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<meta name="keywords" content="C0553580, es, ewing sarcoma, ewing tumor, ewing tumour, ewing's family localised tumour, ewing's family localized tumor, ewing's sarcoma, ewing's sarcoma/peripheral primitive neuroectodermal tumour, ewing's tumor, ewing's tumour, ewings sarcoma, ewings sarcoma-primitive neuroectodermal tumor, ewings sarcoma-primitive neuroectodermal tumour, ewings tumor, ewsr1, localised ewing sarcoma, localised ewing's sarcoma, localised ewing's sarcoma/peripheral primitive neuroectodermal tumour, localised ewing's tumour, localised peripheral primitive neuroectodermal tumour, localized ewing sarcoma, localized ewing's sarcoma, localized ewing's sarcoma/peripheral primitive neuroectodermal tumor, localized ewing's tumor, localized peripheral primitive neuroectodermal tumor, neoplastic process, neuroepithelioma, neuroepithelioma, peripheral, osseous ewing sarcoma, peripheral primitive neuroectodermal tumour, pnet of thoracopulmonary region, sarcoma, ewing, sarcoma, ewing's, sarcoma, ewings, skeletal ewing sarcoma, tumor, ewing, tumor, ewing's, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Ewing sarcoma is a cancerous tumor that occurs in bones or soft tissues, such as cartilage or nerves. There are several types of Ewing sarcoma, including Ewing sarcoma of bone, extraosseous Ewing sarcoma, peripheral primitive neuroectodermal tumor (pPNET), and Askin tumor. These tumors are considered to be related because they have similar genetic causes. These types of Ewing sarcoma can be distinguished from one another by the tissue in which the tumor develops. Approximately 87 percent of Ewing sarcomas are Ewing sarcoma of bone, which is a bone tumor that usually occurs in the thigh bones (femurs), pelvis, ribs, or shoulder blades. Extraosseous (or extraskeletal) Ewing sarcoma describes tumors in the soft tissues around bones, such as cartilage. pPNETs occur in nerve tissue and can be found in many parts of the body. A type of pPNET found in the chest is called Askin tumor.\n\nEwing sarcomas most often occur in children and young adults. Affected individuals usually feel stiffness, pain, swelling, or tenderness of the bone or surrounding tissue. Sometimes, there is a lump near the surface of the skin that feels warm and soft to the touch. Often, children have a fever that does not go away. Ewing sarcoma of bone can cause weakening of the involved bone, and affected individuals may have a broken bone with no obvious cause.\n\nIt is common for Ewing sarcoma to spread to other parts of the body (metastasize), usually to the lungs, to other bones, or to the bone marrow." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
|
||
UID=107816
|
||
ConceptID=C0553580
|
||
-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Ewing sarcoma<span class="h1sub">(ES)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>107816</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0553580</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>ES; Ewing tumor; Ewing's sarcoma; Ewing's tumor</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Ewing's sarcoma (76909002); Ewing's tumor (76909002); Ewing sarcoma (76909002)</td></tr>
|
||
<tr><td>Modes of inheritance:</td>
|
||
<td>
|
||
<div class="divPopper rprt" id="moi_988794"><div><strong>Not genetically inherited</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>988794</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms that cannot be identified in NLM's Unified Medical Language system (UMLS) Click for more information.">CN307044</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Source: Orphanet</div>
|
||
<div class="spaceAbove">clinical entity without genetic inheritance.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/988794">This record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_988794" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Not genetically inherited</a><span> (Orphanet)</span></div></td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="EWSR1 - ID: 2130 - NCBI Gene" href="/gene/2130" class="medgenPMinfo">EWSR1</a> (22q12.2)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0012254">HP:0012254</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0012817" target="_blank">MONDO:0012817</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/612219" target="_blank">612219</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=319">ORPHA319</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
