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<!--
|
||
UID=1369723
|
||
ConceptID=C4476572
|
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-->
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||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Elevated brain N-acetyl aspartate level by MRS</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1369723</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4476572</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Elevated brain N-acetyl aspartate level by magnetic resonance spectroscopy</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0025053">HP:0025053</a></td></tr>
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</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">An increase in the level of N-acetyl aspartate in the brain identified by magnetic resonance spectroscopy (MRS). [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Elevated brain N-acetyl aspartate level by MRS</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/474891" ref="tree=MeSH" title="MedGen record for Congenital Systemic Disorder">Congenital Systemic Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/105425" ref="tree=MeSH" title="MedGen record for Abnormality of the nervous system">Abnormality of the nervous system</a></span><ul><li><span class="TLline"><a href="/medgen/868417" ref="tree=MeSH" title="MedGen record for Abnormal nervous system physiology">Abnormal nervous system physiology</a></span><ul><li><span class="TLline"><a href="/medgen/751376" ref="tree=MeSH" title="MedGen record for Brain imaging abnormality">Brain imaging abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/868370" ref="tree=MeSH" title="MedGen record for Abnormal metabolic brain imaging by MRS">Abnormal metabolic brain imaging by MRS</a></span><ul><li><span class="TLline"><a href="/medgen/1370991" ref="tree=MeSH" title="MedGen record for Abnormal brain N-acetyl aspartate level by MRS">Abnormal brain N-acetyl aspartate level by MRS</a></span><ul><li><span class="matched_ds">Elevated brain N-acetyl aspartate level by MRS</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_61565"><div><strong>Spongy degeneration of central nervous system</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>61565</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0206307</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Canavan disease is a leukodystrophy characterized by neurodevelopmental delays, macrocephaly, and tone abnormalities. The phenotypic spectrum ranges from the more severe typical Canavan disease (85%-90% of individuals) to the less severe atypical Canavan disease (10%-15%). Typical Canavan disease is characterized by neurodevelopmental impairment evident by ages three to five months, followed by neurodegeneration and developmental regression. The clinical course of atypical Canavan disease is more variable, with neurodevelopmental delay usually becoming evident in the first years of life and frequently followed by developmental regression later in childhood or adolescence. All individuals with Canavan disease have reduced life expectancy, with the majority surviving to age ten years and the minority living to adulthood.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/61565">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1663069"><div><strong>Combined oxidative phosphorylation defect type 14</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1663069</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4755312</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The spectrum of FARS2 deficiency ranges from the infantile-onset phenotype, characterized by epileptic encephalopathy with lactic acidosis and poor prognosis (70% of affected individuals), to the later-onset phenotype, characterized by spastic paraplegia, less severe neurologic manifestations, and longer survival (30% of affected individuals). To date FARS2 deficiency has been reported in 37 individuals from 25 families. Infantile-onset phenotype. Seizures are difficult to control and may progress quickly at an early age to intractable seizures with frequent status epilepticus; some children have hypsarrhythmia on EEG. All have developmental delay; most are nonverbal and unable to walk. Feeding difficulties are common. More than half of affected children die in early childhood. Later-onset phenotype. All affected individuals have spastic paraplegia manifested by weakness, spasticity, and exaggerated reflexes of the lower extremities associated with walking difficulties; some have developmental delay/intellectual disability; some have brief seizures that resolve over time.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1663069">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1823968"><div><strong>Liver disease, severe congenital</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1823968</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5774195</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Severe congenital liver disease (SCOLIV) is an autosomal recessive disorder characterized by the onset of progressive hepatic dysfunction usually in the first years of life. Affected individuals show feeding difficulties with failure to thrive and features such as jaundice, hepatomegaly, and abdominal distension. Laboratory workup is consistent with hepatic insufficiency and may also show coagulation defects, anemia, or metabolic disturbances. Cirrhosis and hypernodularity are commonly observed on liver biopsy. Many patients die of liver failure in early childhood (Moreno Traspas et al., 2022).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1823968">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1663069" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Combined oxidative phosphorylation defect type 14</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1823968" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Liver disease, severe congenital</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_61565" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Spongy degeneration of central nervous system</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33840802">Association Between Anterior Cingulate Cortex Neurochemical Profile and Clinical Remission After Electroconvulsive Treatment in Major Depressive Disorder: A Longitudinal 1H Magnetic Resonance Spectroscopy Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ermis C,
