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<meta name="keywords" content="C0029410, coxarthroses, coxarthrosis, degenerative joint disease of hip, disease or syndrome, hip arthrosis, hip osteoarthritis, oa - osteoarthritis of hip, osteoarthritis of hip, osteoarthritis of hips, osteoarthritis of the hip, osteoarthritis, hip, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Osteoarthritis of the hip joint." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
UID=14530
ConceptID=C0029410
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Osteoarthritis, hip</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>14530</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0029410</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
<td>Osteoarthritis of hip</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Degenerative joint disease of hip (239872002); OA - Osteoarthritis of hip (239872002); Osteoarthritis of hip (239872002)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0008843">HP:0008843</a></td></tr>
<tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0006629" target="_blank">MONDO:0006629</a></td></tr>
<tr><td>OMIM<span class="superscript">®</span>:</td>
<td><a href="https://omim.org/entry/612400" target="_blank">612400</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">Osteoarthritis of the hip joint. [from <a title="NCI Thesaurus" href="http://ncit.nci.nih.gov" class="defSource" target="_blank">NCI</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0029410[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=14530">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=14530" target="_blank" href="/omim/612400">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Osteoarthritis, hip</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/1763488" ref="tree=MeSH" title="MedGen record for Abnormality of the musculoskeletal system">Abnormality of the musculoskeletal system</a></span><ul><li><span class="TLline"><a href="/medgen/867418" ref="tree=MeSH" title="MedGen record for Abnormality of the skeletal system">Abnormality of the skeletal system</a></span><ul><li><span class="TLline"><a href="/medgen/868760" ref="tree=MeSH" title="MedGen record for Abnormal skeletal morphology">Abnormal skeletal morphology</a></span><ul><li><span class="TLline"><a href="/medgen/893053" ref="tree=MeSH" title="MedGen record for Abnormal joint morphology">Abnormal joint morphology</a></span><ul><li><span class="TLline"><a href="/medgen/2043" ref="tree=MeSH" title="MedGen record for Arthritis">Arthritis</a></span><ul><li><span class="TLline"><a href="/medgen/45244" ref="tree=MeSH" title="MedGen record for Osteoarthritis">Osteoarthritis</a></span><ul><li><span class="matched_ds">Osteoarthritis, hip</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_57704"><div><strong>Epiphysiolysis of the hip</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>57704</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0149887</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Slipped capital femoral epiphysis is defined as a posterior and inferior slippage of the proximal epiphysis of the femur onto the metaphysis (femoral neck), occurring through the physeal plate during the early adolescent growth spurt.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/57704">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_609409"><div><strong>Namaqualand hip dysplasia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>609409</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0432214</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Mild spondyloepiphyseal dysplasia due to COL2A1 mutation with early-onset osteoarthritis is a type 2 collagen-related bone disorder characterized by precocious, generalized osteoarthritis (with onset as early as childhood) and mild, dysplastic spinal changes (flattening of vertebrae, irregular endplates and wedge-shaped deformities) resulting in a mildly short trunk.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/609409">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_366028"><div><strong>Angel-shaped phalango-epiphyseal dysplasia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>366028</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1739384</a></dd><dt><span class="dotprefix"></span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
<div class="spaceAbove">A form of acromelic dysplasia with the distinctive radiological sign of angel-shaped middle phalanges, a typical metacarpophalangeal pattern profile (mainly affecting first metacarpals and middle phalanges of second, third and fifth digits which all appear short), epiphyseal changes in the hips and in some, abnormal dentition and delayed bone age. A rare disease with less than 20 cases reported in the literature, however, it is likely under diagnosed. Caused by mutations in the growth differentiation factor 5 (GDF5) gene, located on chromosome 20q11.2, encoding CDMP1 (cartilage derived morphogenetic protein). CDMP1 belongs to the TGF beta super family and plays a role in bone growth and joint morphogenesis. Transmitted as an autosomal dominant condition.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/366028">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_325376"><div><strong>Multiple epiphyseal dysplasia type 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>325376</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1838280</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Autosomal dominant multiple epiphyseal dysplasia (MED) presents in early childhood, usually with pain in the hips and/or knees after exercise. Affected children report fatigue with long-distance walking. Waddling gait may be present. Adult height is either in the lower range of normal or mildly shortened. The limbs are relatively short in comparison to the trunk. Pain and joint deformity progress, resulting in early-onset osteoarthritis, particularly of the large weight-bearing joints.