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<meta name="keywords" content="C0428791, aortic stenosis, calcific, aortic valve calcification, aortic valve calcification (disease), aortic valve calcifications, aortic valve, calcification of, calcification of aortic valve, calcified aortic valve, disease or syndrome, finding, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Deposition of calcium salts in the aortic valve." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Aortic valve calcification (Concept Id: C0428791)
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<!--
UID=140899
ConceptID=C0428791
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Aortic valve calcification</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>140899</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0428791</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome; Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Aortic Stenosis, Calcific; Aortic Valve, Calcification of</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Aortic valve calcification (250978003); Calcified aortic valve (250978003)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0004380">HP:0004380</a></td></tr>
<tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0005463" target="_blank">MONDO:0005463</a></td></tr>
<tr><td>OMIM<span class="superscript">®</span>:</td>
<td><a href="https://omim.org/entry/109730" target="_blank">109730</a></td></tr>
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">Deposition of calcium salts in the aortic valve. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1260873[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=226776">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=226776" target="_blank" href="/omim/109730">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=226776" ref="ncbi_uid=226776">V</a></span></span><span class="TLline"><a href="/medgen/226776" ref="tree=GTR&amp;ncbi_uid=226776&amp;link_uid=226776" title="View MedGen record for 'Aortic valve disorder'">Aortic valve disorder</a></span><ul><li class="TLclosed"><span class="TLline"><a href="/medgen/451016" ref="tree=GTR&amp;ncbi_uid=451016&amp;link_uid=451016" title="View MedGen record for 'Aortic valve atresia'">Aortic valve atresia</a></span></li><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=140899" target="_blank" href="/omim/109730">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Aortic valve calcification</span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3887892[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=854610">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=854610" target="_blank" href="/omim/109730">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=854610" ref="ncbi_uid=854610">V</a></span></span><span class="TLline"><a href="/medgen/854610" ref="tree=GTR&amp;ncbi_uid=854610&amp;link_uid=854610" title="View MedGen record for 'Aortic valve disease 1'">Aortic valve disease 1</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3542024[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=762200">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=762200" target="_blank" href="/omim/602931">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=762200" ref="ncbi_uid=762200">V</a></span></span><span class="TLline"><a href="/medgen/762200" ref="tree=GTR&amp;ncbi_uid=762200&amp;link_uid=762200" title="View MedGen record for 'Aortic valve disease 2'">Aortic valve disease 2</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C5193127[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=1681142">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=1681142" target="_blank" href="/omim/607528">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=1681142" ref="ncbi_uid=1681142">V</a></span></span><span class="TLline"><a href="/medgen/1681142" ref="tree=GTR&amp;ncbi_uid=1681142&amp;link_uid=1681142" title="View MedGen record for 'Aortic valve disease 3'">Aortic valve disease 3</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/1619" ref="tree=GTR&amp;ncbi_uid=1619&amp;link_uid=1619" title="View MedGen record for 'Aortic valve prolapse'">Aortic valve prolapse</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=1621" target="_blank" href="/omim/614823">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=1621" ref="ncbi_uid=1621">V</a></span></span><span class="TLline"><a href="/medgen/1621" ref="tree=GTR&amp;ncbi_uid=1621&amp;link_uid=1621" title="View MedGen record for 'Aortic valve stenosis'">Aortic valve stenosis</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/1670287" ref="tree=GTR&amp;ncbi_uid=1670287&amp;link_uid=1670287" title="View MedGen record for 'Familial bicuspid aortic valve'">Familial bicuspid aortic valve</a></span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/2848" ref="tree=MeSH" title="MedGen record for Disorder of cardiovascular system">Disorder of cardiovascular system</a></span><ul><li><span class="TLline"><a href="/medgen/5458" ref="tree=MeSH" title="MedGen record for Heart disease">Heart disease</a></span><ul><li><span class="TLline"><a href="/medgen/5463" ref="tree=MeSH" title="MedGen record for cardiac valvular disease">cardiac valvular disease</a></span><ul><li><span class="TLline"><a