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<!--
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UID=120495
|
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ConceptID=C0264112
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Vertebral wedging</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>120495</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0264112</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Anatomical Abnormality</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Wedge-shaped vertebrae; Wedged vertebrae</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Wedging of vertebra (19888007)</td></tr>
|
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<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0008422">HP:0008422</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">An abnormal shape of the vertebral bodies whereby the vertebral bodies are thick on one side and taper to a thin edge at the other. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Vertebral wedging</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867418" ref="tree=MeSH" title="MedGen record for Abnormality of the skeletal system">Abnormality of the skeletal system</a></span><ul><li><span class="TLline"><a href="/medgen/868760" ref="tree=MeSH" title="MedGen record for Abnormal skeletal morphology">Abnormal skeletal morphology</a></span><ul><li><span class="TLline"><a href="/medgen/892434" ref="tree=MeSH" title="MedGen record for Abnormal axial skeleton morphology">Abnormal axial skeleton morphology</a></span><ul><li><span class="TLline"><a href="/medgen/892426" ref="tree=MeSH" title="MedGen record for Abnormality of the vertebral column">Abnormality of the vertebral column</a></span><ul><li><span class="TLline"><a href="/medgen/371742" ref="tree=MeSH" title="MedGen record for Abnormal vertebral morphology">Abnormal vertebral morphology</a></span><ul><li><span class="TLline"><a href="/medgen/374194" ref="tree=MeSH" title="MedGen record for Abnormal form of the vertebral bodies">Abnormal form of the vertebral bodies</a></span><ul><li><span class="matched_ds">Vertebral wedging</span><ul><li><span class="TLline"><a href="/medgen/870239" ref="tree=MeSH" title="MedGen record for Anterior wedging of L1">Anterior wedging of L1</a></span></li><li><span class="TLline"><a href="/medgen/868711" ref="tree=MeSH" title="MedGen record for Anterior wedging of L2">Anterior wedging of L2</a></span></li><li><span class="TLline"><a href="/medgen/867290" ref="tree=MeSH" title="MedGen record for Anterior wedging of T11">Anterior wedging of T11</a></span></li><li><span class="TLline"><a href="/medgen/866758" ref="tree=MeSH" title="MedGen record for Anterior wedging of T12">Anterior wedging of T12</a></span></li><li><span class="TLline"><a href="/medgen/370074" ref="tree=MeSH" title="MedGen record for Posterior wedging of vertebral bodies">Posterior wedging of vertebral bodies</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_2554"><div><strong>Gorlin syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>2554</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0004779</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Nevoid basal cell carcinoma syndrome (NBCCS) is characterized by the development of multiple jaw keratocysts, frequently beginning in the second decade of life, and/or basal cell carcinomas (BCCs), usually from the third decade onward. Many individuals have a recognizable appearance with macrocephaly, frontal bossing, coarse facial features, and facial milia. Most individuals have skeletal anomalies (e.g., bifid ribs, wedge-shaped vertebrae). Ectopic calcification, particularly in the falx, is present in 90% of affected individuals by age 30 years. Cardiac and ovarian fibromas occur in approximately 2% and 20% of individuals, respectively. Approximately 5% of all children with NBCCS develop medulloblastoma (primitive neuroectodermal tumor), generally the desmoplastic subtype. The risk of developing medulloblastoma is substantially higher in individuals with an SUFU pathogenic variant (33%) than in those with a PTCH1 pathogenic variant (<2%). Peak incidence is at age one to two years. Life expectancy in NBCCS is not significantly different from average.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/2554">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_342431"><div><strong>Bruck syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>342431</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1850168</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Bruck syndrome-1 (BRKS1) is characterized by congenital contractures with pterygia, onset of fractures in infancy or early childhood, postnatal short stature, severe limb deformity, and progressive scoliosis (McPherson and Clemens, 1997). Genetic Heterogeneity of Bruck Syndrome Bruck syndrome-2 (BRKS2; 609220) is caused by homozygous mutation in the PLOD2 gene (601865) on chromosome 3q24. Van der Slot et al. (2003) stated that they were unaware of any phenotypic differences between the 2 forms of Bruck syndrome.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/342431">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_419686"><div><strong>Richieri Costa-da Silva syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>419686</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2930978</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A rare genetic myotonic syndrome characterised by childhood onset of progressive and severe myotonia (with generalised muscular hypertrophy and progressive impairment of gait) short stature, skeletal abnormalities (including pectus carinatum, short, wedge-shaped thoracolumbar vertebrae, kyphoscoliosis, genu valgum, irregular femoral epiphyses) and mild to moderate intellectual deficiency. Facial dysmorphism and joint limitation are not associated. There have been no further descriptions in the literature since 1984.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/419686">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_419332"><div><strong>Osteogenesis imperfecta type 5</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>419332</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2931093</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Osteogenesis imperfecta (OI) is a connective tissue disorder characterized by bone fragility and low bone mass. Due to considerable phenotypic variability, Sillence et al. (1979) developed a classification of OI subtypes based on clinical features and disease severity: OI type I, with blue sclerae (166200); perinatal lethal OI type II, also known as congenital OI (166210); OI type III, a progressively deforming form with normal sclerae (259420); and OI type IV, with normal sclerae (166220). Most forms of OI are autosomal dominant with mutations in one of the 2 genes that code for type I collagen alpha chains, COL1A1 (120150) and COL1A2 (120160). Glorieux et al. (2000) described a novel autosomal dominant form of OI, which they designated OI type V (OI5), in 7 patients. The disorder was similar to OI type IV but had distinctive clinical, histologic, and molecular characteristics. OI type V is characterized by calcification of the forearm interosseous membrane, radial head dislocation, a subphyseal metaphyseal radiodense line, and hyperplastic callus formation (summary by Cho et al., 2012). OI type V has a variable phenotype. For example, in patients with the more common c.