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<meta name="keywords" content="C4476570, finding, low brain creatine phosphate, reduced brain creatine level by magnetic resonance spectroscopy, reduced brain creatine level by mrs, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A decrease in the level of creatine in the brain identified by magnetic resonance spectroscopy (MRS)." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=1369880
|
||
ConceptID=C4476570
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Reduced brain creatine level by MRS</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1369880</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4476570</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Low brain creatine phosphate; Reduced brain creatine level by magnetic resonance spectroscopy</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0025051">HP:0025051</a></td></tr>
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</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">A decrease in the level of creatine in the brain identified by magnetic resonance spectroscopy (MRS). [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Reduced brain creatine level by MRS</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/474891" ref="tree=MeSH" title="MedGen record for Congenital Systemic Disorder">Congenital Systemic Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/105425" ref="tree=MeSH" title="MedGen record for Abnormality of the nervous system">Abnormality of the nervous system</a></span><ul><li><span class="TLline"><a href="/medgen/868417" ref="tree=MeSH" title="MedGen record for Abnormal nervous system physiology">Abnormal nervous system physiology</a></span><ul><li><span class="TLline"><a href="/medgen/751376" ref="tree=MeSH" title="MedGen record for Brain imaging abnormality">Brain imaging abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/868370" ref="tree=MeSH" title="MedGen record for Abnormal metabolic brain imaging by MRS">Abnormal metabolic brain imaging by MRS</a></span><ul><li><span class="TLline"><a href="/medgen/1370529" ref="tree=MeSH" title="MedGen record for Abnormal brain creatine level by MRS">Abnormal brain creatine level by MRS</a></span><ul><li><span class="matched_ds">Reduced brain creatine level by MRS</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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||
<div class="divPopper rprt" id="rdis_154356"><div><strong>Deficiency of guanidinoacetate methyltransferase</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>154356</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0574080</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The creatine deficiency disorders (CDDs), inborn errors of creatine metabolism and transport, comprise three disorders: the creatine biosynthesis disorders guanidinoacetate methyltransferase (GAMT) deficiency and L-arginine:glycine amidinotransferase (AGAT) deficiency; and creatine transporter (CRTR) deficiency. Developmental delay and cognitive dysfunction or intellectual disability and speech-language disorder are common to all three CDDs. Onset of clinical manifestations of GAMT deficiency (reported in ~130 individuals) is between ages three months and two years; in addition to developmental delays, the majority of individuals have epilepsy and develop a behavior disorder (e.g., hyperactivity, autism, or self-injurious behavior), and about 30% have movement disorder. AGAT deficiency has been reported in 16 individuals; none have had epilepsy or movement disorders. Clinical findings of CRTR deficiency in affected males (reported in ~130 individuals) in addition to developmental delays include epilepsy (variable seizure types and may be intractable) and behavior disorders (e.g., attention deficit and/or hyperactivity, autistic features, impulsivity, social anxiety), hypotonia, and (less commonly) a movement disorder. Poor weight gain with constipation and prolonged QTc on EKG have been reported. While mild-to-moderate intellectual disability is commonly observed up to age four years, the majority of adult males with CRTR deficiency have been reported to have severe intellectual disability. Females heterozygous for CRTR deficiency are typically either asymptomatic or have mild intellectual disability, although a more severe phenotype resembling the male phenotype has been reported.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/154356">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_337451"><div><strong>Creatine transporter deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>337451</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C1845862</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The creatine deficiency disorders (CDDs), inborn errors of creatine metabolism and transport, comprise three disorders: the creatine biosynthesis disorders guanidinoacetate methyltransferase (GAMT) deficiency and L-arginine:glycine amidinotransferase (AGAT) deficiency; and creatine transporter (CRTR) deficiency. Developmental delay and cognitive dysfunction or intellectual disability and speech-language disorder are common to all three CDDs. Onset of clinical manifestations of GAMT deficiency (reported in ~130 individuals) is between ages three