href="/medgen/226776" ref="tree=MeSH" title="MedGen record for Aortic valve disorder">Aortic valve disorder</a></span><ul><li><span class="matched_ds">Aortic valve calcification</span><ul><li><span class="TLline"><a href="/medgen/1788204" ref="tree=MeSH" title="MedGen record for Aortic annulus calcification">Aortic annulus calcification</a></span></li><li><span class="TLline"><a href="/medgen/1788751" ref="tree=MeSH" title="MedGen record for Aortic valve leaflet calcification">Aortic valve leaflet calcification</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_1413"><div><strong>Alkaptonuria</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1413</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C0002066</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Alkaptonuria is caused by deficiency of homogentisate 1,2-dioxygenase, an enzyme that converts homogentisic acid (HGA) to maleylacetoacetic acid in the tyrosine degradation pathway. The three major features of alkaptonuria are dark urine or urine that turns dark on standing, ochronosis (bluish-black pigmentation in connective tissue), and arthritis of the spine and larger joints. Ochronosis generally occurs after age 30 years; arthritis often begins in the third decade. Other manifestations can include pigment in the sclera, ear cartilage, and skin of the hands; aortic or mitral valve calcification or regurgitation and occasionally aortic dilatation; renal stones; prostate stones; and hypothyroidism.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1413">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_341563"><div><strong>Gaucher disease-ophthalmoplegia-cardiovascular calcification syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>341563</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1856476</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Gaucher disease (GD) encompasses a continuum of clinical findings from a perinatal-lethal disorder to an asymptomatic type. The characterization of three major clinical types (1, 2, and 3) and two clinical forms (perinatal-lethal and cardiovascular) is useful in determining prognosis and management. Cardiopulmonary complications have been described with all the clinical phenotypes, although varying in frequency and severity. Type 1 GD is characterized by the presence of clinical or radiographic evidence of bone disease (osteopenia, focal lytic or sclerotic lesions, and osteonecrosis), hepatosplenomegaly, anemia, thrombocytopenia, lung disease, and the absence of primary central nervous system disease. Type 2 GD is characterized by primary central nervous system disease with onset before age two years, limited psychomotor development, and a rapidly progressive course with death by age two to four years. Type 3 GD is characterized by primary central nervous system disease with childhood onset, a more slowly progressive course, and survival into the third or fourth decade. The perinatal-lethal form is associated with ichthyosiform or collodion skin abnormalities or with nonimmune hydrops fetalis. The cardiovascular form is characterized by calcification of the aortic and mitral valves, mild splenomegaly, corneal opacities, and supranuclear ophthalmoplegia.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/341563">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_354631"><div><strong>Calcific aortic disease with immunologic abnormalities, familial</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>354631</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1861974</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove nowrap">See: <a href="/medgen/354631">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_854610"><div><strong>Aortic valve disease 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>854610</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3887892</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">An autosomal dominant form of bicuspid aortic valve caused by mutation(s) in the NOTCH1 gene, encoding neurogenic locus notch homolog protein 1.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/854610">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_907372"><div><strong>Singleton-Merten syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>907372</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4225380</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Singleton-Merten syndrome-2 is characterized by variable expression of glaucoma, aortic calcification, and skeletal abnormalities, without dental anomalies (summary by Jang et al., 2015).&#13; For a general phenotypic description and discussion of genetic heterogeneity of Singleton-Merten syndrome, see SGMRT1 (182250).