-14C-T variant (614757.0001), distinctive radiographic findings (calcification of the forearm interosseous membrane, radial head dislocation, a subphyseal metaphyseal radiodense line, and hyperplastic callus formation) are often seen, whereas these findings are not seen in patients with the less common S40L variant (614757.0002).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/419332">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_462568"><div><strong>Osteogenesis imperfecta type 11</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462568</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3151218</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Osteogenesis imperfecta (OI) comprises a group of connective tissue disorders characterized by bone fragility and low bone mass. The disorder is clinically and genetically heterogeneous. OI type XI is an autosomal recessive form of OI (summary by Alanay et al., 2010).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462568">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_905084"><div><strong>Spondyloepiphyseal dysplasia, Stanescu type</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>905084</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4225273</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Spondyloepiphyseal dysplasia with accumulation of glycoprotein in chondrocytes has been designated the 'Stanescu type.' Clinical hallmarks include progressive joint contracture with premature degenerative joint disease, particularly in the knee, hip, and finger joints. Interphalangeal joints of the hands are swollen due to osseous distention of the metaphyseal ends of the phalanges. Affected individuals may be relatively tall despite the presence of a short trunk. Radiologically, there is generalized platyspondyly with mild modification of the endplates, hypoplastic pelvis, epiphyseal flattening with metaphyseal splaying of the long bones, and enlarged phalangeal epimetaphyses of the hands. In addition, the proximal femora are characteristically broad and elongated with striking coxa valga (summary by Nishimura et al., 1998).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/905084">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1620874"><div><strong>Epiphyseal dysplasia, multiple, 7</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1620874</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4540251</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1620874">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1632904"><div><strong>Short-rib thoracic dysplasia 18 with polydactyly</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1632904</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4693420</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Short-rib thoracic dysplasia (SRTD) with or without polydactyly refers to a group of autosomal recessive skeletal ciliopathies that are characterized by a constricted thoracic cage, short ribs, shortened tubular bones, and a 'trident' appearance of the acetabular roof. SRTD encompasses Ellis-van Creveld syndrome (EVC) and the disorders previously designated as Jeune syndrome or asphyxiating thoracic dystrophy (ATD), short rib-polydactyly syndrome (SRPS), and Mainzer-Saldino syndrome (MZSDS). Polydactyly is variably present, and there is phenotypic overlap in the various forms of SRTDs, which differ by visceral malformation and metaphyseal appearance. Nonskeletal involvement can include cleft lip/palate as well as anomalies of major organs such as the brain, eye, heart, kidneys, liver, pancreas, intestines, and genitalia. Some forms of SRTD are lethal in the neonatal period due to respiratory insufficiency secondary to a severely restricted thoracic cage, whereas others are compatible with life (summary by Huber and Cormier-Daire, 2012 and Schmidts et al., 2013). There is phenotypic overlap with the cranioectodermal dysplasias (Sensenbrenner syndrome; see CED1, 218330). For a discussion of genetic heterogeneity of short-rib thoracic dysplasia with or without polydactyly, see SRTD1 (208500).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1632904">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1648353"><div><strong>Osteogenesis imperfecta, type 19</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1648353</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4746956</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Osteogenesis imperfecta type XIX (OI19) is characterized by prenatal fractures and generalized osteopenia, with severe short stature in adulthood, as well as variable scoliosis and pectal deformity, and marked anterior angulation of the tibia (Lindert et al., 2016).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1648353">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_342431" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bruck syndrome 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1620874" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Epiphyseal dysplasia, multiple, 7</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_2554" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Gorlin syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462568" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Osteogenesis imperfecta type 11</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_419332" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Osteogenesis imperfecta type 5</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (9)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1648353" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Osteogenesis imperfecta, type 19</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_419686" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Richieri Costa-da Silva syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1632904" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Short-rib thoracic dysplasia 18 with polydactyly</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_905084" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Spondyloepiphyseal dysplasia, Stanescu type</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38740612">Flexible posterior vertebral tethering for the management of Scheuermann's kyphosis: correction by using growth modulation-clinical and radiographic outcomes of the first 10 patients with at least 3 years of follow-up.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Aydogan M,