months and two years; in addition to developmental delays, the majority of individuals have epilepsy and develop a behavior disorder (e.g., hyperactivity, autism, or self-injurious behavior), and about 30% have movement disorder. AGAT deficiency has been reported in 16 individuals; none have had epilepsy or movement disorders. Clinical findings of CRTR deficiency in affected males (reported in ~130 individuals) in addition to developmental delays include epilepsy (variable seizure types and may be intractable) and behavior disorders (e.g., attention deficit and/or hyperactivity, autistic features, impulsivity, social anxiety), hypotonia, and (less commonly) a movement disorder. Poor weight gain with constipation and prolonged QTc on EKG have been reported. While mild-to-moderate intellectual disability is commonly observed up to age four years, the majority of adult males with CRTR deficiency have been reported to have severe intellectual disability. Females heterozygous for CRTR deficiency are typically either asymptomatic or have mild intellectual disability, although a more severe phenotype resembling the male phenotype has been reported.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/337451">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_436367"><div><strong>Arginine:glycine amidinotransferase deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>436367</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2675179</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The creatine deficiency disorders (CDDs), inborn errors of creatine metabolism and transport, comprise three disorders: the creatine biosynthesis disorders guanidinoacetate methyltransferase (GAMT) deficiency and L-arginine:glycine amidinotransferase (AGAT) deficiency; and creatine transporter (CRTR) deficiency. Developmental delay and cognitive dysfunction or intellectual disability and speech-language disorder are common to all three CDDs. Onset of clinical manifestations of GAMT deficiency (reported in ~130 individuals) is between ages three months and two years; in addition to developmental delays, the majority of individuals have epilepsy and develop a behavior disorder (e.g., hyperactivity, autism, or self-injurious behavior), and about 30% have movement disorder. AGAT deficiency has been reported in 16 individuals; none have had epilepsy or movement disorders. Clinical findings of CRTR deficiency in affected males (reported in ~130 individuals) in addition to developmental delays include epilepsy (variable seizure types and may be intractable) and behavior disorders (e.g., attention deficit and/or hyperactivity, autistic features, impulsivity, social anxiety), hypotonia, and (less commonly) a movement disorder. Poor weight gain with constipation and prolonged QTc on EKG have been reported. While mild-to-moderate intellectual disability is commonly observed up to age four years, the majority of adult males with CRTR deficiency have been reported to have severe intellectual disability. Females heterozygous for CRTR deficiency are typically either asymptomatic or have mild intellectual disability, although a more severe phenotype resembling the male phenotype has been reported.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/436367">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_436367" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Arginine:glycine amidinotransferase deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_337451" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Creatine transporter deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_154356" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Deficiency of guanidinoacetate methyltransferase</a></div></div>
|
||
</div>
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||
|
||
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/27327561">Neurochemical correlates of rapid treatment response to electroconvulsive therapy in patients with major depression.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Njau S,
|
||
Joshi SH,
|
||
Espinoza R,
|
||
Leaver AM,
|
||
Vasavada M,
|
||
Marquina A,
|
||
Woods RP,
|
||
Narr KL</span><br />
|
||
<span class="medgenPMjournal">J Psychiatry Neurosci</span>
|
||
2017 Jan;42(1):6-16.
|
||
doi: 10.1503/jpn.150177.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27327561" target="_blank">27327561</a><a href="/pmc/articles/PMC5373714" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27603381">Monitoring interferon β treatment response with magnetic resonance spectroscopy in relapsing remitting multiple sclerosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yetkin MF,
|
||
Mirza M,
|
||
Dönmez H</span><br />
|
||
<span class="medgenPMjournal">Medicine (Baltimore)</span>
|
||
2016 Sep;95(36):e4782.
|
||
doi: 10.1097/MD.0000000000004782.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27603381" target="_blank">27603381</a><a href="/pmc/articles/PMC5023904" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18652076">Cerebral creatine deficiency syndromes: clinical aspects, treatment and pathophysiology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stockler S,
|
||
Schutz PW,
|
||
Salomons GS</span><br />
|
||
<span class="medgenPMjournal">Subcell Biochem</span>
|
||
2007;46:149-66.
