcinoma in situ</a></span></li><li><span class="TLline"><a href="/medgen/395080" ref="tree=MeSH" title="MedGen record for Metastatic Breast Ductal Carcinoma">Metastatic Breast Ductal Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/64634" ref="tree=MeSH" title="MedGen record for Breast lobular carcinoma">Breast lobular carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/75994" ref="tree=MeSH" title="MedGen record for Invasive lobular breast carcinoma">Invasive lobular breast carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/79007" ref="tree=MeSH" title="MedGen record for Lobular breast carcinoma in situ">Lobular breast carcinoma in situ</a></span></li><li><span class="TLline"><a href="/medgen/437465" ref="tree=MeSH" title="MedGen record for Metastatic Breast Lobular Carcinoma">Metastatic Breast Lobular Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1652341" ref="tree=MeSH" title="MedGen record for Recurrent Lobular Breast Carcinoma">Recurrent Lobular Breast Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/235337" ref="tree=MeSH" title="MedGen record for Breast mucinous carcinoma">Breast mucinous carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/307307" ref="tree=MeSH" title="MedGen record for Breast columnar cell mucinous carcinoma">Breast columnar cell mucinous carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/267769" ref="tree=MeSH" title="MedGen record for Breast mucinous cystadenocarcinoma">Breast mucinous cystadenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/818226" ref="tree=MeSH" title="MedGen record for Breast papillary carcinoma">Breast papillary carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/87227" ref="tree=MeSH" title="MedGen record for Breast Papillary Ductal Carcinoma In Situ">Breast Papillary Ductal Carcinoma In Situ</a></span></li><li><span class="TLline"><a href="/medgen/1788984" ref="tree=MeSH" title="MedGen record for Encapsulated Breast Papillary Carcinoma">Encapsulated Breast Papillary Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/233581" ref="tree=MeSH" title="MedGen record for Invasive Breast Papillary Carcinoma">Invasive Breast Papillary Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/236831" ref="tree=MeSH" title="MedGen record for Solid papillary breast carcinoma">Solid papillary breast carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1792206" ref="tree=MeSH" title="MedGen record for HER2-Low Breast Carcinoma">HER2-Low Breast Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1794008" ref="tree=MeSH" title="MedGen record for Metastatic HER2-Low Breast Carcinoma">Metastatic HER2-Low Breast Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1714400" ref="tree=MeSH" title="MedGen record for HER2-Negative Breast Carcinoma">HER2-Negative Breast Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1709546" ref="tree=MeSH" title="MedGen record for Metastatic HER2-Negative Breast Carcinoma">Metastatic HER2-Negative Breast Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1709081" ref="tree=MeSH" title="MedGen record for Recurrent HER2-Negative Breast Carcinoma">Recurrent HER2-Negative Breast Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1715671" ref="tree=MeSH" title="MedGen record for Refractory HER2-Negative Breast Carcinoma">Refractory HER2-Negative Breast Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1713331" ref="tree=MeSH" title="MedGen record for Hormone Receptor-Negative Breast Carcinoma">Hormone Receptor-Negative Breast Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1670518" ref="tree=MeSH" title="MedGen record for Hormone Receptor-Positive Breast Carcinoma">Hormone Receptor-Positive Breast Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1650178" ref="tree=MeSH" title="MedGen record for Refractory Hormone Receptor-Positive Breast Carcinoma">Refractory Hormone Receptor-Positive Breast Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1631521" ref="tree=MeSH" title="MedGen record for Hormone-resistant breast carcinoma">Hormone-resistant breast carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/75841" ref="tree=MeSH" title="MedGen record for Inflammatory breast carcinoma">Inflammatory breast carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1793703" ref="tree=MeSH" title="MedGen record for Metastatic Breast Inflammatory Carcinoma">Metastatic Breast Inflammatory Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/163436" ref="tree=MeSH" title="MedGen record for Recurrent Breast Inflammatory Carcinoma">Recurrent Breast Inflammatory Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1702632" ref="tree=MeSH" title="MedGen record for Unresectable Breast Inflammatory Carcinoma">Unresectable Breast Inflammatory Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/233580" ref="tree=MeSH" title="MedGen record for Invasive Breast Cribriform Carcinoma">Invasive Breast Cribriform Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/230969" ref="tree=MeSH" title="MedGen record for Invasive tubular breast carcinoma">Invasive tubular breast carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/18263" ref="tree=MeSH" title="MedGen record for Mammary Paget disease">Mammary Paget disease</a></span><ul><li><span class="TLline"><a href="/medgen/569658" ref="tree=MeSH" title="MedGen record for Breast Paget Disease with Invasive Ductal Carcinoma">Breast Paget Disease with Invasive Ductal Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/311101" ref="tree=MeSH" title="MedGen record for Breast Paget Disease without Invasive Carcinoma">Breast Paget Disease without Invasive Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/352830" ref="tree=MeSH" title="MedGen record for Paget disease of the nipple">Paget disease of the nipple</a></span></li><li><span class="TLline"><a href="/medgen/1667595" ref="tree=MeSH" title="MedGen record for Recurrent Breast Paget Disease">Recurrent Breast Paget Disease</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1712425" ref="tree=MeSH" title="MedGen record for Metastatic Breast Adenocarcinoma">Metastatic Breast Adenocarcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1719544" ref="tree=MeSH" title="MedGen record for Advanced Breast Adenocarcinoma">Advanced Breast Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1714254" ref="tree=MeSH" title="MedGen record for Locally Advanced Breast Adenocarcinoma">Locally Advanced Breast Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/233187" ref="tree=MeSH" title="MedGen record for Metastatic Breast Signet Ring Cell Carcinoma">Metastatic Breast Signet Ring Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1793161" ref="tree=MeSH" title="MedGen record for Metastatic HER2-Positive Breast Carcinoma">Metastatic HER2-Positive Breast Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1654154" ref="tree=MeSH" title="MedGen record for Metastatic Triple-Negative Breast Carcinoma">Metastatic Triple-Negative Breast Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1779609" ref="tree=MeSH" title="MedGen record for Mixed lobular and ductal breast carcinoma">Mixed lobular and ductal breast carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1786106" ref="tree=MeSH" title="MedGen record for Breast Ductal Carcinoma In Situ and Lobular Carcinoma">Breast Ductal Carcinoma In Situ and Lobular Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/235231" ref="tree=MeSH" title="MedGen record for Invasive ductal and lobular carcinoma">Invasive ductal and lobular carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1778672" ref="tree=MeSH" title="MedGen record for Recurrent Breast Adenocarcinoma">Recurrent Breast Adenocarcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1669829" ref="tree=MeSH" title="MedGen record for Recurrent Invasive Breast Carcinoma of No Special Type">Recurrent Invasive Breast Carcinoma of No Special Type</a></span></li><li><span class="TLline"><a href="/medgen/1753071" ref="tree=MeSH" title="MedGen record for Recurrent Triple-Negative Breast Carcinoma">Recurrent Triple-Negative Breast Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1715668" ref="tree=MeSH" title="MedGen record for Refractory Breast Adenocarcinoma">Refractory Breast Adenocarcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1711485" ref="tree=MeSH" title="MedGen record for Refractory Triple-Negative Breast Carcinoma">Refractory Triple-Negative Breast Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/236816" ref="tree=MeSH" title="MedGen record for Signet ring cell breast carcinoma">Signet ring cell breast carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/364344" ref="tree=MeSH" title="MedGen record for Invasive Breast Lobular Carcinoma, Signet Ring Variant">Invasive Breast Lobular Carcinoma, Signet Ring Variant</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/455939" ref="tree=MeSH" title="MedGen record for Breast Cancer by AJCC v6 Stage">Breast Cancer by AJCC v6 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1614733" ref="tree=MeSH" title="MedGen record for Stage 0 Breast Cancer AJCC v6 and v7">Stage 0 Breast Cancer AJCC v6 and v7</a></span><ul><li><span class="TLline"><a href="/medgen/83137" ref="tree=MeSH" title="MedGen record for Ductal breast carcinoma in situ and lobular carcinoma in situ">Ductal breast carcinoma in situ and lobular carcinoma in situ</a></span></li><li><span class="TLline"><a href="/medgen/673174" ref="tree=MeSH" title="MedGen record for Female Breast Carcinoma In Situ">Female Breast Carcinoma In Situ</a></span></li><li><span class="TLline"><a href="/medgen/673213" ref="tree=MeSH" title="MedGen record for Male Breast Carcinoma In Situ">Male Breast Carcinoma In Situ</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/75824" ref="tree=MeSH" title="MedGen record for Stage I Breast Cancer AJCC v6">Stage I Breast Cancer AJCC v6</a></span></li><li><span class="TLline"><a href="/medgen/1625688" ref="tree=MeSH" title="MedGen record for Stage II Breast Cancer AJCC v6 and v7">Stage II Breast Cancer AJCC v6 and v7</a></span><ul><li><span class="TLline"><a href="/medgen/236867" ref="tree=MeSH" title="MedGen record for Stage IIA Breast Cancer AJCC v6 and v7">Stage IIA Breast Cancer AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/236874" ref="tree=MeSH" title="MedGen record for Stage IIB Breast Cancer AJCC v6 and v7">Stage IIB Breast Cancer AJCC v6 and v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/75825" ref="tree=MeSH" title="MedGen record for Stage III Breast Cancer AJCC v6">Stage III Breast Cancer AJCC v6</a></span><ul><li><span class="TLline"><a href="/medgen/453227" ref="tree=MeSH" title="MedGen record for Stage IIIC Breast Cancer AJCC v6">Stage IIIC Breast Cancer AJCC v6</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1615085" ref="tree=MeSH" title="MedGen record for Stage IV Breast Cancer AJCC v6 and v7">Stage IV Breast Cancer