|
||
Aydin B,
|
||
Kucukguclu S,
|
||
Yurt A,
|
||
Renshaw PF,
|
||
Yildiz A</span><br />
|
||
<span class="medgenPMjournal">J ECT</span>
|
||
2021 Dec 1;37(4):263-269.
|
||
doi: 10.1097/YCT.0000000000000766.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33840802" target="_blank">33840802</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27164711">Myo-inositol changes precede amyloid pathology and relate to APOE genotype in Alzheimer disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Voevodskaya O,
|
||
Sundgren PC,
|
||
Strandberg O,
|
||
Zetterberg H,
|
||
Minthon L,
|
||
Blennow K,
|
||
Wahlund LO,
|
||
Westman E,
|
||
Hansson O;
|
||
Swedish BioFINDER study group</span><br />
|
||
<span class="medgenPMjournal">Neurology</span>
|
||
2016 May 10;86(19):1754-61.
|
||
Epub 2016 Apr 15
|
||
doi: 10.1212/WNL.0000000000002672.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27164711" target="_blank">27164711</a><a href="/pmc/articles/PMC4862247" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(elevated%20brain%20n-acetyl%20aspartate%20level%20by%20mrs)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (2)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38521366">Hippocampal neurometabolic and structural changes from pre-to post-COVID-19: A case-series study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vints WAJ,
|
||
Valatkevičienė K,
|
||
Levin O,
|
||
Weerasekera A,
|
||
Jesmanas S,
|
||
Kušleikienė S,
|
||
Česnaitienė VJ,
|
||
Himmelreich U,
|
||
Verbunt JA,
|
||
Ratai EM,
|
||
Gleiznienė R,
|
||
Masiulis N</span><br />
|
||
<span class="medgenPMjournal">Magn Reson Imaging</span>
|
||
2024 Jun;109:249-255.
|
||
Epub 2024 Mar 22
|
||
doi: 10.1016/j.mri.2024.03.032.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38521366" target="_blank">38521366</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36107232">Quantitative measurement of peritumoral concentrations of glutamate, N-acetyl aspartate, and lactate on magnetic resonance spectroscopy predicts glioblastoma-related refractory epilepsy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nakamura Y,
|
||
Inoue A,
|
||
Nishikawa M,
|
||
Ohnishi T,
|
||
Yano H,
|
||
Kanemura Y,
|
||
Ohtsuka Y,
|
||
Ozaki S,
|
||
Kusakabe K,
|
||
Suehiro S,
|
||
Yamashita D,
|
||
Shigekawa S,
|
||
Watanabe H,
|
||
Kitazawa R,
|
||
Tanaka J,
|
||
Kunieda T</span><br />
|
||
<span class="medgenPMjournal">Acta Neurochir (Wien)</span>
|
||
2022 Dec;164(12):3253-3266.
|
||
Epub 2022 Sep 15
|
||
doi: 10.1007/s00701-022-05363-y.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36107232" target="_blank">36107232</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33581932">Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Scotti-Muzzi E,
|
||
Umla-Runge K,
|
||
Soeiro-de-Souza MG</span><br />
|
||
<span class="medgenPMjournal">Eur Neuropsychopharmacol</span>
|
||
2021 Jun;47:62-73.
|
||
Epub 2021 Feb 11
|
||
doi: 10.1016/j.euroneuro.2021.01.096.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33581932" target="_blank">33581932</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33179961">Glutamatergic Correlates of Bipolar Symptoms in Adolescents.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sonmez AI,
|
||
Lewis CP,
|
||
Port JD,
|
||
Cabello-Arreola A,
|
||
Blacker CJ,
|
||
Seewoo BJ,
|
||
McKean AJ,
|
||
Leffler JM,
|
||
Frye MA,
|
||
Croarkin PE</span><br />
|
||
<span class="medgenPMjournal">J Child Adolesc Psychopharmacol</span>
|
||
2020 Dec;30(10):599-605.
|
||
Epub 2020 Nov 11
|
||
doi: 10.1089/cap.2020.0082.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33179961" target="_blank">33179961</a><a href="/pmc/articles/PMC7757593" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23928196">Magnetic resonance spectroscopy in common dementias.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kantarci K</span><br />
|
||
<span class="medgenPMjournal">Neuroimaging Clin N Am</span>
|
||
2013 Aug;23(3):393-406.
|
||
Epub 2013 Feb 27
|
||
doi: 10.1016/j.nic.2012.10.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23928196" target="_blank">23928196</a><a href="/pmc/articles/PMC3748940" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Elevated%20brain%20N-acetyl%20aspartate%20level%20by%20MRS%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (66)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37406595">Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yang YS,
|
||
Smucny J,
|
||
Zhang H,
|
||
Maddock RJ</span><br />
|
||
<span class="medgenPMjournal">Neuroimage Clin</span>
|
||
2023;39:103461.