|
||
doi: 10.1007/978-1-4020-6486-9_8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18652076" target="_blank">18652076</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(reduced%20brain%20creatine%20level%20by%20mrs)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (4)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37787109">Longitudinal Metabolite Changes in Progressive Multiple Sclerosis: A Study of 3 Potential Neuroprotective Treatments.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">John NA,
|
||
Solanky BS,
|
||
De Angelis F,
|
||
Parker RA,
|
||
Weir CJ,
|
||
Stutters J,
|
||
Carrasco FP,
|
||
Schneider T,
|
||
Doshi A,
|
||
Calvi A,
|
||
Williams T,
|
||
Plantone D,
|
||
Monteverdi A,
|
||
MacManus D,
|
||
Marshall I,
|
||
Barkhof F,
|
||
Gandini Wheeler-Kingshott CAM,
|
||
Chataway J;
|
||
MS‐SMART Investigators</span><br />
|
||
<span class="medgenPMjournal">J Magn Reson Imaging</span>
|
||
2024 Jun;59(6):2192-2201.
|
||
Epub 2023 Oct 3
|
||
doi: 10.1002/jmri.29017.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37787109" target="_blank">37787109</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31795972">Cortical GABA in migraine with aura -an ultrashort echo magnetic resonance spectroscopy study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stærmose TG,
|
||
Knudsen MK,
|
||
Kasch H,
|
||
Blicher JU</span><br />
|
||
<span class="medgenPMjournal">J Headache Pain</span>
|
||
2019 Dec 3;20(1):110.
|
||
doi: 10.1186/s10194-019-1059-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31795972" target="_blank">31795972</a><a href="/pmc/articles/PMC6889606" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30513795">The Effect of a High-Dose Vitamin B Multivitamin Supplement on the Relationship between Brain Metabolism and Blood Biomarkers of Oxidative Stress: A Randomized Control Trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ford TC,
|
||
Downey LA,
|
||
Simpson T,
|
||
McPhee G,
|
||
Oliver C,
|
||
Stough C</span><br />
|
||
<span class="medgenPMjournal">Nutrients</span>
|
||
2018 Dec 1;10(12)
|
||
doi: 10.3390/nu10121860.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30513795" target="_blank">30513795</a><a href="/pmc/articles/PMC6316433" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23370056">Decreased left perisylvian GABA concentration in children with autism and unaffected siblings.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rojas DC,
|
||
Singel D,
|
||
Steinmetz S,
|
||
Hepburn S,
|
||
Brown MS</span><br />
|
||
<span class="medgenPMjournal">Neuroimage</span>
|
||
2014 Feb 1;86:28-34.
|
||
Epub 2013 Jan 28
|
||
doi: 10.1016/j.neuroimage.2013.01.045.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23370056" target="_blank">23370056</a><a href="/pmc/articles/PMC3773530" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15953489">Decreased prefrontal Myo-inositol in major depressive disorder.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Coupland NJ,
|
||
Ogilvie CJ,
|
||
Hegadoren KM,
|
||
Seres P,
|
||
Hanstock CC,
|
||
Allen PS</span><br />
|
||
<span class="medgenPMjournal">Biol Psychiatry</span>
|
||
2005 Jun 15;57(12):1526-34.
|
||
doi: 10.1016/j.biopsych.2005.02.027.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15953489" target="_blank">15953489</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Reduced%20brain%20creatine%20level%20by%20MRS%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (96)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37708665">X-linked creatine transporter (SLC6A8) deficiency in females: Difficult to recognize, but a potentially treatable disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mejdahl Nielsen M,
|
||
Petersen ET,
|
||
Fenger CD,
|
||
Ørngreen MC,
|
||
Siebner HR,
|
||
Boer VO,
|
||
Považan M,
|
||
Lund A,
|
||
Grønborg SW,
|
||
Hammer TB</span><br />
|
||
<span class="medgenPMjournal">Mol Genet Metab</span>
|
||
2023 Nov;140(3):107694.
|
||
Epub 2023 Aug 30
|
||
doi: 10.1016/j.ymgme.2023.107694.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37708665" target="_blank">37708665</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37406595">Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yang YS,
|
||
Smucny J,
|
||
Zhang H,
|
||
Maddock RJ</span><br />
|
||
<span class="medgenPMjournal">Neuroimage Clin</span>
|
||
2023;39:103461.