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/325376">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_338604"><div><strong>Spondyloepiphyseal dysplasia tarda, autosomal recessive</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>338604</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1849054</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Autosomal recessive form of spondyloepiphyseal dysplasia tarda.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/338604">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_343940"><div><strong>Vitreoretinopathy with phalangeal epiphyseal dysplasia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>343940</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1852989</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Vitreoretinopathy with phalangeal epiphyseal dysplasia (VPED) is an autosomal dominant disorder characterized by rhegmatogenous retinal detachment, premature arthropathy, and development of phalangeal epiphyseal dysplasia, resulting in brachydactyly. Stature is normal, and high myopia, cleft palate, and midfacial hypoplasia are absent (Richards et al., 2002).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/343940">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_400145"><div><strong>Spondyloarthropathy, susceptibility to, 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>400145</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1862852</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div></div>
<div class="spaceAbove">Spondyloarthropathy (SpA), one of the commonest chronic rheumatic diseases, includes a spectrum of related disorders comprising the prototype ankylosing spondylitis (AS), a subset of psoriatic arthritis (PsA), reactive arthritis (ReA), arthritis associated with inflammatory bowel disease, and undifferentiated spondyloarthropathy (Miceli-Richard et al., 2004). These phenotypes are difficult to differentiate because they may occur simultaneously or sequentially in the same patient. Studies have suggested that a predominant shared component, including HLA-B27, predisposes to all phenotypic subsets, and that these subsets should be considered as various phenotypic expressions of the same disease (Said-Nahal et al., 2000, Said-Nahal et al., 2001).&#13; Braun and Sieper (2007) provided a detailed review of ankylosing spondylitis, including clinical features, pathogenesis, and management.&#13; Genetic Heterogeneity of Susceptibility to Spondyloarthropathy&#13; Additional susceptibility loci for spondyloarthropathy have been identified on chromosome 9q31-q34 (SPDA2; 183840) and chromosome 2q36 (SPDA3; 613238).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/400145">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_462437"><div><strong>Aneurysm-osteoarthritis syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462437</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3151087</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Loeys-Dietz syndrome (LDS) is characterized by vascular findings (cerebral, thoracic, and abdominal arterial aneurysms and/or dissections), skeletal manifestations (pectus excavatum or pectus carinatum, scoliosis, joint laxity, arachnodactyly, talipes equinovarus, and cervical spine malformation and/or instability), craniofacial features (hypertelorism, strabismus, bifid uvula / cleft palate, and craniosynostosis that can involve any sutures), and cutaneous findings (velvety and translucent skin, easy bruising, and dystrophic scars). Individuals with LDS are predisposed to widespread and aggressive arterial aneurysms and pregnancy-related complications including uterine rupture and death. Individuals with LDS can show a strong predisposition for allergic/inflammatory disease including asthma, eczema, and reactions to food or environmental allergens. There is also an increased incidence of gastrointestinal inflammation including eosinophilic esophagitis and gastritis or inflammatory bowel disease. Wide variation in the distribution and severity of clinical features can be seen in individuals with LDS, even among affected individuals within a family who have the same pathogenic variant.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/462437">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_465707"><div><strong>Autosomal dominant osteopetrosis 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>465707</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3179239</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">The spectrum of CLCN7-related osteopetrosis includes infantile malignant CLCN7-related autosomal recessive osteopetrosis (ARO), intermediate autosomal osteopetrosis (IAO), and autosomal dominant osteopetrosis type II (ADOII; Albers-Schönberg disease). ARO. Onset is at birth. Findings may include: fractures; reduced growth; sclerosis of the skull base (with or without choanal stenosis or hydrocephalus) resulting in optic nerve compression, facial palsy, and hearing loss; absence of the bone marrow cavity resulting in severe anemia and thrombocytopenia; dental abnormalities, odontomas, and risk for mandibular osteomyelitis; and hypocalcemia with tetanic seizures and secondary hyperparathyroidism. Without treatment maximal life span in ARO is ten years. IAO. Onset is in childhood. Findings may include: fractures after minor trauma, characteristic skeletal radiographic changes found incidentally, mild anemia, and occasional visual impairment secondary to optic nerve compression. Life expectancy in IAO is usually normal. ADOII. Onset is usually late childhood or adolescence. Findings may include: fractures (in any long bone and/or the posterior arch of a vertebra), scoliosis, hip osteoarthritis, and osteomyelitis of the mandible or septic osteitis or osteoarthritis elsewhere. Cranial nerve compression is rare.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/465707">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_762085"><div><strong>Spondyloepiphyseal dysplasia tarda, X-linked</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>762085</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3541456</a></dd><dt><span class="dotprefix"></span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
