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<!--
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UID=115980
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ConceptID=C0235081
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Limb tremor</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>115980</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0235081</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Sign or Symptom</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
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<td>Limb Tremor; Limb Tremors; Tremor, Limb</td></tr>
|
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<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0200085">HP:0200085</a></td></tr>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Limb tremor</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/105425" ref="tree=MeSH" title="MedGen record for Abnormality of the nervous system">Abnormality of the nervous system</a></span><ul><li><span class="TLline"><a href="/medgen/868417" ref="tree=MeSH" title="MedGen record for Abnormal nervous system physiology">Abnormal nervous system physiology</a></span><ul><li><span class="TLline"><a href="/medgen/10113" ref="tree=MeSH" title="MedGen record for Movement disorder">Movement disorder</a></span><ul><li><span class="TLline"><a href="/medgen/8514" ref="tree=MeSH" title="MedGen record for Dyskinesia">Dyskinesia</a></span><ul><li><span class="TLline"><a href="/medgen/21635" ref="tree=MeSH" title="MedGen record for Tremor">Tremor</a></span><ul><li><span class="TLline"><a href="/medgen/868201" ref="tree=MeSH" title="MedGen record for Tremor by anatomical site">Tremor by anatomical site</a></span><ul><li><span class="matched_ds">Limb tremor</span><ul><li><span class="TLline"><a href="/medgen/357212" ref="tree=MeSH" title="MedGen record for Upper limb postural tremor">Upper limb postural tremor</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_58144"><div><strong>Angelman syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>58144</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0162635</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Angelman syndrome (AS) is characterized by severe developmental delay or intellectual disability, severe speech impairment, gait ataxia and/or tremulousness of the limbs, and unique behavior with an apparent happy demeanor that includes frequent laughing, smiling, and excitability. Microcephaly and seizures are also common. Developmental delays are first noted at around age six months; however, the unique clinical features of AS do not become manifest until after age one year.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/58144">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_162893"><div><strong>Agenesis of the corpus callosum with peripheral neuropathy</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>162893</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0795950</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hereditary motor and sensory neuropathy with agenesis of the corpus callosum (HMSN/ACC), a neurodevelopmental and neurodegenerative disorder, is characterized by severe progressive sensorimotor neuropathy with resulting hypotonia, areflexia, and amyotrophy, and by variable degrees of dysgenesis of the corpus callosum. Mild-to-severe intellectual disability and "psychotic episodes" during adolescence are observed. Sensory modalities are moderately to severely affected beginning in infancy. The average age of onset of walking is 3.8 years; the average age of loss of walking is 13.8 years; the average age of death is 33 years.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/162893">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_220945"><div><strong>Deficiency of aromatic-L-amino-acid decarboxylase</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>220945</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1291564</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Individuals with aromatic L-amino acid decarboxylase (AADC) deficiency typically have complex symptoms, including motor, behavioral, cognitive, and autonomic findings. Symptom onset is in early infancy, typically within the first six months of life. The most common initial symptoms are often nonspecific, and include feeding difficulties, hypotonia, and developmental delay. More specific symptoms include oculogyric crises (which occur in the vast majority of affected individuals, typically starting in infancy), movement disorders (especially dystonia), and autonomic dysfunction (excessive sweating, temperature instability, ptosis, nasal congestion, hypoglycemic episodes). Sleep disturbance is present in a majority of affected individuals and can include insomnia, hypersomnia, or both. Mood disturbance, including irritability and anxiety, are also common. Brain MRI is typically either normal or may demonstrate nonspecific abnormalities, such as mild diffuse cerebral atrophy or delayed myelination. Seizures are an uncommon finding, occurring in fewer than 5% of affected individuals.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/220945">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_376792"><div><strong>Neuronal ceroid lipofuscinosis 5</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>376792</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1850442</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The neuronal ceroid lipofuscinoses (NCL; CLN) are a clinically and genetically heterogeneous group of neurodegenerative disorders characterized by the intracellular accumulation of autofluorescent lipopigment storage material in different patterns ultrastructurally. The lipopigment patterns observed most often in CLN5 comprise mixed combinations of 'granular,' 'curvilinear,' and 'fingerprint' profiles. The clinical course includes progressive dementia, seizures, and progressive visual failure (Mole et al., 2005). For a general phenotypic description and a discussion of genetic heterogeneity of CLN, see CLN1 (256730).