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/907372">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_899946"><div><strong>Singleton-Merten syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>899946</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4225427</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Singleton-Merten syndrome (SGMRT) is an uncommon autosomal dominant disorder characterized by abnormalities of blood vessels, teeth, and bone. Calcifications of the aorta and aortic and mitral valves occur in childhood or puberty and can lead to early death. Dental findings include delayed primary tooth exfoliation and permanent tooth eruption, truncated tooth root formation, early-onset periodontal disease, and severe root and alveolar bone resorption associated with dysregulated mineralization, leading to tooth loss. Osseous features consist of osteoporosis, either generalized or limited to distal extremities, distal limb osteolysis, widened medullary cavities, and easy tearing of tendons from bone. Less common features are mild facial dysmorphism (high anterior hair line, broad forehead, smooth philtrum, thin upper vermilion border), generalized muscle weakness, psoriasis, early-onset glaucoma, and recurrent infections. The disorder manifests with variable inter- and intrafamilial phenotypes (summary by Rutsch et al., 2015).&#13; Genetic Heterogeneity of Singleton-Merten Syndrome&#13; An atypical form of Singleton-Merten syndrome (SGMRT2; 616298) is caused by mutation in the DDX58 gene (609631) on chromosome 9p21.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/899946">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1413" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Alkaptonuria</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_854610" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Aortic valve disease 1</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_354631" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Calcific aortic disease with immunologic abnormalities, familial</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_341563" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Gaucher disease-ophthalmoplegia-cardiovascular calcification syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_899946" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Singleton-Merten syndrome 1</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_907372" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Singleton-Merten syndrome 2</a></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/32920070">Upregulation of microRNA-195 might be a novel therapeutic target in the treatment of aortic valve calcification.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sun W,
Qu L</span><br />
<span class="medgenPMjournal">Int J Cardiol</span>
2021 Jan 1;322:206.
Epub 2020 Sep 10
doi: 10.1016/j.ijcard.2020.09.022.
<span class="bold">PMID: </span><a href="/pubmed/32920070" target="_blank">32920070</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30661546">IL-18 might be a novel therapeutic target in the treatment of aortic valve calcification.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wang B,
Lin H,
Mao Z</span><br />
<span class="medgenPMjournal">Int J Cardiol</span>
2019 Feb 15;277:223.
doi: 10.1016/j.ijcard.2018.08.094.
<span class="bold">PMID: </span><a href="/pubmed/30661546" target="_blank">30661546</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28005568">Dilemma in the therapeutic management of low-gradient aortic stenosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Clavel MA,
Côté N,
Pibarot P</span><br />
<span class="medgenPMjournal">Curr Opin Cardiol</span>
2017 Mar;32(2):147-151.
doi: 10.1097/HCO.0000000000000374.
<span class="bold">PMID: </span><a href="/pubmed/28005568" target="_blank">28005568</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22aortic%20valve%20calcification%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (21)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/37887316">Lipoprotein(a)-60 Years Later-What Do We Know?</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pasławska A,
Tomasik PJ</span><br />
<span class="medgenPMjournal">Cells</span>
2023 Oct 17;12(20)
doi: 10.3390/cells12202472.
<span class="bold">PMID: </span><a href="/pubmed/37887316" target="_blank">37887316</a><a href="/pmc/articles/PMC10605347" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36829083">Calcific aortic valve disease: mechanisms, prevention and treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Moncla LM,
Briend M,
Bossé Y,
Mathieu P</span><br />
<span class="medgenPMjournal">Nat Rev Cardiol</span>
2023 Aug;20(8):546-559.
Epub 2023 Feb 24
doi: 10.1038/s41569-023-00845-7.
<span class="bold">PMID: </span><a href="/pubmed/36829083" target="_blank">36829083</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35465686">Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Diederichsen ACP,
Lindholt JS,
Möller S,
Øvrehus KA,
Auscher S,
Lambrechtsen J,
Hosbond SE,
Alan DH,
Urbonaviciene G,
Becker SW,
Fredgart MH,
Hasific S,
Folkestad L,
Gerke O,
Rasmussen LM,
Møller JE,
Mickley H,
Dahl JS</span><br />
<span class="medgenPMjournal">Circulation</span>
2022 May 3;145(18):1387-1397.
Epub 2022 Apr 25
doi: 10.1161/CIRCULATIONAHA.121.057008.
<span class="bold">PMID: </span><a href="/pubmed/35465686" target="_blank">35465686</a><a href="/pmc/articles/PMC9047644" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30732864">New Frontiers in Lp(a)-Targeted Therapies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Borrelli MJ,
Youssef A,
Boffa MB,
Koschinsky ML</span><br />
<span class="medgenPMjournal">Trends Pharmacol Sci</span>
2019 Mar;40(3):212-225.
Epub 2019 Feb 4
doi: 10.1016/j.tips.2019.01.004.