AJCC v6 and v7</a></span><ul><li><span class="TLline"><a href="/medgen/163437" ref="tree=MeSH" title="MedGen record for Stage IV Breast Inflammatory Carcinoma">Stage IV Breast Inflammatory Carcinoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/456321" ref="tree=MeSH" title="MedGen record for Breast Cancer by AJCC v7 Stage">Breast Cancer by AJCC v7 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/453226" ref="tree=MeSH" title="MedGen record for Stage I Breast Cancer AJCC v7">Stage I Breast Cancer AJCC v7</a></span><ul><li><span class="TLline"><a href="/medgen/443619" ref="tree=MeSH" title="MedGen record for Stage IA Breast Cancer AJCC v7">Stage IA Breast Cancer AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/415710" ref="tree=MeSH" title="MedGen record for Stage IB Breast Cancer AJCC v7">Stage IB Breast Cancer AJCC v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/459999" ref="tree=MeSH" title="MedGen record for Stage III Breast Cancer AJCC v7">Stage III Breast Cancer AJCC v7</a></span><ul><li><span class="TLline"><a href="/medgen/124464" ref="tree=MeSH" title="MedGen record for Stage IIIA Breast Cancer AJCC v7">Stage IIIA Breast Cancer AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/124468" ref="tree=MeSH" title="MedGen record for Stage IIIB Breast Cancer AJCC v7">Stage IIIB Breast Cancer AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/453363" ref="tree=MeSH" title="MedGen record for Stage IIIC Breast Cancer AJCC v7">Stage IIIC Breast Cancer AJCC v7</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1615855" ref="tree=MeSH" title="MedGen record for Breast Cancer by AJCC v8 Stage">Breast Cancer by AJCC v8 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1612798" ref="tree=MeSH" title="MedGen record for Breast Cancer by AJCC v8 Anatomic Stage">Breast Cancer by AJCC v8 Anatomic Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1625854" ref="tree=MeSH" title="MedGen record for Anatomic Stage 0 Breast Cancer AJCC v8">Anatomic Stage 0 Breast Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1617436" ref="tree=MeSH" title="MedGen record for Anatomic Stage I Breast Cancer AJCC v8">Anatomic Stage I Breast Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1627542" ref="tree=MeSH" title="MedGen record for Anatomic Stage II Breast Cancer AJCC v8">Anatomic Stage II Breast Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1612815" ref="tree=MeSH" title="MedGen record for Anatomic Stage III Breast Cancer AJCC v8">Anatomic Stage III Breast Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1618874" ref="tree=MeSH" title="MedGen record for Anatomic Stage IV Breast Cancer AJCC v8">Anatomic Stage IV Breast Cancer AJCC v8</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1615156" ref="tree=MeSH" title="MedGen record for Breast Cancer by AJCC v8 Prognostic Stage">Breast Cancer by AJCC v8 Prognostic Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1619631" ref="tree=MeSH" title="MedGen record for Prognostic Stage 0 Breast Cancer AJCC v8">Prognostic Stage 0 Breast Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1625952" ref="tree=MeSH" title="MedGen record for Prognostic Stage I Breast Cancer AJCC v8">Prognostic Stage I Breast Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1624844" ref="tree=MeSH" title="MedGen record for Prognostic Stage II Breast Cancer AJCC v8">Prognostic Stage II Breast Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1622234" ref="tree=MeSH" title="MedGen record for Prognostic Stage III Breast Cancer AJCC v8">Prognostic Stage III Breast Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1614927" ref="tree=MeSH" title="MedGen record for Prognostic Stage IV Breast Cancer AJCC v8">Prognostic Stage IV Breast Cancer AJCC v8</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/68650" ref="tree=MeSH" title="MedGen record for Carcinoma of male breast">Carcinoma of male breast</a></span><ul><li><span class="TLline"><a href="/medgen/232280" ref="tree=MeSH" title="MedGen record for Hereditary Male Breast Carcinoma">Hereditary Male Breast Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1788755" ref="tree=MeSH" title="MedGen record for Invasive Male Breast Carcinoma">Invasive Male Breast Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/856665" ref="tree=MeSH" title="MedGen record for Childhood Breast Carcinoma">Childhood Breast Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/458891" ref="tree=MeSH" title="MedGen record for Early Stage Breast Carcinoma">Early Stage Breast Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1793278" ref="tree=MeSH" title="MedGen record for Early Stage Triple-Negative Breast Carcinoma">Early Stage Triple-Negative Breast Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/87542" ref="tree=MeSH" title="MedGen record for Familial cancer of breast">Familial cancer of breast</a></span><ul><li><span class="TLline"><a href="/medgen/439" ref="tree=MeSH" title="MedGen record for Ataxia-telangiectasia syndrome">Ataxia-telangiectasia syndrome</a></span></li><li><span class="TLline"><a href="/medgen/1710970" ref="tree=MeSH" title="MedGen record for BRCA-Associated Breast Carcinoma">BRCA-Associated Breast Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1697431" ref="tree=MeSH" title="MedGen record for Metastatic BRCA-Associated Breast Carcinoma">Metastatic BRCA-Associated Breast Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/865388" ref="tree=MeSH" title="MedGen record for Breast cancer, early-onset">Breast cancer, early-onset</a></span></li><li><span class="TLline"><a href="/medgen/350535" ref="tree=MeSH" title="MedGen record for Breast cancer, familial male">Breast cancer, familial male</a></span></li><li><span class="TLline"><a href="/medgen/854012" ref="tree=MeSH" title="MedGen record for Breast cancer, susceptibility to">Breast cancer, susceptibility to</a></span></li><li><span class="TLline"><a href="/medgen/323015" ref="tree=MeSH" title="MedGen record for Fanconi anemia complementation group J">Fanconi anemia complementation group J</a></span></li><li><span class="TLline"><a href="/medgen/372133" ref="tree=MeSH" title="MedGen record for Fanconi anemia complementation group N">Fanconi anemia complementation group N</a></span></li><li><span class="TLline"><a href="/medgen/151793" ref="tree=MeSH" title="MedGen record for Hereditary breast ovarian cancer syndrome">Hereditary breast ovarian cancer syndrome</a></span><ul><li><span class="TLline"><a href="/medgen/231922" ref="tree=MeSH" title="MedGen record for BRCA1-Associated Hereditary Breast and Ovarian Cancer Syndrome">BRCA1-Associated Hereditary Breast and Ovarian Cancer Syndrome</a></span></li><li><span class="TLline"><a href="/medgen/231923" ref="tree=MeSH" title="MedGen record for BRCA2-Associated Hereditary Breast and Ovarian Cancer Syndrome">BRCA2-Associated Hereditary Breast and Ovarian Cancer Syndrome</a></span></li><li><span class="TLline"><a href="/medgen/382914" ref="tree=MeSH" title="MedGen record for Breast-ovarian cancer, familial, susceptibility to, 1">Breast-ovarian cancer, familial, susceptibility to, 1</a></span></li><li><span class="TLline"><a href="/medgen/382625" ref="tree=MeSH" title="MedGen record for Breast-ovarian cancer, familial, susceptibility to, 2">Breast-ovarian cancer, familial, susceptibility to, 2</a></span></li><li><span class="TLline"><a href="/medgen/462009" ref="tree=MeSH" title="MedGen record for Breast-ovarian cancer, familial, susceptibility to, 3">Breast-ovarian cancer, familial, susceptibility to, 3</a></span></li><li><span class="TLline"><a href="/medgen/481975" ref="tree=MeSH" title="MedGen record for Breast-ovarian cancer, familial, susceptibility to, 4">Breast-ovarian cancer, familial, susceptibility to, 4</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/272712" ref="tree=MeSH" title="MedGen record for Hereditary Female Breast Carcinoma">Hereditary Female Breast Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/88399" ref="tree=MeSH" title="MedGen record for Li-Fraumeni syndrome">Li-Fraumeni syndrome</a></span><ul><li><span class="TLline"><a href="/medgen/322930" ref="tree=MeSH" title="MedGen record for CHEK2-Associated Li-Fraumeni-Like Syndrome">CHEK2-Associated Li-Fraumeni-Like Syndrome</a></span></li><li><span class="TLline"><a href="/medgen/322656" ref="tree=MeSH" title="MedGen record for Li-Fraumeni syndrome 1">Li-Fraumeni syndrome 1</a></span></li><li><span class="TLline"><a href="/medgen/1849727" ref="tree=MeSH" title="MedGen record for Li-Fraumeni syndrome 2">Li-Fraumeni syndrome 2</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1716658" ref="tree=MeSH" title="MedGen record for PALB2-Associated Breast Carcinoma">PALB2-Associated Breast Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/18404" ref="tree=MeSH" title="MedGen record for Peutz-Jeghers syndrome">Peutz-Jeghers syndrome</a></span></li><li><span class="TLline"><a href="/medgen/368366" ref="tree=MeSH" title="MedGen record for PTEN hamartoma tumor syndrome">PTEN hamartoma tumor syndrome</a></span><ul><li><span class="TLline"><a href="/medgen/78554" ref="tree=MeSH" title="MedGen record for Bannayan-Riley-Ruvalcaba syndrome">Bannayan-Riley-Ruvalcaba syndrome</a></span></li><li><span class="TLline"><a href="/medgen/5420" ref="tree=MeSH" title="MedGen record for Cowden syndrome">Cowden syndrome</a></span></li><li><span class="TLline"><a href="/medgen/833619" ref="tree=MeSH" title="MedGen record for Cowden syndrome 1">Cowden syndrome 1</a></span></li><li><span class="TLline"><a href="/medgen/140251" ref="tree=MeSH" title="MedGen record for Lhermitte-Duclos disease">Lhermitte-Duclos disease</a></span></li><li><span class="TLline"><a href="/medgen/39008" ref="tree=MeSH" title="MedGen record for Proteus syndrome">Proteus syndrome</a></span></li><li><span class="TLline"><a href="/medgen/356222" ref="tree=MeSH" title="MedGen record for Proteus-like syndrome">Proteus-like syndrome</a></span></li><li><span class="TLline"><a href="/medgen/1637405" ref="tree=MeSH" title="MedGen record for Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome">Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/40099" ref="tree=MeSH" title="MedGen record for Female breast carcinoma">Female breast carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1781389" ref="tree=MeSH" title="MedGen record for Invasive Female Breast Carcinoma">Invasive Female Breast Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/163435" ref="tree=MeSH" title="MedGen record for Invasive breast carcinoma">Invasive breast carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/231031" ref="tree=MeSH" title="MedGen record for Adenoid cystic breast carcinoma">Adenoid cystic breast carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/273396" ref="tree=MeSH" title="MedGen record for Breast Mixed Carcinoma">Breast