<div class="spaceAbove">X-linked spondyloepiphyseal dysplasia tarda is a condition that impairs bone growth and occurs almost exclusively in males. The name of the condition indicates that it affects the bones of the spine (spondylo-) and the ends of long bones (epiphyses) in the arms and legs. "Tarda" indicates that signs and symptoms of this condition are not present at birth, but appear later in childhood, typically between ages 6 and 10.\n\nMales with X-linked spondyloepiphyseal dysplasia tarda have skeletal abnormalities and short stature. Affected boys grow steadily until late childhood, when their growth slows. Their adult height ranges from 4 feet 6 inches (137 cm) to 5 feet 4 inches (163 cm). Impaired growth of the spinal bones (vertebrae) primarily causes the short stature. Spinal abnormalities include flattened vertebrae (platyspondyly) with hump-shaped bulges, progressive thinning of the discs between vertebrae, and an abnormal curvature of the spine (scoliosis or kyphosis). These spinal problems also cause back pain in people with this condition. Individuals with X-linked spondyloepiphyseal dysplasia tarda have a short torso and neck, and their arms are disproportionately long compared to their height.\n\nOther skeletal features of X-linked spondyloepiphyseal dysplasia tarda include an abnormality of the hip joint that causes the upper leg bones to turn inward (coxa vara); multiple abnormalities of the epiphyses, including a short upper end of the thigh bone (femoral neck); and a broad, barrel-shaped chest. A painful joint condition called osteoarthritis that typically occurs in older adults often develops in early adulthood in people with X-linked spondyloepiphyseal dysplasia tarda and worsens over time, most often affecting the hips, knees, and shoulders.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/762085">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_777109"><div><strong>Short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>777109</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3665488</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Patients with short sature and advanced bone age with or without early-onset osteoarthritis and/or osteochondritis dissecans (SSOAOD) exhibit a broad phenotypic spectrum involving short stature associated with advanced bone maturation and early-onset osteoarthritis, as well as mild dysmorphic features consisting of midface hypoplasia, brachydactyly, broad great toes, and lumbar lordosis. Other features include intervertebral disc disease and osteochondritis dissecans, which is characterized by separation of articular cartilage and subchondral bone from the articular surface. Phenotypes are highly variable even among patients within the same family, and there are no apparent genotype-phenotype correlations (summary by Dateki et al., 2017).&#13; The term 'dissecans' comes from 'dis' meaning 'from' and 'secare' meaning 'cut off,' and is not to be confused with 'desiccans' derived from 'desiccare' meaning to 'dry up.' Dissecans refers to the appearance of part of the bone having been cut away.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/777109">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_811575"><div><strong>Developmental dysplasia of the hip 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>811575</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3715079</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Developmental dysplasia of the hip (DDH) is a debilitating condition characterized by incomplete formation of the acetabulum leading to dislocation of the femur, suboptimal joint function, and accelerated wear of the articular cartilage, resulting in arthritis. Undetected hip dysplasia is the leading cause of osteoarthritis of the hip in young individuals, causing over 40% of cases in that age group (summary by Feldman et al., 2013).&#13; For discussion of genetic heterogeneity of developmental dysplasia of the hip, see DDH1 (142700).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/811575">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_854604"><div><strong>Osteoarthritis susceptibility 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>854604</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3887876</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div></div>
<div class="spaceAbove">Osteoarthritis is a common disease of the joints that primarily occurs in older adults. This condition is characterized by the breakdown of cartilage, the tough but flexible tissue that covers the ends of the bones at the joints and allows smooth joint movements. One or more parts of the body can be affected, most often the hands, shoulders, spine, knees, or hips.\n\nOsteoarthritis usually develops slowly, causing pain, stiffness, and restricted movement as the condition gets worse. Areas of bone no longer cushioned by cartilage rub against each other and start to break down. Further damage is caused as the body attempts to repair and rebuild these tissues. The immune system, which plays a role in healing injuries, targets these areas, and its response leads to inflammation of the joint tissues. Abnormal growths of bone (osteophytes) and other tissue can also occur, and may be visible as enlarged joints. Enlargement of the joints of the fingers is especially noticeable.