<span class="bold">PMID: </span><a href="/pubmed/30732864" target="_blank">30732864</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27767996">Aortic Valve Calcification and the Risk of dementia: A Population-Based Study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wolters FJ,
Bos D,
Vernooij MW,
Franco OH;
Heart-Brain Connection collaborative research group,
Hofman A,
Koudstaal PJ,
van der Lugt A,
Ikram MA</span><br />
<span class="medgenPMjournal">J Alzheimers Dis</span>
2017;55(3):893-897.
doi: 10.3233/JAD-160871.
<span class="bold">PMID: </span><a href="/pubmed/27767996" target="_blank">27767996</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Aortic%20valve%20calcification%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (834)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/37887316">Lipoprotein(a)-60 Years Later-What Do We Know?</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pasławska A,
Tomasik PJ</span><br />
<span class="medgenPMjournal">Cells</span>
2023 Oct 17;12(20)
doi: 10.3390/cells12202472.
<span class="bold">PMID: </span><a href="/pubmed/37887316" target="_blank">37887316</a><a href="/pmc/articles/PMC10605347" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37264340">Screening of immune-related secretory proteins linking chronic kidney disease with calcific aortic valve disease based on comprehensive bioinformatics analysis and machine learning.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zhu E,
Shu X,
Xu Z,
Peng Y,
Xiang Y,
Liu Y,
Guan H,
Zhong M,
Li J,
Zhang LZ,
Nie R,
Zheng Z</span><br />
<span class="medgenPMjournal">J Transl Med</span>
2023 Jun 1;21(1):359.
doi: 10.1186/s12967-023-04171-x.
<span class="bold">PMID: </span><a href="/pubmed/37264340" target="_blank">37264340</a><a href="/pmc/articles/PMC10234004" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31753206">Aortic Stenosis and Cardiac Amyloidosis: JACC Review Topic of the Week.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ternacle J,
Krapf L,
Mohty D,
Magne J,
Nguyen A,
Galat A,
Gallet R,
Teiger E,
Côté N,
Clavel MA,
Tournoux F,
Pibarot P,
Damy T</span><br />
<span class="medgenPMjournal">J Am Coll Cardiol</span>
2019 Nov 26;74(21):2638-2651.
doi: 10.1016/j.jacc.2019.09.056.
<span class="bold">PMID: </span><a href="/pubmed/31753206" target="_blank">31753206</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31488252">Why and How to Measure Aortic Valve Calcification in Patients With Aortic Stenosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pawade T,
Sheth T,
Guzzetti E,
Dweck MR,
Clavel MA</span><br />
<span class="medgenPMjournal">JACC Cardiovasc Imaging</span>
2019 Sep;12(9):1835-1848.
doi: 10.1016/j.jcmg.2019.01.045.
<span class="bold">PMID: </span><a href="/pubmed/31488252" target="_blank">31488252</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27188578">Calcific aortic stenosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lindman BR,
Clavel MA,
Mathieu P,
Iung B,
Lancellotti P,
Otto CM,
Pibarot P</span><br />
<span class="medgenPMjournal">Nat Rev Dis Primers</span>
2016 Mar 3;2:16006.
doi: 10.1038/nrdp.2016.6.
<span class="bold">PMID: </span><a href="/pubmed/27188578" target="_blank">27188578</a><a href="/pmc/articles/PMC5127286" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Aortic%20valve%20calcification%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (533)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/38502885">Morusin Alleviates Aortic Valve Calcification by Inhibiting Valve Interstitial Cell Senescence Through Ccnd1/Trim25/Nrf2 Axis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Liu Z,
Wang K,
Jiang C,
Chen Y,
Liu F,
Xie M,
Yim WY,
Yao D,
Qian X,
Chen S,
Shi J,
Xu K,
Wang Y,
Dong N</span><br />
<span class="medgenPMjournal">Adv Sci (Weinh)</span>
2024 May;11(20):e2307319.
Epub 2024 Mar 19
doi: 10.1002/advs.202307319.