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<div class="portlet mgSection" id="ID_100">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Ewing sarcoma is a cancerous tumor that occurs in bones or soft tissues, such as cartilage or nerves. There are several types of Ewing sarcoma, including Ewing sarcoma of bone, extraosseous Ewing sarcoma, peripheral primitive neuroectodermal tumor (pPNET), and Askin tumor. These tumors are considered to be related because they have similar genetic causes. These types of Ewing sarcoma can be distinguished from one another by the tissue in which the tumor develops. Approximately 87 percent of Ewing sarcomas are Ewing sarcoma of bone, which is a bone tumor that usually occurs in the thigh bones (femurs), pelvis, ribs, or shoulder blades. Extraosseous (or extraskeletal) Ewing sarcoma describes tumors in the soft tissues around bones, such as cartilage. pPNETs occur in nerve tissue and can be found in many parts of the body. A type of pPNET found in the chest is called Askin tumor.<br /><br />Ewing sarcomas most often occur in children and young adults. Affected individuals usually feel stiffness, pain, swelling, or tenderness of the bone or surrounding tissue. Sometimes, there is a lump near the surface of the skin that feels warm and soft to the touch. Often, children have a fever that does not go away. Ewing sarcoma of bone can cause weakening of the involved bone, and affected individuals may have a broken bone with no obvious cause.<br /><br />It is common for Ewing sarcoma to spread to other parts of the body (metastasize), usually to the lungs, to other bones, or to the bone marrow. [from <a title="MedlinePlus Genetics" href="https://medlineplus.gov/genetics/" class="defSource" target="_blank">MedlinePlus Genetics</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_107816"><div><strong>Ewing sarcoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>107816</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0553580</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Ewing sarcoma is a cancerous tumor that occurs in bones or soft tissues, such as cartilage or nerves. There are several types of Ewing sarcoma, including Ewing sarcoma of bone, extraosseous Ewing sarcoma, peripheral primitive neuroectodermal tumor (pPNET), and Askin tumor. These tumors are considered to be related because they have similar genetic causes. These types of Ewing sarcoma can be distinguished from one another by the tissue in which the tumor develops. Approximately 87 percent of Ewing sarcomas are Ewing sarcoma of bone, which is a bone tumor that usually occurs in the thigh bones (femurs), pelvis, ribs, or shoulder blades. Extraosseous (or extraskeletal) Ewing sarcoma describes tumors in the soft tissues around bones, such as cartilage. pPNETs occur in nerve tissue and can be found in many parts of the body. A type of pPNET found in the chest is called Askin tumor.\n\nEwing sarcomas most often occur in children and young adults. Affected individuals usually feel stiffness, pain, swelling, or tenderness of the bone or surrounding tissue. Sometimes, there is a lump near the surface of the skin that feels warm and soft to the touch. Often, children have a fever that does not go away. Ewing sarcoma of bone can cause weakening of the involved bone, and affected individuals may have a broken bone with no obvious cause.\n\nIt is common for Ewing sarcoma to spread to other parts of the body (metastasize), usually to the lungs, to other bones, or to the bone marrow.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/107816">Feature record</a> | <a href="/medgen?term=%22Ewing%20sarcoma%22%5BClinical%20Features%5D%20OR%20107816%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite"><ul><li><span class="TLline">Neoplasm</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_107816" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ewing sarcoma</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li><li><a href="#tabORDO">Orphanet</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=483352" target="_blank" href="/omim/612219">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/483352" ref="tree=GTR&ncbi_uid=483352&link_uid=483352" title="View MedGen record for 'Peripheral neuroepithelioma'">Peripheral neuroepithelioma</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=209112" target="_blank" href="/omim/612219">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/209112" ref="tree=GTR&ncbi_uid=209112&link_uid=209112" title="View MedGen record for 'Askin tumor'">Askin tumor</a></span></li><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0553580[DISCUI]&test_type=Clinical" ref="ncbi_uid=107816">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=107816" target="_blank" href="/omim/612219">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=107816" ref="ncbi_uid=107816">V</a></span></span><span