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<!--
|
||
UID=13948
|
||
ConceptID=C0004153
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Atherosclerosis</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>13948</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0004153</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Atheroscleroses</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Atherosclerosis (38716007); Atheromatosis (38716007)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0002621">HP:0002621</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0005311" target="_blank">MONDO:0005311</a></td></tr>
|
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</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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|
||
<div class="portlet_content ln">A condition characterized by patchy atheromas or atherosclerotic plaques which develop in the walls of medium-sized and large arteries and can lead to arterial stenosis with reduced or blocked blood flow. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Atherosclerosis</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/116727" ref="tree=MeSH" title="MedGen record for Abnormality of the cardiovascular system">Abnormality of the cardiovascular system</a></span><ul><li><span class="TLline"><a href="/medgen/892473" ref="tree=MeSH" title="MedGen record for Abnormal cardiovascular system morphology">Abnormal cardiovascular system morphology</a></span><ul><li><span class="TLline"><a href="/medgen/927608" ref="tree=MeSH" title="MedGen record for Abnormal vascular morphology">Abnormal vascular morphology</a></span><ul><li><span class="TLline"><a href="/medgen/1778737" ref="tree=MeSH" title="MedGen record for Abnormal blood vessel morphology">Abnormal blood vessel morphology</a></span><ul><li><span class="TLline"><a href="/medgen/892767" ref="tree=MeSH" title="MedGen record for Abnormal systemic arterial morphology">Abnormal systemic arterial morphology</a></span><ul><li><span class="TLline"><a href="/medgen/2076" ref="tree=MeSH" title="MedGen record for Arteriosclerosis disorder">Arteriosclerosis disorder</a></span><ul><li><span class="matched_ds">Atherosclerosis</span><ul><li><span class="TLline"><a href="/medgen/376623" ref="tree=MeSH" title="MedGen record for Accelerated atherosclerosis">Accelerated atherosclerosis</a></span></li><li><span class="TLline"><a href="/medgen/510061" ref="tree=MeSH" title="MedGen record for Aortic atherosclerotic lesion">Aortic atherosclerotic lesion</a></span></li><li><span class="TLline"><a href="/medgen/1632481" ref="tree=MeSH" title="MedGen record for Atherosclerotic lesion">Atherosclerotic lesion</a></span><ul><li><span class="TLline"><a href="/medgen/1635748" ref="tree=MeSH" title="MedGen record for Type I atherosclerotic lesion">Type I atherosclerotic lesion</a></span></li><li><span class="TLline"><a href="/medgen/1632881" ref="tree=MeSH" title="MedGen record for Type II atherosclerotic lesion">Type II atherosclerotic lesion</a></span></li><li><span class="TLline"><a href="/medgen/1634853" ref="tree=MeSH" title="MedGen record for Type III atherosclerotic lesion">Type III atherosclerotic lesion</a></span></li><li><span class="TLline"><a href="/medgen/1632011" ref="tree=MeSH" title="MedGen record for Type IV atherosclerotic lesion">Type IV atherosclerotic lesion</a></span></li><li><span class="TLline"><a href="/medgen/1638264" ref="tree=MeSH" title="MedGen record for Type V atherosclerotic lesion">Type V atherosclerotic lesion</a></span></li><li><span class="TLline"><a href="/medgen/1645949" ref="tree=MeSH" title="MedGen record for Type VI atherosclerotic lesion">Type VI atherosclerotic lesion</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/40189" ref="tree=MeSH" title="MedGen record for Cerebral atherosclerosis">Cerebral atherosclerosis</a></span></li><li><span class="TLline"><a href="/medgen/3623" ref="tree=MeSH" title="MedGen record for Coronary artery atherosclerosis">Coronary artery atherosclerosis</a></span><ul><li><span class="TLline"><a href="/medgen/892352" ref="tree=MeSH" title="MedGen record for Nonocclusive coronary artery atherosclerosis">Nonocclusive coronary artery atherosclerosis</a></span></li><li><span class="TLline"><a href="/medgen/382869" ref="tree=MeSH" title="MedGen record for Post-angioplasty coronary artery restenosis">Post-angioplasty coronary artery restenosis</a></span></li><li><span class="TLline"><a href="/medgen/356830" ref="tree=MeSH" title="MedGen record for Premature coronary artery atherosclerosis">Premature coronary artery atherosclerosis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/569155" ref="tree=MeSH" title="MedGen record for Fatty streak">Fatty streak</a></span></li><li><span class="TLline"><a href="/medgen/924121" ref="tree=MeSH" title="MedGen record for Foam cells">Foam cells</a></span><ul><li><span class="TLline"><a href="/medgen/1813072" ref="tree=MeSH" title="MedGen record for CNS foam cells">CNS foam cells</a></span></li><li><span class="TLline"><a href="/medgen/871121" ref="tree=MeSH" title="MedGen record for Foam cells with lamellar inclusion bodies">Foam cells with lamellar inclusion bodies</a></span></li><li><span class="TLline"><a href="/medgen/1814130" ref="tree=MeSH" title="MedGen record for Hepatic foam cells">Hepatic foam cells</a></span></li><li><span