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/376792">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_437111"><div><strong>Syndromic X-linked intellectual disability 94</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>437111</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2678051</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A syndromic X-linked intellectual disability characterized by moderate intellectual disability with variable occurrence of asthenic body habitus, dysmorphic features, autistic features, macrocephaly, seizures, myoclonic jerks, and hyporeflexia that has material basis in mutation in the GRIA3 gene on chromosome Xq25.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/437111">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_766874"><div><strong>Peroxisome biogenesis disorder 8B</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766874</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3553960</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The overlapping phenotypes of neonatal adrenoleukodystrophy (NALD) and infantile Refsum disease (IRD) represent the milder manifestations of the Zellweger syndrome spectrum (ZSS) of peroxisome biogenesis disorders. The clinical course of patients with the NALD and IRD presentation is variable and may include developmental delay, hypotonia, liver dysfunction, sensorineural hearing loss, retinal dystrophy, and visual impairment. Children with the NALD presentation may reach their teens, and those with the IRD presentation may reach adulthood (summary by Waterham and Ebberink, 2012). For a complete phenotypic description and a discussion of genetic heterogeneity of PBD(NALD/IRD), see 601539. Individuals with mutations in the PEX16 gene have cells of complementation group 9 (CG9, equivalent to CGD). For information on the history of PBD complementation groups, see 214100.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/766874">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_767288"><div><strong>Dystonia 24</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>767288</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3554374</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Dystonia-24 is an autosomal dominant form of focal dystonia affecting the neck, laryngeal muscles, and muscles of the upper limbs (summary by Charlesworth et al., 2012).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/767288">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_904159"><div><strong>Developmental and epileptic encephalopathy, 35</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>904159</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4225256</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Developmental and epileptic encephalopathy-35 (DEE35) is an autosomal recessive neurodegenerative disorder characterized by onset of seizures in the first months of life associated with essentially no normal development. Brain imaging shows a characteristic pattern consistent with lack of myelination of early structures, including the posterior limb of the internal capsule, brainstem tracts, and tracts to the primary visual and motor cortices. Many patients die in early childhood (summary by Kevelam et al., 2015) For a general phenotypic description and a discussion of genetic heterogeneity of DEE, see 308350.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/904159">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1803276"><div><strong>Chilton-Okur-Chung neurodevelopmental syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1803276</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5677022</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Chilton-Okur-Chung neurodevelopmental syndrome (CHOCNS) is characterized mainly by global developmental delay with variably impaired intellectual development and occasional speech delay. Most patients have behavioral abnormalities, including autism spectrum disorder, ADHD, and aggression. About half of patients have dysmorphic facial features, and about half have nonspecific brain abnormalities, including thin corpus callosum. Rare involvement of other organ systems may be present. At least 1 child with normal development at age 2.5 years has been reported (Chilton et al., 2020).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1803276">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_162893" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Agenesis of the corpus callosum with peripheral neuropathy</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_58144" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Angelman syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1803276" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Chilton-Okur-Chung neurodevelopmental syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_220945" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Deficiency of aromatic-L-amino-acid decarboxylase</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_904159" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Developmental and epileptic encephalopathy, 35</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (9)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_767288" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dystonia 24</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_376792" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neuronal ceroid lipofuscinosis 5</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_766874" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Peroxisome biogenesis disorder 8B</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_437111" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Syndromic X-linked intellectual disability 94</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/31575730">Treatment of essential tremor: current status.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sharma S,