Mixed Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/267645" ref="tree=MeSH" title="MedGen record for Adenosquamous breast carcinoma">Adenosquamous breast carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/235230" ref="tree=MeSH" title="MedGen record for Invasive Breast Ductal Carcinoma and Invasive Lobular Carcinoma">Invasive Breast Ductal Carcinoma and Invasive Lobular Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1784659" ref="tree=MeSH" title="MedGen record for Breast Neuroendocrine Carcinoma">Breast Neuroendocrine Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/307310" ref="tree=MeSH" title="MedGen record for Breast large cell neuroendocrine carcinoma">Breast large cell neuroendocrine carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/234053" ref="tree=MeSH" title="MedGen record for Breast Small Cell Neuroendocrine Carcinoma">Breast Small Cell Neuroendocrine Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1785472" ref="tree=MeSH" title="MedGen record for Breast Polymorphous Adenocarcinoma">Breast Polymorphous Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/87226" ref="tree=MeSH" title="MedGen record for Breast secretory carcinoma">Breast secretory carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1784377" ref="tree=MeSH" title="MedGen record for Breast Tall Cell Carcinoma with Reversed Polarity">Breast Tall Cell Carcinoma with Reversed Polarity</a></span></li><li><span class="TLline"><a href="/medgen/233578" ref="tree=MeSH" title="MedGen record for Invasive Breast Carcinoma by Histologic Grade">Invasive Breast Carcinoma by Histologic Grade</a></span><ul><li><span class="TLline"><a href="/medgen/272673" ref="tree=MeSH" title="MedGen record for Grade 1 Invasive Breast Carcinoma">Grade 1 Invasive Breast Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/232247" ref="tree=MeSH" title="MedGen record for Grade 2 Invasive Breast Carcinoma">Grade 2 Invasive Breast Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/234317" ref="tree=MeSH" title="MedGen record for Grade 3 Invasive Breast Carcinoma">Grade 3 Invasive Breast Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/309375" ref="tree=MeSH" title="MedGen record for Malignant breast myoepithelioma">Malignant breast myoepithelioma</a></span></li><li><span class="TLline"><a href="/medgen/277360" ref="tree=MeSH" title="MedGen record for Metaplastic breast carcinoma">Metaplastic breast carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/307769" ref="tree=MeSH" title="MedGen record for Mixed epithelial/mesenchymal metaplastic breast carcinoma">Mixed epithelial/mesenchymal metaplastic breast carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/473642" ref="tree=MeSH" title="MedGen record for Microinvasive Breast Carcinoma">Microinvasive Breast Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/233721" ref="tree=MeSH" title="MedGen record for Mucoepidermoid breast carcinoma">Mucoepidermoid breast carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/234346" ref="tree=MeSH" title="MedGen record for Breast High Grade Mucoepidermoid Carcinoma">Breast High Grade Mucoepidermoid Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/272798" ref="tree=MeSH" title="MedGen record for Breast Low Grade Mucoepidermoid Carcinoma">Breast Low Grade Mucoepidermoid Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/233465" ref="tree=MeSH" title="MedGen record for Squamous cell breast carcinoma">Squamous cell breast carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/274268" ref="tree=MeSH" title="MedGen record for Acantholytic variant squamous cell breast carcinoma">Acantholytic variant squamous cell breast carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/274269" ref="tree=MeSH" title="MedGen record for Large cell keratinizing variant squamous cell breast carcinoma">Large cell keratinizing variant squamous cell breast carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/233188" ref="tree=MeSH" title="MedGen record for Metastatic Breast Squamous Cell Carcinoma">Metastatic Breast Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/274270" ref="tree=MeSH" title="MedGen record for Spindle cell variant squamous cell breast carcinoma">Spindle cell variant squamous cell breast carcinoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1690308" ref="tree=MeSH" title="MedGen record for Localized Breast Carcinoma">Localized Breast Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1651514" ref="tree=MeSH" title="MedGen record for Metastatic Breast Carcinoma">Metastatic Breast Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1687643" ref="tree=MeSH" title="MedGen record for Advanced Breast Carcinoma">Advanced Breast Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/272383" ref="tree=MeSH" title="MedGen record for Breast Carcinoma Metastatic in the Bone">Breast Carcinoma Metastatic in the Bone</a></span><ul><li><span class="TLline"><a href="/medgen/1650310" ref="tree=MeSH" title="MedGen record for Breast Carcinoma Metastatic in the Spine">Breast Carcinoma Metastatic in the Spine</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1612003" ref="tree=MeSH" title="MedGen record for Breast Carcinoma Metastatic in the Central Nervous System">Breast Carcinoma Metastatic in the Central Nervous System</a></span><ul><li><span class="TLline"><a href="/medgen/234049" ref="tree=MeSH" title="MedGen record for Breast Carcinoma Metastatic in the Brain">Breast Carcinoma Metastatic in the Brain</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/272384" ref="tree=MeSH" title="MedGen record for Breast Carcinoma Metastatic in the Liver">Breast Carcinoma Metastatic in the Liver</a></span></li><li><span class="TLline"><a href="/medgen/231964" ref="tree=MeSH" title="MedGen record for Breast Carcinoma Metastatic in the Lung">Breast Carcinoma Metastatic in the Lung</a></span></li><li><span class="TLline"><a href="/medgen/1659340" ref="tree=MeSH" title="MedGen record for Breast Carcinoma Metastatic in the Lymph Nodes">Breast Carcinoma Metastatic in the Lymph Nodes</a></span></li><li><span class="TLline"><a href="/medgen/1703295" ref="tree=MeSH" title="MedGen record for Locally Advanced Breast Carcinoma">Locally Advanced Breast Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1698790" ref="tree=MeSH" title="MedGen record for Locally Advanced Unresectable Breast Carcinoma">Locally Advanced Unresectable Breast Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/182595" ref="tree=MeSH" title="MedGen record for Metastatic Breast Carcinoma in the Skin">Metastatic Breast Carcinoma in the Skin</a></span></li><li><span class="TLline"><a href="/medgen/1792180" ref="tree=MeSH" title="MedGen record for Oligometastatic Breast Carcinoma">Oligometastatic Breast Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/458890" ref="tree=MeSH" title="MedGen record for Multicentric Breast Carcinoma">Multicentric Breast Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/458888" ref="tree=MeSH" title="MedGen record for Multifocal breast carcinoma">Multifocal breast carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/233756" ref="tree=MeSH" title="MedGen record for Nipple carcinoma">Nipple carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/236845" ref="tree=MeSH" title="MedGen record for Squamous Cell Carcinoma In Situ of the Nipple">Squamous Cell Carcinoma In Situ of the Nipple</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1612883" ref="tree=MeSH" title="MedGen record for Occult Breast Carcinoma">Occult Breast Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/75826" ref="tree=MeSH" title="MedGen record for Recurrent Breast Carcinoma">Recurrent Breast Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1647173" ref="tree=MeSH" title="MedGen record for Refractory Breast Carcinoma">Refractory Breast Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/233463" ref="tree=MeSH" title="MedGen record for Sporadic breast cancer">Sporadic breast cancer</a></span></li><li><span class="TLline"><a href="/medgen/328143" ref="tree=MeSH" title="MedGen record for Unilateral Breast Carcinoma">Unilateral Breast Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1702294" ref="tree=MeSH" title="MedGen record for Unresectable Breast Carcinoma">Unresectable Breast Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1718900" ref="tree=MeSH" title="MedGen record for Unresectable Triple-Negative Breast Carcinoma">Unresectable Triple-Negative Breast Carcinoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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<div class="divPopper rprt" id="rdis_18013"><div><strong>Neurofibromatosis, type 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>18013</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0027831</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">Neurofibromatosis 1 (NF1) is a multisystem disorder characterized by multiple café au lait macules, intertriginous freckling, multiple cutaneous neurofibromas, and learning disability or behavior problems. About half of people with NF1 have plexiform neurofibromas, but most are internal and not suspected clinically. Plexiform neurofibromas can cause pain, neurologic deficits, and abnormalities of involved or adjacent structures. Less common but potentially more serious manifestations include optic nerve and other central nervous system gliomas, malignant peripheral nerve sheath tumors, scoliosis, tibial dysplasia, vasculopathy, and gastrointestinal, endocrine, or pulmonary disease.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/18013">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_18404"><div><strong>Peutz-Jeghers syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>18404</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0031269</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Peutz-Jeghers syndrome (PJS) is characterized by the association of gastrointestinal (GI) polyposis, mucocutaneous pigmentation, and cancer predisposition. PJS-type hamartomatous polyps are most common in the small intestine (in order of prevalence: jejunum, ileum, and duodenum) but can also occur in the stomach, large bowel, and extraintestinal sites including the renal pelvis, bronchus, gall bladder, nasal passages, urinary bladder, and ureters. GI polyps can result in chronic bleeding, anemia, and recurrent obstruction and intussusception requiring repeated laparotomy and bowel resection. Mucocutaneous hyperpigmentation presents in childhood as dark blue to dark brown macules around the mouth, eyes, and nostrils, in the perianal area, and on the buccal mucosa. Hyperpigmented macules on the fingers are common. The macules may fade in puberty and adulthood. Recognition of the distinctive skin manifestations is important especially in individuals who have PJS as the result of a de novo pathogenic variant as these skin findings often predate GI signs and symptoms. Individuals with PJS are at increased risk for a wide variety of epithelial malignancies (colorectal, gastric, pancreatic, breast, and ovarian cancers). Females are at risk for sex cord tumors with annular tubules (SCTAT), a benign neoplasm of the ovaries, and adenoma malignum of the cervix, a rare aggressive cancer. Males occasionally develop large calcifying Sertoli cell tumors of the testes, which secrete estrogen and can lead to gynecomastia, advanced skeletal age, and ultimately short stature, if untreated.