class="TLline"><a href="/medgen/1717883" ref="tree=MeSH" title="MedGen record for Renal glomerular foam cells">Renal glomerular foam cells</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/4866" ref="tree=MeSH" title="MedGen record for Generalized atherosclerosis">Generalized atherosclerosis</a></span></li><li><span class="TLline"><a href="/medgen/352846" ref="tree=MeSH" title="MedGen record for Peripheral arterial disease">Peripheral arterial disease</a></span><ul><li><span class="TLline"><a href="/medgen/1782264" ref="tree=MeSH" title="MedGen record for Rest limb pain">Rest limb pain</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/867292" ref="tree=MeSH" title="MedGen record for Precocious atherosclerosis">Precocious atherosclerosis</a></span></li><li><span class="TLline"><a href="/medgen/1393553" ref="tree=MeSH" title="MedGen record for Thin-cap fibroatheroma">Thin-cap fibroatheroma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_52644"><div><strong>Tangier disease</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>52644</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0039292</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Tangier disease is characterized by severe deficiency or absence of high-density lipoprotein (HDL) in the circulation resulting in tissue accumulation of cholesteryl esters throughout the body, particularly in the reticuloendothelial system. The major clinical signs of Tangier disease include hyperplastic yellow-orange tonsils, hepatosplenomegaly, and peripheral neuropathy, which may be either relapsing-remitting or chronic progressive in nature. Rarer complications may include corneal opacities that typically do not affect vision, premature atherosclerotic coronary artery disease occurring in the sixth and seventh decades of life (not usually before age 40 years), and mild hematologic manifestations, such as mild thrombocytopenia, reticulocytosis, stomatocytosis, or hemolytic anemia. The clinical expression of Tangier disease is variable, with some affected individuals only showing biochemical perturbations.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/52644">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_78675"><div><strong>Alstrom syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>78675</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0268425</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Alström syndrome is characterized by cone-rod dystrophy, obesity, progressive bilateral sensorineural hearing impairment, acute infantile-onset cardiomyopathy and/or adolescent- or adult-onset restrictive cardiomyopathy, insulin resistance / type 2 diabetes mellitus (T2DM), nonalcoholic fatty liver disease (NAFLD), and chronic progressive kidney disease. Cone-rod dystrophy presents as progressive visual impairment, photophobia, and nystagmus usually starting between birth and age 15 months. Many individuals lose all perception of light by the end of the second decade, but a minority retain the ability to read large print into the third decade. Children usually have normal birth weight but develop truncal obesity during their first year. Sensorineural hearing loss presents in the first decade in as many as 70% of individuals and may progress to the severe or moderately severe range (40-70 db) by the end of the first to second decade. Insulin resistance is typically accompanied by the skin changes of acanthosis nigricans, and proceeds to T2DM in the majority by the third decade. Nearly all demonstrate hypertriglyceridemia. Other findings can include endocrine abnormalities (hypothyroidism, hypogonadotropic hypogonadism in males, and hyperandrogenism in females), urologic dysfunction / detrusor instability, progressive decrease in renal function, and hepatic disease (ranging from elevated transaminases to steatohepatitis/NAFLD). Approximately 20% of affected individuals have delay in early developmental milestones, most commonly in gross and fine motor skills. About 30% have a learning disability. Cognitive impairment (IQ <70) is very rare. Wide clinical variability is observed among affected individuals, even within the same family.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/78675">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_354526"><div><strong>Familial partial lipodystrophy, Dunnigan type</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>354526</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1720860</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial partial lipodystrophy (FPLD) is a metabolic disorder characterized by abnormal subcutaneous adipose tissue distribution beginning in late childhood or early adult life. Affected individuals gradually lose fat from the upper and lower extremities and the gluteal and truncal regions, resulting in a muscular appearance with prominent superficial veins. In some patients, adipose tissue accumulates on the face and neck, causing a double chin, fat neck, or cushingoid appearance. Metabolic abnormalities include insulin-resistant diabetes mellitus with acanthosis nigricans and hypertriglyceridemia; hirsutism and menstrual abnormalities occur infrequently. Familial partial lipodystrophy may also be referred to as lipoatrophic diabetes mellitus, but the essential feature is loss of subcutaneous fat (review by Garg, 2004). The disorder may be