|
||
Epub 2023 Jun 27
|
||
doi: 10.1016/j.nicl.2023.103461.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37406595" target="_blank">37406595</a><a href="/pmc/articles/PMC10509531" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36508896">Brain total creatine differs between primary progressive aphasia (PPA) subtypes and correlates with disease severity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hupfeld KE,
|
||
Zöllner HJ,
|
||
Oeltzschner G,
|
||
Hyatt HW,
|
||
Herrmann O,
|
||
Gallegos J,
|
||
Hui SCN,
|
||
Harris AD,
|
||
Edden RAE,
|
||
Tsapkini K</span><br />
|
||
<span class="medgenPMjournal">Neurobiol Aging</span>
|
||
2023 Feb;122:65-75.
|
||
Epub 2022 Nov 17
|
||
doi: 10.1016/j.neurobiolaging.2022.11.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36508896" target="_blank">36508896</a><a href="/pmc/articles/PMC9839619" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33851253">Usefulness of magnetic resonance spectroscopy in mesial temporal sclerosis: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fernández-Vega N,
|
||
Ramos-Rodriguez JR,
|
||
Alfaro F,
|
||
Barbancho MÁ,
|
||
García-Casares N</span><br />
|
||
<span class="medgenPMjournal">Neuroradiology</span>
|
||
2021 Sep;63(9):1395-1405.
|
||
Epub 2021 Apr 13
|
||
doi: 10.1007/s00234-021-02704-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33851253" target="_blank">33851253</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26402632">Magnetic Resonance Spectroscopy in Alzheimer's Disease: Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang H,
|
||
Tan L,
|
||
Wang HF,
|
||
Liu Y,
|
||
Yin RH,
|
||
Wang WY,
|
||
Chang XL,
|
||
Jiang T,
|
||
Yu JT</span><br />
|
||
<span class="medgenPMjournal">J Alzheimers Dis</span>
|
||
2015;46(4):1049-70.
|
||
doi: 10.3233/JAD-143225.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26402632" target="_blank">26402632</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Reduced%20brain%20creatine%20level%20by%20MRS%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (80)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37787109">Longitudinal Metabolite Changes in Progressive Multiple Sclerosis: A Study of 3 Potential Neuroprotective Treatments.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">John NA,
|
||
Solanky BS,
|
||
De Angelis F,
|
||
Parker RA,
|
||
Weir CJ,
|
||
Stutters J,
|
||
Carrasco FP,
|
||
Schneider T,
|
||
Doshi A,
|
||
Calvi A,
|
||
Williams T,
|
||
Plantone D,
|
||
Monteverdi A,
|
||
MacManus D,
|
||
Marshall I,
|
||
Barkhof F,
|
||
Gandini Wheeler-Kingshott CAM,
|
||
Chataway J;
|
||
MS‐SMART Investigators</span><br />
|
||
<span class="medgenPMjournal">J Magn Reson Imaging</span>
|
||
2024 Jun;59(6):2192-2201.
|
||
Epub 2023 Oct 3
|
||
doi: 10.1002/jmri.29017.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37787109" target="_blank">37787109</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30513795">The Effect of a High-Dose Vitamin B Multivitamin Supplement on the Relationship between Brain Metabolism and Blood Biomarkers of Oxidative Stress: A Randomized Control Trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ford TC,
|
||
Downey LA,
|
||
Simpson T,
|
||
McPhee G,
|
||
Oliver C,
|
||
Stough C</span><br />
|
||
<span class="medgenPMjournal">Nutrients</span>
|
||
2018 Dec 1;10(12)
|
||
doi: 10.3390/nu10121860.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30513795" target="_blank">30513795</a><a href="/pmc/articles/PMC6316433" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25668581">Randomized trial of erhuangfang for relapsing multiple sclerosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhou L,