|
||
Epub 2023 Jun 27
|
||
doi: 10.1016/j.nicl.2023.103461.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37406595" target="_blank">37406595</a><a href="/pmc/articles/PMC10509531" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26402632">Magnetic Resonance Spectroscopy in Alzheimer's Disease: Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang H,
|
||
Tan L,
|
||
Wang HF,
|
||
Liu Y,
|
||
Yin RH,
|
||
Wang WY,
|
||
Chang XL,
|
||
Jiang T,
|
||
Yu JT</span><br />
|
||
<span class="medgenPMjournal">J Alzheimers Dis</span>
|
||
2015;46(4):1049-70.
|
||
doi: 10.3233/JAD-143225.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26402632" target="_blank">26402632</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23928196">Magnetic resonance spectroscopy in common dementias.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kantarci K</span><br />
|
||
<span class="medgenPMjournal">Neuroimaging Clin N Am</span>
|
||
2013 Aug;23(3):393-406.
|
||
Epub 2013 Feb 27
|
||
doi: 10.1016/j.nic.2012.10.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23928196" target="_blank">23928196</a><a href="/pmc/articles/PMC3748940" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23666436">Magnetic resonance spectroscopy to assess neuroinflammation and neuropathic pain.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chang L,
|
||
Munsaka SM,
|
||
Kraft-Terry S,
|
||
Ernst T</span><br />
|
||
<span class="medgenPMjournal">J Neuroimmune Pharmacol</span>
|
||
2013 Jun;8(3):576-93.
|
||
Epub 2013 May 12
|
||
doi: 10.1007/s11481-013-9460-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23666436" target="_blank">23666436</a><a href="/pmc/articles/PMC3698315" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23237636">Potential of MR spectroscopy for assessment of glioma grading.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bulik M,
|
||
Jancalek R,
|
||
Vanicek J,
|
||
Skoch A,
|
||
Mechl M</span><br />
|
||
<span class="medgenPMjournal">Clin Neurol Neurosurg</span>
|
||
2013 Feb;115(2):146-53.
|
||
Epub 2012 Dec 10
|
||
doi: 10.1016/j.clineuro.2012.11.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23237636" target="_blank">23237636</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Elevated%20brain%20N-acetyl%20aspartate%20level%20by%20MRS%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (68)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33581932">Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Scotti-Muzzi E,
|
||
Umla-Runge K,
|
||
Soeiro-de-Souza MG</span><br />
|
||
<span class="medgenPMjournal">Eur Neuropsychopharmacol</span>
|
||
2021 Jun;47:62-73.
|
||
Epub 2021 Feb 11
|
||
doi: 10.1016/j.euroneuro.2021.01.096.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33581932" target="_blank">33581932</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33395994">MRS suggests multi-regional inflammation and white matter axonal damage at 11 years following perinatal HIV infection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Graham AS,
|
||
Holmes MJ,
|
||
Little F,
|
||
Dobbels E,
|
||
Cotton MF,
|
||
Laughton B,
|
||
van der Kouwe A,
|
||
Meintjes EM,
|
||
Robertson FC</span><br />
|
||
<span class="medgenPMjournal">Neuroimage Clin</span>
|
||
2020;28:102505.
|
||
Epub 2020 Nov 19
|
||
doi: 10.1016/j.nicl.2020.102505.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33395994" target="_blank">33395994</a><a href="/pmc/articles/PMC7721646" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31516913">High serum neurofilament light chain normalizes after hematopoietic stem cell transplantation for MS.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Thebault S,
|
||
R Tessier D,
|
||
Lee H,
|
||
Bowman M,
|
||
Bar-Or A,
|
||
Arnold DL,
|
||
L Atkins H,
|
||
Tabard-Cossa V,
|
||
Freedman MS</span><br />
|
||
<span class="medgenPMjournal">Neurol Neuroimmunol Neuroinflamm</span>
|
||
2019 Sep;6(5):e598.
|
||
Epub 2019 Aug 8
|
||
doi: 10.1212/NXI.0000000000000598.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31516913" target="_blank">31516913</a><a href="/pmc/articles/PMC6715458" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29860500">Intralipid/Heparin Infusion Alters Brain Metabolites Assessed With 1H-MRS Spectroscopy in Young Healthy Men.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Karczewska-Kupczewska M,
|
||
Nikolajuk A,
|
||
Filarski R,
|
||
Majewski R,
|
||
Tarasów E</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2018 Jul 1;103(7):2563-2570.