misdiagnosed as Cushing disease (see 219080) (Kobberling and Dunnigan, 1986; Garg, 2004). Genetic Heterogeneity of Familial Partial Lipodystrophy Familial partial lipodystrophy is a clinically and genetically heterogeneous disorder. Types 1 and 2 were originally described as clinical subtypes: type 1 (FPLD1; 608600), characterized by loss of subcutaneous fat confined to the limbs (Kobberling et al., 1975), and FPLD2, characterized by loss of subcutaneous fat from the limbs and trunk (Dunnigan et al., 1974; Kobberling and Dunnigan, 1986). No genetic basis for FPLD1 has yet been delineated. FPLD3 (604367) is caused by mutation in the PPARG gene (601487) on chromosome 3p25; FPLD4 (613877) is caused by mutation in the PLIN1 gene (170290) on chromosome 15q26; FPLD5 (615238) is caused by mutation in the CIDEC gene (612120) on chromosome 3p25; FPLD6 (615980) is caused by mutation in the LIPE gene (151750) on chromosome 19q13; FPLD7 (606721) is caused by mutation in the CAV1 gene (601047) on chromosome 7q31; FPLD8 (620679), caused by mutation in the ADRA2A gene (104210) on chromosome 10q25; and FPLD9 (620683), caused by mutation in the PLAAT3 gene (613867) on chromosome 11q12.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/354526">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_332067"><div><strong>Body skin hyperlaxity due to vitamin K-dependent coagulation factor deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>332067</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1835813</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Body skin hyperlaxity due to vitamin K-dependent coagulation factor deficiency is a very rare genetic skin disease characterized by severe skin laxity affecting the trunk and limbs.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/332067">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_400313"><div><strong>Hypercholesterolemia, familial, 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>400313</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1863512</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial hypercholesterolemia (FH) is characterized by significantly elevated low-density lipoprotein cholesterol (LDL-C) that leads to atherosclerotic plaque deposition in the coronary arteries and proximal aorta at an early age and increases the risk of premature cardiovascular events such as angina and myocardial infarction; stroke occurs more rarely. Xanthomas (cholesterol deposits in tendons) may be visible in the Achilles tendons or tendons of the hands and worsen with age as a result of extremely high cholesterol levels. Xanthelasmas (yellowish, waxy deposits) can occur around the eyelids. Individuals with FH may develop corneal arcus (white, gray, or blue opaque ring in the corneal margin as a result of cholesterol deposition) at a younger age than those without FH. Individuals with a more severe phenotype, often as a result of biallelic variants, can present with very significant elevations in LDL-C (>500 mg/dL), early-onset coronary artery disease (CAD; presenting as early as childhood in some), and calcific aortic valve disease.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/400313">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_462796"><div><strong>Nestor-Guillermo progeria syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462796</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3151446</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Nestor-Guillermo progeria syndrome (NGPS) is an autosomal recessive disorder characterized by lipoatrophy, osteoporosis, and very severe osteolysis. Patients have no cardiovascular impairment, diabetes mellitus, or hypertriglyceridemia, but suffer profound skeletal abnormalities that affect their quality of life. Onset is after 2 years of age, and lifespan is relatively long (summary by Cabanillas et al., 2011).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462796">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_78675" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Alstrom syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_332067" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Body skin hyperlaxity due to vitamin K-dependent coagulation factor deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_354526" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial partial lipodystrophy, Dunnigan type</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_400313" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypercholesterolemia, familial, 4</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462796" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Nestor-Guillermo progeria syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_52644" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Tangier disease</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37471501">2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Virani SS,
|
||
Newby LK,
|
||
Arnold SV,
|
||
Bittner V,
|
||
Brewer LC,
|
||
Demeter SH,
|
||
Dixon DL,
|
||
Fearon WF,
|
||
Hess B,
|
||
Johnson HM,
|
||
Kazi DS,
|
||
Kolte D,
|
||
Kumbhani DJ,
|
||
LoFaso J,
|
||
Mahtta D,
|
||
Mark DB,
|
||
Minissian M,
|
||
Navar AM,
|
||
Patel AR,
|
||
Piano MR,
|
||
Rodriguez F,
|
||
Talbot AW,
|
||
Taqueti VR,
|
||
Thomas RJ,
|
||
van Diepen S,
|
||
Wiggins B,
|
||
Williams MS;