class="TLline">Ewing sarcoma</span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/272508" ref="tree=MeSH" title="MedGen record for Connective and Soft Tissue Disorder">Connective and Soft Tissue Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/1098" ref="tree=MeSH" title="MedGen record for Connective tissue disorder">Connective tissue disorder</a></span><ul><li><span class="TLline"><a href="/medgen/2701" ref="tree=MeSH" title="MedGen record for Bone Neoplasm">Bone Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/79002" ref="tree=MeSH" title="MedGen record for Bone cancer">Bone cancer</a></span><ul><li><span class="TLline"><a href="/medgen/352831" ref="tree=MeSH" title="MedGen record for Bone sarcoma">Bone sarcoma</a></span><ul><li><span class="matched_ds">Ewing sarcoma</span><ul><li><span class="TLline"><a href="/medgen/785386" ref="tree=MeSH" title="MedGen record for Atypical Ewing Sarcoma">Atypical Ewing Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/108438" ref="tree=MeSH" title="MedGen record for Ewing sarcoma of bone">Ewing sarcoma of bone</a></span><ul><li><span class="TLline"><a href="/medgen/233615" ref="tree=MeSH" title="MedGen record for Localized Bone Ewing Sarcoma">Localized Bone Ewing Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/233698" ref="tree=MeSH" title="MedGen record for Metastatic Bone Ewing Sarcoma">Metastatic Bone Ewing Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/233908" ref="tree=MeSH" title="MedGen record for Recurrent Bone Ewing Sarcoma">Recurrent Bone Ewing Sarcoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/76053" ref="tree=MeSH" title="MedGen record for Extraskeletal Ewing sarcoma">Extraskeletal Ewing sarcoma</a></span><ul><li><span class="TLline"><a href="/medgen/1702234" ref="tree=MeSH" title="MedGen record for Kidney Ewing Sarcoma">Kidney Ewing Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/163505" ref="tree=MeSH" title="MedGen record for Localized Extraskeletal Ewing Sarcoma">Localized Extraskeletal Ewing Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/163504" ref="tree=MeSH" title="MedGen record for Metastatic Extraskeletal Ewing Sarcoma">Metastatic Extraskeletal Ewing Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/208944" ref="tree=MeSH" title="MedGen record for Recurrent Extraskeletal Ewing Sarcoma">Recurrent Extraskeletal Ewing Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/1762969" ref="tree=MeSH" title="MedGen record for Skin Ewing Sarcoma">Skin Ewing Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/1793842" ref="tree=MeSH" title="MedGen record for Vulvar Ewing Sarcoma">Vulvar Ewing Sarcoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/167841" ref="tree=MeSH" title="MedGen record for Localized Ewing Sarcoma">Localized Ewing Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/75839" ref="tree=MeSH" title="MedGen record for Metastatic Ewing Sarcoma">Metastatic Ewing Sarcoma</a></span><ul><li><span class="TLline"><a href="/medgen/1717811" ref="tree=MeSH" title="MedGen record for Locally Advanced Ewing Sarcoma">Locally Advanced Ewing Sarcoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/78850" ref="tree=MeSH" title="MedGen record for Recurrent Ewing Sarcoma">Recurrent Ewing Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/1631504" ref="tree=MeSH" title="MedGen record for Refractory Ewing Sarcoma">Refractory Ewing Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/1387874" ref="tree=MeSH" title="MedGen record for Unresectable Ewing Sarcoma">Unresectable Ewing Sarcoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div><div id="tabORDO">Follow <a target="_blank" href="http://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&data_id=156&PatId=3759&search=Disease_Classif_Simple&new=1" class="ital bold">this link</a> to review classifications for <span class="ital">Ewing sarcoma</span> in Orphanet.</div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_20552"><div><strong>Retinoblastoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>20552</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0035335</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is associated with susceptibility for retinoblastoma as well as non-ocular tumors.