|
||
Pehlivanoglu T,
|
||
Erdag Y,
|
||
Akturk UD,
|
||
Akar A</span><br />
|
||
<span class="medgenPMjournal">Eur Spine J</span>
|
||
2024 Jul;33(7):2677-2687.
|
||
Epub 2024 May 14
|
||
doi: 10.1007/s00586-024-08297-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38740612" target="_blank">38740612</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21173627">Nonfusion treatment of adolescent idiopathic scoliosis by growth modulation and remodeling.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Aronsson DD,
|
||
Stokes IA</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Orthop</span>
|
||
2011 Jan-Feb;31(1 Suppl):S99-106.
|
||
doi: 10.1097/BPO.0b013e318203b141.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21173627" target="_blank">21173627</a><a href="/pmc/articles/PMC3086537" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6782681">Scheuermann's kyphosis--long-term results of Milwaukee braces treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Montgomery SP,
|
||
Erwin WE</span><br />
|
||
<span class="medgenPMjournal">Spine (Phila Pa 1976)</span>
|
||
1981 Jan-Feb;6(1):5-8.
|
||
doi: 10.1097/00007632-198101000-00002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6782681" target="_blank">6782681</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22vertebral%20wedging%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (4)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32228067">Essential lordosis revisited.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hershkovich O,
|
||
D'Souza A,
|
||
Rushton PRP,
|
||
Onosi IS,
|
||
Yoon WW,
|
||
Grevitt MP</span><br />
|
||
<span class="medgenPMjournal">Bone Joint J</span>
|
||
2020 Apr;102-B(4):513-518.
|
||
doi: 10.1302/0301-620X.102B4.BJJ-2019-1069.R1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32228067" target="_blank">32228067</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28005181">The natural history of thoracolumbar kyphosis in achondroplasia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ahmed M,
|
||
El-Makhy M,
|
||
Grevitt M</span><br />
|
||
<span class="medgenPMjournal">Eur Spine J</span>
|
||
2019 Nov;28(11):2602-2607.
|
||
Epub 2016 Dec 22
|
||
doi: 10.1007/s00586-016-4861-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28005181" target="_blank">28005181</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24468666">Scheuermann's disease: an update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Palazzo C,
|
||
Sailhan F,
|
||
Revel M</span><br />
|
||
<span class="medgenPMjournal">Joint Bone Spine</span>
|
||
2014 May;81(3):209-14.
|
||
Epub 2014 Jan 24
|
||
doi: 10.1016/j.jbspin.2013.11.012.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24468666" target="_blank">24468666</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21705553">Scheuermann's kyphosis; current controversies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tsirikos AI,
|
||
Jain AK</span><br />
|
||
<span class="medgenPMjournal">J Bone Joint Surg Br</span>
|
||
2011 Jul;93(7):857-64.
|
||
doi: 10.1302/0301-620X.93B7.26129.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21705553" target="_blank">21705553</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3124936">Atraumatic vertebral deformities in elderly males.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Drinka PJ,
|
||
Bauwens SF,
|
||
DeSmet AA</span><br />
|
||
<span class="medgenPMjournal">Calcif Tissue Int</span>
|
||
1987 Dec;41(6):299-302.
|
||
doi: 10.1007/BF02556665.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3124936" target="_blank">3124936</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Vertebral%20wedging%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (72)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36689574">Post-Maturity Progression in Adolescent Idiopathic Scoliosis Curves of 40° to 50°.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yu SH,