|
||
Peer Review Committee Members</span><br />
|
||
<span class="medgenPMjournal">Circulation</span>
|
||
2023 Aug 29;148(9):e9-e119.
|
||
Epub 2023 Jul 20
|
||
doi: 10.1161/CIR.0000000000001168.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37471501" target="_blank">37471501</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31838973">Diagnosis and Treatment of Heterozygous Familial Hypercholesterolemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">McGowan MP,
|
||
Hosseini Dehkordi SH,
|
||
Moriarty PM,
|
||
Duell PB</span><br />
|
||
<span class="medgenPMjournal">J Am Heart Assoc</span>
|
||
2019 Dec 17;8(24):e013225.
|
||
Epub 2019 Dec 16
|
||
doi: 10.1161/JAHA.119.013225.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31838973" target="_blank">31838973</a><a href="/pmc/articles/PMC6951065" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30879355">2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Arnett DK,
|
||
Blumenthal RS,
|
||
Albert MA,
|
||
Buroker AB,
|
||
Goldberger ZD,
|
||
Hahn EJ,
|
||
Himmelfarb CD,
|
||
Khera A,
|
||
Lloyd-Jones D,
|
||
McEvoy JW,
|
||
Michos ED,
|
||
Miedema MD,
|
||
Muñoz D,
|
||
Smith SC Jr,
|
||
Virani SS,
|
||
Williams KA Sr,
|
||
Yeboah J,
|
||
Ziaeian B</span><br />
|
||
<span class="medgenPMjournal">Circulation</span>
|
||
2019 Sep 10;140(11):e596-e646.
|
||
Epub 2019 Mar 17
|
||
doi: 10.1161/CIR.0000000000000678.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30879355" target="_blank">30879355</a><a href="/pmc/articles/PMC7734661" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22atherosclerosis%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (3501)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36831189">The Role of Macrophages in the Pathogenesis of Atherosclerosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Blagov AV,
|
||
Markin AM,
|
||
Bogatyreva AI,
|
||
Tolstik TV,
|
||
Sukhorukov VN,
|
||
Orekhov AN</span><br />
|
||
<span class="medgenPMjournal">Cells</span>
|
||
2023 Feb 5;12(4)
|
||
doi: 10.3390/cells12040522.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36831189" target="_blank">36831189</a><a href="/pmc/articles/PMC9954519" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35328769">Pathophysiology of Atherosclerosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jebari-Benslaiman S,
|
||
Galicia-García U,
|
||
Larrea-Sebal A,
|
||
Olaetxea JR,
|
||
Alloza I,
|
||
Vandenbroeck K,
|
||
Benito-Vicente A,
|
||
Martín C</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2022 Mar 20;23(6)
|
||
doi: 10.3390/ijms23063346.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35328769" target="_blank">35328769</a><a href="/pmc/articles/PMC8954705" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35076127">Atherosclerosis: Known and unknown.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fan J,
|
||
Watanabe T</span><br />
|
||
<span class="medgenPMjournal">Pathol Int</span>
|
||
2022 Mar;72(3):151-160.
|
||
Epub 2022 Jan 25
|
||
doi: 10.1111/pin.13202.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35076127" target="_blank">35076127</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33883728">The changing landscape of atherosclerosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Libby P</span><br />
|
||
<span class="medgenPMjournal">Nature</span>
|
||
2021 Apr;592(7855):524-533.
|
||
Epub 2021 Apr 21
|
||
doi: 10.1038/s41586-021-03392-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33883728" target="_blank">33883728</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32571617">Atherosclerosis and inflammation. New therapeutic approaches.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pedro-Botet J,