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/18404">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_64221"><div><strong>Saethre-Chotzen syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>64221</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0175699</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Classic Saethre-Chotzen syndrome (SCS) is characterized by coronal synostosis (unilateral or bilateral), facial asymmetry (particularly in individuals with unicoronal synostosis), strabismus, ptosis, and characteristic appearance of the ear (small pinna with a prominent superior and/or inferior crus). Syndactyly of digits two and three of the hand is variably present. Cognitive development is usually normal, although those with a large genomic deletion are at an increased risk for intellectual challenges. Less common manifestations of SCS include other skeletal findings (parietal foramina, vertebral segmentation defects, radioulnar synostosis, maxillary hypoplasia, ocular hypertelorism, hallux valgus, duplicated or curved distal hallux), hypertelorism, palatal anomalies, obstructive sleep apnea, increased intracranial pressure, short stature, and congenital heart malformations.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/64221">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_87542"><div><strong>Familial cancer of breast</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>87542</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0346153</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">BRCA1- and BRCA2-associated hereditary breast and ovarian cancer (HBOC) is characterized by an increased risk for female and male breast cancer, ovarian cancer (including fallopian tube and primary peritoneal cancers), and to a lesser extent other cancers such as prostate cancer, pancreatic cancer, and melanoma primarily in individuals with a BRCA2 pathogenic variant. The risk of developing an associated cancer varies depending on whether HBOC is caused by a BRCA1 or BRCA2 pathogenic variant.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/87542">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_216027"><div><strong>Ovarian cancer</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>216027</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1140680</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">Ovarian cancer, the leading cause of death from gynecologic malignancy, is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity and the rare incidence of visceral metastases (Chi et al., 2001). These typical features relate to the biology of the disease, which is a principal determinant of outcome (Auersperg et al., 2001). Epithelial ovarian cancer is the most common form and encompasses 5 major histologic subtypes: papillary serous, endometrioid, mucinous, clear cell, and transitional cell. Epithelial ovarian cancer arises as a result of genetic alterations sustained by the ovarian surface epithelium (Stany et al., 2008; Soslow, 2008).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/216027">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_231157"><div><strong>Muir-Torré syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>231157</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1321489</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">Lynch syndrome is characterized by an increased risk for colorectal cancer (CRC) and cancers of the endometrium, ovary, stomach, small bowel, urinary tract, biliary tract, brain (usually glioblastoma), skin (sebaceous adenomas, sebaceous carcinomas, and keratoacanthomas), pancreas, and prostate. Cancer risks and age of onset vary depending on the associated gene. Several other cancer types have been reported to occur in individuals with Lynch syndrome (e.g., breast, sarcomas, adrenocortical carcinoma). However, the data are not sufficient to demonstrate that the risk of developing these cancers is increased in individuals with Lynch syndrome.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/231157">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_322656"><div><strong>Li-Fraumeni syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>322656</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1835398</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome associated with high risks for a broad spectrum of cancers including early-onset cancers. Five cancer types account for the majority of LFS tumors: adrenocortical carcinomas, breast cancer, central nervous system tumors, osteosarcomas, and soft-tissue sarcomas. Other cancers associated with LFS include leukemia, colorectal cancer, stomach cancer, lung cancer, melanoma, pediatric head and neck cancers, pancreatic cancer, and prostate cancer. Cancer survivors are at increased risk for developing additional primary cancers and treatment-related secondary cancers. The lifetime risks of cancer for women and men with classic LFS are 90% and 70%, respectively, and 50% of cancers occur prior to age 40 years.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/322656">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_324868"><div><strong>Oligodontia-cancer predisposition syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>324868</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1837750</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">Oligodontia-cancer predisposition syndrome is a rare, genetic, odontologic disease characterized by congenital absence of six or more permanent teeth (excluding the third molars) in association with an increased risk for malignancies, ranging from gastrointestinal polyposis to early-onset colorectal cancer and/or breast cancer. Ectodermal dysplasia (manifesting with sparse hair and/or eyebrows) may also be associated.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/324868">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_338210"><div><strong>Desmoid disease, hereditary</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>338210</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1851124</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">APC-associated polyposis conditions include (classic or attenuated) familial adenomatous polyposis (FAP) and gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS). FAP is a colorectal cancer (CRC) predisposition syndrome that can manifest in either classic or attenuated form. Classic FAP is characterized by hundreds to thousands of adenomatous colonic polyps, beginning on average at age 16 years (range 7-36 years). For those with the classic form of FAP, 95% of individuals have polyps by age 35 years; CRC is inevitable without colectomy. The mean age of CRC diagnosis in untreated individuals is 39 years (range 34-43 years). The attenuated form is characterized by multiple colonic polyps (average of 30), more proximally located polyps, and a diagnosis of CRC at a later age than in classic FAP. For those with an attenuated form, there is a 70% lifetime risk of CRC and the mean age of diagnosis is 50-55 years. Extracolonic manifestations are variably present and include polyps of the stomach and duodenum, osteomas, dental abnormalities, congenital hypertrophy of the retinal pigment epithelium (CHRPE), benign cutaneous lesions, desmoid tumors, adrenal masses, and other associated cancers. GAPPS is characterized by proximal gastric polyposis, increased risk of gastric adenocarcinoma, and no duodenal or colonic involvement in most individuals reported.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/338210">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_400984"><div><strong>PTEN hamartoma tumor syndrome with granular cell tumor</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>400984</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1866376</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/400984">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_382625"><div><strong>Breast-ovarian cancer, familial, susceptibility to, 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>382625</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2675520</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">BRCA1- and BRCA2-associated hereditary breast and ovarian cancer (HBOC) is characterized by an increased risk for female and male breast cancer, ovarian cancer (including fallopian tube and primary peritoneal cancers), and to a lesser extent other cancers such as prostate cancer, pancreatic cancer, and melanoma primarily in individuals with a BRCA2 pathogenic variant. The risk of developing an associated cancer varies depending on whether HBOC is caused by a BRCA1 or BRCA2 pathogenic variant.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/382625">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_382914"><div><strong>Breast-ovarian cancer, familial, susceptibility to, 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>382914</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2676676</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">BRCA1- and BRCA2-associated hereditary breast and ovarian cancer (HBOC) is characterized by an increased risk for female and male breast cancer, ovarian cancer (including fallopian tube and primary peritoneal cancers), and to a lesser extent other cancers such as prostate cancer, pancreatic cancer, and melanoma primarily in individuals with a BRCA2 pathogenic variant. The risk of developing an associated cancer varies depending on whether HBOC is caused by a BRCA1 or BRCA2 pathogenic variant.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/382914">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_462009"><div><strong>Breast-ovarian cancer, familial, susceptibility to, 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462009</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3150659</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">Any hereditary breast ovarian cancer syndrome in which the cause of the disease is a mutation in the RAD51C gene.