\n\nPeople with osteoarthritis typically experience stiffness following periods of inactivity such as upon awakening or rising from a chair; the stiffness usually improves as they move around. In some affected individuals, the condition never causes major problems. In others, severe osteoarthritis can impair mobility and the ability to perform daily tasks, affecting quality of life and increasing the risk of other health conditions such as cardiovascular disease.\n\nOsteoarthritis is most common in middle age or late adulthood, because the cartilage at the joints naturally begins to thin as people age. However, it can occur earlier in life, especially after injuries affecting the joints such as a type of knee injury called an anterior cruciate ligament (ACL) tear. People who are overweight or whose activities are particularly stressful to the joints are also at increased risk of developing osteoarthritis.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/854604">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1648357"><div><strong>Peripheral dysostosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1648357</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4721502</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Peripheral dysostosis is a rare primary bone dysplasia characterized by cone-shaped epiphyses of the phalanges, hyperextensibility and hyperflexibility of the fingers and marked delay in ossification of hand bones. Short-limbed short stature, very stubby, short fingers and toes, flat face and nose and a large skull may also be associated. There have been no further descriptions in the literature since 1980.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1648357">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1794251"><div><strong>Loeys-Dietz syndrome 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1794251</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5562041</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Loeys-Dietz syndrome (LDS) is characterized by vascular findings (cerebral, thoracic, and abdominal arterial aneurysms and/or dissections), skeletal manifestations (pectus excavatum or pectus carinatum, scoliosis, joint laxity, arachnodactyly, talipes equinovarus, and cervical spine malformation and/or instability), craniofacial features (hypertelorism, strabismus, bifid uvula / cleft palate, and craniosynostosis that can involve any sutures), and cutaneous findings (velvety and translucent skin, easy bruising, and dystrophic scars). Individuals with LDS are predisposed to widespread and aggressive arterial aneurysms and pregnancy-related complications including uterine rupture and death. Individuals with LDS can show a strong predisposition for allergic/inflammatory disease including asthma, eczema, and reactions to food or environmental allergens. There is also an increased incidence of gastrointestinal inflammation including eosinophilic esophagitis and gastritis or inflammatory bowel disease. Wide variation in the distribution and severity of clinical features can be seen in individuals with LDS, even among affected individuals within a family who have the same pathogenic variant.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1794251">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462437" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Aneurysm-osteoarthritis syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_366028" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Angel-shaped phalango-epiphyseal dysplasia</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_465707" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal dominant osteopetrosis 2</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_811575" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Developmental dysplasia of the hip 2</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_57704" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Epiphysiolysis of the hip</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (15)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1794251" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Loeys-Dietz syndrome 6</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_325376" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Multiple epiphyseal dysplasia type 1</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_609409" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Namaqualand hip dysplasia</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_854604" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Osteoarthritis susceptibility 1</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1648357" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Peripheral dysostosis</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_777109" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_400145" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Spondyloarthropathy, susceptibility to, 1</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_338604" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Spondyloepiphyseal dysplasia tarda, autosomal recessive</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_762085" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Spondyloepiphyseal dysplasia tarda, X-linked</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_343940" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Vitreoretinopathy with phalangeal epiphyseal dysplasia</a></div></span></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/37394226">Recommendations for the management of hip and knee osteoarthritis: A systematic review of clinical practice guidelines.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gibbs AJ,
Gray B,
Wallis JA,
Taylor NF,
Kemp JL,
Hunter DJ,
Barton CJ</span><br />
<span class="medgenPMjournal">Osteoarthritis Cartilage</span>
2023 Oct;31(10):1280-1292.
Epub 2023 Jun 30
doi: 10.1016/j.joca.2023.05.015.