|
||
Climent E,
|
||
Benaiges D</span><br />
|
||
<span class="medgenPMjournal">Med Clin (Barc)</span>
|
||
2020 Sep 25;155(6):256-262.
|
||
Epub 2020 Jun 20
|
||
doi: 10.1016/j.medcli.2020.04.024.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32571617" target="_blank">32571617</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Atherosclerosis%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (68875)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37897322">Nanomedicine for Diagnosis and Treatment of Atherosclerosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cheng J,
|
||
Huang H,
|
||
Chen Y,
|
||
Wu R</span><br />
|
||
<span class="medgenPMjournal">Adv Sci (Weinh)</span>
|
||
2023 Dec;10(36):e2304294.
|
||
Epub 2023 Oct 28
|
||
doi: 10.1002/advs.202304294.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37897322" target="_blank">37897322</a><a href="/pmc/articles/PMC10754137" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37039406">Diagnosis and Management of Large Artery Atherosclerosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chaturvedi S</span><br />
|
||
<span class="medgenPMjournal">Continuum (Minneap Minn)</span>
|
||
2023 Apr 1;29(2):486-500.
|
||
doi: 10.1212/CON.0000000000001212.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37039406" target="_blank">37039406</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36012202">New Progress in Early Diagnosis of Atherosclerosis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Meng H,
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<div class="nl"><a target="_blank" href="/pubmed/34229346">Dietary recommendations for prevention of atherosclerosis.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/31362692">Biomechanical Forces and Atherosclerosis: From Mechanism to Diagnosis and Treatment.</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Atherosclerosis%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (31006)</a></div><h3 class="subhead">Therapy</h3>
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<div class="nl"><a target="_blank" href="/pubmed/39357937">Influence of Subclinical Atherosclerosis Burden and Progression on Mortality.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Fuster V,
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<div class="nl"><a target="_blank" href="/pubmed/38824844">Advancements in risk stratification and management strategies in primary cardiovascular prevention.</a></div>
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<span class="bold">PMID: </span><a href="/pubmed/38824844" target="_blank">38824844</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">McClenaghan L,
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<span class="bold">PMID: </span><a href="/pubmed/34462808" target="_blank">34462808</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Alexander Y,
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Osto E,
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<div class="nl"><a target="_blank" href="/pubmed/28794054">Cardiovascular Event Prediction by Machine Learning: The Multi-Ethnic Study of Atherosclerosis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Ambale-Venkatesh B,
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Yang X,
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Wu CO,
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Liu K,
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Hundley WG,
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McClelland R,
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<span class="bold">PMID: </span><a href="/pubmed/28794054" target="_blank">28794054</a><a href="/pmc/articles/PMC5640485" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Atherosclerosis%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (38073)</a></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">
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<div class="nl"><a target="_blank" href="/pubmed/33155924">Cardiovascular Changes in Menopause.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Nair AR,
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Pillai AJ,
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Nair N</span><br />
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2021;17(4):e230421187681.
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doi: 10.2174/1573403X16666201106141811.
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<span class="bold">PMID: </span><a href="/pubmed/33155924" target="_blank">33155924</a><a href="/pmc/articles/PMC8762155" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/32353319">Global and regional prevalence, burden, and risk factors for carotid atherosclerosis: a systematic review, meta-analysis, and modelling study.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Song P,
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Fang Z,
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Wang H,
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Cai Y,
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Rahimi K,
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Zhu Y,
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Fowkes FGR,
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Fowkes FJI,
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Rudan I</span><br />
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<span class="medgenPMjournal">Lancet Glob Health</span>
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2020 May;8(5):e721-e729.
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<span class="bold">PMID: </span><a href="/pubmed/32353319" target="_blank">32353319</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/30702994">Cholesterol-Lowering Agents.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Rosenson RS,
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Hegele RA,
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Koenig W</span><br />
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<span class="medgenPMjournal">Circ Res</span>
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<span class="bold">PMID: </span><a href="/pubmed/30702994" target="_blank">30702994</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/30439455">Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Xu S,
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Kamato D,
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Little PJ,
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Nakagawa S,
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Epub 2018 Nov 13
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<span class="bold">PMID: </span><a href="/pubmed/30439455" target="_blank">30439455</a><a href="/pmc/articles/PMC6450782" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/26818921">Nondipping pattern and carotid atherosclerosis: a systematic review and meta-analysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Cuspidi C,
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Sala C,
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Tadic M,
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Gherbesi E,
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<span class="bold">PMID: </span><a href="/pubmed/26818921" target="_blank">26818921</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Atherosclerosis%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1134)</a></div></div>
|
||
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|
||
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|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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