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/462009">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_482833"><div><strong>Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>482833</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3281203</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">Patients with familial cutaneous telangiectasia and cancer syndrome (FCTCS) develop cutaneous telangiectases in infancy with patchy alopecia over areas of affected skin, thinning of the lateral eyebrows, and mild dental and nail anomalies. Affected individuals are at increased risk of developing oropharyngeal cancer, and other malignancies have been reported as well (Tanaka et al., 2012).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/482833">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_767431"><div><strong>Cowden syndrome 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>767431</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3554517</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">The features of Cowden syndrome overlap with those of another disorder called Bannayan-Riley-Ruvalcaba syndrome. People with Bannayan-Riley-Ruvalcaba syndrome also develop hamartomas and other noncancerous tumors. Some people with Cowden syndrome have relatives diagnosed with Bannayan-Riley-Ruvalcaba syndrome, and other affected individuals have the characteristic features of both conditions. Based on these similarities, researchers have proposed that Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome represent a spectrum of overlapping features known as PTEN hamartoma tumor syndrome (named for the genetic cause of the conditions) instead of two distinct conditions.\n\n\n\nSome people do not meet the strict criteria for a clinical diagnosis of Cowden syndrome, but they have some of the characteristic features of the condition, particularly the cancers. These individuals are often described as having Cowden-like syndrome. Both Cowden syndrome and Cowden-like syndrome are caused by mutations in the same genes.\n\nCowden syndrome is associated with an increased risk of developing several types of cancer, particularly cancers of the breast, a gland in the lower neck called the thyroid, and the lining of the uterus (the endometrium). Other cancers that have been identified in people with Cowden syndrome include kidney cancer, colorectal cancer, and an agressive form of skin cancer called melanoma. Compared with the general population, people with Cowden syndrome develop these cancers at younger ages, often beginning in their thirties or forties. People with Cowden syndrome are also more likely to develop more than one cancer during their lifetimes compared to the general population. Other diseases of the breast, thyroid, and endometrium are also common in Cowden syndrome. Additional signs and symptoms can include an enlarged head (macrocephaly) and a rare, noncancerous brain tumor called Lhermitte-Duclos disease. A small percentage of affected individuals have delayed development, intellectual disability, or autism spectrum disorder, which can affect communication and social interaction.\n\nAlmost everyone with Cowden syndrome develops hamartomas. These growths are most commonly found on the skin and mucous membranes (such as the lining of the mouth and nose), but they can also occur in the intestine and other parts of the body. The growth of hamartomas on the skin and mucous membranes typically becomes apparent by a person's late twenties.\n\nCowden syndrome is a genetic disorder characterized by multiple noncancerous, tumor-like growths called hamartomas and an increased risk of developing certain cancers.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/767431">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_767432"><div><strong>Cowden syndrome 5</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>767432</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3554518</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">PIK3CA-related overgrowth spectrum (PROS) encompasses a range of clinical findings in which the core features are congenital or early-childhood onset of segmental/focal overgrowth with or without cellular dysplasia. Prior to the identification of PIK3CA as the causative gene, PROS was separated into distinct clinical syndromes based on the tissues and/or organs involved (e.g., MCAP [megalencephaly-capillary malformation] syndrome and CLOVES [congenital lipomatous asymmetric overgrowth of the trunk, lymphatic, capillary, venous, and combined-type vascular malformations, epidermal nevi, skeletal and spinal anomalies] syndrome). The predominant areas of overgrowth include the brain, limbs (including fingers and toes), trunk (including abdomen and chest), and face, all usually in an asymmetric distribution. Generalized brain overgrowth may be accompanied by secondary overgrowth of specific brain structures resulting in ventriculomegaly, a markedly thick corpus callosum, and cerebellar tonsillar ectopia with crowding of the posterior fossa. Vascular malformations may include capillary, venous, and less frequently, arterial or mixed (capillary-lymphatic-venous or arteriovenous) malformations. Lymphatic malformations may be in various locations (internal and/or external) and can cause various clinical issues, including swelling, pain, and occasionally localized bleeding secondary to trauma. Lipomatous overgrowth may occur ipsilateral or contralateral to a vascular malformation, if present. The degree of intellectual disability appears to be mostly related to the presence and severity of seizures, cortical dysplasia (e.g., polymicrogyria), and hydrocephalus. Many children have feeding difficulties that are often multifactorial in nature. Endocrine issues affect a small number of individuals and most commonly include hypoglycemia (largely hypoinsulinemic hypoketotic hypoglycemia), hypothyroidism, and growth hormone deficiency.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/767432">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_767433"><div><strong>Cowden syndrome 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>767433</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3554519</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">The features of Cowden syndrome overlap with those of another disorder called Bannayan-Riley-Ruvalcaba syndrome. People with Bannayan-Riley-Ruvalcaba syndrome also develop hamartomas and other noncancerous tumors. Some people with Cowden syndrome have relatives diagnosed with Bannayan-Riley-Ruvalcaba syndrome, and other affected individuals have the characteristic features of both conditions. Based on these similarities, researchers have proposed that Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome represent a spectrum of overlapping features known as PTEN hamartoma tumor syndrome (named for the genetic cause of the conditions) instead of two distinct conditions.\n\n\n\nSome people do not meet the strict criteria for a clinical diagnosis of Cowden syndrome, but they have some of the characteristic features of the condition, particularly the cancers. These individuals are often described as having Cowden-like syndrome. Both Cowden syndrome and Cowden-like syndrome are caused by mutations in the same genes.\n\nCowden syndrome is associated with an increased risk of developing several types of cancer, particularly cancers of the breast, a gland in the lower neck called the thyroid, and the lining of the uterus (the endometrium). Other cancers that have been identified in people with Cowden syndrome include kidney cancer, colorectal cancer, and an agressive form of skin cancer called melanoma. Compared with the general population, people with Cowden syndrome develop these cancers at younger ages, often beginning in their thirties or forties. People with Cowden syndrome are also more likely to develop more than one cancer during their lifetimes compared to the general population. Other diseases of the breast, thyroid, and endometrium are also common in Cowden syndrome. Additional signs and symptoms can include an enlarged head (macrocephaly) and a rare, noncancerous brain tumor called Lhermitte-Duclos disease. A small percentage of affected individuals have delayed development, intellectual disability, or autism spectrum disorder, which can affect communication and social interaction.\n\nAlmost everyone with Cowden syndrome develops hamartomas. These growths are most commonly found on the skin and mucous membranes (such as the lining of the mouth and nose), but they can also occur in the intestine and other parts of the body. The growth of hamartomas on the skin and mucous membranes typically becomes apparent by a person's late twenties.\n\nCowden syndrome is a genetic disorder characterized by multiple noncancerous, tumor-like growths called hamartomas and an increased risk of developing certain cancers.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/767433">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_902388"><div><strong>Familial adenomatous polyposis 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>902388</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4225157</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">NTHL1 tumor syndrome is characterized by an increased lifetime risk for colorectal cancer (CRC), breast cancer, and colorectal polyposis. Colorectal polyps can be adenomatous, hyperplastic, and/or sessile serrated. Duodenal polyposis has also been reported. Additional cancers reported in individuals with NTHL1 tumor syndrome include endometrial cancer, cervical cancer, urothelial carcinoma of the bladder, meningiomas, unspecified brain tumors, basal cell carcinomas, head and neck squamous cell carcinomas, and hematologic malignancies. The cumulative lifetime risk of developing extracolonic cancer by age 60 years has been estimated at 35% to 78%.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/902388">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_908796"><div><strong>Cowden syndrome 7</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>908796</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4225179</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Cowden syndrome is a genetic disorder characterized by multiple noncancerous, tumor-like growths called hamartomas and an increased risk of developing certain cancers.\n\nAlmost everyone with Cowden syndrome develops hamartomas. These growths are most commonly found on the skin and mucous membranes (such as the lining of the mouth and nose), but they can also occur in the intestine and other parts of the body. The growth of hamartomas on the skin and mucous membranes typically becomes apparent by a person's late twenties.