|
||
Fan Y</span><br />
|
||
<span class="medgenPMjournal">Neurol Res</span>
|
||
2015 Jul;37(7):633-7.
|
||
Epub 2015 Feb 10
|
||
doi: 10.1179/1743132815Y.0000000011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25668581" target="_blank">25668581</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12931205">Affective disorders, antidepressant drugs and brain metabolism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Moretti A,
|
||
Gorini A,
|
||
Villa RF</span><br />
|
||
<span class="medgenPMjournal">Mol Psychiatry</span>
|
||
2003 Sep;8(9):773-85.
|
||
doi: 10.1038/sj.mp.4001353.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12931205" target="_blank">12931205</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12662128">Magnetic resonance spectroscopy studies of GABA in neuropsychiatric disorders.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chang L,
|
||
Cloak CC,
|
||
Ernst T</span><br />
|
||
<span class="medgenPMjournal">J Clin Psychiatry</span>
|
||
2003;64 Suppl 3:7-14.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12662128" target="_blank">12662128</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Reduced%20brain%20creatine%20level%20by%20MRS%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (39)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38427192">Magnetic Resonance Spectroscopy (MRS) in Alzheimer's Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sheikh-Bahaei N,
|
||
Chen M,
|
||
Pappas I</span><br />
|
||
<span class="medgenPMjournal">Methods Mol Biol</span>
|
||
2024;2785:115-142.
|
||
doi: 10.1007/978-1-0716-3774-6_9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38427192" target="_blank">38427192</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36508896">Brain total creatine differs between primary progressive aphasia (PPA) subtypes and correlates with disease severity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hupfeld KE,
|
||
Zöllner HJ,
|
||
Oeltzschner G,
|
||
Hyatt HW,
|
||
Herrmann O,
|
||
Gallegos J,
|
||
Hui SCN,
|
||
Harris AD,
|
||
Edden RAE,
|
||
Tsapkini K</span><br />
|
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<div class="nl"><a target="_blank" href="/pubmed/23281189">Spatial variability and changes of metabolite concentrations in the cortico-spinal tract in multiple sclerosis using coronal CSI.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Tur C,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Reduced%20brain%20creatine%20level%20by%20MRS%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (24)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/38427192">Magnetic Resonance Spectroscopy (MRS) in Alzheimer's Disease.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Sheikh-Bahaei N,
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<div class="portlet_content ln"><span class="medgenPMauthor">John NA,
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Solanky BS,
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De Angelis F,
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Parker RA,
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Weir CJ,
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Stutters J,
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Carrasco FP,
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Schneider T,
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Doshi A,
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Calvi A,
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Plantone D,
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Monteverdi A,
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Marshall I,
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Barkhof F,
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Gandini Wheeler-Kingshott CAM,
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Chataway J;
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2024 Jun;59(6):2192-2201.
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Epub 2023 Oct 3
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doi: 10.1002/jmri.29017.
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<span class="bold">PMID: </span><a href="/pubmed/37787109" target="_blank">37787109</a></div>
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||
<div class="nl"><a target="_blank" href="/pubmed/37406595">Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Yang YS,
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Smucny J,
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Zhang H,
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Maddock RJ</span><br />
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<span class="medgenPMjournal">Neuroimage Clin</span>
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Epub 2023 Jun 27
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doi: 10.1016/j.nicl.2023.103461.
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<span class="bold">PMID: </span><a href="/pubmed/37406595" target="_blank">37406595</a><a href="/pmc/articles/PMC10509531" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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||
<div class="nl"><a target="_blank" href="/pubmed/36508896">Brain total creatine differs between primary progressive aphasia (PPA) subtypes and correlates with disease severity.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Hupfeld KE,
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Zöllner HJ,
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Oeltzschner G,
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Hyatt HW,
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Herrmann O,
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Gallegos J,
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Hui SCN,
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Harris AD,
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Edden RAE,
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Tsapkini K</span><br />
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<span class="medgenPMjournal">Neurobiol Aging</span>
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2023 Feb;122:65-75.