|
||
doi: 10.1210/jc.2018-00107.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29860500" target="_blank">29860500</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27770643">1H-magnetic resonance spectroscopy study of glutamate-related abnormality in bipolar disorder.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kubo H,
|
||
Nakataki M,
|
||
Sumitani S,
|
||
Iga JI,
|
||
Numata S,
|
||
Kameoka N,
|
||
Watanabe SY,
|
||
Umehara H,
|
||
Kinoshita M,
|
||
Inoshita M,
|
||
Tamaru M,
|
||
Ohta M,
|
||
Nakayama-Yamauchi C,
|
||
Funakoshi Y,
|
||
Harada M,
|
||
Ohmori T</span><br />
|
||
<span class="medgenPMjournal">J Affect Disord</span>
|
||
2017 Jan 15;208:139-144.
|
||
Epub 2016 Oct 8
|
||
doi: 10.1016/j.jad.2016.08.046.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27770643" target="_blank">27770643</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Elevated%20brain%20N-acetyl%20aspartate%20level%20by%20MRS%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (25)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39278172">Pathomechanism of infantile traumatic brain injury with a biphasic clinical course and late reduced diffusion evaluated by MR spectroscopy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yasukohchi M,
|
||
Omata T,
|
||
Ochiai K,
|
||
Sano K,
|
||
Murofushi Y,
|
||
Kimura S,
|
||
Takase N,
|
||
Honda T,
|
||
Yasukawa K,
|
||
Takanashi JI</span><br />
|
||
<span class="medgenPMjournal">J Neurol Sci</span>
|
||
2024 Nov 15;466:123228.
|
||
Epub 2024 Sep 10
|
||
doi: 10.1016/j.jns.2024.123228.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39278172" target="_blank">39278172</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36107232">Quantitative measurement of peritumoral concentrations of glutamate, N-acetyl aspartate, and lactate on magnetic resonance spectroscopy predicts glioblastoma-related refractory epilepsy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nakamura Y,
|
||
Inoue A,
|
||
Nishikawa M,
|
||
Ohnishi T,
|
||
Yano H,
|
||
Kanemura Y,
|
||
Ohtsuka Y,
|
||
Ozaki S,
|
||
Kusakabe K,
|
||
Suehiro S,
|
||
Yamashita D,
|
||
Shigekawa S,
|
||
Watanabe H,
|
||
Kitazawa R,
|
||
Tanaka J,
|
||
Kunieda T</span><br />
|
||
<span class="medgenPMjournal">Acta Neurochir (Wien)</span>
|
||
2022 Dec;164(12):3253-3266.
|
||
Epub 2022 Sep 15
|
||
doi: 10.1007/s00701-022-05363-y.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36107232" target="_blank">36107232</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34638000">Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hone-Blanchet A,
|
||
Bohsali A,
|
||
Krishnamurthy LC,
|
||
Shahid S,
|
||
Lin Q,
|
||
Zhao L,
|
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Loring D,
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Goldstein F,
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John SE,
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Fleischer CC,
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Levey A,
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Lah J,
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Qiu D,
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<span class="medgenPMjournal">Neurobiol Aging</span>
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2022 Jan;109:22-30.
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Epub 2021 Sep 20
|
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doi: 10.1016/j.neurobiolaging.2021.09.016.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34638000" target="_blank">34638000</a><a href="/pmc/articles/PMC9768839" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33179961">Glutamatergic Correlates of Bipolar Symptoms in Adolescents.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sonmez AI,
|
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Lewis CP,
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Port JD,
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Cabello-Arreola A,
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Blacker CJ,
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Seewoo BJ,
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McKean AJ,
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Leffler JM,
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Frye MA,
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<span class="medgenPMjournal">J Child Adolesc Psychopharmacol</span>
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2020 Dec;30(10):599-605.
|
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Epub 2020 Nov 11
|
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doi: 10.1089/cap.2020.0082.
|
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<span class="bold">PMID: </span><a href="/pubmed/33179961" target="_blank">33179961</a><a href="/pmc/articles/PMC7757593" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15830194">Elevated lactate as an early marker of brain injury in inflicted traumatic brain injury.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Makoroff KL,
|
||
Cecil KM,
|
||
Care M,
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Ball WS Jr</span><br />
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<span class="medgenPMjournal">Pediatr Radiol</span>
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2005 Jul;35(7):668-76.