\n\nCowden syndrome is associated with an increased risk of developing several types of cancer, particularly cancers of the breast, a gland in the lower neck called the thyroid, and the lining of the uterus (the endometrium). Other cancers that have been identified in people with Cowden syndrome include kidney cancer, colorectal cancer, and an agressive form of skin cancer called melanoma. Compared with the general population, people with Cowden syndrome develop these cancers at younger ages, often beginning in their thirties or forties. People with Cowden syndrome are also more likely to develop more than one cancer during their lifetimes compared to the general population. Other diseases of the breast, thyroid, and endometrium are also common in Cowden syndrome. Additional signs and symptoms can include an enlarged head (macrocephaly) and a rare, noncancerous brain tumor called Lhermitte-Duclos disease. A small percentage of affected individuals have delayed development, intellectual disability, or autism spectrum disorder, which can affect communication and social interaction.\n\nSome people do not meet the strict criteria for a clinical diagnosis of Cowden syndrome, but they have some of the characteristic features of the condition, particularly the cancers. These individuals are often described as having Cowden-like syndrome. Both Cowden syndrome and Cowden-like syndrome are caused by mutations in the same genes.\n\n\n\nThe features of Cowden syndrome overlap with those of another disorder called Bannayan-Riley-Ruvalcaba syndrome. People with Bannayan-Riley-Ruvalcaba syndrome also develop hamartomas and other noncancerous tumors. Some people with Cowden syndrome have relatives diagnosed with Bannayan-Riley-Ruvalcaba syndrome, and other affected individuals have the characteristic features of both conditions. Based on these similarities, researchers have proposed that Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome represent a spectrum of overlapping features known as PTEN hamartoma tumor syndrome (named for the genetic cause of the conditions) instead of two distinct conditions.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/908796">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1632414"><div><strong>Fanconi anemia, complementation group S</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1632414</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4554406</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Fanconi anemia (FA) is characterized by physical abnormalities, bone marrow failure, and increased risk for malignancy. Physical abnormalities, present in approximately 75% of affected individuals, include one or more of the following: short stature, abnormal skin pigmentation, skeletal malformations of the upper and/or lower limbs, microcephaly, and ophthalmic and genitourinary tract anomalies. Progressive bone marrow failure with pancytopenia typically presents in the first decade, often initially with thrombocytopenia or leukopenia. The incidence of acute myeloid leukemia is 13% by age 50 years. Solid tumors – particularly of the head and neck, skin, and genitourinary tract – are more common in individuals with FA.</div>
|
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<div class="spaceAbove nowrap">See: <a href="/medgen/1632414">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1841251"><div><strong>Breast-ovarian cancer, familial, susceptibility to, 5</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1841251</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5830615</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Individuals with mutation in the PALB2 gene have an increased risk of developing breast or, to a lesser degree, ovarian cancer. In addition, PALB2 variants increase susceptibility to several other cancers, e.g., male breast cancer and pancreatic cancer (PNCA3; 613348) (Rahman et al., 2007; Norquist et al., 2018; Yang et al., 2020). For a discussion of genetic heterogeneity of breast-ovarian cancer susceptibility, see BROVCA1 (604370). For general discussions of breast cancer and ovarian cancer, see 114480 and 167000, respectively. Reviews Hamdan and Nowak (2023) reviewed the structure and function of the PALB2 gene, and its role in disease, including Fanconi anemia (FANCN; 610832), pancreatic cancer (PNCA3; 613348), and breast and ovarian cancer.</div>
|
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<div class="spaceAbove nowrap">See: <a href="/medgen/1841251">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1849727"><div><strong>Li-Fraumeni syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1849727</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5882668</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Li-Fraumeni syndrome is a rare disorder that greatly increases the risk of developing several types of cancer, particularly in children and young adults.\n\nA very similar condition called Li-Fraumeni-like syndrome shares many of the features of classic Li-Fraumeni syndrome. Both conditions significantly increase the chances of developing multiple cancers beginning in childhood; however, the pattern of specific cancers seen in affected family members is different.\n\nThe cancers most often associated with Li-Fraumeni syndrome include breast cancer, a form of bone cancer called osteosarcoma, and cancers of soft tissues (such as muscle) called soft tissue sarcomas. Other cancers commonly seen in this syndrome include brain tumors, cancers of blood-forming tissues (leukemias), and a cancer called adrenocortical carcinoma that affects the outer layer of the adrenal glands (small hormone-producing glands on top of each kidney). Several other types of cancer also occur more frequently in people with Li-Fraumeni syndrome.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1849727">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_382914" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Breast-ovarian cancer, familial, susceptibility to, 1</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_382625" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Breast-ovarian cancer, familial, susceptibility to, 2</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462009" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Breast-ovarian cancer, familial, susceptibility to, 3</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1841251" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Breast-ovarian cancer, familial, susceptibility to, 5</a></div>
|
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_767431" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cowden syndrome 4</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (22)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_767432" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cowden syndrome 5</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_767433" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cowden syndrome 6</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_908796" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cowden syndrome 7</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_338210" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Desmoid disease, hereditary</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_902388" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial adenomatous polyposis 3</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_87542" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial cancer of breast</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_482833" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1632414" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Fanconi anemia, complementation group S</a></div>
|
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_322656" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Li-Fraumeni syndrome 1</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1849727" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Li-Fraumeni syndrome 2</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_231157" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Muir-Torré syndrome</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_18013" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neurofibromatosis, type 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_324868" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Oligodontia-cancer predisposition syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_216027" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ovarian cancer</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_18404" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Peutz-Jeghers syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_400984" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">PTEN hamartoma tumor syndrome with granular cell tumor</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_64221" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Saethre-Chotzen syndrome</a></div></span></div></div>
|
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</div>
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|
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<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37783319">Artificial intelligence-based risk stratification, accurate diagnosis and treatment prediction in gynecologic oncology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jiang Y,
|
||
Wang C,
|
||
Zhou S</span><br />
|
||
<span class="medgenPMjournal">Semin Cancer Biol</span>
|
||
2023 Nov;96:82-99.
|
||
Epub 2023 Sep 30
|
||
doi: 10.1016/j.semcancer.2023.09.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37783319" target="_blank">37783319</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29978332">Metastatic and triple-negative breast cancer: challenges and treatment options.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Al-Mahmood S,
|
||
Sapiezynski J,
|
||
Garbuzenko OB,
|
||
Minko T</span><br />
|
||
<span class="medgenPMjournal">Drug Deliv Transl Res</span>
|
||
2018 Oct;8(5):1483-1507.
|
||
doi: 10.1007/s13346-018-0551-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29978332" target="_blank">29978332</a><a href="/pmc/articles/PMC6133085" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23425944">Male breast cancer: risk factors, biology, diagnosis, treatment, and survivorship.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ruddy KJ,
|
||
Winer EP</span><br />
|
||
<span class="medgenPMjournal">Ann Oncol</span>
|
||
2013 Jun;24(6):1434-43.
|
||
Epub 2013 Feb 20
|
||
doi: 10.1093/annonc/mdt025.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23425944" target="_blank">23425944</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22breast%20carcinoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (782)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35567633">The morphologic spectrum of lobular carcinoma in situ (LCIS) observations on clinical significance, management implications and diagnostic pitfalls of classic, florid and pleomorphic LCIS.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brogi E</span><br />