<span class="bold">PMID: </span><a href="/pubmed/37394226" target="_blank">37394226</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32643252">A clinical practice guideline for physical therapy in patients with hip or knee osteoarthritis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">van Doormaal MCM,
Meerhoff GA,
Vliet Vlieland TPM,
Peter WF</span><br />
<span class="medgenPMjournal">Musculoskeletal Care</span>
2020 Dec;18(4):575-595.
Epub 2020 Jul 9
doi: 10.1002/msc.1492.
<span class="bold">PMID: </span><a href="/pubmed/32643252" target="_blank">32643252</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23896330">Physiotherapy management of hip osteoarthritis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bennell K</span><br />
<span class="medgenPMjournal">J Physiother</span>
2013 Sep;59(3):145-57.
doi: 10.1016/S1836-9553(13)70179-6.
<span class="bold">PMID: </span><a href="/pubmed/23896330" target="_blank">23896330</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22osteoarthritis%2C%20hip%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (164)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nice.org.uk/guidance/ng226" target="_blank">UK NICE Guideline NG226, Osteoarthritis in over 16s: diagnosis and management, 2022</a></h3>
</div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/29309269">Hip Osteoarthritis: A Primer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lespasio MJ,
Sultan AA,
Piuzzi NS,
Khlopas A,
Husni ME,
Muschler GF,
Mont MA</span><br />
<span class="medgenPMjournal">Perm J</span>
2018;22:17-084.
doi: 10.7812/TPP/17-084.
<span class="bold">PMID: </span><a href="/pubmed/29309269" target="_blank">29309269</a><a href="/pmc/articles/PMC5760056" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27671326">Hip Osteoarthritis: Etiopathogenesis and Implications for Management.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Murphy NJ,
Eyles JP,
Hunter DJ</span><br />
<span class="medgenPMjournal">Adv Ther</span>
2016 Nov;33(11):1921-1946.
Epub 2016 Sep 26
doi: 10.1007/s12325-016-0409-3.
<span class="bold">PMID: </span><a href="/pubmed/27671326" target="_blank">27671326</a><a href="/pmc/articles/PMC5083776" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26738905">Hip Dysplasia in the Young Adult.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gala L,
Clohisy JC,
Beaulé PE</span><br />
<span class="medgenPMjournal">J Bone Joint Surg Am</span>
2016 Jan 6;98(1):63-73.
doi: 10.2106/JBJS.O.00109.
<span class="bold">PMID: </span><a href="/pubmed/26738905" target="_blank">26738905</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23896330">Physiotherapy management of hip osteoarthritis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bennell K</span><br />
<span class="medgenPMjournal">J Physiother</span>
2013 Sep;59(3):145-57.
doi: 10.1016/S1836-9553(13)70179-6.
<span class="bold">PMID: </span><a href="/pubmed/23896330" target="_blank">23896330</a></div>
<div class="nl"><a target="_blank" href="/pubmed/18687270">Epidemiology of osteoarthritis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang Y,
Jordan JM</span><br />
<span class="medgenPMjournal">Rheum Dis Clin North Am</span>
2008 Aug;34(3):515-29.
doi: 10.1016/j.rdc.2008.05.007.
<span class="bold">PMID: </span><a href="/pubmed/18687270" target="_blank">18687270</a><a href="/pmc/articles/PMC4384650" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Osteoarthritis%2C%20hip%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5772)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/34600121">How does hip osteoarthritis differ from knee osteoarthritis?</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hall M,
van der Esch M,
Hinman RS,
Peat G,
de Zwart A,
Quicke JG,
Runhaar J,
Knoop J,
van der Leeden M,
de Rooij M,
Meulenbelt I,
Vliet Vlieland T,
Lems WF,
Holden MA,
Foster NE,
Bennell KL</span><br />
<span class="medgenPMjournal">Osteoarthritis Cartilage</span>
2022 Jan;30(1):32-41.
Epub 2021 Sep 29
doi: 10.1016/j.joca.2021.09.010.