<span class="bold">PMID: </span><a href="/pubmed/38502885" target="_blank">38502885</a><a href="/pmc/articles/PMC11132047" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37972628">Treatment of severe symptomatic aortic valve stenosis using non-invasive ultrasound therapy: a cohort study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Messas E,
Ijsselmuiden A,
Trifunović-Zamaklar D,
Cholley B,
Puymirat E,
Halim J,
Karan R,
van Gameren M,
Terzić D,
Milićević V,
Tanter M,
Pernot M,
Goudot G</span><br />
<span class="medgenPMjournal">Lancet</span>
2023 Dec 16;402(10419):2317-2325.
Epub 2023 Nov 14
doi: 10.1016/S0140-6736(23)01518-0.
<span class="bold">PMID: </span><a href="/pubmed/37972628" target="_blank">37972628</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37264340">Screening of immune-related secretory proteins linking chronic kidney disease with calcific aortic valve disease based on comprehensive bioinformatics analysis and machine learning.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zhu E,
Shu X,
Xu Z,
Peng Y,
Xiang Y,
Liu Y,
Guan H,
Zhong M,
Li J,
Zhang LZ,
Nie R,
Zheng Z</span><br />
<span class="medgenPMjournal">J Transl Med</span>
2023 Jun 1;21(1):359.
doi: 10.1186/s12967-023-04171-x.
<span class="bold">PMID: </span><a href="/pubmed/37264340" target="_blank">37264340</a><a href="/pmc/articles/PMC10234004" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35465686">Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Diederichsen ACP,
Lindholt JS,
Möller S,
Øvrehus KA,
Auscher S,
Lambrechtsen J,
Hosbond SE,
Alan DH,
Urbonaviciene G,
Becker SW,
Fredgart MH,
Hasific S,
Folkestad L,
Gerke O,
Rasmussen LM,
Møller JE,
Mickley H,
Dahl JS</span><br />
<span class="medgenPMjournal">Circulation</span>
2022 May 3;145(18):1387-1397.
Epub 2022 Apr 25
doi: 10.1161/CIRCULATIONAHA.121.057008.
<span class="bold">PMID: </span><a href="/pubmed/35465686" target="_blank">35465686</a><a href="/pmc/articles/PMC9047644" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27188578">Calcific aortic stenosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lindman BR,
Clavel MA,
Mathieu P,
Iung B,
Lancellotti P,
Otto CM,
Pibarot P</span><br />
<span class="medgenPMjournal">Nat Rev Dis Primers</span>
2016 Mar 3;2:16006.
doi: 10.1038/nrdp.2016.6.
<span class="bold">PMID: </span><a href="/pubmed/27188578" target="_blank">27188578</a><a href="/pmc/articles/PMC5127286" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Aortic%20valve%20calcification%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (398)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/37264340">Screening of immune-related secretory proteins linking chronic kidney disease with calcific aortic valve disease based on comprehensive bioinformatics analysis and machine learning.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zhu E,
Shu X,
Xu Z,
Peng Y,
Xiang Y,
Liu Y,
Guan H,
Zhong M,
Li J,
Zhang LZ,
Nie R,
Zheng Z</span><br />
<span class="medgenPMjournal">J Transl Med</span>
2023 Jun 1;21(1):359.
doi: 10.1186/s12967-023-04171-x.
<span class="bold">PMID: </span><a href="/pubmed/37264340" target="_blank">37264340</a><a href="/pmc/articles/PMC10234004" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31488252">Why and How to Measure Aortic Valve Calcification in Patients With Aortic Stenosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pawade T,
Sheth T,
Guzzetti E,
Dweck MR,
Clavel MA</span><br />
<span class="medgenPMjournal">JACC Cardiovasc Imaging</span>
2019 Sep;12(9):1835-1848.
doi: 10.1016/j.jcmg.2019.01.045.