|
||
Pandey S</span><br />
|
||
<span class="medgenPMjournal">Postgrad Med J</span>
|
||
2020 Feb;96(1132):84-93.
|
||
Epub 2019 Oct 1
|
||
doi: 10.1136/postgradmedj-2019-136647.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31575730" target="_blank">31575730</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29125566">Botulinum Toxin in Management of Limb Tremor.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zakin E,
|
||
Simpson D</span><br />
|
||
<span class="medgenPMjournal">Toxins (Basel)</span>
|
||
2017 Nov 10;9(11)
|
||
doi: 10.3390/toxins9110365.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29125566" target="_blank">29125566</a><a href="/pmc/articles/PMC5705980" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24142589">The treatment of tremor.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schneider SA,
|
||
Deuschl G</span><br />
|
||
<span class="medgenPMjournal">Neurotherapeutics</span>
|
||
2014 Jan;11(1):128-38.
|
||
doi: 10.1007/s13311-013-0230-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24142589" target="_blank">24142589</a><a href="/pmc/articles/PMC3899476" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22limb%20tremor%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (16)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39900299">Botulinum toxin for essential tremor.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gulati K,
|
||
Pandey S</span><br />
|
||
<span class="medgenPMjournal">Toxicon</span>
|
||
2025 Mar;256:108273.
|
||
Epub 2025 Feb 1
|
||
doi: 10.1016/j.toxicon.2025.108273.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39900299" target="_blank">39900299</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/39330850">Use of Botulinum Toxin in Upper-Limb Tremor: Systematic Review and Perspectives.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Motavasseli D,
|
||
Delorme C,
|
||
Bayle N,
|
||
Gracies JM,
|
||
Roze E,
|
||
Baude M</span><br />
|
||
<span class="medgenPMjournal">Toxins (Basel)</span>
|
||
2024 Sep 13;16(9)
|
||
doi: 10.3390/toxins16090392.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39330850" target="_blank">39330850</a><a href="/pmc/articles/PMC11436131" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38594807">Comparing Essential Tremor with and without Soft Dystonic Signs and Tremor Combined with Dystonia: The TITAN Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Erro R,
|
||
Lazzeri G,
|
||
Terranova C,
|
||
Paparella G,
|
||
Gigante AF,
|
||
De Micco R,
|
||
Magistrelli L,
|
||
Di Biasio F,
|
||
Valentino F,
|
||
Moschella V,
|
||
Pilotto A,
|
||
Esposito M,
|
||
Olivola E,
|
||
Malaguti MC,
|
||
Ceravolo R,
|
||
Dallocchio C,
|
||
Spagnolo F,
|
||
Nicoletti A,
|
||
De Rosa A,
|
||
Di Giacopo R,
|
||
Sorrentino C,
|
||
Padovani A,
|
||
Altavista MC,
|
||
Pacchetti C,
|
||
Marchese R,
|
||
Contaldi E,
|
||
Tessitore A,
|
||
Misceo S,
|
||
Bologna M,
|
||
Rizzo V,
|
||
Franco G,
|
||
Barone P;
|
||
TITAN study group</span><br />
|
||
<span class="medgenPMjournal">Mov Disord Clin Pract</span>
|
||
2024 Jun;11(6):645-654.
|
||
Epub 2024 Apr 9
|
||
doi: 10.1002/mdc3.14026.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38594807" target="_blank">38594807</a><a href="/pmc/articles/PMC11145151" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35468498">Speech-induced action myoclonus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Simpson HD,
|
||
Duffy JR,
|
||
Stierwalt JAG,
|
||
Ahlskog JE,
|
||
Hassan A</span><br />
|
||
<span class="medgenPMjournal">Parkinsonism Relat Disord</span>
|
||
2022 May;98:41-46.
|
||
Epub 2022 Apr 14
|
||
doi: 10.1016/j.parkreldis.2022.04.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35468498" target="_blank">35468498</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31422549">Tremor Distribution and the Variable Clinical Presentation of Essential Tremor.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bologna M,