|
||
Ng CM,
|
||
Cheung JP,
|
||
Shea GK</span><br />
|
||
<span class="medgenPMjournal">J Bone Joint Surg Am</span>
|
||
2023 Feb 15;105(4):277-285.
|
||
Epub 2023 Jan 23
|
||
doi: 10.2106/JBJS.22.00939.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36689574" target="_blank">36689574</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25463399">Three-dimensional vertebral wedging and pelvic asymmetries in the early stages of adolescent idiopathic scoliosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Begon M,
|
||
Scherrer SA,
|
||
Coillard C,
|
||
Rivard CH,
|
||
Allard P</span><br />
|
||
<span class="medgenPMjournal">Spine J</span>
|
||
2015 Mar 1;15(3):477-86.
|
||
Epub 2014 Oct 13
|
||
doi: 10.1016/j.spinee.2014.10.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25463399" target="_blank">25463399</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24468666">Scheuermann's disease: an update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Palazzo C,
|
||
Sailhan F,
|
||
Revel M</span><br />
|
||
<span class="medgenPMjournal">Joint Bone Spine</span>
|
||
2014 May;81(3):209-14.
|
||
Epub 2014 Jan 24
|
||
doi: 10.1016/j.jbspin.2013.11.012.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24468666" target="_blank">24468666</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23299906">Back pain during growth.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hasler CC</span><br />
|
||
<span class="medgenPMjournal">Swiss Med Wkly</span>
|
||
2013;143:w13714.
|
||
Epub 2013 Jan 8
|
||
doi: 10.4414/smw.2013.13714.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23299906" target="_blank">23299906</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21705553">Scheuermann's kyphosis; current controversies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tsirikos AI,
|
||
Jain AK</span><br />
|
||
<span class="medgenPMjournal">J Bone Joint Surg Br</span>
|
||
2011 Jul;93(7):857-64.
|
||
doi: 10.1302/0301-620X.93B7.26129.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21705553" target="_blank">21705553</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Vertebral%20wedging%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (30)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35997944">Reliability of radiographic assessment of growth modulation from anterior vertebral body tethering surgery in pediatric scoliosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Photopoulos G,
|
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Hurry J,
|
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Murphy J,
|
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Brooks J,
|
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Fitzgerald R,
|
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Louer C,
|
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Shaw K,
|
||
Smit K,
|
||
Miyanji F,
|
||
Parent S;
|
||
Pediatric Spine Study Group,
|
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El-Hawary R</span><br />
|
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<span class="medgenPMjournal">Spine Deform</span>
|
||
2023 Jan;11(1):115-121.
|
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Epub 2022 Aug 23
|
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doi: 10.1007/s43390-022-00570-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35997944" target="_blank">35997944</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21705553">Scheuermann's kyphosis; current controversies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tsirikos AI,
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Jain AK</span><br />
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<span class="medgenPMjournal">J Bone Joint Surg Br</span>
|
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2011 Jul;93(7):857-64.
|
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doi: 10.1302/0301-620X.93B7.26129.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21705553" target="_blank">21705553</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21173627">Nonfusion treatment of adolescent idiopathic scoliosis by growth modulation and remodeling.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Aronsson DD,
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Stokes IA</span><br />
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<span class="medgenPMjournal">J Pediatr Orthop</span>
|
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2011 Jan-Feb;31(1 Suppl):S99-106.
|
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doi: 10.1097/BPO.0b013e318203b141.
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<span class="bold">PMID: </span><a href="/pubmed/21173627" target="_blank">21173627</a><a href="/pmc/articles/PMC3086537" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6731008">Degree of vertebral wedging of the dorso-lumbar spine.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lauridsen KN,
|
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De Carvalho A,
|
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Andersen AH</span><br />
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<span class="medgenPMjournal">Acta Radiol Diagn (Stockh)</span>
|
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1984;25(1):29-32.
|
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doi: 10.1177/028418518402500106.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6731008" target="_blank">6731008</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/598175">Juvenile kyphosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bradford DS</span><br />
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<span class="medgenPMjournal">Clin Orthop Relat Res</span>
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1977 Oct;(128):45-55.
|
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<span class="bold">PMID: </span><a href="/pubmed/598175" target="_blank">598175</a></div>
|
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Vertebral%20wedging%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (14)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37773144">Novel dual: rod plate system for EOS improves vertebral wedging and permits spinal growth.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zheng Y,
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Zhou J,
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||
Niu C,
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Ye Q,
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Tang J,
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Wang X,
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Wang G</span><br />
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<span class="medgenPMjournal">J Orthop Surg Res</span>
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2023 Sep 29;18(1):738.
|
||
doi: 10.1186/s13018-023-04094-9.