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||
Epub 2022 Nov 17
|
||
doi: 10.1016/j.neurobiolaging.2022.11.006.
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||
<span class="bold">PMID: </span><a href="/pubmed/36508896" target="_blank">36508896</a><a href="/pmc/articles/PMC9839619" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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|
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<div class="nl"><a target="_blank" href="/pubmed/26402632">Magnetic Resonance Spectroscopy in Alzheimer's Disease: Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang H,
|
||
Tan L,
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||
Wang HF,
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||
Liu Y,
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||
Yin RH,
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||
Wang WY,
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Chang XL,
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||
Jiang T,
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Yu JT</span><br />
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<span class="medgenPMjournal">J Alzheimers Dis</span>
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2015;46(4):1049-70.
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doi: 10.3233/JAD-143225.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26402632" target="_blank">26402632</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Reduced%20brain%20creatine%20level%20by%20MRS%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (71)</a></div></div>
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<div class="nl"><a target="_blank" href="/pubmed/40012049">Fetal brain development in fetal growth restriction using MRI: a systematic review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Meijerink L,
|
||
van Ooijen IM,
|
||
Alderliesten T,
|
||
Terstappen F,
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||
Benders MJNL,
|
||
Bekker MN</span><br />
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<span class="medgenPMjournal">BMC Pregnancy Childbirth</span>
|
||
2025 Feb 26;25(1):208.
|
||
doi: 10.1186/s12884-024-07124-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/40012049" target="_blank">40012049</a><a href="/pmc/articles/PMC11863776" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/33851253">Usefulness of magnetic resonance spectroscopy in mesial temporal sclerosis: a systematic review.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Fernández-Vega N,
|
||
Ramos-Rodriguez JR,
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||
Alfaro F,
|
||
Barbancho MÁ,
|
||
García-Casares N</span><br />
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||
<span class="medgenPMjournal">Neuroradiology</span>
|
||
2021 Sep;63(9):1395-1405.
|
||
Epub 2021 Apr 13
|
||
doi: 10.1007/s00234-021-02704-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33851253" target="_blank">33851253</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32651050">Cerebrospinal Fluid Amyloid Beta, Tau Levels, Apolipoprotein, and (1)H-MRS Brain Metabolites in Alzheimer's Disease: A Systematic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Piersson AD,
|
||
Mohamad M,
|
||
Rajab F,
|
||
Suppiah S</span><br />
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||
<span class="medgenPMjournal">Acad Radiol</span>
|
||
2021 Oct;28(10):1447-1463.
|
||
Epub 2020 Jul 7
|
||
doi: 10.1016/j.acra.2020.06.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32651050" target="_blank">32651050</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29580887">Neuroimaging correlates of narcolepsy with cataplexy: A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wada M,
|
||
Mimura M,
|
||
Noda Y,
|
||
Takasu S,
|
||
Plitman E,
|
||
Honda M,
|
||
Natsubori A,
|
||
Ogyu K,
|
||
Tarumi R,
|
||
Graff-Guerrero A,
|
||
Nakajima S</span><br />
|
||
<span class="medgenPMjournal">Neurosci Res</span>
|
||
2019 May;142:16-29.
|
||
Epub 2018 Mar 23
|
||
doi: 10.1016/j.neures.2018.03.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29580887" target="_blank">29580887</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26402632">Magnetic Resonance Spectroscopy in Alzheimer's Disease: Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang H,
|
||
Tan L,
|
||
Wang HF,
|
||
Liu Y,
|
||
Yin RH,
|
||
Wang WY,
|
||
Chang XL,
|
||
Jiang T,
|
||
Yu JT</span><br />
|
||
<span class="medgenPMjournal">J Alzheimers Dis</span>
|
||
2015;46(4):1049-70.
|
||
doi: 10.3233/JAD-143225.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26402632" target="_blank">26402632</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Reduced%20brain%20creatine%20level%20by%20MRS%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5)</a></div></div>
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