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/20552">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_107816"><div><strong>Ewing sarcoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>107816</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0553580</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Ewing sarcoma is a cancerous tumor that occurs in bones or soft tissues, such as cartilage or nerves. There are several types of Ewing sarcoma, including Ewing sarcoma of bone, extraosseous Ewing sarcoma, peripheral primitive neuroectodermal tumor (pPNET), and Askin tumor. These tumors are considered to be related because they have similar genetic causes. These types of Ewing sarcoma can be distinguished from one another by the tissue in which the tumor develops. Approximately 87 percent of Ewing sarcomas are Ewing sarcoma of bone, which is a bone tumor that usually occurs in the thigh bones (femurs), pelvis, ribs, or shoulder blades. Extraosseous (or extraskeletal) Ewing sarcoma describes tumors in the soft tissues around bones, such as cartilage. pPNETs occur in nerve tissue and can be found in many parts of the body. A type of pPNET found in the chest is called Askin tumor.\n\nEwing sarcomas most often occur in children and young adults. Affected individuals usually feel stiffness, pain, swelling, or tenderness of the bone or surrounding tissue. Sometimes, there is a lump near the surface of the skin that feels warm and soft to the touch. Often, children have a fever that does not go away. Ewing sarcoma of bone can cause weakening of the involved bone, and affected individuals may have a broken bone with no obvious cause.\n\nIt is common for Ewing sarcoma to spread to other parts of the body (metastasize), usually to the lungs, to other bones, or to the bone marrow.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/107816">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_107816" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ewing sarcoma</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_20552" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Retinoblastoma</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37037906">Ewing sarcoma treatment: a gene therapy approach.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tsibulnikov S,
|
||
Fayzullina D,
|
||
Karlina I,
|
||
Schroeder BA,
|
||
Karpova O,
|
||
Timashev P,
|
||
Ulasov I</span><br />
|
||
<span class="medgenPMjournal">Cancer Gene Ther</span>
|
||
2023 Aug;30(8):1066-1071.
|
||
Epub 2023 Apr 10
|
||
doi: 10.1038/s41417-023-00615-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37037906" target="_blank">37037906</a><a href="/pmc/articles/PMC10088695" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30215968">Bone Cancer: Diagnosis and Treatment Principles.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ferguson JL,
|
||
Turner SP</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2018 Aug 15;98(4):205-213.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30215968" target="_blank">30215968</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21944018">Ewing sarcoma treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jürgens H,
|
||
Dirksen U</span><br />
|
||
<span class="medgenPMjournal">Eur J Cancer</span>
|
||
2011 Sep;47 Suppl 3:S366-7.
|
||
doi: 10.1016/S0959-8049(11)70206-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21944018" target="_blank">21944018</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22ewing%20sarcoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (224)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/sarcoma.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024</a></h3>
|
||
<h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/bone.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bone Cancer, 2024</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36453038">The management of sacral tumours.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rose PS</span><br />
|
||
<span class="medgenPMjournal">Bone Joint J</span>
|
||
2022 Dec;104-B(12):1284-1291.
|
||
doi: 10.1302/0301-620X.104B12.BJJ-2022-0734.R1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36453038" target="_blank">36453038</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33818887">Ewing sarcoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Eaton BR,
|
||
Claude L,
|
||
Indelicato DJ,
|
||
Vatner R,
|
||
Yeh B,
|
||
Schwarz R,
|
||
Laack N</span><br />
|
||
<span class="medgenPMjournal">Pediatr Blood Cancer</span>
|
||
2021 May;68 Suppl 2:e28355.
|
||
doi: 10.1002/pbc.28355.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33818887" target="_blank">33818887</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31995669">EWSR1 fusions: Ewing sarcoma and beyond.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jo VY</span><br />