|
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<span class="bold">PMID: </span><a href="/pubmed/37773144" target="_blank">37773144</a><a href="/pmc/articles/PMC10540359" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36689574">Post-Maturity Progression in Adolescent Idiopathic Scoliosis Curves of 40° to 50°.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yu SH,
|
||
Ng CM,
|
||
Cheung JP,
|
||
Shea GK</span><br />
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||
<span class="medgenPMjournal">J Bone Joint Surg Am</span>
|
||
2023 Feb 15;105(4):277-285.
|
||
Epub 2023 Jan 23
|
||
doi: 10.2106/JBJS.22.00939.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36689574" target="_blank">36689574</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29281728">Vertebral cross-sectional growth: A predictor of vertebral wedging in the immature skeleton.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Poorghasamians E,
|
||
Aggabao PC,
|
||
Wren TAL,
|
||
Ponrartana S,
|
||
Gilsanz V</span><br />
|
||
<span class="medgenPMjournal">PLoS One</span>
|
||
2017;12(12):e0190225.
|
||
Epub 2017 Dec 27
|
||
doi: 10.1371/journal.pone.0190225.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29281728" target="_blank">29281728</a><a href="/pmc/articles/PMC5745000" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21705553">Scheuermann's kyphosis; current controversies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tsirikos AI,
|
||
Jain AK</span><br />
|
||
<span class="medgenPMjournal">J Bone Joint Surg Br</span>
|
||
2011 Jul;93(7):857-64.
|
||
doi: 10.1302/0301-620X.93B7.26129.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21705553" target="_blank">21705553</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8567140">The incidence of vertebral body metastases.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ortiz Gómez JA</span><br />
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<span class="medgenPMjournal">Int Orthop</span>
|
||
1995;19(5):309-11.
|
||
doi: 10.1007/BF00181116.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8567140" target="_blank">8567140</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Vertebral%20wedging%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (28)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36689574">Post-Maturity Progression in Adolescent Idiopathic Scoliosis Curves of 40° to 50°.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yu SH,
|
||
Ng CM,
|
||
Cheung JP,
|
||
Shea GK</span><br />
|
||
<span class="medgenPMjournal">J Bone Joint Surg Am</span>
|
||
2023 Feb 15;105(4):277-285.
|
||
Epub 2023 Jan 23
|
||
doi: 10.2106/JBJS.22.00939.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36689574" target="_blank">36689574</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34330099">Contribution of postoperative vertebral remodeling to reversal of vertebral wedging and prevention of correction loss in patients with adolescent Scheuermann's kyphosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang S,
|
||
Xu L,
|
||
Wang M,
|
||
Qiu Y,
|
||
Zhu Z,
|
||
Wang B,
|
||
Sun X</span><br />
|
||
<span class="medgenPMjournal">J Neurosurg Spine</span>
|
||
2021 Oct 1;35(4):486-494.
|
||
Epub 2021 Jul 30
|
||
doi: 10.3171/2021.1.SPINE202086.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34330099" target="_blank">34330099</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29281728">Vertebral cross-sectional growth: A predictor of vertebral wedging in the immature skeleton.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Poorghasamians E,
|
||
Aggabao PC,
|
||
Wren TAL,
|
||
Ponrartana S,
|
||
Gilsanz V</span><br />
|
||
<span class="medgenPMjournal">PLoS One</span>
|
||
2017;12(12):e0190225.
|
||
Epub 2017 Dec 27
|
||
doi: 10.1371/journal.pone.0190225.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29281728" target="_blank">29281728</a><a href="/pmc/articles/PMC5745000" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25463399">Three-dimensional vertebral wedging and pelvic asymmetries in the early stages of adolescent idiopathic scoliosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Begon M,
|
||
Scherrer SA,
|
||
Coillard C,
|
||
Rivard CH,
|
||
Allard P</span><br />
|
||
<span class="medgenPMjournal">Spine J</span>
|
||
2015 Mar 1;15(3):477-86.
|
||
Epub 2014 Oct 13
|
||
doi: 10.1016/j.spinee.2014.10.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25463399" target="_blank">25463399</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21705553">Scheuermann's kyphosis; current controversies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tsirikos AI,
|
||
Jain AK</span><br />
|
||
<span class="medgenPMjournal">J Bone Joint Surg Br</span>
|
||
2011 Jul;93(7):857-64.
|
||
doi: 10.1302/0301-620X.93B7.26129.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21705553" target="_blank">21705553</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Vertebral%20wedging%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (42)</a></div></div>
|
||
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|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22vertebral%20wedging%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Vertebral%20wedging" target="_blank">MedlinePlus</a></li></ul></div>
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<a class="text-white" href="https://www.hhs.gov/">HHS</a>
|
||
</li>
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||
<li>
|
||
<a class="text-white" href="https://www.usa.gov/">USA.gov</a>
|
||
</li>
|
||
</ul>
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||
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||
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