<span class="bold">PMID: </span><a href="/pubmed/31488252" target="_blank">31488252</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26541169">The modern epidemiology of heart valve disease.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Coffey S,
Cairns BJ,
Iung B</span><br />
<span class="medgenPMjournal">Heart</span>
2016 Jan;102(1):75-85.
Epub 2015 Nov 5
doi: 10.1136/heartjnl-2014-307020.
<span class="bold">PMID: </span><a href="/pubmed/26541169" target="_blank">26541169</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26198161">Risk Stratification in Patients With Aortic Stenosis Using Novel Imaging Approaches.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chin CW,
Pawade TA,
Newby DE,
Dweck MR</span><br />
<span class="medgenPMjournal">Circ Cardiovasc Imaging</span>
2015 Aug;8(8):e003421.
doi: 10.1161/CIRCIMAGING.115.003421.
<span class="bold">PMID: </span><a href="/pubmed/26198161" target="_blank">26198161</a><a href="/pmc/articles/PMC4539578" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23861452">Computed tomographic imaging of transcatheter aortic valve replacement for prediction and prevention of procedural complications.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Leipsic J,
Yang TH,
Min JK</span><br />
<span class="medgenPMjournal">Circ Cardiovasc Imaging</span>
2013 Jul;6(4):597-605.
doi: 10.1161/CIRCIMAGING.113.000334.
<span class="bold">PMID: </span><a href="/pubmed/23861452" target="_blank">23861452</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Aortic%20valve%20calcification%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (521)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/35865542">Identification of Immune-Associated Genes in Diagnosing Aortic Valve Calcification With Metabolic Syndrome by Integrated Bioinformatics Analysis and Machine Learning.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zhou Y,
Shi W,
Zhao D,
Xiao S,
Wang K,
Wang J</span><br />
<span class="medgenPMjournal">Front Immunol</span>
2022;13:937886.
Epub 2022 Jul 4
doi: 10.3389/fimmu.2022.937886.
<span class="bold">PMID: </span><a href="/pubmed/35865542" target="_blank">35865542</a><a href="/pmc/articles/PMC9295723" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35465686">Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Diederichsen ACP,
Lindholt JS,
Möller S,
Øvrehus KA,
Auscher S,
Lambrechtsen J,
Hosbond SE,
Alan DH,
Urbonaviciene G,
Becker SW,
Fredgart MH,
Hasific S,
Folkestad L,
Gerke O,
Rasmussen LM,
Møller JE,
Mickley H,
Dahl JS</span><br />
<span class="medgenPMjournal">Circulation</span>
2022 May 3;145(18):1387-1397.
Epub 2022 Apr 25
doi: 10.1161/CIRCULATIONAHA.121.057008.
<span class="bold">PMID: </span><a href="/pubmed/35465686" target="_blank">35465686</a><a href="/pmc/articles/PMC9047644" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31488252">Why and How to Measure Aortic Valve Calcification in Patients With Aortic Stenosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pawade T,
Sheth T,
Guzzetti E,
Dweck MR,
Clavel MA</span><br />
<span class="medgenPMjournal">JACC Cardiovasc Imaging</span>
2019 Sep;12(9):1835-1848.
doi: 10.1016/j.jcmg.2019.01.045.
<span class="bold">PMID: </span><a href="/pubmed/31488252" target="_blank">31488252</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26198161">Risk Stratification in Patients With Aortic Stenosis Using Novel Imaging Approaches.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chin CW,
Pawade TA,
Newby DE,
Dweck MR</span><br />
<span class="medgenPMjournal">Circ Cardiovasc Imaging</span>
2015 Aug;8(8):e003421.
doi: 10.1161/CIRCIMAGING.115.003421.
<span class="bold">PMID: </span><a href="/pubmed/26198161" target="_blank">26198161</a><a href="/pmc/articles/PMC4539578" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23861452">Computed tomographic imaging of transcatheter aortic valve replacement for prediction and prevention of procedural complications.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Leipsic J,
Yang TH,
Min JK</span><br />
<span class="medgenPMjournal">Circ Cardiovasc Imaging</span>
2013 Jul;6(4):597-605.
doi: 10.1161/CIRCIMAGING.113.000334.