<span class="bold">PMID: </span><a href="/pubmed/34600121" target="_blank">34600121</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31034380">Osteoarthritis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hunter DJ,
Bierma-Zeinstra S</span><br />
<span class="medgenPMjournal">Lancet</span>
2019 Apr 27;393(10182):1745-1759.
doi: 10.1016/S0140-6736(19)30417-9.
<span class="bold">PMID: </span><a href="/pubmed/31034380" target="_blank">31034380</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28566053">Hip Pain and Mobility Deficits-Hip Osteoarthritis: Revision 2017.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cibulka MT,
Bloom NJ,
Enseki KR,
Macdonald CW,
Woehrle J,
McDonough CM</span><br />
<span class="medgenPMjournal">J Orthop Sports Phys Ther</span>
2017 Jun;47(6):A1-A37.
doi: 10.2519/jospt.2017.0301.
<span class="bold">PMID: </span><a href="/pubmed/28566053" target="_blank">28566053</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27671326">Hip Osteoarthritis: Etiopathogenesis and Implications for Management.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Murphy NJ,
Eyles JP,
Hunter DJ</span><br />
<span class="medgenPMjournal">Adv Ther</span>
2016 Nov;33(11):1921-1946.
Epub 2016 Sep 26
doi: 10.1007/s12325-016-0409-3.
<span class="bold">PMID: </span><a href="/pubmed/27671326" target="_blank">27671326</a><a href="/pmc/articles/PMC5083776" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27383835">Hip osteoarthritis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Aresti N,
Kassam J,
Nicholas N,
Achan P</span><br />
<span class="medgenPMjournal">BMJ</span>
2016 Jul 6;354:i3405.
doi: 10.1136/bmj.i3405.
<span class="bold">PMID: </span><a href="/pubmed/27383835" target="_blank">27383835</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Osteoarthritis%2C%20hip%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2219)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/31121333">Efficacy and potential determinants of exercise therapy in knee and hip osteoarthritis: A systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Goh SL,
Persson MSM,
Stocks J,
Hou Y,
Lin J,
Hall MC,
Doherty M,
Zhang W</span><br />
<span class="medgenPMjournal">Ann Phys Rehabil Med</span>
2019 Sep;62(5):356-365.
Epub 2019 May 21
doi: 10.1016/j.rehab.2019.04.006.
<span class="bold">PMID: </span><a href="/pubmed/31121333" target="_blank">31121333</a><a href="/pmc/articles/PMC6880792" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31034380">Osteoarthritis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hunter DJ,
Bierma-Zeinstra S</span><br />
<span class="medgenPMjournal">Lancet</span>
2019 Apr 27;393(10182):1745-1759.
doi: 10.1016/S0140-6736(19)30417-9.
<span class="bold">PMID: </span><a href="/pubmed/31034380" target="_blank">31034380</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28386761">Platelet-Rich Plasma for the Management of Hip and Knee Osteoarthritis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bennell KL,
Hunter DJ,
Paterson KL</span><br />
<span class="medgenPMjournal">Curr Rheumatol Rep</span>
2017 May;19(5):24.
doi: 10.1007/s11926-017-0652-x.
<span class="bold">PMID: </span><a href="/pubmed/28386761" target="_blank">28386761</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27007113">Aquatic exercise for the treatment of knee and hip osteoarthritis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bartels EM,
Juhl CB,
Christensen R,
Hagen KB,
Danneskiold-Samsøe B,
Dagfinrud H,
Lund H</span><br />
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
2016 Mar 23;3(3):CD005523.
doi: 10.1002/14651858.CD005523.pub3.
<span class="bold">PMID: </span><a href="/pubmed/27007113" target="_blank">27007113</a><a href="/pmc/articles/PMC9942938" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19238130">Rehabilitation after total hip arthroplasty: a systematic review of controlled trials on physical exercise programs.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Di Monaco M,
Vallero F,
Tappero R,
Cavanna A</span><br />
<span class="medgenPMjournal">Eur J Phys Rehabil Med</span>
2009 Sep;45(3):303-17.
Epub 2009 Feb 23
<span class="bold">PMID: </span><a href="/pubmed/19238130" target="_blank">19238130</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Osteoarthritis%2C%20hip%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3178)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/35598766">Burden of osteoarthritis in India and its states, 1990-2019: findings from the Global Burden of disease study 2019.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Singh A,
Das S,
Chopra A,
Danda D,
Paul BJ,
March L,
Mathew AJ,
Shenoy P,
Gotay C,
Palmer AJ,
Antony B</span><br />
<span class="medgenPMjournal">Osteoarthritis Cartilage</span>
2022 Aug;30(8):1070-1078.
Epub 2022 May 19
doi: 10.1016/j.joca.2022.05.004.