|
||
<span class="medgenPMjournal">Virchows Arch</span>
|
||
2022 Dec;481(6):823-837.
|
||
Epub 2022 May 14
|
||
doi: 10.1007/s00428-022-03299-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35567633" target="_blank">35567633</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34286593">Evidence-Based Pragmatic Approach to the Management of Borderline or High-Risk Breast Lesions.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lamb LR,
|
||
Bahl M</span><br />
|
||
<span class="medgenPMjournal">AJR Am J Roentgenol</span>
|
||
2022 Jan;218(1):186-187.
|
||
Epub 2021 Jul 21
|
||
doi: 10.2214/AJR.21.26340.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34286593" target="_blank">34286593</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31825261">Atypical Ductal Hyperplasia and Lobular Neoplasia: Update and Easing of Guidelines.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lewin AA,
|
||
Mercado CL</span><br />
|
||
<span class="medgenPMjournal">AJR Am J Roentgenol</span>
|
||
2020 Feb;214(2):265-275.
|
||
Epub 2019 Dec 11
|
||
doi: 10.2214/AJR.19.21991.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31825261" target="_blank">31825261</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29413653">Lobular Carcinoma In Situ.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wen HY,
|
||
Brogi E</span><br />
|
||
<span class="medgenPMjournal">Surg Pathol Clin</span>
|
||
2018 Mar;11(1):123-145.
|
||
Epub 2017 Dec 8
|
||
doi: 10.1016/j.path.2017.09.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29413653" target="_blank">29413653</a><a href="/pmc/articles/PMC5841603" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24267194">Breast carcinoma: molecular profiling and updates.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bandyopadhyay S,
|
||
Ali-Fehmi R</span><br />
|
||
<span class="medgenPMjournal">Clin Lab Med</span>
|
||
2013 Dec;33(4):891-909.
|
||
doi: 10.1016/j.cll.2013.08.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24267194" target="_blank">24267194</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Breast%20carcinoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7046)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39510943">"Lobular lesions of the breast: From the classic to the variants".</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Downs E,
|
||
Gulbahce HE</span><br />
|
||
<span class="medgenPMjournal">Semin Diagn Pathol</span>
|
||
2024 Nov;41(6):258-271.
|
||
Epub 2024 Oct 28
|
||
doi: 10.1053/j.semdp.2024.10.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39510943" target="_blank">39510943</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36314440">Dimorphic Invasive Breast Carcinoma with Tubulopapillary Features.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bezić J,
|
||
Smolić J,
|
||
Bečić K</span><br />
|
||
<span class="medgenPMjournal">Int J Surg Pathol</span>
|
||
2023 Oct;31(7):1314-1316.
|
||
Epub 2022 Oct 30
|
||
doi: 10.1177/10668969221133747.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36314440" target="_blank">36314440</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35413381">TRPS1, GATA3, and SOX10 expression in triple-negative breast carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yoon EC,
|
||
Wang G,
|
||
Parkinson B,
|
||
Huo L,
|
||
Peng Y,
|
||
Wang J,
|
||
Salisbury T,
|
||
Wu Y,
|
||
Chen H,
|
||
Albarracin CT,
|
||
Resetkova E,
|
||
Middleton LP,
|
||
Krishnamurthy S,
|
||
Gan Q,
|
||
Sun H,
|
||
Huang X,
|
||
Shen T,
|
||
Chen W,
|
||
Parwani AV,
|
||
Sahin AA,
|
||
Li Z,
|
||
Ding Q</span><br />
|
||
<span class="medgenPMjournal">Hum Pathol</span>
|
||
2022 Jul;125:97-107.
|
||
Epub 2022 Apr 9
|
||
doi: 10.1016/j.humpath.2022.04.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35413381" target="_blank">35413381</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29413653">Lobular Carcinoma In Situ.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wen HY,
|
||
Brogi E</span><br />
|
||
<span class="medgenPMjournal">Surg Pathol Clin</span>
|
||
2018 Mar;11(1):123-145.
|
||
Epub 2017 Dec 8
|
||
doi: 10.1016/j.path.2017.09.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29413653" target="_blank">29413653</a><a href="/pmc/articles/PMC5841603" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/13546617">RADIOLOGICAL diagnosis of breast carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMjournal">Br Med J</span>
|
||
1958 Jun 28;1(5086):1531-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/13546617" target="_blank">13546617</a><a href="/pmc/articles/PMC2029599" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Breast%20carcinoma%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (8058)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34715356">Multiple strategies for the treatment of invasive breast carcinoma: A comprehensive prospective.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Agarwal S,
|
||
Sau S,
|
||
Iyer AK,
|
||
Dixit A,
|
||
Kashaw SK</span><br />
|
||
<span class="medgenPMjournal">Drug Discov Today</span>
|
||
2022 Feb;27(2):585-611.
|
||
Epub 2021 Oct 26
|
||
doi: 10.1016/j.drudis.2021.10.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34715356" target="_blank">34715356</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29978332">Metastatic and triple-negative breast cancer: challenges and treatment options.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Al-Mahmood S,
|
||
Sapiezynski J,
|
||
Garbuzenko OB,
|
||
Minko T</span><br />
|
||
<span class="medgenPMjournal">Drug Deliv Transl Res</span>
|
||
2018 Oct;8(5):1483-1507.
|
||
doi: 10.1007/s13346-018-0551-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29978332" target="_blank">29978332</a><a href="/pmc/articles/PMC6133085" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20193984">Male breast cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gómez-Raposo C,
|
||
Zambrana Tévar F,
|
||
Sereno Moyano M,
|
||
López Gómez M,
|
||
Casado E</span><br />
|
||
<span class="medgenPMjournal">Cancer Treat Rev</span>
|
||
2010 Oct;36(6):451-7.
|
||
Epub 2010 Mar 2
|
||
doi: 10.1016/j.ctrv.2010.02.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20193984" target="_blank">20193984</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12237930">Trastuzumab-associated cardiotoxicity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Keefe DL</span><br />
|
||
<span class="medgenPMjournal">Cancer</span>
|
||
2002 Oct 1;95(7):1592-600.
|
||
doi: 10.1002/cncr.10854.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12237930" target="_blank">12237930</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10791395">The taxanes: an update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Crown J,
|
||
O'Leary M</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2000 Apr 1;355(9210):1176-8.
|
||
doi: 10.1016/S0140-6736(00)02074-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10791395" target="_blank">10791395</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Breast%20carcinoma%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4262)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37326990">The Association Between Meningioma and Breast Cancer: A Systematic Review and Meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Degeneffe A,
|
||
De Maertelaer V,
|
||
De Witte O,
|
||
Lefranc F</span><br />
|
||
<span class="medgenPMjournal">JAMA Netw Open</span>
|
||
2023 Jun 1;6(6):e2318620.
|
||
doi: 10.1001/jamanetworkopen.2023.18620.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37326990" target="_blank">37326990</a><a href="/pmc/articles/PMC10276307" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33394683">Unexpected Death Associated With Clostridial Sepsis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Olds KL,
|
||
Gilbert JD,
|
||
Byard RW</span><br />
|
||
<span class="medgenPMjournal">Am J Forensic Med Pathol</span>
|
||
2021 Sep 1;42(3):289-291.
|
||
doi: 10.1097/PAF.0000000000000640.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33394683" target="_blank">33394683</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31456179">Breast Cancer: Current Perspectives on the Disease Status.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fahad Ullah M</span><br />
|
||
<span class="medgenPMjournal">Adv Exp Med Biol</span>
|
||
2019;1152:51-64.
|
||
doi: 10.1007/978-3-030-20301-6_4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31456179" target="_blank">31456179</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8850026">Inflammatory breast carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chambler AF,
|
||
Drew PJ,
|
||
Hill AD,
|
||
Darzi A,
|
||
Monson JR</span><br />
|
||
<span class="medgenPMjournal">Surg Oncol</span>
|
||
1995;4(5):245-54.