|
||
Berardelli I,
|
||
Paparella G,
|
||
Ferrazzano G,
|
||
Angelini L,
|
||
Giustini P,
|
||
Alunni-Fegatelli D,
|
||
Berardelli A</span><br />
|
||
<span class="medgenPMjournal">Cerebellum</span>
|
||
2019 Oct;18(5):866-872.
|
||
doi: 10.1007/s12311-019-01070-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31422549" target="_blank">31422549</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Limb%20tremor%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (83)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/40014835">Clinical Reasoning: Juvenile-Onset Dopa-Responsive Dystonia-Until It Isn't.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chinchihualpa Paredes N,
|
||
Pecoraro PM,
|
||
Zaidi SA,
|
||
Duque KR,
|
||
Mahajan A,
|
||
Mohammad ME,
|
||
Duker AP,
|
||
Kauffman MA,
|
||
Espay AJ,
|
||
Marsili L</span><br />
|
||
<span class="medgenPMjournal">Neurology</span>
|
||
2025 Mar 25;104(6):e213436.
|
||
Epub 2025 Feb 27
|
||
doi: 10.1212/WNL.0000000000213436.
|
||
<span class="bold">PMID: </span><a href="/pubmed/40014835" target="_blank">40014835</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38218890">Upper limb intention tremor assessment: opportunities and challenges in wearable technology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Paredes-Acuna N,
|
||
Utpadel-Fischler D,
|
||
Ding K,
|
||
Thakor NV,
|
||
Cheng G</span><br />
|
||
<span class="medgenPMjournal">J Neuroeng Rehabil</span>
|
||
2024 Jan 13;21(1):8.
|
||
doi: 10.1186/s12984-023-01302-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38218890" target="_blank">38218890</a><a href="/pmc/articles/PMC10787996" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35468498">Speech-induced action myoclonus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Simpson HD,
|
||
Duffy JR,
|
||
Stierwalt JAG,
|
||
Ahlskog JE,
|
||
Hassan A</span><br />
|
||
<span class="medgenPMjournal">Parkinsonism Relat Disord</span>
|
||
2022 May;98:41-46.
|
||
Epub 2022 Apr 14
|
||
doi: 10.1016/j.parkreldis.2022.04.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35468498" target="_blank">35468498</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33815935">The Progression of Essential Tremors: Illustrative Videos.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">McGurn M,
|
||
Delgado N,
|
||
Hernandez N,
|
||
Louis ED</span><br />
|
||
<span class="medgenPMjournal">Tremor Other Hyperkinet Mov (N Y)</span>
|
||
2021 Mar 24;11:11.
|
||
doi: 10.5334/tohm.608.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33815935" target="_blank">33815935</a><a href="/pmc/articles/PMC7996433" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22509875">Upper limb tremor.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kimber TE,