|
||
<span class="medgenPMjournal">Cancer Cytopathol</span>
|
||
2020 Apr;128(4):229-231.
|
||
Epub 2020 Jan 29
|
||
doi: 10.1002/cncy.22239.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31995669" target="_blank">31995669</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29977059">Ewing sarcoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Grünewald TGP,
|
||
Cidre-Aranaz F,
|
||
Surdez D,
|
||
Tomazou EM,
|
||
de Álava E,
|
||
Kovar H,
|
||
Sorensen PH,
|
||
Delattre O,
|
||
Dirksen U</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Dis Primers</span>
|
||
2018 Jul 5;4(1):5.
|
||
doi: 10.1038/s41572-018-0003-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29977059" target="_blank">29977059</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/819115">Ewing's sarcoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nesbit ME</span><br />
|
||
<span class="medgenPMjournal">CA Cancer J Clin</span>
|
||
1976 May-Jun;26(3):174-80.
|
||
doi: 10.3322/canjclin.26.3.174.
|
||
<span class="bold">PMID: </span><a href="/pubmed/819115" target="_blank">819115</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ewing%20sarcoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2475)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35490205">Osteosarcoma/Ewing Sarcoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Self C,
|
||
MacQuarrie KL,
|
||
Cost CR</span><br />
|
||
<span class="medgenPMjournal">Pediatr Rev</span>
|
||
2022 May 1;43(5):256-265.
|
||
doi: 10.1542/pir.2021-005065.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35490205" target="_blank">35490205</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31802230">Ewing sarcoma and Ewing-like tumors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sbaraglia M,
|
||
Righi A,
|
||
Gambarotti M,
|
||
Dei Tos AP</span><br />
|
||
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<div class="portlet_content ln"><span class="medgenPMauthor">Choi EY,
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<div class="nl"><a target="_blank" href="/pubmed/21944018">Ewing sarcoma treatment.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/32078813">Cabozantinib in patients with advanced Ewing sarcoma or osteosarcoma (CABONE): a multicentre, single-arm, phase 2 trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Italiano A,
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Mir O,
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Mathoulin-Pelissier S,
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Penel N,
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Piperno-Neumann S,
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Bompas E,
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Chevreau C,
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Duffaud F,
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Entz-Werlé N,
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Saada E,
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Ray-Coquard I,
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Lervat C,
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Gaspar N,
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Marec-Berard P,
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Pacquement H,
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Wright J,
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Toulmonde M,
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Bessede A,
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Crombe A,
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<span class="bold">PMID: </span><a href="/pubmed/32078813" target="_blank">32078813</a><a href="/pmc/articles/PMC8763616" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/31892371">Ewing's Sarcoma of Hypopharynx.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Sánchez-Legaza E,
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<div class="nl"><a target="_blank" href="/pubmed/819115">Ewing's sarcoma.</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ewing%20sarcoma%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2559)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/38280658">Updates on WHO classification for small round cell tumors: Ewing sarcoma vs. everything else.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Weil R,
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<div class="nl"><a target="_blank" href="/pubmed/31802230">Ewing sarcoma and Ewing-like tumors.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Sbaraglia M,
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Righi A,
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Gambarotti M,
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Epub 2019 Dec 4
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doi: 10.1007/s00428-019-02720-8.
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<span class="bold">PMID: </span><a href="/pubmed/31802230" target="_blank">31802230</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Varma N,
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<div class="nl"><a target="_blank" href="/pubmed/18376284">Management of tumors of the chest wall in childhood: a review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">van den Berg H,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ewing%20sarcoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1545)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">
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||
<div class="nl"><a target="_blank" href="/pubmed/37392420">Ewing's sarcoma of the head and neck: A systematic review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Spiguel MH,
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Schuch LF,
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Kovalski LN,
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Ribeiro JT,
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Só BB,
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Silveira FM,
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Vargas PA,
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Martins MAT,
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Zanella VG,
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Aleixo PB,
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Wagner VP,
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Martins MD</span><br />
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<span class="medgenPMjournal">Oral Dis</span>
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<span class="bold">PMID: </span><a href="/pubmed/37392420" target="_blank">37392420</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34255595">Ewing Sarcoma of the Craniofacial Bones: A Qualitative Systematic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rehman R,
|
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Osto M,
|
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Parry N,
|
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Awada N,
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Agemy J,
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Arianpour K,
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Folbe AJ</span><br />
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<span class="medgenPMjournal">Otolaryngol Head Neck Surg</span>
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2022 Apr;166(4):608-614.