<span class="bold">PMID: </span><a href="/pubmed/35598766" target="_blank">35598766</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26900724">Psychiatric disease as a risk factor in fast-track hip and knee replacement.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gylvin SH,
Jørgensen CC,
Fink-Jensen A,
Kehlet H</span><br />
<span class="medgenPMjournal">Acta Orthop</span>
2016 Oct;87(5):439-43.
Epub 2016 Feb 22
doi: 10.3109/17453674.2016.1151292.
<span class="bold">PMID: </span><a href="/pubmed/26900724" target="_blank">26900724</a><a href="/pmc/articles/PMC5016900" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26378270">What's New in Hip Replacement.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ninomiya JT,
Dean JC,
Incavo SJ</span><br />
<span class="medgenPMjournal">J Bone Joint Surg Am</span>
2015 Sep 16;97(18):1543-51.
doi: 10.2106/JBJS.O.00526.
<span class="bold">PMID: </span><a href="/pubmed/26378270" target="_blank">26378270</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21665124">Osteoarthritis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Busija L,
Bridgett L,
Williams SR,
Osborne RH,
Buchbinder R,
March L,
Fransen M</span><br />
<span class="medgenPMjournal">Best Pract Res Clin Rheumatol</span>
2010 Dec;24(6):757-68.
doi: 10.1016/j.berh.2010.11.001.
<span class="bold">PMID: </span><a href="/pubmed/21665124" target="_blank">21665124</a></div>
<div class="nl"><a target="_blank" href="/pubmed/15132348">Do risk factors for incident hip osteoarthritis (OA) differ from those for progression of hip OA?</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hochberg MC</span><br />
<span class="medgenPMjournal">J Rheumatol Suppl</span>
2004 Apr;70:6-9.
<span class="bold">PMID: </span><a href="/pubmed/15132348" target="_blank">15132348</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Osteoarthritis%2C%20hip%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2829)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/27998033">Current Physical Activity Monitors in Hip and Knee Osteoarthritis: A Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sliepen M,
Brandes M,
Rosenbaum D</span><br />
<span class="medgenPMjournal">Arthritis Care Res (Hoboken)</span>
2017 Oct;69(10):1460-1466.
Epub 2017 Sep 6
doi: 10.1002/acr.23170.
<span class="bold">PMID: </span><a href="/pubmed/27998033" target="_blank">27998033</a><a href="/pmc/articles/PMC5656924" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23312418">Targeting care: tailoring nonsurgical management according to clinical presentation.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Eyles J,
Lucas BR,
Hunter DJ</span><br />
<span class="medgenPMjournal">Rheum Dis Clin North Am</span>
2013 Feb;39(1):213-33.
Epub 2012 Nov 26
doi: 10.1016/j.rdc.2012.11.001.
<span class="bold">PMID: </span><a href="/pubmed/23312418" target="_blank">23312418</a></div>
<div class="nl"><a target="_blank" href="/pubmed/15207508">Minimal clinically important changes in chronic musculoskeletal pain intensity measured on a numerical rating scale.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Salaffi F,
Stancati A,
Silvestri CA,
Ciapetti A,
Grassi W</span><br />
<span class="medgenPMjournal">Eur J Pain</span>
2004 Aug;8(4):283-91.
doi: 10.1016/j.ejpain.2003.09.004.
<span class="bold">PMID: </span><a href="/pubmed/15207508" target="_blank">15207508</a></div>
<div class="nl"><a target="_blank" href="/pubmed/10419791">Radiographic assessment of hip and knee osteoarthritis. Recommendations: recommended guidelines.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Vignon E,
Conrozier T,
Piperno M,
Richard S,
Carrillon Y,
Fantino O</span><br />
<span class="medgenPMjournal">Osteoarthritis Cartilage</span>
1999 Jul;7(4):434-6.
doi: 10.1053/joca.1999.0235.