|
||
Thompson PD</span><br />
|
||
<span class="medgenPMjournal">Med J Aust</span>
|
||
2012 Apr 16;196(7):447-51.
|
||
doi: 10.5694/mja11.11565.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22509875" target="_blank">22509875</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Limb%20tremor%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (89)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/40014835">Clinical Reasoning: Juvenile-Onset Dopa-Responsive Dystonia-Until It Isn't.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chinchihualpa Paredes N,
|
||
Pecoraro PM,
|
||
Zaidi SA,
|
||
Duque KR,
|
||
Mahajan A,
|
||
Mohammad ME,
|
||
Duker AP,
|
||
Kauffman MA,
|
||
Espay AJ,
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Epub 2024 Apr 9
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<span class="bold">PMID: </span><a href="/pubmed/38594807" target="_blank">38594807</a><a href="/pmc/articles/PMC11145151" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/32910593">A Detailed Clinical Course Leading to Hypoxic Ischemic Encephalopathy After Anterior Cervical Spine Surgery: A Case Report.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Matsumoto T,
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Yamashita T,
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Okuda S,
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Maeno T,
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<div class="nl"><a target="_blank" href="/pubmed/31201091">The clinical significance of lower limb tremors.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/28586370">Long-term tremor therapy for Parkinson and essential tremor with sensor-guided botulinum toxin type A injections.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/23243072">Temporal discrimination in patients with dystonia and tremor and patients with essential tremor.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Tinazzi M,
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Fasano A,
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Di Matteo A,
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Conte A,
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Bove F,
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Bovi T,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Limb%20tremor%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (33)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/39474246">Tremor Following Guillain Barré Syndrome.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Baizabal-Carvallo JF,
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Cortés CM,
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Alonso-Juarez M,
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|
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|
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<div class="nl"><a target="_blank" href="/pubmed/38594807">Comparing Essential Tremor with and without Soft Dystonic Signs and Tremor Combined with Dystonia: The TITAN Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Erro R,
|
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Lazzeri G,
|
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Terranova C,
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||
Paparella G,
|
||
Gigante AF,
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De Micco R,
|
||
Magistrelli L,
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Di Biasio F,
|
||
Valentino F,
|
||
Moschella V,
|
||
Pilotto A,
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Esposito M,
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Olivola E,
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Malaguti MC,
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Ceravolo R,
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Dallocchio C,
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Spagnolo F,
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Nicoletti A,
|
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De Rosa A,
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||
Di Giacopo R,
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||
Sorrentino C,
|
||
Padovani A,
|
||
Altavista MC,
|
||
Pacchetti C,
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||
Marchese R,
|
||
Contaldi E,
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||
Tessitore A,
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Misceo S,
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||
Bologna M,
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||
Rizzo V,
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Franco G,
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Barone P;
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TITAN study group</span><br />
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<span class="medgenPMjournal">Mov Disord Clin Pract</span>
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||
2024 Jun;11(6):645-654.
|
||
Epub 2024 Apr 9
|
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doi: 10.1002/mdc3.14026.
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<span class="bold">PMID: </span><a href="/pubmed/38594807" target="_blank">38594807</a><a href="/pmc/articles/PMC11145151" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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|
||
<div class="nl"><a target="_blank" href="/pubmed/37314215">Imbalance and lower limb tremor in chronic inflammatory demyelinating polyradiculoneuropathy.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Silsby M,
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Yiannikas C,
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Fois AF,
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Ng K,
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Kiernan MC,
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Fung VSC,
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<span class="bold">PMID: </span><a href="/pubmed/37314215" target="_blank">37314215</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/36669350">Limb positioning and magnitude of postural tremor ratings: A study of 100 essential tremor cases.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Powell A,
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Berry DS,
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<span class="medgenPMjournal">J Neurol Sci</span>
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Epub 2023 Jan 13
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||
<span class="bold">PMID: </span><a href="/pubmed/36669350" target="_blank">36669350</a><a href="/pmc/articles/PMC9900629" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32910593">A Detailed Clinical Course Leading to Hypoxic Ischemic Encephalopathy After Anterior Cervical Spine Surgery: A Case Report.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Matsumoto T,
|
||
Yamashita T,
|
||
Okuda S,
|
||
Maeno T,
|
||
Nagamoto Y,
|
||
Iwasaki M</span><br />
|
||
<span class="medgenPMjournal">JBJS Case Connect</span>
|
||
2020 Jul-Sep;10(3):e20.00236.
|
||
doi: 10.2106/JBJS.CC.20.00236.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32910593" target="_blank">32910593</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Limb%20tremor%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (80)</a></div></div>
|
||
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|
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|
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|
||
<div class="nl"><a target="_blank" href="/pubmed/39330850">Use of Botulinum Toxin in Upper-Limb Tremor: Systematic Review and Perspectives.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Motavasseli D,
|
||
Delorme C,
|
||
Bayle N,
|
||
Gracies JM,
|
||
Roze E,
|
||
Baude M</span><br />
|
||
<span class="medgenPMjournal">Toxins (Basel)</span>
|
||
2024 Sep 13;16(9)
|
||
doi: 10.3390/toxins16090392.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39330850" target="_blank">39330850</a><a href="/pmc/articles/PMC11436131" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Limb%20tremor%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22limb%20tremor%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Limb%20tremor%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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