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Epub 2005 Apr 14
|
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doi: 10.1007/s00247-005-1441-7.
|
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<span class="bold">PMID: </span><a href="/pubmed/15830194" target="_blank">15830194</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Elevated%20brain%20N-acetyl%20aspartate%20level%20by%20MRS%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (28)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37406595">Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yang YS,
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Smucny J,
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Zhang H,
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Maddock RJ</span><br />
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<span class="medgenPMjournal">Neuroimage Clin</span>
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2023;39:103461.
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||
Epub 2023 Jun 27
|
||
doi: 10.1016/j.nicl.2023.103461.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37406595" target="_blank">37406595</a><a href="/pmc/articles/PMC10509531" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36107232">Quantitative measurement of peritumoral concentrations of glutamate, N-acetyl aspartate, and lactate on magnetic resonance spectroscopy predicts glioblastoma-related refractory epilepsy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nakamura Y,
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Inoue A,
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Nishikawa M,
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Ohnishi T,
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Yano H,
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Kanemura Y,
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Ohtsuka Y,
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Ozaki S,
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Kusakabe K,
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Suehiro S,
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||
Yamashita D,
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Shigekawa S,
|
||
Watanabe H,
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||
Kitazawa R,
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||
Tanaka J,
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||
Kunieda T</span><br />
|
||
<span class="medgenPMjournal">Acta Neurochir (Wien)</span>
|
||
2022 Dec;164(12):3253-3266.
|
||
Epub 2022 Sep 15
|
||
doi: 10.1007/s00701-022-05363-y.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36107232" target="_blank">36107232</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33179961">Glutamatergic Correlates of Bipolar Symptoms in Adolescents.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sonmez AI,
|
||
Lewis CP,
|
||
Port JD,
|
||
Cabello-Arreola A,
|
||
Blacker CJ,
|
||
Seewoo BJ,
|
||
McKean AJ,
|
||
Leffler JM,
|
||
Frye MA,
|
||
Croarkin PE</span><br />
|
||
<span class="medgenPMjournal">J Child Adolesc Psychopharmacol</span>
|
||
2020 Dec;30(10):599-605.
|
||
Epub 2020 Nov 11
|
||
doi: 10.1089/cap.2020.0082.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33179961" target="_blank">33179961</a><a href="/pmc/articles/PMC7757593" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26502308">Magnetic Resonance Spectroscopy for Traumatic Brain Injury.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Croall I,
|
||
Smith FE,
|
||
Blamire AM</span><br />
|
||
<span class="medgenPMjournal">Top Magn Reson Imaging</span>
|
||
2015 Oct;24(5):267-74.
|
||
doi: 10.1097/RMR.0000000000000063.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26502308" target="_blank">26502308</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26402632">Magnetic Resonance Spectroscopy in Alzheimer's Disease: Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang H,
|
||
Tan L,
|
||
Wang HF,
|
||
Liu Y,
|
||
Yin RH,
|
||
Wang WY,
|
||
Chang XL,
|
||
Jiang T,
|
||
Yu JT</span><br />
|
||
<span class="medgenPMjournal">J Alzheimers Dis</span>
|
||
2015;46(4):1049-70.
|
||
doi: 10.3233/JAD-143225.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26402632" target="_blank">26402632</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Elevated%20brain%20N-acetyl%20aspartate%20level%20by%20MRS%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (67)</a></div></div>
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|
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<div class="portlet_content ln">
|
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<div class="nl"><a target="_blank" href="/pubmed/33581932">Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Scotti-Muzzi E,
|
||
Umla-Runge K,
|
||
Soeiro-de-Souza MG</span><br />
|
||
<span class="medgenPMjournal">Eur Neuropsychopharmacol</span>
|
||
2021 Jun;47:62-73.
|
||
Epub 2021 Feb 11
|
||
doi: 10.1016/j.euroneuro.2021.01.096.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33581932" target="_blank">33581932</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26402632">Magnetic Resonance Spectroscopy in Alzheimer's Disease: Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang H,
|
||
Tan L,
|
||
Wang HF,
|
||
Liu Y,
|
||
Yin RH,
|
||
Wang WY,
|
||
Chang XL,
|
||
Jiang T,
|
||
Yu JT</span><br />
|
||
<span class="medgenPMjournal">J Alzheimers Dis</span>
|
||
2015;46(4):1049-70.
|
||
doi: 10.3233/JAD-143225.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26402632" target="_blank">26402632</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Elevated%20brain%20N-acetyl%20aspartate%20level%20by%20MRS%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2)</a></div></div>
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67d355f12f30673f7b368293">Elevated brain N-acetyl aspartate level by MRS</a>
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