<span class="bold">PMID: </span><a href="/pubmed/10419791" target="_blank">10419791</a></div>
<div class="nl"><a target="_blank" href="/pubmed/1888195">Osteoarthritis of the hip and osteoporosis of the proximal femur.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cooper C,
Cook PL,
Osmond C,
Fisher L,
Cawley MI</span><br />
<span class="medgenPMjournal">Ann Rheum Dis</span>
1991 Aug;50(8):540-2.
doi: 10.1136/ard.50.8.540.
<span class="bold">PMID: </span><a href="/pubmed/1888195" target="_blank">1888195</a><a href="/pmc/articles/PMC1004483" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Osteoarthritis%2C%20hip%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4085)</a></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="nl"><a target="_blank" href="/pubmed/37394226">Recommendations for the management of hip and knee osteoarthritis: A systematic review of clinical practice guidelines.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gibbs AJ,
Gray B,
Wallis JA,
Taylor NF,
Kemp JL,
Hunter DJ,
Barton CJ</span><br />
<span class="medgenPMjournal">Osteoarthritis Cartilage</span>
2023 Oct;31(10):1280-1292.
Epub 2023 Jun 30
doi: 10.1016/j.joca.2023.05.015.
<span class="bold">PMID: </span><a href="/pubmed/37394226" target="_blank">37394226</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33635329">Evaluation of Exercise Interventions and Outcomes After Hip Arthroplasty: A Systematic Review and Meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Saueressig T,
Owen PJ,
Zebisch J,
Herbst M,
Belavy DL</span><br />
<span class="medgenPMjournal">JAMA Netw Open</span>
2021 Feb 1;4(2):e210254.
doi: 10.1001/jamanetworkopen.2021.0254.
<span class="bold">PMID: </span><a href="/pubmed/33635329" target="_blank">33635329</a><a href="/pmc/articles/PMC7910817" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33474984">Best Practices: Hip Femoroacetabular Impingement.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Schmaranzer F,
Kheterpal AB,
Bredella MA</span><br />
<span class="medgenPMjournal">AJR Am J Roentgenol</span>
2021 Mar;216(3):585-598.
Epub 2021 Jan 21
doi: 10.2214/AJR.20.22783.
<span class="bold">PMID: </span><a href="/pubmed/33474984" target="_blank">33474984</a><a href="/pmc/articles/PMC8116615" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32643252">A clinical practice guideline for physical therapy in patients with hip or knee osteoarthritis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">van Doormaal MCM,
Meerhoff GA,
Vliet Vlieland TPM,
Peter WF</span><br />
<span class="medgenPMjournal">Musculoskeletal Care</span>
2020 Dec;18(4):575-595.
Epub 2020 Jul 9
doi: 10.1002/msc.1492.
<span class="bold">PMID: </span><a href="/pubmed/32643252" target="_blank">32643252</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27007113">Aquatic exercise for the treatment of knee and hip osteoarthritis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bartels EM,
Juhl CB,
Christensen R,
Hagen KB,
Danneskiold-Samsøe B,
Dagfinrud H,
Lund H</span><br />
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
2016 Mar 23;3(3):CD005523.
doi: 10.1002/14651858.CD005523.pub3.
<span class="bold">PMID: </span><a href="/pubmed/27007113" target="_blank">27007113</a><a href="/pmc/articles/PMC9942938" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Osteoarthritis%2C%20hip%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (379)</a></div></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0029410%5bDISCUI%5d&amp;filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (6)</a></li>
<li><a href="/gtr/tests?term=C0029410%5bDISCUI%5d&amp;filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (7)</a></li>
<li><a href="/gtr/tests?term=C0029410%5bDISCUI%5d&amp;filter=method%3A2%5F19" target="_blank">Targeted variant analysis (2)</a></li>
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0029410%5bDISCUI%5d" target="_blank">See all (7)</a></total></li>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Osteoarthritis,%20hip" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22osteoarthritis%2C%20hip%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Osteoarthritis%2C%20hip%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nice.org.uk/guidance/ng226">NICE, 2022</a><div>UK NICE Guideline NG226, Osteoarthritis in over 16s: diagnosis and management, 2022</div></li></ul></div>
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