|
||
doi: 10.1016/s0960-7404(10)80003-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8850026" target="_blank">8850026</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2692916">Adjuvant chemotherapy and endocrine therapy for node-positive and node-negative breast carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Albain KS</span><br />
|
||
<span class="medgenPMjournal">Clin Obstet Gynecol</span>
|
||
1989 Dec;32(4):835-57.
|
||
doi: 10.1097/00003081-198912000-00026.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2692916" target="_blank">2692916</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Breast%20carcinoma%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7520)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38647255">TRPS1 is a Highly Sensitive Marker for Breast Cancer: A Tissue Microarray Study Evaluating More Than 19,000 Tumors From 152 Different Tumor Entities.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lennartz M,
|
||
Löhr N,
|
||
Höflmayer D,
|
||
Dwertmann Rico S,
|
||
von Bargen C,
|
||
Kind S,
|
||
Reiswich V,
|
||
Viehweger F,
|
||
Lutz F,
|
||
Bertram V,
|
||
Fraune C,
|
||
Gorbokon N,
|
||
Weidemann S,
|
||
Blessin NC,
|
||
Hube-Magg C,
|
||
Menz A,
|
||
Schlichter R,
|
||
Krech T,
|
||
Hinsch A,
|
||
Burandt E,
|
||
Sauter G,
|
||
Simon R,
|
||
Kluth M,
|
||
Marx AH,
|
||
Lebok P,
|
||
Dum D,
|
||
Minner S,
|
||
Jacobsen F,
|
||
Clauditz TS,
|
||
Bernreuther C,
|
||
Steurer S</span><br />
|
||
<span class="medgenPMjournal">Am J Surg Pathol</span>
|
||
2024 Jun 1;48(6):637-651.
|
||
Epub 2024 Apr 18
|
||
doi: 10.1097/PAS.0000000000002213.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38647255" target="_blank">38647255</a><a href="/pmc/articles/PMC11093513" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33011748">TRPS1: a highly sensitive and specific marker for breast carcinoma, especially for triple-negative breast cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ai D,
|
||
Yao J,
|
||
Yang F,
|
||
Huo L,
|
||
Chen H,
|
||
Lu W,
|
||
Soto LMS,
|
||
Jiang M,
|
||
Raso MG,
|
||
Wang S,
|
||
Bell D,
|
||
Liu J,
|
||
Wang H,
|
||
Tan D,
|
||
Torres-Cabala C,
|
||
Gan Q,
|
||
Wu Y,
|
||
Albarracin C,
|
||
Hung MC,
|
||
Meric-Bernstam F,
|
||
Wistuba II,
|
||
Prieto VG,
|
||
Sahin AA,
|
||
Ding Q</span><br />
|
||
<span class="medgenPMjournal">Mod Pathol</span>
|
||
2021 Apr;34(4):710-719.
|
||
Epub 2020 Oct 3
|
||
doi: 10.1038/s41379-020-00692-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33011748" target="_blank">33011748</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26339424">Clinicopathological classification and traditional prognostic indicators of breast cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Li J,
|
||
Chen Z,
|
||
Su K,
|
||
Zeng J</span><br />
|
||
<span class="medgenPMjournal">Int J Clin Exp Pathol</span>
|
||
2015;8(7):8500-5.
|
||
Epub 2015 Jul 1
|
||
<span class="bold">PMID: </span><a href="/pubmed/26339424" target="_blank">26339424</a><a href="/pmc/articles/PMC4555752" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26112812">Management of neoplastic meningitis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Roth P,
|
||
Weller M</span><br />
|
||
<span class="medgenPMjournal">Chin Clin Oncol</span>
|
||
2015 Jun;4(2):26.
|
||
doi: 10.3978/j.issn.2304-3865.2015.05.02.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26112812" target="_blank">26112812</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7976873">MR imaging of the breast: current status and future potential.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Harms SE,
|
||
Flamig DP,
|
||
Evans WP,
|
||
Harries SA,
|
||
Brown S</span><br />
|
||
<span class="medgenPMjournal">AJR Am J Roentgenol</span>
|
||
1994 Nov;163(5):1039-47.
|
||
doi: 10.2214/ajr.163.5.7976873.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7976873" target="_blank">7976873</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Breast%20carcinoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6706)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/38376268">Tumor budding in breast carcinoma: A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Buch A,
|
||
Khan U,
|
||
Rathod H,
|
||
Jain K,
|
||
Dwivedi A,
|
||
Rajesh A</span><br />
|
||
<span class="medgenPMjournal">J Cancer Res Ther</span>
|
||
2023 Oct 1;19(7):1697-1713.
|
||
Epub 2023 Apr 25
|
||
doi: 10.4103/jcrt.jcrt_188_22.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38376268" target="_blank">38376268</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37326990">The Association Between Meningioma and Breast Cancer: A Systematic Review and Meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Degeneffe A,
|
||
De Maertelaer V,
|
||
De Witte O,
|
||
Lefranc F</span><br />
|
||
<span class="medgenPMjournal">JAMA Netw Open</span>
|
||
2023 Jun 1;6(6):e2318620.
|
||
doi: 10.1001/jamanetworkopen.2023.18620.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37326990" target="_blank">37326990</a><a href="/pmc/articles/PMC10276307" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35389520">Cutaneous metastasectomy: Is there a role in breast cancer? A systematic review and overview of current treatment modalities.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Huang S,
|
||
Parekh V,
|
||
Waisman J,
|
||
Jones V,
|
||
Yuan Y,
|
||
Vora N,
|
||
Li R,
|
||
Jung J,
|
||
Kruper L,
|
||
Abdulla F,
|
||
Fong Y,
|
||
Li WY</span><br />
|
||
<span class="medgenPMjournal">J Surg Oncol</span>
|
||
2022 Aug;126(2):217-238.
|
||
Epub 2022 Apr 7
|
||
doi: 10.1002/jso.26870.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35389520" target="_blank">35389520</a><a href="/pmc/articles/PMC9545220" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26172878">Breastfeeding and maternal health outcomes: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chowdhury R,
|
||
Sinha B,
|
||
Sankar MJ,
|
||
Taneja S,
|
||
Bhandari N,
|
||
Rollins N,
|
||
Bahl R,
|
||
Martines J</span><br />
|
||
<span class="medgenPMjournal">Acta Paediatr</span>
|
||
2015 Dec;104(467):96-113.
|
||
doi: 10.1111/apa.13102.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26172878" target="_blank">26172878</a><a href="/pmc/articles/PMC4670483" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23425944">Male breast cancer: risk factors, biology, diagnosis, treatment, and survivorship.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ruddy KJ,
|
||
Winer EP</span><br />
|
||
<span class="medgenPMjournal">Ann Oncol</span>
|
||
2013 Jun;24(6):1434-43.
|
||
Epub 2013 Feb 20
|
||
doi: 10.1093/annonc/mdt025.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23425944" target="_blank">23425944</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Breast%20carcinoma%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (66)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
|
||
<div class="rightCol mgCol">
|
||
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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|
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||
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|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0678222%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (6)</a></li>
|
||
<li><a href="/gtr/tests?term=C0678222%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (7)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0678222%5bDISCUI%5d" target="_blank">See all (7)</a></total></li>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Breast%20carcinoma" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_121">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22breast%20carcinoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Breast%20carcinoma%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
|
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|
||
<div class="portlet mgSection" id="ID_116">
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<div class="portlet_content ln"><ul><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Breast%20carcinoma" target="_blank">MedlinePlus</a></li></ul></div>
|
||
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|
||
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|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
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<h3>Reviews</h3>
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<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Reviews" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter"></a>
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<ul>
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||
<li>
|
||
<a href="/pubmed/clinical?term=Breast%20carcinoma" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
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<li>
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<a href="/pubmed?term=Breast%20carcinoma%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
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|
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<!-- MedGen supplemental column ends here -->
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<h3>Related information</h3>
|
||
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||
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<div class="portlet_content DiscoveryDbLinks">
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<ul>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=146260" ref="log$=recordlinks">ClinVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0678222[DISCUI]" ref="log$=recordlinks">GTR</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0678222[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/mesh?LinkName=medgen_mesh&from_uid=146260" ref="log$=recordlinks">MeSH</a>
|
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<div class="brieflinkpop offscreen_noflow">Related Medical Subject Headings</div>
|
||
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<li class="brieflinkpopper">
|
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<a class="brieflinkpopperctrl" href="/pmc?LinkName=medgen_pmc&from_uid=146260" ref="log$=recordlinks">PMC Articles</a>
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<div class="brieflinkpop offscreen_noflow">Related information in PubMed Central Links</div>
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||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed&from_uid=146260" ref="log$=recordlinks">PubMed</a>
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<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
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||
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||
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|
||
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|
||
|
||
|
||
<div class="portlet">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
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<h3>Recent activity</h3>
|
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<div id="HTDisplay" class="">
|
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<input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Cmd" sid="1" type="hidden" />
|
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<div class="action">
|
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<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory">
|
||
Clear
|
||
</a>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOn" cmd="HTOff" href="?cmd=HTOff&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle">
|
||
Turn Off
|
||
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|
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<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" sid="2" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOff" cmd="HTOn" href="?cmd=HTOn&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle">
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Turn On
|
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|
||
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|
||
<ul id="activity">
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67d314b667c23b31e097cdac">Breast carcinoma</a>
|
||
<div class="ralinkpop offscreen_noflow">Breast carcinoma<div class="brieflinkpopdesc"></div></div>
|
||
<div class="tertiary">MedGen</div>
|
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</li>
|
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<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67d314b384f3725e591dec37">Abnormal breast morphology</a>
|
||
<div class="ralinkpop offscreen_noflow">Abnormal breast morphology<div class="brieflinkpopdesc"></div></div>
|
||
<div class="tertiary">MedGen</div>
|
||
</li>
|
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<div class="ralinkpop offscreen_noflow">NQO2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:4835</div></div>
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