<span class="bold">PMID: </span><a href="/pubmed/23861452" target="_blank">23861452</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Aortic%20valve%20calcification%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (618)</a></div></div>
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<div class="nl"><a target="_blank" href="/pubmed/39018080">Lipoprotein(a) and Calcific Aortic Valve Stenosis Progression: A Systematic Review and Meta-Analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Arsenault BJ,
Loganath K,
Girard A,
Botezatu S,
Zheng KH,
Tzolos E,
Abdoun K,
Tastet L,
Capoulade R,
Côté N,
Craig N,
Chan KL,
Tam JW,
Teo KK,
Couture C,
Clavel MA,
Mathieu P,
Thériault S,
Stroes ESG,
Newby DE,
Tsimikas S,
Pibarot P,
Dweck MR</span><br />
<span class="medgenPMjournal">JAMA Cardiol</span>
2024 Sep 1;9(9):835-842.
doi: 10.1001/jamacardio.2024.1882.
<span class="bold">PMID: </span><a href="/pubmed/39018080" target="_blank">39018080</a><a href="/pmc/articles/PMC11255972" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37100357">Association of Aortic Valve Calcification and High Levels of Lipoprotein (a): Systematic Review and Meta-Analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Motawea KR,
Elhalag RH,
Aboelenein M,
Ibrahim N,
Swed S,
Fathy H,
Awad DM,
Belal MM,
Talaat NE,
Rozan SS,
Aiash H,
Mostafa MR</span><br />
<span class="medgenPMjournal">Curr Probl Cardiol</span>
2023 Sep;48(9):101746.
Epub 2023 Apr 24
doi: 10.1016/j.cpcardiol.2023.101746.
<span class="bold">PMID: </span><a href="/pubmed/37100357" target="_blank">37100357</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37078819">Lipoprotein(a) and calcific aortic valve disease initiation and progression: a systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pantelidis P,
Oikonomou E,
Lampsas S,
Zakynthinos GE,
Lysandrou A,
Kalogeras K,
Katsianos E,
Theofilis P,
Siasos G,
Vavuranakis MA,
Antonopoulos AS,
Tousoulis D,
Vavouranakis M</span><br />
<span class="medgenPMjournal">Cardiovasc Res</span>
2023 Jul 6;119(8):1641-1655.
doi: 10.1093/cvr/cvad062.
<span class="bold">PMID: </span><a href="/pubmed/37078819" target="_blank">37078819</a><a href="/pmc/articles/PMC10702855" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32526213">Lipoprotein(a) and calcific aortic valve stenosis: A systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Guddeti RR,
Patil S,
Ahmed A,
Sharma A,
Aboeata A,
Lavie CJ,
Alla VM</span><br />
<span class="medgenPMjournal">Prog Cardiovasc Dis</span>
2020 Jul-Aug;63(4):496-502.
Epub 2020 Jun 8
doi: 10.1016/j.pcad.2020.06.002.
<span class="bold">PMID: </span><a href="/pubmed/32526213" target="_blank">32526213</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30041902">Aortic valve calcification and risk of stroke: A systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang D,
Dai X,
Wang C,
Han K,
Wang J,
Dong Y,
Chen J,
Hou L</span><br />
<span class="medgenPMjournal">J Clin Neurosci</span>
2018 Sep;55:32-37.
Epub 2018 Jul 21
doi: 10.1016/j.jocn.2018.07.016.
<span class="bold">PMID: </span><a href="/pubmed/30041902" target="_blank">30041902</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Aortic%20valve%20calcification%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (15)</a></div></div>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Aortic%20valve%20calcification" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22aortic%20valve%20calcification%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="https://www.malacards.org/card/aortic_valve_disease_1" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&amp;query=Aortic%20valve%20calcification" target="_blank">MedlinePlus</a></li></ul></div>
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