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Epub 2021 Jul 13
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doi: 10.1177/01945998211022228.
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<span class="bold">PMID: </span><a href="/pubmed/34255595" target="_blank">34255595</a></div>
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||
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||
<div class="nl"><a target="_blank" href="/pubmed/28117008">A Review of Ewing Sarcoma Treatment: Is it Still a Subject of Debate?</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Kridis WB,
|
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Toumi N,
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Chaari H,
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Khanfir A,
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Ayadi K,
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Keskes H,
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Boudawara T,
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Daoud J,
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||
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||
<div class="nl"><a target="_blank" href="/pubmed/27306060">Ewing sarcoma and the new emerging Ewing-like sarcomas: (CIC and BCOR-rearranged-sarcomas). A systematic review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Machado I,
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Navarro S,
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Llombart-Bosch A</span><br />
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<span class="medgenPMjournal">Histol Histopathol</span>
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2016 Nov;31(11):1169-81.
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<span class="bold">PMID: </span><a href="/pubmed/27306060" target="_blank">27306060</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12633526">A systematic review and evaluation of the use of tumour markers in paediatric oncology: Ewing's sarcoma and neuroblastoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Riley RD,
|
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Burchill SA,
|
||
Abrams KR,
|
||
Heney D,
|
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Lambert PC,
|
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Jones DR,
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Sutton AJ,
|
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Young B,
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<span class="medgenPMjournal">Health Technol Assess</span>
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<span class="bold">PMID: </span><a href="/pubmed/12633526" target="_blank">12633526</a></div>
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||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ewing%20sarcoma%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (55)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
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|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
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</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
|
||
<div class="rightCol mgCol">
|
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<div class="portlet mgSection" id="ID_113">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul id="my-toc"></ul></div>
|
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</div>
|
||
|
||
<div class="portlet mgSection" id="ID_106">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0553580%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (6)</a></li>
|
||
<li><a href="/gtr/tests?term=C0553580%5bDISCUI%5d&filter=method%3A2%5F29" target="_blank">Detection of homozygosity (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0553580%5bDISCUI%5d&filter=method%3A3%5F23" target="_blank">FISH-interphase (2)</a></li>
|
||
<li><a href="/gtr/tests?term=C0553580%5bDISCUI%5d&filter=method%3A3%5F31" target="_blank">Fluorescence in situ hybridization (FISH) (2)</a></li>
|
||
<li><a href="/gtr/tests?term=C0553580%5bDISCUI%5d&filter=method%3A2%5F30" target="_blank">RNA analysis (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0553580%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0553580%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (9)</a></li>
|
||
<li><a href="/gtr/tests?term=C0553580%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (1)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0553580%5bDISCUI%5d" target="_blank">See all (16)</a></total></li>
|
||
</ul></div>
|
||
</div>
|
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<div class="portlet mgSection" id="ID_119">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=612219" target="_blank">OMIM</a></li><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=319" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Ewing%20sarcoma" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
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</div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22ewing%20sarcoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Ewing%20sarcoma%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nccn.org/professionals/physician_gls/pdf/sarcoma.pdf">NCCN, 2024</a><div>NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024</div></li><li><a target="_blank" href="https://www.nccn.org/professionals/physician_gls/pdf/bone.pdf">NCCN, 2024</a><div>NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bone Cancer, 2024</div></li></ul></div>
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<div class="ralinkpop offscreen_noflow">Homo sapiens phosphatase and tensin homolog (PTEN), RefSeqGene on chromosome 10<div class="brieflinkpopdesc">gi|170650628|ref|NG_007466.1|</div></div>
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